Compounds > n'-(10h-indolo(3,2-b)quinolin-11-yl)-n,n-dimethylpropane-1,3-diamine
Page last updated: 2024-11-12

n'-(10h-indolo(3,2-b)quinolin-11-yl)-n,n-dimethylpropane-1,3-diamine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID10567578
CHEMBL ID219728
SCHEMBL ID16986957
MeSH IDM0511397

Synonyms (12)

Synonym
CHEMBL219728 ,
bdbm50176906
n-(3-(dimethylamino)propyl)-10h-indolo[3,2-b]quinolin-11-amine
n1-(10h-indolo[3,2-b]quinolin-11-yl)-n3,n3-dimethylpropane-1,3-diamine
n''-(10h-indolo[3,2-b]quinolin-11-yl)-n,n-dimethylpropane-1,3-diamine
syuiq-5
188630-47-9
DTXSID50441888
n-(10h-indolo[3,2-b]quinolin-11-yl)-n',n'-dimethylpropane-1,3-diamine
SCHEMBL16986957
syuiq-5, >=98% (hplc)
NCGC00487123-01

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
"The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs."( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019)		0.51
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Telomerase reverse transcriptaseHomo sapiens (human)IC50 (µMol)0.47750.00062.69489.4000AID1850752; AID1858950; AID391186; AID770979
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (32)

Processvia Protein(s)Taxonomy
telomere maintenanceTelomerase reverse transcriptaseHomo sapiens (human)
RNA-templated transcriptionTelomerase reverse transcriptaseHomo sapiens (human)
RNA-templated DNA biosynthetic processTelomerase reverse transcriptaseHomo sapiens (human)
telomere maintenance via telomeraseTelomerase reverse transcriptaseHomo sapiens (human)
mitochondrion organizationTelomerase reverse transcriptaseHomo sapiens (human)
negative regulation of gene expressionTelomerase reverse transcriptaseHomo sapiens (human)
DNA strand elongationTelomerase reverse transcriptaseHomo sapiens (human)
positive regulation of Wnt signaling pathwayTelomerase reverse transcriptaseHomo sapiens (human)
siRNA processingTelomerase reverse transcriptaseHomo sapiens (human)
regulation of protein stabilityTelomerase reverse transcriptaseHomo sapiens (human)
positive regulation of protein bindingTelomerase reverse transcriptaseHomo sapiens (human)
positive regulation of hair cycleTelomerase reverse transcriptaseHomo sapiens (human)
negative regulation of neuron apoptotic processTelomerase reverse transcriptaseHomo sapiens (human)
positive regulation of angiogenesisTelomerase reverse transcriptaseHomo sapiens (human)
positive regulation of glucose importTelomerase reverse transcriptaseHomo sapiens (human)
response to cadmium ionTelomerase reverse transcriptaseHomo sapiens (human)
positive regulation of nitric-oxide synthase activityTelomerase reverse transcriptaseHomo sapiens (human)
establishment of protein localization to telomereTelomerase reverse transcriptaseHomo sapiens (human)
cellular response to hypoxiaTelomerase reverse transcriptaseHomo sapiens (human)
DNA biosynthetic processTelomerase reverse transcriptaseHomo sapiens (human)
replicative senescenceTelomerase reverse transcriptaseHomo sapiens (human)
siRNA transcriptionTelomerase reverse transcriptaseHomo sapiens (human)
positive regulation of G1/S transition of mitotic cell cycleTelomerase reverse transcriptaseHomo sapiens (human)
positive regulation of miRNA transcriptionTelomerase reverse transcriptaseHomo sapiens (human)
positive regulation of transdifferentiationTelomerase reverse transcriptaseHomo sapiens (human)
positive regulation of vascular associated smooth muscle cell proliferationTelomerase reverse transcriptaseHomo sapiens (human)
positive regulation of protein localization to nucleolusTelomerase reverse transcriptaseHomo sapiens (human)
positive regulation of vascular associated smooth muscle cell migrationTelomerase reverse transcriptaseHomo sapiens (human)
negative regulation of endothelial cell apoptotic processTelomerase reverse transcriptaseHomo sapiens (human)
positive regulation of stem cell proliferationTelomerase reverse transcriptaseHomo sapiens (human)
negative regulation of cellular senescenceTelomerase reverse transcriptaseHomo sapiens (human)
negative regulation of extrinsic apoptotic signaling pathway in absence of ligandTelomerase reverse transcriptaseHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (16)

Processvia Protein(s)Taxonomy
tRNA bindingTelomerase reverse transcriptaseHomo sapiens (human)
transcription coactivator bindingTelomerase reverse transcriptaseHomo sapiens (human)
DNA bindingTelomerase reverse transcriptaseHomo sapiens (human)
telomerase activityTelomerase reverse transcriptaseHomo sapiens (human)
telomerase RNA reverse transcriptase activityTelomerase reverse transcriptaseHomo sapiens (human)
RNA bindingTelomerase reverse transcriptaseHomo sapiens (human)
