Fasciculation

Involuntary contraction of the muscle fibers innervated by a motor unit. Fasciculations may be visualized as a muscle twitch or dimpling under the skin, but usually do not generate sufficient force to move a limb. They may represent a benign condition or occur as a manifestation of MOTOR NEURON DISEASE or PERIPHERAL NERVOUS SYSTEM DISEASES. (Adams et al., Principles of Neurology, 6th ed, p1294)

Synonym
Fasciculation, Tongue
Fasciculation, Skeletal Muscle
Fasciculation, Muscular
Fasciculation, Benign
Fasciculation

Excerpt	Reference
"In summary, fasciculations are a frequent ultrasonographic sign in neuromuscular diseases."	( Finkenstaedt, M; Kunkel, M; Reimers, CD; Scheel, AK; Toepfer, M, 1997)
"Fasciculations are a common side effect of the use of succinylcholine for tracheal intubation."	( Carter, PJ; True, CA, 2003)
"Fasciculations are symptoms present in a broad spectrum of conditions, ranging from normal manifestations to motor neuron diseases."	( Carazzo, C; Crusius, CU; Crusius, MU; Crusius, PS; Forcelini, CM; Goellner, E; Mallmann, AB; Posenato, N; Ragnini, J; Rotta, FT; Rovani, JS; Seibert, CA; Wayhs, SY, 2007)
"Fasciculations are a marker for the diagnosis of amyotrophic lateral sclerosis (ALS) and reflect increased lower motor neuron (LMN) excitability."	( de Carvalho, M; Swash, M; Turkman, A, 2019)
"Fasciculations are most commonly seen in the biceps brachii muscle in amyotrophic lateral sclerosis (ALS)."	( Abraham, A; Avidan, R; Bril, V; Drory, VE; Fainmesser, Y, 2021)

Excerpt	Reference
"Diazepam pretreatment prevented muscle fasciculations, increases in serum potassium (K+) and creatinine phosphokinase (CPK) levels, increased heart rate and arterial pressure, and postoperative myalgia associated with SCh administration."	( Fahmy, NR; Lappas, DG; Malek, NS, 1979)
"Every pretreatment prevented fasciculations better than did saline (P less than 0."	( Erkola, O, 1990)
"The occurrence of fasciculations following administration of agents is a well-known pharmacologic phenomenon."	( Baker, T; Stanec, A, 1987)
"Muscle fasciculations and pain following the administration of suxamethonium were assessed in a group of patients who performed a series of stretch exercises approximately 1 h before operation."	( Magee, DA; Robinson, RJ, 1987)
"Total fasciculation score was not significantly reduced by the dantrolene pretreatment."	( Laurence, AS, 1985)
"The mean fasciculation index in all pretreatment groups was significantly smaller than in the control group."	( Lindgren, L; Saarnivaara, L, 1983)
"The incidence of fasciculations was less in the atracurium pretreatment group (group B) than in the group treated with normal saline (group A)."	( Hochhalter, CM, 1996)
"Muscle fasciculations were observed in 19 of the 20 patients in the control group and in 3 of the 20 patients in the rocuronium group, the best of the pretreatments in that aspect."	( Carrier, J; Claprood, Y; Martin, R; Pirlet, M; Tétrault, JP, 1998)
"The incidence and severity of fasciculations and serum concentrations of potassium before anesthesia and 3, 5, and 20 minutes after succinylcholine administration were recorded."	( Burguillos-López, S; Doménech-Asensi, P; Falcón-Araña, LF; Hernández-Palazón, J; Noguera-Velasco, J; Nuño de la Rosa-Carrillo, V, 2004)
"The incidence and degree of fasciculation after succinylcholine administration were recorded."	( Chu, W; Gottlieb, A; Gupta, S; Mendoza, ML; Saager, L; Sessler, DI; Turan, A; You, J, 2011)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	87 (35.22)	23.3326
1990's	87 (35.22)	12.5806
2000's	37 (14.98)	18.1394
2010's	27 (10.93)	28.8240
2020's	9 (3.64)	9.53

Drug	Relationship Strength	Studies	Trials
gamma-aminobutyric acid	low	4	0
beta-alanine	low	1	0
carbamates	low	1	0
chlorine	low	1	0
diacetyl	low	1	0
nitrous oxide	medium	3	1
parathion	low	1	0
huperzine a	low	1	0
4-aminopyridine	low	1	0
phenytoin	low	4	0
tacrine	low	1	0
acetazolamide	low	4	0
aspirin	medium	1	1
azathioprine	low	1	0
betaxolol	low	1	0
bupivacaine	low	1	0
buspirone	low	1	0
caffeine	low	1	0
verapamil	low	2	0
carbamazepine	low	15	0
carteolol	low	1	0
celiprolol	low	1	0
5,7-dimethoxycoumarin	low	1	0
dantrolene	medium	5	2
diazepam	medium	12	3
diazinon	low	1	0
dichlorvos	low	1	0
valproic acid	low	2	0
donepezil	low	2	0
edrophonium	low	4	0
fentanyl	medium	4	3
flunitrazepam	low	1	0
gabapentin	low	3	0
glyburide	low	1	0
haloperidol	low	2	0
halothane	low	4	0
lidocaine	medium	6	5
isoflurane	medium	3	2
ketamine	low	1	0
lorazepam	low	1	0
malathion	low	1	0
methyl parathion	low	1	0
midazolam	medium	1	1
apnea	medium	5	2
neostigmine	low	5	0
nifedipine	low	1	0
nipecotic acid	low	1	0
nitrendipine	low	1	0
oxazepam	low	1	0
procainamide	low	2	0
propofol	medium	4	2
propranolol	low	2	0
succinylcholine	medium	119	55
tetraisopropylpyrophosphamide	low	1	0
tolazoline	low	1	0
penicillamine	low	1	0
prednisone	low	1	0
isoflurophate	low	3	0
lysine	medium	1	1
physostigmine	low	2	0
tubocurarine	medium	24	9
tyrosine	low	2	0
gallamine triethiodide	medium	3	1
tryptophan	low	1	0
methylprednisolone	low	3	0
3,3'-iminodipropionitrile	low	1	0
obidoxime chloride	low	1	0
paraoxon	low	3	0
galantamine	low	1	0
hydantoins	medium	2	1
kainic acid	low	1	0
malondialdehyde	low	2	0
d-alpha tocopherol	low	1	0
mercury	low	1	0
gold	low	1	0
magnesium sulfate	medium	8	6
phenyl acetate	low	2	0
oxcarbazepine	low	1	0
vecuronium bromide	medium	11	6
propiconazole	low	1	0
atracurium	medium	16	12
alfentanil	medium	2	1
fomesafen	low	5	0
remifentanil	medium	3	2
atorvastatin	low	1	0
cisatracurium	medium	3	3
rivastigmine	low	1	0
acetylsalicylic acid lysinate	medium	1	1
2-(2-cresyl)-4h-1-3-2-benzodioxaphosphorin-2-oxide	low	1	0
epibatidine	low	1	0
u 78517f	low	1	0
atropine	low	7	0
glucosamine	low	1	0
inositol 3-phosphate	low	1	0
pancuronium	medium	8	2
rocuronium	medium	18	13
enkephalin, leucine	low	1	0
phenyl-n-tert-butylnitrone	low	1	0
sesquiterpenes	low	1	0
flunarizine	low	1	0
thiopental	medium	7	2
phosphamidon	low	1	0
quinine	low	2	0
myelin basic protein	low	1	0
dinoprost	low	1	0
mivacurium	medium	2	2
toxiferine	medium	2	2
tak 147	low	1	0
pitavastatin	low	1	0
bergamottin	low	1	0
pregabalin	medium	3	1
carbocyanines	low	1	0
tetrodotoxin	low	1	0
diacetylmonoxime	low	1	0
g(m1) ganglioside	low	1	0
phytosterols	low	1	0
jaw	low	2	0
sodium oxybate	low	1	0
sodium ethylxanthate	low	1	0
piperidines	medium	4	2
ascorbic acid	low	1	0
warfarin	low	1	0
transforming growth factor beta	low	1	0
ephrin-a5	low	1	0
neopterin	low	1	0
clozapine	low	2	0
pralidoxime	low	1	0
eye	low	3	0
preproenkephalin	low	1	0

