Familial Felty Syndrome

A rare complication of rheumatoid arthritis with autoimmune NEUTROPENIA; and SPLENOMEGALY.

Synonym
Familial Felty Syndrome
Rheumatoid Arthritis, Splenomegaly and Neutropenia
Familial Felty's Syndrome
Felty's Syndrome
Felty Syndrome

Excerpt	Reference
"Felty's syndrome is diagnosed when a patient shows both splenomegaly and leukocytopenia of various degree during the course of rheumatoid arthritis (RA)."	( Inoh, M; Kurata, N; Maruoka, T; Takahara, J; Tokuda, M, 1995)
"Felty's syndrome is a rare but serious extra-articular manifestation of rheumatoid arthritis."	( Brücker, R; Schlumpf, U, 1996)
"Felty's syndrome is characterized by neutropenia, splenomegaly, and leg ulcers in patients with rheumatoid arthritis."	( Ishikawa, K; Kaneko, Y; Kuroiwa, T; Nojima, Y; Sugiura, T; Tamura, S; Tsukada, Y; Ueki, K, 2003)
"Felty syndrome is a rare and life-threatening type of rheumatoid arthritis (RA)."	( Li, J; Sun, W; Wu, P, 2020)
"Felty syndrome is a rare complication of RA."	( Li, J; Sun, W; Wu, P, 2020)

Excerpt	Reference
"Felty's syndrome has again been shown to be a severe form of systemic rheumatoid disease characterised by severe joint involvement, many extra-articular features, and a high incidence of infection."	( Thorne, C; Urowitz, MB, 1982)

Excerpt	Reference
"A 61-yr-old white man with Felty's syndrome, who had previously undergone splenectomy, presented for cytotoxic chemotherapy."	( Pazdur, R; Rossof, AH, 1981)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	174 (78.03)	23.3326
1990's	23 (10.31)	12.5806
2000's	9 (4.04)	18.1394
2010's	13 (5.83)	28.8240
2020's	4 (1.79)	9.53

Drug	Relationship Strength	Studies	Trials
porphobilinogen	low	2	0
mercaptoethanol	low	1	0
acetaminophen	low	1	0
azathioprine	low	5	0
bromhexine	low	1	0
chloroquine	low	2	0
dimercaprol	low	1	0
hydroxychloroquine	low	3	0
leflunomide	low	3	0
phenylbutazone	low	1	0
primidone	low	1	0
sulfasalazine	low	2	0
sulfobromophthalein	low	1	0
prednisolone	low	9	0
penicillamine	low	5	0
prednisone	low	21	0
isoflurophate	low	3	0
aminopyrine	low	1	0
phenylalanine	low	1	0
colchicine	low	1	0
methylprednisolone	low	4	0
penicillanic acid	low	1	0
isoxazoles	low	2	0
citrulline	low	1	0
betamethasone	low	1	0
lithium carbonate	low	4	0
dithiothreitol	low	1	0
streptomycin	low	1	0
vidarabine	low	1	0
technetium	low	2	0
gold	low	11	0
fluorine	low	1	0
trolamine salicylate	low	79	0
cetylpyridinium chloride anhydrous	low	1	0
ursodeoxycholic acid	low	1	0
etoposide	low	1	0
methyldopa	low	1	0
piperacillin	low	1	0
fibrinogen	low	3	0
methotrexate	low	25	0
cortisone	low	8	0
leucogenenol	low	1	0
pentostatin	low	1	0
n-formylmethionine leucyl-phenylalanine	low	1	0
fludarabine	low	1	0
propylthiouracil	low	1	0
lithium	medium	13	1
methenolone	low	1	0
bilirubin	low	1	0
amphotericin b	low	1	0
indium	low	1	0
nitrofurantoin	low	1	0
aurotioprol	low	1	0
losartan potassium	low	1	0
pituitrin	medium	2	1
oligonucleotides	low	1	0
piperacillin, tazobactam drug combination	low	1	0
methylcellulose	low	1	0
ascorbic acid	low	1	0
minocycline	low	1	0
salicylates	low	2	0
agar	low	1	0
technetium tc 99m sulfur colloid	low	2	0
vitamin b 12	low	1	0
cyclosporine	low	3	0
lactoferrin	low	1	0
muramidase	low	2	0
folic acid	low	2	0
phosphorus radioisotopes	low	1	0

