Roles > EC 2.7.1.1 (hexokinase) inhibitor
Page last updated: 2024-08-05 14:58:51

EC 2.7.1.1 (hexokinase) inhibitor

An EC 2.7.1.* (phosphotransferases with an alcohol group as acceptor) inhibitor that interferes with the action of hexokinase, EC 2.7.1.1, an enzyme that phosphorylates hexoses forming hexose phosphate.

ChEBI ID: 78366

Members (3)

MemberDefinitionClass
1,10-phenanthroline1,10-phenanthroline
ethylmaleimideA member of the class of maleimides that is the N-ethyl derivative of maleimide.N-ethylmaleimide
lonidamineA member of the class of indazoles that is 1H-indazole that is substituted at positions 1 and 3 by 2,4-dichlorobenzyl and carboxy groups, respectively.lonidamine

Research

Studies (7,888)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-19903,964 (50.25)18.7374
1990's1,956 (24.80)18.2507
2000's1,117 (14.16)29.6817
2010's742 (9.41)24.3611
2020's109 (1.38)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials60 (0.73%)5.53%
Reviews102 (1.25%)6.00%
Case Studies12 (0.15%)4.05%
Observational0 (0.00%)0.25%
Other8,000 (97.87%)84.16%

Protein Targets (149)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
15-lipoxygenase, partialHomo sapiens (human)Potency6.309611
67.9K proteinVaccinia virusPotency4.271624
acetylcholinesteraseHomo sapiens (human)Potency63.701824
activating transcription factor 6Homo sapiens (human)Potency38.638411
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency14.125411
Alpha-synucleinHomo sapiens (human)Potency29.092911
Amyloid-beta precursor proteinHomo sapiens (human)Potency18.356411
AR proteinHomo sapiens (human)Potency15.0102918
aryl hydrocarbon receptorHomo sapiens (human)Potency54.981722
arylsulfatase AHomo sapiens (human)Potency7.264112
ATAD5 protein, partialHomo sapiens (human)Potency5.192733
Ataxin-2Homo sapiens (human)Potency3.002022
ATP-dependent phosphofructokinaseTrypanosoma brucei brucei TREU927Potency23.730612
ATPase family AAA domain-containing protein 5Homo sapiens (human)Potency2.455911
Bloom syndrome protein isoform 1Homo sapiens (human)Potency177.828022
bromodomain adjacent to zinc finger domain 2BHomo sapiens (human)Potency1.584911
caspase-3Cricetulus griseus (Chinese hamster)Potency0.977711
Caspase-7Cricetulus griseus (Chinese hamster)Potency0.977711
Cellular tumor antigen p53Homo sapiens (human)Potency34.847936
cellular tumor antigen p53 isoform aHomo sapiens (human)Potency6.581222
Chain A, 2-oxoglutarate OxygenaseHomo sapiens (human)Potency17.866212
Chain A, Beta-lactamaseEscherichia coli K-12Potency2.055212
Chain A, JmjC domain-containing histone demethylation protein 3AHomo sapiens (human)Potency28.183811
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency12.659212
Chain A, Putative fructose-1,6-bisphosphate aldolaseGiardia intestinalisPotency14.299612
Chain A, TYROSYL-DNA PHOSPHODIESTERASEHomo sapiens (human)Potency45.732214
chromobox protein homolog 1Homo sapiens (human)Potency45.540223
core-binding factor subunit beta isoform 2Homo sapiens (human)Potency18.234333
cytochrome P450 2C9 precursorHomo sapiens (human)Potency39.810711
cytochrome P450 2D6 isoform 1Homo sapiens (human)Potency21.106913
cytochrome P450 3A4 isoform 1Homo sapiens (human)Potency3.761924
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency38.901811
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency7.928712
D(1A) dopamine receptorSus scrofa (pig)Potency0.046511
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency100.000011
endonuclease IVEscherichia coliPotency28.183811
estrogen nuclear receptor alphaHomo sapiens (human)Potency11.95661025
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency24.140325
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency20.27401023
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency25.421317
EWS/FLI fusion proteinHomo sapiens (human)Potency0.003711
farnesoid X nuclear receptorHomo sapiens (human)Potency12.437337
flap endonuclease 1Homo sapiens (human)Potency37.685811
Fumarate hydrataseHomo sapiens (human)Potency7.079511
GABA theta subunitRattus norvegicus (Norway rat)Potency3.761912
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)Potency3.761912
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)Potency3.761912
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)Potency3.761912
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)Potency3.761912
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)Potency3.761912
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)Potency3.761912
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)Potency3.761912
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)Potency3.761912
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)Potency3.761912
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)Potency3.761912
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)Potency3.761912
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)Potency3.761912
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)Potency3.761912
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)Potency3.761912
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)Potency3.761912
gemininHomo sapiens (human)Potency15.154034
GLI family zinc finger 3Homo sapiens (human)Potency13.687336
glp-1 receptor, partialHomo sapiens (human)Potency3.548111
GLS proteinHomo sapiens (human)Potency22.387211
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency18.946248
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency2.207613
heat shock protein beta-1Homo sapiens (human)Potency1.856724
Histamine H2 receptorCavia porcellus (domestic guinea pig)Potency39.810713
histone deacetylase 9 isoform 3Homo sapiens (human)Potency24.653124
Histone H2A.xCricetulus griseus (Chinese hamster)Potency8.407524
huntingtin isoform 2Homo sapiens (human)Potency10.000011
hypoxia-inducible factor 1 alpha subunitHomo sapiens (human)Potency27.658624
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)Homo sapiens (human)Potency12.791235
IDH1Homo sapiens (human)Potency7.307811
Integrin alpha-IIbHomo sapiens (human)Potency10.000011
Integrin beta-3Homo sapiens (human)Potency10.000011
lamin isoform A-delta10Homo sapiens (human)Potency13.596324
LuciferasePhotinus pyralis (common eastern firefly)Potency64.947223
M-phase phosphoprotein 8Homo sapiens (human)Potency84.279012
Microtubule-associated protein tauHomo sapiens (human)Potency22.938825
muscleblind-like protein 1 isoform 1Homo sapiens (human)Potency15.848911
neuropeptide S receptor isoform AHomo sapiens (human)Potency4.087112
NFKB1 protein, partialHomo sapiens (human)Potency5.011922
nonstructural protein 1Influenza A virus (A/WSN/1933(H1N1))Potency16.400114
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency25.392736
nuclear factor erythroid 2-related factor 2 isoform 2Homo sapiens (human)Potency11.082412
Nuclear receptor ROR-gammaHomo sapiens (human)Potency2.371011
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency20.904024
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency10.158035
ParkinHomo sapiens (human)Potency25.929011
peripheral myelin protein 22 isoform 1Homo sapiens (human)Potency49.124413
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency8.290238
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency5.987936
phosphopantetheinyl transferaseBacillus subtilisPotency7.943311
plasminogen precursorMus musculus (house mouse)Potency1.584911
polyproteinZika virusPotency7.079511
pregnane X nuclear receptorHomo sapiens (human)Potency22.737524
pregnane X receptorRattus norvegicus (Norway rat)Potency56.234111
progesterone receptorHomo sapiens (human)Potency4.013924
Rap guanine nucleotide exchange factor 4Homo sapiens (human)Potency6.309611
RAR-related orphan receptor gammaMus musculus (house mouse)Potency4.367824
regulator of G-protein signaling 4Homo sapiens (human)Potency3.996512
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency15.271737
retinoid X nuclear receptor alphaHomo sapiens (human)Potency15.4282410
runt-related transcription factor 1 isoform AML1bHomo sapiens (human)Potency18.234333
serine/threonine-protein kinase mTOR isoform 1Homo sapiens (human)Potency2.345822
SMAD family member 2Homo sapiens (human)Potency17.285323
SMAD family member 3Homo sapiens (human)Potency17.285323
Smad3Homo sapiens (human)Potency11.220211
survival motor neuron protein isoform dHomo sapiens (human)Potency6.777814
TAR DNA-binding protein 43Homo sapiens (human)Potency35.481311
TDP1 proteinHomo sapiens (human)Potency4.212025
thioredoxin reductaseRattus norvegicus (Norway rat)Potency5.534012
ThrombopoietinHomo sapiens (human)Potency2.048424
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency20.567926
thyroid hormone receptor beta isoform aHomo sapiens (human)Potency1.258911
thyroid stimulating hormone receptorHomo sapiens (human)Potency14.532527
tumor necrosis factorHomo sapiens (human)Potency33.491511
urokinase plasminogen activator surface receptor precursorMus musculus (house mouse)Potency1.584911
urokinase-type plasminogen activator precursorMus musculus (house mouse)Potency1.584911
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency15.851325
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency4.622235
vitamin D3 receptor isoform VDRAHomo sapiens (human)Potency44.668411
Voltage-dependent calcium channel gamma-2 subunitMus musculus (house mouse)Potency2.207613