Protein Targets (982)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	14	0	0	14
Genome polyprotein	0	0	1	1
USP1 protein, partial	14	0	0	14
AR protein	39	0	0	39
thyroid stimulating hormone receptor	22	0	0	22
glucocorticoid receptor [Homo sapiens]	35	0	0	35
retinoic acid nuclear receptor alpha variant 1	29	0	0	29
estrogen nuclear receptor alpha	46	0	0	46
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	23	0	0	23
Histone H2A.x	9	0	0	9
chromobox protein homolog 1	17	0	0	17
transcriptional regulator ERG isoform 3	4	0	0	4
geminin	25	0	0	25
Polyphenol oxidase 2	0	2	0	3
Cellular tumor antigen p53	24	0	0	24
Thiopurine S-methyltransferase	0	1	0	1
Succinate-semialdehyde dehydrogenase, mitochondrial	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	2
Cytochrome P450 1B1	0	3	0	3
Dihydropteroate synthase	0	0	1	1
Chain A, Cruzipain	5	0	0	5
thioredoxin reductase	25	0	0	25
RAR-related orphan receptor gamma	22	0	0	22
Microtubule-associated protein tau	14	0	0	14
aldehyde dehydrogenase 1 family, member A1	25	0	0	25
estrogen receptor 2 (ER beta)	11	0	0	11
cytochrome P450 family 3 subfamily A polypeptide 4	22	0	0	22
cytochrome P450 2D6	16	0	0	16
glucocerebrosidase	6	0	0	6
IDH1	11	0	0	11
euchromatic histone-lysine N-methyltransferase 2	40	0	0	40
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	9	0	0	9
cytochrome P450 2D6 isoform 1	10	0	0	10
thyroid hormone receptor beta isoform 2	26	0	0	26
mitogen-activated protein kinase 1	9	0	0	9
peripheral myelin protein 22	19	0	0	19
survival motor neuron protein isoform d	9	0	0	9
lethal factor (plasmid)	9	0	0	9
lamin isoform A-delta10	34	0	0	34
Potassium channel subfamily K member 2	0	3	6	9
Rap guanine nucleotide exchange factor 3	3	0	0	3
Potassium voltage-gated channel subfamily A member 3	0	1	1	2
Acetylcholinesterase	0	9	0	9
Pteridine reductase 1	0	1	0	1
Potassium voltage-gated channel subfamily A member 1	0	2	0	2
Potassium voltage-gated channel subfamily H member 2	0	20	0	20
ATP-dependent phosphofructokinase	16	0	0	16
Chain A, HADH2 protein	12	0	0	12
Chain B, HADH2 protein	12	0	0	12
Chain A, 2-oxoglutarate Oxygenase	9	0	0	9
Chain A, Ferritin light chain	10	0	0	10
acid sphingomyelinase	1	0	0	1
ATAD5 protein, partial	12	0	0	12
GLI family zinc finger 3	34	0	0	34
nuclear receptor subfamily 1, group I, member 3	31	0	0	31
progesterone receptor	23	0	0	23
peroxisome proliferator-activated receptor delta	12	0	0	12
peroxisome proliferator activated receptor gamma	23	0	0	23
alpha-galactosidase	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	5	0	0	5
lethal(3)malignant brain tumor-like protein 1 isoform I	2	0	0	2
cytochrome P450 3A4 isoform 1	16	0	0	16
histone acetyltransferase KAT2A isoform 1	8	0	0	8
Gamma-aminobutyric acid receptor subunit pi	16	13	4	33
Gamma-aminobutyric acid receptor subunit beta-1	16	13	4	33
Gamma-aminobutyric acid receptor subunit delta	16	13	4	33
Gamma-aminobutyric acid receptor subunit gamma-2	16	13	5	34
Gamma-aminobutyric acid receptor subunit alpha-5	16	13	4	33
Gamma-aminobutyric acid receptor subunit alpha-3	16	13	4	33
Gamma-aminobutyric acid receptor subunit gamma-1	16	13	4	33
Gamma-aminobutyric acid receptor subunit alpha-2	16	13	4	33
Genome polyprotein	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	16	13	4	33
Gamma-aminobutyric acid receptor subunit gamma-3	16	13	4	33
Gamma-aminobutyric acid receptor subunit alpha-6	16	13	4	33
Gamma-aminobutyric acid receptor subunit alpha-1	16	14	5	35
Gamma-aminobutyric acid receptor subunit beta-3	16	13	4	33
Gamma-aminobutyric acid receptor subunit beta-2	16	13	5	34
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	2	0	2
GABA theta subunit	16	13	4	33
Gamma-aminobutyric acid receptor subunit epsilon	16	13	4	33
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	9	0	0	9
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Beta-lactamase	6	0	0	6
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Class Iii Chitinase Chia1	0	1	0	1
Chain A, Carbonic anhydrase 13	0	1	0	1
Chain A, Carbonic anhydrase II	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase	0	1	0	1
Chain B, Carbonic anhydrase	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	2	0	2
GALC protein	2	0	0	2
retinoid X nuclear receptor alpha	21	0	0	21
estrogen-related nuclear receptor alpha	39	0	0	39
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	2	0	2
arylsulfatase A	17	0	0	17
Carbonic anhydrase	0	2	0	2
Bloom syndrome protein isoform 1	18	0	0	18
thyroid hormone receptor beta isoform a	15	0	0	15
nuclear factor erythroid 2-related factor 2 isoform 1	28	0	0	28
muscleblind-like protein 1 isoform 1	4	0	0	4
ATP-binding cassette sub-family C member 3	0	28	0	28
Multidrug resistance-associated protein 4	0	28	0	28
Carbonic anhydrase	0	2	0	2
Solute carrier family 22 member 6	0	3	0	3
Carbonic anhydrase 12	0	3	1	9
Prolyl endopeptidase	0	2	0	2
Carbonic anhydrase-related protein 11	0	1	0	3
Bile salt export pump	0	42	0	42
Glycogen phosphorylase, muscle form	0	2	0	2
Renin	0	3	0	3
Carbonic anhydrase 1	0	10	1	19
Carbonic anhydrase 2	0	10	2	19
Carbonic anhydrase 2	0	2	0	2
Cytochrome P450 1A2	0	5	0	5
Carbonic anhydrase 3	0	3	1	8
Cathepsin B	0	1	0	1
Cytochrome P450 3A4	0	16	0	18
Steryl-sulfatase	0	1	0	1
5-hydroxytryptamine receptor 2C	0	7	0	7
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	2
Cytochrome P450 2C8	0	4	0	4
Cytochrome P450 2D6	0	7	0	8
Cytochrome P450 2A6	0	2	0	2
Cytochrome P450 2C9	0	12	0	13
5-hydroxytryptamine receptor 2A	0	11	0	11
Androgen receptor	0	3	0	3