Protein Targets (649)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
RAR-related orphan receptor gamma	14	0	0	14
ATAD5 protein, partial	8	0	0	8
GLS protein	9	0	0	9
Microtubule-associated protein tau	11	0	0	11
Smad3	7	0	0	7
aldehyde dehydrogenase 1 family, member A1	11	0	0	11
thyroid stimulating hormone receptor	8	0	0	8
nuclear receptor subfamily 1, group I, member 3	14	0	0	14
progesterone receptor	12	0	0	12
EWS/FLI fusion protein	10	0	0	10
retinoic acid nuclear receptor alpha variant 1	12	0	0	12
retinoid X nuclear receptor alpha	15	0	0	15
estrogen-related nuclear receptor alpha	18	0	0	18
estrogen nuclear receptor alpha	25	0	0	25
peroxisome proliferator activated receptor gamma	12	0	0	12
aryl hydrocarbon receptor	7	0	0	7
chromobox protein homolog 1	16	0	0	16
thyroid hormone receptor beta isoform 2	12	0	0	12
peripheral myelin protein 22	9	0	0	9
cytochrome P450 3A4 isoform 1	9	0	0	9
Gamma-aminobutyric acid receptor subunit pi	9	0	0	9
ATP-binding cassette sub-family C member 3	0	15	0	15
Multidrug resistance-associated protein 4	0	15	0	17
Solute carrier family 22 member 6	0	1	0	1
Carbonic anhydrase 12	0	1	0	2
UDP-glucuronosyltransferase 1A9	0	1	0	3
Bile salt export pump	0	8	0	8
Voltage-dependent calcium channel gamma-2 subunit	11	0	0	11
Bile salt export pump	0	26	0	26
Cytochrome P450 2B1	0	0	0	1
Cytochrome P450 1A1	0	0	0	1
Carbonic anhydrase 1	0	5	0	6
Carbonic anhydrase 2	0	5	1	7
Myoglobin	0	1	0	1
Cytochrome P450 1A1	0	0	1	2
Cytochrome P450 1A2	0	2	0	3
Prostaglandin G/H synthase 1	0	3	0	3
Carbonic anhydrase 3	0	1	0	2
Cytochrome P450 3A4	0	6	0	6
Cytochrome P450 2D6	0	3	0	3
Cytochrome P450 2C9	0	9	0	10
Polyunsaturated fatty acid lipoxygenase ALOX15	0	3	0	3
Gamma-aminobutyric acid receptor subunit beta-1	9	0	0	9
Sulfotransferase 1A1	0	0	0	1
Gamma-aminobutyric acid receptor subunit delta	9	0	0	9
Gamma-aminobutyric acid receptor subunit gamma-2	9	0	0	9
UDP-glucuronosyltransferase 1-6	0	2	0	3
Glutamate receptor 2	11	0	0	11
Gamma-aminobutyric acid receptor subunit alpha-5	9	0	0	9
Gamma-aminobutyric acid receptor subunit alpha-3	9	0	0	9
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	2	0	4
Carbonic anhydrase 4	0	2	0	3
Prostaglandin G/H synthase 1	0	2	0	2
Carbonic anhydrase 6	0	1	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	9	0	0	9
Gamma-aminobutyric acid receptor subunit alpha-2	9	0	0	9
Gamma-aminobutyric acid receptor subunit alpha-4	9	0	0	9
Gamma-aminobutyric acid receptor subunit gamma-3	9	0	0	9
Gamma-aminobutyric acid receptor subunit alpha-6	9	0	0	9
Carbonic anhydrase 5A, mitochondrial	0	1	0	2
Prostaglandin G/H synthase 2	0	3	0	4
Carbonic anhydrase 7	0	1	0	2
Nuclear receptor ROR-gamma	6	0	0	6
Cytochrome P450 2J2	0	6	0	6
Gamma-aminobutyric acid receptor subunit alpha-1	9	0	0	9
Gamma-aminobutyric acid receptor subunit beta-3	9	0	0	9
Gamma-aminobutyric acid receptor subunit beta-2	9	0	0	9
Carbonic anhydrase 9	0	2	0	3
GABA theta subunit	9	0	0	9
Canalicular multispecific organic anion transporter 1	0	14	0	15
Carbonic anhydrase 15	0	2	0	3
Carbonic anhydrase 13	0	1	0	2
Gamma-aminobutyric acid receptor subunit epsilon	9	0	0	9
Carbonic anhydrase 14	0	1	0	2
Carbonic anhydrase 5B, mitochondrial	0	1	0	2
