An agent that inhibits bone resorption and/or favor bone mineralization and bone regeneration. Used to heal bone fractures and to treat bone diseases such as osteopenia and osteoporosis.
| Member | Definition | Class |
|---|
| 1,25-dihydroxyergocalciferol | A hydroxycalciol that is vitamin D2 bearing additional hydroxy substituents at positions 1alpha and 25. | 1alpha,25-dihydroxyvitamin D2 |
| 25-hydroxyvitamin d 2 | A hydroxycalciol that is vitamin D2 in which the hydrogen at position 25 has been replaced by a hydroxy group. | 25-hydroxyvitamin D2 |
| 3-(n,n-dimethylsulfonamido)-4-methyl-nitrobenzene | A C-nitro compound that is benzene substituted by N,N-dimethylaminosulfonyl, methyl and nitro groups at positions 1, 2 and 5, respectively. It is a phosphodiesterase inhibitor selective for the PDE7 subtype (Ki = 180 nM). | BRL-50481 |
| alendronate | A 1,1-bis(phosphonic acid) that is methanebis(phosphonic acid) in which the two methylene hydrogens are replaced by hydroxy and 3-aminopropyl groups. | alendronic acid |
| alendronate sodium | A hydride that is the trihydrate of alendronate sodium | alendronate sodium trihydrate |
| azd2858 | A member of the class of pyrazines that is pyrazine substituted by (pyridin-3-yl)aminocarbonyl, amino, and 4-(4-methylpiperazine-1-sulfonyl)phenyl groups at positions 2, 3 and 6, respectively. It is a potent inhibitor of GSK3alpha and GSK3beta (IC50 values of 0.9 and 4.9 nM, respectively) and increases bone mass (via Wnt activation) in rats. | AZD2858 |
| calcifediol | A hydroxycalciol that is calciol in which the hydrogen at position 25 has been replaced by a hydroxy group. A prehormone resulting from the oxidation of calciol in the liver, it is further hydroxylated in the kidney to give calcitriol, the active form of vitamin D3. | calcidiol |
| calcitriol | A hydroxycalciol that is calcidiol in which the pro-S hydrogen of calcidiol is replaced by a hydroxy group. It is the active form of vitamin D3, produced fom calciol via hydoxylation in the liver to form calcidiol, which is subsequently oxidised in the kidney to give calcitriol. | calcitriol |
| clodronate disodium | The disodium salt of clodronic acid. It inhibits bone resorption and soft tissue calcification, and is used (generally as the tetrahydrate) as an adjunct in the treatment of severe hypercalcaemia associated with malignancy, and in the management of osteolytic lesions and bone pain associated with skeletal metastases. | clodronic acid disodium salt |
| clodronic acid | An organochlorine compound that is methylene chloride in which both hydrogens are replaced by phosphonic acid groups. It inhibits bone resorption and soft tissue calcification, and is used (often as the disodium salt tetrahydrate) as an adjunct in the treatment of severe hypercalcaemia associated with malignancy, and in the management of osteolytic lesions and bone pain associated with skeletal metastases. | clodronic acid |
| diosmetin | A monomethoxyflavone that is the 4'-methyl ether derivative of luteolin. It is a natural product isolated from citrus fruits which exhibits a range of pharmacological activities. | diosmetin |
| estrone | A 17-oxo steroid that is estra-1,3,5(10)-triene substituted by an hydroxy group at position 3 and an oxo group at position 17. | estrone |
| etidronate | A 1,1-bis(phosphonic acid) that is (ethane-1,1-diyl)bis(phosphonic acid) having a hydroxy substituent at the 1-position. It inhibits the formation, growth, and dissolution of hydroxyapatite crystals by chemisorption to calcium phosphate surfaces. | etidronic acid |
| etidronate disodium | An organic sodium salt resulting from the replacement of two protons from etidronic acid (one from from each of the phosphonic acid groups) by sodium ions. | etidronate disodium |
| galgravin | A member of the class of aryltetrahydrofurans carrying two 3,4-dimethoxyphenyl substituents at positions 2 and 5 as well as two methyl groups at positions 3 and 4. | galgravin |
| ginsenoside rh2 | A ginsenoside found in Panax species that is dammarane which is substituted by hydroxy groups at the 3beta, 12beta and 20 pro-S positions, in which the hydroxy group at position 3 has been converted to the corresponding beta-D-glucopyranoside, and in which a double bond has been introduced at the 24-25 position. | (20S)-ginsenoside Rh2 |
| hu 308 | A carbobicyclic compound that is bicyclo[3.1.1]hept-2-ene which is substituted by a hydroxymethyl group at position 2, a 2,6-dimethoxy-4-(2-methyloctan-2-yl)phenyl group at position 4, and two methyl groups at position 6 (the 1S,4S,5S stereoisomer). A highly selective and effective cannabinoid type-2 agonist and the enantiomer of HU-433. | HU-308 |
| icariin | A member of the class of flavonols that is kaempferol which is substituted at position 8 by a 3-methylbut-2-en-1-yl group and in which the hydroxy groups at positions 3, 4', and 7 have been converted to the corresponding 6-deoxy-alpha-L-mannopyranoside, methyl ether, and beta-D-glucopyranoside, respectively. A phoshphodiesterase-5 inhibitor, it is obtained from several species of plants in the genus Epimedium and is thought to be the main active ingredient of the Chinese herbal medicine Herba Epimedii (yinyanghuo). | icariin |
| ipriflavone | A member of the class of isoflavones that is isoflavone in which the hydrogen at position 7 is replaced by an isopropoxy group. A synthetic isoflavone, it was formerly used for the treatment of osteoporosis, although a randomised controlled study failed to show any benefit. It is still used to prevent osteoporosis in post-menopausal women. | ipriflavone |
| lasofoxifene | A member of the class of tetralins that is 5,6,7,8-tetrahydronaphthalen-2-ol in which the hydrogens at positions 5 and 6 are replaced by 4-[2-(pyrrolidin-1-yl)ethoxy]phenyl and phenyl groups, respectively (the 5R,6S-stereoisomer). It is a selective estrogen receptor modulator indicated for the prevention and treatment of osteoporosis in post-menopausal women. | lasofoxifene |
