mTOR inhibitor

A protein kinase inhibitor of the mammalian target of rapamycin (mTOR), a protein that regulates cell growth, cell proliferation, cell motility, cell survival, protein synthesis and transcription. mTOR inhibitors are used to prevent transplant rejection and in treatment of cancer.

ChEBI ID: 68481

Members (13)

Member	Definition	Class
(5-(2,4-bis((3s)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol	A pyridopyrimidine that is pyrido[2,3-d]pyrimidine which is substituted at positions 2 and 4 by (3S)-3-methylmorpholin-4-yl groups and at position 5 by a 3-(hydroxymethyl)-4-methoxyphenyl group. It is an mTOR complex 1/2 (mTORC1/2) dual inhibitor [mTOR = mammalian target of rapamycin].	AZD-8055
bgt226	An imidazoquinoline that is 3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinoline substituted at position 1 by a 3-trifluoromethyl-4-(piperazin-1-yl)phenyl group and at position 8 by a 6-methoxypyridin-3-yl group. A dual PI3K/mTOR inhibitor.	BGT226 free base
dactolisib	An imidazoquinoline that is 3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinoline substituted at position 1 by a 4-(1-cyanoisopropyl)phenyl group and at position 8 by a quinolin-3-yl group. A dual PI3K/mTOR inhibitor used in cancer treatment.	dactolisib
everolimus	A macrocyclic lactone that is rapamycin in which the hydroxy group attached to the cyclohexyl moiety has been converted into the corresponding 2-hydroxyethyl ether. It is an immunosuppressant and antineoplastic agent.	everolimus
gsk 2126458	A member of the class of quinolines that is quinoline which is substituted by pyridazin-4-yl and 5-[(2,4-difluorobenzene-1-sulfonyl)amino]-6-methoxypyridin-3-yl groups at positions 4 and 6, respectively. It is a highly potent inhibitor of PI3K and mTOR developed by GlaxoSmithKline and was previously in human phase 1 clinical trials for the treatment of idiopathic pulmonary fibrosis and solid tumors.	omipalisib
ku 0063794	A member of the class of pyridopyrimidines that is an mTOR inhibitor and shows anti-tumour properties.	Ku-0063794
oleuropein aglycone	A secoiridoid that is the methyl ester of 3,4-dihydro-2H-pyran-5-carboxylic acid which is substituted at positions 2, 3, and 4 by hydroxy, ethylidene, and carboxymethyl groups, respectively and in which the carboxylic acid moiety of the carboxymethyl substituent has been converted to the corresponding 3,4-dihydroxyphenethyl ester (the 2R,3E,4S stereoisomer). The most important phenolic compound present in olive cultivars.	oleuropein aglycone
pi103	An organic heterotricyclic compound that is pyrido[3',2':4,5]furo[3,2-d]pyrimidine substituted at positions 2 and 4 by 3-hydroxyphenyl and morpholin-4-yl groups respectively. A dual-kinase inhibitor with anti-cancer properties.	PI-103
pp242	A member of the class of pyrazolopyrimidines that is 1H-pyrazolo[3,4-d]pyrimidine substituted by isopropyl, 5-hydroxyindol-2-yl and amino groups at positions 1, 3 and 4 respectively. It is a potent inhibitor of mTOR and exhibits anti-cancer properties.	torkinib
sirolimus	A macrolide lactam isolated from Streptomyces hygroscopicus consisting of a 29-membered ring containing 4 trans double bonds, three of which are conjugated. It is an antibiotic, immunosupressive and antineoplastic agent.	sirolimus
torin 1	A member of the class of pyridoquinolines that is 9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2-one bearing an additional 4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl substituent at position 1. It is a potent inhibitor of mTOR and exhibits anti-cancer properties.	torin 1
torin 2	A member of the class of pyridoquinolines that is benzo[h][1,6]naphthyridin-2-one carrying additional 3-(trifluoromethyl)phenyl and 6-aminopyridin-3-yl substituents at positions 1 and 9 respectively. It is a potent inhibitor of mTOR and exhibits anti-cancer properties.	torin 2
xl765	A sulfonamide obtained by formal condensation of the sulfonic acid group of 4-[(3-methoxy-4-methylbenzoyl)amino]benzenesulfonic acid with the primary aromatic amino group of N-(3,5-dimethoxyphenyl)quinoxaline-2,3-diamine. A dual PI3K/mTOR inhibitor used in cancer treatment.	XL765

Research

Studies (23,137)

Timeframe	Studies, Drugs with This Role(%)	All Drugs %
pre-1990	5 (0.02)	18.7374
1990's	1,169 (5.05)	18.2507
2000's	6,317 (27.30)	29.6817
2010's	12,472 (53.91)	24.3611
2020's	3,174 (13.72)	2.80

Study Types

Publication Type	Studies, Drugs with this Role (%)	All Drugs (%)
Trials	3,687 (13.45%)	5.53%
Reviews	3,056 (11.14%)	6.00%
Case Studies	2,127 (7.76%)	4.05%
Observational	332 (1.21%)	0.25%
Other	18,219 (66.44%)	84.16%

Protein Targets (595)

Potency Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
67.9K protein	Vaccinia virus	Potency	35.3249	2	4
activating transcription factor 6	Homo sapiens (human)	Potency	1.5089	1	1
Alpha-synuclein	Homo sapiens (human)	Potency	3.9811	1	1
AR protein	Homo sapiens (human)	Potency	19.2442	8	14
aryl hydrocarbon receptor	Homo sapiens (human)	Potency	3.6871	2	2
Ataxin-2	Homo sapiens (human)	Potency	18.0212	1	2
ATPase family AAA domain-containing protein 5	Homo sapiens (human)	Potency	19.6163	2	4
caspase 7, apoptosis-related cysteine protease	Homo sapiens (human)	Potency	29.8493	1	1
caspase-3	Cricetulus griseus (Chinese hamster)	Potency	23.7101	1	1
caspase-3	Homo sapiens (human)	Potency	29.8493	1	1
Caspase-7	Cricetulus griseus (Chinese hamster)	Potency	23.7101	1	1
Cellular tumor antigen p53	Homo sapiens (human)	Potency	25.7565	2	3
cytochrome P450 2C9, partial	Homo sapiens (human)	Potency	7.5259	1	6
cytochrome P450 2D6	Homo sapiens (human)	Potency	19.1936	1	4
cytochrome P450 family 3 subfamily A polypeptide 4	Homo sapiens (human)	Potency	3.2240	1	5
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	Homo sapiens (human)	Potency	0.1808	1	2
estrogen nuclear receptor alpha	Homo sapiens (human)	Potency	5.3847	8	13
estrogen receptor 2 (ER beta)	Homo sapiens (human)	Potency	30.0474	2	2
estrogen-related nuclear receptor alpha	Homo sapiens (human)	Potency	0.6063	6	6
EWS/FLI fusion protein	Homo sapiens (human)	Potency	2.5524	4	32
Fumarate hydratase	Homo sapiens (human)	Potency	3.1154	1	7
G	Vesicular stomatitis virus	Potency	7.5259	1	6
geminin	Homo sapiens (human)	Potency	30.1418	2	4
GLI family zinc finger 3	Homo sapiens (human)	Potency	1.2200	2	2
glucocorticoid receptor [Homo sapiens]	Homo sapiens (human)	Potency	7.7689	3	5
Glutamate receptor 2	Rattus norvegicus (Norway rat)	Potency	0.3758	1	1
