| Assay ID | Title | Year | Journal | Article |
|---|
| AID1347086 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347096 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for U-2 OS cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347089 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for TC32 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347114 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for DAOY cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347109 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for NB1643 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347425 | Rhodamine-PBP qHTS Assay for Modulators of WT P53-Induced Phosphatase 1 (WIP1) | 2019 | The Journal of biological chemistry, 11-15, Volume: 294, Issue:46
| Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens. |
| AID1347116 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for SJ-GBM2 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347104 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for RD cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
| Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1347090 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for DAOY cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347093 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-MC cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347105 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for MG 63 (6-TG R) cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347118 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for TC32 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347126 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for Rh30 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347125 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for Rh18 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347129 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for SK-N-SH cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347098 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-SH cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347106 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for control Hh wild type fibroblast cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347115 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for NB-EBc1 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347121 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for control Hh wild type fibroblast cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347119 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for MG 63 (6-TG R) cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1508630 | Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay | 2021 | Cell reports, 04-27, Volume: 35, Issue:4
| A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. |
| AID1347083 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347091 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SJ-GBM2 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347113 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for LAN-5 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | | | |
| AID1347095 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB-EBc1 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347112 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for BT-12 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347099 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB1643 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347101 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-12 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347122 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for U-2 OS cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347127 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for Saos-2 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347097 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Saos-2 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1508629 | Cell Viability qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome | 2021 | Cell reports, 04-27, Volume: 35, Issue:4
| A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. |
| AID1347082 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347124 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for RD cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347407 | qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS Pharmaceutical Collection | 2020 | ACS chemical biology, 07-17, Volume: 15, Issue:7
| High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle. |
| AID1347102 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh18 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347154 | Primary screen GU AMC qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347128 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for OHS-50 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1508628 | Confirmatory qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay | 2021 | Cell reports, 04-27, Volume: 35, Issue:4
