Any substance that interacts with tubulin to inhibit or promote polymerisation of microtubules.
| Member | Definition | Class |
|---|
| albendazole | A carbamate ester that is methyl 1H-benzimidazol-2-ylcarbamate substituted by a propylsulfanyl group at position 5. It is commonly used in the treatment of parasitic worm infestations. | albendazole |
| benomyl | A member of the class of benzimidazoles that is the methyl ester of [1-(butylcarbamoyl)-1H-benzimidazol-2-yl]carbamic acid. A foliar fungicide used to control a wide range of Ascomycetes and Fungi Imperfecti in a wide range of crops. | benomyl |
| epothilone a | An epithilone that is epothilone C in which the double bond in the macrocyclic lactone ring has been oxidised to the corresponding epoxide (the 13R,14S diastereoisomer). | epothilone A |
| maytansine | An organic heterotetracyclic compound and 19-membered macrocyclic lactam antibiotic originally isolated from the Ethiopian shrub Maytenus serrata but also found in other Maytenus species. It exhibits cytotoxicity against many tumour cell lines. | maytansine |
| mebendazole | A carbamate ester that is methyl 1H-benzimidazol-2-ylcarbamate substituted by a benzoyl group at position 5. | mebendazole |
| nocodazole | A member of the class of benzimidazoles that is benzimidalole which is substituted at position 2 by a (methoxycarbonyl)amino group and at position 5 by a 2-thienoyl group. It is an antineoplastic agent that exerts its effect by depolymerising microtubules. | nocodazole |
| podophyllotoxin | An organic heterotetracyclic compound that has a furonaphthodioxole skeleton bearing a 3,4,5-trimethoxyphenyl substituent. It is found in the roots and rhizomes of Podophyllum species and is used for the topical treatment of genital warts. | podophyllotoxin |
| vincristine | A vinca alkaloid with formula C46H56N4O10 found in the Madagascar periwinkle, Catharanthus roseus. It is used (commonly as the corresponding sulfate salt)as a chemotherapy drug for the treatment of leukaemia, lymphoma, myeloma, breast cancer and head and neck cancer. | vincristine |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 6.3096 | 1 | 1 |
| 67.9K protein | Vaccinia virus | Potency | 7.8124 | 2 | 10 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 13.6968 | 1 | 4 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 21.9254 | 1 | 5 |
| alpha-galactosidase | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 6.6077 | 10 | 45 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 13.8546 | 2 | 15 |
| arylsulfatase A | Homo sapiens (human) | Potency | 23.9341 | 1 | 1 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 4.9668 | 5 | 7 |
| Ataxin-2 | Homo sapiens (human) | Potency | 8.8766 | 1 | 8 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 37.9330 | 1 | 1 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 6.6509 | 2 | 14 |
| atrial natriuretic peptide receptor 2 precursor | Homo sapiens (human) | Potency | 0.2328 | 1 | 1 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 0.0020 | 2 | 2 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 2.3575 | 1 | 4 |
| caspase-3 | Homo sapiens (human) | Potency | 2.3575 | 1 | 4 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 5.2718 | 3 | 17 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 11.0406 | 2 | 3 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 47.7174 | 2 | 2 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 10.1469 | 1 | 4 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 63.2520 | 2 | 3 |
| CREB-binding protein | Homo sapiens (human) | Potency | 1.1946 | 3 | 3 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 3.5957 | 1 | 3 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 5.3266 | 1 | 3 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 27.5404 | 1 | 1 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 1.9953 | 2 | 2 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 5.4968 | 2 | 5 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 25.1168 | 1 | 6 |
| Disintegrin and metalloproteinase domain-containing protein 17 | Homo sapiens (human) | Potency | 15.8489 | 1 | 2 |
| DNA dC->dU-editing enzyme APOBEC-3G isoform 1 | Homo sapiens (human) | Potency | 1.0610 | 1 | 2 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 9.8601 | 10 | 46 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 47.1899 | 3 | 4 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 14.2522 | 8 | 38 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 31.0214 | 1 | 4 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 0.2457 | 4 | 13 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 7.3185 | 2 | 11 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 5.2157 | 1 | 5 |
| G | Vesicular stomatitis virus | Potency | 5.3266 | 1 | 3 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 1.9953 | 1 | 1 |