heat shock protein beta-1	Homo sapiens (human)	Potency	2.1130	1	1
Histone H2A.x	Cricetulus griseus (Chinese hamster)	Potency	28.9710	2	2
HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)	Potency	7.5259	1	6
Inositol hexakisphosphate kinase 1	Homo sapiens (human)	Potency	7.5259	1	12
Interferon beta	Homo sapiens (human)	Potency	1.7763	3	34
nuclear factor erythroid 2-related factor 2 isoform 1	Homo sapiens (human)	Potency	18.4189	2	2
nuclear factor erythroid 2-related factor 2 isoform 2	Homo sapiens (human)	Potency	0.9200	1	1
nuclear receptor ROR-gamma isoform 1	Mus musculus (house mouse)	Potency	25.6464	2	4
nuclear receptor subfamily 1, group I, member 3	Homo sapiens (human)	Potency	10.5744	2	2
peripheral myelin protein 22	Rattus norvegicus (Norway rat)	Potency	32.1968	1	1
peroxisome proliferator activated receptor gamma	Homo sapiens (human)	Potency	16.8573	3	3
peroxisome proliferator-activated receptor delta	Homo sapiens (human)	Potency	8.4120	1	1
polyprotein	Zika virus	Potency	3.1154	1	7
PPM1D protein	Homo sapiens (human)	Potency	0.3902	1	18
pregnane X nuclear receptor	Homo sapiens (human)	Potency	9.8034	2	2
RAR-related orphan receptor gamma	Mus musculus (house mouse)	Potency	0.2699	2	2
retinoic acid nuclear receptor alpha variant 1	Homo sapiens (human)	Potency	2.1247	3	3
retinoid X nuclear receptor alpha	Homo sapiens (human)	Potency	12.9092	2	2
SMAD family member 2	Homo sapiens (human)	Potency	3.3780	1	1
SMAD family member 3	Homo sapiens (human)	Potency	3.3780	1	1
Smad3	Homo sapiens (human)	Potency	6.3944	1	2
TDP1 protein	Homo sapiens (human)	Potency	1.7515	2	8
thyroid hormone receptor beta isoform 2	Rattus norvegicus (Norway rat)	Potency	0.2463	3	5
thyroid stimulating hormone receptor	Homo sapiens (human)	Potency	11.8832	2	2
tyrosine-protein kinase Yes	Homo sapiens (human)	Potency	30.9516	1	2
USP1 protein, partial	Homo sapiens (human)	Potency	37.6460	1	2
vitamin D (1,25- dihydroxyvitamin D3) receptor	Homo sapiens (human)	Potency	10.8327	2	2
vitamin D3 receptor isoform VDRA	Homo sapiens (human)	Potency	39.8107	1	1
Voltage-dependent calcium channel gamma-2 subunit	Mus musculus (house mouse)	Potency	0.3758	1	1

Inhibition Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
Alpha-2A adrenergic receptor	Rattus norvegicus (Norway rat)	IC50	0.0061	1	2
Alpha-2B adrenergic receptor	Rattus norvegicus (Norway rat)	IC50	0.0061	1	2
Alpha-2C adrenergic receptor	Rattus norvegicus (Norway rat)	IC50	0.0061	1	2
ATP-binding cassette sub-family C member 3	Homo sapiens (human)	IC50	108.5000	1	2
ATP-dependent translocase ABCB1	Homo sapiens (human)	IC50	1.2500	1	1
Bile salt export pump	Homo sapiens (human)	IC50	6.6333	2	3
Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)	IC50	1.9000	1	1
Canalicular multispecific organic anion transporter 1	Homo sapiens (human)	IC50	72.1500	1	2
Chain A, PHOSPHOTIDYLINOSITOL 3 KINASE 59F	Drosophila melanogaster (fruit fly)	IC50	2.3000	1	4
Cytochrome P450 1A2	Homo sapiens (human)	IC50	0.0211	2	5
Cytochrome P450 2C19	Homo sapiens (human)	IC50	2.0070	2	2
Cytochrome P450 2C9	Homo sapiens (human)	IC50	2.0000	1	1
Cytochrome P450 2D6	Homo sapiens (human)	IC50	0.0790	1	1
Cytochrome P450 3A4	Homo sapiens (human)	IC50	0.2912	3	7
DNA-dependent protein kinase catalytic subunit	Homo sapiens (human)	IC50	1.7862	9	21
Ephrin type-B receptor 4	Homo sapiens (human)	IC50	2.7122	2	9
Epidermal growth factor receptor	Homo sapiens (human)	IC50	4.4000	1	1
Histone deacetylase 6	Homo sapiens (human)	IC50	0.0020	1	1
MAP kinase-interacting serine/threonine-protein kinase 2	Homo sapiens (human)	IC50	0.6200	1	1
Multidrug resistance-associated protein 4	Homo sapiens (human)	IC50	114.0000	1	2
Peptidyl-prolyl cis-trans isomerase FKBP1A	Homo sapiens (human)	IC50	0.0042	6	6
Peptidyl-prolyl cis-trans isomerase FKBP1A	Mus musculus (house mouse)	IC50	0.0010	1	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	Homo sapiens (human)	Ki	1.3505	4	4
Peptidyl-prolyl cis-trans isomerase FKBP5	Homo sapiens (human)	Ki	0.0030	1	1
Phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens (human)	IC50	0.3305	3	3
Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)	IC50	0.2893	26	31
Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)	Ki	0.0002	3	3
Phosphatidylinositol 4-kinase alpha	Homo sapiens (human)	IC50	10.0000	2	2
Phosphatidylinositol 4-kinase beta	Homo sapiens (human)	IC50	2.3688	3	3
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha	Homo sapiens (human)	IC50	0.3095	4	4
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	Homo sapiens (human)	IC50	0.1138	5	8
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)	IC50	0.7042	69	92
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Rattus norvegicus (Norway rat)	IC50	0.0053	1	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)	Ki	0.0000	2	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)	IC50	1.4059	40	54
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Rattus norvegicus (Norway rat)	IC50	0.0100	1	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)	Ki	0.0003	2	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)	IC50	0.6103	48	66
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)	Ki	0.0000	2	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)	IC50	1.3486	40	48
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)	Ki	0.0003	2	2
Phosphoinositide 3-kinase regulatory subunit 5	Homo sapiens (human)	IC50	0.1205	2	2
Platelet-derived growth factor receptor beta	Homo sapiens (human)	IC50	2.6263	1	8
Potassium voltage-gated channel subfamily D member 3	Homo sapiens (human)	IC50	10,000.0000	1	1
Potassium voltage-gated channel subfamily E member 1	Homo sapiens (human)	IC50	100.0000	1	1
Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)	IC50	3,436.6230	4	5
Potassium voltage-gated channel subfamily KQT member 1	Homo sapiens (human)	IC50	100.0000	1	1
Proto-oncogene tyrosine-protein kinase Src	Gallus gallus (chicken)	IC50	2.6262	1	8
Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)	IC50	2.4900	2	9
Rapamycin-insensitive companion of mTOR	Homo sapiens (human)	IC50	0.0280	5	7
Receptor protein-tyrosine kinase	Homo sapiens (human)	IC50	2.6262	1	8
Regulatory-associated protein of mTOR	Homo sapiens (human)	IC50	0.0963	9	13
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	Oryctolagus cuniculus (rabbit)	IC50	77.0000	1	1
Serine-protein kinase ATM	Homo sapiens (human)	IC50	0.0070	1	1
Serine/threonine-protein kinase ATR	Homo sapiens (human)	IC50	10.0000	1	1