toxin B	0	0	0	1
Chain A, Ferritin light chain	6	0	0	6
Luciferase	8	0	0	8
interleukin 8	5	0	0	5
thioredoxin reductase	12	0	0	12
15-lipoxygenase, partial	3	0	0	3
GLI family zinc finger 3	19	0	0	19
estrogen receptor 2 (ER beta)	6	0	0	6
cytochrome P450 family 3 subfamily A polypeptide 4	9	0	0	9
pregnane X nuclear receptor	13	0	0	13
G	7	0	0	7
peroxisome proliferator-activated receptor delta	11	0	0	11
vitamin D (1,25- dihydroxyvitamin D3) receptor	15	0	0	15
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	13	0	0	13
activating transcription factor 6	7	0	0	7
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	4	0	0	4
v-jun sarcoma virus 17 oncogene homolog (avian)	9	0	0	9
thyroid hormone receptor beta isoform a	5	0	0	5
histone deacetylase 9 isoform 3	3	0	0	3
nuclear factor erythroid 2-related factor 2 isoform 1	18	0	0	18
geminin	18	0	0	18
lamin isoform A-delta10	15	0	0	15
Interferon beta	11	0	0	11
HLA class I histocompatibility antigen, B alpha chain	7	0	0	7
Nicotinate phosphoribosyltransferase	0	2	0	2
Inositol hexakisphosphate kinase 1	7	0	0	7
cytochrome P450 2C9, partial	7	0	0	7
ORF73	0	0	2	2
Chain A, HADH2 protein	9	0	0	9
Chain B, HADH2 protein	9	0	0	9
Chain A, Cruzipain	2	0	0	2
phosphopantetheinyl transferase	10	0	0	10
glucocorticoid receptor [Homo sapiens]	18	0	0	18
farnesoid X nuclear receptor	9	0	0	9
tumor necrosis factor	1	0	0	1
vitamin D3 receptor isoform VDRA	10	0	0	10
Cytochrome P450 2C19	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	4	0	4
Aurora kinase B	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	2	0	3
Chain A, Hyaluronidase, phage associated	0	1	0	1
acetylcholinesterase	9	0	0	9
AR protein	20	0	0	20
thioredoxin glutathione reductase	7	0	0	7
IDH1	9	0	0	9
euchromatic histone-lysine N-methyltransferase 2	14	0	0	14
nuclear factor erythroid 2-related factor 2 isoform 2	13	0	0	13
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
lethal factor (plasmid)	4	0	0	4
Polyphenol oxidase 2	0	1	0	1
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	1	0	1
Urease	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	1	0	1
Alpha-2B adrenergic receptor	0	2	1	3
Spike glycoprotein	2	1	2	5
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	7	0	0	7
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	9	0	0	9
SMAD family member 2	5	0	0	5
Fumarate hydratase	4	0	0	4
SMAD family member 3	5	0	0	5
TDP1 protein	20	0	0	20
polyprotein	4	0	0	4
P53	2	0	0	2
arylsulfatase A	6	0	0	6
thyroid stimulating hormone receptor	4	0	0	4
Histone H2A.x	5	0	0	5
Bloom syndrome protein isoform 1	6	0	0	6
peripheral myelin protein 22 isoform 1	5	0	0	5
hemoglobin subunit beta	1	0	0	1
cellular tumor antigen p53 isoform a	4	0	0	4
heat shock protein beta-1	6	0	0	6
DNA polymerase iota isoform a (long)	8	0	0	8
survival motor neuron protein isoform d	7	0	0	7
M-phase phosphoprotein 8	5	0	0	5
muscleblind-like protein 1 isoform 1	8	0	0	8
muscarinic acetylcholine receptor M1	4	0	0	4
Cellular tumor antigen p53	13	0	0	13
ATPase family AAA domain-containing protein 5	11	0	0	11
Ataxin-2	13	0	0	13
Protein-arginine deiminase type-4	0	7	0	7
pregnane X receptor	6	0	0	6
nuclear receptor subfamily 1, group I, member 2	5	0	0	5