RNA-directed DNA polymerase activityTelomerase reverse transcriptaseHomo sapiens (human)
RNA-dependent RNA polymerase activityTelomerase reverse transcriptaseHomo sapiens (human)
protein bindingTelomerase reverse transcriptaseHomo sapiens (human)
identical protein bindingTelomerase reverse transcriptaseHomo sapiens (human)
protein homodimerization activityTelomerase reverse transcriptaseHomo sapiens (human)
metal ion bindingTelomerase reverse transcriptaseHomo sapiens (human)
protein-folding chaperone bindingTelomerase reverse transcriptaseHomo sapiens (human)
telomerase RNA bindingTelomerase reverse transcriptaseHomo sapiens (human)
template-free RNA nucleotidyltransferaseTelomerase reverse transcriptaseHomo sapiens (human)
telomeric DNA bindingTelomerase reverse transcriptaseHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (14)

Processvia Protein(s)Taxonomy
PML bodyTelomerase reverse transcriptaseHomo sapiens (human)
chromosome, telomeric regionTelomerase reverse transcriptaseHomo sapiens (human)
nucleusTelomerase reverse transcriptaseHomo sapiens (human)
nucleoplasmTelomerase reverse transcriptaseHomo sapiens (human)
telomerase holoenzyme complexTelomerase reverse transcriptaseHomo sapiens (human)
nucleolusTelomerase reverse transcriptaseHomo sapiens (human)
cytosolTelomerase reverse transcriptaseHomo sapiens (human)
plasma membraneTelomerase reverse transcriptaseHomo sapiens (human)
nuclear speckTelomerase reverse transcriptaseHomo sapiens (human)
mitochondrial nucleoidTelomerase reverse transcriptaseHomo sapiens (human)
TERT-RMRP complexTelomerase reverse transcriptaseHomo sapiens (human)
telomerase catalytic core complexTelomerase reverse transcriptaseHomo sapiens (human)
nuclear telomere cap complexTelomerase reverse transcriptaseHomo sapiens (human)
RNA-directed RNA polymerase complexTelomerase reverse transcriptaseHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (85)

Assay IDTitleYearJournalArticle
AID689938Cytotoxicity in human MGC803 cells by MTT assay2011Journal of medicinal chemistry, Aug-25, Volume: 54, Issue:16
Inhibition of cell proliferation by quindoline derivative (SYUIQ-05) through its preferential interaction with c-myc promoter G-quadruplex.
AID689917Binding affinity to c-myc Pu27 DNA G-quadruplex in human Ramos cells assessed as down regulation of TERT protein expression at 0.05 to 0.1 uM after 4 days by Western blot method2011Journal of medicinal chemistry, Aug-25, Volume: 54, Issue:16
Inhibition of cell proliferation by quindoline derivative (SYUIQ-05) through its preferential interaction with c-myc promoter G-quadruplex.
AID689919Binding affinity to c-myc Pu27 DNA G-quadruplex in human Ramos cells assessed as down regulation of c-myc protein expression at 0.05 to 0.1 uM after 4 days by Western blot method2011Journal of medicinal chemistry, Aug-25, Volume: 54, Issue:16
Inhibition of cell proliferation by quindoline derivative (SYUIQ-05) through its preferential interaction with c-myc promoter G-quadruplex.
AID1363352Growth inhibition of human A549 cells after 72 hrs by MTT assay2018Journal of medicinal chemistry, 11-21, Volume: 61, Issue:22
Discovery, Synthesis, and Evaluation of Oxynitidine Derivatives as Dual Inhibitors of DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1), and Potential Antitumor Agents.
AID689941Antiproliferative activity against human Ramos cells assessed as cell viability after 20 days2011Journal of medicinal chemistry, Aug-25, Volume: 54, Issue:16
Inhibition of cell proliferation by quindoline derivative (SYUIQ-05) through its preferential interaction with c-myc promoter G-quadruplex.
AID1363342Inhibition of recombinant human TDP1 at 100 uM using 5'FAM-AGGATCTAAAAGACTT-BHQ-3' as substrate preincubated for 30 mins followed by substrate addition by fluorescence-based assay2018Journal of medicinal chemistry, 11-21, Volume: 61, Issue:22
Discovery, Synthesis, and Evaluation of Oxynitidine Derivatives as Dual Inhibitors of DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1), and Potential Antitumor Agents.
AID281087Stabilization of Pu27 oligomer by inducing G-quadruplex formation assessed as inhibition of hybridization with Pu27rev by PCR stop assay2007Journal of medicinal chemistry, Apr-05, Volume: 50, Issue:7
Stabilization of G-quadruplex DNA and down-regulation of oncogene c-myc by quindoline derivatives.
AID1445375Stabilization of 5'-FAM/3'-TAMRA labeled c-Myc Pu22 G-quadruplex DNA (unknown origin) assessed as change in melting temperature at 2 uM by FRET assay2017Journal of medicinal chemistry, 07-13, Volume: 60, Issue:13
New Disubstituted Quindoline Derivatives Inhibiting Burkitt's Lymphoma Cell Proliferation by Impeding c-MYC Transcription.
