Any EC 3.1.1.* (carboxylic ester hydrolase) inhibitor that inhibits the action of triacylglycerol lipase (EC 3.1.1.3).
ChEBI ID: 65001
| Member | Definition | Class |
|---|---|---|
| 7-phloroeckol | A phlorotannin that is eckol in which the hydroxy group at position 7 is replaced by a 2,4,6-trihydroxyphenoxy group. Isolated from the marine brown alga, Ecklonia cava, it exhibits antioxidant activity. | 7-phloroeckol |
| benzaldehyde | An arenecarbaldehyde that consists of benzene bearing a single formyl substituent; the simplest aromatic aldehyde and parent of the class of benzaldehydes. | benzaldehyde |
| benzoic acid | A compound comprising a benzene ring core carrying a carboxylic acid substituent. | benzoic acid |
| galangin | A 7-hydroxyflavonol with additional hydroxy groups at positions 3 and 5 respectively; a growth inhibitor of breast tumor cells. | galangin |
| orlistat | A carboxylic ester resulting from the formal condensation of the carboxy group of N-formyl-L-leucine with the hydroxy group of (3S,4S)-3-hexyl-4-[(2S)-2-hydroxytridecyl]oxetan-2-one. A pancreatic lipase inhibitor, it is used as an anti-obesity drug. | orlistat |
| sodium benzoate | An organic sodium salt resulting from the replacement of the proton from the carboxy group of benzoic acid by a sodium ion. | sodium benzoate |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 673 (12.87) | 18.7374 |
| 1990's | 681 (13.03) | 18.2507 |
| 2000's | 1,560 (29.84) | 29.6817 |
| 2010's | 1,717 (32.84) | 24.3611 |
| 2020's | 597 (11.42) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 346 (6.25%) | 5.53% |
| Reviews | 445 (8.04%) | 6.00% |
| Case Studies | 182 (3.29%) | 4.05% |
| Observational | 1 (0.02%) | 0.25% |
| Other | 4,559 (82.40%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| acetylcholinesterase | Homo sapiens (human) | Potency | 2.8621 | 3 | 4 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 3.3780 | 1 | 1 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 3.1623 | 1 | 1 |
| apical membrane antigen 1, AMA1 | Plasmodium falciparum 3D7 | Potency | 12.5893 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 5.0544 | 3 | 3 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 12.9900 | 1 | 1 |
| BRCA1 | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 8.4447 | 1 | 3 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 50.1187 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 3.9811 | 1 | 1 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 3.1623 | 1 | 1 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 2.7540 | 1 | 1 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 15.8489 | 2 | 2 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 1.9497 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 89.1251 | 1 | 2 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 7.5193 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 28.9966 | 6 | 6 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 25.5224 | 3 | 3 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 37.0574 | 4 | 4 |
| G | Vesicular stomatitis virus | Potency | 2.7540 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| geminin | Homo sapiens (human) | Potency | 16.9711 | 2 | 2 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 0.6419 | 1 | 1 |
| GLS protein | Homo sapiens (human) | Potency | 12.5893 | 1 | 2 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 0.3011 | 1 | 1 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 9.4384 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 3.1623 | 1 | 3 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 39.0762 | 1 | 1 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 2.7540 | 1 | 1 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 2.7540 | 1 | 2 |
| Interferon beta | Homo sapiens (human) | Potency | 2.7540 | 1 | 1 |
| interleukin 8 | Homo sapiens (human) | Potency | 74.9780 | 1 | 1 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 1.2589 | 1 | 1 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 93.8968 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 16.8037 | 1 | 2 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 13.3322 | 1 | 1 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 4.7618 | 1 | 2 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 39.9920 | 2 | 2 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 11.8823 | 1 | 1 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| progesterone receptor | Homo sapiens (human) | Potency | 1.8834 | 1 | 1 |
