Page last updated: 2024-09-28

Canine Hip Dysplasia

A hereditary disease of the hip joints in dogs. Signs of the disease may be evident any time after 4 weeks of age.

Synonyms(2)

Synonym
Hip Dysplasia, Canine
Canine Hip Dysplasia

Research Excerpts

Research

Studies (34)

TimeframeStudies, This Condition (%)All Conditions %
pre-199011 (32.35)23.3326
1990's5 (14.71)12.5806
2000's11 (32.35)18.1394
2010's7 (20.59)28.8240
2020's0 (0.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
chlorine0low10
carprofen0medium22
diazepam0medium11
ketoprofen0medium11
xylazine0low20
estriol0low10
estrone0low10
acepromazine0low20
dihydrotestosterone0low10
gold0medium63
trolamine salicylate0medium21
cetylpyridinium chloride anhydrous0low10
cefazolin0low10
fadrozole0medium11
medetomidine0low20
keratan sulfate0low10
buprenorphine0medium11
dexmedetomidine0medium11
butorphanol0medium21
silicon0low20
strontium radioisotopes0low10
ascorbic acid0low30
chondroitin sulfates0low20

Protein Targets (318)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
thyroid stimulating hormone receptor3003
cytochrome P450 2D6 isoform 13003
geminin6006
lethal factor (plasmid)2002
lamin isoform A-delta106006
Bile salt export pump0707
Major prion protein0011
Trypanothione reductase0101
Chain A, Hyaluronidase, phage associated0101
acetylcholinesterase2002
RAR-related orphan receptor gamma8008
GLI family zinc finger 37007
AR protein7007
thioredoxin glutathione reductase1001
cytochrome P450 family 3 subfamily A polypeptide 43003
glucocorticoid receptor [Homo sapiens]8008
retinoic acid nuclear receptor alpha variant 17007
estrogen-related nuclear receptor alpha5005
estrogen nuclear receptor alpha8008
vitamin D (1,25- dihydroxyvitamin D3) receptor8008
IDH11001
euchromatic histone-lysine N-methyltransferase 24004
chromobox protein homolog 13003
nuclear factor erythroid 2-related factor 2 isoform 21001
thyroid hormone receptor beta isoform 25005
nuclear factor erythroid 2-related factor 2 isoform 14004
lethal(3)malignant brain tumor-like protein 1 isoform I1001
Polyphenol oxidase 20101
Pancreatic alpha-amylase0202
Albumin0101
Urease0101
Prolyl 4-hydroxylase subunit alpha-10001
Tyrosinase0101
Alpha-2B adrenergic receptor0011
Spike glycoprotein3003
Hyaluronate lyase0101
Prolyl hydroxylase EGLN20001
Egl nine homolog 10001
Prolyl hydroxylase EGLN30001
Hypoxia-inducible factor 1-alpha inhibitor0001
Solute carrier family 23 member 10101
Kappa-type opioid receptor0101
Kappa-type opioid receptor0213
ATP-binding cassette sub-family C member 30303
Multidrug resistance-associated protein 40304
Mu-type opioid receptor0202
Delta-type opioid receptor0101
Canalicular multispecific organic anion transporter 10202
Chain A, Beta-lactamase2002
Luciferase3003
SMAD family member 24004
SMAD family member 34004
Microtubule-associated protein tau3003
progesterone receptor7007
nonstructural protein 12002
retinoid X nuclear receptor alpha5005
67.9K protein2002
peroxisome proliferator-activated receptor delta4004
peroxisome proliferator activated receptor gamma5005
activating transcription factor 64004
vitamin D3 receptor isoform VDRA4004
histone deacetylase 9 isoform 31001
histone acetyltransferase KAT2A isoform 11001
Complement C50011
Cellular tumor antigen p533003
Prostaglandin G/H synthase 10202
Prostaglandin G/H synthase 10202
Prostaglandin G/H synthase 20202
Fatty-acid amide hydrolase 10101
TAR DNA-binding protein 432002
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
Chain A, JmjC domain-containing histone demethylation protein 3A1001
thioredoxin reductase1001
phosphopantetheinyl transferase1001
Smad31001
apical membrane antigen 1, AMA11001
cytochrome P450 2D63003
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
Solute carrier family 22 member 60202
Solute carrier family 15 member 10101
Solute carrier family 22 member 60202
Solute carrier family 22 member 80202
Solute carrier family 22 member 110101
Solute carrier family 22 member 80101
Chain A, Ferritin light chain1001
hypoxia-inducible factor 1 alpha subunit1001
USP1 protein, partial1001
TDP1 protein4004
caspase 7, apoptosis-related cysteine protease1001
estrogen receptor 2 (ER beta)5005
nuclear receptor subfamily 1, group I, member 34004
farnesoid X nuclear receptor1001
caspase-31001
