An EC 3.1.1.* (carboxylic ester hydrolase) inhibitor that interferes with the action of cholinesterase (EC 3.1.1.8).
| Member | Definition | Class |
|---|
| 11-hydroxysugiol | An abietane diterpenoid that is sugiol in which the hydrogen ortho to the phenolic hydroxy group has been replaced by a hydroxy group. | 11-hydroxysugiol |
| alternariol | A benzochromenone that is 6H-benzo[c]chromen-6-one which is substituted by a methyl group at position 1 and by hydroxy groups at positions 3, 7, and 9. It is the most important mycotoxin produced by the black mould Alternaria species, which are the most common mycoflora infecting small grain cereals worldwide. | alternariol |
| ambenonium | A symmetrical oxalamide-based bis-quaternary ammonium ion having ethyl and 2-chlorobenzyl groups attached to the nitrogens. | ambenonium |
| ambenonium chloride | A symmetrical oxalamide-based bis-quaternary ammonium salt having ethyl and 2-chlorobenzyl groups attached to the nitrogens. | ambenonium chloride |
| azinphosmethyl | A member of the class of benzotriazines that is 1,2,3-benzotriazine substituted by an oxo group at position 4 and a [(dimethoxyphosphorothioyl)sulfanyl]methyl group at position 3. | azinphos-methyl |
| berberine | | berberine |
| bupivacaine hydrochloride | A racemate composed of equimolar amounts of dextrobupivacaine hydrochloride and levobupivacaine hydrochloride. The monohydrate form is commonly used as a local anaesthetic. | 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide hydrochloride; bupivacaine hydrochloride (anhydrous) |
| carbaryl | A carbamate ester obtained by the formal condensation of 1-naphthol with methylcarbamic acid. | carbaryl |
| carbofuran | | carbofuran |
| chlorfenvinphos | | chlorfenvinfos |
| chlorpyrifos | An organic thiophosphate that is O,O-diethyl hydrogen phosphorothioate in which the hydrogen of the hydroxy group has been replaced by a 3,5,6-trichloropyridin-2-yl group. | chlorpyrifos |
| coumaphos | | coumaphos |
| diazinon | A member of the class of pyrimidines that is pyrimidine carrying an isopropyl group at position 2, a methyl group at position 6 and a (diethoxyphosphorothioyl)oxy group at position 4. | diazinon |
| dichlorvos | An alkenyl phosphate that is the 2,2-dichloroethenyl ester of dimethyl phosphate. | dichlorvos |
| dimethoate | A monocarboxylic acid amide that is N-methylacetamide in which one of the hydrogens of the methyl group attached to the carbonyl moiety is replaced by a (dimethoxyphosphorothioyl)sulfanediyl group. | dimethoate |
| distigmine | A carbamate ester resulting from the formal condensation of both carboxy groups of hexane-1,6-diylbis(methylcarbamic acid) with the hydroxy group of 3-hydroxy-1-methylpyridinium. | distigmine |
| disulfiram | An organic disulfide that results from the formal oxidative dimerisation of N,N-diethyldithiocarbamic acid. A multi-enzyme inhibitor that is used in alcohol aversion therapy and also exhibits anticancer properties. | disulfiram |
| donepezil | A racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine. | 2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one; donepezil |
| echothiophate iodide | The iodide salt of ecothiopate. An irreversible acetylcholinesterase inhibitor, it is used an ocular antihypertensive in the treatment of open-angle glaucoma, particularly when other drugs have proved inadequate. | ecothiopate iodide |
| edrophonium | A quaternary ammonium ion that is N-ethyl-N,N-dimethylanilinium in which one of the meta positions is substituted by a hydroxy group. It is a reversible inhibitor of cholinesterase, with a rapid onset (30-60 seconds after injection) but a short duration of action (5-15 minutes). The chloride salt is used in myasthenia gravis both diagnostically and to distinguish between under- or over-treatment with other anticholinesterases. It has also been used for the reversal of neuromuscular blockade in anaesthesia, and for the management of poisoning due to tetrodotoxin, a neuromuscular blocking toxin found in puffer fish and other marine animals. | edrophonium |
| edrophonium chloride | The chloride salt of edrophonium. A reversible inhibitor of cholinesterase with a rapid onset (30-60 seconds after injection) but a short duration of action (5-15 minutes), it is used in myasthenia gravis both diagnostically and to distinguish between under- or over-treatment with other anticholinesterases. It has also been used for the reversal of neuromuscular blockade in anaesthesia, and for the management of poisoning due to tetrodotoxin, a neuromuscular blocking toxin found in puffer fish and other marine animals. | edrophonium chloride |
| fenitrothion | An organic thiophosphate that is O,O-dimethyl O-phenyl phosphorothioate substituted by a methyl group at position 3 and a nitro group at position 4. | fenitrothion |