| A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. |
| AID1347108 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh41 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347092 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for A673 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347424 | RapidFire Mass Spectrometry qHTS Assay for Modulators of WT P53-Induced Phosphatase 1 (WIP1) | 2019 | The Journal of biological chemistry, 11-15, Volume: 294, Issue:46
| Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens. |
| AID1347110 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for A673 cells) | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1745845 | Primary qHTS for Inhibitors of ATXN expression | | | |
| AID1347117 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for BT-37 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1508627 | Counterscreen qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: GLuc-NoTag assay | 2021 | Cell reports, 04-27, Volume: 35, Issue:4
| A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. |
| AID1347094 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-37 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347100 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for LAN-5 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347111 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for SK-N-MC cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347123 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Confirmatory screen for Rh41 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347103 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for OHS-50 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID1347107 | qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh30 cells | 2018 | Oncotarget, Jan-12, Volume: 9, Issue:4
| Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing. |
| AID504749 | qHTS profiling for inhibitors of Plasmodium falciparum proliferation | 2011 | Science (New York, N.Y.), Aug-05, Volume: 333, Issue:6043
| Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets. |
| AID585913 | Antibacterial activity against Streptococcus pneumoniae M302 overexpressing patA, patB and inactivated patA with single mutation by standardized agar doubling dilution method in presence of 20 ug/ml reserpine efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID405379 | Toxicity against human HepG2/C3A cells assessed as reduction in mitochondrial DNA copy numbers at 0.5 ug/ml after 10 days relative to control | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Absence of a universal mechanism of mitochondrial toxicity by nucleoside analogs. |
| AID406648 | Antibacterial activity against Staphylococcus aureus ACH-0206 isolate with gyrA Ser84Leu mutant after 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Dual targeting of DNA gyrase and topoisomerase IV: target interactions of heteroaryl isothiazolones in Staphylococcus aureus. |
| AID72882 | Thermal denaturation in alternating poly(dG-dC)-poly(dG-dC) homopolymer (GC) | 1993 | Journal of medicinal chemistry, Jun-11, Volume: 36, Issue:12
| Structure, DNA minor groove binding, and base pair specificity of alkyl- and aryl-linked bis(amidinobenzimidazoles) and bis(amidinoindoles). |
| AID585492 | Antibacterial activity against fluoroquinolone, dye-resistant Streptococcus pneumoniae by standardized agar doubling dilution method in presence of 50 uM sodium orthovanadate efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID1502708 | Antimycobacterial activity against Mycobacterium avium 104 mc'2 4 assessed as reduction in bacterial viability incubated for 3 days by MTT assay | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Natural isoflavone biochanin A as a template for the design of new and potent 3-phenylquinolone efflux inhibitors against Mycobacterium avium. |
| AID1743674 | Antimycobacterial activity against Mycobacterium smegmatis mc2 155 ATCC 700084 assessed as inhibition of visible growth of bacteria by MTT assay | 2020 | European journal of medicinal chemistry, Dec-01, Volume: 207 | Palladium-catalysed synthesis of arylnaphthoquinones as antiprotozoal and antimycobacterial agents. |
| AID576020 | Antimicrobial activity against Staphylococcus aureus RDN1 harboring cloned pTZ2238-encoded QacBIV A19T mutant gene by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10
| Fluoroquinolone efflux by the plasmid-mediated multidrug efflux pump QacB variant QacBIII in Staphylococcus aureus. |
| AID586118 | Antibacterial activity against fluoroquinolone-resistant Streptococcus pneumoniae M79 FQ-R overexpressing patA, patB by standardized agar doubling dilution method in presence of 50 uM sodium orthovanadate efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID585907 | Antibacterial activity against Streptococcus pneumoniae M316 overexpressing patA, patB and inactivated patA with single mutation by standardized agar doubling dilution method in presence of 20 ug/ml reserpine efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID339766 | Binding affinity to synthetic poly(dA-dT):poly(dA-dT) DNA:DNA duplex assessed as association constant at 20 degC | 2008 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 18, Issue:14