| lespenefril | A glycosyloxyflavone that is kaempferol attached to alpha-L-rhamnopyranosyl residues at positions 3 and 7 respectively via glycosidic linkages. It has been isolated from the aerial parts of Vicia faba and Lotus edulis. | kaempferol 3,7-di-O-alpha-L-rhamnoside |
| ly 117018 | A member of the class of 1-benzothiophenes that is raloxifene in which the piperidin-1-yl group has been replaced by a pyrrolidin-1-yl group. | LY 117018 |
| menaquinone 7 | A menaquinone whose side-chain contains seven isoprene units in an all-trans-configutation. | menaquinone-7 |
| menatetrenone | A menaquinone whose side-chain contains 4 isoprene units in an all-trans-configuration. | menaquinone-4 |
| methylene diphosphonate | A 1,1-bis(phosphonic acid) consisting of methane substituted by two phosphonic acid groups. | medronic acid |
| quercetin 3-o-glucopyranoside | A quercetin O-glucoside that is quercetin with a beta-D-glucosyl residue attached at position 3. Isolated from Lepisorus contortus, it exhibits antineoplastic activityand has been found to decrease the rate of polymerization and sickling of red blood cells | quercetin 3-O-beta-D-glucopyranoside |
| raloxifene | A member of the class of 1-benzothiophenes that is 1-benzothiophene in which the hydrogens at positions 2, 3, and 6 have been replaced by p-hydroxyphenyl, p-[2-(piperidin-1-yl)ethoxy]benzoyl, and hydroxy groups, respectively. | raloxifene |
| raloxifene hydrochloride | A hydrochloride salt resulting from the reaction of equimolar amounts of raloxifene and hydrogen chloride. | raloxifene hydrochloride |
| salmon calcitonin | A 32-membered heterodetic cyclic peptide comprising the sequence Cys-Ser-Asn-Leu-Ser-Thr-Cys-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Gly-Thr-Pro-NH2 cyclised by a disulfide bridge between the two Cys residues at positions 1 and 7. | calcitonin |
| sciadopitysin | A biflavonoid that is a 7, 4', 4'''-trimethyl ether derivative of amentoflavone. | sciadopitysin |
| tamoxifen | | tamoxifen |
| tibolone | Estran-3-one with a double bond between positions 5 and 10, and bearing both an ethynyl group and a hydroxy group at position 17 (R-configuration). A synthetic steroid hormone drug which acts as an agonist at all five type I steroid hormone receptors, it is used in the prevention of postmenopausal osteoporosis and for treatment of endometriosis. | tibolone |
| tocotrienol, delta | A tocotrienol that is chroman-6-ol substituted by methyl groups at positions 2 and 8 and a farnesyl chain at position 2. | delta-tocotrienol |
| toremifene | | toremifene |
| ursodoxicoltaurine | A bile acid taurine conjugate derived from ursoodeoxycholic acid. | tauroursodeoxycholic acid |
| vitamin d 2 | A vitamin D supplement and has been isolated from alfalfa. | vitamin D2 |
| zoledronic acid | An imidazole compound having a 2,2-bis(phosphono)-2-hydroxyethane-1-yl substituent at the 1-position. | zoledronic acid |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 28.2941 | 1 | 3 |
| 67.9K protein | Vaccinia virus | Potency | 8.9125 | 1 | 1 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 22.2288 | 4 | 16 |
| acid sphingomyelinase | Homo sapiens (human) | Potency | 14.1254 | 1 | 1 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 42.7466 | 2 | 8 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 8.0875 | 2 | 6 |
| Alpha-synuclein | Homo sapiens (human) | Potency | 18.3564 | 1 | 1 |
| apical membrane antigen 1, AMA1 | Plasmodium falciparum 3D7 | Potency | 19.5147 | 1 | 2 |
| AR protein | Homo sapiens (human) | Potency | 20.4668 | 11 | 62 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 21.6930 | 2 | 11 |
| arylsulfatase A | Homo sapiens (human) | Potency | 3.1555 | 1 | 2 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 12.7499 | 3 | 5 |
| Ataxin-2 | Homo sapiens (human) | Potency | 37.8142 | 2 | 9 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 17.6661 | 2 | 4 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 36.5348 | 2 | 10 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 18.8230 | 2 | 6 |
| BRCA1 | Homo sapiens (human) | Potency | 0.6310 | 1 | 1 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 55.0109 | 1 | 3 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 56.4631 | 1 | 4 |
| caspase-3 | Cricetulus griseus (Chinese hamster) | Potency | 51.9755 | 1 | 3 |
| caspase-3 | Homo sapiens (human) | Potency | 56.4631 | 1 | 4 |
| Caspase-7 | Cricetulus griseus (Chinese hamster) | Potency | 51.9755 | 1 | 3 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 53.9990 | 3 | 13 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 24.8808 | 2 | 6 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 10.9656 | 1 | 3 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 14.9600 | 2 | 5 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 39.8107 | 1 | 1 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 20.1309 | 2 | 4 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 6.6149 | 1 | 5 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 55.0581 | 1 | 4 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 12.0181 | 2 | 6 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 11.0530 | 1 | 2 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 40.0831 | 1 | 5 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 6.6149 | 1 | 5 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 55.3390 | 2 | 6 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 15.9775 | 1 | 3 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 12.5674 | 1 | 2 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 10.8142 | 1 | 8 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 18.9615 | 1 | 4 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 21.5617 | 1 | 3 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 9.2916 | 2 | 12 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 8.0559 | 2 | 5 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 1.8381 | 1 | 7 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 4.5189 | 2 | 4 |