| fenthion | An organic thiophosphate that is O,O-dimethyl hydrogen phosphorothioate in which the hydrogen atom of the hydroxy group is replaced by a 3-methyl-4-(methylsulfanyl)phenyl group. It exhibits acaricidal and insecticidal activities. | fenthion |
| fonofos | | fonofos |
| galantamine | A benzazepine alkaloid isolated from certain species of daffodils. | galanthamine |
| levobupivacaine | The (S)-(-)-enantiomer of bupivacaine. | levobupivacaine |
| levobupivacaine hydrochloride | The monohydrochloride salt of levobupivacaine. | levobupivacaine hydrochloride (anhydrous) |
| lucidenic acid n | A tetracyclic triterpenoid that is 25,26,27-trinorlanost-8-en-24-oic acid substituted by hydroxy groups at positions 3 and 7 and oxo groups at positions 11 and 15 respectively (the 3beta,5alpha,7beta stereoisomer). Isolated from the fruiting bodies of Ganoderma lucidum, it exhibits cytotoxicity against tumour cells. | lucidenic acid N |
| methomyl | A carbamate ester obtained by the formal condensation of methylcarbamic acid with the hydroxy group of 1-(methylsulfanyl)acetaldoxime. | methomyl |
| methyl parathion | A C-nitro compound that is 4-nitrophenol substituted by a (dimethoxyphosphorothioyl)oxy group at position 4. | parathion-methyl |
| methylene blue | An organic chloride salt having 3,7-bis(dimethylamino)phenothiazin-5-ium as the counterion. A commonly used dye that also exhibits antioxidant, antimalarial, antidepressant and cardioprotective properties. | methylene blue |
| monocrotophos | An alkenyl phosphate that is the 4-(methylamino)-4-oxobut-2-en-2-yl ester of dimethyl phosphate. | monocrotophos |
| naled | An dialkyl phosphate resulting from the formal condensation of the acidic hydroxy group of dimethyl hydrogen phosphate with the alcoholic hydroxy group of 1,2-dibromo-2,2-dichloroethanol. An organophosphate insecticide, it is no longer approved for use within the European Union. | naled |
| neostigmine methylsulfate | | neostigmine methyl sulfate |
| nostocarboline | A member of the class of beta-carbolines that is 9H-beta-carbolin-2-ium substituted by a chloro group at position 6 and a methyl group at position 2. It is isolated from a fresh water cyanobacterium Nostoc 78-12A and acts as an inhibitor of butyrylcholinesterase. | nostocarboline |
| parathion | | parathion |
| phorate | | phorate |
| phosalone | A member of the class of 1,3-benzoxazoles carrying a [(diethoxyphosphorothioyl)sulfanyl]methyl group at the nitrogen atom, an oxo group at position 2 and a chloro group at position 6. It is an organothiophosphate insecticide. | phosalone |
| physostigmine | | physostigmine |
| prothiophos | An organic thiophosphate that is the 2,4-dichlorophenyl ester of O-ethyl S-propyl dithiophosphoric acid. | prothiofos |
| rivastigmine | A carbamate ester obtained by formal condensation of the carboxy group of ethyl(methyl)carbamic acid with the phenolic OH group of 3-[(1S)-1-(dimethylamino)ethyl]phenol. A reversible cholinesterase inhibitor. | rivastigmine |
| sulfotepp | | sulfotep |
| tetrachlorvinphos | | tetrachlorvinphos |
| trichlorfon | A phosphonic ester that is dimethyl phosphonate in which the hydrogen atom attched to the phosphorous is substituted by a 2,2,2-trichloro-1-hydroxyethyl group. | trichlorfon |
| tyramine | A primary amino compound obtained by formal decarboxylation of the amino acid tyrosine. | tyramine |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 13.4360 | 1 | 9 |
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 15.5288 | 1 | 6 |
| 67.9K protein | Vaccinia virus | Potency | 0.4496 | 2 | 2 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 32.4517 | 4 | 133 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 17.8433 | 1 | 15 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 23.3798 | 1 | 24 |
| Alpha-synuclein | Homo sapiens (human) | Potency | 10.5112 | 1 | 2 |
| Amyloid-beta precursor protein | Homo sapiens (human) | Potency | 5.1735 | 1 | 1 |
| apical membrane antigen 1, AMA1 | Plasmodium falciparum 3D7 | Potency | 14.1254 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 26.0696 | 11 | 154 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 28.7632 | 3 | 60 |
| arylsulfatase A | Homo sapiens (human) | Potency | 37.9330 | 1 | 1 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 12.9584 | 3 | 4 |
| Ataxin-2 | Homo sapiens (human) | Potency | 29.8203 | 2 | 10 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 20.8472 | 2 | 3 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 35.1003 | 2 | 14 |
| atrial natriuretic peptide receptor 1 precursor | Homo sapiens (human) | Potency | 13.1638 | 1 | 2 |
| atrial natriuretic peptide receptor 2 precursor | Homo sapiens (human) | Potency | 5.2119 | 1 | 1 |
