A role played by a chemical agent which exhibits the capability of occupying space between DNA base pairs due to particular properties in size, shape and charge. Intercalation of chemical compounds in DNA helix can result in replication errors (shift, mutation) or DNA damages.
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 25.6651 | 1 | 2 |
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| 67.9K protein | Vaccinia virus | Potency | 9.3146 | 2 | 8 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 34.1947 | 3 | 6 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 14.4728 | 1 | 3 |
| alpha-galactosidase | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 14.1170 | 10 | 22 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 22.4240 | 2 | 6 |
| Ataxin-2 | Homo sapiens (human) | Potency | 20.1469 | 1 | 3 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 18.7094 | 2 | 4 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 23.1837 | 2 | 5 |
| caspase-1 isoform alpha precursor | Homo sapiens (human) | Potency | 4.8620 | 1 | 4 |
| Caspase-7 | Homo sapiens (human) | Potency | 3.9946 | 1 | 3 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 6.1071 | 3 | 7 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 3.0016 | 2 | 3 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 2.2247 | 1 | 3 |
| Chain A, ATP-DEPENDENT DNA HELICASE Q1 | Homo sapiens (human) | Potency | 28.4514 | 1 | 4 |
| Chain A, Breast cancer type 1 susceptibility protein | Homo sapiens (human) | Potency | 18.4029 | 2 | 4 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 25.1189 | 1 | 1 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 31.6228 | 1 | 1 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 64.7758 | 1 | 2 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 21.1789 | 2 | 5 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 1.3511 | 1 | 3 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 59.9574 | 1 | 3 |
| core-binding factor subunit beta isoform 2 | Homo sapiens (human) | Potency | 6.9603 | 3 | 5 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 1.5849 | 1 | 1 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 27.5404 | 1 | 1 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 3.4671 | 1 | 1 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 6.3096 | 1 | 1 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 14.3194 | 2 | 8 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 1.5487 | 1 | 1 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 19.1907 | 1 | 3 |
| Disintegrin and metalloproteinase domain-containing protein 17 | Homo sapiens (human) | Potency | 0.6310 | 1 | 1 |
| DNA polymerase eta isoform 1 | Homo sapiens (human) | Potency | 35.4668 | 2 | 6 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 14.3412 | 2 | 7 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 14.4126 | 2 | 14 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 28.1831 | 10 | 20 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 9.9008 | 1 | 2 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 5.3824 | 6 | 12 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 12.1508 | 1 | 4 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 8.9317 | 3 | 5 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 10.8395 | 2 | 5 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 4.4668 | 1 | 1 |
| G | Vesicular stomatitis virus | Potency | 27.5404 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 14.3194 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 14.3194 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 14.3194 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 14.3194 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 14.3194 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 14.3194 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 14.3194 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 14.3194 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 14.3194 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 14.3194 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 14.3194 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 14.3194 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 14.3194 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 14.3194 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 14.3194 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 14.3194 | 1 | 4 |
| geminin | Homo sapiens (human) | Potency | 13.6838 | 2 | 6 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 22.6716 | 2 | 4 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 3.7298 | 1 | 3 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 5.5035 | 3 | 5 |
| Glutamate receptor 1 | Rattus norvegicus (Norway rat) | Potency | 6.3096 | 1 | 1 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 18.2028 | 2 | 3 |
| Glutamate receptor 3 | Rattus norvegicus (Norway rat) | Potency | 6.3096 | 1 | 1 |