| D(1A) dopamine receptor | Sus scrofa (pig) | Potency | 18.9850 | 1 | 2 |
| Disintegrin and metalloproteinase domain-containing protein 17 | Homo sapiens (human) | Potency | 5.0119 | 1 | 1 |
| DNA dC->dU-editing enzyme APOBEC-3G isoform 1 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 29.9976 | 1 | 3 |
| DNA polymerase III, partial | Bacillus subtilis | Potency | 29.9349 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 28.0929 | 1 | 5 |
| endonuclease IV | Escherichia coli | Potency | 21.3882 | 1 | 3 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 9.9534 | 12 | 79 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 13.5762 | 3 | 20 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 27.9662 | 9 | 50 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 15.9480 | 1 | 17 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 10.8010 | 4 | 13 |
| eyes absent homolog 2 isoform a | Homo sapiens (human) | Potency | 79.4328 | 1 | 1 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 44.5571 | 5 | 9 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 29.7141 | 1 | 3 |
| G | Vesicular stomatitis virus | Potency | 10.8142 | 1 | 8 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 9.2916 | 1 | 6 |
| GALC protein | Homo sapiens (human) | Potency | 0.6310 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 9.2916 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 9.2916 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 9.2916 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 9.2916 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 9.2916 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 9.2916 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 9.2916 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 9.2916 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 9.2916 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 9.2916 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 9.2916 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 9.2916 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 9.2916 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 9.2916 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 9.2916 | 1 | 6 |
| geminin | Homo sapiens (human) | Potency | 17.1896 | 3 | 10 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 9.0934 | 3 | 24 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| GLS protein | Homo sapiens (human) | Potency | 2.8184 | 1 | 1 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 22.7571 | 1 | 4 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 29.3487 | 5 | 26 |
| glucokinase regulatory protein | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 8.8277 | 1 | 8 |
| GTP-binding nuclear protein Ran isoform 1 | Homo sapiens (human) | Potency | 17.7828 | 1 | 1 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 46.1248 | 2 | 7 |
| hexokinase-4 isoform 1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 10.0535 | 2 | 12 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| histone deacetylase 9 isoform 3 | Homo sapiens (human) | Potency | 2.8650 | 2 | 4 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 46.0876 | 2 | 4 |
| histone-lysine N-methyltransferase 2A isoform 2 precursor | Homo sapiens (human) | Potency | 33.5520 | 1 | 2 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 10.8142 | 1 | 8 |
| huntingtin isoform 2 | Homo sapiens (human) | Potency | 18.5331 | 2 | 2 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 50.4396 | 2 | 8 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 6.3096 | 2 | 2 |
| IDH1 | Homo sapiens (human) | Potency | 24.1130 | 1 | 4 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 37.0084 | 2 | 2 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 10.8142 | 1 | 16 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 3.5481 | 1 | 1 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 22.4748 | 1 | 3 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 22.4748 | 1 | 3 |
| Interferon beta | Homo sapiens (human) | Potency | 18.3287 | 2 | 20 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 8.3969 | 2 | 9 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 13.8834 | 1 | 4 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 2.3434 | 4 | 6 |
| lysosomal alpha-glucosidase preproprotein | Homo sapiens (human) | Potency | 2.4803 | 2 | 2 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 19.9305 | 1 | 4 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 16.8151 | 2 | 11 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 12.8654 | 1 | 4 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 10.5697 | 2 | 3 |
| muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 206.8415 | 1 | 4 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| NFKB1 protein, partial | Homo sapiens (human) | Potency | 7.1941 | 2 | 6 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 19.9740 | 1 | 2 |
| NPC intracellular cholesterol transporter 1 precursor | Homo sapiens (human) | Potency | 19.7811 | 1 | 3 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 30.6292 | 4 | 14 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 8.2718 | 1 | 2 |
| nuclear factor NF-kappa-B p105 subunit isoform 1 | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 43.6227 | 2 | 9 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 17.4825 | 2 | 11 |
| nuclear receptor subfamily 1, group I, member 2 | Rattus norvegicus (Norway rat) | Potency | 8.0826 | 1 | 2 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 36.5010 | 3 | 22 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 64.9162 | 1 | 3 |
| peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 79.4328 | 1 | 1 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 20.0775 | 2 | 7 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 45.3006 | 1 | 3 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 40.9837 | 5 | 13 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 35.0014 | 4 | 9 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 56.6755 | 2 | 7 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 12.5893 | 1 | 1 |