Serine/threonine-protein kinase mTOR	Homo sapiens (human)	IC50	0.4682	77	106
Serine/threonine-protein kinase mTOR	Homo sapiens (human)	Ki	0.0108	2	4
Serine/threonine-protein kinase mTOR	Mus musculus (house mouse)	IC50	0.0010	2	2
Serine/threonine-protein kinase pim-1	Homo sapiens (human)	IC50	10.0000	1	1
Sodium channel protein type 5 subunit alpha	Homo sapiens (human)	IC50	415.2415	2	2
Solute carrier organic anion transporter family member 1B1	Homo sapiens (human)	IC50	1.1000	1	1
Target of rapamycin complex 2 subunit MAPKAP1	Homo sapiens (human)	IC50	0.0280	5	7
Target of rapamycin complex subunit LST8	Homo sapiens (human)	IC50	0.0724	14	20
Tyrosine-protein kinase ABL1	Homo sapiens (human)	IC50	2.5020	3	10
Tyrosine-protein kinase HCK	Homo sapiens (human)	IC50	2.4678	2	9
Tyrosine-protein kinase JAK3	Homo sapiens (human)	IC50	1.0000	1	1
Vascular endothelial growth factor receptor 2	Homo sapiens (human)	IC50	2.5011	2	9

Activation Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
26S proteasome regulatory subunit 6B	Homo sapiens (human)	Kd	30.0000	1	7
3-phosphoinositide-dependent protein kinase 1	Homo sapiens (human)	Kd	10.0000	2	3
5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)	Kd	23.3333	3	9
5'-AMP-activated protein kinase catalytic subunit alpha-2	Homo sapiens (human)	Kd	10.0000	2	3
5'-AMP-activated protein kinase subunit gamma-1	Homo sapiens (human)	Kd	30.0000	1	6
5'-AMP-activated protein kinase subunit gamma-2	Homo sapiens (human)	Kd	30.0000	1	6
AarF domain-containing protein kinase 1	Homo sapiens (human)	Kd	30.0000	1	6
Actin-related protein 2	Homo sapiens (human)	Kd	30.0000	1	6
Actin-related protein 3	Homo sapiens (human)	Kd	30.0000	1	6
Activated CDC42 kinase 1	Homo sapiens (human)	Kd	23.9600	3	10
Activin receptor type-1	Homo sapiens (human)	Kd	22.2227	3	9
Activin receptor type-1B	Homo sapiens (human)	Kd	22.2287	3	9
Activin receptor type-2A	Homo sapiens (human)	Kd	6.6727	2	3
Activin receptor type-2B	Homo sapiens (human)	Kd	22.2231	3	9
Acyl-CoA dehydrogenase family member 10	Homo sapiens (human)	Kd	30.0000	1	5
Acyl-CoA dehydrogenase family member 11	Homo sapiens (human)	Kd	30.0000	1	6
Adenine phosphoribosyltransferase	Homo sapiens (human)	Kd	30.0000	1	6
Adenosine kinase	Homo sapiens (human)	Kd	30.0000	1	6
Adenylate kinase 2, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	7
ADP/ATP translocase 2	Homo sapiens (human)	Kd	30.0000	1	6
ADP/ATP translocase 3	Homo sapiens (human)	Kd	30.0000	1	6
ALK tyrosine kinase receptor	Homo sapiens (human)	Kd	12.7750	3	4
Angiopoietin-1 receptor	Homo sapiens (human)	Kd	7.4000	2	3
Ankyrin repeat and protein kinase domain-containing protein 1	Homo sapiens (human)	Kd	7.5333	2	3
AP2-associated protein kinase 1	Homo sapiens (human)	Kd	22.4000	3	9
ATP-dependent 6-phosphofructokinase, platelet type	Homo sapiens (human)	Kd	30.0000	1	7
ATP-dependent RNA helicase DDX1	Homo sapiens (human)	Kd	30.0000	1	7
ATP-dependent RNA helicase DDX3X	Homo sapiens (human)	Kd	30.0000	1	6
ATP-dependent RNA helicase DDX42	Homo sapiens (human)	Kd	30.0000	1	4
ATP-dependent RNA helicase DHX30	Homo sapiens (human)	Kd	30.0000	1	4
Atypical kinase COQ8A, mitochondrial	Homo sapiens (human)	Kd	23.3200	3	10
Atypical kinase COQ8B, mitochondrial	Homo sapiens (human)	Kd	7.8333	2	3
Aurora kinase A	Homo sapiens (human)	Kd	23.3333	3	9
Aurora kinase B	Homo sapiens (human)	Kd	23.3333	3	9
Aurora kinase C	Homo sapiens (human)	Kd	10.0000	2	3
BDNF/NT-3 growth factors receptor	Homo sapiens (human)	Kd	7.6000	2	3
Beta-adrenergic receptor kinase 1	Homo sapiens (human)	Kd	30.0000	1	7
BMP-2-inducible protein kinase	Homo sapiens (human)	Kd	22.8889	3	9
Bone morphogenetic protein receptor type-1A	Homo sapiens (human)	Kd	22.2293	3	9
Bone morphogenetic protein receptor type-1B	Homo sapiens (human)	Kd	24.4447	2	9
Bone morphogenetic protein receptor type-2	Homo sapiens (human)	Kd	22.2321	3	9
Breakpoint cluster region protein	Homo sapiens (human)	Kd	30.0000	1	6
Bromodomain-containing protein 4	Homo sapiens (human)	Kd	1.7000	1	1
Calcium-dependent protein kinase 1	Plasmodium falciparum 3D7	Kd	5.2450	1	2
Calcium/calmodulin-dependent protein kinase kinase 1	Homo sapiens (human)	Kd	10.0000	2	3
Calcium/calmodulin-dependent protein kinase kinase 2	Homo sapiens (human)	Kd	23.9818	3	11
Calcium/calmodulin-dependent protein kinase type 1	Homo sapiens (human)	Kd	10.0000	2	3
Calcium/calmodulin-dependent protein kinase type 1D	Homo sapiens (human)	Kd	7.1667	2	3
Calcium/calmodulin-dependent protein kinase type 1G	Homo sapiens (human)	Kd	15.0000	3	4
Calcium/calmodulin-dependent protein kinase type II subunit alpha	Homo sapiens (human)	Kd	8.5333	2	3
Calcium/calmodulin-dependent protein kinase type II subunit beta	Homo sapiens (human)	Kd	10.0000	2	3
Calcium/calmodulin-dependent protein kinase type II subunit delta	Homo sapiens (human)	Kd	23.3333	3	9
Calcium/calmodulin-dependent protein kinase type II subunit gamma	Homo sapiens (human)	Kd	23.3333	3	9
Calcium/calmodulin-dependent protein kinase type IV	Homo sapiens (human)	Kd	24.0000	3	10
cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)	Kd	22.6333	3	9
cAMP-dependent protein kinase catalytic subunit beta	Homo sapiens (human)	Kd	23.3333	3	9
cAMP-dependent protein kinase catalytic subunit gamma	Homo sapiens (human)	Kd	30.0000	1	6
cAMP-dependent protein kinase catalytic subunit PRKX	Homo sapiens (human)	Kd	10.0000	2	3
cAMP-dependent protein kinase type II-alpha regulatory subunit	Homo sapiens (human)	Kd	30.0000	1	6
Casein kinase I isoform alpha	Homo sapiens (human)	Kd	24.4844	2	9
Casein kinase I isoform alpha-like	Homo sapiens (human)	Kd	7.3333	2	3
Casein kinase I isoform delta	Homo sapiens (human)	Kd	22.2578	3	9
Casein kinase I isoform epsilon	Homo sapiens (human)	Kd	23.0031	3	10
Casein kinase I isoform gamma-1	Homo sapiens (human)	Kd	21.7375	3	8
Casein kinase I isoform gamma-2	Homo sapiens (human)	Kd	20.4286	3	7
Casein kinase I isoform gamma-3	Homo sapiens (human)	Kd	22.5111	3	9
Casein kinase II subunit alpha	Homo sapiens (human)	Kd	5.5333	2	3
Casein kinase II subunit alpha'	Homo sapiens (human)	Kd	19.1474	3	9
Cell division control protein 2 homolog	Plasmodium falciparum 3D7	Kd	10.0000	1	2
Cell division cycle 7-related protein kinase	Homo sapiens (human)	Kd	30.0000	1	4
cGMP-dependent protein kinase 1	Homo sapiens (human)	Kd	24.0000	3	10
cGMP-dependent protein kinase 2	Homo sapiens (human)	Kd	6.8400	2	3
Choline-phosphate cytidylyltransferase A	Homo sapiens (human)	Kd	30.0000	1	4
