Compounds > buddlejasaponin iv
Page last updated: 2024-12-08

buddlejasaponin iv

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

buddlejasaponin IV: a triterpenoid saponin from the roots of Bupleurum rigidum; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
BupleurumgenusA plant genus of the family APIACEAE that is the source of bupleurum root and of bupleurotoxin and is an ingredient of sho-saiko-to.[MeSH]ApiaceaeA large plant family in the order Apiales, also known as Umbelliferae. Most are aromatic herbs with alternate, feather-divided leaves that are sheathed at the base. The flowers often form a conspicuous flat-topped umbel. Each small individual flower is usually bisexual, with five sepals, five petals, and an enlarged disk at the base of the style. The fruits are ridged and are composed of two parts that split open at maturity.[MeSH]

Cross-References

ID SourceID
PubMed CID153940
CHEMBL ID510087
MeSH IDM0376535

Synonyms (16)

Synonym
buddlejasaponin iv
CHEMBL510087
hz7j643r5f ,
139523-30-1
beta-d-galactopyranoside, (3beta,4alpha,16beta)-13,28-epoxy-16,23-dihydroxyolean-11-en-3-yl o-beta-d-glucopyranosyl-(1-2)-o-(beta-d-glucopyranosyl-(1-3))-6-deoxy-
unii-hz7j643r5f
saikosaponin 1
FS-9816
.beta.-d-galactopyranoside, (3.beta.,4.alpha.,16.beta.)-13,28-epoxy-16,23-dihydroxyolean-11-en-3-yl o-.beta.-d-glucopyranosyl-(1->2)-o-(.beta.-d-glucopyranosyl-(1->3))-6-deoxy-
(3.beta.,4.alpha.,16.beta.)-13,28-epoxy-16,23-dihydroxyolean-11-en-3-yl o-.beta.-d-glucopyranosyl-(1->2)-o-(.beta.-d-glucopyranosyl-(1->3))-6-deoxy-.beta.-d-galactopyranoside
buddleoglucoside iv
(2s,3r,4s,5s,6r)-2-[(2r,3r,4s,5s,6r)-5-hydroxy-2-[[(1s,2s,4s,5r,8r,9r,10s,13s,14r,17s,18r)-2-hydroxy-9-(hydroxymethyl)-4,5,9,13,20,20-hexamethyl-24-oxahexacyclo[15.5.2.01,18.04,17.05,14.08,13]tetracos-15-en-10-yl]oxy]-6-methyl-3-[(2s,3r,4s,5s,6r)-3,4,5-tr
DTXSID901315819
CS-0089422
HY-125131
AKOS040760309
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (20)