| Rap guanine nucleotide exchange factor 3 | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 18.3676 | 2 | 2 |
| Smad3 | Homo sapiens (human) | Potency | 20.5523 | 1 | 2 |
| TDP1 protein | Homo sapiens (human) | Potency | 19.6859 | 2 | 7 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 24.9565 | 1 | 1 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 10.0000 | 2 | 2 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 56.2341 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 3-oxoacyl-acyl-carrier protein reductase | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 100.0000 | 1 | 1 |
| Acetylcholinesterase | Homo sapiens (human) | Ki | 85.6000 | 1 | 1 |
| Acyl-protein thioesterase 2 | Rattus norvegicus (Norway rat) | IC50 | 0.1700 | 1 | 1 |
| Adenosine receptor A2a | Homo sapiens (human) | Ki | 22.6000 | 3 | 3 |
| Adenosine receptor A3 | Homo sapiens (human) | Ki | 3.1500 | 2 | 2 |
| Alpha-glucosidase MAL12 | Saccharomyces cerevisiae S288C | IC50 | 300.0000 | 1 | 1 |
| Amine oxidase [flavin-containing] A | Homo sapiens (human) | IC50 | 0.1300 | 1 | 1 |
| Amine oxidase [flavin-containing] B | Homo sapiens (human) | IC50 | 3.6500 | 1 | 1 |
| Amyloid-beta precursor protein | Homo sapiens (human) | IC50 | 500.0000 | 2 | 2 |
| Aromatase | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Aurora kinase B | Homo sapiens (human) | IC50 | 9.8000 | 1 | 1 |
| Beta-lactamase | Klebsiella pneumoniae | IC50 | 2,000.0000 | 1 | 1 |
| Beta-secretase 1 | Homo sapiens (human) | IC50 | 8.5900 | 1 | 1 |
| Beta-secretase 1 | Homo sapiens (human) | Ki | 7.2000 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Botulinum neurotoxin type A | Clostridium botulinum | IC50 | 2.9000 | 1 | 1 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Cannabinoid receptor 1 | Homo sapiens (human) | IC50 | 0.1000 | 1 | 1 |
| Cannabinoid receptor 1 | Homo sapiens (human) | Ki | 2.5000 | 1 | 1 |
| Cannabinoid receptor 2 | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| Carbonic anhydrase | Candida albicans SC5314 | Ki | 24.4000 | 1 | 1 |
| Carbonic anhydrase 1 | Homo sapiens (human) | Ki | 370.0000 | 2 | 2 |
| Carbonic anhydrase 12 | Homo sapiens (human) | Ki | 0.0418 | 1 | 1 |
| Carbonic anhydrase 2 | Homo sapiens (human) | Ki | 23.3333 | 3 | 3 |
| Carbonic anhydrase 4 | Homo sapiens (human) | Ki | 37.6342 | 2 | 2 |
| Carbonic anhydrase 5A, mitochondrial | Homo sapiens (human) | Ki | 7,010.0000 | 1 | 1 |
| Carbonic anhydrase 7 | Homo sapiens (human) | Ki | 0.0245 | 1 | 1 |
| Carbonic anhydrase 9 | Homo sapiens (human) | Ki | 150,000.0000 | 1 | 1 |
| Chain A, Oxygen-insensitive Nad(p)h Nitroreductase | Enterobacter cloacae | Ki | 100.0000 | 1 | 1 |
| Chain B, Oxygen-insensitive Nad(p)h Nitroreductase | Enterobacter cloacae | Ki | 100.0000 | 1 | 1 |
| Chain B, SARS CORONAVIRUS MAIN PROTEINASE | Severe acute respiratory syndrome-related coronavirus | IC50 | 5.0000 | 1 | 1 |
| Cytochrome P450 1A1 | Homo sapiens (human) | IC50 | 0.0770 | 1 | 1 |
| Cytochrome P450 1A2 | Homo sapiens (human) | IC50 | 0.0400 | 1 | 1 |
| Cytochrome P450 1B1 | Homo sapiens (human) | IC50 | 0.0140 | 2 | 2 |
| Cytochrome P450 2A5 | Mus musculus (house mouse) | IC50 | 3.2800 | 1 | 1 |
| Cytochrome P450 2A6 | Homo sapiens (human) | IC50 | 3.9200 | 1 | 1 |
| Cytochrome P450 2C19 | Homo sapiens (human) | IC50 | 0.4200 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 0.4200 | 1 | 1 |
| D-amino-acid oxidase | Homo sapiens (human) | IC50 | 62.1723 | 4 | 4 |
| D-amino-acid oxidase | Homo sapiens (human) | Ki | 22.2800 | 5 | 5 |
| D-aspartate oxidase | Homo sapiens (human) | IC50 | 10,000.0000 | 2 | 2 |
| Diacylglycerol lipase-alpha | Homo sapiens (human) | IC50 | 0.2678 | 4 | 4 |
| Diacylglycerol lipase-alpha | Mus musculus (house mouse) | IC50 | 0.0200 | 1 | 1 |
| Diacylglycerol lipase-beta | Homo sapiens (human) | IC50 | 0.2400 | 2 | 2 |
| Dihydroorotate dehydrogenase | Leishmania major | IC50 | 490.8935 | 1 | 2 |
| Dipeptidyl peptidase 3 | Homo sapiens (human) | IC50 | 23.4000 | 1 | 1 |