galanin receptor type 3	0	1	0	1
Glucocorticoid receptor	0	12	3	20
Glycine receptor subunit alpha-1	0	12	0	12
Glycine receptor subunit beta	0	12	0	12
Glycine receptor subunit alpha-2	0	12	0	12
Glycine receptor subunit alpha-3	0	12	0	12
Chain A, Putative fructose-1,6-bisphosphate aldolase	7	0	0	7
Chain A, 2-oxoglutarate Oxygenase	5	0	0	5
USP1 protein, partial	11	0	0	11
DNA polymerase kappa isoform 1	5	0	0	5
caspase-1 isoform alpha precursor	3	0	0	3
Caspase-7	3	0	0	3
Inositol monophosphatase 1	2	0	0	2
Solute carrier organic anion transporter family member 1B3	0	6	0	8
Solute carrier organic anion transporter family member 1B1	0	4	0	5
Sodium-dependent serotonin transporter	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	4	0	4
Carbonic anhydrase	0	1	0	2
hypoxia-inducible factor 1 alpha subunit	6	0	0	6
caspase 7, apoptosis-related cysteine protease	3	0	0	3
67.9K protein	6	0	0	6
caspase-3	3	0	0	3
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
thyrotropin-releasing hormone receptor	1	0	0	1
mitogen-activated protein kinase 1	2	0	0	2
nuclear receptor ROR-gamma isoform 1	4	0	0	4
Caspase-2	0	0	1	1
PPM1D protein	4	0	0	4
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0	1	0	1
Spike glycoprotein	0	1	2	3
Replicase polyprotein 1ab	0	1	3	4
glucose-6-phosphate 1-dehydrogenase isoform b	0	1	0	1
flap endonuclease 1	6	0	0	6
Transmembrane protease serine 2	0	1	2	3
Dihydrofolate reductase	0	2	0	2
DNA ligase	0	1	0	1
Riboflavin-binding protein	0	0	1	1
Major prion protein	0	0	1	1
Amyloid-beta precursor protein	0	1	0	1
Histidine-rich protein PFHRP-II	0	1	0	2
Procathepsin L	0	1	2	3
Muscarinic acetylcholine receptor M2	0	3	0	3
Muscarinic acetylcholine receptor M4	0	2	0	2
Muscarinic acetylcholine receptor M5	0	2	0	2
Alpha-2A adrenergic receptor	0	2	0	2
Replicase polyprotein 1a	0	1	2	3
Replicase polyprotein 1ab	0	1	2	3
Replicase polyprotein 1ab	0	2	2	4
Spike glycoprotein	0	1	0	1
Replicase polyprotein 1ab	0	2	2	4
Muscarinic acetylcholine receptor M1	0	2	0	2
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	1	0	1
Alpha-2C adrenergic receptor	0	2	0	2
DNA ligase 1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	2	0	2
Serine/threonine-protein kinase mTOR	0	1	0	1
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Beta-secretase 1	0	1	0	1
Calcium-dependent protein kinase 1	0	0	1	1
MO15-related protein kinase Pfmrk	0	1	0	1
DNA ligase A	0	1	0	1
Sigma intracellular receptor 2	0	2	0	2
Phosphoethanolamine N-methyltransferase	0	1	0	1
Angiotensin-converting enzyme 2	0	1	2	3
Cysteine proteinase falcipain 2a	0	1	0	1
Cysteine proteinase falcipain 2a	0	1	0	1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	1	0	1
General amino-acid permease GAP1	0	0	0	1
Nitric oxide synthase, brain	0	1	0	1
Nitric oxide synthase, brain	0	1	0	1
Chain A, Beta-lactamase	6	0	0	6
endonuclease IV	3	0	0	3
PAX8	0	0	0	1
Thrombopoietin	2	0	0	2
glucocerebrosidase	3	0	0	3
cytochrome P450 2D6 isoform 1	1	0	0	1
nuclear receptor subfamily 0 group B member 1	0	1	0	1
cytochrome P450 2C19 precursor	3	0	0	3
cytochrome P450 2C9 precursor	4	0	0	4
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