Chromodomain-helicase-DNA-binding protein 4	Homo sapiens (human)	Kd	30.0000	1	6
Citron Rho-interacting kinase	Homo sapiens (human)	Kd	24.0000	3	10
Cyclin-dependent kinase 1	Homo sapiens (human)	Kd	30.0000	1	6
Cyclin-dependent kinase 11A	Homo sapiens (human)	Kd	10.0000	2	3
Cyclin-dependent kinase 11B	Homo sapiens (human)	Kd	10.0000	2	3
Cyclin-dependent kinase 12	Homo sapiens (human)	Kd	30.0000	1	6
Cyclin-dependent kinase 13	Homo sapiens (human)	Kd	25.0000	2	8
Cyclin-dependent kinase 14	Homo sapiens (human)	Kd	10.0000	2	3
Cyclin-dependent kinase 15	Homo sapiens (human)	Kd	10.0000	1	2
Cyclin-dependent kinase 16	Homo sapiens (human)	Kd	23.3333	3	9
Cyclin-dependent kinase 17	Homo sapiens (human)	Kd	23.3333	3	9
Cyclin-dependent kinase 18	Homo sapiens (human)	Kd	15.0000	3	4
Cyclin-dependent kinase 19	Homo sapiens (human)	Kd	7.5000	2	3
Cyclin-dependent kinase 2	Homo sapiens (human)	Kd	24.0000	3	10
Cyclin-dependent kinase 3	Homo sapiens (human)	Kd	22.5000	3	8
Cyclin-dependent kinase 4	Homo sapiens (human)	Kd	22.3545	3	11
Cyclin-dependent kinase 6	Homo sapiens (human)	Kd	30.0000	1	6
Cyclin-dependent kinase 7	Homo sapiens (human)	Kd	23.2700	3	10
Cyclin-dependent kinase 8	Homo sapiens (human)	Kd	8.7667	2	3
Cyclin-dependent kinase 9	Homo sapiens (human)	Kd	24.0000	3	10
Cyclin-dependent kinase-like 1	Homo sapiens (human)	Kd	10.0000	1	2
Cyclin-dependent kinase-like 2	Homo sapiens (human)	Kd	10.0000	1	2
Cyclin-dependent kinase-like 3	Homo sapiens (human)	Kd	10.0000	1	2
Cyclin-dependent kinase-like 5	Homo sapiens (human)	Kd	16.6667	2	3
Cyclin-dependent-like kinase 5	Homo sapiens (human)	Kd	23.3333	3	9
Cyclin-G-associated kinase	Homo sapiens (human)	Kd	22.2578	3	9
Cysteine--tRNA ligase, cytoplasmic	Homo sapiens (human)	Kd	30.0000	1	5
Cytochrome c1, heme protein, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	7
Cytoplasmic tyrosine-protein kinase BMX	Homo sapiens (human)	Kd	6.8900	2	3
dCTP pyrophosphatase 1	Homo sapiens (human)	Kd	30.0000	1	6
Death-associated protein kinase 1	Homo sapiens (human)	Kd	1.6323	2	3
Death-associated protein kinase 2	Homo sapiens (human)	Kd	1.8313	2	3
Death-associated protein kinase 3	Homo sapiens (human)	Kd	2.9302	3	4
Delta(24)-sterol reductase	Homo sapiens (human)	Kd	30.0000	1	7
Deoxycytidine kinase	Homo sapiens (human)	Kd	30.0000	1	6
Discoidin domain-containing receptor 2	Homo sapiens (human)	Kd	22.9000	3	9
DNA replication licensing factor MCM4	Homo sapiens (human)	Kd	30.0000	1	6
DNA topoisomerase 2-alpha	Homo sapiens (human)	Kd	30.0000	1	6
DNA topoisomerase 2-beta	Homo sapiens (human)	Kd	30.0000	1	6
DNA-dependent protein kinase catalytic subunit	Homo sapiens (human)	EC50	0.1180	1	1
DnaJ homolog subfamily A member 1	Homo sapiens (human)	Kd	30.0000	1	6
Dual serine/threonine and tyrosine protein kinase	Homo sapiens (human)	Kd	5.2550	1	2
Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)	Kd	22.2279	3	9
Dual specificity mitogen-activated protein kinase kinase 2	Homo sapiens (human)	Kd	22.2456	3	9
Dual specificity mitogen-activated protein kinase kinase 3	Homo sapiens (human)	Kd	23.0092	3	10
Dual specificity mitogen-activated protein kinase kinase 4	Homo sapiens (human)	Kd	12.7025	3	4
Dual specificity mitogen-activated protein kinase kinase 5	Homo sapiens (human)	Kd	23.7509	2	8
Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)	Kd	23.3333	3	9
Dual specificity mitogen-activated protein kinase kinase 7	Homo sapiens (human)	Kd	10.0000	1	2
Dual specificity protein kinase CLK1	Homo sapiens (human)	Kd	17.6618	3	9
Dual specificity protein kinase CLK2	Homo sapiens (human)	Kd	22.6500	3	10
Dual specificity protein kinase CLK3	Homo sapiens (human)	Kd	17.1800	3	5
Dual specificity protein kinase CLK4	Homo sapiens (human)	Kd	22.3111	3	9
Dual specificity protein kinase TTK	Homo sapiens (human)	Kd	23.6936	3	11
Dual specificity testis-specific protein kinase 1	Homo sapiens (human)	Kd	22.2556	3	9
Dual specificity testis-specific protein kinase 2	Homo sapiens (human)	Kd	30.0000	1	4
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Homo sapiens (human)	Kd	20.4027	2	8
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	Homo sapiens (human)	Kd	17.1400	3	5
Dual specificity tyrosine-phosphorylation-regulated kinase 2	Homo sapiens (human)	Kd	2.0795	1	2
Dynamin-like 120 kDa protein, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	7
eIF-2-alpha kinase GCN2	Homo sapiens (human)	Kd	10.0000	2	3
EKC/KEOPS complex subunit TP53RK	Homo sapiens (human)	Kd	25.8584	1	7
Electron transfer flavoprotein subunit beta	Homo sapiens (human)	Kd	30.0000	1	6
Elongation factor Tu, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	6
Ephrin type-A receptor 1	Homo sapiens (human)	Kd	21.2624	3	8
Ephrin type-A receptor 2	Homo sapiens (human)	Kd	22.2911	3	9
Ephrin type-A receptor 3	Homo sapiens (human)	Kd	6.7967	2	3
Ephrin type-A receptor 4	Homo sapiens (human)	Kd	22.3311	3	9
Ephrin type-A receptor 5	Homo sapiens (human)	Kd	23.3100	3	10
Ephrin type-A receptor 6	Homo sapiens (human)	Kd	6.7367	2	3
Ephrin type-A receptor 7	Homo sapiens (human)	Kd	21.4286	3	7
Ephrin type-A receptor 8	Homo sapiens (human)	Kd	6.7500	2	3
Ephrin type-B receptor 1	Homo sapiens (human)	Kd	7.3000	2	3
Ephrin type-B receptor 2	Homo sapiens (human)	Kd	22.2844	3	9
Ephrin type-B receptor 3	Homo sapiens (human)	Kd	23.3333	3	9
Ephrin type-B receptor 4	Homo sapiens (human)	Kd	24.0000	3	10
Ephrin type-B receptor 6	Homo sapiens (human)	Kd	24.8750	2	8
Epidermal growth factor receptor	Homo sapiens (human)	Kd	10.5930	23	40
Epithelial discoidin domain-containing receptor 1	Homo sapiens (human)	Kd	23.0740	3	10
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B	Homo sapiens (human)	Kd	30.0000	1	2
Eukaryotic translation initiation factor 2-alpha kinase 1	Homo sapiens (human)	Kd	25.0000	2	8
Eukaryotic translation initiation factor 4E	Homo sapiens (human)	Kd	0.0005	1	1
Eukaryotic translation initiation factor 5B	Homo sapiens (human)	Kd	30.0000	1	6
Exosome RNA helicase MTR4	Homo sapiens (human)	Kd	30.0000	1	6
Ferrochelatase, mitochondrial	Homo sapiens (human)	Kd	17.4505	2	8
Fibroblast growth factor receptor 1	Homo sapiens (human)	Kd	23.0570	3	10
Fibroblast growth factor receptor 2	Homo sapiens (human)	Kd	6.7367	2	3
Fibroblast growth factor receptor 3	Homo sapiens (human)	Kd	6.9050	4	6
Fibroblast growth factor receptor 4	Homo sapiens (human)	Kd	7.0333	2	3
Focal adhesion kinase 1	Homo sapiens (human)	Kd	23.3333	3	9