Assay IDTitleYearJournalArticle
AID332633Antiinflammatory activity in Swiss mouse assessed as inhibition of ethylphenylpropiolate-induced ear edema at 0.5 mg/ear administered tropically 16 hrs prior to ethylphenylpropiolate challenge1995Journal of natural products, Jan, Volume: 58, Issue:1
Anti-inflammatory activity of saikosaponins from Heteromorpha trifoliata.
AID427292Cytotoxicity against human A375 cells after 48 hrs by SRB assay2009Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13
Cytotoxic activity and inhibitory effect on nitric oxide production of triterpene saponins from the roots of Physospermum verticillatum (Waldst & Kit) (Apiaceae).
AID598192Cytotoxicity against PDGF-BB-induced rat VSMC at 50 uM2011Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11
A new iridoid and effect on the rat aortic vascular smooth muscle cell proliferation of isolated compounds from Buddleja officinalis.
AID427296Cytotoxicity against human A549 cells after 48 hrs by SRB assay2009Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13
Cytotoxic activity and inhibitory effect on nitric oxide production of triterpene saponins from the roots of Physospermum verticillatum (Waldst & Kit) (Apiaceae).
AID332636Antiinflammatory activity in Swiss mouse assessed as inhibition of serotonin-induced ear edema at 50 mg/kg, sc in presence of actinomycin D administered simultaneously and 1.5 hrs after compound treatment for 3 hrs1995Journal of natural products, Jan, Volume: 58, Issue:1
Anti-inflammatory activity of saikosaponins from Heteromorpha trifoliata.
AID427307Antioxidant activity assessed as DPPH radical scavenging activity by spectrophotometry2009Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13
Cytotoxic activity and inhibitory effect on nitric oxide production of triterpene saponins from the roots of Physospermum verticillatum (Waldst & Kit) (Apiaceae).
AID427298Cytotoxicity against human COR-L23 cells after 48 hrs by SRB assay2009Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13
Cytotoxic activity and inhibitory effect on nitric oxide production of triterpene saponins from the roots of Physospermum verticillatum (Waldst & Kit) (Apiaceae).
AID427300Cytotoxicity against human 142BR cells after 48 hrs by SRB assay2009Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13
Cytotoxic activity and inhibitory effect on nitric oxide production of triterpene saponins from the roots of Physospermum verticillatum (Waldst & Kit) (Apiaceae).
AID427297Cytotoxicity against human Huh-7D12 cells after 48 hrs by SRB assay2009Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13
Cytotoxic activity and inhibitory effect on nitric oxide production of triterpene saponins from the roots of Physospermum verticillatum (Waldst & Kit) (Apiaceae).
AID427306Cytotoxicity against mouse RAW264.7 cells by MTT assay2009Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13
Cytotoxic activity and inhibitory effect on nitric oxide production of triterpene saponins from the roots of Physospermum verticillatum (Waldst & Kit) (Apiaceae).
AID427291Cytotoxicity against human ACHN cells after 48 hrs by SRB assay2009Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13
Cytotoxic activity and inhibitory effect on nitric oxide production of triterpene saponins from the roots of Physospermum verticillatum (Waldst & Kit) (Apiaceae).
AID427293Cytotoxicity against human C32 cells after 48 hrs by SRB assay2009Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13
Cytotoxic activity and inhibitory effect on nitric oxide production of triterpene saponins from the roots of Physospermum verticillatum (Waldst & Kit) (Apiaceae).
AID332632Antiinflammatory activity in Swiss mouse assessed as inhibition of carrageenan-induced ear edema at 100 mg/kg, po administered 1 hr prior to carrageenan challenge measured after 3 hrs1995Journal of natural products, Jan, Volume: 58, Issue:1
Anti-inflammatory activity of saikosaponins from Heteromorpha trifoliata.
AID332637Antiinflammatory activity in Swiss mouse assessed as inhibition of serotonin-induced ear edema at 50 mg/kg, sc in presence of cycloheximide administered simultaneously and 1.5 hrs after compound treatment for 3 hrs1995Journal of natural products, Jan, Volume: 58, Issue:1
Anti-inflammatory activity of saikosaponins from Heteromorpha trifoliata.
AID427305Antiinflammatory activity in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of NO production after 24 hrs by Griess reagent method2009Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13
Cytotoxic activity and inhibitory effect on nitric oxide production of triterpene saponins from the roots of Physospermum verticillatum (Waldst & Kit) (Apiaceae).
AID427295Cytotoxicity against human LNCAP cells after 48 hrs by SRB assay2009Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13
Cytotoxic activity and inhibitory effect on nitric oxide production of triterpene saponins from the roots of Physospermum verticillatum (Waldst & Kit) (Apiaceae).
AID427299Cytotoxicity against human Caco-2 cells after 48 hrs by SRB assay2009Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13
Cytotoxic activity and inhibitory effect on nitric oxide production of triterpene saponins from the roots of Physospermum verticillatum (Waldst & Kit) (Apiaceae).
AID332631Antiinflammatory activity in Swiss mouse assessed as inhibition of 12-O-tetradecanoylphorbol acetate-induced ear edema at 0.5 mg/ear administered tropically1995Journal of natural products, Jan, Volume: 58, Issue:1
Anti-inflammatory activity of saikosaponins from Heteromorpha trifoliata.
AID427294Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay2009Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13
Cytotoxic activity and inhibitory effect on nitric oxide production of triterpene saponins from the roots of Physospermum verticillatum (Waldst & Kit) (Apiaceae).
AID332634Antiinflammatory activity in Swiss mouse assessed as inhibition of serotonin-induced ear edema at 50 mg/kg, sc1995Journal of natural products, Jan, Volume: 58, Issue:1
Anti-inflammatory activity of saikosaponins from Heteromorpha trifoliata.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's2 (22.22)18.2507
2000's3 (33.33)29.6817
2010's3 (33.33)24.3611
2020's1 (11.11)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.37