| Molecular recognition of a DNA:RNA hybrid: sub-nanomolar binding by a neomycin-methidium conjugate. |
| AID1447307 | Inhibition of DNA topoisomerase-1 (unknown origin) mediated DNA relaxation assessed as DNA intercalation at 1 ug/ml using supercoiled pBR322 plasmid DNA as substrate after 60 mins by ethidium bromide staining based agarose gel electrophoresis | 2017 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 27, Issue:9
| Design, synthesis and evaluation of 4-substituted anthra[2,1-c][1,2,5]thiadiazole-6,11-dione derivatives as novel non-camptothecin topoisomerase I inhibitors. |
| AID1339148 | Binding affinity to synthetic biotin-labeled 30-mer AT-rich duplex DNA in pH 7.8 Tris-Hcl buffer solution assessed as ratio of association rate constant to dissociation rate constant in presence of 0.1 M NaCl at 25 degC by QCM sensogram analysis | 2017 | Bioorganic & medicinal chemistry, 02-01, Volume: 25, Issue:3
| Determination of binding modes and binding constants for the complexes of 6H-pyrido[4,3-b]carbazole derivatives with DNA. |
| AID576015 | Antimicrobial activity against Staphylococcus aureus RDN1 harboring cloned pTZ2396-encoded QacA gene by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10
| Fluoroquinolone efflux by the plasmid-mediated multidrug efflux pump QacB variant QacBIII in Staphylococcus aureus. |
| AID736816 | Induction of DNA intercalation in negatively Escherichia coli super coiled small circular plasmid DNA assessed as retradation of DNA migration at 100 uM incubated for 20 mins at 37 degC by agarose-gel electrophoresis | 2013 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 23, Issue:4
| Indenoindolone derivatives as topoisomerase II-inhibiting anticancer agents. |
| AID1197382 | Binding affinity to Escherichia coli pBR322 DNA assessed as DNA intercalation activity compound preincubated for 10 mins before enzyme addition by DNA unwinding assay in presence of topoisomerase 1 | 2015 | European journal of medicinal chemistry, Mar-06, Volume: 92 | Design, synthesis and biological evaluation of novel 7-alkylamino substituted benzo[a]phenazin derivatives as dual topoisomerase I/II inhibitors. |
| AID1413834 | Induction of Escherichia coli pBR322 DNA intercalation assessed as transformation of topoisomerase1-relaxed pBR322 DNA in to supercoiled DNA at 5 uM preincubated for 10 mins followed by topoisomerase-1 addition and measured after 30 mins by agarose gel el | 2018 | MedChemComm, Jul-01, Volume: 9, Issue:7
| Design, synthesis and biological evaluation of benzimidazole-rhodanine conjugates as potent topoisomerase II inhibitors. |
| AID586113 | Antibacterial activity against Streptococcus pneumoniae M304 overexpressing patA, patB and inactivated patA with single mutation by standardized agar doubling dilution method in presence of 50 uM sodium orthovanadate efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID1339145 | Binding affinity to synthetic biotin-labeled 30-mer AT-rich duplex DNA in pH 7.8 Tris-Hcl buffer solution assessed as association rate constant in presence of 0.1 M NaCl at 25 degC by QCM sensogram analysis | 2017 | Bioorganic & medicinal chemistry, 02-01, Volume: 25, Issue:3
| Determination of binding modes and binding constants for the complexes of 6H-pyrido[4,3-b]carbazole derivatives with DNA. |
| AID532761 | Antimicrobial activity against Salmonella serovar Virchow 5742 by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10
| RamA confers multidrug resistance in Salmonella enterica via increased expression of acrB, which is inhibited by chlorpromazine. |
| AID520086 | Antimicrobial activity against acrAB-deficient Escherichia coli TG1 harboring AcrAB efflux pump by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
| Role of the AheABC efflux pump in Aeromonas hydrophila intrinsic multidrug resistance. |
| AID585731 | Antibacterial activity against Streptococcus pneumoniae M46B overexpressing patA, patB and inactivated patB with single mutation by standardized agar doubling dilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID586129 | Antibacterial activity against Streptococcus pneumoniae M307 overexpressing patA, patB and inactivated patB with single mutation by standardized agar doubling dilution method in presence of 50 uM sodium orthovanadate efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID585911 | Antibacterial activity against Streptococcus pneumoniae M319 overexpressing patA, patB and inactivated patB with single mutation by standardized agar doubling dilution method in presence of 20 ug/ml reserpine efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID532573 | Antimicrobial activity against Salmonella serovar Typhimurium SL1344 by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10
| RamA confers multidrug resistance in Salmonella enterica via increased expression of acrB, which is inhibited by chlorpromazine. |
| AID510748 | Antibacterial activity against Escherichia coli AG102MB harboring naive acrB gene | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