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a4004
thyrotropin-releasing hormone receptor2002
v-jun sarcoma virus 17 oncogene homolog (avian)2002
heat shock protein beta-11001
mitogen-activated protein kinase 12002
nuclear receptor ROR-gamma isoform 12002
survival motor neuron protein isoform d2002
Voltage-dependent calcium channel gamma-2 subunit4004
Glutamate receptor 24004
Caspase-20011
Inositol monophosphatase 12002
ATPase family AAA domain-containing protein 52002
Ataxin-22002
Carbonic anhydrase 10202
Carbonic anhydrase 20202
Carbonic anhydrase 40101
Carbonic anhydrase0101
Carbonic anhydrase 150101
Alpha-1B adrenergic receptor 0011
cellular tumor antigen p53 isoform a1001
cytochrome P450 2C19 precursor1001
cytochrome P450 2C9 precursor1001
peripheral myelin protein 222002
cytochrome P450 3A4 isoform 15005
Gamma-aminobutyric acid receptor subunit pi5218
Alpha-2A adrenergic receptor0213
Gamma-aminobutyric acid receptor subunit beta-15218
Alpha-1B adrenergic receptor0213
Alpha-1A adrenergic receptor0011
Gamma-aminobutyric acid receptor subunit delta5218
Gamma-aminobutyric acid receptor subunit gamma-25218
Alpha-2C adrenergic receptor0112
Alpha-2B adrenergic receptor0202
Gamma-aminobutyric acid receptor subunit alpha-55218
Gamma-aminobutyric acid receptor subunit alpha-35218
Alpha-2C adrenergic receptor0202
Alpha-2A adrenergic receptor0202
Gamma-aminobutyric acid receptor subunit gamma-15218
Gamma-aminobutyric acid receptor subunit alpha-25218
Alpha-1D adrenergic receptor0213
Alpha-1D adrenergic receptor0101
Gamma-aminobutyric acid receptor subunit alpha-45218
Gamma-aminobutyric acid receptor subunit gamma-35218
Gamma-aminobutyric acid receptor subunit alpha-65218
Alpha-1A adrenergic receptor0213
Histamine H2 receptor1001
Gamma-aminobutyric acid receptor subunit alpha-15218
Gamma-aminobutyric acid receptor subunit beta-35218
Gamma-aminobutyric acid receptor subunit beta-25218
GABA theta subunit5218
Gamma-aminobutyric acid receptor subunit epsilon5218
Gamma-aminobutyric acid 0101
glp-1 receptor, partial2002
pregnane X nuclear receptor4004
G3003
Gamma-aminobutyric acid receptor subunit pi0202
Gamma-aminobutyric acid receptor subunit delta0202
Voltage-dependent L-type calcium channel subunit alpha-1F0101
Interferon beta3003
HLA class I histocompatibility antigen, B alpha chain 3003
Fatty acid-binding protein, liver0101
Alpha-1-acid glycoprotein 10001
Albumin0113
Albumin0011
ATP-dependent translocase ABCB10001
Gamma-aminobutyric acid receptor subunit alpha-10202
Gamma-aminobutyric acid receptor subunit beta-10202
Neuronal acetylcholine receptor subunit alpha-40101
Gamma-aminobutyric acid receptor subunit alpha-20202
Gamma-aminobutyric acid receptor subunit alpha-30202
Neuronal acetylcholine receptor subunit beta-20101
Gamma-aminobutyric acid receptor subunit alpha-10224
Translocator protein0113
Gamma-aminobutyric acid receptor subunit alpha-60101
Gamma-aminobutyric acid receptor subunit beta-10202
Gamma-aminobutyric acid receptor subunit gamma-20213
5-hydroxytryptamine receptor 1A0213
Gamma-aminobutyric acid receptor subunit alpha-40202
Gamma-aminobutyric acid receptor subunit gamma-20202
Gamma-aminobutyric acid receptor subunit gamma-20101
Gamma-aminobutyric acid receptor subunit delta0101
Gamma-aminobutyric acid receptor subunit alpha-20101
Gamma-aminobutyric acid receptor subunit alpha-30101
Gamma-aminobutyric acid receptor subunit gamma-30101
Gamma-aminobutyric acid receptor subunit beta-30213
Translocator protein0101
Translocator protein0101
Cholecystokinin receptor type A0101
Gastrin/cholecystokinin type B receptor0101
Gamma-aminobutyric acid receptor subunit alpha-50224
Gamma-aminobutyric acid receptor subunit alpha-30213
Gamma-aminobutyric acid receptor subunit alpha-20213
Gamma-aminobutyric acid receptor subunit beta-20213
Gamma-aminobutyric acid receptor subunit alpha-40202
Gamma-aminobutyric acid receptor subunit beta-10101
Gamma-aminobutyric acid receptor subunit alpha-10101
Gamma-aminobutyric acid receptor subunit beta-30101
Gamma-aminobutyric acid receptor subunit epsilon0202
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
Neuronal acetylcholine receptor subunit alpha-70101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Gamma-aminobutyric acid receptor subunit alpha-60202