Translocator protein	0	3	1	5
Cannabinoid receptor 1	0	1	0	1
Arachidonate 5-lipoxygenase-activating protein	0	2	0	2
Cytochrome P450 2B6	0	2	1	3
Carbonic anhydrase 4	0	4	1	9
Carbonic anhydrase 6	0	3	1	8
Carbonic anhydrase 5A, mitochondrial	0	2	0	2
Adenosine receptor A1	0	6	0	8
Serum paraoxonase/arylesterase 1	0	1	0	1
Dipeptidyl peptidase 4	0	0	0	1
Endochitinase	0	1	0	1
Adenosine receptor A2a	0	6	0	9
5-hydroxytryptamine receptor 2B	0	7	1	8
Sodium-dependent serotonin transporter	0	5	0	5
Delta-type opioid receptor	0	11	1	13
Cytochrome P450 2C19	0	5	0	6
Delta-type opioid receptor	0	6	0	6
Mu-type opioid receptor	0	10	1	11
Carbonic anhydrase 5A, mitochondrial	0	3	2	10
Carbonic anhydrase	0	3	0	5
Kappa-type opioid receptor	0	8	0	8
Carbonic anhydrase 7	0	3	1	8
Carbonic anhydrase	0	1	0	1
D(1A) dopamine receptor	2	2	0	4
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Carbonic anhydrase	0	2	0	4
D(2) dopamine receptor	0	10	0	10
Cholinesterase	0	12	1	14
Carbonic anhydrase	0	2	0	2
Mu-type opioid receptor	0	7	0	7
Fatty-acid amide hydrolase 1	0	3	0	3
Beta-carbonic anhydrase 1	0	3	0	3
Carbonic anhydrase 2	0	3	0	3
Glutamate receptor ionotropic, NMDA 2B	0	8	1	11
Squalene synthase	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	3	0	3
Carbonic anhydrase 9	0	3	1	9
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase, alpha family	0	2	0	2
Carbonic anhydrase	0	2	0	4
Carbonic anhydrase 3	0	1	0	1
Carbonic anhydrase	0	2	0	5
Carbonic anhydrase	0	2	0	5
Carbonic anhydrase	0	2	0	2
Sigma intracellular receptor 2	0	2	0	2
Delta carbonic anhydrase	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	8	0	8
Renin	0	1	0	1
Carbonic anhydrase	0	2	0	4
Endochitinase A1	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Carbonic anhydrase 13	0	3	1	5
Canalicular multispecific organic anion transporter 1	0	25	0	25
Carbonic anhydrase 4	0	4	0	4
Carbonic anhydrase 15	0	3	0	6
Acidic mammalian chitinase	0	1	0	1
Carbonic anhydrase 13	0	4	0	8
Carbonic anhydrase 7	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 14	0	3	1	9
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 2, isoform A	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	3	1	9
ATP-dependent translocase ABCB1	0	16	1	29
TDP1 protein	29	0	0	29
D(1A) dopamine receptor	11	0	0	11
neuropeptide S receptor isoform A	4	0	0	4
Chain A, Hyaluronidase, phage associated	0	1	0	1
acetylcholinesterase	19	0	0	19
thioredoxin glutathione reductase	5	0	0	5
vitamin D (1,25- dihydroxyvitamin D3) receptor	19	0	0	19
nuclear factor erythroid 2-related factor 2 isoform 2	4	0	0	4
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	1	0	1
Urease	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	1	0	1
Alpha-2B adrenergic receptor	0	6	2	9
Spike glycoprotein	10	0	0	10
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
Chain A, Phospholipase A2 isoform 3	0	0	1	1
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
interleukin 8	4	0	0	4
GLS protein	17	0	0	17
hypothetical protein, conserved	2	0	0	2
EWS/FLI fusion protein	11	0	0	11
Rac1 protein	0	0	1	1
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
DNA polymerase iota isoform a (long)	9	0	0	9
DNA polymerase kappa isoform 1	4	0	0	4
muscarinic acetylcholine receptor M1	19	0	0	19
Prostaglandin-H2 D-isomerase	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Prostaglandin G/H synthase 2	0	2	0	2
Epidermal growth factor receptor	0	1	0	1
Fatty acid-binding protein, liver	0	3	0	3
Integrin beta-3	3	1	0	4
Myeloperoxidase	0	2	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Integrin alpha-IIb	3	1	0	4
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	4	0	4
Substance-P receptor	0	2	0	2
Prostaglandin G/H synthase 2	0	4	0	4
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Nuclear receptor ROR-gamma	7	0	0	7
Ras-related protein Rab-2A	0	0	1	1
Prostaglandin G/H synthase 2	0	1	0	1
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	13	1	14
Sigma non-opioid intracellular receptor 1	0	4	1	5
SMAD family member 2	7	0	0	7
SMAD family member 3	7	0	0	7
caspase 7, apoptosis-related cysteine protease	4	0	0	4
pregnane X nuclear receptor	34	0	0	34
caspase-3	4	0	0	4
Caspase-7	2	0	0	2
vitamin D3 receptor isoform VDRA	10	0	0	10
caspase-3	2	0	0	2
Voltage-dependent calcium channel gamma-2 subunit	12	0	0	12
Solute carrier organic anion transporter family member 2B1	0	0	0	2
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	2	0	2
Insulin receptor	0	1	0	1
Glutamate receptor 2	12	2	1	15
Dipeptidyl peptidase 4	0	1	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	2	0	2
Histone deacetylase 1	0	4	0	4
Histone deacetylase 2	0	4	0	4
Solute carrier organic anion transporter family member 1B3	0	0	0	1
Histone deacetylase 6	0	4	0	4
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	6	1	7
Solute carrier organic anion transporter family member 1B1	0	4	0	6
NPYLR7B	0	0	1	1
Amine oxidase [flavin-containing] A	0	3	1	4
Small conductance calcium-activated potassium channel protein 3	0	3	1	4
cystic fibrosis transmembrane conductance regulator	0	1	0	1
DNA polymerase beta	5	0	0	5
short transient receptor potential channel 6 isoform 1	0	0	2	2
Solute carrier family 22 member 1	0	11	0	13
5-hydroxytryptamine receptor 4	0	16	0	16
Muscarinic acetylcholine receptor M2	0	9	3	16
Muscarinic acetylcholine receptor M4	0	7	2	12
Muscarinic acetylcholine receptor M1	0	7	1	10
Muscarinic acetylcholine receptor M3	0	7	1	10
Muscarinic acetylcholine receptor M4	0	7	1	10
Muscarinic acetylcholine receptor M5	0	7	1	10