AID1850753Cytotoxicity against human K562 cells assessed as cell viability by MTT assay2022Bioorganic & medicinal chemistry letters, 09-15, Volume: 72Indoloquinolines as scaffolds for the design of potent G-quadruplex ligands.
AID1850752Inhibition of telomerase (unknown origin)2022Bioorganic & medicinal chemistry letters, 09-15, Volume: 72Indoloquinolines as scaffolds for the design of potent G-quadruplex ligands.
AID1445381Inhibition of NM23-H2 binding to 5'-FAM labeled c-Myc Pu27 G-quadruplex DNA (unknown origin) at 10 uM preincubated for 1 hr followed by NM23-H2 addition by electrophoretic mobility shift assay relative to control2017Journal of medicinal chemistry, 07-13, Volume: 60, Issue:13
New Disubstituted Quindoline Derivatives Inhibiting Burkitt's Lymphoma Cell Proliferation by Impeding c-MYC Transcription.
AID282913Induction of G-quadruplex in G-rich human telomere 21 DNA assessed as circular dichroism spectral change at 50 uM2005Journal of medicinal chemistry, Nov-17, Volume: 48, Issue:23
Synthesis and evaluation of quindoline derivatives as G-quadruplex inducing and stabilizing ligands and potential inhibitors of telomerase.
AID711766Binding affinity to human fluorescent labeled oligonucleotide F21T telomeric G-quadruplex DNA assessed as change in melting temperature at 1 uM after 30 secs by FRET assay2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
Disubstituted quinazoline derivatives as a new type of highly selective ligands for telomeric G-quadruplex DNA.
AID391186Inhibition of telomerase in human MCF7 cells by cell-free telomerase repeat amplification protocol assay2008Journal of medicinal chemistry, Oct-23, Volume: 51, Issue:20
5-N-methylated quindoline derivatives as telomeric g-quadruplex stabilizing ligands: effects of 5-N positive charge on quadruplex binding affinity and cell proliferation.
AID689949Binding affinity to c-myc Pu27 DNA G-quadruplex by ITC titration assay2011Journal of medicinal chemistry, Aug-25, Volume: 54, Issue:16
Inhibition of cell proliferation by quindoline derivative (SYUIQ-05) through its preferential interaction with c-myc promoter G-quadruplex.
AID391179Binding affinity to synthetic HTG21 telomere assessed as change in G-qudraplex DNA melting temperature at 2 uM by FRET method2008Journal of medicinal chemistry, Oct-23, Volume: 51, Issue:20
5-N-methylated quindoline derivatives as telomeric g-quadruplex stabilizing ligands: effects of 5-N positive charge on quadruplex binding affinity and cell proliferation.
AID689918Binding affinity to c-myc Pu27 DNA G-quadruplex in human CA46 cells assessed as down regulation of TERT transcription at 0.1 uM after 4 days by qRT-PCR2011Journal of medicinal chemistry, Aug-25, Volume: 54, Issue:16
Inhibition of cell proliferation by quindoline derivative (SYUIQ-05) through its preferential interaction with c-myc promoter G-quadruplex.
AID1369284Stabilization of F21T telomeric G-quadruplex DNA (unknown origin) assessed as change in melting temperature at 1 uM by FRET assay2018Journal of medicinal chemistry, 04-26, Volume: 61, Issue:8
Discovery of Novel Schizocommunin Derivatives as Telomeric G-Quadruplex Ligands That Trigger Telomere Dysfunction and the Deoxyribonucleic Acid (DNA) Damage Response.
AID689921Binding affinity to c-myc Pu27 DNA G-quadruplex in human Ramos cells assessed as down regulation of TERT transcription at 0.1 uM after 4 days by qRT-PCR2011Journal of medicinal chemistry, Aug-25, Volume: 54, Issue:16
Inhibition of cell proliferation by quindoline derivative (SYUIQ-05) through its preferential interaction with c-myc promoter G-quadruplex.
AID1363350Growth inhibition of human CCRF-CEM cells after 72 hrs by MTT assay2018Journal of medicinal chemistry, 11-21, Volume: 61, Issue:22
Discovery, Synthesis, and Evaluation of Oxynitidine Derivatives as Dual Inhibitors of DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1), and Potential Antitumor Agents.
AID689916Binding affinity to c-myc Pu27 DNA G-quadruplex in human CA46 cells assessed as down regulation of c-myc protein expression at 0.05 to 0.1 uM after 4 days by Western blot method2011Journal of medicinal chemistry, Aug-25, Volume: 54, Issue:16
Inhibition of cell proliferation by quindoline derivative (SYUIQ-05) through its preferential interaction with c-myc promoter G-quadruplex.
AID770979Inhibition of telomerase (unknown origin) by TRAP assay2013European journal of medicinal chemistry, Oct, Volume: 68Toward the design of new DNA G-quadruplex ligands through rational analysis of polymorphism and binding data.