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.37 (24.57)
Research Supply Index2.30 (2.92)
Research Growth Index4.68 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.37)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
indomethacin
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.. indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.		2.4120aromatic ether;
indole-3-acetic acids;
monochlorobenzenes;
N-acylindole		analgesic;
drug metabolite;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
environmental contaminant;
gout suppressant;
non-steroidal anti-inflammatory drug;
xenobiotic metabolite;
xenobiotic
oleanolic acid
[no description available]		2.0510hydroxy monocarboxylic acid;
pentacyclic triterpenoid		plant metabolite
paclitaxel
Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).		2.0510taxane diterpenoid;
tetracyclic diterpenoid		antineoplastic agent;
human metabolite;
metabolite;
microtubule-stabilising agent
rhodioloside
[no description available]		2.0610glycoside
apigenin
Chamomile: Common name for several daisy-like plants (MATRICARIA; TRIPLEUROSPERMUM; ANTHEMIS; CHAMAEMELUM) native to Europe and Western Asia, now naturalized in the United States and Australia.		2.0610trihydroxyflavoneantineoplastic agent;
metabolite
acteoside
acteoside: a protein kinase C inhibitor with hepatoprotective, anti-asthmatic, and analgesic activities; a phenylethanoid glycoside related to isoacteoside; from leaves of Lippia multiflora (Verbenaceae). acteoside : A glycoside that is the alpha-L-rhamnosyl-(1->3)-beta-D-glucoside of hydroxytyrosol in which the hydroxy group at position 4 of the glucopyranosyl moiety has undergone esterification by formal condensation with trans-caffeic acid.		2.0610catechols;
cinnamate ester;
disaccharide derivative;
glycoside;
polyphenol		anti-inflammatory agent;
antibacterial agent;
antileishmanial agent;
neuroprotective agent;
plant metabolite
linarin
linarin: flavone glycoside isolated from leaves of Linaria japonica MIQ		2.0610
vinblastine sulfate
[no description available]		2.0510
beta-escin
[no description available]		3.4370
apigenin-7-o-rutinoside
[no description available]		2.0610
Phenylethyl beta-D-glucopyranoside
[no description available]		2.0610glycoside
ascorbic acid
Ascorbic Acid: A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.. L-ascorbic acid : The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate.. L-ascorbate : The L-enantiomer of ascorbate and conjugate base of L-ascorbic acid, arising from selective deprotonation of the 3-hydroxy group. Required for a range of essential metabolic reactions in all animals and plants.. vitamin C : Any member of a group of vitamers that belong to the chemical structural class called butenolides that exhibit biological activity against vitamin C deficiency in animals. The vitamers include L-ascorbic acid and its salt, ionized and oxidized forms.		2.0510ascorbic acid;
vitamin C		coenzyme;
cofactor;
flour treatment agent;
food antioxidant;
food colour retention agent;
geroprotector;
plant metabolite;
skin lightening agent
ConditionIndicatedRelationship StrengthStudiesTrials
Benign Neoplasms
[description not available]		02.0510
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		02.0510
Cancer of Mouth
[description not available]		02.5420
Mouth Neoplasms
Tumors or cancer of the MOUTH.		02.5420
Carcinoma, Epidermoid
[description not available]		02.0610
Carcinoma, Squamous Cell
A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)		02.0610
Anasarca
[description not available]		02.0310
Edema
Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.		02.0310