Muscarinic acetylcholine receptor M5	0	8	1	12
Muscarinic acetylcholine receptor M2	0	8	1	12
Muscarinic acetylcholine receptor M1	0	10	3	17
Muscarinic acetylcholine receptor M1	0	0	0	1
Muscarinic acetylcholine receptor M3	0	8	3	14
Alpha-1D adrenergic receptor	0	10	1	12
5-hydroxytryptamine receptor 2C	0	17	2	19
Muscarinic acetylcholine receptor M4	0	1	0	1
Histamine H2 receptor	9	0	0	11
5-hydroxytryptamine receptor 7	0	5	0	5
Reverse transcriptase/RNaseH	0	0	0	1
Muscarinic acetylcholine receptor	0	1	1	3
phosphopantetheinyl transferase	9	0	0	9
Fumarate hydratase	4	0	0	4
farnesoid X nuclear receptor	17	0	0	17
G	13	0	0	13
polyprotein	4	0	0	4
P53	1	0	0	1
aryl hydrocarbon receptor	14	0	0	14
thyroid stimulating hormone receptor	9	0	0	9
activating transcription factor 6	11	0	0	11
v-jun sarcoma virus 17 oncogene homolog (avian)	10	0	0	10
peripheral myelin protein 22 isoform 1	10	0	0	10
hemoglobin subunit beta	1	0	0	1
cellular tumor antigen p53 isoform a	4	0	0	4
heat shock protein beta-1	11	0	0	11
M-phase phosphoprotein 8	8	0	0	8
Bile salt export pump	0	14	0	14
Interferon beta	14	0	0	14
HLA class I histocompatibility antigen, B alpha chain	13	0	0	13
Inositol hexakisphosphate kinase 1	13	0	0	13
ATPase family AAA domain-containing protein 5	10	0	0	10
Ataxin-2	13	0	0	13
Protein-arginine deiminase type-4	0	1	0	1
cytochrome P450 2C9, partial	13	0	0	13
Chain A, JmjC domain-containing histone demethylation protein 3A	5	0	0	5
cytochrome P450 2C19 precursor	6	0	0	6
cytochrome P450 2C9 precursor	7	0	0	7
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	4	0	0	4
Cytochrome P450 2B1	0	1	0	1
Cytochrome P450 2B4	0	1	0	1
Cytochrome P450 2E1	0	2	0	2
Cytochrome P450 3A5	0	1	0	1
Beta-secretase 1	0	4	0	4
regulator of G-protein signaling 4	13	0	0	13
Sodium- and chloride-dependent GABA transporter 1	0	4	0	4
Sodium- and chloride-dependent GABA transporter 2	0	3	0	3
Sodium- and chloride-dependent GABA transporter 3	0	3	0	3
Sodium- and chloride-dependent betaine transporter	0	2	0	2
Glutamate receptor ionotropic, NMDA 1	1	6	1	10
Sodium- and chloride-dependent GABA transporter 3	0	3	0	3
Glutamate receptor ionotropic, NMDA 2A	0	6	1	9
Glutamate receptor ionotropic, NMDA 2C	0	6	1	9
Glutamate receptor ionotropic, NMDA 2D	0	6	1	9
Proton-coupled amino acid transporter 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 3B	0	6	1	9
Sodium- and chloride-dependent GABA transporter 2	0	3	0	3
Glutamate receptor ionotropic, NMDA 3A	0	6	1	9
Beta-1 adrenergic receptor	0	2	2	5
hexokinase-4 isoform 1	2	0	0	2
glucokinase regulatory protein	2	0	0	2
Beta-1 adrenergic receptor	0	4	2	6
Beta-1 adrenergic receptor	0	5	2	8
5-hydroxytryptamine receptor 1A	0	18	3	22
Beta-2 adrenergic receptor	0	0	1	1
Beta-2 adrenergic receptor	0	1	2	5
Potassium channel subfamily K member 3	0	2	0	2
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 9	0	1	0	1
hypoxia-inducible factor 1 alpha subunit	10	0	0	10
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	9	0	0	9
potassium voltage-gated channel subfamily H member 2 isoform d	12	0	0	12
Solute carrier family 22 member 2	0	6	0	8
5-hydroxytryptamine receptor 1A	0	7	2	9
Beta-2 adrenergic receptor	0	7	0	8
Angiotensin-converting enzyme	0	1	0	1
D(2) dopamine receptor	0	10	2	17
Alpha-1B adrenergic receptor	0	13	4	17
D	0	5	0	5
D(3) dopamine receptor	0	6	0	6
Alpha-2B adrenergic receptor	0	5	3	8
D(2) dopamine receptor	0	5	0	5
Alpha-2C adrenergic receptor	0	5	3	8
Alpha-2A adrenergic receptor	0	5	3	8
Alpha-1D adrenergic receptor	0	9	4	13
D(1B) dopamine receptor	0	5	0	5
Beta-3 adrenergic receptor	0	5	0	5
5-hydroxytryptamine receptor 2A	0	12	1	15
5-hydroxytryptamine receptor 1B	0	11	0	11
5-hydroxytryptamine receptor 1D	0	4	0	4
D(4) dopamine receptor	0	5	0	5
5-hydroxytryptamine receptor 1F	0	4	0	4
5-hydroxytryptamine receptor 7	0	4	1	5
D(3) dopamine receptor	0	11	1	16
5-hydroxytryptamine receptor 2B	0	14	2	16
Alpha-1A adrenergic receptor	0	13	4	17
5-hydroxytryptamine receptor 3A	0	2	0	2
5-hydroxytryptamine receptor 6	0	6	1	8
Alpha-2A adrenergic receptor	0	1	0	1
D	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
Multidrug and toxin extrusion protein 2	0	4	0	4
D	0	4	0	4
Multidrug and toxin extrusion protein 1	0	5	0	5
Lysosomal alpha-glucosidase	0	1	0	1
Chain A, Glycogen Phosphorylase	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Chitinase	0	1	0	1
atrial natriuretic peptide receptor 1 precursor	4	0	0	4
nuclear receptor ROR-gamma isoform 1	11	0	0	11
Cholinesterase	0	19	0	19
Glycogen phosphorylase, liver form	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
Replicase polyprotein 1ab	0	1	0	1
Adenosine receptor A3	0	7	1	8
Replicase polyprotein 1ab	0	1	0	1
Amine oxidase [flavin-containing] A	0	3	0	3
Acetylcholinesterase	0	24	5	31
Amine oxidase [flavin-containing] B	0	4	0	4
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Adenosine receptor A3	0	1	0	1
Adenosine receptor A2a	0	4	2	7
Adenosine receptor A2b	0	1	0	2
Adenosine receptor A2b	0	2	0	3
Adenosine receptor A1	0	3	1	6
Vasopressin V2 receptor	0	0	0	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Adenosine receptor A2a	0	1	0	1
Adenosine receptor A1	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	0	1
DNA-dependent protein kinase catalytic subunit	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Adenylate cyclase type 1	0	0	0	1
Chitotriosidase-1	0	1	0	1
Serine-protein kinase ATM	0	1	0	1
Serine/threonine-protein kinase ATR	0	1	0	1
Adenosine receptor A2b	0	1	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	1	2	3
