Roles > tubulin modulator
Page last updated: 2024-08-05 15:07:00

tubulin modulator

Any substance that interacts with tubulin to inhibit or promote polymerisation of microtubules.

ChEBI ID: 60832

Members (8)

MemberDefinitionClass
albendazoleA carbamate ester that is methyl 1H-benzimidazol-2-ylcarbamate substituted by a propylsulfanyl group at position 5. It is commonly used in the treatment of parasitic worm infestations.albendazole
benomylA member of the class of benzimidazoles that is the methyl ester of [1-(butylcarbamoyl)-1H-benzimidazol-2-yl]carbamic acid. A foliar fungicide used to control a wide range of Ascomycetes and Fungi Imperfecti in a wide range of crops.benomyl
epothilone aAn epithilone that is epothilone C in which the double bond in the macrocyclic lactone ring has been oxidised to the corresponding epoxide (the 13R,14S diastereoisomer).epothilone A
maytansineAn organic heterotetracyclic compound and 19-membered macrocyclic lactam antibiotic originally isolated from the Ethiopian shrub Maytenus serrata but also found in other Maytenus species. It exhibits cytotoxicity against many tumour cell lines.maytansine
mebendazoleA carbamate ester that is methyl 1H-benzimidazol-2-ylcarbamate substituted by a benzoyl group at position 5.mebendazole
nocodazoleA member of the class of benzimidazoles that is benzimidalole which is substituted at position 2 by a (methoxycarbonyl)amino group and at position 5 by a 2-thienoyl group. It is an antineoplastic agent that exerts its effect by depolymerising microtubules.nocodazole
podophyllotoxinAn organic heterotetracyclic compound that has a furonaphthodioxole skeleton bearing a 3,4,5-trimethoxyphenyl substituent. It is found in the roots and rhizomes of Podophyllum species and is used for the topical treatment of genital warts.podophyllotoxin
vincristineA vinca alkaloid with formula C46H56N4O10 found in the Madagascar periwinkle, Catharanthus roseus. It is used (commonly as the corresponding sulfate salt)as a chemotherapy drug for the treatment of leukaemia, lymphoma, myeloma, breast cancer and head and neck cancer.vincristine

Research

Studies (14,254)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-19902,673 (18.75)18.7374
1990's2,336 (16.39)18.2507
2000's3,934 (27.60)29.6817
2010's4,261 (29.89)24.3611
2020's1,050 (7.37)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials1,190 (7.55%)5.53%
Reviews1,110 (7.04%)6.00%
Case Studies2,274 (14.43%)4.05%
Observational14 (0.09%)0.25%
Other11,173 (70.89%)84.16%