ras-related protein Rab-9A	2	0	0	2
steroidogenic factor 1	0	1	0	1
neuropeptide S receptor isoform A	3	0	0	3
Solute carrier family 22 member 3	0	1	0	1
Tubulin alpha-1A chain	0	2	1	3
Tubulin beta chain	0	2	1	3
Plasma kallikrein	0	0	0	2
Tubulin beta-4A chain	0	2	2	5
ATP-dependent translocase ABCB1	0	2	0	2
Tubulin beta chain	0	2	2	5
ATP-dependent translocase ABCB1	0	3	1	6
Tubulin alpha-3C chain	0	2	2	5
Serine/threonine-protein kinase pim-1	0	1	0	1
ATP-dependent translocase ABCB1	0	2	0	2
Histamine H2 receptor	4	0	0	4
Tubulin alpha-1B chain	0	2	2	5
Tubulin alpha-4A chain	0	2	2	5
Tubulin beta-4B chain	0	2	2	5
Vesicular acetylcholine transporter	0	1	0	1
Tubulin beta-3 chain	0	2	2	5
Tubulin beta-2A chain	0	2	2	5
Tubulin polymerization-promoting protein	0	0	1	1
Tubulin beta-8 chain	0	2	2	5
Tubulin beta-2B chain	0	3	0	3
Tubulin alpha-3E chain	0	2	2	5
Tubulin alpha-1A chain	0	2	2	5
Similar to alpha-tubulin isoform 1	0	2	0	2
Similar to alpha-tubulin isoform 1	0	2	0	2
CREB-binding protein	1	0	0	1
Tubulin alpha-1C chain	0	2	2	5
Tubulin beta-6 chain	0	2	2	5
Tubulin beta-2B chain	0	2	2	5
Tubulin beta-1 chain	0	2	2	5
ATP-dependent phosphofructokinase	6	0	0	6
dopamine D1 receptor	3	0	0	3
regulator of G-protein signaling 4	4	0	0	4
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
Sex hormone-binding globulin	0	0	2	2
Corticosteroid-binding globulin	0	3	0	3
Potassium voltage-gated channel subfamily A member 1	0	0	1	1
TAR DNA-binding protein 43	5	0	0	5
Multidrug and toxin extrusion protein 1	0	2	0	2
Aldo-keto reductase family 1 member B10	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Dihydrofolate reductase	0	3	0	4
Cytochrome c oxidase subunit 2	0	1	0	1
Fatty acid-binding protein, liver	0	2	0	2
Transthyretin	0	0	1	3
Albumin	0	1	2	3
Interleukin-8	0	1	0	1
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	1	0	1
Fatty acid-binding protein, intestinal	0	1	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
UDP-glucuronosyltransferase 2B7	0	1	0	2
UDP-glucuronosyltransferase 1A4	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
C-X-C chemokine receptor type 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Prostaglandin G/H synthase 2	0	2	0	2
UDP-glucuronosyltransferase 1A3	0	0	0	1
UDP-glucuronosyltransferase 2B10	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Solute carrier family 22 member 6	0	1	0	2
Prostaglandin G/H synthase 1	0	2	0	2
Carbonic anhydrase 4	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
UDP-glucuronosyltransferase 1A7	0	1	0	1
UDP-glucuronosyltransferase 1A10	0	1	0	1
cytochrome P450 2D6	3	0	0	3
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Chain H, IGG1-KAPPA DB3 FAB (HEAVY CHAIN)	0	1	0	1
Chain L, IGG1-KAPPA DB3 FAB (LIGHT CHAIN)	0	1	0	1
Chain H, IGG1-KAPPA DB3 FAB (HEAVY CHAIN)	0	1	0	1
Chain L, IGG1-KAPPA DB3 FAB (LIGHT CHAIN)	0	1	0	1
Chain H, IGG1-KAPPA DB3 FAB (HEAVY CHAIN)	0	1	0	1
Chain L, IGG1-KAPPA DB3 FAB (LIGHT CHAIN)	0	1	0	1
ClpP	2	0	0	2
Testosterone 17-beta-dehydrogenase 3	0	1	0	1
Guanine nucleotide-binding protein G	2	0	0	2
G-protein coupled bile acid receptor 1	0	0	2	2
glp-1 receptor, partial	4	0	0	4
LMP1 [Human herpesvirus 4]	0	0	0	1