| beta-2 adrenergic receptor | Homo sapiens (human) | Potency | 0.6513 | 1 | 1 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 6.4383 | 2 | 5 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 44.9647 | 1 | 2 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 11.2874 | 1 | 4 |
| caspase-3 | Cricetulus griseus (Chinese hamster) | Potency | 29.9490 | 1 | 3 |
| caspase-3 | Homo sapiens (human) | Potency | 11.2874 | 1 | 4 |
| Caspase-7 | Cricetulus griseus (Chinese hamster) | Potency | 29.9490 | 1 | 3 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 39.0168 | 3 | 27 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 20.3636 | 2 | 5 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 35.1406 | 1 | 5 |
| Chain A, ATP-DEPENDENT DNA HELICASE Q1 | Homo sapiens (human) | Potency | 23.7358 | 2 | 2 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 62.6190 | 2 | 3 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 11.6698 | 2 | 7 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 29.2965 | 2 | 7 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 22.7088 | 2 | 14 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 61.0988 | 1 | 6 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 5.6954 | 1 | 6 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 15.4770 | 1 | 8 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 38.1387 | 2 | 6 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 22.7088 | 2 | 14 |
| chaperonin-containing TCP-1 beta subunit homolog | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 56.3267 | 2 | 5 |
| core-binding factor subunit beta isoform 2 | Homo sapiens (human) | Potency | 0.5380 | 2 | 2 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 15.2056 | 1 | 3 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 1.4550 | 1 | 2 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 4.3933 | 1 | 6 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 8.9570 | 1 | 7 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 14.2746 | 1 | 3 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 9.5340 | 2 | 34 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 12.2177 | 2 | 13 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 35.4298 | 1 | 18 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 3.2641 | 1 | 1 |
| D(3) dopamine receptor isoform e | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| DNA dC->dU-editing enzyme APOBEC-3F isoform a | Homo sapiens (human) | Potency | 2.8184 | 1 | 1 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| DNA polymerase eta isoform 1 | Homo sapiens (human) | Potency | 56.2341 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 67.7502 | 1 | 3 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 23.7781 | 1 | 2 |
| dopamine D1 receptor | Homo sapiens (human) | Potency | 5.2552 | 1 | 2 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 31.5956 | 12 | 147 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 27.5177 | 2 | 23 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 29.3487 | 10 | 116 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 22.1469 | 1 | 11 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 4.1981 | 4 | 8 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 25.9624 | 5 | 32 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 65.3443 | 1 | 3 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 21.4842 | 1 | 6 |
| G | Vesicular stomatitis virus | Potency | 4.3933 | 1 | 6 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 9.5340 | 1 | 17 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 9.5340 | 1 | 17 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 9.5340 | 1 | 17 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 9.5340 | 1 | 17 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 9.5340 | 1 | 17 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 9.5340 | 1 | 17 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 9.5340 | 1 | 17 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 9.5340 | 1 | 17 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 9.5340 | 1 | 17 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 9.5340 | 1 | 17 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 9.5340 | 1 | 17 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 9.5340 | 1 | 17 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 9.5340 | 1 | 17 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 9.5340 | 1 | 17 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 9.5340 | 1 | 17 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 9.5340 | 1 | 17 |
| geminin | Homo sapiens (human) | Potency | 11.7930 | 4 | 18 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 16.6354 | 3 | 44 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 14.3484 | 1 | 2 |