AID349731Binding affinity to F21T human telomeric DNA assessed as change in melting temperature at 1 uM by FRET assay2009Journal of medicinal chemistry, May-14, Volume: 52, Issue:9
Isaindigotone derivatives: a new class of highly selective ligands for telomeric G-quadruplex DNA.
AID689922Binding affinity to c-myc Pu27 DNA G-quadruplex in human CA46 cells assessed as down regulation of c-myc transcription at 0.1 uM after 4 days by qRT-PCR2011Journal of medicinal chemistry, Aug-25, Volume: 54, Issue:16
Inhibition of cell proliferation by quindoline derivative (SYUIQ-05) through its preferential interaction with c-myc promoter G-quadruplex.
AID743540Binding affinity to human telomeric G-quadruplex 5'-d(GGG[TTAGGG]3)-3' DNA assessed as induction of conformation conversion from antiparallel to parallel type at 25 uM after 5 mins by circular dichroism spectroscopic analysis2013European journal of medicinal chemistry, May, Volume: 63New quinazoline derivatives for telomeric G-quadruplex DNA: effects of an added phenyl group on quadruplex binding ability.
AID743539Binding affinity to human telomeric G-quadruplex 5'-d(GGG[TTAGGG]3)-3' DNA assessed as change in melting temperature at 25 uM measured at 265 nM wavelength by circular dichroism spectroscopic analysis2013European journal of medicinal chemistry, May, Volume: 63New quinazoline derivatives for telomeric G-quadruplex DNA: effects of an added phenyl group on quadruplex binding ability.
AID1369286Stabilization of F21T telomeric G-quadruplex DNA (unknown origin) at 1 uM in presence of non-fluorescent duplex DNA ds26 by FRET assay2018Journal of medicinal chemistry, 04-26, Volume: 61, Issue:8
Discovery of Novel Schizocommunin Derivatives as Telomeric G-Quadruplex Ligands That Trigger Telomere Dysfunction and the Deoxyribonucleic Acid (DNA) Damage Response.
AID689925Inhibition of NM23-H2 interaction with c-myc mutant promoter DNA expressed in human HeLa cells assessed as dissociation of NM23-H2 from c-myc promoter at 0.05 to 0.1 uM by Ch-IP assay2011Journal of medicinal chemistry, Aug-25, Volume: 54, Issue:16
Inhibition of cell proliferation by quindoline derivative (SYUIQ-05) through its preferential interaction with c-myc promoter G-quadruplex.
AID689947Binding affinity to c-myc Pu27 DNA G-quadruplex assessed as change in melting temperature by FRET assay2011Journal of medicinal chemistry, Aug-25, Volume: 54, Issue:16
Inhibition of cell proliferation by quindoline derivative (SYUIQ-05) through its preferential interaction with c-myc promoter G-quadruplex.
AID1445393Effect on c-Myc DNA translocated chromosome product in human CA46 cells assessed as decrease in amplification of exon-2 at 1 uM after 12 hrs by RT-PCR method2017Journal of medicinal chemistry, 07-13, Volume: 60, Issue:13
New Disubstituted Quindoline Derivatives Inhibiting Burkitt's Lymphoma Cell Proliferation by Impeding c-MYC Transcription.
AID1445392Stabilization of c-Myc G-quadruplex DNA in human CA46 cells assessed as decrease in amplification of exon-1 at 1 uM after 12 hrs by RT-PCR method2017Journal of medicinal chemistry, 07-13, Volume: 60, Issue:13
New Disubstituted Quindoline Derivatives Inhibiting Burkitt's Lymphoma Cell Proliferation by Impeding c-MYC Transcription.
AID1850782Thermal stabilization of c-MYC parallel G4 (Pu27) DNA (unknown origin) assessed as melting temperature by CD spectra analysis2022Bioorganic & medicinal chemistry letters, 09-15, Volume: 72Indoloquinolines as scaffolds for the design of potent G-quadruplex ligands.
AID1858950Inhibition of telomerase derived from human K562 cell extract incubated for 30 mins by TRAP assay2022European journal of medicinal chemistry, Jan-05, Volume: 227Role of basic aminoalkyl chains in the lead optimization of Indoloquinoline alkaloids.
AID689926Inhibition of telomerase-induced telomere shortening in human Ramos cells at 0.1 uM for 16 days by TRF length assay2011Journal of medicinal chemistry, Aug-25, Volume: 54, Issue:16
Inhibition of cell proliferation by quindoline derivative (SYUIQ-05) through its preferential interaction with c-myc promoter G-quadruplex.
AID689945Binding affinity to G-quadruplex HTG21 by PCR stop assay2011Journal of medicinal chemistry, Aug-25, Volume: 54, Issue:16
Inhibition of cell proliferation by quindoline derivative (SYUIQ-05) through its preferential interaction with c-myc promoter G-quadruplex.