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	2	0	2
urokinase-type plasminogen activator precursor	4	0	0	4
plasminogen precursor	4	0	0	4
urokinase plasminogen activator surface receptor precursor	4	0	0	4
transactivating tegument protein VP16 [Human herpesvirus 1]	0	2	0	2
nuclear receptor coactivator 3 isoform a	0	2	0	2
Prothrombin	0	0	0	1
Regulatory protein E2	0	0	1	1
DNA topoisomerase 1	0	1	0	2
DNA topoisomerase 2-alpha	0	1	1	7
DNA topoisomerase 2	0	0	0	1
Serum paraoxonase/arylesterase 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	0	0	2
Caspase-3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	0	0	2
Glutamate receptor ionotropic, NMDA 2B	0	0	0	2
Glutamate receptor ionotropic, NMDA 2C	0	0	0	2
DNA topoisomerase 2-alpha	0	0	0	1
DNA topoisomerase 2-beta	0	1	1	8
Glutamate receptor ionotropic, NMDA 2D	0	0	0	2
Integrase	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	0	0	2
Glutamate receptor ionotropic, NMDA 3A	0	0	0	2
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	5	0	0	5
corticotropin-releasing hormone receptor 2	0	1	1	2
corticotropin releasing factor-binding protein	0	1	1	2
glycogen synthase kinase-3 beta isoform 1	0	0	2	2
5'-nucleotidase	0	1	0	1
Adenosine receptor A3	0	1	0	1
Adenosine deaminase	0	1	0	3
Chain A, Dihydrofolate reductase	0	0	1	1
acid sphingomyelinase	2	0	0	2
alpha-galactosidase	2	0	0	2
lysosomal alpha-glucosidase preproprotein	2	0	0	2
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	5	0	0	5
DNA polymerase beta	4	0	0	4
Thymidylate synthase	0	4	0	4
Thymidylate synthase	0	3	0	3
Dihydrofolate reductase	0	2	3	5
Alpha-synuclein	2	0	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	4
Solute carrier organic anion transporter family member 1A3	0	1	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	4
Multidrug resistance associated protein	0	1	0	3
Genome polyprotein	0	1	0	1
Alpha-1D adrenergic receptor	0	2	0	2
Cyclic GMP-AMP synthase	0	1	0	1
Toll-like receptor 9	0	1	0	1
Toll-like receptor 7	0	1	0	1
Beta-lactamase	0	2	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase type 2	0	0	0	2
Metallo-beta-lactamase VIM-11	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	1	0	1
Metallo-beta-lactamase VIM-19	0	0	0	2
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	2
potassium voltage-gated channel subfamily H member 2 isoform d	2	0	0	2
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	4	0	0	4
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase SHV-1	0	0	0	2
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase type 2	0	0	0	1
Kappa-type opioid receptor	0	0	0	2
Beta-lactamase TEM	0	0	0	1
B2 metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-13	0	0	0	2
Metallo-beta-lactamase VIM-2	0	0	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-b-lactamase	0	0	0	2
Beta-lactamase IMP-1	0	0	0	1
BlaVIM-1	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	1
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	2
Histamine H3 receptor	0	0	0	2
Beta-lactamase class B VIM-2	0	0	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase VIM-1	0	0	0	2
Acetylcholinesterase	0	1	0	1
Acetylcholinesterase	0	0	1	1
Lysosomal protective protein	0	1	0	1
Fatty acid synthase	0	1	0	1
