nonionic surfactant

A surfactant with an uncharged hydrophilic headgroup.

ChEBI ID: 38828

Members (6)

Member	Definition	Class
nonoxynol-9	A tergitol polymer consisting of nonylbenzene with a nine-membered poly(ethylene glycol) moiety attached at position 4.	tergitol NP-9
oleyl alcohol	A long chain fatty alcohol that is octadecanol containing a double bond located at position 9 (the Z-geoisomer).	(9Z)-octadecen-1-ol
pentaethylene glycol monododecyl ether	A hydroxypolyether that is pentaethylene glycol in which one of the terminal hydrogens is replaced by a dodecyl group.	laureth-5
polidocanol	A hydroxypolyether that is nonaethylene glycol in which one of the terminal hydroxy functions is substituted by a lauryl (dodecyl) group.	polidocanol
polyethylene glycol monostearate	An octadecanoate ester obtained by formal condensation between the carboxy group of octadecanoic (stearic) acid and one of the hydroxy groups of ethylene glycol. It is an ingredient in many personal care products and cosmetics.	2-hydroxyethyl octadecanoate
rhamnopyranosyl-3-hydroxydecanoyl-3-hydroxydecanoate	A glycolipid, an alpha-L-rhamnoside of 3-[(3-hydroxydecanoyl)oxy]decanoic acid.	L-rhamnosyl-3-hydroxydecanoyl-3-hydroxydecanoic acid

Research

Studies (1,296)

Timeframe	Studies, Drugs with This Role(%)	All Drugs %
pre-1990	198 (15.28)	18.7374
1990's	279 (21.53)	18.2507
2000's	304 (23.46)	29.6817
2010's	355 (27.39)	24.3611
2020's	160 (12.35)	2.80

Study Types

Publication Type	Studies, Drugs with this Role (%)	All Drugs (%)
Trials	168 (12.19%)	5.53%
Reviews	70 (5.08%)	6.00%
Case Studies	185 (13.43%)	4.05%
Observational	10 (0.73%)	0.25%
Other	945 (68.58%)	84.16%

Protein Targets (77)