AID689924Inhibition of NM23-H2 interaction with wild type c-myc DNA G-quadruplex expressed in human HeLa cells assessed as dissociation of NM23-H2 from c-myc promoter at 0.05 to 0.1 uM by Ch-IP assay2011Journal of medicinal chemistry, Aug-25, Volume: 54, Issue:16
Inhibition of cell proliferation by quindoline derivative (SYUIQ-05) through its preferential interaction with c-myc promoter G-quadruplex.
AID1363349Growth inhibition of human HCT116 cells after 72 hrs by MTT assay2018Journal of medicinal chemistry, 11-21, Volume: 61, Issue:22
Discovery, Synthesis, and Evaluation of Oxynitidine Derivatives as Dual Inhibitors of DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1), and Potential Antitumor Agents.
AID689937Cytotoxicity in human CNE2 cells by MTT assay2011Journal of medicinal chemistry, Aug-25, Volume: 54, Issue:16
Inhibition of cell proliferation by quindoline derivative (SYUIQ-05) through its preferential interaction with c-myc promoter G-quadruplex.
AID689932Induction of senescence in human CA46 cells assessed as gaint cells at 0.05 to 0.1 uM after 16 days by beta galactosidase assay assay2011Journal of medicinal chemistry, Aug-25, Volume: 54, Issue:16
Inhibition of cell proliferation by quindoline derivative (SYUIQ-05) through its preferential interaction with c-myc promoter G-quadruplex.
AID689920Binding affinity to c-myc Pu27 DNA G-quadruplex in human Ramos cells assessed as down regulation of c-myc transcription at 0.1 uM after 4 days by qRT-PCR2011Journal of medicinal chemistry, Aug-25, Volume: 54, Issue:16
Inhibition of cell proliferation by quindoline derivative (SYUIQ-05) through its preferential interaction with c-myc promoter G-quadruplex.
AID689927Inhibition of telomerase-induced telomere shortening in human Ramos cells at 0.05 uM for 16 days by TRF length assay2011Journal of medicinal chemistry, Aug-25, Volume: 54, Issue:16
Inhibition of cell proliferation by quindoline derivative (SYUIQ-05) through its preferential interaction with c-myc promoter G-quadruplex.
AID689939Cytotoxicity in human Bel7402 cells by MTT assay2011Journal of medicinal chemistry, Aug-25, Volume: 54, Issue:16
Inhibition of cell proliferation by quindoline derivative (SYUIQ-05) through its preferential interaction with c-myc promoter G-quadruplex.
AID1363351Growth inhibition of human DU145 cells after 72 hrs by MTT assay2018Journal of medicinal chemistry, 11-21, Volume: 61, Issue:22
Discovery, Synthesis, and Evaluation of Oxynitidine Derivatives as Dual Inhibitors of DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1), and Potential Antitumor Agents.
AID689934Cytotoxicity in human HeLa cells by MTT assay2011Journal of medicinal chemistry, Aug-25, Volume: 54, Issue:16
Inhibition of cell proliferation by quindoline derivative (SYUIQ-05) through its preferential interaction with c-myc promoter G-quadruplex.
AID743538Binding affinity to human biotinylated telomeric G-quadruplex 5'-d(GGG[TTAGGG]3)-3' DNA by surface plasmon resonance analysis2013European journal of medicinal chemistry, May, Volume: 63New quinazoline derivatives for telomeric G-quadruplex DNA: effects of an added phenyl group on quadruplex binding ability.
AID1445391Effect on c-Myc DNA translocated chromosome product in human Raji cells assessed as decrease in amplification of exon-2 at 1 uM after 12 hrs by RT-PCR method2017Journal of medicinal chemistry, 07-13, Volume: 60, Issue:13
New Disubstituted Quindoline Derivatives Inhibiting Burkitt's Lymphoma Cell Proliferation by Impeding c-MYC Transcription.
AID689943Antiproliferative activity against human Ramos cells assessed as cell viability at 0.05 uM after 20 days2011Journal of medicinal chemistry, Aug-25, Volume: 54, Issue:16
Inhibition of cell proliferation by quindoline derivative (SYUIQ-05) through its preferential interaction with c-myc promoter G-quadruplex.
AID281089Inhibition of Pu27 oligomer hybridization with Pu27rev at 18 uM by PCR stop assay2007Journal of medicinal chemistry, Apr-05, Volume: 50, Issue:7
Stabilization of G-quadruplex DNA and down-regulation of oncogene c-myc by quindoline derivatives.
AID1445380Selectivity ratio of Kd for 5'-FAM labeled duplex DNA (unknown origin) to Kd for 5'-FAM labeled c-Myc Pu27 G-quadruplex DNA (unknown origin)2017Journal of medicinal chemistry, 07-13, Volume: 60, Issue:13
New Disubstituted Quindoline Derivatives Inhibiting Burkitt's Lymphoma Cell Proliferation by Impeding c-MYC Transcription.
AID1850754Cytotoxicity against human SW-620 cells assessed as cell viability by MTT assay2022Bioorganic & medicinal chemistry letters, 09-15, Volume: 72Indoloquinolines as scaffolds for the design of potent G-quadruplex ligands.