| polyprotein | Zika virus | Potency | 29.7141 | 1 | 3 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 7.5397 | 1 | 3 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 18.6963 | 1 | 4 |
| PPM1D protein | Homo sapiens (human) | Potency | 23.3383 | 1 | 8 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 16.1982 | 3 | 14 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 79.4328 | 1 | 1 |
| progesterone receptor | Homo sapiens (human) | Potency | 33.3127 | 3 | 13 |
| Rap guanine nucleotide exchange factor 3 | Homo sapiens (human) | Potency | 42.4083 | 2 | 3 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 17.9451 | 2 | 23 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 31.1126 | 1 | 3 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 11.0180 | 1 | 2 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 24.7858 | 3 | 27 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 27.1058 | 4 | 15 |
| serine/threonine-protein kinase mTOR isoform 1 | Homo sapiens (human) | Potency | 19.7263 | 4 | 7 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 42.7392 | 3 | 9 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 42.7392 | 3 | 9 |
| Smad3 | Homo sapiens (human) | Potency | 35.4813 | 1 | 2 |
| snurportin-1 | Homo sapiens (human) | Potency | 37.0084 | 2 | 2 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 29.8816 | 1 | 2 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 3.1623 | 1 | 1 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 4.4668 | 1 | 2 |
| TDP1 protein | Homo sapiens (human) | Potency | 21.5884 | 2 | 20 |
| thioredoxin glutathione reductase | Schistosoma mansoni | Potency | 31.8305 | 1 | 4 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 32.1041 | 1 | 4 |
| Thrombopoietin | Homo sapiens (human) | Potency | 15.8489 | 2 | 2 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 14.0633 | 3 | 18 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 49.6990 | 3 | 3 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 55.4650 | 4 | 7 |
| thyrotropin-releasing hormone receptor | Homo sapiens (human) | Potency | 27.3185 | 2 | 4 |
| transcriptional regulator ERG isoform 3 | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| ubiquitin carboxyl-terminal hydrolase 2 isoform a | Homo sapiens (human) | Potency | 5.0119 | 1 | 1 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 12.5893 | 1 | 1 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 12.5893 | 1 | 1 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 44.7731 | 1 | 6 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 37.5452 | 2 | 8 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 25.1288 | 4 | 11 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 46.0310 | 1 | 4 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 8.8277 | 1 | 8 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 10 kDa chaperonin | Escherichia coli | IC50 | 34.5000 | 2 | 2 |
| 10 kDa heat shock protein, mitochondrial | Homo sapiens (human) | IC50 | 45.0000 | 1 | 1 |
| 17-beta-hydroxysteroid dehydrogenase type 1 | Homo sapiens (human) | IC50 | 0.4134 | 5 | 5 |
| 17-beta-hydroxysteroid dehydrogenase type 1 | Homo sapiens (human) | Ki | 4.7515 | 2 | 2 |
| 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase | Homo sapiens (human) | IC50 | 0.0120 | 1 | 1 |
| 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase | Homo sapiens (human) | Ki | 0.0030 | 1 | 2 |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | IC50 | 12.1600 | 1 | 1 |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | Ki | 6.9490 | 1 | 1 |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | IC50 | 12.1600 | 1 | 1 |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | Ki | 6.9490 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | IC50 | 3.1255 | 1 | 2 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | Ki | 0.8930 | 1 | 2 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | IC50 | 5.3563 | 1 | 3 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | Ki | 2.5743 | 2 | 4 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | IC50 | 0.8190 | 1 | 2 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | Ki | 0.4290 | 1 | 2 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | IC50 | 0.8190 | 1 | 2 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | Ki | 0.4290 | 1 | 2 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | IC50 | 2.6790 | 1 | 1 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | Ki | 1.7900 | 2 | 4 |
| 60 kDa chaperonin | Escherichia coli K-12 | IC50 | 250.0000 | 1 | 1 |
| 60 kDa chaperonin | Escherichia coli | IC50 | 34.5000 | 2 | 2 |
| 60 kDa heat shock protein, mitochondrial | Homo sapiens (human) | IC50 | 45.0000 | 1 | 1 |
| 7-dehydrocholesterol reductase | Homo sapiens (human) | IC50 | 0.0120 | 1 | 1 |
| 72 kDa type IV collagenase | Homo sapiens (human) | IC50 | 52.0000 | 3 | 4 |
| Acetylcholinesterase | Homo sapiens (human) | IC50 | 13,725.2000 | 2 | 2 |
| Adenosine receptor A1 | Homo sapiens (human) | IC50 | 23.7670 | 1 | 1 |
| Adenosine receptor A1 | Homo sapiens (human) | Ki | 13.8640 | 1 | 1 |
| Adenosine receptor A2a | Homo sapiens (human) | IC50 | 4.6050 | 1 | 2 |
| Adenosine receptor A2a | Homo sapiens (human) | Ki | 2.5850 | 1 | 2 |
| Adenosine receptor A3 | Homo sapiens (human) | IC50 | 3.7010 | 1 | 1 |
| Adenosine receptor A3 | Homo sapiens (human) | Ki | 2.0920 | 1 | 1 |
| Aldehyde oxidase | Homo sapiens (human) | IC50 | 0.0055 | 2 | 2 |
| Aldehyde oxidase | Homo sapiens (human) | Ki | 0.0009 | 4 | 4 |
| Aldehyde oxidase 1 | Macaca fascicularis (crab-eating macaque) | IC50 | 0.5000 | 1 | 1 |
| Aldehyde oxidase 1 | Mus musculus (house mouse) | IC50 | 0.5000 | 1 | 1 |
| Aldehyde oxidase 1 | Oryctolagus cuniculus (rabbit) | IC50 | 0.0080 | 1 | 1 |