Potency Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
aldehyde dehydrogenase 1 family, member A1	Homo sapiens (human)	Potency	39.8107	1	1
AR protein	Homo sapiens (human)	Potency	5.8492	7	8
Ataxin-2	Homo sapiens (human)	Potency	2.1132	1	1
ATPase family AAA domain-containing protein 5	Homo sapiens (human)	Potency	2.1132	1	1
caspase 7, apoptosis-related cysteine protease	Homo sapiens (human)	Potency	33.4915	1	1
caspase-1 isoform alpha precursor	Homo sapiens (human)	Potency	31.6228	1	1
caspase-3	Homo sapiens (human)	Potency	33.4915	1	1
Cellular tumor antigen p53	Homo sapiens (human)	Potency	31.6704	2	2
Chain A, Cruzipain	Trypanosoma cruzi	Potency	10.0000	1	1
Chain A, Ferritin light chain	Equus caballus (horse)	Potency	35.4813	1	1
cytochrome P450 2C9, partial	Homo sapiens (human)	Potency	21.8761	1	1
cytochrome P450 2D6	Homo sapiens (human)	Potency	12.3018	1	1
cytochrome P450 3A4 isoform 1	Homo sapiens (human)	Potency	31.6228	2	2
cytochrome P450 family 3 subfamily A polypeptide 4	Homo sapiens (human)	Potency	8.7090	1	1
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	Homo sapiens (human)	Potency	10.5909	1	1
Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)	Potency	2.5119	1	1
estrogen nuclear receptor alpha	Homo sapiens (human)	Potency	7.9567	8	9
estrogen receptor 2 (ER beta)	Homo sapiens (human)	Potency	20.9521	2	2
estrogen-related nuclear receptor alpha	Homo sapiens (human)	Potency	3.8475	6	6
farnesoid X nuclear receptor	Homo sapiens (human)	Potency	33.4889	1	1
G	Vesicular stomatitis virus	Potency	21.8761	1	1
GABA theta subunit	Rattus norvegicus (Norway rat)	Potency	31.6228	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	Rattus norvegicus (Norway rat)	Potency	31.6228	1	1
Gamma-aminobutyric acid receptor subunit alpha-2	Rattus norvegicus (Norway rat)	Potency	31.6228	1	1
Gamma-aminobutyric acid receptor subunit alpha-3	Rattus norvegicus (Norway rat)	Potency	31.6228	1	1
Gamma-aminobutyric acid receptor subunit alpha-4	Rattus norvegicus (Norway rat)	Potency	31.6228	1	1
Gamma-aminobutyric acid receptor subunit alpha-5	Rattus norvegicus (Norway rat)	Potency	31.6228	1	1
Gamma-aminobutyric acid receptor subunit alpha-6	Rattus norvegicus (Norway rat)	Potency	31.6228	1	1
Gamma-aminobutyric acid receptor subunit beta-1	Rattus norvegicus (Norway rat)	Potency	31.6228	1	1
Gamma-aminobutyric acid receptor subunit beta-2	Rattus norvegicus (Norway rat)	Potency	31.6228	1	1
Gamma-aminobutyric acid receptor subunit beta-3	Rattus norvegicus (Norway rat)	Potency	31.6228	1	1
Gamma-aminobutyric acid receptor subunit delta	Rattus norvegicus (Norway rat)	Potency	31.6228	1	1
Gamma-aminobutyric acid receptor subunit epsilon	Rattus norvegicus (Norway rat)	Potency	31.6228	1	1
Gamma-aminobutyric acid receptor subunit gamma-1	Rattus norvegicus (Norway rat)	Potency	31.6228	1	1
Gamma-aminobutyric acid receptor subunit gamma-2	Rattus norvegicus (Norway rat)	Potency	31.6228	1	1
Gamma-aminobutyric acid receptor subunit gamma-3	Rattus norvegicus (Norway rat)	Potency	31.6228	1	1
Gamma-aminobutyric acid receptor subunit pi	Rattus norvegicus (Norway rat)	Potency	31.6228	1	1
geminin	Homo sapiens (human)	Potency	30.0534	2	2
GLI family zinc finger 3	Homo sapiens (human)	Potency	29.8289	2	3
glucocorticoid receptor [Homo sapiens]	Homo sapiens (human)	Potency	25.6535	3	3
Glutamate receptor 2	Rattus norvegicus (Norway rat)	Potency	6.6824	1	1
heat shock protein beta-1	Homo sapiens (human)	Potency	33.4889	2	2
HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)	Potency	21.8761	1	1
huntingtin isoform 2	Homo sapiens (human)	Potency	35.4813	1	1
hypoxia-inducible factor 1 alpha subunit	Homo sapiens (human)	Potency	26.8325	1	1
Inositol hexakisphosphate kinase 1	Homo sapiens (human)	Potency	21.8761	1	2
Interferon beta	Homo sapiens (human)	Potency	21.8761	1	1
lamin isoform A-delta10	Homo sapiens (human)	Potency	0.0089	1	1
mitogen-activated protein kinase 1	Homo sapiens (human)	Potency	31.6228	1	1
nuclear factor erythroid 2-related factor 2 isoform 1	Homo sapiens (human)	Potency	11.6923	2	2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	Homo sapiens (human)	Potency	26.8325	1	1
nuclear receptor ROR-gamma isoform 1	Mus musculus (house mouse)	Potency	35.4813	2	4
nuclear receptor subfamily 1, group I, member 2	Rattus norvegicus (Norway rat)	Potency	28.1838	1	1
nuclear receptor subfamily 1, group I, member 3	Homo sapiens (human)	Potency	17.7801	1	1
peripheral myelin protein 22	Rattus norvegicus (Norway rat)	Potency	19.1958	2	3
peroxisome proliferator activated receptor gamma	Homo sapiens (human)	Potency	20.5257	2	2
phosphopantetheinyl transferase	Bacillus subtilis	Potency	70.7946	1	2
potassium voltage-gated channel subfamily H member 2 isoform d	Homo sapiens (human)	Potency	25.1189	1	1
pregnane X nuclear receptor	Homo sapiens (human)	Potency	23.2424	2	3
progesterone receptor	Homo sapiens (human)	Potency	28.6008	2	2
RAR-related orphan receptor gamma	Mus musculus (house mouse)	Potency	7.1842	2	2
retinoic acid nuclear receptor alpha variant 1	Homo sapiens (human)	Potency	20.8983	3	3
retinoid X nuclear receptor alpha	Homo sapiens (human)	Potency	4.7716	2	2
SMAD family member 2	Homo sapiens (human)	Potency	9.5205	1	1
SMAD family member 3	Homo sapiens (human)	Potency	9.5205	1	1
Spike glycoprotein	Severe acute respiratory syndrome-related coronavirus	Potency	18.5232	2	3
survival motor neuron protein isoform d	Homo sapiens (human)	Potency	7.0795	1	1
TDP1 protein	Homo sapiens (human)	Potency	5.3428	2	3
thyroid hormone receptor beta isoform 2	Rattus norvegicus (Norway rat)	Potency	8.4127	2	2
thyroid hormone receptor beta isoform a	Homo sapiens (human)	Potency	0.0891	1	1
thyroid stimulating hormone receptor	Homo sapiens (human)	Potency	26.6032	1	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	Homo sapiens (human)	Potency	2.5119	1	1
USP1 protein, partial	Homo sapiens (human)	Potency	53.1764	1	2
v-jun sarcoma virus 17 oncogene homolog (avian)	Homo sapiens (human)	Potency	26.8325	2	2
Voltage-dependent calcium channel gamma-2 subunit	Mus musculus (house mouse)	Potency	6.6824	1	1

Inhibition Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
Solute carrier organic anion transporter family member 1B1	Homo sapiens (human)	IC50	3.4674	1	1
Solute carrier organic anion transporter family member 1B1	Homo sapiens (human)	Ki	1.9200	1	1
Solute carrier organic anion transporter family member 1B3	Homo sapiens (human)	IC50	3.7154	1	1
Solute carrier organic anion transporter family member 1B3	Homo sapiens (human)	Ki	2.8700	1	1