| Glutamate receptor 4 | Rattus norvegicus (Norway rat) | Potency | 6.3096 | 1 | 1 |
| GTP-binding nuclear protein Ran isoform 1 | Homo sapiens (human) | Potency | 0.2372 | 1 | 2 |
| Guanine nucleotide-binding protein G | Homo sapiens (human) | Potency | 29.5947 | 1 | 3 |
| heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | Homo sapiens (human) | Potency | 27.7170 | 1 | 2 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 25.0654 | 1 | 2 |
| hemoglobin subunit beta | Homo sapiens (human) | Potency | 2.5119 | 2 | 2 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 12.5893 | 1 | 3 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 19.4549 | 1 | 4 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 80.0112 | 2 | 2 |
| histone-lysine N-methyltransferase 2A isoform 2 precursor | Homo sapiens (human) | Potency | 41.1572 | 1 | 4 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 27.5404 | 1 | 1 |
| huntingtin isoform 2 | Homo sapiens (human) | Potency | 14.7755 | 1 | 4 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 26.0297 | 2 | 3 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| IDH1 | Homo sapiens (human) | Potency | 7.3551 | 1 | 3 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 0.2372 | 1 | 2 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 27.5404 | 1 | 2 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 19.7020 | 1 | 2 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 3.9811 | 1 | 1 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 3.9811 | 1 | 1 |
| Interferon beta | Homo sapiens (human) | Potency | 27.5404 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 17.5864 | 1 | 3 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 2.5119 | 1 | 1 |
| luciferase | Photuris pensylvanica (Pennsylania firefly) | Potency | 15.8489 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 5.3440 | 2 | 7 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 9.5325 | 3 | 4 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 5.0001 | 2 | 5 |
| nuclear factor NF-kappa-B p105 subunit isoform 1 | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 18.4675 | 1 | 2 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 16.7487 | 2 | 10 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 17.9584 | 2 | 4 |
| peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 75.6863 | 1 | 1 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 7.1313 | 2 | 4 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 40.0648 | 3 | 4 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 26.5881 | 2 | 3 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 40.9903 | 1 | 3 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 1.1904 | 1 | 2 |
| Platelet-activating factor receptor | Homo sapiens (human) | Potency | 29.8816 | 1 | 2 |
| polyprotein | Zika virus | Potency | 4.4668 | 1 | 1 |
| progesterone receptor | Homo sapiens (human) | Potency | 25.8539 | 1 | 2 |
| Rap guanine nucleotide exchange factor 3 | Homo sapiens (human) | Potency | 46.8078 | 2 | 4 |
| Rap guanine nucleotide exchange factor 4 | Homo sapiens (human) | Potency | 75.4550 | 2 | 4 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 23.3010 | 3 | 6 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 4.5186 | 3 | 3 |
| runt-related transcription factor 1 isoform AML1b | Homo sapiens (human) | Potency | 6.9603 | 3 | 5 |
| serine/threonine-protein kinase PLK1 | Homo sapiens (human) | Potency | 0.5030 | 1 | 2 |
| Smad3 | Homo sapiens (human) | Potency | 6.5655 | 1 | 4 |
| snurportin-1 | Homo sapiens (human) | Potency | 0.2372 | 1 | 2 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 10.0000 | 1 | 2 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 1.2177 | 2 | 14 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 25.7084 | 2 | 6 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 33.2482 | 4 | 10 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 31.1402 | 6 | 10 |
| transcriptional regulator ERG isoform 3 | Homo sapiens (human) | Potency | 30.3803 | 1 | 3 |
| tumor necrosis factor | Homo sapiens (human) | Potency | 37.5780 | 1 | 1 |
| tumor susceptibility gene 101 protein | Homo sapiens (human) | Potency | 10.0000 | 1 | 2 |
| ubiquitin carboxyl-terminal hydrolase 2 isoform a | Homo sapiens (human) | Potency | 0.6310 | 1 | 1 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 1.1904 | 1 | 2 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 1.1904 | 1 | 2 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 21.7984 | 2 | 6 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 21.7761 | 1 | 1 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 15.6968 | 1 | 2 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 30.7089 | 1 | 7 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 24.1495 | 1 | 2 |
| Vpr | Human immunodeficiency virus 1 | Potency | 9.0532 | 1 | 2 |
| WRN | Homo sapiens (human) | Potency | 13.3188 | 2 | 5 |