Any drug which binds to vasopressin receptors and triggers a response.
ChEBI ID: 59727
| Member | Definition | Class |
|---|---|---|
| deamino arginine vasopressin | A synthetic analogue of vasopressin in which 3-mercaptopropionic acid replaces the cysteine residue at position 1 and D-arginine replaces the residue at position 8. An antidiuretic, it increases urine concentration and decreases urine production, and is used (usually as the trihydrate of the acetic acid salt) to prevent and control excessive thirst, urination, and dehydration caused by injury, surgery, and certain medical conditions. It is also used in the diagnosis and treatment of cranial diabetes insipidus and in tests of renal function. | desmopressin |
| felypressin | A synthetic nonapeptide comprising cysteinyl, phenylalanyl, phenylalanyl, glutaminyl, asparaginyl, cysteinyl, prolyl, lysyl, and glycinamide residues in sequence, with a disulfide bridge joining the two cysteine residues. Its antidiuretic effects are less than those of vasopressin. It is used as a vasoconstrictor in local anaesthetic injections for dental use, and is an ingredient of preparations that have been used for treatment of pain and inflammation of the mouth. | felypressin |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 1,054 (24.08) | 18.7374 |
| 1990's | 1,144 (26.14) | 18.2507 |
| 2000's | 1,046 (23.90) | 29.6817 |
| 2010's | 865 (19.76) | 24.3611 |
| 2020's | 268 (6.12) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 546 (11.84%) | 5.53% |
| Reviews | 697 (15.11%) | 6.00% |
| Case Studies | 849 (18.41%) | 4.05% |
| Observational | 17 (0.37%) | 0.25% |
| Other | 2,503 (54.27%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Translocator protein | Mus musculus (house mouse) | Ki | 0.0003 | 1 | 2 |
| Vasopressin V1a receptor | Homo sapiens (human) | Ki | 0.0624 | 1 | 1 |
| Vasopressin V1b receptor | Homo sapiens (human) | Ki | 0.0058 | 1 | 1 |
| Vasopressin V2 receptor | Homo sapiens (human) | Ki | 0.0233 | 1 | 1 |
| Vasopressin V2 receptor | Rattus norvegicus (Norway rat) | Ki | 0.0003 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Oxytocin receptor | Homo sapiens (human) | EC50 | 0.0910 | 2 | 2 |
| Vasopressin V1a receptor | Homo sapiens (human) | EC50 | 1.0000 | 1 | 1 |
| Vasopressin V1b receptor | Homo sapiens (human) | EC50 | 0.0110 | 2 | 2 |
| Vasopressin V2 receptor | Homo sapiens (human) | EC50 | 0.0002 | 2 | 2 |
| Vasopressin V2 receptor | Rattus norvegicus (Norway rat) | EC50 | 0.0000 | 1 | 1 |