Protein Targets (182)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1Homo sapiens (human)Potency6.309611
67.9K proteinVaccinia virusPotency7.8124210
activating transcription factor 6Homo sapiens (human)Potency13.696814
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency21.925415
alpha-galactosidaseHomo sapiens (human)Potency50.118711
AR proteinHomo sapiens (human)Potency6.60771045
aryl hydrocarbon receptorHomo sapiens (human)Potency13.8546215
arylsulfatase AHomo sapiens (human)Potency23.934111
ATAD5 protein, partialHomo sapiens (human)Potency4.966857
Ataxin-2Homo sapiens (human)Potency8.876618
ATP-dependent phosphofructokinaseTrypanosoma brucei brucei TREU927Potency37.933011
ATPase family AAA domain-containing protein 5Homo sapiens (human)Potency6.6509214
atrial natriuretic peptide receptor 2 precursorHomo sapiens (human)Potency0.232811
Bloom syndrome protein isoform 1Homo sapiens (human)Potency0.002022
caspase 7, apoptosis-related cysteine proteaseHomo sapiens (human)Potency2.357514
caspase-3Homo sapiens (human)Potency2.357514
Cellular tumor antigen p53Homo sapiens (human)Potency5.2718317
cellular tumor antigen p53 isoform aHomo sapiens (human)Potency11.040623
Chain A, Beta-lactamaseEscherichia coli K-12Potency47.717422
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency10.146914
chromobox protein homolog 1Homo sapiens (human)Potency63.252023
CREB-binding proteinHomo sapiens (human)Potency1.194633
cytochrome P450 2C9 precursorHomo sapiens (human)Potency3.595713
cytochrome P450 2C9, partialHomo sapiens (human)Potency5.326613
cytochrome P450 2D6Homo sapiens (human)Potency27.540411
cytochrome P450 3A4 isoform 1Homo sapiens (human)Potency1.995322
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency5.496825
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency25.116816
Disintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)Potency15.848912
DNA dC->dU-editing enzyme APOBEC-3G isoform 1Homo sapiens (human)Potency1.061012
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency11.220211
estrogen nuclear receptor alphaHomo sapiens (human)Potency9.86011046
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency47.189934
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency14.2522838
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency31.021414
EWS/FLI fusion proteinHomo sapiens (human)Potency0.2457413
farnesoid X nuclear receptorHomo sapiens (human)Potency7.3185211
Fumarate hydrataseHomo sapiens (human)Potency5.215715
GVesicular stomatitis virusPotency5.326613
GABA theta subunitRattus norvegicus (Norway rat)Potency1.995311
GALC proteinHomo sapiens (human)Potency0.631011
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)Potency1.995311
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)Potency1.995311
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)Potency1.995311
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)Potency1.995311
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)Potency1.995311
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)Potency1.995311
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)Potency1.995311
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)Potency1.995311
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)Potency1.995311
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)Potency1.995311
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)Potency1.995311
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)Potency1.995311
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)Potency1.995311
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)Potency1.995311
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)Potency1.995311
gemininHomo sapiens (human)Potency0.2500419
GLI family zinc finger 3Homo sapiens (human)Potency5.2507216
glp-1 receptor, partialHomo sapiens (human)Potency3.025822
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency6.4804411
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency15.126916
heat shock protein beta-1Homo sapiens (human)Potency32.181226
Histamine H2 receptorCavia porcellus (domestic guinea pig)Potency3.595719
histone deacetylase 9 isoform 3Homo sapiens (human)Potency14.1404212
Histone H2A.xCricetulus griseus (Chinese hamster)Potency58.990326
HLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)Potency5.326613
huntingtin isoform 2Homo sapiens (human)Potency2.029313
hypoxia-inducible factor 1 alpha subunitHomo sapiens (human)Potency58.158512
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)Homo sapiens (human)Potency1.2334210
IDH1Homo sapiens (human)Potency0.760713
Inositol hexakisphosphate kinase 1Homo sapiens (human)Potency5.326616
Inositol monophosphatase 1Rattus norvegicus (Norway rat)Potency28.183813
Integrin alpha-IIbHomo sapiens (human)Potency12.589311
Integrin beta-3Homo sapiens (human)Potency12.589311
Interferon betaHomo sapiens (human)Potency1.8892318
interleukin 8Homo sapiens (human)Potency47.307911
lamin isoform A-delta10Homo sapiens (human)Potency0.350029
lethal factor (plasmid)Bacillus anthracis str. A2012Potency0.941025
LuciferasePhotinus pyralis (common eastern firefly)Potency17.648038
Microtubule-associated protein tauHomo sapiens (human)Potency19.952611
mitogen-activated protein kinase 1Homo sapiens (human)Potency15.274223
muscleblind-like protein 1 isoform 1Homo sapiens (human)Potency31.622811
neuropeptide S receptor isoform AHomo sapiens (human)Potency13.059412
NFKB1 protein, partialHomo sapiens (human)Potency0.012622
NPC intracellular cholesterol transporter 1 precursorHomo sapiens (human)Potency3.904512
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency4.772039
nuclear factor erythroid 2-related factor 2 isoform 2Homo sapiens (human)Potency7.146314
Nuclear receptor ROR-gammaHomo sapiens (human)Potency23.710111
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency5.008624
nuclear receptor subfamily 1, group I, member 2Rattus norvegicus (Norway rat)Potency1.963314
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency12.8316322
peripheral myelin protein 22Rattus norvegicus (Norway rat)Potency3.415229
peripheral myelin protein 22 isoform 1Homo sapiens (human)Potency26.854511
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency0.632912
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency8.082736
phosphopantetheinyl transferaseBacillus subtilisPotency89.125111
plasminogen precursorMus musculus (house mouse)Potency0.014111
polyproteinZika virusPotency5.215715
potassium voltage-gated channel subfamily H member 2 isoform dHomo sapiens (human)Potency14.125411
PPM1D proteinHomo sapiens (human)Potency0.646718
pregnane X nuclear receptorHomo sapiens (human)Potency16.3783213
pregnane X receptorRattus norvegicus (Norway rat)Potency23.350712
progesterone receptorHomo sapiens (human)Potency13.941527
RAR-related orphan receptor gammaMus musculus (house mouse)Potency8.5318213
ras-related protein Rab-9AHomo sapiens (human)Potency0.112211
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency12.1481324
retinoid X nuclear receptor alphaHomo sapiens (human)Potency6.4544317
serine/threonine-protein kinase mTOR isoform 1Homo sapiens (human)Potency0.119822
SMAD family member 2Homo sapiens (human)Potency23.395824
SMAD family member 3Homo sapiens (human)Potency23.395824
Smad3Homo sapiens (human)Potency0.635112
Spike glycoproteinSevere acute respiratory syndrome-related coronavirusPotency6.309611
survival motor neuron protein isoform dHomo sapiens (human)Potency2.729312
TDP1 proteinHomo sapiens (human)Potency0.1995234
thioredoxin reductaseRattus norvegicus (Norway rat)Potency79.432811
ThrombopoietinHomo sapiens (human)Potency0.012622
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency2.2182218
thyroid stimulating hormone receptorHomo sapiens (human)Potency21.569146
transcriptional regulator ERG isoform 3Homo sapiens (human)Potency50.118711
ubiquitin carboxyl-terminal hydrolase 2 isoform aHomo sapiens (human)Potency15.848912
urokinase plasminogen activator surface receptor precursorMus musculus (house mouse)Potency0.014111
urokinase-type plasminogen activator precursorMus musculus (house mouse)Potency0.014111
USP1 protein, partialHomo sapiens (human)Potency35.716822
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency7.9390214
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency8.706637
Voltage-dependent calcium channel gamma-2 subunitMus musculus (house mouse)Potency15.126916