| Single nucleotide polymorphism analysis of the major tripartite multidrug efflux pump of Escherichia coli: functional conservation in disparate animal reservoirs despite exposure to antimicrobial chemotherapy. |
| AID585901 | Antibacterial activity against Streptococcus pneumoniae M304 overexpressing patA, patB and inactivated patA with single mutation by standardized agar doubling dilution method in presence of 20 ug/ml reserpine efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID586102 | Antibacterial activity against Streptococcus pneumoniae M50B overexpressing patA, patB and inactivated patB with single mutation by standardized agar doubling dilution method in presence of 50 uM sodium orthovanadate efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID1651227 | Binding affinity to supercoiled DNA (unknown origin) by SPR assay | 2020 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 30, Issue:4
| Synthesis and biological evaluation of novel indole-pyrazoline hybrid derivatives as potential topoisomerase 1 inhibitors. |
| AID1502713 | Antimycobacterial activity against Mycobacterium avium isolate MAV4 assessed as reduction in bacterial viability incubated for 3 days by MTT assay | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Natural isoflavone biochanin A as a template for the design of new and potent 3-phenylquinolone efflux inhibitors against Mycobacterium avium. |
| AID585912 | Antibacterial activity against fluoroquinolone-resistant Streptococcus pneumoniae M97 FQ-R overexpressing patA, patB by standardized agar doubling dilution method in presence of 20 ug/ml reserpine efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID585697 | Antibacterial activity against Streptococcus pneumoniae M301 overexpressing patA, patB and inactivated patA with single mutation by standardized agar doubling dilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID1888866 | Bactericidal activity against Staphylococcus aureus 1199B assessed as log reduction in bacterial count at 50 ug/mL measured after 8 hrs by time-kill kinetics assay | 2022 | Bioorganic & medicinal chemistry, 01-15, Volume: 54 | Potentiating the intracellular killing of Staphylococcus aureus by dihydroquinazoline analogues as NorA efflux pump inhibitor. |
| AID532763 | Antimicrobial activity against Salmonella serovar Typhimurium SL1344 expressing ramA::aph mutant by broth dilution method in presence of chlorpromazine | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10
| RamA confers multidrug resistance in Salmonella enterica via increased expression of acrB, which is inhibited by chlorpromazine. |
| AID1359222 | Induction of unwinding effect of Escherichia coli supercoiled pBR322 DNA at 0.3 to 1.2 mg/L preincubated with DNA for 10 mins followed by excess calf thymus TOP1 addition and measured after 30 mins by agarose gel electrophoresis | 2018 | European journal of medicinal chemistry, May-25, Volume: 152 | Synthesis, cytotoxicity and structure-activity relationship of indolizinoquinolinedione derivatives as DNA topoisomerase IB catalytic inhibitors. |
| AID510559 | Antibacterial activity against Escherichia coli AG102MB | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
| Single nucleotide polymorphism analysis of the major tripartite multidrug efflux pump of Escherichia coli: functional conservation in disparate animal reservoirs despite exposure to antimicrobial chemotherapy. |
| AID586099 | Antibacterial activity against Streptococcus pneumoniae M45B overexpressing patA, patB and inactivated patB with single mutation by standardized agar doubling dilution method in presence of 50 uM sodium orthovanadate efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID586096 | Antibacterial activity against Streptococcus pneumoniae M298 overexpressing patA, patB and inactivated patB with single mutation by standardized agar doubling dilution method in presence of 50 uM sodium orthovanadate efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID472809 | Inhibition of HCV genotype 1b NS5B polymerase deltaC21 mutant | 2010 | Bioorganic & medicinal chemistry, Apr-15, Volume: 18, Issue:8
| Allosteric inhibitors of hepatitis C virus NS5B polymerase thumb domain site II: structure-based design and synthesis of new templates. |
| AID644952 | Binding affinity to human pre-hsa-mir-155 miRNA assessed as increase in fluorescence after 30 mins by fluorimetry | 2012 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 22, Issue:4
| Pre-microRNA binding aminoglycosides and antitumor drugs as inhibitors of Dicer catalyzed microRNA processing. |
| AID1356628 | Antimicrobial activity against Staphylococcus aureus ATCC 25923 by microdilution method | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| 2-Phenylquinoline S. aureus NorA Efflux Pump Inhibitors: Evaluation of the Importance of Methoxy Group Introduction. |
| AID520082 | Antimicrobial activity against aheB deficient kanamycin-resistant Aeromonas hydrophila subsp. hydrophila ATCC 7966 harboring AheABC efflux pump by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