AID1369288Binding affinity to hairpin duplex DNA (unknown origin) by SPR method2018Journal of medicinal chemistry, 04-26, Volume: 61, Issue:8
Discovery of Novel Schizocommunin Derivatives as Telomeric G-Quadruplex Ligands That Trigger Telomere Dysfunction and the Deoxyribonucleic Acid (DNA) Damage Response.
AID689942Antiproliferative activity against cmyc NHE III1 element-deficient human CA46 cells assessed as cell viability after 20 days2011Journal of medicinal chemistry, Aug-25, Volume: 54, Issue:16
Inhibition of cell proliferation by quindoline derivative (SYUIQ-05) through its preferential interaction with c-myc promoter G-quadruplex.
AID281091Inhibition of Pu27-13, 14 oligomer hybridization with Pu27rev at 36 uM by PCR stop assay2007Journal of medicinal chemistry, Apr-05, Volume: 50, Issue:7
Stabilization of G-quadruplex DNA and down-regulation of oncogene c-myc by quindoline derivatives.
AID689930Induction of senescence in human Ramos cells assessed as gaint cells at 0.05 to 0.1 uM after 16 days by beta galactosidase assay2011Journal of medicinal chemistry, Aug-25, Volume: 54, Issue:16
Inhibition of cell proliferation by quindoline derivative (SYUIQ-05) through its preferential interaction with c-myc promoter G-quadruplex.
AID689928Inhibition of telomerase-induced telomere shortening in human Ramos cells at 0.05 to 0.1 uM for 16 days by TRF length assay2011Journal of medicinal chemistry, Aug-25, Volume: 54, Issue:16
Inhibition of cell proliferation by quindoline derivative (SYUIQ-05) through its preferential interaction with c-myc promoter G-quadruplex.
AID711764Binding affinity to hairpin fluorescent labeled oligonucleotide F10T telomeric G-quadruplex DNA assessed as change in melting temperature at 1 uM after 30 secs by FRET assay2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
Disubstituted quinazoline derivatives as a new type of highly selective ligands for telomeric G-quadruplex DNA.
AID743537Binding affinity to human telomeric G-quadruplex 5'-d(GGG[TTAGGG]3)-3' DNA assessed as change in melting temperature at 25 uM measured at 290 nM wavelength by circular dichroism spectroscopic analysis2013European journal of medicinal chemistry, May, Volume: 63New quinazoline derivatives for telomeric G-quadruplex DNA: effects of an added phenyl group on quadruplex binding ability.
AID391180Inhibition of amplification of synthetic HTG21 telomere assessed as G-quadruplex stabilization by PCR2008Journal of medicinal chemistry, Oct-23, Volume: 51, Issue:20
5-N-methylated quindoline derivatives as telomeric g-quadruplex stabilizing ligands: effects of 5-N positive charge on quadruplex binding affinity and cell proliferation.
AID1363340Inhibition of recombinant TOP1 (unknown origin)-mediated 3'-[32P]-labeled 117-bp DNA oligonucleotide cleavage assessed as induction of protein-DNA covalent cleavage complex formation at 1 uM after 20 mins by PAGE analysis relative to camptothecin2018Journal of medicinal chemistry, 11-21, Volume: 61, Issue:22
Discovery, Synthesis, and Evaluation of Oxynitidine Derivatives as Dual Inhibitors of DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1), and Potential Antitumor Agents.
AID689931Induction of senescence in human CA46 cells assessed as flat cells at 0.05 to 0.1 uM after 16 days by beta galactosidase assay2011Journal of medicinal chemistry, Aug-25, Volume: 54, Issue:16
Inhibition of cell proliferation by quindoline derivative (SYUIQ-05) through its preferential interaction with c-myc promoter G-quadruplex.
AID1363345Binding affinity to F10T dsDNA (unknown origin) assessed as change in melting temperature at 2 uM after 0.5 hrs by FRET assay2018Journal of medicinal chemistry, 11-21, Volume: 61, Issue:22
Discovery, Synthesis, and Evaluation of Oxynitidine Derivatives as Dual Inhibitors of DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1), and Potential Antitumor Agents.
AID282911Inhibition of telomerase by TRAP assay2005Journal of medicinal chemistry, Nov-17, Volume: 48, Issue:23
Synthesis and evaluation of quindoline derivatives as G-quadruplex inducing and stabilizing ligands and potential inhibitors of telomerase.
AID689948Binding affinity to c-myc Pu27 DNA G-quadruplex by PCR stop assay2011Journal of medicinal chemistry, Aug-25, Volume: 54, Issue:16
Inhibition of cell proliferation by quindoline derivative (SYUIQ-05) through its preferential interaction with c-myc promoter G-quadruplex.
AID689933Cytotoxicity in human GLC82 cells by MTT assay2011Journal of medicinal chemistry, Aug-25, Volume: 54, Issue:16
Inhibition of cell proliferation by quindoline derivative (SYUIQ-05) through its preferential interaction with c-myc promoter G-quadruplex.
