Roles > prostaglandin receptor agonist
Page last updated: 2024-08-05 15:45:55
prostaglandin receptor agonist
An agonist that binds to and activates prostaglandin receptors.
ChEBI ID: 66900
Members (7)
| Member | Definition | Class |
|---|
| 17-phenyltrinorprostaglandin e2 | A prostanoid that is 18,19,20-trinor-prostaglandin E2 in which one of the terminal methyl hydrogens has been replaced by a phenyl group. | 17-phenyl-18,19,20-trinor-prostaglandin E2 |
| beraprost | An organic heterotricyclic compound that is (3aS,8bS)-2,3,3a,8b-tetrahydro-1H-benzo[b]cyclopenta[d]furan in which the hydrogens at positions 1R, 2R and 5 are replaced by (3S)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl, hydroxy and 3-carboxypropyl groups, respectively. It is a prostaglandin receptor agonist which is approved to treat pulmonary arterial hypertension in Asia. | beraprost |
| beraprost sodium | The organic sodium salt of beraprost. It is used in the treatment of chronic arterial occlusive disease and primary pulmonary hypertension in Japan. | beraprost sodium |
| cay 10580 | A pyrrolidin-2-one substituted by 6-carboxyhexyl and 3-hydroxyoctyl groups at positions 1 and 2, respectively. It is a potent prostaglandin EP4 receptor agonist (Ki=35 nM). | 2-(3-hydroxyoctyl)-5-oxo-1-pyrrolidineheptanoic acid |
| fluprostenol | An organofluorine compound that is racemic prostaglandin F2alpha in which the pentyl group is replaced by a 3-(trifluoromethyl)phenoxymethyl group. A synthetic analogue of prostaglandin F2alpha, ophthalmic solutions of its isopropyl ester prodrug, travoprost, are used as a topical medication for controlling the progression of open-angle glaucoma and ocular hypertension, by reducing intraocular pressure. The isopropyl ester group of travoprost is hydrolysed to the biologically active free acid by esterases in the cornea. | fluprostenol |
| tafluprost | A prostaglandin Falpha that is prostaglandin F2alpha in which the carboxylic acid function has been converted to the corresponding isopropyl ester and the 3-hydroxy-1-octenyl side-chain is substituted by 3,3-difluoro-4-phenoxybut-1-enyl. Used for treatment of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension. | tafluprost |
| travoprost | The isopropyl ester of prostaglandin F2alpha in which the pentyl group is replaced by a 3-(trifluoromethyl)phenoxymethyl group. A synthetic analogue of prostaglandin F2alpha, ophthalmic solutions of travoprost are used as a topical medication for controlling the progression of open-angle glaucoma and ocular hypertension, by reducing intraocular pressure. It is a pro-drug; the isopropyl ester group is hydrolysed by esterases in the cornea to the biologically active free acid, fluprostenol. | travoprost |
Research
Studies (1,078)
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|
| pre-1990 | 42 (3.90) | 18.7374 |
| 1990's | 137 (12.71) | 18.2507 |
| 2000's | 420 (38.96) | 29.6817 |
| 2010's | 409 (37.94) | 24.3611 |
| 2020's | 70 (6.49) | 2.80 |
Study Types
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|
| Trials | 263 (21.97%) | 5.53% |
| Reviews | 111 (9.27%) | 6.00% |
| Case Studies | 74 (6.18%) | 4.05% |
| Observational | 22 (1.84%) | 0.25% |
| Other | 727 (60.74%) | 84.16% |
Protein Targets (18)
Potency Measurements
Inhibition Measurements
Activation Measurements