Gamma-aminobutyric acid receptor subunit alpha-50101
Gamma-aminobutyric acid receptor subunit gamma-10202
Gamma-aminobutyric acid receptor subunit pi0101
Sphingosine-1-phosphate lyase 10101
Inositol hexakisphosphate kinase 13003
Gamma-aminobutyric acid receptor subunit gamma-30202
Gamma-aminobutyric acid receptor subunit alpha-40101
Gamma-aminobutyric acid receptor subunit theta0101
Gamma-aminobutyric acid receptor subunit gamma-10101
Gamma-aminobutyric acid receptor subunit theta0202
cytochrome P450 2C9, partial3003
Chain A, Sex Hormone-Binding Globulin0011
Chain A, HADH2 protein3003
Chain B, HADH2 protein3003
interleukin 81001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a2002
Histone H2A.x1001
potassium voltage-gated channel subfamily H member 2 isoform d1001
transcriptional regulator ERG isoform 31001
Plasma kallikrein0101
Glucocorticoid receptor0304
Sex hormone-binding globulin0134
Progesterone receptor0101
Progesterone receptor0112
Glucocorticoid receptor0101
Corticosteroid-binding globulin0303
Mineralocorticoid receptor 0101
Sex hormone-binding globulin0101
Androgen receptor0226
Aromatase0405
Androgen receptor0516
Androgen receptor0112
Mineralocorticoid receptor0101
Testosterone 17-beta-dehydrogenase 30101
Angiotensin-converting enzyme0011
Cannabinoid receptor 20101
Nuclear receptor ROR-gamma1001
G-protein coupled bile acid receptor 10011
Muscarinic acetylcholine receptor0101
Neuropeptide FF receptor 20001
ALK tyrosine kinase receptor0101
Estrogen receptor0416
Glycine receptor subunit alpha-10202
Polyunsaturated fatty acid lipoxygenase ALOX150202
UDP-glucuronosyltransferase 2B70002
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
Sodium-dependent serotonin transporter0404
Alpha-synuclein0202
Solute carrier organic anion transporter family member 1A10202
Lanosterol 14-alpha demethylase0011
Olfactory receptor 51E20011
UDP-glucuronosyltransferase 1A100001
endonuclease IV1001
ATAD5 protein, partial2002
NFKB1 protein, partial1001
GALC protein1001
arylsulfatase A2002
Bloom syndrome protein isoform 11001
hexokinase-4 isoform 11001
peripheral myelin protein 22 isoform 12002
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
glucokinase regulatory protein1001
DNA polymerase iota isoform a (long)1001
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
Rap guanine nucleotide exchange factor 31001
Steryl-sulfatase0101
17-beta-hydroxysteroid dehydrogenase type 10203
Mu-type opioid receptor0011
5-hydroxytryptamine receptor 2B0202
Mu-type opioid receptor0011
Cytochrome P450 1B10101
Estrogen receptor beta0113
Ghrelin O-acyltransferase0101
Broad substrate specificity ATP-binding cassette transporter ABCG20101
Steroid 17-alpha-hydroxylase/17,20 lyase0101
Cytochrome P450 3A40101
Cytochrome P450 2C9 0202
Cytochrome P450 11B1, mitochondrial0101
Cytochrome P450 11B2, mitochondrial0101
Cytochrome P450 11B2, mitochondrial0101
Cytochrome P450 11B2, mitochondrial0101
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE2002
Chain A, 2-oxoglutarate Oxygenase1001
GTP-binding protein (rab7)0011
ras protein, partial0011
aldehyde dehydrogenase 1 family, member A11001
regulator of G-protein signaling 41001
EWS/FLI fusion protein1001
Rac1 protein0011
cell division cycle 42 (GTP binding protein, 25kDa), partial0011
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
flap endonuclease 11001
Epidermal growth factor receptor0101
Seed linoleate 13S-lipoxygenase-10101
Fatty acid-binding protein, intestinal0101
Aldo-keto reductase family 1 member B10101
Serum paraoxonase/arylesterase 10101
Caspase-10101
UDP-glucuronosyltransferase 1A30001
Caspase-30101
Caspase-40101
Cytochrome P450 2J20101
Caspase-50101
Caspase-90101
Ras-related protein Rab-2A0011
Guanine nucleotide-binding protein G1001
Solute carrier organic anion transporter family member 1A30101
Prostaglandin G/H synthase 20101
Lactoylglutathione lyase0101
Solute carrier family 22 member 70101
Sigma non-opioid intracellular receptor 10011
Sigma non-opioid intracellular receptor 10011
ATP-dependent phosphofructokinase1001
bromodomain adjacent to zinc finger domain 2B1001
atrial natriuretic peptide receptor 1 precursor1001
ras-related protein Rab-9A1001
muscarinic acetylcholine receptor M11001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]