ascorbic-acid and Dermatitis

Topics: Acid-Base Equilibrium; Adaptation, Psychological; Ascorbic Acid; Dermatitis; Follow-Up Studies; Hemorrhage; Humans; Hydrogen-Ion Concentration; Ileum; Postoperative Care; Postoperative Complications; Surgical Wound Dehiscence; Surgical Wound Infection; Urinary Catheterization; Urinary Diversion

Topics: Administration, Topical; Antioxidants; Ascorbic Acid; Biopsy, Needle; Dermatitis; Environmental Exposure; Female; Humans; Immunohistochemistry; Male; Oxidative Stress; Ozone; Reference Values; Risk Assessment; Treatment Outcome

The inflammation which follows cryotherapy is a significant disadvantage of this therapeutic modality. To date, the only treatment shown to reduce this inflammation is application of topical corticoids. We have therefore conducted a pilot study to investigate whether pretreatment with the free radical scavengers, vitamins C and E might alleviate the signs and symptoms of inflammation following liquid nitrogen cryotherapy of common warts. We undertook a randomized, double-blind, placebo-controlled, parallel group study. We recruited 40 adult patients, of whom 38 returned for evaluation. Treatments comprised vitamin C (2000 mg) and vitamin E (800 IU) daily or matching placebo for 7 days prior to cryotherapy to a hand wart. Oedema volume, erythema level, pain intensity and the presence or absence of blistering were assessed 24 h after cryotherapy. There were no significant differences between the two treatment groups in any of the parameters assessed. This study yielded no suggestion of benefit from the use of pretreatment with free radical scavengers in conjunction with liquid nitrogen cryotherapy.

Topics: Adolescent; Adult; Aged; Ascorbic Acid; Blister; Cryotherapy; Dermatitis; Double-Blind Method; Edema; Erythema; Female; Humans; Male; Middle Aged; Pain, Postoperative; Pilot Projects; Vitamin E; Warts

Topics: Ascorbic Acid; Child; Child, Preschool; Clinical Trials as Topic; Dermatitis; Female; Hot Temperature; Humans; Infant; Male; Placebos

It is well known that ultraviolet B irradiation leads to dermal inflammation. In this study, we found that Mekabu fucoidan suppressed edema, decreased the thickness of the prickle cell layer, and decreased matrix metalloproteinase 1 in the skin of mice irradiated with ultraviolet B. Moreover, we found that the mean level of interferon gamma of Mekabu fucoidan-treated, ultraviolet B-irradiated mice (approximately 2.2 ng/mL) was not significantly different from that in normal mice (approximately 2.5 ng/mL). In contrast, a significant decrease in the mean level of interferon gamma (approximately 1.3 ng/mL) in ultraviolet B-irradiated control mice was observed compared with that in Mekabu fucoidan-treated, ultraviolet B-irradiated mice. The mean thickness of the prickle cell layer in the skin of Mekabu fucoidan-treated, ultraviolet B-irradiated mice was less than that in the ultraviolet B-irradiated control mice. Metalloproteinase 1 activity was significantly higher in the skin of ultraviolet B-irradiated mice than in the skin of untreated, nonirradiated normal mice. Metalloproteinase 1 in the skin of ultraviolet B-irradiated, Mekabu fucoidan- or L(+)-ascorbic acid (vitamin C)-treated mice was significantly lower than that in the ultraviolet B-irradiated control mice. Mitigation of the morphological changes in Mekabu fucoidan-treated mice was correlated with a decrease in metalloproteinase 1 levels. These data indicate that Mekabu fucoidan is an effective suppressor of inflammation in an ultraviolet B-irradiated mouse model.

Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Ascorbic Acid; Dermatitis; Diet; Immunity; Immunosuppression Therapy; Matrix Metalloproteinase 13; Mice; Polysaccharides; Skin; Ultraviolet Rays; Undaria