Endochitinase B1	0	1	0	1
Phosphodiesterase	0	1	0	1
Guanine deaminase	0	1	0	1
Vpr	1	0	0	1
Albumin	0	0	5	5
Major prion protein	0	0	2	2
Sodium channel protein type 1 subunit alpha	0	3	0	3
Sodium channel protein type 2 subunit alpha	0	6	0	6
Sodium channel protein type 3 subunit alpha	0	3	0	3
UDP-glucuronosyltransferase 2B7	0	3	0	6
Sodium channel protein type 4 subunit alpha	0	7	0	9
Cytochrome P450 2J2	0	8	0	9
Sodium channel protein type 9 subunit alpha	0	8	0	8
Frizzled-8	0	0	1	1
P2X purinoceptor 4	0	2	0	2
5-hydroxytryptamine receptor 3E	0	1	0	1
Luciferase	9	0	0	9
NFKB1 protein, partial	4	0	0	4
bromodomain adjacent to zinc finger domain 2B	6	0	0	6
Adenylate cyclase type 1	0	2	0	2
atrial natriuretic peptide receptor 2 precursor	2	0	0	2
transient receptor potential cation channel subfamily V member 1	3	0	0	3
Polyunsaturated fatty acid lipoxygenase ALOX15B	5	0	0	5
Voltage-dependent L-type calcium channel subunit alpha-1F	0	11	0	11
5-hydroxytryptamine receptor 3A	0	1	0	1
5-hydroxytryptamine receptor 3B	0	1	0	1
Aldo-keto reductase family 1 member B1	0	11	0	11
Alpha-2A adrenergic receptor	0	9	2	12
Calmodulin-1	0	1	0	1
Angiotensin-converting enzyme	0	5	0	5
Alpha-2C adrenergic receptor	0	7	2	10
Endothelin receptor type B	0	1	0	1
D(1A) dopamine receptor	0	7	1	10
D(4) dopamine receptor	0	5	1	10
D(1B) dopamine receptor	0	3	0	5
Adenylate cyclase type 3	0	2	0	2
UDP-glucuronosyltransferase 1A4	0	1	0	3
Sodium-dependent noradrenaline transporter	0	12	0	12
Sodium-dependent dopamine transporter	0	4	0	4
5-hydroxytryptamine receptor 3A	0	2	0	2
Endothelin receptor type B	0	1	0	1
Histamine H2 receptor	0	6	0	6
Adenylate cyclase type 2	0	2	0	2
Adenylate cyclase type 4	0	2	0	2
Histamine H1 receptor	0	1	0	1
Histamine H1 receptor	0	4	0	4
Sodium-dependent serotonin transporter	0	12	0	12
5-hydroxytryptamine receptor 7	0	2	0	2
5-hydroxytryptamine receptor 2C	0	2	0	2
Alpha-1A adrenergic receptor	0	3	2	6
5-hydroxytryptamine receptor 2A	0	2	0	2
Histamine H1 receptor	0	7	2	11
Alpha-1B adrenergic receptor	0	2	1	4
5-hydroxytryptamine receptor 3A	0	1	0	1
Adenylate cyclase type 8	0	2	0	2
5-hydroxytryptamine receptor 5A	0	1	0	1
D(2) dopamine receptor	0	2	0	2
D(3) dopamine receptor	0	2	0	2
Gastrin/cholecystokinin type B receptor	0	2	0	2
D(2) dopamine receptor	0	1	0	1
Calmodulin	0	0	1	1
Inositol monophosphatase 1	6	0	0	6
Voltage-dependent L-type calcium channel subunit alpha-1D	0	11	0	11
Sodium-dependent dopamine transporter	0	3	0	3
5-hydroxytryptamine receptor 2B	0	2	0	2
Adenylate cyclase type 6	0	2	0	2
Adenylate cyclase type 5	0	2	0	2
5-hydroxytryptamine receptor 4	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1S	0	11	0	11
Voltage-dependent L-type calcium channel subunit alpha-1C	0	14	0	15
Transporter	0	2	0	2
Cholecystokinin receptor type A	0	2	0	2
5-hydroxytryptamine receptor 1A	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	4	0	4
5-hydroxytryptamine receptor 3D	0	1	0	1
Adenylyl cyclase 7	0	2	0	2
5-hydroxytryptamine receptor 3C	0	1	0	1
Histamine H4 receptor	0	1	1	2
5-hydroxytryptamine receptor 3B	0	1	0	1
Transporter	0	2	0	2
Histamine H3 receptor	0	2	0	2
importin subunit beta-1 isoform 1	3	0	0	3
snurportin-1	3	0	0	3
GTP-binding nuclear protein Ran isoform 1	2	0	0	2
Glutathione S-transferase P	0	1	0	1
Alpha-tocopherol transfer protein	0	0	1	1
endonuclease IV	5	0	0	5
Thrombopoietin	3	0	0	3
Cocaine esterase	0	3	0	3
Coagulation factor XII	0	2	0	2
Liver carboxylesterase 1	0	1	0	1
Liver carboxylesterase 1	0	5	0	5
Gamma-aminobutyric acid	0	2	1	3
glp-1 receptor, partial	5	0	0	5
Gamma-aminobutyric acid receptor subunit pi	0	5	0	5
Gamma-aminobutyric acid receptor subunit delta	0	5	0	5
Alpha-1-acid glycoprotein 1	0	0	0	1
Albumin	0	1	6	8
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	0	4
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	4
Neuronal acetylcholine receptor subunit alpha-4	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	4
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	0	4
Neuronal acetylcholine receptor subunit beta-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	7	6	13
Gamma-aminobutyric acid receptor subunit alpha-6	0	2	1	3
Gamma-aminobutyric acid receptor subunit beta-1	0	5	2	7
Gamma-aminobutyric acid receptor subunit gamma-2	0	7	4	11
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	4
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	0	4
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	1	3
Gamma-aminobutyric acid receptor subunit delta	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	1	3
Gamma-aminobutyric acid receptor subunit gamma-3	0	2	1	3
Gamma-aminobutyric acid receptor subunit beta-3	0	7	3	10
Translocator protein	0	1	0	1
Translocator protein	0	4	0	4
Cholecystokinin receptor type A	0	2	0	2
Gastrin/cholecystokinin type B receptor	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-5	0	6	5	11
Gamma-aminobutyric acid receptor subunit alpha-3	0	6	3	9
Gamma-aminobutyric acid receptor subunit alpha-2	0	6	3	9
Gamma-aminobutyric acid receptor subunit beta-2	0	6	4	10
Gamma-aminobutyric acid receptor subunit alpha-4	0	5	2	7
Gamma-aminobutyric acid receptor subunit beta-1	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	1	3
Gamma-aminobutyric acid receptor subunit beta-3	0	2	1	3
Gamma-aminobutyric acid receptor subunit epsilon	0	5	0	5
Gamma-aminobutyric acid receptor subunit alpha-6	0	6	2	8
Gamma-aminobutyric acid receptor subunit alpha-5	0	2	1	3
Gamma-aminobutyric acid receptor subunit gamma-1	0	5	0	5