| Aldehyde oxidase 1 | Rattus norvegicus (Norway rat) | IC50 | 1.1000 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Homo sapiens (human) | IC50 | 75.9000 | 2 | 2 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | IC50 | 2.1666 | 2 | 4 |
| Aldo-keto reductase family 1 member B1 | Sus scrofa (pig) | IC50 | 16.0000 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | Ki | 1.4102 | 1 | 3 |
| alkaline phosphatase, germ cell type preproprotein | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| alkaline phosphatase, intestinal | Homo sapiens (human) | IC50 | 7.1050 | 2 | 2 |
| alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein | Homo sapiens (human) | IC50 | 14.0000 | 1 | 1 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 3.7010 | 1 | 1 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 2.0920 | 1 | 1 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 3.7010 | 1 | 1 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 2.0920 | 1 | 1 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | IC50 | 2.9775 | 1 | 2 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | Ki | 1.4635 | 1 | 2 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | IC50 | 1.7995 | 1 | 2 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | Ki | 0.6750 | 1 | 2 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | IC50 | 3.6080 | 1 | 2 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | Ki | 1.6470 | 1 | 2 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | IC50 | 0.7380 | 1 | 1 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | Ki | 0.1070 | 1 | 1 |
| Alpha-synuclein | Homo sapiens (human) | IC50 | 54.0500 | 2 | 2 |
| Amine oxidase [flavin-containing] A | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| Amine oxidase [flavin-containing] B | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| Amyloid-beta precursor protein | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Androgen receptor | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Androgen receptor | Rattus norvegicus (Norway rat) | IC50 | 11.6036 | 2 | 4 |
| Androgen receptor | Rattus norvegicus (Norway rat) | Ki | 7.6428 | 1 | 3 |
| Angiotensin-converting enzyme | Oryctolagus cuniculus (rabbit) | IC50 | 0.9670 | 1 | 1 |
| Angiotensin-converting enzyme | Oryctolagus cuniculus (rabbit) | Ki | 0.7922 | 1 | 1 |
| Arginase | Leishmania amazonensis | IC50 | 2.0000 | 1 | 1 |
| Aromatase | Homo sapiens (human) | Ki | 2.5000 | 1 | 1 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 5 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | IC50 | 19.7250 | 4 | 4 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | Ki | 0.1000 | 1 | 1 |
| Aurora kinase B | Homo sapiens (human) | IC50 | 7.2800 | 1 | 2 |
| B2 bradykinin receptor | Homo sapiens (human) | IC50 | 20.3560 | 1 | 1 |
| B2 bradykinin receptor | Homo sapiens (human) | Ki | 12.0480 | 1 | 1 |
| Beta-1 adrenergic receptor | Homo sapiens (human) | IC50 | 17.2890 | 1 | 1 |
| Beta-1 adrenergic receptor | Homo sapiens (human) | Ki | 9.9840 | 1 | 1 |
| Beta-3 adrenergic receptor | Homo sapiens (human) | IC50 | 7.7030 | 1 | 1 |
| Beta-3 adrenergic receptor | Homo sapiens (human) | Ki | 5.7780 | 1 | 1 |
| Beta-secretase 1 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Bifunctional epoxide hydrolase 2 | Homo sapiens (human) | IC50 | 28.4300 | 1 | 1 |
| Bile acid receptor | Homo sapiens (human) | IC50 | 11.5600 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 236.1000 | 5 | 12 |
| Broad substrate specificity ATP-binding cassette transporter ABCG2 | Homo sapiens (human) | IC50 | 6.5000 | 2 | 2 |
| C-8 sterol isomerase | Saccharomyces cerevisiae S288C | Ki | 0.7830 | 1 | 2 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4B | Homo sapiens (human) | IC50 | 117.2667 | 3 | 3 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4D | Homo sapiens (human) | IC50 | 1.2800 | 1 | 1 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 119.1667 | 2 | 6 |
| Cannabinoid receptor 1 | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 2 | 2 |
| Cannabinoid receptor 2 | Homo sapiens (human) | Ki | 0.0204 | 6 | 6 |
| Carbonic anhydrase 1 | Homo sapiens (human) | IC50 | 10.0000 | 2 | 2 |
| Carbonic anhydrase 1 | Homo sapiens (human) | Ki | 10.0000 | 2 | 2 |
| Carbonic anhydrase 12 | Homo sapiens (human) | IC50 | 0.3160 | 2 | 2 |
| Carbonic anhydrase 12 | Homo sapiens (human) | Ki | 0.1110 | 2 | 2 |
| Carbonic anhydrase 14 | Homo sapiens (human) | IC50 | 0.0920 | 2 | 2 |
| Carbonic anhydrase 2 | Homo sapiens (human) | IC50 | 416.7080 | 2 | 3 |
| Carbonic anhydrase 2 | Homo sapiens (human) | Ki | 418.8737 | 3 | 3 |
| Carbonic anhydrase 4 | Homo sapiens (human) | Ki | 2,670.0378 | 2 | 2 |
| Carbonic anhydrase 5A, mitochondrial | Homo sapiens (human) | Ki | 730.0000 | 1 | 1 |
| Carbonic anhydrase 7 | Homo sapiens (human) | Ki | 0.0038 | 1 | 1 |
| Carbonic anhydrase 9 | Homo sapiens (human) | IC50 | 290.2153 | 2 | 3 |
| Carbonic anhydrase 9 | Homo sapiens (human) | Ki | 860.0000 | 1 | 1 |
| caspase-3 isoform a preproprotein | Homo sapiens (human) | IC50 | 19.7000 | 1 | 1 |
| cGMP-specific 3',5'-cyclic phosphodiesterase | Homo sapiens (human) | IC50 | 5.9000 | 1 | 1 |
| Chain A, CES1 protein | Homo sapiens (human) | Ki | 15.2000 | 1 | 1 |
| Chain A, farnesyl pyrophosphate synthase | Trypanosoma cruzi | IC50 | 147.0000 | 1 | 1 |
| Corticosteroid-binding globulin | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| Cruzipain | Trypanosoma cruzi | IC50 | 87.8000 | 3 | 5 |
| Cyclin-dependent kinase 2 | Homo sapiens (human) | Ki | 0.5400 | 1 | 1 |
| Cytochrome P450 1A1 | Homo sapiens (human) | IC50 | 0.1400 | 1 | 1 |
| Cytochrome P450 1A1 | Homo sapiens (human) | Ki | 0.0890 | 1 | 1 |
| Cytochrome P450 1A2 | Homo sapiens (human) | IC50 | 2.4370 | 1 | 1 |
| Cytochrome P450 1B1 | Homo sapiens (human) | IC50 | 25.0145 | 2 | 2 |
| Cytochrome P450 1B1 | Homo sapiens (human) | Ki | 0.0160 | 2 | 2 |
| Cytochrome P450 2B6 | Homo sapiens (human) | Ki | 0.9000 | 1 | 1 |
| Cytochrome P450 2C19 | Homo sapiens (human) | IC50 | 3.0000 | 1 | 1 |