| GLS protein | Homo sapiens (human) | Potency | 16.0975 | 2 | 9 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 30.7392 | 4 | 23 |
| glucokinase regulatory protein | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 36.8378 | 1 | 15 |
| Glutamate receptor ionotropic, NMDA 1 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Glycoprotein hormones alpha chain | Homo sapiens (human) | Potency | 16.0620 | 1 | 2 |
| GTP-binding nuclear protein Ran isoform 1 | Homo sapiens (human) | Potency | 1.3609 | 1 | 2 |
| Guanine nucleotide-binding protein G | Homo sapiens (human) | Potency | 27.5020 | 2 | 3 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 27.2955 | 2 | 22 |
| hexokinase-4 isoform 1 | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 7.4828 | 2 | 16 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 25.7232 | 1 | 9 |
| histone deacetylase 9 isoform 3 | Homo sapiens (human) | Potency | 12.2985 | 2 | 7 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 55.0151 | 2 | 26 |
| histone-lysine N-methyltransferase 2A isoform 2 precursor | Homo sapiens (human) | Potency | 29.8816 | 1 | 2 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 4.3933 | 1 | 6 |
| huntingtin isoform 2 | Homo sapiens (human) | Potency | 6.6918 | 1 | 2 |
| hypothetical protein, conserved | Trypanosoma brucei | Potency | 16.8262 | 4 | 8 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 27.1838 | 2 | 17 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 18.3808 | 3 | 3 |
| IDH1 | Homo sapiens (human) | Potency | 6.7720 | 1 | 3 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 30.6156 | 2 | 3 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 4.3933 | 1 | 12 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 14.1476 | 2 | 8 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 18.9156 | 1 | 3 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 18.9156 | 1 | 3 |
| Interferon beta | Homo sapiens (human) | Potency | 13.1850 | 3 | 17 |
| interleukin 8 | Homo sapiens (human) | Potency | 43.9780 | 1 | 2 |
| isocitrate dehydrogenase 1, partial | Homo sapiens (human) | Potency | 51.1190 | 1 | 2 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 11.6431 | 2 | 13 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 12.5331 | 1 | 3 |
| lethal(3)malignant brain tumor-like protein 1 isoform I | Homo sapiens (human) | Potency | 22.1060 | 1 | 2 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 36.1392 | 3 | 26 |
| luciferase | Photuris pensylvanica (Pennsylania firefly) | Potency | 10.0000 | 1 | 1 |
| luteinizing hormone receptor | Homo sapiens (human) | Potency | 84.9214 | 1 | 1 |
| lysosomal alpha-glucosidase preproprotein | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 20.8114 | 1 | 2 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 13.4363 | 2 | 17 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 16.9040 | 2 | 7 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 14.6515 | 2 | 4 |
| muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 14.3151 | 1 | 3 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 9.8226 | 3 | 5 |
| NFKB1 protein, partial | Homo sapiens (human) | Potency | 7.0795 | 2 | 2 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 10.5808 | 1 | 3 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 29.8887 | 4 | 74 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 13.3181 | 1 | 4 |
| nuclear factor NF-kappa-B p105 subunit isoform 1 | Homo sapiens (human) | Potency | 7.7650 | 1 | 3 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 25.7252 | 1 | 15 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 42.5515 | 1 | 4 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 5.6962 | 2 | 14 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 24.9430 | 3 | 98 |
| Ornithine decarboxylase | Rattus norvegicus (Norway rat) | Potency | 25.1189 | 1 | 1 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| Parkin | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 56.2341 | 1 | 1 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 11.8879 | 2 | 12 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 11.9955 | 1 | 1 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 26.6914 | 5 | 36 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 20.6273 | 5 | 15 |
| phosphoglycerate kinase | Trypanosoma brucei brucei TREU927 | Potency | 17.7828 | 1 | 1 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 37.0593 | 3 | 13 |
| PINK1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 7.4140 | 1 | 2 |
| polyprotein | Zika virus | Potency | 21.4842 | 1 | 6 |
| polypyrimidine tract-binding protein 1 isoform a | Homo sapiens (human) | Potency | 14.5500 | 2 | 2 |
| polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | Potency | 12.1291 | 1 | 4 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 11.0994 | 1 | 5 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 29.1750 | 1 | 6 |
| PPM1D protein | Homo sapiens (human) | Potency | 14.5775 | 1 | 6 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 39.5066 | 3 | 51 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 36.8810 | 1 | 6 |
| progesterone receptor | Homo sapiens (human) | Potency | 19.6696 | 2 | 30 |
| pyruvate kinase | Leishmania mexicana mexicana | Potency | 15.8489 | 2 | 2 |
| pyruvate kinase PKM isoform a | Homo sapiens (human) | Potency | 39.8107 | 2 | 2 |
| pyruvate kinase PKM isoform b | Homo sapiens (human) | Potency | 25.1189 | 2 | 2 |
| Rap guanine nucleotide exchange factor 4 | Homo sapiens (human) | Potency | 16.8037 | 1 | 2 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 29.2006 | 2 | 34 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 12.8635 | 1 | 4 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 31.8600 | 3 | 59 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 27.1336 | 4 | 47 |
| runt-related transcription factor 1 isoform AML1b | Homo sapiens (human) | Potency | 0.5380 | 2 | 2 |
| serine-protein kinase ATM isoform a | Homo sapiens (human) | Potency | 18.3828 | 4 | 5 |
| serine/threonine-protein kinase mTOR isoform 1 | Homo sapiens (human) | Potency | 0.7360 | 3 | 3 |
| serine/threonine-protein kinase PLK1 | Homo sapiens (human) | Potency | 17.2876 | 1 | 4 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 18.4559 | 2 | 9 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 18.4559 | 2 | 9 |
| Smad3 | Homo sapiens (human) | Potency | 3.4721 | 1 | 3 |
| snurportin-1 | Homo sapiens (human) | Potency | 30.6156 | 2 | 3 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 20.9910 | 1 | 4 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 15.7154 | 1 | 6 |
| T cell receptor, partial | Homo sapiens (human) | Potency | 6.2841 | 1 | 1 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 18.8160 | 1 | 4 |
| TDP1 protein | Homo sapiens (human) | Potency | 10.6517 | 2 | 33 |
| thioredoxin glutathione reductase | Schistosoma mansoni | Potency | 31.6228 | 1 | 1 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 17.7550 | 2 | 7 |
| Thrombopoietin | Homo sapiens (human) | Potency | 0.3981 | 2 | 2 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 40.0293 | 3 | 36 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 21.0940 | 8 | 16 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 28.6280 | 7 | 81 |
| thyrotropin-releasing hormone receptor | Homo sapiens (human) | Potency | 23.5267 | 2 | 3 |
| TSHR protein | Homo sapiens (human) | Potency | 15.5035 | 2 | 2 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 7.4140 | 1 | 2 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 7.4140 | 1 | 2 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 47.3824 | 1 | 6 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 25.1243 | 2 | 34 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 20.6134 | 5 | 23 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 34.4882 | 1 | 17 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 36.8378 | 1 | 15 |
| Vpr | Human immunodeficiency virus 1 | Potency | 29.2938 | 1 | 3 |
| WRN | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a | Homo sapiens (human) | IC50 | 4.2905 | 2 | 2 |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | IC50 | 7.4200 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | IC50 | 34.5470 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | Ki | 21.9840 | 1 | 1 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | IC50 | 16.0010 | 1 | 1 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | Ki | 7.4290 | 1 | 1 |
| Acetylcholine receptor subunit epsilon | Homo sapiens (human) | IC50 | 0.0324 | 1 | 1 |
| Acetylcholine receptor subunit epsilon | Rattus norvegicus (Norway rat) | IC50 | 9.0000 | 1 | 1 |
| Acetylcholinesterase | Anopheles gambiae (African malaria mosquito) | IC50 | 0.1920 | 2 | 2 |
| Acetylcholinesterase | Electrophorus electricus (electric eel) | IC50 | 7.8476 | 254 | 314 |
| Acetylcholinesterase | Gallus gallus (chicken) | IC50 | 0.0200 | 1 | 1 |
| Acetylcholinesterase | Homo sapiens (human) | IC50 | 8.0551 | 244 | 332 |
| Acetylcholinesterase | Mus musculus (house mouse) | IC50 | 4.1938 | 14 | 15 |
| Acetylcholinesterase | Rattus norvegicus (Norway rat) | IC50 | 2.4483 | 38 | 50 |
| Acetylcholinesterase | Tetronarce californica (Pacific electric ray) | IC50 | 12.0073 | 14 | 16 |
| Acetylcholinesterase | Electrophorus electricus (electric eel) | Ki | 0.6637 | 10 | 10 |
| Acetylcholinesterase | Homo sapiens (human) | Ki | 8.2764 | 22 | 27 |
| Acetylcholinesterase | Mus musculus (house mouse) | Ki | 1.9767 | 2 | 3 |