| Role of the AheABC efflux pump in Aeromonas hydrophila intrinsic multidrug resistance. |
| AID584116 | Ratio of MIC for Escherichia coli KAM32 harboring cloned pSP72 lmrS to MIC for Escherichia coli KAM32 harboring pSP72 | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12
| LmrS is a multidrug efflux pump of the major facilitator superfamily from Staphylococcus aureus. |
| AID510749 | Antibacterial activity against Escherichia coli AG102MB harboring pP10-based acrB gene | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
| Single nucleotide polymorphism analysis of the major tripartite multidrug efflux pump of Escherichia coli: functional conservation in disparate animal reservoirs despite exposure to antimicrobial chemotherapy. |
| AID586088 | Antibacterial activity against Streptococcus pneumoniae M46A overexpressing patA, patB and inactivated patA with single mutation by standardized agar doubling dilution method in presence of 20 ug/ml reserpine efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID585728 | Antibacterial activity against Streptococcus pneumoniae M55B overexpressing patA, patB and inactivated patB with single mutation by standardized agar doubling dilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID1594135 | Inhibition of native rhodanese (unknown origin) assessed as reduction in rhodanese enzyme activity after 45 mins by Fe(SCN)3 dye based spectrometric analysis | 2019 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 29, Issue:9
| HSP60/10 chaperonin systems are inhibited by a variety of approved drugs, natural products, and known bioactive molecules. |
| AID406655 | Antibacterial activity against Staphylococcus aureus ACH-0192 isolate with gyrA Ser84Leu and grlA Ser80Phe, Ala116Val mutant after 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Dual targeting of DNA gyrase and topoisomerase IV: target interactions of heteroaryl isothiazolones in Staphylococcus aureus. |
| AID283560 | Antibacterial activity against Escherichia coli HNCE4 after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3
| Substrate competition studies using whole-cell accumulation assays with the major tripartite multidrug efflux pumps of Escherichia coli. |
| AID585711 | Antibacterial activity against fluoroquinolone-resistant Streptococcus pneumoniae M79 FQ-R overexpressing patA, patB by standardized agar doubling dilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID585899 | Antibacterial activity against Streptococcus pneumoniae M87B overexpressing patA, patB and inactivated patB with single mutation by standardized agar doubling dilution method in presence of 20 ug/ml reserpine efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID585888 | Antibacterial activity against fluoroquinolone, dye-resistant Streptococcus pneumoniae M50 overexpressing patA, patB by standardized agar doubling dilution method in presence of 20 ug/ml reserpine efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID586097 | Antibacterial activity against fluoroquinolone, dye-resistant Streptococcus pneumoniae M45 overexpressing patA, patB by standardized agar doubling dilution method in presence of 50 uM sodium orthovanadate efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID532762 | Antimicrobial activity against Salmonella serovar Typhimurium SL1344 by broth dilution method in presence of chlorpromazine | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10
| RamA confers multidrug resistance in Salmonella enterica via increased expression of acrB, which is inhibited by chlorpromazine. |
| AID585708 | Antibacterial activity against fluoroquinolone, dye-resistant Streptococcus pneumoniae M297 overexpressing patA, patB by standardized agar doubling dilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID586106 | Antibacterial activity against fluoroquinolone, dye-resistant Streptococcus pneumoniae M86 overexpressing patA, patB by standardized agar doubling dilution method in presence of 50 uM sodium orthovanadate efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID585902 | Antibacterial activity against Streptococcus pneumoniae M310 overexpressing patA, patB and inactivated patB with single mutation by standardized agar doubling dilution method in presence of 20 ug/ml reserpine efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID585919 | Antibacterial activity against Streptococcus pneumoniae M315 overexpressing patA, patB and inactivated patA with single mutation by standardized agar doubling dilution method in presence of 20 ug/ml reserpine efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID388885 | DNA intercalative activity assessed retardation in migration of negatively supercoiled small circular Escherichia coli pBSKS in agarose gel electrophoresis at 100 uM | 2008 | Journal of medicinal chemistry, Nov-13, Volume: 51, Issue:21
| Design and synthesis of a novel series of pyranonaphthoquinones as topoisomerase II catalytic inhibitors. |
| AID472816 | Inhibition of HCV genotype 1b NS5B polymerase deltaC21 M423K mutant | 2010 | Bioorganic & medicinal chemistry, Apr-15, Volume: 18, Issue:8