Oral administration of specific food ingredients can modify mucosal and systemic inflammatory processes. Such food components are fatty acids or carbohydrates. Nevertheless, little is known about the impact of oral administration of polyunsaturated fatty acids (PUFA) and non-digestible oligosaccharides on allergen-induced dermatitis.. In this pilot study, skin inflammation was induced by serial epicutaneous OVA applications in OVA-sensitized mice. In parallel, mice were fed with solid food containing arachidonic acid/docosahexaenoic acid (AA/DHA), galactooligosaccharide/polydextrose (GOS/PDX) or their combination. Skin lesions were assessed by clinical skin score, but also skin barrier parameters, immunohistochemical analyses, and local cytokine expression profile.. Both dietary AA/DHA and GOS/PDX significantly ameliorated the severity of allergen-induced dermatitis. The clinical improvement upon oral AA/DHA and GOS/PDX supplementation was associated with a reduction in transepidermal water loss and reduced KI-67 expression in the skin. Lesional CD8+ and mast cells were reduced in all treatment groups, but appeared to be most pronounced in combined AA/DHA/GOS/PDX-treated mice. Moreover, in GOS/PDX-treated mice, IFNγ and TGFβ expression was increased in skin lesions.. Dietary supplementation with DHA/AA and GOS/PDX ameliorates symptoms of allergen-induced dermatitis and may thus be beneficial in the dietary management of human atopic eczema.

Topics: Allergens; Animals; Ascorbic Acid; CD8-Positive T-Lymphocytes; Cytokines; Dermatitis; Diet; Disease Progression; Docosahexaenoic Acids; Fatty Acids, Unsaturated; Feeding Behavior; Female; Glucans; Humans; Mast Cells; Mice; Mice, Inbred BALB C; Ovalbumin; Pilot Projects; Skin

The clinicopathological findings of perforating dermatitis in two young and two adult cats are described. In all cases, the lesions were characterized by single or multiple papules and plaques, 0.5-3.0 cm in diameter, each containing a central, firm, exophytic, cone-shaped, yellow-orange keratotic plug, tightly adherent to the underlying skin. Removal of the protruding material was associated with bleeding and left the ulcerated surface exposed. In one case, the lesions showed a linear configuration and identical lesions occurred on the suture sites following biopsy. Histopathologically, the diagnosis was straightforward because of the presence of vertically orientated collagen bundles extruded from ulcerated, concave-shaped invaginations of the skin. In two cases, vitamin C administration failed to resolve the disease. In two cases, methyl-prednisolone acetate was used to manage relapsing episodes and vitamin C helped to reduce glucocorticoid requirements. In one case, treatment with methyl-prednisolone acetate only appeared to be curative. The fourth case was lost to follow-up immediately after the diagnosis.

Topics: Animals; Anti-Inflammatory Agents; Ascorbic Acid; Cat Diseases; Cats; Dermatitis; Female; Male; Methylprednisolone; Methylprednisolone Acetate

Topics: Adolescent; Ascorbic Acid; Cytochrome c Group; Dermatitis; Drug Therapy, Combination; Glutathione; Humans; Middle Aged; Radiation Injuries; Urokinase-Type Plasminogen Activator

Topics: Ascorbic Acid; Chromates; Dermatitis; Dermatitis, Contact; Dermatitis, Occupational; Eczema; Edetic Acid; Female; Humans; Ion Exchange; Male; Ointments; Skin Tests; Switzerland

Topics: Aerosols; Animals; Antidotes; Ascorbic Acid; Chelating Agents; Chromates; Dermatitis; Dermatitis, Occupational; Filtration; Guinea Pigs; Humans; Male; Oxidation-Reduction; Rats; Skin Ulcer; Ventilators, Mechanical

Topics: Adult; Ascorbic Acid; Calcium; Dermatitis; Female; Humans; Light; Male; Middle Aged; Niacinamide; Porphyrias; Potassium; Prurigo; Riboflavin; Vitamins

Topics: Acne Vulgaris; Adolescent; Amino Acids; Ascorbic Acid; Dermatitis; Dermatitis, Contact; Dermatology; Drug Eruptions; Eczema; Erythema; Glutamates; Melanosis; Neurodermatitis; Pantothenic Acid; Polyarteritis Nodosa; Psoriasis; Tablets; Tiopronin; Toxicology; Urticaria

Topics: Ascorbic Acid; Dermatitis; Flavonoids; Humans; Vitamins

Topics: Aniline Compounds; Ascorbic Acid; Chromium; Coloring Agents; Dermatitis; Dermatitis, Contact; Humans; Turpentine; Vitamins

Topics: Acne Vulgaris; Ascorbic Acid; Dermatitis; Dermatitis, Contact; Humans; Oils; Sebaceous Gland Diseases; Vitamin A; Vitamins

Topics: Ascorbic Acid; Biomedical Research; Dermatitis; Dermatitis, Contact; Humans; Rhus; Toxicodendron