Acetylcholinesterase	0	2	1	3
Liver carboxylesterase	0	1	0	1
matrix metalloproteinase 1, partial	0	0	1	1
nonstructural protein 1	3	0	0	3
Parkin	2	0	0	2
pyruvate kinase	2	0	0	2
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
huntingtin isoform 2	1	0	0	1
histone acetyltransferase KAT2A isoform 1	4	0	0	4
Dihydroorotate dehydrogenase (quinone), mitochondrial	0	1	0	1
Integrin beta-3	2	0	0	2
Aldo-keto reductase family 1 member B1	0	2	0	2
Integrin alpha-IIb	2	0	0	2
Amine oxidase [flavin-containing] A	0	1	0	1
Endothelin receptor type B	1	0	0	1
Sodium-dependent noradrenaline transporter	0	2	0	2
Endothelin-1 receptor	1	0	0	1
Sodium-dependent dopamine transporter	0	2	0	2
Dihydroorotate dehydrogenase (quinone), mitochondrial	0	1	0	1
Dihydroorotate dehydrogenase (quinone), mitochondrial	0	1	0	1
Type-1A angiotensin II receptor	0	1	0	1
Type-1B angiotensin II receptor	0	2	0	2
Type-2 angiotensin II receptor	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Type-1 angiotensin II receptor	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
transcriptional regulator ERG isoform 3	1	0	0	1
importin subunit beta-1 isoform 1	2	0	0	2
snurportin-1	2	0	0	2
DNA polymerase eta isoform 1	2	0	0	2
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	0	1	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
5-hydroxytryptamine receptor 2C	0	1	0	2
High mobility group protein B1	0	0	1	1
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	0	1	1
Bifunctional purine biosynthesis protein ATIC	0	3	0	3
Multidrug resistance-associated protein 1	0	0	0	1
Delta-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Kappa-type opioid receptor	0	1	0	1
Reduced folate transporter	0	2	0	2
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Solute carrier family 22 member 8	0	1	0	2
Solute carrier family 22 member 6	0	1	0	1
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Solute carrier family 22 member 11	0	0	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	1	0	0	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
Caspase 6, apoptosis-related cysteine peptidase	0	0	0	1
apical membrane antigen 1, AMA1	1	0	0	1
hypothetical protein, conserved	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	2	0	0	2
estrogen receptor beta isoform 1	0	1	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
serine/threonine-protein kinase mTOR isoform 1	1	0	0	1
Rap guanine nucleotide exchange factor 3	2	0	0	2
Epidermal growth factor receptor	0	1	0	1
Tyrosine-protein kinase Fyn	0	1	0	1
Cystathionine gamma-lyase	0	2	0	2
Solute carrier family 15 member 1	0	2	0	2
D(1A) dopamine receptor	1	0	0	1
phosphoglycerate kinase	1	0	0	1
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
Androgen receptor	0	5	0	5
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Stromelysin-1	0	1	0	1
Matrilysin	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
Matrix metalloproteinase-9	0	1	0	1
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
Formyl peptide receptor-related sequence 1	0	0	1	1
fMet-Leu-Phe receptor	0	2	2	4
N-formyl peptide receptor 2	0	0	2	2
FML2_HUMAN	0	0	1	1
streptokinase A precursor	0	0	1	1
Estrogen receptor	0	0	1	1