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
5-hydroxytryptamine receptor 2BHomo sapiens (human)IC5020.180011
5-hydroxytryptamine receptor 2BHomo sapiens (human)Ki12.845011
Adenosine receptor A1Homo sapiens (human)IC5050.330011
Adenosine receptor A1Homo sapiens (human)Ki29.433011
Adenosine receptor A2aHomo sapiens (human)IC507.509011
Adenosine receptor A2aHomo sapiens (human)Ki4.219011
Amine oxidase [flavin-containing] AHomo sapiens (human)IC5024.099011
ATP-binding cassette sub-family C member 3Homo sapiens (human)IC50133.000012
ATP-dependent translocase ABCB1Homo sapiens (human)Ki213.000011
Beta-tubulin Leishmania donovaniIC501.000011
Bile salt export pumpHomo sapiens (human)IC50133.000012
Calcium-activated potassium channel subunit alpha-1Rattus norvegicus (Norway rat)IC500.560011
Calmodulin-domain protein kinase 1Toxoplasma gondiiIC500.670011
Canalicular multispecific organic anion transporter 1Homo sapiens (human)IC50133.000012
Canalicular multispecific organic anion transporter 1Homo sapiens (human)Ki802.000011
Chain A, Glutathione-requiring prostaglandin D synthaseHomo sapiens (human)IC5065.000011
Cytochrome P450 2C19Homo sapiens (human)IC505.000011
Cytochrome P450 2C9 Homo sapiens (human)IC504.000011
Cytochrome P450 3A4Homo sapiens (human)IC500.600011
Fatty-acid amide hydrolase 1Rattus norvegicus (Norway rat)IC5010.000012
Glucocorticoid receptorHomo sapiens (human)IC500.014011
Methionine aminopeptidaseEscherichia coli K-12IC5010.000012
Multidrug resistance-associated protein 1 Homo sapiens (human)IC5070.000011
Multidrug resistance-associated protein 4Homo sapiens (human)IC5074.250012
nuclear receptor subfamily 0 group B member 1Homo sapiens (human)IC501.489212
Prostaglandin G/H synthase 1Ovis aries (sheep)IC5018.000023
Prostaglandin G/H synthase 2Mus musculus (house mouse)IC5018.000023
Proto-oncogene tyrosine-protein kinase SrcHomo sapiens (human)IC5010.000011
Proto-oncogene tyrosine-protein kinase SrcHomo sapiens (human)Ki10.000011
Similar to alpha-tubulin isoform 1 Bos taurus (cattle)IC501.05391223
Sodium-dependent dopamine transporter Homo sapiens (human)IC506.232011
Sodium-dependent dopamine transporter Homo sapiens (human)Ki4.946011
Solute carrier organic anion transporter family member 1B1Homo sapiens (human)IC5044.000011
Solute carrier organic anion transporter family member 1B1Homo sapiens (human)Ki42.000011
Solute carrier organic anion transporter family member 1B3Homo sapiens (human)IC5023.890022
Solute carrier organic anion transporter family member 1B3Homo sapiens (human)Ki13.700022
steroidogenic factor 1Homo sapiens (human)IC5067.523512
Tubulin alpha-1A chainHomo sapiens (human)IC5039.66921012
Tubulin alpha-1A chainSus scrofa (pig)IC500.95501320
Tubulin alpha-1A chainSus scrofa (pig)Ki2.180011
Tubulin alpha-1B chainHomo sapiens (human)IC5039.66921012
Tubulin alpha-1C chainHomo sapiens (human)IC5039.66921012
Tubulin alpha-3C chainHomo sapiens (human)IC5039.66921012
Tubulin alpha-3E chainHomo sapiens (human)IC5039.66921012
Tubulin alpha-4A chainHomo sapiens (human)IC5039.66921012
Tubulin beta chainHomo sapiens (human)IC5039.66921012
Tubulin beta chainSus scrofa (pig)IC500.67881017
Tubulin beta chainSus scrofa (pig)Ki2.180011
Tubulin beta-1 chainHomo sapiens (human)IC5039.66921012
Tubulin beta-2A chainHomo sapiens (human)IC5039.66921012
Tubulin beta-2B chainBos taurus (cattle)IC501.02601515
Tubulin beta-2B chainHomo sapiens (human)IC5039.66921012
Tubulin beta-3 chainHomo sapiens (human)IC5039.66921012
Tubulin beta-4A chainHomo sapiens (human)IC5039.66921012
Tubulin beta-4B chainHomo sapiens (human)IC5039.66921012
Tubulin beta-6 chainHomo sapiens (human)IC5039.66921012
Tubulin beta-8 chainHomo sapiens (human)IC5039.66921012
Tyrosine-protein kinase ABL1Homo sapiens (human)IC502.820022
Tyrosine-protein kinase ABL1Homo sapiens (human)Ki4.600011
Vascular endothelial growth factor receptor 2Homo sapiens (human)IC505.566733