| Cytochrome P450 2C19 | Homo sapiens (human) | Ki | 0.0001 | 1 | 1 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 1.0046 | 2 | 2 |
| Cytochrome P450 2D6 | Homo sapiens (human) | Ki | 0.0001 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 0.0093 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | Ki | 3.3667 | 3 | 3 |
| D(1A) dopamine receptor | Homo sapiens (human) | IC50 | 6.1830 | 1 | 2 |
| D(1A) dopamine receptor | Homo sapiens (human) | Ki | 3.0915 | 1 | 2 |
| D(2) dopamine receptor | Homo sapiens (human) | IC50 | 7.5295 | 1 | 2 |
| D(2) dopamine receptor | Homo sapiens (human) | Ki | 2.5095 | 1 | 2 |
| D(3) dopamine receptor | Homo sapiens (human) | IC50 | 1.3185 | 1 | 2 |
| D(3) dopamine receptor | Homo sapiens (human) | Ki | 0.4475 | 1 | 2 |
| D(4) dopamine receptor | Homo sapiens (human) | IC50 | 11.1610 | 1 | 1 |
| D(4) dopamine receptor | Homo sapiens (human) | Ki | 3.9130 | 1 | 1 |
| Delta-type opioid receptor | Homo sapiens (human) | IC50 | 9.9915 | 1 | 2 |
| Delta-type opioid receptor | Homo sapiens (human) | Ki | 3.5220 | 1 | 2 |
| Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 | Homo sapiens (human) | IC50 | 10.3000 | 1 | 1 |
| Emopamil-binding protein-like | Homo sapiens (human) | Ki | 0.0028 | 1 | 1 |
| Epidermal growth factor receptor | Homo sapiens (human) | IC50 | 3.5530 | 1 | 1 |
| Estrogen receptor | Homo sapiens (human) | IC50 | 0.4484 | 96 | 116 |
| Estrogen receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0064 | 3 | 5 |
| Estrogen receptor | Homo sapiens (human) | Ki | 0.0230 | 13 | 16 |
| Estrogen receptor | Rattus norvegicus (Norway rat) | Ki | 0.0004 | 1 | 1 |
| Estrogen receptor beta | Homo sapiens (human) | IC50 | 0.5098 | 68 | 87 |
| Estrogen receptor beta | Rattus norvegicus (Norway rat) | IC50 | 0.0995 | 3 | 5 |
| Estrogen receptor beta | Homo sapiens (human) | Ki | 0.0213 | 10 | 12 |
| Estrogen receptor beta | Rattus norvegicus (Norway rat) | Ki | 0.0027 | 1 | 1 |
| Estrogen-related receptor gamma | Homo sapiens (human) | IC50 | 0.0622 | 1 | 1 |
| Farnesyl diphosphate synthase | Escherichia coli K-12 | IC50 | 1.1000 | 1 | 1 |
| Farnesyl pyrophosphate synthase | Homo sapiens (human) | IC50 | 3.3360 | 27 | 33 |
| Farnesyl pyrophosphate synthase | Homo sapiens (human) | Ki | 0.1229 | 3 | 5 |
| Farnesyl pyrophosphate synthase | Leishmania donovani | IC50 | 0.1100 | 1 | 1 |
| Farnesyl pyrophosphate synthase | Leishmania donovani | Ki | 0.0530 | 1 | 2 |
| Farnesyl pyrophosphate synthase | Leishmania major | Ki | 0.0505 | 1 | 2 |
| Fe(3+)-Zn(2+) purple acid phosphatase | Phaseolus vulgaris | Ki | 140.0000 | 1 | 1 |
| G1/S-specific cyclin-E1 | Homo sapiens (human) | Ki | 0.5400 | 1 | 1 |
| G1/S-specific cyclin-E2 | Homo sapiens (human) | Ki | 0.5400 | 1 | 1 |
| Gastric inhibitory polypeptide receptor | Homo sapiens (human) | IC50 | 0.0004 | 1 | 1 |
| Geranylgeranyl pyrophosphate synthase | Homo sapiens (human) | IC50 | 167.2734 | 8 | 15 |
| Geranylgeranyl pyrophosphate synthase | Saccharomyces cerevisiae S288C | IC50 | 14.6491 | 3 | 7 |
| Geranylgeranyl pyrophosphate synthase | Homo sapiens (human) | Ki | 2.7000 | 1 | 1 |
| Geranylgeranyl pyrophosphate synthase | Saccharomyces cerevisiae S288C | Ki | 0.2600 | 1 | 1 |
| Ghrelin O-acyltransferase | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| Glycogen synthase kinase-3 beta | Homo sapiens (human) | IC50 | 0.0050 | 1 | 1 |
| Glycogen synthase kinase-3 beta | Mus musculus (house mouse) | IC50 | 0.0760 | 1 | 1 |
| Glycogen synthase kinase-3 beta | Homo sapiens (human) | Ki | 0.0049 | 1 | 1 |
| H | Trypanosoma brucei | IC50 | 226.7000 | 1 | 1 |
| High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | Homo sapiens (human) | IC50 | 1.2843 | 7 | 7 |
| Histamine H2 receptor | Homo sapiens (human) | IC50 | 9.3960 | 1 | 1 |
| Histamine H2 receptor | Homo sapiens (human) | Ki | 9.2400 | 1 | 1 |
| Hypoxanthine-guanine phosphoribosyltransferase | Trypanosoma brucei brucei | Ki | 188.6000 | 1 | 1 |
| Ileal sodium/bile acid cotransporter | Homo sapiens (human) | Ki | 28.0000 | 1 | 1 |
| Inositol hexakisphosphate kinase 2 | Homo sapiens (human) | IC50 | 0.9000 | 1 | 1 |
| Inositol polyphosphate multikinase | Homo sapiens (human) | IC50 | 7.2000 | 1 | 1 |
| intestinal alkaline phosphatase precursor | Mus musculus (house mouse) | IC50 | 1.6600 | 1 | 1 |
| Kappa-type opioid receptor | Homo sapiens (human) | IC50 | 8.6155 | 1 | 2 |
| Kappa-type opioid receptor | Homo sapiens (human) | Ki | 3.4465 | 1 | 2 |
| Lysine-specific histone demethylase 1A | Homo sapiens (human) | IC50 | 14.3425 | 2 | 4 |
| Lysine-specific histone demethylase 1A | Homo sapiens (human) | Ki | 1.0000 | 1 | 1 |
| Macrophage metalloelastase | Homo sapiens (human) | IC50 | 121.0000 | 1 | 1 |
| Macrophage migration inhibitory factor | Homo sapiens (human) | IC50 | 255.0000 | 1 | 1 |
| Matrix metalloproteinase-14 | Homo sapiens (human) | IC50 | 12.6000 | 1 | 1 |
| Matrix metalloproteinase-9 | Homo sapiens (human) | IC50 | 186.0000 | 2 | 2 |
| Melanocortin receptor 3 | Homo sapiens (human) | IC50 | 19.8560 | 1 | 1 |
| Melanocortin receptor 3 | Homo sapiens (human) | Ki | 17.3290 | 1 | 1 |
| Melanocortin receptor 4 | Homo sapiens (human) | IC50 | 30.4810 | 1 | 1 |
| Melanocortin receptor 4 | Homo sapiens (human) | Ki | 29.3080 | 1 | 1 |
| Melanocortin receptor 5 | Homo sapiens (human) | IC50 | 26.5290 | 1 | 1 |
| Melanocortin receptor 5 | Homo sapiens (human) | Ki | 24.8860 | 1 | 1 |
| Mitogen-activated protein kinase 10 | Homo sapiens (human) | IC50 | 35.2200 | 1 | 5 |
| Mitogen-activated protein kinase 14 | Homo sapiens (human) | IC50 | 35.2200 | 1 | 5 |
| Mu-type opioid receptor | Homo sapiens (human) | IC50 | 9.3850 | 1 | 2 |
| Mu-type opioid receptor | Homo sapiens (human) | Ki | 3.8095 | 1 | 2 |