| Acetylcholinesterase | Tetronarce californica (Pacific electric ray) | Ki | 16.0950 | 1 | 2 |
| Acetylcholinesterase | Bos taurus (cattle) | IC50 | 0.9064 | 11 | 15 |
| Acetylcholinesterase | Drosophila melanogaster (fruit fly) | IC50 | 1.8300 | 1 | 1 |
| Acetylcholinesterase | Bos taurus (cattle) | Ki | 0.0029 | 2 | 2 |
| Acyl-CoA desaturase 1 | Rattus norvegicus (Norway rat) | IC50 | 1.7100 | 1 | 1 |
| Acyl-CoA:cholesterol acyltransferase | Oryctolagus cuniculus (rabbit) | IC50 | 0.0134 | 1 | 2 |
| Adenosine receptor A3 | Homo sapiens (human) | IC50 | 0.3560 | 1 | 1 |
| Adenosine receptor A3 | Homo sapiens (human) | Ki | 0.2010 | 1 | 1 |
| Aldehyde dehydrogenase, mitochondrial | Homo sapiens (human) | IC50 | 3.4000 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | IC50 | 70.3700 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | Ki | 69.8120 | 1 | 1 |
| Aldo-keto reductase family 1 member C2 | Homo sapiens (human) | IC50 | 6.7100 | 1 | 1 |
| Aldo-keto reductase family 1 member C3 | Homo sapiens (human) | IC50 | 4.9900 | 2 | 2 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.5710 | 3 | 3 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.2010 | 1 | 1 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.5710 | 3 | 3 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.2010 | 1 | 1 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.6785 | 2 | 2 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | IC50 | 4.9040 | 1 | 1 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | Ki | 1.8390 | 1 | 1 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | IC50 | 3.2180 | 1 | 1 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | Ki | 1.4690 | 1 | 1 |
| Amine oxidase [flavin-containing] A | Homo sapiens (human) | IC50 | 465.9510 | 4 | 4 |
| Amine oxidase [flavin-containing] A | Bos taurus (cattle) | IC50 | 828.0000 | 1 | 1 |
| Amine oxidase [flavin-containing] A | Rattus norvegicus (Norway rat) | IC50 | 214.9312 | 4 | 8 |
| Amine oxidase [flavin-containing] B | Homo sapiens (human) | IC50 | 17.7333 | 3 | 3 |
| Amine oxidase [flavin-containing] B | Rattus norvegicus (Norway rat) | IC50 | 124.6071 | 5 | 7 |
| Amyloid-beta precursor protein | Homo sapiens (human) | IC50 | 0.2610 | 2 | 2 |
| Angiotensin-converting enzyme 2 | Homo sapiens (human) | IC50 | 9.3500 | 1 | 1 |
| apelin receptor | Homo sapiens (human) | IC50 | 2.6300 | 1 | 1 |
| Apoptotic peptidase activating factor 1 | Homo sapiens (human) | IC50 | 57.7500 | 2 | 2 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 4 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | IC50 | 34.8500 | 1 | 1 |
| Beta-secretase 1 | Homo sapiens (human) | IC50 | 3.3033 | 6 | 7 |
| bifunctional UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase | Mycobacterium tuberculosis H37Rv | IC50 | 85.0300 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 219.2556 | 4 | 9 |
| Bile salt export pump | Rattus norvegicus (Norway rat) | IC50 | 759.6500 | 1 | 2 |
| C-C chemokine receptor type 2 | Homo sapiens (human) | IC50 | 2.4680 | 1 | 1 |
| C-C chemokine receptor type 2 | Homo sapiens (human) | Ki | 0.9540 | 1 | 1 |
| C-C chemokine receptor type 4 | Homo sapiens (human) | IC50 | 8.3950 | 1 | 1 |
| C-C chemokine receptor type 4 | Homo sapiens (human) | Ki | 4.3970 | 1 | 1 |
| C-C chemokine receptor type 5 | Homo sapiens (human) | IC50 | 23.6610 | 1 | 1 |
| C-C chemokine receptor type 5 | Homo sapiens (human) | Ki | 18.2840 | 1 | 1 |
| C-X-C chemokine receptor type 2 | Homo sapiens (human) | IC50 | 6.0130 | 1 | 1 |
| C-X-C chemokine receptor type 2 | Homo sapiens (human) | Ki | 4.2090 | 1 | 1 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4D | Homo sapiens (human) | IC50 | 36.0000 | 1 | 1 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 4 |
| Carbamate kinase | Giardia intestinalis | IC50 | 0.6000 | 1 | 1 |
| Carbonic anhydrase 1 | Homo sapiens (human) | Ki | 61.7000 | 1 | 1 |
| Carbonic anhydrase 12 | Homo sapiens (human) | Ki | 9.5200 | 1 | 1 |
| Carbonic anhydrase 13 | Homo sapiens (human) | Ki | 4.2300 | 1 | 1 |
| Carbonic anhydrase 14 | Homo sapiens (human) | Ki | 4.1400 | 1 | 1 |
| Carbonic anhydrase 2 | Homo sapiens (human) | Ki | 200.0000 | 1 | 1 |
| Carbonic anhydrase 3 | Homo sapiens (human) | Ki | 4.6200 | 1 | 1 |
| Carbonic anhydrase 4 | Homo sapiens (human) | Ki | 5.4800 | 1 | 1 |
| Carbonic anhydrase 5A, mitochondrial | Homo sapiens (human) | Ki | 5.0900 | 1 | 1 |
| Carbonic anhydrase 5B, mitochondrial | Homo sapiens (human) | Ki | 3.4100 | 1 | 1 |
| Carbonic anhydrase 6 | Homo sapiens (human) | Ki | 2.2300 | 1 | 1 |
| Carbonic anhydrase 7 | Homo sapiens (human) | Ki | 4.6800 | 1 | 1 |
| Carbonic anhydrase 9 | Homo sapiens (human) | Ki | 6.4100 | 1 | 1 |