AID689935Cytotoxicity in human HL60 cells by MTT assay2011Journal of medicinal chemistry, Aug-25, Volume: 54, Issue:16
Inhibition of cell proliferation by quindoline derivative (SYUIQ-05) through its preferential interaction with c-myc promoter G-quadruplex.
AID282912Dissociation constant, pKa of the compound2005Journal of medicinal chemistry, Nov-17, Volume: 48, Issue:23
Synthesis and evaluation of quindoline derivatives as G-quadruplex inducing and stabilizing ligands and potential inhibitors of telomerase.
AID689946Binding affinity to G-quadruplex HTG21 by ITC titration assay2011Journal of medicinal chemistry, Aug-25, Volume: 54, Issue:16
Inhibition of cell proliferation by quindoline derivative (SYUIQ-05) through its preferential interaction with c-myc promoter G-quadruplex.
AID689929Induction of senescence in human Ramos cells assessed as flat cells at 0.05 to 0.1 uM after 16 days by beta galactosidase assay2011Journal of medicinal chemistry, Aug-25, Volume: 54, Issue:16
Inhibition of cell proliferation by quindoline derivative (SYUIQ-05) through its preferential interaction with c-myc promoter G-quadruplex.
AID1363353Growth inhibition of human HuH7 cells after 72 hrs by MTT assay2018Journal of medicinal chemistry, 11-21, Volume: 61, Issue:22
Discovery, Synthesis, and Evaluation of Oxynitidine Derivatives as Dual Inhibitors of DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1), and Potential Antitumor Agents.
AID349732Binding affinity to F10T hairpin duplex DNA assessed as change in melting temperature at 1 uM by FRET assay2009Journal of medicinal chemistry, May-14, Volume: 52, Issue:9
Isaindigotone derivatives: a new class of highly selective ligands for telomeric G-quadruplex DNA.
AID689950Inhibition of POT1 interaction with wild type c-myc DNA G-quadruplex expressed in human HeLa cells assessed as dissociation of POT1 from c-myc promoter at 0.05 to 0.1 uM by Ch-IP assay2011Journal of medicinal chemistry, Aug-25, Volume: 54, Issue:16
Inhibition of cell proliferation by quindoline derivative (SYUIQ-05) through its preferential interaction with c-myc promoter G-quadruplex.
AID711763Binding affinity to human fluorescent labeled oligonucleotide F21T telomeric G-quadruplex DNA assessed as change in melting temperature at 1 uM by FRET assay in presence of duplex DNA competitor ds262012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
Disubstituted quinazoline derivatives as a new type of highly selective ligands for telomeric G-quadruplex DNA.
AID1369287Binding affinity to HTG21 telomeric G-quadruplex DNA (unknown origin) by SPR method2018Journal of medicinal chemistry, 04-26, Volume: 61, Issue:8
Discovery of Novel Schizocommunin Derivatives as Telomeric G-Quadruplex Ligands That Trigger Telomere Dysfunction and the Deoxyribonucleic Acid (DNA) Damage Response.
AID1445390Stabilization of c-Myc G-quadruplex DNA in human Raji cells assessed as decrease in amplification of exon-1 at 1 uM after 12 hrs by RT-PCR method2017Journal of medicinal chemistry, 07-13, Volume: 60, Issue:13
New Disubstituted Quindoline Derivatives Inhibiting Burkitt's Lymphoma Cell Proliferation by Impeding c-MYC Transcription.
AID689923Inhibition of NM23-H2 interaction with c-myc DNA G-quadruplex in human HeLa cells assessed as inhibition of c-myc expression at 0.1 uM measured by quantitative RT-PCR analysis2011Journal of medicinal chemistry, Aug-25, Volume: 54, Issue:16
Inhibition of cell proliferation by quindoline derivative (SYUIQ-05) through its preferential interaction with c-myc promoter G-quadruplex.
AID349730Binding affinity to oligonucleotide HTG21 by florescence titration assay in presence of K+ solution2009Journal of medicinal chemistry, May-14, Volume: 52, Issue:9
Isaindigotone derivatives: a new class of highly selective ligands for telomeric G-quadruplex DNA.
AID1445378Binding affinity to 5'-FAM labeled c-Myc Pu27 G-quadruplex DNA (unknown origin) in presence of K+ ions by MST analysis2017Journal of medicinal chemistry, 07-13, Volume: 60, Issue:13
New Disubstituted Quindoline Derivatives Inhibiting Burkitt's Lymphoma Cell Proliferation by Impeding c-MYC Transcription.
AID689940Cytotoxicity in human SUNE1 cells by MTT assay2011Journal of medicinal chemistry, Aug-25, Volume: 54, Issue:16
Inhibition of cell proliferation by quindoline derivative (SYUIQ-05) through its preferential interaction with c-myc promoter G-quadruplex.
AID689944Binding affinity to G-quadruplex HTG21 assessed as change in melting temperature by FRET assay2011Journal of medicinal chemistry, Aug-25, Volume: 54, Issue:16
Inhibition of cell proliferation by quindoline derivative (SYUIQ-05) through its preferential interaction with c-myc promoter G-quadruplex.