| Multidrug resistance-associated protein 1 | Homo sapiens (human) | IC50 | 3.0000 | 1 | 1 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 5 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | IC50 | 2.8290 | 1 | 1 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | Ki | 0.6810 | 1 | 1 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | IC50 | 7.7930 | 1 | 1 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | Ki | 2.7710 | 1 | 1 |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | IC50 | 2.9740 | 1 | 1 |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | Ki | 0.6300 | 1 | 1 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | IC50 | 4.8170 | 1 | 1 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | Ki | 0.6720 | 1 | 1 |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | IC50 | 2.5850 | 1 | 1 |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | Ki | 1.8570 | 1 | 1 |
| Neuraminidase | Influenza A virus (A/USSR/90/1977(H1N1)) | IC50 | 423.6500 | 2 | 2 |
| Neutrophil collagenase | Homo sapiens (human) | IC50 | 17.6000 | 1 | 1 |
| Nociceptin receptor | Mus musculus (house mouse) | Ki | 20,000.0000 | 1 | 1 |
| Nuclear receptor subfamily 3 group C member 3 | Bos taurus (cattle) | IC50 | 0.9670 | 1 | 1 |
| Nuclear receptor subfamily 3 group C member 3 | Bos taurus (cattle) | Ki | 0.7922 | 1 | 1 |
| Ornithine transcarbamylase, mitochondrial | Homo sapiens (human) | Ki | 16,333.3333 | 3 | 3 |
| Pancreatic triacylglycerol lipase | Sus scrofa (pig) | IC50 | 70.0000 | 1 | 1 |
| Phospholipase D1 | Homo sapiens (human) | IC50 | 9.0556 | 7 | 9 |
| Phospholipase D1 | Rattus norvegicus (Norway rat) | IC50 | 20.0000 | 1 | 2 |
| Phospholipase D2 | Homo sapiens (human) | IC50 | 7.6000 | 3 | 4 |
| Platelet-activating factor acetylhydrolase | Homo sapiens (human) | IC50 | 0.3015 | 2 | 3 |
| Platelet-activating factor receptor | Cavia porcellus (domestic guinea pig) | IC50 | 4.5000 | 1 | 1 |
| Polyphenol oxidase 2 | Agaricus bisporus | IC50 | 400.0000 | 1 | 1 |
| Polyunsaturated fatty acid 5-lipoxygenase | Homo sapiens (human) | Ki | 0.0844 | 2 | 2 |
| Polyunsaturated fatty acid lipoxygenase ALOX15 | Oryctolagus cuniculus (rabbit) | IC50 | 6.5890 | 1 | 1 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | IC50 | 1.2759 | 2 | 2 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | Ki | 0.7922 | 1 | 1 |
| Progesterone receptor | Homo sapiens (human) | IC50 | 33.4096 | 3 | 3 |
| Prostaglandin G/H synthase 1 | Homo sapiens (human) | IC50 | 3.6676 | 1 | 2 |
| Protein kinase C alpha type | Homo sapiens (human) | IC50 | 10.5000 | 2 | 2 |
| Protein kinase C alpha type | Rattus norvegicus (Norway rat) | IC50 | 75.0000 | 1 | 1 |
| Protein kinase C beta type | Homo sapiens (human) | IC50 | 10.5000 | 2 | 2 |
| Protein kinase C beta type | Rattus norvegicus (Norway rat) | IC50 | 75.0000 | 1 | 1 |
| Protein kinase C delta type | Homo sapiens (human) | IC50 | 10.5000 | 2 | 2 |
| Protein kinase C delta type | Rattus norvegicus (Norway rat) | IC50 | 75.0000 | 1 | 1 |
| Protein kinase C epsilon type | Homo sapiens (human) | IC50 | 10.5000 | 2 | 2 |
| Protein kinase C epsilon type | Rattus norvegicus (Norway rat) | IC50 | 75.0000 | 1 | 1 |
| Protein kinase C eta type | Homo sapiens (human) | IC50 | 10.5000 | 2 | 2 |
| Protein kinase C eta type | Rattus norvegicus (Norway rat) | IC50 | 75.0000 | 1 | 1 |
| Protein kinase C gamma type | Homo sapiens (human) | IC50 | 10.5000 | 2 | 2 |
| Protein kinase C gamma type | Rattus norvegicus (Norway rat) | IC50 | 75.0000 | 1 | 1 |
| Protein kinase C iota type | Homo sapiens (human) | IC50 | 10.5000 | 2 | 2 |
| Protein kinase C theta type | Homo sapiens (human) | IC50 | 10.5000 | 2 | 2 |
| Protein kinase C theta type | Rattus norvegicus (Norway rat) | IC50 | 75.0000 | 1 | 1 |
| Protein kinase C zeta type | Homo sapiens (human) | IC50 | 10.5000 | 2 | 2 |
| Protein kinase C zeta type | Rattus norvegicus (Norway rat) | IC50 | 75.0000 | 1 | 1 |
| Protein tyrosine phosphatase type IVA 3 | Homo sapiens (human) | IC50 | 46.2000 | 1 | 1 |
| Receptor tyrosine-protein kinase erbB-2 | Homo sapiens (human) | IC50 | 2.9490 | 1 | 1 |
| Receptor-type tyrosine-protein kinase FLT3 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Replicase polyprotein 1a | Severe acute respiratory syndrome-related coronavirus | IC50 | 38.4000 | 1 | 1 |
| Replicase polyprotein 1ab | Human coronavirus 229E | IC50 | 38.4000 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | IC50 | 20.9900 | 2 | 2 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | IC50 | 38.4000 | 3 | 3 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | Ki | 35.6000 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | Ki | 35.6000 | 2 | 2 |
| sentrin-specific protease 8 | Homo sapiens (human) | IC50 | 94.8000 | 1 | 1 |
| Serine/threonine-protein kinase D1 | Homo sapiens (human) | IC50 | 10.5000 | 2 | 2 |
| Serine/threonine-protein kinase D3 | Homo sapiens (human) | IC50 | 10.5000 | 2 | 2 |
| Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | Homo sapiens (human) | IC50 | 30.5730 | 1 | 1 |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | IC50 | 0.3510 | 1 | 2 |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | Ki | 0.0919 | 2 | 4 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | IC50 | 1.8550 | 1 | 2 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | Ki | 1.4735 | 1 | 2 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | IC50 | 1.4222 | 1 | 3 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | Ki | 1.4102 | 1 | 3 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | IC50 | 2.8254 | 1 | 4 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | Ki | 1.5010 | 1 | 4 |
| Solute carrier organic anion transporter family member 1A1 | Rattus norvegicus (Norway rat) | Ki | 15.7000 | 1 | 1 |
| Steroid hormone receptor ERR1 | Homo sapiens (human) | IC50 | 0.2000 | 1 | 1 |
| Sterol regulatory element-binding protein 1 | Homo sapiens (human) | IC50 | 1.1760 | 1 | 1 |
| Steryl-sulfatase | Homo sapiens (human) | IC50 | 51.0000 | 1 | 1 |
| Stromelysin-1 | Homo sapiens (human) | IC50 | 300.0000 | 1 | 1 |
| Substance-K receptor | Homo sapiens (human) | IC50 | 3.8295 | 1 | 2 |
| Substance-K receptor | Homo sapiens (human) | Ki | 1.2765 | 1 | 2 |
| Substance-P receptor | Homo sapiens (human) | IC50 | 15.6560 | 1 | 1 |
