Page last updated: 2024-08-05 12:46:18
epoxy steroid
Any steroid whose structure includes an epoxy group.
ChEBI ID: 145217
Members (13)
| Member | Definition | Role |
|---|---|---|
| 2,3-dihydro-3beta-methoxy withaferin A | A withanolide that is 2,3-dihydrowithaferin A substituted by a beta-methoxy group at position 3. It has been isolated from the aerial parts of Physalis longifolia. | 2,3-dihydro-3beta-methoxy withaferin A |
| 2,3-dihydro-3beta-O-sulfate withaferin A | A withanolide that is 2,3-dihydrowithaferin A substituted by a sulfoxy group at position 3. Isolated from Physalis longifolia, it exhibits antineoplastic activity. | 2,3-dihydro-3beta-O-sulfate withaferin A |
| 2,3-dihydrowithaferin A | A withanolide that is the 2,3-dihydro derivative of withaferin A. It has been isolated from the aerial parts of Physalis longifolia. | 2,3-dihydrowithaferin A |
| 24,25-epoxycholesterol | A 3beta-hydroxy-Delta(5)-steroid that is desmosterol in which the double bond at position 24-25 has been oxidised to the corresponding epoxide (the 24S diastereoisomer). It is an oxysterol agonist of the liver X receptor. | 24(S),25-epoxycholesterol |
| bufogenin | A steroid lactone of Chan su (toad venom), a Chinese medicine obtained from the skin venom gland of toads. A specific Na/K-ATPase protein inhibitor, it is used as a cardiotonic and central nervous system (CNS) respiratory agent, an analgesic and anesthetic, and as a remedy for ulcers. | bufogenin |
| cholesterol alpha-oxide | 5,6alpha-epoxy-5alpha-cholestan-3beta-ol | |
| eplerenone | eplerenone | |
| marinobufagenin | A cardiotonic steroid secreted by the toad Bufo rubescens and other related species such as Bufo marinus. An endogenous Na/K-ATPase inhibitor, it is a vasoconstrictor with effects similar to digitalis. | marinobufagenin |
| physalin f | A physalin with antimalarial and antitumour activities isolated from Physalis angulata. | physalin F |
| trilostane | An epoxy steroid that is 3,17beta-dihydroxy-5alpha-androst-2-ene-2-carbonitrile in which the oxygen of the epoxy group is joined to the 4alpha and 5 alpha positions. | trilostane |
| tubocapsanolide a | A withanolide that is 5beta,6beta:16alpha,17alpha-diepoxywitha-2,24-dienolide substituted by a hydroxy group at position 4 and an oxo group at position 1. Isolated from Tubocapsicum anomalum, it exhibits cytotoxic activity. | tubocapsanolide A |
| withaferin a | A withanolide that is 5,6:22,26-diepoxyergosta-2,24-diene-1,26-dione substituted by hydroxy groups at positions 4 and 27 (the 4beta,5beta,6beta,22R stereoisomer). Isolated from Physalis longifolia, it exhibits cytotoxic activity. | withaferin A |
| withanolide d | A withanolide that is 5,6:22,26-diepoxyergosta-2,24-diene-1,26-dione substituted by hydroxy groups at positions 4 and 22 (the 4beta,5beta,6beta,22R stereoisomer). Isolated from Tubocapsicum anomalum and Withania somnifera, it exhibits cytotoxic activity. | withanolide D |
Research
Studies (2,269)
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|---|---|
| pre-1990 | 141 (6.21) | 18.7374 |
| 1990's | 112 (4.94) | 18.2507 |
| 2000's | 648 (28.56) | 29.6817 |
| 2010's | 1,031 (45.44) | 24.3611 |
| 2020's | 337 (14.85) | 2.80 |
Study Types
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|---|---|
| Trials | 216 (8.94%) | 5.53% |
| Reviews | 323 (13.37%) | 6.00% |
| Case Studies | 79 (3.27%) | 4.05% |
| Observational | 8 (0.33%) | 0.25% |
| Other | 1,789 (74.08%) | 84.16% |