Roles > enzyme inhibitor
Page last updated: 2024-08-05 15:24:11

enzyme inhibitor

A compound or agent that combines with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.

ChEBI ID: 23924

Members (3)

MemberDefinitionClass
acetyldigitoxinA cardenolide glycoside compound consisting of digitoxin having an acetyl substituent at the 3-position on the D-ribo-hexopyranosyl residue at the non-reducing end.3'''-O-acetyldigitoxin
erythromycin estolateerythromycin estolate
oxolinic acidA quinolinemonocarboxylic acid having the carboxy group at position 7 as well as oxo and ethyl groups at positions 4 and 1 respectively and a dioxolo ring fused at the 5- and 6-positions. A synthetic antibiotic, it is used in veterinary medicine for the treatment of bacterial infections in cattle, pigs and poultry.oxolinic acid

Research

Studies (674)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-1990430 (63.80)18.7374
1990's87 (12.91)18.2507
2000's79 (11.72)29.6817
2010's58 (8.61)24.3611
2020's20 (2.97)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials45 (6.11%)5.53%
Reviews26 (3.53%)6.00%
Case Studies28 (3.80%)4.05%
Observational0 (0.00%)0.25%
Other638 (86.57%)84.16%

Protein Targets (48)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1Homo sapiens (human)Potency19.952611
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency17.782811
AR proteinHomo sapiens (human)Potency55.259311
arylsulfatase AHomo sapiens (human)Potency21.331311
ATP-dependent phosphofructokinaseTrypanosoma brucei brucei TREU927Potency37.933011
caspase 7, apoptosis-related cysteine proteaseHomo sapiens (human)Potency45.456211
caspase-3Homo sapiens (human)Potency45.456211
Cellular tumor antigen p53Homo sapiens (human)Potency45.456222
Chain A, 2-oxoglutarate OxygenaseHomo sapiens (human)Potency25.118911
Chain A, Ferritin light chainEquus caballus (horse)Potency28.183811
Chain A, HADH2 proteinHomo sapiens (human)Potency25.118911
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency39.810711
Chain A, TYROSYL-DNA PHOSPHODIESTERASEHomo sapiens (human)Potency1.995311
Chain B, HADH2 proteinHomo sapiens (human)Potency25.118911
chromobox protein homolog 1Homo sapiens (human)Potency0.006711
cytochrome P450 2D6 isoform 1Homo sapiens (human)Potency10.000011
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency36.107111
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency44.668411
estrogen nuclear receptor alphaHomo sapiens (human)Potency31.154922
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency78.055811
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency6.230312
GLI family zinc finger 3Homo sapiens (human)Potency15.573824
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency32.460511
heat shock protein beta-1Homo sapiens (human)Potency36.421322
histone acetyltransferase KAT2A isoform 1Homo sapiens (human)Potency15.848911
Histone H2A.xCricetulus griseus (Chinese hamster)Potency74.914311
hypoxia-inducible factor 1 alpha subunitHomo sapiens (human)Potency18.395312
Inositol monophosphatase 1Rattus norvegicus (Norway rat)Potency7.943311
LuciferasePhotinus pyralis (common eastern firefly)Potency52.810411
muscarinic acetylcholine receptor M1Rattus norvegicus (Norway rat)Potency0.017811
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency36.266422
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_aHomo sapiens (human)Potency36.421311
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency36.421311
pregnane X nuclear receptorHomo sapiens (human)Potency9.069711
progesterone receptorHomo sapiens (human)Potency1.237111
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency40.512911
SMAD family member 2Homo sapiens (human)Potency10.409411
SMAD family member 3Homo sapiens (human)Potency10.409411
TDP1 proteinHomo sapiens (human)Potency29.092911
thioredoxin reductaseRattus norvegicus (Norway rat)Potency14.222133
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency36.813422
thyroid stimulating hormone receptorHomo sapiens (human)Potency27.443722
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency24.364622
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency32.460511

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Bile salt export pumpHomo sapiens (human)IC5010.033333
Bile salt export pumpRattus norvegicus (Norway rat)IC5011.400011
Solute carrier organic anion transporter family member 1B1Homo sapiens (human)IC504.365211
Solute carrier organic anion transporter family member 1B1Homo sapiens (human)Ki2.410011
Solute carrier organic anion transporter family member 1B3Homo sapiens (human)IC503.090311
Solute carrier organic anion transporter family member 1B3Homo sapiens (human)Ki2.350011