AID743535Binding affinity to biotinylated duplex DNA (unknown origin) by surface plasmon resonance analysis2013European journal of medicinal chemistry, May, Volume: 63New quinazoline derivatives for telomeric G-quadruplex DNA: effects of an added phenyl group on quadruplex binding ability.
AID1850751Thermal stabilization of G4 quadruplex DNA (unknown origin) assessed as melting temperature by FRET method2022Bioorganic & medicinal chemistry letters, 09-15, Volume: 72Indoloquinolines as scaffolds for the design of potent G-quadruplex ligands.
AID1369285Stabilization of F10T hairpin duplex DNA (unknown origin) assessed as change in melting temperature at 1 uM by FRET assay2018Journal of medicinal chemistry, 04-26, Volume: 61, Issue:8
Discovery of Novel Schizocommunin Derivatives as Telomeric G-Quadruplex Ligands That Trigger Telomere Dysfunction and the Deoxyribonucleic Acid (DNA) Damage Response.
AID689936Cytotoxicity in human K562 cells by MTT assay2011Journal of medicinal chemistry, Aug-25, Volume: 54, Issue:16
Inhibition of cell proliferation by quindoline derivative (SYUIQ-05) through its preferential interaction with c-myc promoter G-quadruplex.
AID1346986P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1346987P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (14)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (28.57)29.6817
2010's8 (57.14)24.3611
2020's2 (14.29)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.09

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.09 (24.57)
Research Supply Index2.71 (2.92)
Research Growth Index4.80 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.09)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (14.29%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other12 (85.71%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
thalidomide
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.. thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.. 2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.		3.5110phthalimides;
piperidones
ethidium bromide
[no description available]		2.1710organic bromide saltgeroprotector;
intercalator;
trypanocidal drug
camptothecin
NSC 100880: carboxylate (opened lactone) form of camptothecin; RN refers to (S)-isomer; structure given in first source		2.1710delta-lactone;
pyranoindolizinoquinoline;
quinoline alkaloid;
tertiary alcohol		antineoplastic agent;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
genotoxin;
plant metabolite
meridine
meridine: polycyclic alkaloid derived from the marine sponge Corticium sp; structure given in first source		2.0810
cryptolepine
cryptolepine: fused indole-quinoline; structure in first source; from CRYPTOLEPIS sanguinolenta. cryptolepine : An organic heterotetracyclic compound that is 5H-indolo[3,2-b]quinoline in which the hydrogen at position N-5 is replaced by a methyl group.		4.5130indole alkaloid;
organic heterotetracyclic compound;
organonitrogen heterocyclic compound		anti-inflammatory agent;
antimalarial;
antineoplastic agent;
cysteine protease inhibitor;
plant metabolite
oxynitidine
oxynitidine: structure in frist source		2.1710
quindoline
quindoline: a fused indole-quinoline alkaloid from CRYPTOLEPIS sanguinolenta; structure		3.5920
isocryptolepine
isocryptolepine: synthetic antimalarial alkaloid; structure in first source		3.5110
neocryptolepine
neocryptolepine: isolated from the roots of the African plant Cryptolepis sanguinolenta; structure in first source		3.5110
nsc 706744
[no description available]		2.1710
ascorbic acid
Ascorbic Acid: A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.. L-ascorbic acid : The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate.. L-ascorbate : The L-enantiomer of ascorbate and conjugate base of L-ascorbic acid, arising from selective deprotonation of the 3-hydroxy group. Required for a range of essential metabolic reactions in all animals and plants.. vitamin C : Any member of a group of vitamers that belong to the chemical structural class called butenolides that exhibit biological activity against vitamin C deficiency in animals. The vitamers include L-ascorbic acid and its salt, ionized and oxidized forms.		3.5110ascorbic acid;
vitamin C		coenzyme;
cofactor;
flour treatment agent;
food antioxidant;
food colour retention agent;
geroprotector;
plant metabolite;
skin lightening agent
ConditionIndicatedRelationship StrengthStudiesTrials
African Lymphoma
[description not available]		02.1510
Experimental Neoplasms
[description not available]		02.1510
Burkitt Lymphoma
A form of undifferentiated malignant LYMPHOMA usually found in central Africa, but also reported in other parts of the world. It is commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass. B-cell antigens are expressed on the immature cells that make up the tumor in virtually all cases of Burkitt lymphoma. The Epstein-Barr virus (HERPESVIRUS 4, HUMAN) has been isolated from Burkitt lymphoma cases in Africa and it is implicated as the causative agent in these cases; however, most non-African cases are EBV-negative.		02.1510
Cancer of Cervix
[description not available]		02.1710
Uterine Cervical Neoplasms
Tumors or cancer of the UTERINE CERVIX.		02.1710
Infections, Plasmodium
[description not available]		03.3310
Benign Neoplasms
[description not available]		03.3310
Malaria
A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.		03.3310
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		03.3310