An EC 3.4.24.* (metalloendopeptidase) inhibitor that interferes with the action of endothelin-converting enzyme 1 (EC 3.4.24.71).
ChEBI ID: 82974
| Member | Definition | Class |
|---|---|---|
| phosphoramidon | A dipeptide isolated from the cultures of Streptomyces tanashiensis. | phosphoramidon |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 101 (13.29) | 18.7374 |
| 1990's | 476 (62.63) | 18.2507 |
| 2000's | 142 (18.68) | 29.6817 |
| 2010's | 39 (5.13) | 24.3611 |
| 2020's | 2 (0.26) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 12 (1.54%) | 5.53% |
| Reviews | 10 (1.28%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 759 (97.18%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Angiotensin-converting enzyme | Homo sapiens (human) | IC50 | 0.6150 | 2 | 2 |
| Chain E, Thermolysin | Bacillus thermoproteolyticus | Ki | 0.0280 | 1 | 2 |
| EEF1AKMT4-ECE2 readthrough transcript protein | Homo sapiens (human) | Ki | 0.0012 | 1 | 1 |
| Endothelin-converting enzyme 1 | Homo sapiens (human) | IC50 | 1.0695 | 6 | 6 |
| Neprilysin | Homo sapiens (human) | IC50 | 0.0405 | 4 | 4 |
| Neprilysin | Oryctolagus cuniculus (rabbit) | IC50 | 0.0028 | 3 | 3 |
| Neprilysin | Rattus norvegicus (Norway rat) | IC50 | 0.0578 | 6 | 6 |
| Neprilysin | Rattus norvegicus (Norway rat) | Ki | 0.0040 | 1 | 1 |
| P2Y purinoceptor 12 | Homo sapiens (human) | IC50 | 0.0170 | 1 | 1 |
| Thermolysin | Bacillus thermoproteolyticus | IC50 | 0.0330 | 1 | 1 |
| Thermolysin | Bacillus thermoproteolyticus | Ki | 0.0280 | 1 | 1 |