G protein-coupled receptor kinase 4	Homo sapiens (human)	Kd	10.0000	1	2
G protein-coupled receptor kinase 6	Homo sapiens (human)	Kd	30.0000	1	5
General transcription and DNA repair factor IIH helicase subunit XPD	Homo sapiens (human)	Kd	30.0000	1	6
Glycine--tRNA ligase	Homo sapiens (human)	Kd	30.0000	1	6
Glycogen phosphorylase, brain form	Homo sapiens (human)	Kd	30.0000	1	6
Glycogen phosphorylase, liver form	Homo sapiens (human)	Kd	30.0000	1	6
Glycogen synthase kinase-3 alpha	Homo sapiens (human)	Kd	21.3403	3	10
Glycogen synthase kinase-3 beta	Homo sapiens (human)	Kd	23.3333	3	9
GTP-binding nuclear protein Ran	Homo sapiens (human)	Kd	30.0000	1	6
Guanine nucleotide-binding protein G(i) subunit alpha-2	Homo sapiens (human)	Kd	30.0000	1	4
Heme oxygenase 2	Homo sapiens (human)	Kd	30.0000	1	6
Hepatocyte growth factor receptor	Homo sapiens (human)	Kd	18.3333	5	12
High affinity nerve growth factor receptor	Homo sapiens (human)	Kd	22.3250	3	8
Homeodomain-interacting protein kinase 1	Homo sapiens (human)	Kd	1.8000	1	2
Homeodomain-interacting protein kinase 2	Homo sapiens (human)	Kd	0.3200	1	2
Homeodomain-interacting protein kinase 3	Homo sapiens (human)	Kd	0.2200	1	2
Homeodomain-interacting protein kinase 4	Homo sapiens (human)	Kd	6.1000	1	2
Hormonally up-regulated neu tumor-associated kinase	Homo sapiens (human)	Kd	10.0000	1	2
Inhibitor of nuclear factor kappa-B kinase subunit alpha	Homo sapiens (human)	Kd	5.8500	1	2
Inhibitor of nuclear factor kappa-B kinase subunit beta	Homo sapiens (human)	Kd	10.0000	1	2
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	Homo sapiens (human)	Kd	23.3333	3	9
Inosine-5'-monophosphate dehydrogenase 2	Homo sapiens (human)	Kd	30.0000	1	6
Insulin receptor	Homo sapiens (human)	Kd	24.0000	3	10
Insulin receptor-related protein	Homo sapiens (human)	Kd	10.0000	2	3
Insulin-like growth factor 1 receptor	Homo sapiens (human)	Kd	24.5455	3	11
Integrin-linked protein kinase	Homo sapiens (human)	Kd	30.0000	1	6
Interferon-induced, double-stranded RNA-activated protein kinase	Homo sapiens (human)	Kd	7.4000	2	3
Interleukin-1 receptor-associated kinase 1	Homo sapiens (human)	Kd	24.2125	2	8
Interleukin-1 receptor-associated kinase 3	Homo sapiens (human)	Kd	20.4033	3	10
Interleukin-1 receptor-associated kinase 4	Homo sapiens (human)	Kd	24.9222	2	9
Isoleucine--tRNA ligase, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	5
Leucine-rich repeat serine/threonine-protein kinase 2	Homo sapiens (human)	Kd	5.4975	2	4
Leukocyte tyrosine kinase receptor	Homo sapiens (human)	Kd	7.1333	2	3
Leukotriene C4 synthase	Cavia porcellus (domestic guinea pig)	Kd	6.9500	1	2
LIM domain kinase 1	Homo sapiens (human)	Kd	23.3333	3	9
LIM domain kinase 2	Homo sapiens (human)	Kd	21.8889	3	9
Long-chain-fatty-acid--CoA ligase 5	Homo sapiens (human)	Kd	30.0000	1	3
Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)	Kd	7.7667	2	3
Macrophage-stimulating protein receptor	Homo sapiens (human)	Kd	25.0000	2	8
MAP kinase-activated protein kinase 2	Homo sapiens (human)	Kd	23.3333	3	9
MAP kinase-activated protein kinase 3	Homo sapiens (human)	Kd	30.0000	1	2
MAP kinase-activated protein kinase 5	Homo sapiens (human)	Kd	23.3333	3	9
MAP kinase-interacting serine/threonine-protein kinase 1	Homo sapiens (human)	Kd	8.9000	2	3
MAP kinase-interacting serine/threonine-protein kinase 2	Homo sapiens (human)	Kd	6.9400	2	3
MAP/microtubule affinity-regulating kinase 3	Homo sapiens (human)	Kd	24.0000	3	10
MAP/microtubule affinity-regulating kinase 4	Homo sapiens (human)	Kd	24.0000	3	10
Mast/stem cell growth factor receptor Kit	Homo sapiens (human)	Kd	8.2504	16	24
Maternal embryonic leucine zipper kinase	Homo sapiens (human)	Kd	19.3612	3	9
Megakaryocyte-associated tyrosine-protein kinase	Homo sapiens (human)	Kd	10.0000	1	2
Membrane-associated progesterone receptor component 1	Homo sapiens (human)	Kd	30.0000	1	6
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens (human)	Kd	23.3333	3	9
Microtubule-associated serine/threonine-protein kinase 1	Homo sapiens (human)	Kd	10.0000	1	2
Midasin	Homo sapiens (human)	Kd	30.0000	1	6
Misshapen-like kinase 1	Homo sapiens (human)	Kd	22.8829	2	7
Mitogen-activated protein kinase 1	Homo sapiens (human)	Kd	23.3333	3	9
Mitogen-activated protein kinase 10	Homo sapiens (human)	Kd	23.3333	3	9
Mitogen-activated protein kinase 11	Homo sapiens (human)	Kd	24.0000	3	10
Mitogen-activated protein kinase 12	Homo sapiens (human)	Kd	10.0000	2	3
Mitogen-activated protein kinase 13	Homo sapiens (human)	Kd	10.0000	1	2
Mitogen-activated protein kinase 14	Homo sapiens (human)	Kd	24.0000	3	10
Mitogen-activated protein kinase 15	Homo sapiens (human)	Kd	24.5455	3	11
Mitogen-activated protein kinase 3	Homo sapiens (human)	Kd	24.0000	3	10
Mitogen-activated protein kinase 4	Homo sapiens (human)	Kd	10.0000	2	3
Mitogen-activated protein kinase 6	Homo sapiens (human)	Kd	10.0000	2	3
Mitogen-activated protein kinase 7	Homo sapiens (human)	Kd	23.3333	3	9
Mitogen-activated protein kinase 8	Homo sapiens (human)	Kd	23.3333	3	9
Mitogen-activated protein kinase 9	Homo sapiens (human)	Kd	23.3333	3	9
Mitogen-activated protein kinase kinase kinase 1	Homo sapiens (human)	Kd	24.0625	2	8
Mitogen-activated protein kinase kinase kinase 10	Homo sapiens (human)	Kd	10.0000	2	3
Mitogen-activated protein kinase kinase kinase 11	Homo sapiens (human)	Kd	23.3333	3	9
Mitogen-activated protein kinase kinase kinase 12	Homo sapiens (human)	Kd	10.0000	1	2
Mitogen-activated protein kinase kinase kinase 13	Homo sapiens (human)	Kd	10.0000	1	2
Mitogen-activated protein kinase kinase kinase 15	Homo sapiens (human)	Kd	10.0000	1	2
Mitogen-activated protein kinase kinase kinase 19	Homo sapiens (human)	Kd	0.4676	1	2
Mitogen-activated protein kinase kinase kinase 2	Homo sapiens (human)	Kd	23.8588	2	8
Mitogen-activated protein kinase kinase kinase 20	Homo sapiens (human)	Kd	23.1800	3	10
Mitogen-activated protein kinase kinase kinase 3	Homo sapiens (human)	Kd	24.5156	2	9
Mitogen-activated protein kinase kinase kinase 4	Homo sapiens (human)	Kd	24.0000	3	10
Mitogen-activated protein kinase kinase kinase 5	Homo sapiens (human)	Kd	23.3333	3	9
Mitogen-activated protein kinase kinase kinase 6	Homo sapiens (human)	Kd	25.0000	2	8
Mitogen-activated protein kinase kinase kinase 7	Homo sapiens (human)	Kd	5.8000	1	2
Mitogen-activated protein kinase kinase kinase 9	Homo sapiens (human)	Kd	7.6333	2	3
Mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens (human)	Kd	22.4556	3	9