| Carboxylic ester hydrolase | Equus caballus (horse) | IC50 | 7.1514 | 14 | 17 |
| Carboxylic ester hydrolase | Musca domestica (house fly) | IC50 | 9.5100 | 1 | 1 |
| Carboxylic ester hydrolase | Plutella xylostella (diamondback moth) | IC50 | 1,355.5000 | 2 | 2 |
| Carboxylic ester hydrolase | Rattus norvegicus (Norway rat) | IC50 | 12.9958 | 16 | 19 |
| Carboxylic ester hydrolase | Equus caballus (horse) | Ki | 3.0933 | 3 | 3 |
| Caspase-1 | Homo sapiens (human) | IC50 | 1.8000 | 1 | 1 |
| caspase-3 isoform a preproprotein | Homo sapiens (human) | IC50 | 17.0000 | 1 | 1 |
| caspase-9 isoform alpha precursor | Homo sapiens (human) | IC50 | 17.0000 | 1 | 1 |
| cGMP-specific 3',5'-cyclic phosphodiesterase | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Chain A, ACETYLCHOLINESTERASE | Tetronarce californica (Pacific electric ray) | IC50 | 0.5060 | 1 | 2 |
| Chain E, Fibrin beta chain | Homo sapiens (human) | IC50 | 46.2655 | 2 | 2 |
| Choline O-acetyltransferase | Rattus norvegicus (Norway rat) | IC50 | 0.0053 | 1 | 1 |
| Cholinesterase | Canis lupus familiaris (dog) | IC50 | 6.2700 | 1 | 1 |
| Cholinesterase | Equus caballus (horse) | IC50 | 7.8788 | 177 | 201 |
| Cholinesterase | Homo sapiens (human) | IC50 | 216,097,029,848.7245 | 148 | 202 |
| Cholinesterase | Mus musculus (house mouse) | IC50 | 0.8420 | 5 | 5 |
| Cholinesterase | Equus caballus (horse) | Ki | 3.2937 | 3 | 3 |
| Cholinesterase | Homo sapiens (human) | Ki | 25.1591 | 8 | 10 |
| Cruzipain | Trypanosoma cruzi | IC50 | 70.0000 | 2 | 2 |
| Cytochrome P450 1A2 | Homo sapiens (human) | IC50 | 4.0000 | 1 | 1 |
| Cytochrome P450 1B1 | Homo sapiens (human) | IC50 | 4.5410 | 4 | 4 |
| Cytochrome P450 1B1 | Homo sapiens (human) | Ki | 0.0440 | 1 | 1 |
| Cytochrome P450 2D6 | Homo sapiens (human) | IC50 | 0.2655 | 1 | 3 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 33.7050 | 2 | 2 |
| D(1A) dopamine receptor | Homo sapiens (human) | IC50 | 2.1580 | 1 | 1 |
| D(1A) dopamine receptor | Homo sapiens (human) | Ki | 260.3597 | 2 | 3 |
| D(2) dopamine receptor | Homo sapiens (human) | IC50 | 23.0180 | 1 | 1 |
| D(2) dopamine receptor | Homo sapiens (human) | Ki | 83.8365 | 2 | 2 |
| D(3) dopamine receptor | Homo sapiens (human) | IC50 | 1.0840 | 1 | 1 |
| D(3) dopamine receptor | Homo sapiens (human) | Ki | 0.3680 | 1 | 1 |
| D(4) dopamine receptor | Homo sapiens (human) | IC50 | 3.1500 | 1 | 1 |
| D(4) dopamine receptor | Homo sapiens (human) | Ki | 1.1050 | 1 | 1 |
| Delta-type opioid receptor | Mus musculus (house mouse) | IC50 | 14.6317 | 1 | 5 |
| Dihydrolipoyl dehydrogenase | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 1,000.0000 | 1 | 1 |
| Dihydrolipoyl dehydrogenase, mitochondrial | Sus scrofa (pig) | IC50 | 1,000.0000 | 1 | 1 |
| Fatty-acid amide hydrolase 1 | Homo sapiens (human) | IC50 | 141.0260 | 3 | 3 |
| Fructose-1,6-bisphosphatase 1 | Homo sapiens (human) | IC50 | 101.2380 | 10 | 10 |
| Gasdermin-D | Homo sapiens (human) | IC50 | 0.4000 | 1 | 1 |
| Gasdermin-D | Mus musculus (house mouse) | IC50 | 0.4000 | 1 | 1 |
| glucose-6-phosphate 1-dehydrogenase isoform b | Homo sapiens (human) | IC50 | 80.0000 | 1 | 1 |
| glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase | Plasmodium berghei | IC50 | 56.7000 | 3 | 3 |
| Glutathione reductase | Plasmodium falciparum 3D7 | IC50 | 6.4000 | 1 | 1 |
| Glutathione reductase, mitochondrial | Homo sapiens (human) | IC50 | 16.2000 | 2 | 2 |
| Glycogen synthase kinase-3 beta | Homo sapiens (human) | IC50 | 37.0000 | 3 | 3 |
| guanine nucleotide-binding protein subunit alpha-15 | Homo sapiens (human) | IC50 | 29.9020 | 1 | 1 |
| Histamine H3 receptor | Homo sapiens (human) | IC50 | 0.3500 | 1 | 1 |
| Histone-lysine N-methyltransferase EHMT1 | Homo sapiens (human) | IC50 | 1.6000 | 1 | 1 |
| Histone-lysine N-methyltransferase EHMT2 | Homo sapiens (human) | IC50 | 0.6000 | 1 | 1 |
| integrase, partial | Human immunodeficiency virus 1 | IC50 | 19.2405 | 2 | 2 |
| kallikrein-5 preproprotein | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Kappa-type opioid receptor | Cavia porcellus (domestic guinea pig) | IC50 | 3.2000 | 1 | 1 |
| Kappa-type opioid receptor | Homo sapiens (human) | IC50 | 6.1030 | 1 | 1 |
| Kappa-type opioid receptor | Homo sapiens (human) | Ki | 2.4410 | 1 | 1 |
| large T antigen | Betapolyomavirus macacae | IC50 | 10.7300 | 1 | 1 |
| lens epithelium-derived growth factor p75 | Homo sapiens (human) | IC50 | 19.2405 | 2 | 2 |
| Liver carboxylesterase 1 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Lysine-specific demethylase 5A | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Lysine-specific histone demethylase 1A | Homo sapiens (human) | IC50 | 6.9700 | 1 | 1 |
| Lysyl oxidase homolog 2 | Homo sapiens (human) | IC50 | 0.1500 | 1 | 1 |