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Regulatory protein E2human papillomavirus 11Kd20.100011
Regulatory protein E2Human papillomavirus 16Kd70.500011
Regulatory protein E2Human papillomavirus type 1aKd206.287544
Tubulin alpha-1A chainHomo sapiens (human)EC500.900011
Tubulin alpha-1A chainHomo sapiens (human)Kd21.500011
Tubulin alpha-1A chainSus scrofa (pig)Kd70.500011
Tubulin alpha-1B chainHomo sapiens (human)EC500.900011
Tubulin alpha-1B chainHomo sapiens (human)Kd21.500011
Tubulin alpha-1C chainHomo sapiens (human)EC500.900011
Tubulin alpha-1C chainHomo sapiens (human)Kd21.500011
Tubulin alpha-3C chainHomo sapiens (human)EC500.900011
Tubulin alpha-3C chainHomo sapiens (human)Kd21.500011
Tubulin alpha-3E chainHomo sapiens (human)EC500.900011
Tubulin alpha-3E chainHomo sapiens (human)Kd21.500011
Tubulin alpha-4A chainHomo sapiens (human)EC500.900011
Tubulin alpha-4A chainHomo sapiens (human)Kd21.500011
Tubulin beta chainHomo sapiens (human)EC500.900011
Tubulin beta chainHomo sapiens (human)Kd21.500011
Tubulin beta chainSus scrofa (pig)Kd70.500011
Tubulin beta-1 chainHomo sapiens (human)EC500.900011
Tubulin beta-1 chainHomo sapiens (human)Kd21.500011
Tubulin beta-2A chainHomo sapiens (human)EC500.900011
Tubulin beta-2A chainHomo sapiens (human)Kd21.500011
Tubulin beta-2B chainHomo sapiens (human)EC500.900011
Tubulin beta-2B chainHomo sapiens (human)Kd21.500011
Tubulin beta-3 chainHomo sapiens (human)EC500.900011
Tubulin beta-3 chainHomo sapiens (human)Kd21.500011
Tubulin beta-4A chainHomo sapiens (human)EC500.900011
Tubulin beta-4A chainHomo sapiens (human)Kd21.500011
Tubulin beta-4B chainHomo sapiens (human)EC500.900011
Tubulin beta-4B chainHomo sapiens (human)Kd21.500011
Tubulin beta-6 chainHomo sapiens (human)EC500.900011
Tubulin beta-6 chainHomo sapiens (human)Kd21.500011
Tubulin beta-8 chainHomo sapiens (human)EC500.900011
Tubulin beta-8 chainHomo sapiens (human)Kd21.500011