60 kDa chaperonin	0	1	0	1
Estrogen receptor beta	0	0	1	1
10 kDa chaperonin	0	1	0	1
CDGSH iron-sulfur domain-containing protein 1	0	4	0	4
Succinyl-diaminopimelate desuccinylase	0	1	0	1
Adenosine deaminase	0	1	0	1
Adenosine deaminase	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
5'-nucleotidase	0	1	0	1
Adenosine receptor A1	0	0	0	1
Adenosine receptor A2a	0	0	0	1
Carbonic anhydrase	0	0	0	1
E3 ubiquitin-protein ligase XIAP	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	2
SLC16A10 protein	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase-like protein, putative	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	0	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase 13	0	0	0	1
Monocarboxylate transporter 10	0	0	0	1
Phospholipase A-2-activating protein	0	1	0	1
Estrogen receptor 1	0	1	0	1
D(1A) dopamine receptor	1	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	2	0	0	2
fMet-Leu-Phe receptor	0	1	0	1
Cyclooxygenase-2	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase OXA-7	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Class D beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Macrophage migration inhibitory factor	0	1	0	1
luciferase	0	0	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	2	0	2
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	0	2	2
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
NADH-cytochrome b5 reductase 3	0	1	0	1
Myeloperoxidase	0	1	0	1
Thyroid peroxidase	0	1	0	1
Taste receptor type 2 member 38	0	0	1	2
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, 146aa long hypothetical transcriptional regulator	0	0	1	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain B, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain C, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Anthranilate phosphoribosyltransferase	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	0	0	1
Chain A, Glutathione S-transferase	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	2	0	2
Tumor necrosis factor	0	0	1	1
Interstitial collagenase	0	1	0	1
Fibroblast growth factor 1	0	0	1	1
Thromboxane-A synthase	0	1	0	1
Mitogen-activated protein kinase 1	0	1	0	1
Caspase-1	0	1	0	1
Flavin reductase (NADPH)	0	0	1	1
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Sodium/bile acid cotransporter	0	2	0	2
Cystine/glutamate transporter	0	1	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
Hematopoietic prostaglandin D synthase	0	1	0	1
NFKB1 protein, partial	1	0	0	1
procathepsin L isoform 1 preproprotein	0	1	0	1
Ubiquitin carboxyl-terminal hydrolase 2	0	1	0	1
Vitamin D3 receptor	0	1	1	2
Ileal sodium/bile acid cotransporter	0	1	0	1
Bile acid receptor	0	0	1	1
M1-family alanyl aminopeptidase	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	1
Dipeptidyl peptidase 4	0	1	0	1
Adenosylhomocysteinase	0	1	0	1
RNA-directed RNA polymerase	0	1	1	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(5)

Research Excerpts

Overview

Context

Treatment

Research

Studies (223)

Protein Targets (649)

Familial Felty Syndrome

Synonyms(5)

Research Excerpts

Overview

Context

Treatment

Research

Studies (223)

Drugs Studied (87)

Protein Targets (649)