| Endothelial lipase | Homo sapiens (human) | IC50 | 0.0060 | 1 | 1 |
| Fatty acid synthase | Homo sapiens (human) | IC50 | 69.6600 | 3 | 3 |
| Fatty acid synthase | Homo sapiens (human) | Ki | 0.2800 | 1 | 1 |
| Fatty-acid amide hydrolase 1 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Fatty-acid amide hydrolase 1 | Rattus norvegicus (Norway rat) | IC50 | 0.0100 | 1 | 1 |
| Hepatic triacylglycerol lipase | Homo sapiens (human) | IC50 | 0.0030 | 1 | 1 |
| Histone-lysine N-methyltransferase SETD7 | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| Kappa-type opioid receptor | Mus musculus (house mouse) | IC50 | 0.1903 | 1 | 2 |
| Lipoprotein lipase | Homo sapiens (human) | IC50 | 0.0660 | 1 | 1 |
| Lysophosphatidylserine lipase ABHD12 | Homo sapiens (human) | IC50 | 0.1682 | 3 | 5 |
| Monoacylglycerol lipase ABHD6 | Homo sapiens (human) | IC50 | 0.0300 | 5 | 6 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Ki | 54.0000 | 1 | 1 |
| Neuronal acetylcholine receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Ki | 54.0000 | 1 | 1 |
| Neutral cholesterol ester hydrolase 1 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Nicotinate phosphoribosyltransferase | Homo sapiens (human) | Ki | 0.0019 | 1 | 1 |
| Pancreatic triacylglycerol lipase | Homo sapiens (human) | IC50 | 0.3253 | 3 | 3 |
| Pancreatic triacylglycerol lipase | Sus scrofa (pig) | IC50 | 0.4214 | 14 | 14 |
| Pancreatic triacylglycerol lipase | Sus scrofa (pig) | Ki | 5.0300 | 2 | 2 |
| Peroxisome proliferator-activated receptor gamma | Homo sapiens (human) | Ki | 5.6000 | 1 | 1 |
| Phosphatidylserine lipase ABHD16A | Homo sapiens (human) | IC50 | 0.1000 | 2 | 2 |
| Platelet-activating factor acetylhydrolase | Homo sapiens (human) | IC50 | 0.0500 | 1 | 1 |
| Polyphenol oxidase 2 | Agaricus bisporus | IC50 | 343.3729 | 6 | 7 |
| Proteasome subunit beta type-1 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Proteasome subunit beta type-2 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Proteasome subunit beta type-5 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Protein disulfide-isomerase | Homo sapiens (human) | Ki | 5.9000 | 1 | 1 |
| Receptor-type tyrosine-protein kinase FLT3 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | IC50 | 77.0500 | 2 | 2 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | Ki | 19.3000 | 1 | 1 |
| Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | Oryctolagus cuniculus (rabbit) | IC50 | 9.0000 | 1 | 1 |
| Serine racemase | Homo sapiens (human) | IC50 | 10,000.0000 | 1 | 1 |
| Short transient receptor potential channel 5 | Homo sapiens (human) | IC50 | 0.4500 | 1 | 1 |
| Solute carrier family 22 member 20 | Mus musculus (house mouse) | Ki | 13.8019 | 1 | 2 |
| Solute carrier family 22 member 6 | Mus musculus (house mouse) | Ki | 252.0945 | 1 | 2 |
| TPA: protein transporter TIM10 | Saccharomyces cerevisiae S288C | IC50 | 67.7500 | 2 | 2 |
| TPA: protein transporter TIM23 | Saccharomyces cerevisiae S288C | IC50 | 8.5600 | 1 | 1 |
| Translocator protein | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 1 |
| Tyrosinase | Homo sapiens (human) | IC50 | 820.0000 | 1 | 1 |
| Tyrosinase | Homo sapiens (human) | Ki | 520.0000 | 1 | 1 |
| Xanthine dehydrogenase/oxidase | Homo sapiens (human) | IC50 | 1.8000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | Kd | 5.8884 | 1 | 1 |
| ATP-dependent translocase ABCB1 | Mus musculus (house mouse) | Kd | 5.9000 | 1 | 1 |
| Beta-lactamase | Klebsiella pneumoniae | Kd | 1,000.0000 | 1 | 1 |
| D-amino-acid oxidase | Homo sapiens (human) | Kd | 4.5000 | 3 | 3 |
| D-amino-acid oxidase | Sus scrofa (pig) | Kd | 2.3000 | 1 | 1 |
| Metabotropic glutamate receptor 5 | Homo sapiens (human) | EC50 | 10.0000 | 1 | 1 |
| Nuclear receptor subfamily 1 group I member 2 | Homo sapiens (human) | EC50 | 14.9000 | 2 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Androgen receptor | Homo sapiens (human) | EC150 | 633.0000 | 1 | 1 |
| Glucocorticoid receptor | Homo sapiens (human) | EC150 | 633.0000 | 1 | 1 |
| Monocarboxylate transporter 1 | Rattus norvegicus (Norway rat) | Km | 3.0500 | 1 | 1 |
| Pancreatic triacylglycerol lipase | Sus scrofa (pig) | Km | 225.8400 | 3 | 3 |