Gamma-aminobutyric acid receptor subunit pi	0	2	1	3
Sphingosine-1-phosphate lyase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	5	0	5
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	1	3
Gamma-aminobutyric acid receptor subunit theta	0	2	1	3
Gamma-aminobutyric acid receptor subunit gamma-1	0	2	1	3
Gamma-aminobutyric acid receptor subunit theta	0	5	0	5
isocitrate dehydrogenase 1, partial	1	0	0	1
Rap guanine nucleotide exchange factor 4	2	0	0	2
15-lipoxygenase, partial	4	0	0	4
pregnane X receptor	6	0	0	6
nuclear factor NF-kappa-B p105 subunit isoform 1	3	0	0	3
Acetylcholinesterase	0	1	0	1
Thromboxane A2 receptor	0	1	1	2
Prostaglandin E2 receptor EP1 subtype	0	1	1	2
Prostaglandin E2 receptor EP4 subtype	0	1	0	1
Prostaglandin F2-alpha receptor	0	2	0	2
Prostaglandin F2-alpha receptor	0	2	1	3
Prostaglandin E2 receptor EP3 subtype	0	1	1	2
Prostaglandin E2 receptor EP2 subtype	0	1	0	1
Prostaglandin F2-alpha receptor	0	0	1	1
Prostacyclin receptor	0	1	0	1
Solute carrier organic anion transporter family member 2A1	0	1	0	2
Prostaglandin D2 receptor	0	1	0	1
Solute carrier family 22 member 6	0	0	0	1
Solute carrier family 22 member 7	0	1	0	2
Solute carrier family 22 member 8	0	0	0	1
Solute carrier organic anion transporter family member 2A1	0	1	0	2
Solute carrier organic anion transporter family member 2A1	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	1	0	1
Solute carrier family 22 member 11	0	0	0	1
Solute carrier family 22 member 7	0	0	0	1
Acetylcholinesterase	0	13	2	16
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Acetylcholinesterase	0	8	1	9
Amyloid-beta precursor protein	0	2	0	2
Amine oxidase [flavin-containing] B	0	3	0	3
Amine oxidase [flavin-containing] A	0	2	0	2
Acetylcholinesterase	0	11	1	12
Acetylcholinesterase	0	8	0	8
Choline O-acetyltransferase	0	2	0	2
Glycogen synthase kinase-3 beta	0	3	0	3
Cholinesterase	0	4	0	4
Acetylcholine receptor subunit epsilon	0	3	0	3
Acyl-CoA:cholesterol acyltransferase	0	3	0	3
Carboxylic ester hydrolase	0	4	0	5
Carboxylic ester hydrolase	0	8	0	8
dopamine D1 receptor	2	0	0	2
POU domain, class 2, transcription factor 1	0	0	0	1
Opioid receptor, delta 1b	0	1	0	1
Opioid receptor homologue	0	1	0	1
Proenkephalin-B	0	0	1	1
Kappa-type opioid receptor	0	1	0	1
Kappa-type opioid receptor	0	3	0	3
Mu-type opioid receptor	0	9	4	13
Delta-type opioid receptor	0	4	2	6
Kappa-type opioid receptor	0	4	2	6
Mu-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	1	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Voltage-dependent T-type calcium channel subunit alpha-1G	0	1	1	2
Voltage-dependent T-type calcium channel subunit alpha-1H	0	1	1	2
Cannabinoid receptor 1	0	3	0	3
Voltage-dependent L-type calcium channel subunit beta-1	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Voltage-dependent N-type calcium channel subunit alpha-1B	0	2	0	2
Voltage-dependent N-type calcium channel subunit alpha-1B	0	1	0	1
Potassium channel subfamily K member 2	0	2	0	2
Voltage-dependent T-type calcium channel subunit alpha-1I	0	1	1	2
Prostaglandin D2 receptor 2	0	1	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Chain A, ACETYLCHOLINESTERASE	0	1	0	1
Chain A, Acetylcholinesterase	0	1	0	1
Vascular endothelial growth factor receptor 1	0	1	0	1
Vascular endothelial growth factor receptor 3	0	1	0	1
Vascular endothelial growth factor receptor 2	0	1	0	1
Prolyl endopeptidase	0	1	0	1
Gamma-aminobutyric acid receptor subunit rho-3	0	0	1	1
Hsf1 protein	0	0	1	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	5	0	0	5
Histone deacetylase 3	0	3	0	3
Gamma-aminobutyric acid type B receptor subunit 2	0	0	1	1
Gamma-aminobutyric acid type B receptor subunit 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	3	0	3
Gamma-aminobutyric acid receptor subunit rho-1	0	0	2	2
Gamma-aminobutyric acid receptor subunit rho-2	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	2	0	2
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	4	0	4
Sodium- and chloride-dependent GABA transporter 3	0	3	0	3
Sodium- and chloride-dependent betaine transporter	0	3	0	3
Sodium- and chloride-dependent betaine transporter	0	2	0	2
Histone deacetylase 4	0	3	0	3
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
TAR DNA-binding protein 43	4	0	0	4
Sterol O-acyltransferase 1	0	0	1	1
Histone deacetylase 7	0	3	0	3
Polyamine deacetylase HDAC10	0	3	0	3
Histone deacetylase 11	0	3	0	3
Histone deacetylase 8	0	3	0	3
Platelet glycoprotein VI	0	0	1	1
Gamma-aminobutyric acid type B receptor subunit 1	0	0	1	1
Histone deacetylase 9	0	3	0	3
Histone deacetylase 5	0	3	0	3
Gamma-aminobutyric acid type B receptor subunit 1	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	7	0	0	7
nonstructural protein 1	9	0	0	9
Parkin	3	0	0	3
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	3	0	0	3
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	3	0	0	3
ATP-binding cassette sub-family C member 9	0	1	0	1
Chymotrypsinogen A	0	2	0	2
Beta-lactamase	0	1	0	1
ATP synthase subunit beta, mitochondrial	0	1	0	1
ATP synthase subunit delta, mitochondrial	0	1	0	1
ATP synthase subunit gamma, mitochondrial	0	1	0	1
ATP synthase subunit epsilon, mitochondrial	0	1	0	1
Cystic fibrosis transmembrane conductance regulator	0	1	0	1
Cholesteryl ester transfer protein	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	1	0	1
Malate dehydrogenase, cytoplasmic	0	1	0	1
Solute carrier family 15 member 1	0	1	0	1
Guanine nucleotide-binding protein G	2	0	0	2
ATP-binding cassette sub-family C member 8	0	1	0	1