Mitogen-activated protein kinase kinase kinase kinase 2	Homo sapiens (human)	Kd	23.7625	2	8
Mitogen-activated protein kinase kinase kinase kinase 3	Homo sapiens (human)	Kd	23.3333	3	9
Mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens (human)	Kd	22.3667	3	9
Mitogen-activated protein kinase kinase kinase kinase 5	Homo sapiens (human)	Kd	24.5455	3	11
Mitotic checkpoint serine/threonine-protein kinase BUB1	Homo sapiens (human)	Kd	30.0000	1	5
Multifunctional protein ADE2	Homo sapiens (human)	Kd	30.0000	1	6
Muscle, skeletal receptor tyrosine-protein kinase	Homo sapiens (human)	Kd	10.0000	2	3
Myosin light chain kinase 2, skeletal/cardiac muscle	Homo sapiens (human)	Kd	10.0000	2	3
Myosin light chain kinase 3	Homo sapiens (human)	Kd	20.1831	2	8
Myosin light chain kinase family member 4	Homo sapiens (human)	Kd	10.0000	2	3
Myosin light chain kinase, smooth muscle	Gallus gallus (chicken)	Kd	10.0000	1	1
Myosin light chain kinase, smooth muscle	Homo sapiens (human)	Kd	22.1209	3	11
Myosin-10	Homo sapiens (human)	Kd	30.0000	1	7
Myosin-14	Homo sapiens (human)	Kd	30.0000	1	6
Myosin-IIIa	Homo sapiens (human)	Kd	6.9433	2	3
Myosin-IIIb	Homo sapiens (human)	Kd	7.3667	2	3
Myotonin-protein kinase	Homo sapiens (human)	Kd	6.7133	2	3
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	Homo sapiens (human)	Kd	30.0000	1	5
Non-receptor tyrosine-protein kinase TNK1	Homo sapiens (human)	Kd	22.3556	3	9
Non-receptor tyrosine-protein kinase TYK2	Homo sapiens (human)	Kd	19.0527	4	11
NT-3 growth factor receptor	Homo sapiens (human)	Kd	10.0000	2	3
NUAK family SNF1-like kinase 1	Homo sapiens (human)	Kd	10.0000	2	3
NUAK family SNF1-like kinase 2	Homo sapiens (human)	Kd	21.7000	3	8
Nuclear receptor subfamily 1 group I member 2	Homo sapiens (human)	EC50	5.4450	2	2
Nucleolar GTP-binding protein 1	Homo sapiens (human)	Kd	30.0000	1	6
Nucleoside diphosphate kinase B	Homo sapiens (human)	Kd	30.0000	1	1
Obg-like ATPase 1	Homo sapiens (human)	Kd	30.0000	1	6
PAS domain-containing serine/threonine-protein kinase	Homo sapiens (human)	Kd	30.0000	1	5
Peptidyl-prolyl cis-trans isomerase FKBP1A	Homo sapiens (human)	EC50	0.0364	1	1
Peptidyl-prolyl cis-trans isomerase FKBP1B	Homo sapiens (human)	Kd	0.0002	1	1
Peripheral plasma membrane protein CASK	Homo sapiens (human)	Kd	5.8000	1	2
Peroxisomal acyl-coenzyme A oxidase 1	Homo sapiens (human)	Kd	30.0000	1	5
Peroxisomal acyl-coenzyme A oxidase 3	Homo sapiens (human)	Kd	30.0000	1	6
Phenylalanine--tRNA ligase beta subunit	Homo sapiens (human)	Kd	30.0000	1	6
Phosphatidylethanolamine-binding protein 1	Homo sapiens (human)	Kd	30.0000	1	6
Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)	EC50	0.0400	1	1
Phosphatidylinositol 4-kinase beta	Homo sapiens (human)	Kd	1.7933	2	3
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	Homo sapiens (human)	Kd	0.1150	1	2
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	Homo sapiens (human)	Kd	0.0955	1	2
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha	Homo sapiens (human)	Kd	10.0000	2	3
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma	Homo sapiens (human)	Kd	5.0090	1	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)	EC50	0.5200	3	4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)	Kd	0.1068	15	25
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)	EC50	0.0150	2	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)	Kd	0.0806	2	3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)	EC50	0.0930	2	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)	Kd	0.0263	2	3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)	EC50	0.0670	2	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)	Kd	0.0333	2	3
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	Homo sapiens (human)	Kd	30.0000	1	5
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	Homo sapiens (human)	Kd	10.0000	2	3
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	Homo sapiens (human)	Kd	15.9459	2	8
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	Homo sapiens (human)	Kd	22.3067	3	9
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform	Homo sapiens (human)	Kd	10.0000	2	3
Platelet-derived growth factor receptor alpha	Homo sapiens (human)	Kd	6.7400	2	3
Platelet-derived growth factor receptor beta	Homo sapiens (human)	Kd	23.0078	3	10
Probable ATP-dependent RNA helicase DDX6	Homo sapiens (human)	Kd	30.0000	1	6
Programmed cell death protein 4	Homo sapiens (human)	EC50	0.0500	1	1
Prostaglandin G/H synthase 2	Homo sapiens (human)	Kd	10.0000	1	2
Protein kinase C alpha type	Homo sapiens (human)	Kd	30.0000	1	7
Protein kinase C beta type	Homo sapiens (human)	Kd	30.0000	1	7
Protein kinase C delta type	Homo sapiens (human)	Kd	23.3333	3	9
Protein kinase C epsilon type	Homo sapiens (human)	Kd	6.6697	2	3
Protein kinase C eta type	Homo sapiens (human)	Kd	6.9367	2	3
Protein kinase C iota type	Homo sapiens (human)	Kd	25.0000	2	8
Protein kinase C theta type	Homo sapiens (human)	Kd	23.3333	3	9
Protein kinase C zeta type	Homo sapiens (human)	Kd	30.0000	1	5
Protein-tyrosine kinase 2-beta	Homo sapiens (human)	Kd	23.3333	3	9
Protein-tyrosine kinase 6	Homo sapiens (human)	Kd	22.3333	3	9
Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)	Kd	15.0437	7	16
Proto-oncogene tyrosine-protein kinase ROS	Homo sapiens (human)	Kd	7.0667	2	3
Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)	Kd	22.2467	3	9
Putative heat shock protein HSP 90-beta 2	Homo sapiens (human)	Kd	30.0000	1	7
Putative nucleoside diphosphate kinase	Homo sapiens (human)	Kd	30.0000	1	1
Pyridoxal kinase	Homo sapiens (human)	Kd	30.0000	1	6
Rab-like protein 3	Homo sapiens (human)	Kd	30.0000	1	3
RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)	Kd	23.3333	3	9
RAC-beta serine/threonine-protein kinase	Homo sapiens (human)	Kd	23.3333	3	9
RAC-gamma serine/threonine-protein kinase	Homo sapiens (human)	Kd	22.5111	3	9
RAF proto-oncogene serine/threonine-protein kinase	Homo sapiens (human)	Kd	5.8000	2	3
Ras-related protein Rab-10	Homo sapiens (human)	Kd	30.0000	1	6
Ras-related protein Rab-27A	Homo sapiens (human)	Kd	30.0000	1	6
Ras-related protein Rab-6A	Homo sapiens (human)	Kd	30.0000	1	6
Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)	Kd	7.6333	2	3
Receptor tyrosine-protein kinase erbB-3	Homo sapiens (human)	Kd	5.0600	1	2
Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)	Kd	10.0000	1	2
Receptor-interacting serine/threonine-protein kinase 1	Homo sapiens (human)	Kd	10.0000	2	3
Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)	Kd	23.0077	3	10