Other Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
ATP-dependent translocase ABCB1Homo sapiens (human)Ki10.470011
ATP-dependent translocase ABCB1Homo sapiens (human)Ki2148.000011
PAX8Homo sapiens (human)AC500.260011
Similar to alpha-tubulin isoform 1 Bos taurus (cattle)INH2.200012
Tubulin alpha-1A chainHomo sapiens (human)Activity23.500011
Tubulin alpha-1B chainHomo sapiens (human)Activity23.500011
Tubulin alpha-1C chainHomo sapiens (human)Activity23.500011
Tubulin alpha-3C chainHomo sapiens (human)Activity23.500011
Tubulin alpha-3E chainHomo sapiens (human)Activity23.500011
Tubulin alpha-4A chainHomo sapiens (human)Activity23.500011
Tubulin beta chainHomo sapiens (human)Activity23.500011
Tubulin beta-1 chainHomo sapiens (human)Activity23.500011
Tubulin beta-2A chainHomo sapiens (human)Activity23.500011
Tubulin beta-2B chainHomo sapiens (human)Activity23.500011
Tubulin beta-2B chainBos taurus (cattle)INH2.200011
Tubulin beta-3 chainHomo sapiens (human)Activity23.500011
Tubulin beta-4A chainHomo sapiens (human)Activity23.500011
Tubulin beta-4B chainHomo sapiens (human)Activity23.500011
Tubulin beta-6 chainHomo sapiens (human)Activity23.500011
Tubulin beta-8 chainHomo sapiens (human)Activity23.500011
VifHuman immunodeficiency virus 1AC5015.370011
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