| Lysyl oxidase homolog 3 | Homo sapiens (human) | IC50 | 0.0930 | 1 | 1 |
| Lysyl oxidase homolog 4 | Homo sapiens (human) | IC50 | 0.0590 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | IC50 | 9.4250 | 4 | 4 |
| Mitogen-activated protein kinase 3 | Homo sapiens (human) | IC50 | 1.5100 | 1 | 1 |
| Monoglyceride lipase | Homo sapiens (human) | IC50 | 0.8095 | 2 | 2 |
| Mu-type opioid receptor | Homo sapiens (human) | IC50 | 3.5110 | 1 | 1 |
| Mu-type opioid receptor | Homo sapiens (human) | Ki | 1.4250 | 1 | 1 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 117.9750 | 1 | 4 |
| Muscarinic acetylcholine receptor M2 | Rattus norvegicus (Norway rat) | IC50 | 160.0000 | 1 | 1 |
| NACHT, LRR and PYD domains-containing protein 3 | Mus musculus (house mouse) | IC50 | 3.0000 | 1 | 1 |
| Neuraminidase | Influenza A virus (A/USSR/90/1977(H1N1)) | IC50 | 35.3500 | 2 | 2 |
| Neuraminidase | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) | Ki | 14.3000 | 1 | 1 |
| neutrophil cytosol factor 1 | Homo sapiens (human) | IC50 | 0.3900 | 1 | 1 |
| perilipin-1 | Homo sapiens (human) | IC50 | 6.9590 | 1 | 1 |
| perilipin-5 | Homo sapiens (human) | IC50 | 1.6220 | 1 | 1 |
| Phenylethanolamine N-methyltransferase | Bos taurus (cattle) | Ki | 294.0000 | 1 | 1 |
| polyadenylate-binding protein 1 | Homo sapiens (human) | IC50 | 66.0000 | 2 | 2 |
| Polyunsaturated fatty acid lipoxygenase ALOX15 | Oryctolagus cuniculus (rabbit) | IC50 | 16.0660 | 1 | 1 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | IC50 | 185.2210 | 8 | 15 |
| Procathepsin L | Homo sapiens (human) | IC50 | 9.3500 | 1 | 1 |
| Prolyl endopeptidase | Homo sapiens (human) | IC50 | 162.3333 | 2 | 3 |
| Protein-lysine 6-oxidase | Homo sapiens (human) | IC50 | 0.3200 | 1 | 1 |
| Replicase polyprotein 1a | Severe acute respiratory syndrome-related coronavirus | IC50 | 9.3500 | 1 | 1 |
| Replicase polyprotein 1ab | Betacoronavirus England 1 | IC50 | 18.0750 | 2 | 2 |
| Replicase polyprotein 1ab | Human coronavirus 229E | IC50 | 9.3500 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | IC50 | 6.9171 | 9 | 9 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | IC50 | 9.3500 | 2 | 2 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | Ki | 3.7100 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | Ki | 3.7100 | 1 | 1 |
| Retinal dehydrogenase 1 | Homo sapiens (human) | IC50 | 0.1300 | 1 | 1 |
| Sigma non-opioid intracellular receptor 1 | Cavia porcellus (domestic guinea pig) | Ki | 0.0146 | 2 | 2 |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | Ki | 0.0146 | 2 | 2 |
| Small conductance calcium-activated potassium channel protein 3 | Rattus norvegicus (Norway rat) | IC50 | 12.7000 | 1 | 1 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | IC50 | 4.6370 | 1 | 1 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | Ki | 3.6840 | 1 | 1 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | IC50 | 70.3700 | 1 | 1 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | Ki | 69.8120 | 1 | 1 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | IC50 | 500.5000 | 2 | 2 |
| Sodium-dependent serotonin transporter | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 1 |
| Spike glycoprotein | Betacoronavirus England 1 | IC50 | 9.3500 | 1 | 1 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | IC50 | 9.3500 | 1 | 1 |
| Sterol O-acyltransferase 1 | Homo sapiens (human) | IC50 | 0.5000 | 1 | 1 |
| Sterol O-acyltransferase 1 | Rattus norvegicus (Norway rat) | IC50 | 0.5000 | 1 | 1 |
| Telomerase reverse transcriptase | Homo sapiens (human) | IC50 | 37.0000 | 1 | 1 |
| Thioredoxin reductase 1, cytoplasmic | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |
| trace amine-associated receptor 1 | Homo sapiens (human) | IC50 | 0.8818 | 1 | 1 |
| Transmembrane protease serine 2 | Homo sapiens (human) | IC50 | 9.3500 | 1 | 1 |
| type-1 angiotensin II receptor | Homo sapiens (human) | IC50 | 6.6370 | 1 | 1 |
| Tyrosine-protein kinase SYK | Homo sapiens (human) | IC50 | 0.1600 | 1 | 1 |
| Tyrosine-protein phosphatase non-receptor type 1 | Homo sapiens (human) | IC50 | 67.0000 | 1 | 1 |
| Vascular endothelial growth factor receptor 1 | Homo sapiens (human) | IC50 | 0.5900 | 1 | 1 |
| Vascular endothelial growth factor receptor 2 | Homo sapiens (human) | IC50 | 0.5900 | 1 | 1 |
| Vascular endothelial growth factor receptor 3 | Homo sapiens (human) | IC50 | 0.5900 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1C | Homo sapiens (human) | IC50 | 34.3000 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1D | Homo sapiens (human) | IC50 | 34.3000 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1F | Homo sapiens (human) | IC50 | 34.3000 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1S | Homo sapiens (human) | IC50 | 34.3000 | 1 | 1 |