| GALC protein | Homo sapiens (human) | Potency | 0.6310 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 1.9953 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 1.9953 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 1.9953 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 1.9953 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 1.9953 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 1.9953 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 1.9953 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 1.9953 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 1.9953 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 1.9953 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 1.9953 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 1.9953 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 1.9953 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 1.9953 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 1.9953 | 1 | 1 |
| geminin | Homo sapiens (human) | Potency | 0.2500 | 4 | 19 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 5.2507 | 2 | 16 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 3.0258 | 2 | 2 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 6.4804 | 4 | 11 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 15.1269 | 1 | 6 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 32.1812 | 2 | 6 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 3.5957 | 1 | 9 |
| histone deacetylase 9 isoform 3 | Homo sapiens (human) | Potency | 14.1404 | 2 | 12 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 58.9903 | 2 | 6 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 5.3266 | 1 | 3 |
| huntingtin isoform 2 | Homo sapiens (human) | Potency | 2.0293 | 1 | 3 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 58.1585 | 1 | 2 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 1.2334 | 2 | 10 |
| IDH1 | Homo sapiens (human) | Potency | 0.7607 | 1 | 3 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 5.3266 | 1 | 6 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 28.1838 | 1 | 3 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| Interferon beta | Homo sapiens (human) | Potency | 1.8892 | 3 | 18 |
| interleukin 8 | Homo sapiens (human) | Potency | 47.3079 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 0.3500 | 2 | 9 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 0.9410 | 2 | 5 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 17.6480 | 3 | 8 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 15.2742 | 2 | 3 |
| muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 13.0594 | 1 | 2 |
| NFKB1 protein, partial | Homo sapiens (human) | Potency | 0.0126 | 2 | 2 |
| NPC intracellular cholesterol transporter 1 precursor | Homo sapiens (human) | Potency | 3.9045 | 1 | 2 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 4.7720 | 3 | 9 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 7.1463 | 1 | 4 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 23.7101 | 1 | 1 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 5.0086 | 2 | 4 |
| nuclear receptor subfamily 1, group I, member 2 | Rattus norvegicus (Norway rat) | Potency | 1.9633 | 1 | 4 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 12.8316 | 3 | 22 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 3.4152 | 2 | 9 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 26.8545 | 1 | 1 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 0.6329 | 1 | 2 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 8.0827 | 3 | 6 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 89.1251 | 1 | 1 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 0.0141 | 1 | 1 |
| polyprotein | Zika virus | Potency | 5.2157 | 1 | 5 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 14.1254 | 1 | 1 |
| PPM1D protein | Homo sapiens (human) | Potency | 0.6467 | 1 | 8 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 16.3783 | 2 | 13 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 23.3507 | 1 | 2 |
| progesterone receptor | Homo sapiens (human) | Potency | 13.9415 | 2 | 7 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 8.5318 | 2 | 13 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 0.1122 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 12.1481 | 3 | 24 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 6.4544 | 3 | 17 |
| serine/threonine-protein kinase mTOR isoform 1 | Homo sapiens (human) | Potency | 0.1198 | 2 | 2 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 23.3958 | 2 | 4 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 23.3958 | 2 | 4 |
| Smad3 | Homo sapiens (human) | Potency | 0.6351 | 1 | 2 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 6.3096 | 1 | 1 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 2.7293 | 1 | 2 |
| TDP1 protein | Homo sapiens (human) | Potency | 0.1995 | 2 | 34 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 79.4328 | 1 | 1 |
| Thrombopoietin | Homo sapiens (human) | Potency | 0.0126 | 2 | 2 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 2.2182 | 2 | 18 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 21.5691 | 4 | 6 |
| transcriptional regulator ERG isoform 3 | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| ubiquitin carboxyl-terminal hydrolase 2 isoform a | Homo sapiens (human) | Potency | 15.8489 | 1 | 2 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 0.0141 | 1 | 1 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 0.0141 | 1 | 1 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 35.7168 | 2 | 2 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 7.9390 | 2 | 14 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 8.7066 | 3 | 7 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 15.1269 | 1 | 6 |