Receptor-interacting serine/threonine-protein kinase 3	Homo sapiens (human)	Kd	30.0000	1	6
Receptor-interacting serine/threonine-protein kinase 4	Homo sapiens (human)	Kd	5.1450	1	2
Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)	Kd	12.0956	13	25
Regulatory-associated protein of mTOR	Homo sapiens (human)	EC50	0.0002	1	1
Rho-associated protein kinase 1	Homo sapiens (human)	Kd	25.5556	2	9
Rho-associated protein kinase 2	Homo sapiens (human)	Kd	25.5556	2	9
Rhodopsin kinase GRK1	Homo sapiens (human)	Kd	5.4650	1	2
Rhodopsin kinase GRK7	Homo sapiens (human)	Kd	5.7000	1	2
Ribosomal protein S6 kinase alpha-1	Homo sapiens (human)	Kd	19.3417	5	12
Ribosomal protein S6 kinase alpha-2	Homo sapiens (human)	Kd	10.0000	4	6
Ribosomal protein S6 kinase alpha-3	Homo sapiens (human)	Kd	22.2444	3	9
Ribosomal protein S6 kinase alpha-4	Homo sapiens (human)	Kd	19.1721	5	12
Ribosomal protein S6 kinase alpha-5	Homo sapiens (human)	Kd	19.2917	5	12
Ribosomal protein S6 kinase alpha-6	Homo sapiens (human)	Kd	19.8392	5	13
Ribosomal protein S6 kinase beta-1	Homo sapiens (human)	Kd	23.5429	2	7
Ribosyldihydronicotinamide dehydrogenase [quinone]	Homo sapiens (human)	Kd	30.0000	1	6
RNA cytidine acetyltransferase	Homo sapiens (human)	Kd	30.0000	1	7
S-adenosylmethionine synthase isoform type-2	Homo sapiens (human)	Kd	30.0000	1	6
Septin-9	Homo sapiens (human)	Kd	30.0000	1	6
Serine-protein kinase ATM	Homo sapiens (human)	EC50	0.0280	1	1
Serine/threonine-protein kinase 10	Homo sapiens (human)	Kd	22.2308	3	9
Serine/threonine-protein kinase 16	Homo sapiens (human)	Kd	22.6667	3	9
Serine/threonine-protein kinase 17A	Homo sapiens (human)	Kd	10.0000	2	3
Serine/threonine-protein kinase 17B	Homo sapiens (human)	Kd	7.7333	2	3
Serine/threonine-protein kinase 24	Homo sapiens (human)	Kd	22.5000	3	8
Serine/threonine-protein kinase 25	Homo sapiens (human)	Kd	10.0000	2	3
Serine/threonine-protein kinase 26	Homo sapiens (human)	Kd	22.6333	3	9
Serine/threonine-protein kinase 3	Homo sapiens (human)	Kd	22.5111	3	9
Serine/threonine-protein kinase 32A	Homo sapiens (human)	Kd	5.3450	1	2
Serine/threonine-protein kinase 32B	Homo sapiens (human)	Kd	7.1333	2	3
Serine/threonine-protein kinase 32C	Homo sapiens (human)	Kd	10.0000	2	3
Serine/threonine-protein kinase 33	Homo sapiens (human)	Kd	8.1667	2	3
Serine/threonine-protein kinase 35	Homo sapiens (human)	Kd	5.2500	1	2
Serine/threonine-protein kinase 36	Homo sapiens (human)	Kd	10.0000	2	3
Serine/threonine-protein kinase 38	Homo sapiens (human)	Kd	20.0000	2	4
Serine/threonine-protein kinase 38-like	Homo sapiens (human)	Kd	20.0000	3	6
Serine/threonine-protein kinase 4	Homo sapiens (human)	Kd	23.3333	3	9
Serine/threonine-protein kinase A-Raf	Homo sapiens (human)	Kd	30.0000	1	6
Serine/threonine-protein kinase ATR	Homo sapiens (human)	EC50	0.0350	1	1
Serine/threonine-protein kinase ATR	Homo sapiens (human)	Kd	30.0000	1	3
Serine/threonine-protein kinase B-raf	Homo sapiens (human)	Kd	16.0733	5	12
Serine/threonine-protein kinase BRSK1	Homo sapiens (human)	Kd	6.6713	2	3
Serine/threonine-protein kinase BRSK2	Homo sapiens (human)	Kd	6.6807	2	3
Serine/threonine-protein kinase Chk1	Homo sapiens (human)	Kd	23.3333	3	9
Serine/threonine-protein kinase Chk2	Homo sapiens (human)	Kd	6.4500	1	2
Serine/threonine-protein kinase D1	Homo sapiens (human)	Kd	10.0000	2	3
Serine/threonine-protein kinase D2	Homo sapiens (human)	Kd	23.3333	3	9
Serine/threonine-protein kinase D3	Homo sapiens (human)	Kd	23.3333	3	9
Serine/threonine-protein kinase DCLK1	Homo sapiens (human)	Kd	10.0000	2	3
Serine/threonine-protein kinase DCLK2	Homo sapiens (human)	Kd	10.0000	2	3
Serine/threonine-protein kinase DCLK3	Homo sapiens (human)	Kd	6.9400	2	3
Serine/threonine-protein kinase ICK	Homo sapiens (human)	Kd	24.2857	2	7
Serine/threonine-protein kinase LATS1	Homo sapiens (human)	Kd	23.3333	3	9
Serine/threonine-protein kinase LATS2	Homo sapiens (human)	Kd	8.0000	2	3
Serine/threonine-protein kinase MAK	Homo sapiens (human)	Kd	10.0000	1	2
Serine/threonine-protein kinase MARK1	Homo sapiens (human)	Kd	10.0000	2	3
Serine/threonine-protein kinase MARK2	Homo sapiens (human)	Kd	22.9111	3	9
Serine/threonine-protein kinase MRCK alpha	Homo sapiens (human)	Kd	21.2364	4	11
Serine/threonine-protein kinase MRCK beta	Homo sapiens (human)	Kd	24.0000	3	10
Serine/threonine-protein kinase MRCK gamma	Homo sapiens (human)	Kd	23.3333	3	9
Serine/threonine-protein kinase mTOR	Homo sapiens (human)	EC50	0.0002	1	1
Serine/threonine-protein kinase mTOR	Homo sapiens (human)	Kd	0.0035	4	6
Serine/threonine-protein kinase mTOR	Mus musculus (house mouse)	EC50	0.0011	1	2
Serine/threonine-protein kinase N1	Homo sapiens (human)	Kd	23.3333	3	9
Serine/threonine-protein kinase N2	Homo sapiens (human)	Kd	23.3333	3	9
Serine/threonine-protein kinase N3	Homo sapiens (human)	Kd	30.0000	1	4
Serine/threonine-protein kinase Nek1	Homo sapiens (human)	Kd	23.3333	3	9
Serine/threonine-protein kinase Nek11	Homo sapiens (human)	Kd	10.0000	1	2
Serine/threonine-protein kinase Nek2	Homo sapiens (human)	Kd	24.0000	3	10
Serine/threonine-protein kinase Nek3	Homo sapiens (human)	Kd	25.0000	2	8
Serine/threonine-protein kinase Nek4	Homo sapiens (human)	Kd	10.0000	1	2
Serine/threonine-protein kinase Nek5	Homo sapiens (human)	Kd	10.0000	2	3
Serine/threonine-protein kinase Nek6	Homo sapiens (human)	Kd	10.0000	2	3
Serine/threonine-protein kinase Nek7	Homo sapiens (human)	Kd	21.4286	3	7
Serine/threonine-protein kinase Nek9	Homo sapiens (human)	Kd	23.3333	3	9
Serine/threonine-protein kinase NIM1	Homo sapiens (human)	Kd	10.0000	1	2
Serine/threonine-protein kinase NLK	Homo sapiens (human)	Kd	22.2756	3	9
Serine/threonine-protein kinase OSR1	Homo sapiens (human)	Kd	10.0000	1	2
Serine/threonine-protein kinase PAK 1	Homo sapiens (human)	Kd	10.0000	2	3
Serine/threonine-protein kinase PAK 2	Homo sapiens (human)	Kd	22.5778	3	9
Serine/threonine-protein kinase PAK 3	Homo sapiens (human)	Kd	10.0000	2	3
Serine/threonine-protein kinase PAK 4	Homo sapiens (human)	Kd	22.3333	3	9
Serine/threonine-protein kinase PAK 5	Homo sapiens (human)	Kd	6.8400	2	3
Serine/threonine-protein kinase PAK 6	Homo sapiens (human)	Kd	18.5167	3	6
Serine/threonine-protein kinase pim-1	Homo sapiens (human)	EC50	5.0050	2	2
Serine/threonine-protein kinase pim-1	Homo sapiens (human)	Kd	23.1500	3	10
Serine/threonine-protein kinase pim-2	Homo sapiens (human)	EC50	5.0050	2	2
Serine/threonine-protein kinase pim-2	Homo sapiens (human)	Kd	16.0480	3	5
