An EC 2.1.1.* (methyltransferases) inhibitor that interferes with the action of sterol methyltransferase.
ChEBI ID: 52303
| Member | Definition | Class |
|---|---|---|
| sitosterol, (3beta)-isomer | A member of the class of phytosterols that is stigmast-5-ene substituted by a beta-hydroxy group at position 3. | sitosterol |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (11.29) | 18.2507 |
| 2000's | 22 (35.48) | 29.6817 |
| 2010's | 27 (43.55) | 24.3611 |
| 2020's | 6 (9.68) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 3 (4.69%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 61 (95.31%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Cytochrome P450 2D6 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| DNA polymerase beta | Homo sapiens (human) | IC50 | 26.3000 | 1 | 1 |
| Prothrombin | Homo sapiens (human) | IC50 | 754.9250 | 4 | 4 |
| Prothrombin | Homo sapiens (human) | Ki | 0.2672 | 1 | 1 |