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prostaglandin receptor agonist

An agonist that binds to and activates prostaglandin receptors.

ChEBI ID: 66900

Members (7)

MemberDefinitionClass
17-phenyltrinorprostaglandin e2A prostanoid that is 18,19,20-trinor-prostaglandin E2 in which one of the terminal methyl hydrogens has been replaced by a phenyl group.17-phenyl-18,19,20-trinor-prostaglandin E2
beraprostAn organic heterotricyclic compound that is (3aS,8bS)-2,3,3a,8b-tetrahydro-1H-benzo[b]cyclopenta[d]furan in which the hydrogens at positions 1R, 2R and 5 are replaced by (3S)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl, hydroxy and 3-carboxypropyl groups, respectively. It is a prostaglandin receptor agonist which is approved to treat pulmonary arterial hypertension in Asia.beraprost
beraprost sodiumThe organic sodium salt of beraprost. It is used in the treatment of chronic arterial occlusive disease and primary pulmonary hypertension in Japan.beraprost sodium
cay 10580A pyrrolidin-2-one substituted by 6-carboxyhexyl and 3-hydroxyoctyl groups at positions 1 and 2, respectively. It is a potent prostaglandin EP4 receptor agonist (Ki=35 nM).2-(3-hydroxyoctyl)-5-oxo-1-pyrrolidineheptanoic acid
fluprostenolAn organofluorine compound that is racemic prostaglandin F2alpha in which the pentyl group is replaced by a 3-(trifluoromethyl)phenoxymethyl group. A synthetic analogue of prostaglandin F2alpha, ophthalmic solutions of its isopropyl ester prodrug, travoprost, are used as a topical medication for controlling the progression of open-angle glaucoma and ocular hypertension, by reducing intraocular pressure. The isopropyl ester group of travoprost is hydrolysed to the biologically active free acid by esterases in the cornea.fluprostenol
tafluprostA prostaglandin Falpha that is prostaglandin F2alpha in which the carboxylic acid function has been converted to the corresponding isopropyl ester and the 3-hydroxy-1-octenyl side-chain is substituted by 3,3-difluoro-4-phenoxybut-1-enyl. Used for treatment of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension.tafluprost
travoprostThe isopropyl ester of prostaglandin F2alpha in which the pentyl group is replaced by a 3-(trifluoromethyl)phenoxymethyl group. A synthetic analogue of prostaglandin F2alpha, ophthalmic solutions of travoprost are used as a topical medication for controlling the progression of open-angle glaucoma and ocular hypertension, by reducing intraocular pressure. It is a pro-drug; the isopropyl ester group is hydrolysed by esterases in the cornea to the biologically active free acid, fluprostenol.travoprost

Research

Studies (1,078)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-199042 (3.90)18.7374
1990's137 (12.71)18.2507
2000's420 (38.96)29.6817
2010's409 (37.94)24.3611
2020's70 (6.49)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials263 (21.97%)5.53%
Reviews111 (9.27%)6.00%
Case Studies74 (6.18%)4.05%
Observational22 (1.84%)0.25%
Other727 (60.74%)84.16%

Protein Targets (18)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
AR proteinHomo sapiens (human)Potency12.208034
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency0.044711
estrogen nuclear receptor alphaHomo sapiens (human)Potency13.908769
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency4.199222
regulator of G-protein signaling 4Homo sapiens (human)Potency0.188911
Spike glycoproteinSevere acute respiratory syndrome-related coronavirusPotency39.810711

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
ATP-binding cassette sub-family C member 3Homo sapiens (human)IC50133.000011
Bile salt export pumpHomo sapiens (human)IC5043.900011
Canalicular multispecific organic anion transporter 1Homo sapiens (human)IC50133.000011
Multidrug resistance-associated protein 4Homo sapiens (human)IC5074.000011
Prostacyclin receptorHomo sapiens (human)Ki13.000011
Prostaglandin D2 receptorHomo sapiens (human)Ki13.000011
Prostaglandin E2 receptor EP1 subtypeHomo sapiens (human)Ki13.000011
Prostaglandin E2 receptor EP2 subtypeHomo sapiens (human)Ki3.000011
Prostaglandin E2 receptor EP3 subtypeHomo sapiens (human)Ki2.000011
Prostaglandin E2 receptor EP4 subtypeHomo sapiens (human)Ki0.035011
Prostaglandin F2-alpha receptorHomo sapiens (human)Ki13.000011
Thromboxane A2 receptor Homo sapiens (human)Ki13.000011

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Prostacyclin receptorHomo sapiens (human)EC5010.000011
Prostaglandin E2 receptor EP3 subtypeHomo sapiens (human)EC503.400011
Prostaglandin F2-alpha receptorHomo sapiens (human)EC500.003611