Compounds > 6-amino-1,3-dimethyl uracil
Page last updated: 2024-11-06

6-amino-1,3-dimethyl uracil

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

6-amino-1,3-dimethyl uracil, also known as 6-amino-1,3-dimethyluracil, is a synthetic derivative of uracil. Its synthesis typically involves methylation of the uracil base at the N1 and N3 positions followed by an amino group substitution at the C6 position. Research on this compound is driven by its potential applications in various fields, including medicine, agriculture, and materials science. Studies have shown that 6-amino-1,3-dimethyl uracil exhibits significant biological activity. It has been reported to possess anticancer properties, acting as an inhibitor of certain enzymes involved in cell growth and proliferation. In addition, 6-amino-1,3-dimethyl uracil has been investigated for its potential to modulate the immune system. Due to its unique structural features, 6-amino-1,3-dimethyl uracil has also been explored for its potential use in developing novel materials with specific properties. Further research is ongoing to fully understand the pharmacological and other potential applications of this compound.'

6-amino-1,3-dimethyl uracil: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID81152
SCHEMBL ID23857
MeSH IDM0457963

Synonyms (53)

Synonym
HMS1760O20
AB-323/25048015
6-amino-1,3-dimethylpyrimidine-2,4(1h,3h)-dione
nsc15492
6642-31-5
nsc-15492
1,3-dimethyl-6-amino-uracil
6-amino-1,3-dimethyluracil
2,3h)-pyrimidinedione, 6-amino-1,3-dimethyl-
4-amino-1,3-dimethyl-2,6-dihydroxypyrimidine
6-amino-1,3-dimethyluracil, 98%
6-amino-1,3-dimethyl-2,4(1h,3h)-pyrimidinedione
uracil, 6-amino-1,3-dimethyl-
einecs 229-662-0
nsc 15492
ai3-52449
brn 0144390
2,4(1h,3h)-pyrimidinedione, 6-amino-1,3-dimethyl-
OPREA1_258982
6-amino-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
6-amino-1,3-dimethylpyrimidine-2,4-dione
AKOS000119420
A835462
6-azanyl-1,3-dimethyl-pyrimidine-2,4-dione
STK711155
6-amino-1,3-dimethyluracil inverted exclamation mark cent6-amino-1,3-dimethyl-2,4(1h,3h)-dione
ec 229-662-0
6-amino-1,3-dimethyl uracil
5-25-15-00389 (beilstein handbook reference)
AKOS015923159
FT-0620900
SCHEMBL23857
6-amino-1,3-dimethyl-1h-pyrimidine-2,4-dione
6-amino-1,3-dimethyl-2,4-dioxopyrimidine
1.3-dimethyl-6-aminouracil
6-amino-n,n'-dimethyluracil
1,3-dimethyl-6-aminouracil
6-amino-1,3-dimethyl-2,4(1h,3h)-pyrimidinedione #
4-amino-1,3-dimethyluracil
1,3-dimethyl-4-amino-5-formamido-uracil
W-104749
DTXSID4074350
F3055-0304
CS-W002006
mfcd00006552
AC-2046
Z56931829
SY032905
AS-13106
AMY21858
EN300-17430
6-amino-1,3-di methyluracil 100 microg/ml in acetonitrile
SB57729
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (2)

Assay IDTitleYearJournalArticle
AID588519A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities2011Antiviral research, Sep, Volume: 91, Issue:3
High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
AID540299A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis2010Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (12.50)29.6817
2010's4 (50.00)24.3611
2020's3 (37.50)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
pyruvic acid
Pyruvic Acid: An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed). pyruvic acid : A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis.		2.31102-oxo monocarboxylic acidcofactor;
fundamental metabolite
uracil
2,4-dihydroxypyrimidine: a urinary biomarker for bipolar disorder		8.3660pyrimidine nucleobase;
pyrimidone		allergen;
Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
prodrug;
Saccharomyces cerevisiae metabolite
cyclohexanone
[no description available]		7.0110cyclohexanoneshuman xenobiotic metabolite
cadmium oxide
cadmium oxide: causes severe lung damage; RN given refers to parent cpd		2.3110
zirconium
Zirconium: A rather rare metallic element with atomic number 40, atomic weight 91.224, and symbol Zr.		2.0810titanium group element atom
tiletamine hydrochloride
Cyclohexanones: Cyclohexane ring substituted by one or more ketones in any position.. cyclohexanones : Any alicyclic ketone based on a cyclohexane skeleton and its substituted derivatives thereof.		2.0110
organophosphonates
hydrogenphosphite : A divalent inorganic anion resulting from the removal of a proton from two of the hydroxy groups of phosphorous acid.		2.2510divalent inorganic anion;
phosphite ion
1,1-diphenyl-2-picrylhydrazyl
1,1-diphenyl-2-picrylhydrazyl: A diphenyl picrate; the ability to decolorize this stable radical indicates reactivity of tested compounds (Banda, Anal Chem 46:1772-7 1974)		2.2510
ascorbic acid
Ascorbic Acid: A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.. L-ascorbic acid : The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate.. L-ascorbate : The L-enantiomer of ascorbate and conjugate base of L-ascorbic acid, arising from selective deprotonation of the 3-hydroxy group. Required for a range of essential metabolic reactions in all animals and plants.. vitamin C : Any member of a group of vitamers that belong to the chemical structural class called butenolides that exhibit biological activity against vitamin C deficiency in animals. The vitamers include L-ascorbic acid and its salt, ionized and oxidized forms.		2.2510ascorbic acid;
vitamin C		coenzyme;
cofactor;
flour treatment agent;
food antioxidant;
food colour retention agent;
geroprotector;
plant metabolite;
skin lightening agent
warfarin
Warfarin: An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.. warfarin : A racemate comprising equal amounts of (R)- and (S)-warfarin. Extensively used as both an anticoagulant drug and as a pesticide against rats and mice.. 4-hydroxy-3-(3-oxo-1-phenylbutyl)-1-benzopyran-2-one : A member of the class of coumarins that is 4-hydroxycoumarin which is substituted at position 3 by a 1-phenyl-3-oxo-1-butyl group.		2.0510benzenes;
hydroxycoumarin;
methyl ketone
pyrimidinones
Pyrimidinones: Heterocyclic compounds known as 2-pyrimidones (or 2-hydroxypyrimidines) and 4-pyrimidones (or 4-hydroxypyrimidines) with the general formula C4H4N2O.		2.0510
ConditionIndicatedRelationship StrengthStudiesTrials
Encephalitis, Polio
[description not available]		02.0610
Poliomyelitis
An acute infectious disease of humans, particularly children, caused by any of three serotypes of human poliovirus (POLIOVIRUS). Usually the infection is limited to the gastrointestinal tract and nasopharynx, and is often asymptomatic. The central nervous system, primarily the spinal cord, may be affected, leading to rapidly progressive paralysis, coarse FASCICULATION and hyporeflexia. Motor neurons are primarily affected. Encephalitis may also occur. The virus replicates in the nervous system, and may cause significant neuronal loss, most notably in the spinal cord. A rare related condition, nonpoliovirus poliomyelitis, may result from infections with nonpoliovirus enteroviruses. (From Adams et al., Principles of Neurology, 6th ed, pp764-5)		02.0610