An EC 4.2.1.* (hydro-lyases) inhibitor that interferes with the action of cystathionine beta-synthase (EC 4.2.1.22).
ChEBI ID: 63157
| Member | Definition | Class |
|---|---|---|
| aminooxyacetic acid | A member of the class of hydroxylamines that is acetic acid substituted at postion 2 by an aminooxy group. It is a compound which inhibits aminobutyrate aminotransferase activity in vivo, resulting in increased levels of gamma-aminobutyric acid in tissues. | (aminooxy)acetic acid |
| hydroxylamine | The simplest hydroxylamine, consisting of ammonia bearing a hydroxy substituent. It is an intermediate in the biological nitrification by microbes like bacteria. | hydroxylamine |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 909 (36.70) | 18.7374 |
| 1990's | 646 (26.08) | 18.2507 |
| 2000's | 413 (16.67) | 29.6817 |
| 2010's | 423 (17.08) | 24.3611 |
| 2020's | 86 (3.47) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 7 (0.27%) | 5.53% |
| Reviews | 47 (1.82%) | 6.00% |
| Case Studies | 8 (0.31%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 2,524 (97.60%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| arylsulfatase A | Homo sapiens (human) | Potency | 18.9966 | 1 | 2 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 29.0810 | 1 | 1 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 0.0120 | 1 | 1 |
| atrial natriuretic peptide receptor 1 precursor | Homo sapiens (human) | Potency | 0.8492 | 1 | 1 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 5.0119 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 0.0060 | 1 | 1 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 0.1458 | 1 | 1 |
| dopamine D1 receptor | Homo sapiens (human) | Potency | 5.8048 | 1 | 1 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 8.5965 | 1 | 2 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 1.1334 | 2 | 2 |
| NFKB1 protein, partial | Homo sapiens (human) | Potency | 15.8489 | 2 | 2 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 0.7512 | 1 | 1 |
| Single-stranded DNA cytosine deaminase | Homo sapiens (human) | Potency | 49.2215 | 2 | 4 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 2.4205 | 2 | 3 |
| Thrombopoietin | Homo sapiens (human) | Potency | 5.0119 | 2 | 2 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 31.6228 | 2 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Cystathionine beta-synthase | Homo sapiens (human) | IC50 | 5.2750 | 4 | 4 |
| Cystathionine gamma-lyase | Homo sapiens (human) | IC50 | 2.2850 | 2 | 2 |