| Allosteric inhibitors of hepatitis C virus NS5B polymerase thumb domain site II: structure-based design and synthesis of new templates. |
| AID1419492 | Binding affinity to calf thymus DNA by TLC plate based assay | 2017 | European journal of medicinal chemistry, May-05, Volume: 131 | Synthesis and biological evaluation of a new series of benzimidazole derivatives as antimicrobial, antiquorum-sensing and antitumor agents. |
| AID660265 | Antimicrobial activity against wild type Escherichia coli expressing AcrAB-TolC efflux pump | 2012 | European journal of medicinal chemistry, Jun, Volume: 52 | Computational analysis of structure-based interactions and ligand properties can predict efflux effects on antibiotics. |
| AID582815 | Antibacterial activity against dye-resistant Streptococcus pneumoniae M55 DR overexpressing patA, patB by standardized agar doubling dilution method in presence of 50 uM sodium orthovanadate efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID406646 | Antibacterial activity against Staphylococcus aureus ATCC 29213 after 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Dual targeting of DNA gyrase and topoisomerase IV: target interactions of heteroaryl isothiazolones in Staphylococcus aureus. |
| AID1362612 | Binding affinity to calf thymus DNA assessed as increase in viscosity at 15 uM by viscometric method | 2018 | Bioorganic & medicinal chemistry, 09-15, Volume: 26, Issue:17
| Synthesis of DNA interactive C3-trans-cinnamide linked β-carboline conjugates as potential cytotoxic and DNA topoisomerase I inhibitors. |
| AID532755 | Antimicrobial activity against Salmonella serovar Heidelberg 5171 by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10
| RamA confers multidrug resistance in Salmonella enterica via increased expression of acrB, which is inhibited by chlorpromazine. |
| AID405373 | Toxicity against human H9c2 cells assessed as inhibition of cell proliferation at 0.5 ug/ml after 6 days by SRB assay | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Absence of a universal mechanism of mitochondrial toxicity by nucleoside analogs. |
| AID1586738 | Inhibition of calf thymus topoisomerase-1-mediated relaxed pBR322 DNA unwinding at 25 uM preincubated with DNA for 10 mins followed by enzyme addition and measured after 30 mins by agarose gel electrophoresis assay | 2018 | Journal of natural products, 12-28, Volume: 81, Issue:12
| Eucalypglobulusals A-J, Formyl-Phloroglucinol-Terpene Meroterpenoids from Eucalyptus globulus Fruits. |
| AID585729 | Antibacterial activity against dye-resistant Streptococcus pneumoniae M46 DR overexpressing patA, patB by standardized agar doubling dilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID586104 | Antibacterial activity against Streptococcus pneumoniae M301 overexpressing patA, patB and inactivated patA with single mutation by standardized agar doubling dilution method in presence of 50 uM sodium orthovanadate efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID585706 | Antibacterial activity against Streptococcus pneumoniae M304 overexpressing patA, patB and inactivated patA with single mutation by standardized agar doubling dilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID1888846 | Antibacterial activity against Staphylococcus aureus 1199B measured after 24 hrs by Muller Hinton broth based MTT assay | 2022 | Bioorganic & medicinal chemistry, 01-15, Volume: 54 | Potentiating the intracellular killing of Staphylococcus aureus by dihydroquinazoline analogues as NorA efflux pump inhibitor. |
| AID678964 | TP_TRANSPORTER: uptake in BCRP-expressing Lactococcus lactis cells | 2003 | The Journal of biological chemistry, Jun-06, Volume: 278, Issue:23
| Sterol transport by the human breast cancer resistance protein (ABCG2) expressed in Lactococcus lactis. |
| AID585689 | Antibacterial activity against Streptococcus pneumoniae M298 overexpressing patA, patB and inactivated patB with single mutation by standardized agar doubling dilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID1356634 | Antimicrobial activity against mepA deficient Staphylococcus aureus SA-K2885 by microdilution method | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| 2-Phenylquinoline S. aureus NorA Efflux Pump Inhibitors: Evaluation of the Importance of Methoxy Group Introduction. |
| AID585892 | Antibacterial activity against Streptococcus pneumoniae M301 overexpressing patA, patB and inactivated patA with single mutation by standardized agar doubling dilution method in presence of 20 ug/ml reserpine efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID26756 | DNA binding dissociation constant as KD | 1984 | Journal of medicinal chemistry, Apr, Volume: 27, Issue:4
| Interactions of antitumor drugs with natural DNA: 1H NMR study of binding mode and kinetics. |
| AID582818 | Antibacterial activity against dye-resistant Streptococcus pneumoniae M46 DR overexpressing patA, patB by standardized agar doubling dilution method in presence of 50 uM sodium orthovanadate efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID520087 | Antimicrobial activity against acrAB-deficient Escherichia coli TG1 harboring AheABC efflux pump by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
