ascorbic-acid and benzothiophene
ascorbic-acid has been researched along with benzothiophene* in 3 studies
Other Studies
3 other study(ies) available for ascorbic-acid and benzothiophene
Article | Year |
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Benzo[b]thiophene-thiazoles as potent anti-Toxoplasma gondii agents: Design, synthesis, tyrosinase/tyrosine hydroxylase inhibitors, molecular docking study, and antioxidant activity.
Synthesis and investigation of anti-Toxoplasma gondii activity of novel thiazoles containing benzo [b]thiophene moiety are presented. Among the derivatives, compound 3k with adamantyl group shows exceptionally high potency against Me49 strain with IC Topics: Animals; Antioxidants; Antiprotozoal Agents; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Drug Design; Enzyme Inhibitors; Mice; Molecular Docking Simulation; Molecular Structure; Monophenol Monooxygenase; Structure-Activity Relationship; Thiazoles; Thiophenes; Toxoplasma; Tyrosine 3-Monooxygenase | 2019 |
Evaluation of the antioxidant properties of diarylamines in the benzo[b]thiophene series by free radical scavenging activity and reducing power.
The antioxidant properties of substituted diarylamines in the benzo[b]thiophene series were evaluated by their reducing power and free radical scavenging activity. The results were compared with those of standards: acid ascorbic for the first method and BHA and BHT for the second. For both methods it was possible to establish some structure-activity relationships (SARs) based on the position of the arylamination on the benzo[b]thiophene moiety, the presence of different substituents on the phenyl ring (F, 1 or 2 OMe) and on the thiophene ring (H, CO(2)Et, CO(2)H). Topics: Amines; Antioxidants; Ascorbic Acid; Catalysis; Free Radical Scavengers; Oxidation-Reduction; Palladium; Structure-Activity Relationship; Thiophenes | 2006 |
Effects of benzothiophene on male rats following short-term oral exposure.
The systemic toxicity of benzothiophene, a sulfur-containing heterocyclic present in petroleum, coal, and their derived products, was studied in male rats following short-term oral exposure. Male Sprague-Dawley rats (130 +/- 20 g) (n = 5 per dose group) were treated with benzothiophene by gavage at dosages of 0, 2, 20 or 200 mg/kg/d for 21 d. In another study, male rats were treated with 0, 100, or 500 ppm benzothiophene via the diet for 28 d. In the gavage study, the 200 mg/kg/d rats showed depressed weight gain, increased relative liver and kidney weights, decreased relative thymus weights, and elevated levels of serum gamma-glutamyltransferase (gamma-GT), hepatic aniline hydroxylase (AH), aminopyrine N-demethylase (APDM), pentoxyresorufin O-dealkylase (PROD), glutathione S-transferase (GST), and UDP-glucuronosyltransferase (UDPGT) activities. A 4.5-fold increase in urine volume on d 14-21 and a transient, 4-fold increase in urinary ascorbic acid on d 1 were also detected. No treatment related changes in urinary N-acetylglucosaminidase (NAGA) activity were observed. Benzothiophene residues were not detected in adipose tissue, liver, and serum of rats in the 200 mg/kg rats, but a small quantity was detected in the urine. In the diet study, animals fed the 500 ppm diet had increased absolute and relative liver weights, elevated AH, APDM, and GST activities, decreased red blood cell count, and minor increases in serum urea nitrogen and glucose. In summary, benzothiophene produced adverse effects in male rats that included increased relative liver and kidney weights and increased urine output. Benzothiophene also caused increases in hepatic drug metabolizing enzyme activities of a phenobarbital type and a transient elevation in urinary ascorbic acid. Topics: Administration, Oral; Animal Feed; Animals; Ascorbic Acid; Dose-Response Relationship, Drug; Eating; Environmental Pollutants; Kidney; Liver; Male; Microsomes, Liver; Organ Size; Rats; Rats, Sprague-Dawley; Thiophenes; Thymus Gland; Weight Gain | 1997 |