Serine/threonine-protein kinase pim-3	Homo sapiens (human)	EC50	5.0050	2	2
Serine/threonine-protein kinase pim-3	Homo sapiens (human)	Kd	7.6667	2	3
Serine/threonine-protein kinase PknB	Mycobacterium tuberculosis H37Rv	Kd	6.4500	1	2
Serine/threonine-protein kinase PLK1	Homo sapiens (human)	Kd	21.4286	3	7
Serine/threonine-protein kinase PLK2	Homo sapiens (human)	Kd	5.7000	1	2
Serine/threonine-protein kinase PLK3	Homo sapiens (human)	Kd	7.5000	2	3
Serine/threonine-protein kinase PLK4	Homo sapiens (human)	Kd	22.2300	3	9
Serine/threonine-protein kinase PRP4 homolog	Homo sapiens (human)	Kd	10.0000	1	2
Serine/threonine-protein kinase receptor R3	Homo sapiens (human)	Kd	12.5007	3	4
Serine/threonine-protein kinase RIO1	Homo sapiens (human)	Kd	10.0000	2	3
Serine/threonine-protein kinase RIO2	Homo sapiens (human)	Kd	4.9350	1	2
Serine/threonine-protein kinase RIO3	Homo sapiens (human)	Kd	10.0000	2	3
Serine/threonine-protein kinase SBK1	Homo sapiens (human)	Kd	10.0000	1	2
Serine/threonine-protein kinase Sgk3	Homo sapiens (human)	Kd	10.0000	1	2
Serine/threonine-protein kinase SIK1	Homo sapiens (human)	Kd	6.7733	2	3
Serine/threonine-protein kinase SIK2	Homo sapiens (human)	Kd	22.2800	3	9
Serine/threonine-protein kinase SIK3	Homo sapiens (human)	Kd	24.7667	2	9
Serine/threonine-protein kinase STK11	Homo sapiens (human)	Kd	22.5000	3	8
Serine/threonine-protein kinase TAO1	Homo sapiens (human)	Kd	23.7662	2	8
Serine/threonine-protein kinase TAO2	Homo sapiens (human)	Kd	23.7987	2	8
Serine/threonine-protein kinase TAO3	Homo sapiens (human)	Kd	23.8112	2	8
Serine/threonine-protein kinase TBK1	Homo sapiens (human)	Kd	25.5556	2	9
Serine/threonine-protein kinase TNNI3K	Homo sapiens (human)	Kd	6.9600	2	3
Serine/threonine-protein kinase tousled-like 1	Homo sapiens (human)	Kd	10.0000	2	3
Serine/threonine-protein kinase tousled-like 2	Homo sapiens (human)	Kd	10.0000	2	3
Serine/threonine-protein kinase ULK1	Homo sapiens (human)	Kd	25.0000	2	8
Serine/threonine-protein kinase ULK2	Homo sapiens (human)	Kd	7.4500	1	2
Serine/threonine-protein kinase ULK3	Homo sapiens (human)	Kd	25.5444	2	9
Serine/threonine-protein kinase VRK2	Homo sapiens (human)	Kd	10.0000	1	2
Serine/threonine-protein kinase/endoribonuclease IRE1	Homo sapiens (human)	Kd	25.0000	2	8
Serine/threonine-protein kinase/endoribonuclease IRE2	Homo sapiens (human)	Kd	30.0000	1	6
Signal recognition particle receptor subunit alpha	Homo sapiens (human)	Kd	30.0000	1	5
SNF-related serine/threonine-protein kinase	Homo sapiens (human)	Kd	10.0000	1	2
SRSF protein kinase 1	Homo sapiens (human)	Kd	10.0000	2	3
SRSF protein kinase 2	Homo sapiens (human)	Kd	10.0000	2	3
SRSF protein kinase 3	Homo sapiens (human)	Kd	10.0000	1	2
STE20-like serine/threonine-protein kinase	Homo sapiens (human)	Kd	22.2316	3	9
STE20-related kinase adapter protein alpha	Homo sapiens (human)	Kd	30.0000	1	6
STE20/SPS1-related proline-alanine-rich protein kinase	Homo sapiens (human)	Kd	10.0000	1	2
Structural maintenance of chromosomes protein 1A	Homo sapiens (human)	Kd	30.0000	1	6
Structural maintenance of chromosomes protein 2	Homo sapiens (human)	Kd	30.0000	1	6
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	7
Target of rapamycin complex subunit LST8	Homo sapiens (human)	EC50	0.0002	1	1
Testis-specific serine/threonine-protein kinase 1	Homo sapiens (human)	Kd	10.0000	2	3
TGF-beta receptor type-1	Homo sapiens (human)	Kd	22.2333	3	9
TGF-beta receptor type-2	Homo sapiens (human)	Kd	22.2500	3	9
Thyroid hormone receptor-associated protein 3	Homo sapiens (human)	Kd	30.0000	1	4
TRAF2 and NCK-interacting protein kinase	Homo sapiens (human)	Kd	22.2522	3	9
Transient receptor potential cation channel subfamily M member 6	Homo sapiens (human)	Kd	10.0000	1	2
Tubulin alpha-1A chain	Rattus norvegicus (Norway rat)	Kd	10.0000	1	1
Tyrosine--tRNA ligase, cytoplasmic	Homo sapiens (human)	Kd	30.0000	1	6
Tyrosine-protein kinase ABL1	Homo sapiens (human)	Kd	9.8527	23	43
Tyrosine-protein kinase ABL2	Homo sapiens (human)	Kd	22.3556	3	9
Tyrosine-protein kinase Blk	Homo sapiens (human)	Kd	6.7467	2	3
Tyrosine-protein kinase BTK	Homo sapiens (human)	Kd	22.5778	3	9
Tyrosine-protein kinase CSK	Homo sapiens (human)	Kd	23.2000	3	10
Tyrosine-protein kinase Fer	Homo sapiens (human)	Kd	23.3333	3	9
Tyrosine-protein kinase Fes/Fps	Homo sapiens (human)	Kd	23.3333	3	9
Tyrosine-protein kinase Fgr	Homo sapiens (human)	Kd	18.3600	3	6
Tyrosine-protein kinase FRK	Homo sapiens (human)	Kd	22.2856	3	9
Tyrosine-protein kinase Fyn	Homo sapiens (human)	Kd	23.0300	3	10
Tyrosine-protein kinase HCK	Homo sapiens (human)	Kd	22.2433	3	9
Tyrosine-protein kinase ITK/TSK	Homo sapiens (human)	Kd	10.0000	2	3
Tyrosine-protein kinase JAK1	Homo sapiens (human)	Kd	19.6667	4	12
Tyrosine-protein kinase JAK2	Homo sapiens (human)	Kd	12.5028	3	4
Tyrosine-protein kinase JAK3	Homo sapiens (human)	Kd	6.6953	2	3
Tyrosine-protein kinase Lck	Homo sapiens (human)	Kd	22.2444	3	9
Tyrosine-protein kinase Lyn	Homo sapiens (human)	Kd	23.0560	3	10
Tyrosine-protein kinase Mer	Homo sapiens (human)	Kd	13.6750	3	4
Tyrosine-protein kinase receptor Tie-1	Homo sapiens (human)	Kd	10.0000	2	3
Tyrosine-protein kinase receptor TYRO3	Homo sapiens (human)	Kd	10.0000	2	3
Tyrosine-protein kinase receptor UFO	Homo sapiens (human)	Kd	7.0667	2	3
Tyrosine-protein kinase Srms	Homo sapiens (human)	Kd	10.0000	2	3
Tyrosine-protein kinase SYK	Homo sapiens (human)	Kd	23.3333	3	9
Tyrosine-protein kinase Tec	Homo sapiens (human)	Kd	23.3333	3	9
Tyrosine-protein kinase TXK	Homo sapiens (human)	Kd	6.7767	2	3
Tyrosine-protein kinase Yes	Homo sapiens (human)	Kd	22.2400	3	9
Tyrosine-protein kinase ZAP-70	Homo sapiens (human)	Kd	10.0000	2	3
U5 small nuclear ribonucleoprotein 200 kDa helicase	Homo sapiens (human)	Kd	30.0000	1	6
UMP-CMP kinase	Homo sapiens (human)	Kd	30.0000	1	7
Uncharacterized aarF domain-containing protein kinase 5	Homo sapiens (human)	Kd	30.0000	1	4
Uncharacterized protein FLJ45252	Homo sapiens (human)	Kd	30.0000	1	6
Uncharacterized serine/threonine-protein kinase SBK3	Homo sapiens (human)	Kd	10.0000	1	2
Vascular endothelial growth factor receptor 1	Homo sapiens (human)	Kd	7.0667	2	3
Vascular endothelial growth factor receptor 2	Homo sapiens (human)	Kd	7.0667	2	3
Vascular endothelial growth factor receptor 3	Homo sapiens (human)	Kd	6.7467	2	3
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	8
Wee1-like protein kinase	Homo sapiens (human)	Kd	23.3333	3	9
Wee1-like protein kinase 2	Homo sapiens (human)	Kd	10.0000	1	2