ATP-sensitive inward rectifier potassium channel 11	0	1	0	1
Solute carrier family 15 member 2	0	1	0	1
NACHT, LRR and PYD domains-containing protein 3	0	1	0	1
NACHT, LRR and PYD domains-containing protein 3	0	1	0	1
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
serine/threonine-protein kinase mTOR isoform 1	4	0	0	4
Transient receptor potential cation channel subfamily V member 1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	6	0	6
UDP-glucuronosyltransferase 1A9	0	1	0	4
Vitamin D-binding protein	0	1	0	1
HLA class I histocompatibility antigen, A alpha chain	0	0	1	1
Integrin beta-1	0	1	0	1
Integrin alpha-4	0	1	0	1
Carbonyl reductase [NADPH] 1	0	0	0	1
C-8 sterol isomerase	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	4	0	4
5-hydroxytryptamine receptor 2A	0	1	0	1
AP-2 complex subunit sigma	0	1	0	1
N-acetyltransferase Eis	0	2	0	2
Sodium channel protein type 7 subunit alpha	0	3	0	3
Sodium channel protein type 5 subunit alpha	0	7	0	7
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	1	0	1
Calcitonin gene-related peptide type 1 receptor	0	1	0	1
Genome polyprotein	0	2	0	2
Sigma intracellular receptor 2	0	1	0	1
Zinc finger protein 664	0	1	0	1
Vesicular acetylcholine transporter	0	1	0	1
Protease	0	3	0	3
Sodium channel protein type 2 subunit alpha	0	4	0	4
Transient receptor potential cation channel subfamily V member 4	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	5	0	5
Sodium channel protein type 11 subunit alpha	0	3	0	3
Sodium channel protein type 8 subunit alpha	0	3	0	3
Transient receptor potential cation channel subfamily V member 2	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	3	0	3
Glycogen synthase kinase-3 alpha	0	1	0	1
Protein cereblon	0	2	0	2
Neuronal acetylcholine receptor subunit beta-2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Lysosomal protective protein	0	1	0	1
Fatty acid synthase	0	1	0	1
Liver carboxylesterase	0	1	0	1
Chain A, Glutamate receptor 2	0	0	1	1
Chain A, Glutamate receptor 2	0	0	1	1
Chain C, Glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 6	0	0	1	1
Glutamate receptor 1	0	2	1	3
Glutamate receptor 3	0	2	1	3
Glutamate receptor 4	0	2	1	3
Glutamate receptor ionotropic, kainate 1	0	2	1	3
Glutamate receptor ionotropic, kainate 1	0	2	1	3
Metabotropic glutamate receptor 5	0	0	1	1
Glutamate receptor ionotropic, kainate 2	0	2	2	4
Glutamate receptor 1	0	1	1	2
Glutamate receptor 2	0	1	1	2
Glutamate receptor 3	0	0	1	1
Glutamate receptor ionotropic, kainate 3	0	2	0	2
Glutamate receptor 4	0	1	0	1
Glutamate receptor ionotropic, kainate 4	0	2	0	2
Glutamate receptor ionotropic, kainate 2	0	2	1	3
Glutamate receptor ionotropic, kainate 3	0	2	0	2
Glutamate receptor ionotropic, kainate 4	0	1	0	1
Glutamate receptor ionotropic, kainate 5	0	2	0	2
Glutamate receptor ionotropic, kainate 5	0	2	0	2
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	3	0	3
Glutamate receptor ionotropic, NMDA 2A	0	3	0	3
Glutamate receptor ionotropic, NMDA 2B	0	3	0	3
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
flap endonuclease 1	4	0	0	4
Potassium voltage-gated channel subfamily A member 5	0	2	0	2
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Glutathione reductase, mitochondrial	0	4	0	4
Cationic amino acid transporter 3	0	1	0	1
Carboxylic ester hydrolase	0	1	0	1
67.9K protein	2	0	0	2
PPM1D protein	2	0	0	2
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
Glucocorticoid receptor	0	4	1	5
Glycine receptor subunit alpha-1	0	4	0	4
Glycine receptor subunit beta	0	4	0	4
Glycine receptor subunit alpha-2	0	4	0	4
Glycine receptor subunit alpha-3	0	4	0	4
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
ATP-dependent translocase ABCB1	0	2	0	2
UDP-glucuronosyltransferase 1-6	0	1	0	2
ATP-dependent translocase ABCB1	0	2	0	3
UDP-glucuronosyltransferase 1A1	0	1	0	1
UDP-glucuronosyltransferase 2B10	0	1	0	1
Smad3	2	0	0	2
beta-2 adrenergic receptor	1	0	0	1
tumor necrosis factor	1	0	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
perilipin-5	0	1	0	1
perilipin-1	0	1	0	1
serine/threonine-protein kinase PLK1	1	0	0	1
eyes absent homolog 2 isoform a	1	0	0	1
urokinase-type plasminogen activator precursor	2	0	0	2
plasminogen precursor	2	0	0	2
urokinase plasminogen activator surface receptor precursor	2	0	0	2
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	2	0	2
Phospholipase A2, membrane associated	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	4	0	4
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	1	0	1
Thromboxane-A synthase	0	2	0	2
Platelet-activating factor receptor	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
Indoleamine 2,3-dioxygenase 1	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	1	0	1
C-C chemokine receptor type 2	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
C-terminal-binding protein 1	1	0	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	2	0	2
Leukotriene B4 receptor 1	0	0	0	1
Myosin light chain kinase, smooth muscle	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	2	2
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Leukotriene B4 receptor 2	0	0	0	1
G-protein coupled receptor 55	0	1	0	1
Platelet-activating factor receptor	0	1	0	1
polyadenylate-binding protein 1	0	1	0	1
bcl-2-related protein A1	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
Muscarinic acetylcholine receptor DM1	0	1	0	1
Xaa-Pro dipeptidase	0	0	0	1
Cystathionine gamma-lyase	0	1	0	1
Succinyl-diaminopimelate desuccinylase	0	1	0	1
Retinoid isomerohydrolase	0	1	0	1