| Substance-P receptor | Homo sapiens (human) | Ki | 8.5400 | 1 | 1 |
| SUMO-1-specific protease | Homo sapiens (human) | IC50 | 57.2000 | 1 | 1 |
| SUMO1/sentrin specific peptidase 7 | Homo sapiens (human) | IC50 | 5.3500 | 1 | 1 |
| Thiosulfate sulfurtransferase | Homo sapiens (human) | IC50 | 94.0000 | 1 | 1 |
| Thromboxane-A synthase | Homo sapiens (human) | IC50 | 0.9160 | 1 | 1 |
| Transcriptional activator protein LuxR | Aliivibrio fischeri | IC50 | 40.0000 | 1 | 1 |
| Transporter | Rattus norvegicus (Norway rat) | Ki | 0.0001 | 1 | 1 |
| Type IV secretion-like conjugative transfer relaxase protein TraI | Escherichia coli SMS-3-5 | Ki | 0.0030 | 1 | 3 |
| Tyrosinase | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Tyrosine-protein kinase Fyn | Homo sapiens (human) | IC50 | 2.4305 | 1 | 2 |
| Tyrosine-protein kinase Lck | Homo sapiens (human) | IC50 | 8.0330 | 1 | 1 |
| ubiquitin-conjugating enzyme E2 N | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| Vitamin D3 receptor | Bos taurus (cattle) | IC50 | 0.0000 | 1 | 1 |
| Vitamin D3 receptor | Homo sapiens (human) | IC50 | 0.3401 | 19 | 19 |
| Vitamin D3 receptor | Rattus norvegicus (Norway rat) | Ki | 0.0001 | 11 | 11 |
| Xanthine dehydrogenase/oxidase | Homo sapiens (human) | IC50 | 25.9700 | 2 | 3 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial | Homo sapiens (human) | EC50 | 0.0030 | 1 | 1 |
| 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase | Homo sapiens (human) | Kd | 0.0010 | 1 | 1 |
| 7-dehydrocholesterol reductase | Homo sapiens (human) | Kd | 0.0010 | 1 | 1 |
| Angiotensin-converting enzyme 2 | Homo sapiens (human) | EC50 | 31.9650 | 1 | 4 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | EC50 | 56.5000 | 1 | 1 |
| Butyrophilin subfamily 3 member A1 | Homo sapiens (human) | EC50 | 41.1093 | 5 | 5 |
| Cannabinoid receptor 2 | Homo sapiens (human) | EC50 | 0.0983 | 4 | 4 |
| Chain A, Vitamin D Nuclear Receptor | Homo sapiens (human) | Kd | 0.0006 | 1 | 1 |
| Complement C5 | Homo sapiens (human) | Kd | 0.7100 | 1 | 1 |
| Envelope glycoprotein | Ebola virus - Mayinga, Zaire, 1976 | EC50 | 0.0628 | 2 | 2 |
| Envelope glycoprotein | Ebola virus - Mayinga, Zaire, 1976 | Kd | 16.0000 | 2 | 2 |
| Estrogen receptor | Homo sapiens (human) | EC50 | 0.4635 | 11 | 14 |
| Estrogen receptor | Rattus norvegicus (Norway rat) | EC50 | 150.0000 | 1 | 2 |
| Estrogen receptor beta | Homo sapiens (human) | EC50 | 0.4422 | 12 | 15 |
| Estrogen receptor beta | Rattus norvegicus (Norway rat) | EC50 | 150.0000 | 1 | 2 |
| G-protein coupled bile acid receptor 1 | Homo sapiens (human) | EC50 | 61.8833 | 3 | 3 |
| Glutamate receptor ionotropic, NMDA 1 | Rattus norvegicus (Norway rat) | Kd | 10.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2A | Rattus norvegicus (Norway rat) | Kd | 10.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2B | Rattus norvegicus (Norway rat) | Kd | 10.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2C | Rattus norvegicus (Norway rat) | Kd | 10.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2D | Rattus norvegicus (Norway rat) | Kd | 10.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3A | Rattus norvegicus (Norway rat) | Kd | 10.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3B | Rattus norvegicus (Norway rat) | Kd | 10.0000 | 1 | 1 |
| glycogen synthase kinase-3 beta isoform 1 | Homo sapiens (human) | EC50 | 15.8000 | 1 | 1 |
| HLA class I histocompatibility antigen, A alpha chain | Homo sapiens (human) | Kd | 22.0000 | 1 | 1 |
| Kappa-type opioid receptor | Cavia porcellus (domestic guinea pig) | EC50 | 0.0000 | 1 | 1 |
| Lysosomal acid glucosylceramidase | Homo sapiens (human) | EC50 | 2.5000 | 1 | 1 |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | EC50 | 0.0080 | 1 | 1 |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | EC50 | 0.0070 | 1 | 1 |
| Nuclear receptor subfamily 1 group I member 2 | Homo sapiens (human) | EC50 | 11.7100 | 1 | 1 |
| Phospholipase A2 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| Phospholipase D1 | Homo sapiens (human) | EC50 | 9.2500 | 2 | 2 |
| Procathepsin L | Homo sapiens (human) | EC50 | 31.9650 | 1 | 4 |
| Pyruvate kinase PKM | Homo sapiens (human) | EC50 | 0.0013 | 1 | 1 |
| Replicase polyprotein 1a | Severe acute respiratory syndrome-related coronavirus | EC50 | 31.9650 | 1 | 4 |
| Replicase polyprotein 1ab | Betacoronavirus England 1 | EC50 | 31.9650 | 1 | 4 |
| Replicase polyprotein 1ab | Human coronavirus 229E | EC50 | 31.9650 | 1 | 4 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | EC50 | 31.9650 | 1 | 4 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | EC50 | 31.9650 | 1 | 4 |
| Retinoic acid receptor RXR-alpha | Homo sapiens (human) | EC50 | 0.0016 | 1 | 1 |
| Sex hormone-binding globulin | Homo sapiens (human) | Kd | 0.0066 | 1 | 1 |
| signal transducer and activator of transcription 1-alpha/beta isoform alpha | Homo sapiens (human) | EC50 | 0.4180 | 1 | 1 |
| Spike glycoprotein | Betacoronavirus England 1 | EC50 | 31.9650 | 1 | 4 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | EC50 | 31.9650 | 1 | 4 |
| STAT3, partial | Homo sapiens (human) | EC50 | 55.7000 | 1 | 1 |
| streptokinase A precursor | Streptococcus pyogenes M1 GAS | EC50 | 78.0860 | 2 | 2 |
| Transmembrane protease serine 2 | Homo sapiens (human) | EC50 | 31.9650 | 1 | 4 |
| Vitamin D-binding protein | Homo sapiens (human) | Kd | 0.0240 | 1 | 1 |
| Vitamin D3 receptor | Bos taurus (cattle) | EC50 | 0.0001 | 2 | 2 |
| Vitamin D3 receptor | Homo sapiens (human) | EC50 | 0.0394 | 36 | 36 |
| Vitamin D3 receptor | Mus musculus (house mouse) | EC50 | 0.3500 | 1 | 2 |
| Vitamin D3 receptor | Rattus norvegicus (Norway rat) | EC50 | 0.0002 | 7 | 7 |
| Vitamin D3 receptor | Homo sapiens (human) | Kd | 0.0001 | 1 | 1 |
| Vitamin D3 receptor | Sus scrofa (pig) | Kd | 0.0001 | 1 | 1 |
| Vitamin D3 receptor A | Danio rerio (zebrafish) | EC50 | 0.0055 | 1 | 1 |
| Vitamin D3 receptor A | Danio rerio (zebrafish) | Kd | 1.2000 | 1 | 1 |