Any protease inhibitor that restricts the action of a cysteine protease.
ChEBI ID: 64152
| Member | Definition | Class |
|---|---|---|
| acetylleucyl-leucyl-norleucinal | A tripeptide composed of N-acetylleucyl, leucyl and norleucinal residues joined in sequence. | acetylleucyl-leucyl-norleucinal |
| berkeleydione | A meroterpenoid found in Penicillium rubrum. It has been shown to exhibit inhibitory activity against caspase-1. | berkeleydione |
| berkeleytrione | A meroterpenoid found in Penicillium rubrum and has been shown to exhibit inhibitory activity against caspase-1. | berkeleytrione |
| cathestatin b | A carboxamide obtained by the formal condensation of the carboxylic group of oxirane-2,3-dicarboxylic acid with the amino group of N-(4-aminobutyl)-L-tyrosinamide (the 2S,3S stereoisomer). An antibiotic isolated from the fermentation broth of Penicillium citrinum, it acts as a potent inhibitor of cysteine protease. | cathestatin B |
| cryptolepine | An organic heterotetracyclic compound that is 5H-indolo[3,2-b]quinoline in which the hydrogen at position N-5 is replaced by a methyl group. | cryptolepine |
| geldanamycin | An ansamycin consisting of a 19-membered macrocyle incorporating a benzoquinone ring and a lactam functionality. It shows antimicrobial activity against many Gram-positive and some Gram-negative bacteria. | geldanamycin |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 12 (2.25) | 18.7374 |
| 1990's | 139 (26.03) | 18.2507 |
| 2000's | 196 (36.70) | 29.6817 |
| 2010's | 146 (27.34) | 24.3611 |
| 2020's | 41 (7.68) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 1 (0.18%) | 5.53% |
| Reviews | 17 (3.06%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 537 (96.76%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 8.0330 | 5 | 5 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 0.0032 | 2 | 2 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 3.5397 | 1 | 1 |
| heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 0.5012 | 1 | 1 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 3.3528 | 1 | 2 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 1.1938 | 2 | 2 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 79.4328 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| ATP-dependent molecular chaperone HSP82 | Saccharomyces cerevisiae S288C | IC50 | 3.9667 | 2 | 3 |
| Breakpoint cluster region protein | Homo sapiens (human) | IC50 | 3.0000 | 2 | 2 |
| Calpain small subunit 1 | Homo sapiens (human) | IC50 | 7.0000 | 1 | 1 |
| Calpain-1 catalytic subunit | Homo sapiens (human) | IC50 | 4.0000 | 2 | 2 |
| Calpain-1 catalytic subunit | Sus scrofa (pig) | Ki | 0.1900 | 1 | 1 |
| Cathepsin B | Homo sapiens (human) | Ki | 0.1500 | 1 | 1 |
| Cytochrome P450 1A2 | Homo sapiens (human) | IC50 | 0.0140 | 1 | 1 |
| Cytochrome P450 2C19 | Homo sapiens (human) | IC50 | 0.0740 | 1 | 1 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 0.0740 | 1 | 1 |
| Cytochrome P450 2D6 | Homo sapiens (human) | IC50 | 0.0140 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 0.0140 | 1 | 1 |
| Cytochrome P450 3A43 | Homo sapiens (human) | IC50 | 0.0140 | 1 | 1 |
| Cytochrome P450 3A5 | Homo sapiens (human) | IC50 | 0.0140 | 1 | 1 |
| Cytochrome P450 3A7 | Homo sapiens (human) | IC50 | 0.0140 | 1 | 1 |
| Endoplasmin | Canis lupus familiaris (dog) | IC50 | 0.0100 | 1 | 1 |
| Heat shock protein 75 kDa, mitochondrial | Homo sapiens (human) | IC50 | 0.6610 | 1 | 1 |
| Heat shock protein HSP 90 | Oryctolagus cuniculus (rabbit) | IC50 | 1.1410 | 2 | 2 |
| Heat shock protein HSP 90-alpha | Homo sapiens (human) | IC50 | 0.0917 | 20 | 20 |
| Heat shock protein HSP 90-beta | Homo sapiens (human) | IC50 | 0.0980 | 7 | 7 |
| Interleukin-1 beta | Homo sapiens (human) | IC50 | 4.4000 | 1 | 1 |
| Lysine-specific demethylase 4B | Homo sapiens (human) | IC50 | 0.7000 | 1 | 1 |
| Lysine-specific demethylase 4C | Homo sapiens (human) | IC50 | 0.7000 | 1 | 1 |
| Lysine-specific demethylase 5A | Homo sapiens (human) | IC50 | 0.1300 | 1 | 1 |
| Lysine-specific demethylase 6B | Homo sapiens (human) | IC50 | 0.4000 | 1 | 1 |
| Putative heat shock protein HSP 90-alpha A4 | Homo sapiens (human) | IC50 | 0.1400 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | IC50 | 8.5967 | 2 | 3 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | IC50 | 8.6000 | 1 | 1 |
| Telomerase reverse transcriptase | Homo sapiens (human) | IC50 | 9.4000 | 3 | 3 |
| Tyrosine-protein kinase ABL1 | Homo sapiens (human) | IC50 | 3.0000 | 2 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| ATP-dependent molecular chaperone HSP82 | Saccharomyces cerevisiae S288C | Kd | 1.2000 | 1 | 1 |
| Heat shock protein 90, putative | Plasmodium falciparum 3D7 | Kd | 0.2435 | 2 | 2 |
| Heat shock protein HSP 90-alpha | Homo sapiens (human) | EC50 | 0.0350 | 1 | 1 |
| Heat shock protein HSP 90-alpha | Homo sapiens (human) | Kd | 1.0208 | 5 | 5 |
| Heat shock protein HSP 90-beta | Homo sapiens (human) | EC50 | 0.0350 | 1 | 1 |
| Heat shock protein HSP 90-beta | Homo sapiens (human) | Kd | 0.7300 | 6 | 6 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | Km | 100.0000 | 1 | 1 |
| DNA topoisomerase 2-beta | Homo sapiens (human) | MIC | 0.2500 | 1 | 1 |
| Heat shock protein HSP 90-alpha | Homo sapiens (human) | Concentration | 5.0000 | 1 | 1 |
| Heat shock protein HSP 90-beta | Homo sapiens (human) | Activity | 0.1655 | 2 | 2 |
| Tissue factor | Homo sapiens (human) | Concentration | 5.0000 | 1 | 1 |