ascorbic-acid and Fluoride-Poisoning

Topics: Amino Acids; Ascorbic Acid; Biotransformation; Dietary Proteins; Drug Antagonism; Fluoride Poisoning; Folic Acid; Humans; Nicotinic Acids; Nutritional Physiological Phenomena; Pharmaceutical Preparations; Sodium; Trace Elements; Vitamin A; Vitamin D; Vitamin E; Vitamin K; Vitamins

Large populations consume fluoride-contaminated water, especially in developing countries. The toxic effects of fluorosis take three forms: clinical, skeletal and dental. Research thus far indicates that the manifestations of fluorosis are irreversible. However, it has been observed that the ingestion of calcium, vitamin C or vitamin D, individually, is effective in protection from fluoride toxicity to a certain extent. Therefore, a double blind control trial was conducted to examine the effect of a combination of calcium, vitamin D3 and ascorbic acid supplementation in fluorosis-affected children. In the present study, 25 children were selected from an area consuming water containing 4.5 p.p.m. of fluoride, All the children were in the age group 6-12 years and weighed 18-30 kg. They were graded for clinical, radiological and dental fluorosis and relevant biochemical parameters. Grade I skeletal fluorosis and all grades of the manifestation of dental and clinical fluorosis were observed. The children were given ascorbic acid, calcium and vitamin D3 well below the toxic dosages in a double blind manner using lactose as a placebo. Follow up revealed a significant improvement in dental, clinical and skeletal fluorosis and relevant biochemical parameters in these children. Thus, the study indicated that fluorosis can be reversed, at least in children, by a therapeutic regimen that is fairly cheap, simple and easily available and without any side effects.

Topics: Ascorbic Acid; Bone Diseases; Calcium; Child; Cholecalciferol; Double-Blind Method; Drug Monitoring; Drug Therapy, Combination; Fluoride Poisoning; Fluorosis, Dental; Humans; Radiography; Severity of Illness Index

Three hundred and sixteen patients diagnosed as skeletal fluorosis roentgenologically and having no other diseases were divided randomly into 2 groups, matchable in sex distribution, age, functional state and X-ray findings. In the treated group every patient took 200mg vitamin C twice a day, while in the control group placebo tablets. The duration of treatment was 3 months. The therapeutic effect was evaluated by measuring the joint angle and power of gripping and studying the X-ray film and electromyogram. 38 kinds of biochemical parameters were measured simultaneously with a MCA-3 autobiochemical analyser. The results were as follows, (1) The total effective rate in the treated group was 12.84%, chi 2 = 0.556, P > 0.05, so there is no obvious effect in treating skeletal fluorosis with vitamin C. (2) The electromyogram in the treated group showed a recovering rate of 20.00%, chi 2 = 5.9, P > 0.01. It is further shown that there is no effect in treating skeletal fluorosis with vitamin C. (3) 38 kinds of biochemical parameters measured simultaneously and the X-ray findings also showed that vitamin C is not effective. Thus the validity of using vitamin C as the drug of first choice to treat skeletal fluorosis is to be queried.

Topics: Adult; Ascorbic Acid; Bone Diseases; Female; Fluoride Poisoning; Humans; Male; Middle Aged

The effect of daily administration of 2 g of vitamin C on urinary excretion of fluoride in patients suffering from endemic fluorosis was studied. Urinary fluoride excretion was found to be constant over a period of 4 weeks in each patient. The results suggested that vitamin C does not influence the rate of resorption of fluorotic bone in man.

Topics: Adult; Ascorbic Acid; Bone Resorption; Dose-Response Relationship, Drug; Fluoride Poisoning; Fluorides; Humans; India; Male; Middle Aged

Fluoride toxicity occurs due to high concentrations of fluoride in water sources or anthropogenic causes. The aim of the present study was to investigate the effects of an Ayurvedic drug--Pankajakasthuri (PK)--in relation to fluoride-induced toxicity in mammalian lungs. The results indicated that sodium fluoride increased lipid peroxidation and decreased enzymatic and non-enzymatic antioxidants in a concentration-dependent manner in lungs. The antioxidant potential of the lungs was suppressed maximally at 10 ppm fluoride concentration and PK at all three dose levels (i.e., 100, 200 and 300 µl) decreased fluoride induced lipid peroxidation (p < 0.05) and increased the levels of total ascorbic acid, superoxide dismutase, catalase, reduced glutathione, glutathione peroxidase and FRAP values significantly (p < 0.05) in a dose-dependent manner. When PK was examined for its effects on angiotensin-converting enzyme (ACE) activity, in fluoride-induced toxicity, the ACE activity was found to increase (p < 0.0001) in lung homogenates with all three doses. This study indicates that PK, an Ayurvedic drug, improves mammalian lung function by increasing antioxidant potential and ACE activity under the conditions of fluoride toxicity.

Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antioxidants; Ascorbic Acid; Enzyme Activation; Fluoride Poisoning; Glutathione; Goats; Lipid Peroxidation; Lung; Male; Medicine, Ayurvedic; Oxidation-Reduction; Oxidoreductases; Peptidyl-Dipeptidase A; Phytotherapy; Plant Extracts; Plant Preparations; Sodium Fluoride

Topics: Animals; Ascorbic Acid; Calcium; Child; Child, Preschool; Feces; Fluoride Poisoning; Fluorides; Humans; Male; Phosphorus; Rabbits; Rats; Tissue Distribution

Topics: Alkaline Phosphatase; Animals; Ascorbic Acid; Body Weight; Bone and Bones; Bone Development; Calcinosis; Calcium; Calcium, Dietary; Dietary Proteins; Disease Models, Animal; Fluoride Poisoning; Fluorides; Haplorhini; Macaca; Phosphorus; Radiography; Statistics as Topic

Topics: Animals; Ascorbic Acid; Body Weight; Bone and Bones; Calcium; Calcium Isotopes; Calcium, Dietary; Dietary Proteins; Disease Models, Animal; Fluoride Poisoning; Haplorhini; Phosphorus

Topics: Ascorbic Acid; Fluoride Poisoning; Fluorides; Fluorine; Fluorosis, Dental; Vitamins