Retinoid isomerohydrolase	0	1	0	1
Retinoid isomerohydrolase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Acetylcholinesterase	0	1	0	1
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	2	0	3
Voltage-dependent calcium channel subunit alpha-2/delta-2	0	2	0	2
Solute carrier family 22 member 1	0	2	0	2
Sterol O-acyltransferase 1	0	1	0	1
Solute carrier family 22 member 2	0	2	0	2
Solute carrier family 22 member 3	0	1	0	1
DNA (cytosine-5)-methyltransferase 1	0	1	0	1
Sterol O-acyltransferase 1	0	1	0	1
Solute carrier family 22 member 1	0	4	0	5
Solute carrier family 22 member 2	0	4	0	4
Solute carrier family 22 member 4	0	1	0	1
DNA (cytosine-5)-methyltransferase 3-like	0	1	0	1
DNA (cytosine-5)-methyltransferase 3A	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
heat shock protein 90, putative	0	0	0	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Fatty-acid amide hydrolase 1	0	1	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
Beta-2 adrenergic receptor	0	2	1	3
Beta-3 adrenergic receptor	0	2	1	3
Endothelin-1 receptor	0	1	1	2
5-hydroxytryptamine receptor 1B	0	3	1	4
Neuromedin-K receptor	0	0	1	1
Type-1 angiotensin II receptor	0	1	1	2
Cholecystokinin receptor type A	0	1	1	2
Beta-1 adrenergic receptor	0	1	0	1
Vasopressin V1a receptor	0	1	1	2
Beta-2 adrenergic receptor	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	1
Nuclear receptor subfamily 2 group E member 1	0	0	2	2
Solute carrier organic anion transporter family member 1A4	0	1	0	1
Histidine-rich protein PFHRP-II	0	1	0	1
Cytochrome P450 2D1	0	1	0	1
Cytochrome P450 2D26	0	1	0	1
Cytochrome P450 2D3	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	1
Cytochrome P450 2D4	0	1	0	1
Acyl-CoA desaturase 1	0	2	0	2
Acetylcholine receptor subunit epsilon	0	1	0	1
Cholinesterase	0	1	0	1
Tyrosine-protein kinase SYK	0	1	0	1
Free fatty acid receptor 3	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, ACETYLCHOLINESTERASE	0	1	0	1
Chain A, liver Carboxylesterase I	0	1	0	1
Chain A, Histamine N-methyltransferase	0	1	0	1
Chain A, Histamine N-methyltransferase	0	1	0	1
Chain A, Histamine N-methyltransferase	0	1	0	1
Chain A, Histamine N-methyltransferase	0	1	0	1
Glycogen synthase kinase-3 beta	0	1	0	1
[Tau protein] kinase	0	1	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Voltage-dependent L-type calcium channel subunit beta-4	0	1	0	1
Voltage-dependent P/Q-type calcium channel subunit alpha-1A	0	1	0	1
Voltage-dependent calcium channel gamma-3 subunit	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
Muscarinic acetylcholine receptor M2	0	0	2	2
Fatty acid-binding protein, liver	0	0	1	1
Neuronal acetylcholine receptor subunit beta-4	0	1	0	1
Trypanothione reductase	0	1	0	1
Cannabinoid receptor 2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	0	1
Histamine N-methyltransferase	0	0	0	1
Gastrotropin	0	0	1	1
Voltage-dependent L-type calcium channel subunit beta-3	0	1	0	1
Voltage-dependent calcium channel gamma-7 subunit	0	1	0	1
Cyclin-dependent-like kinase 5	0	1	0	1
Histamine N-methyltransferase	0	1	0	1
Voltage-dependent L-type calcium channel subunit beta-1	0	1	0	1
Voltage-dependent calcium channel gamma-1 subunit	0	1	0	1
Voltage-dependent L-type calcium channel subunit beta-2	0	1	0	1
Cyclin-dependent kinase 5 activator 1	0	1	0	1
Voltage-dependent R-type calcium channel subunit alpha-1E	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-4	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-3	0	1	0	1
Voltage-dependent calcium channel gamma-8 subunit	0	1	0	1
Voltage-dependent calcium channel gamma-6 subunit	0	1	0	1
Voltage-dependent calcium channel gamma-4 subunit	0	1	0	1
Voltage-dependent calcium channel gamma-5 subunit	0	1	0	1
Voltage-dependent calcium channel gamma-2 subunit	0	1	0	1
5-hydroxytryptamine receptor 1D	0	1	0	1
Trace amine-associated receptor 1	0	1	0	1
Chain A, Carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Chain A, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain K, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain B, tryptophanyl-tRNA synthetase	0	0	1	1
Chain C, Tryptophanyl-tRNA synthetase II	0	0	1	1
Dihydrofolate reductase	0	2	0	2
Plasma kallikrein	0	0	0	2
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Stromelysin-1	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	2
Tryptophan 2,3-dioxygenase	0	1	0	2
Large neutral amino acids transporter small subunit 1	0	2	0	2
SLC16A10 protein	0	0	0	2
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Carbonic anhydrase-like protein, putative	0	0	0	2
Tryprostatin B synthase	0	0	0	1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Monocarboxylate transporter 10	0	0	0	2
Phospholipase A-2-activating protein	0	1	0	1
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
Tubulin--tyrosine ligase	0	1	0	1
Taste receptor type 2 member 14	0	0	0	1
Tissue factor	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member B7	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
lysosomal alpha-glucosidase preproprotein	1	0	0	1
huntingtin isoform 2	1	0	0	1
Glycoprotein	0	1	0	1
Catechol O-methyltransferase	0	1	0	1
Multidrug resistance-associated protein 1	0	2	1	4
Chloroquine resistance transporter	0	1	0	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(5)

Research Excerpts

Overview

Treatment

Research

Studies (247)

Protein Targets (982)

Fasciculation

Synonyms(5)

Research Excerpts

Overview

Treatment

Research

Studies (247)

Drugs Studied (144)

Protein Targets (982)