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
14 kDa phosphohistidine phosphataseHomo sapiens (human)Ki209.000011
Beta-lactamase VIM-1 Pseudomonas aeruginosaIC5073.000011
C-C chemokine receptor type 1Homo sapiens (human)IC5076.716412
C-C chemokine receptor type 5Homo sapiens (human)IC5051.559312
Carboxypeptidase A1Bos taurus (cattle)IC50422.000011
Collagenase ColGHathewaya histolyticaIC50185.000011
exodeoxyribonuclease V subunit RecBEscherichia coli str. K-12 substr. MG1655IC5030.473011
exodeoxyribonuclease V subunit RecCEscherichia coli str. K-12 substr. MG1655IC5030.473011
exodeoxyribonuclease V subunit RecDEscherichia coli str. K-12 substr. MG1655IC5030.473011
Galanin receptor type 2Homo sapiens (human)IC5042.000022
Ghrelin O-acyltransferaseHomo sapiens (human)IC50433.000011
M17 leucyl aminopeptidasePlasmodium falciparum 3D7IC507.370011
Metallo-beta-lactamase VIM-13Pseudomonas aeruginosaIC5069.300011
Monoglyceride lipaseHomo sapiens (human)IC5016.600011
nonstructural protein 1Influenza A virus (A/California/07/2009(H1N1))IC500.902011
Protein farnesyltransferase subunit betaHomo sapiens (human)IC504,000.000011
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alphaHomo sapiens (human)IC504,000.000011
Snake venom metalloproteinase neuwiedaseBothrops pauloensisIC50470.000011
ThermolysinBacillus thermoproteolyticusIC50360.000011
TPA: protein transporter TIM10Saccharomyces cerevisiae S288CIC5012.300011
TPA: protein transporter TIM23Saccharomyces cerevisiae S288CIC509.590011

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
C-C chemokine receptor type 1Homo sapiens (human)EC506.104812
C-C chemokine receptor type 5Homo sapiens (human)EC504.955912
C-C chemokine receptor type 8Homo sapiens (human)EC503.940512
heat shock protein 90Candida albicansEC5010.463011

Other Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
heat shock protein 90, putativePlasmodium falciparum 3D7AC506.605011
heat shock protein HSP 90-alpha isoform 2Homo sapiens (human)AC507.106011