Roles > gamma-secretase modulator
Page last updated: 2024-08-05 15:44:17

gamma-secretase modulator

A modulator of gamma-secretase, one of the three endopeptidases that are specific for amyloid protein precursor and which have been identified based upon the region of the amyloid protein precursor which they cleave.

ChEBI ID: 48668

Members (1)

MemberDefinitionClass
auraptenA member of the class of coumarins that is umbelliferone in which the phenolic hydrogen has been replaced by a geranyl group. Ii is isolated from several edible fruits and vegetables and exhibits a variety of therapeutic properties.auraptene

Research

Studies (169)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-19901 (0.59)18.7374
1990's6 (3.55)18.2507
2000's37 (21.89)29.6817
2010's87 (51.48)24.3611
2020's38 (22.49)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials1 (0.58%)5.53%
Reviews13 (7.56%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other158 (91.86%)84.16%

Protein Targets (102)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1Homo sapiens (human)Potency33.552012
acid sphingomyelinaseHomo sapiens (human)Potency31.622811
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency32.059413
alpha-galactosidaseHomo sapiens (human)Potency14.125411
apical membrane antigen 1, AMA1Plasmodium falciparum 3D7Potency15.848911
bromodomain adjacent to zinc finger domain 2BHomo sapiens (human)Potency56.234111
Chain A, 2-oxoglutarate OxygenaseHomo sapiens (human)Potency31.832612
Chain A, HADH2 proteinHomo sapiens (human)Potency31.622811
Chain A, JmjC domain-containing histone demethylation protein 3AHomo sapiens (human)Potency56.234112
Chain A, TYROSYL-DNA PHOSPHODIESTERASEHomo sapiens (human)Potency40.397312
Chain B, HADH2 proteinHomo sapiens (human)Potency31.622811
chromobox protein homolog 1Homo sapiens (human)Potency56.234111
cytochrome P450 3A4 isoform 1Homo sapiens (human)Potency39.810722
DNA polymerase eta isoform 1Homo sapiens (human)Potency89.125111
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency22.387211
GABA theta subunitRattus norvegicus (Norway rat)Potency39.810711
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)Potency39.810711
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)Potency39.810711
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)Potency39.810711
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)Potency39.810711
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)Potency39.810711
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)Potency39.810711
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)Potency39.810711
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)Potency39.810711
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)Potency39.810711
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)Potency39.810711
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)Potency39.810711
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)Potency39.810711
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)Potency39.810711
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)Potency39.810711
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)Potency39.810711
gemininHomo sapiens (human)Potency11.582111
glp-1 receptor, partialHomo sapiens (human)Potency19.952611
glucocerebrosidaseHomo sapiens (human)Potency31.622811
lethal(3)malignant brain tumor-like protein 1 isoform IHomo sapiens (human)Potency31.622811
LuciferasePhotinus pyralis (common eastern firefly)Potency37.933011
Microtubule-associated protein tauHomo sapiens (human)Potency12.589311
mitogen-activated protein kinase 1Homo sapiens (human)Potency39.810711
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency7.079511
parathyroid hormone/parathyroid hormone-related peptide receptor precursorHomo sapiens (human)Potency79.432811
ParkinHomo sapiens (human)Potency44.668411
PINK1Homo sapiens (human)Potency44.668411
serine-protein kinase ATM isoform aHomo sapiens (human)Potency22.387211
Smad3Homo sapiens (human)Potency35.481311
TAR DNA-binding protein 43Homo sapiens (human)Potency10.000011
TDP1 proteinHomo sapiens (human)Potency23.724622
USP1 protein, partialHomo sapiens (human)Potency56.234111

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Acyl carrier protein, mitochondrialHomo sapiens (human)IC5014.500022
Amine oxidase [flavin-containing] AMus musculus (house mouse)IC500.000011
Amine oxidase [flavin-containing] BMus musculus (house mouse)IC500.300022
Beta-secretase 1Homo sapiens (human)IC50345.100011
Complex I intermediate-associated protein 30, mitochondrialHomo sapiens (human)IC5014.500022
Cytochrome c oxidase subunit NDUFA4Homo sapiens (human)IC5014.500022
Melatonin receptor type 1AHomo sapiens (human)Ki1.900011
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2Homo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3Homo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4Homo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1Homo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrialHomo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11Homo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12Homo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13Homo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 Homo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3Homo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2Homo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5Homo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6Homo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7Homo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8Homo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrialHomo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1Homo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10Homo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrialHomo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrialHomo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3Homo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 Homo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrialHomo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6Homo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7Homo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrialHomo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9Homo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrialHomo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] 1 subunit C2Homo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrialHomo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrialHomo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrialHomo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrialHomo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrialHomo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrialHomo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] iron-sulfur protein 5Homo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrialHomo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrialHomo sapiens (human)IC5014.500022
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrialHomo sapiens (human)IC5014.500022
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrialHomo sapiens (human)IC5014.500022
NADH-ubiquinone oxidoreductase chain 1Homo sapiens (human)IC5014.500022
NADH-ubiquinone oxidoreductase chain 2Homo sapiens (human)IC5014.500022
NADH-ubiquinone oxidoreductase chain 3Homo sapiens (human)IC5014.500022
NADH-ubiquinone oxidoreductase chain 4Homo sapiens (human)IC5014.500022
NADH-ubiquinone oxidoreductase chain 4LHomo sapiens (human)IC5014.500022
NADH-ubiquinone oxidoreductase chain 5Homo sapiens (human)IC5014.500022
NADH-ubiquinone oxidoreductase chain 6Homo sapiens (human)IC5014.500022
Polyunsaturated fatty acid lipoxygenase ALOX15Homo sapiens (human)IC5023.900011