| Role of the AheABC efflux pump in Aeromonas hydrophila intrinsic multidrug resistance. |
| AID1356632 | Antimicrobial activity against NorA deficient Staphylococcus aureus SA-K1902 by microdilution method | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| 2-Phenylquinoline S. aureus NorA Efflux Pump Inhibitors: Evaluation of the Importance of Methoxy Group Introduction. |
| AID585710 | Antibacterial activity against Streptococcus pneumoniae M311B overexpressing patA, patB and inactivated patB with single mutation by standardized agar doubling dilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID406658 | Antibacterial activity against Staphylococcus aureus ACH-0129 isolate with gyrA Ser84Leu, Glu88Val and grlA Ser80Phe, Ala116Val mutant after 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Dual targeting of DNA gyrase and topoisomerase IV: target interactions of heteroaryl isothiazolones in Staphylococcus aureus. |
| AID1594140 | Inhibition of Escherichia coli GroEL expressed in Escherichia coli DH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed as reduction in GroEL/GroES-mediated denatured rhodanese refolding by measuring rhodanese enzyme activity | 2019 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 29, Issue:9
| HSP60/10 chaperonin systems are inhibited by a variety of approved drugs, natural products, and known bioactive molecules. |
| AID405375 | Toxicity against human H9c2 cells assessed as elevation of lactate levels at 0.5 ug/ml after 6 days by NAD+ reduction assay | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Absence of a universal mechanism of mitochondrial toxicity by nucleoside analogs. |
| AID585707 | Antibacterial activity against Streptococcus pneumoniae M310 overexpressing patA, patB and inactivated patB with single mutation by standardized agar doubling dilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID585482 | Antibacterial activity against fluoroquinolone, dye-resistant Streptococcus pneumoniae by standardized agar doubling dilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID396282 | Antibacterial activity against drug-resistant AcrAB-TolC efflux pump deficient Enterobacter cloacae EcdeltaacrA isolate expressing pAP2 plasmid containing Enterobacter cloacae acrA gene by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9
| Cloning, nucleotide sequencing, and analysis of the AcrAB-TolC efflux pump of Enterobacter cloacae and determination of its involvement in antibiotic resistance in a clinical isolate. |
| AID405467 | Antibacterial activity against Escherichia coli TOP10 containing pAT851 plasmid by Etest | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Transferable resistance to aminoglycosides by methylation of G1405 in 16S rRNA and to hydrophilic fluoroquinolones by QepA-mediated efflux in Escherichia coli. |
| AID585683 | Antibacterial activity against fluoroquinolone, dye-susceptible Streptococcus pneumoniae by standardized agar doubling dilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID1502707 | Antimycobacterial activity against Mycobacterium avium 104 mc'2 3 assessed as reduction in bacterial viability incubated for 3 days by MTT assay | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Natural isoflavone biochanin A as a template for the design of new and potent 3-phenylquinolone efflux inhibitors against Mycobacterium avium. |
| AID1067699 | Inhibition of telomerase in human MGC803 cell extracts after 24 hrs by TRAP-PCR-ELISA | 2014 | European journal of medicinal chemistry, Mar-03, Volume: 74 | Novel coumarin-dihydropyrazole thio-ethanone derivatives: design, synthesis and anticancer activity. |
| AID586103 | Antibacterial activity against fluoroquinolone, dye-resistant Streptococcus pneumoniae M74 overexpressing patA, patB by standardized agar doubling dilution method in presence of 50 uM sodium orthovanadate efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID585681 | Antibacterial activity against dye-resistant Streptococcus pneumoniae by standardized agar doubling dilution method in presence of 20 ug/ml reserpine efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID585698 | Antibacterial activity against Streptococcus pneumoniae M305 overexpressing patA, patB and inactivated patB with single mutation by standardized agar doubling dilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID585908 | Antibacterial activity against Streptococcus pneumoniae M317 overexpressing patA, patB and inactivated patB with single mutation by standardized agar doubling dilution method in presence of 20 ug/ml reserpine efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID374689 | Antimicrobial activity against totarol-resistant Staphylococcus aureus K3090 | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
| The phenolic diterpene totarol inhibits multidrug efflux pump activity in Staphylococcus aureus. |
| AID406649 | Antibacterial activity against Staphylococcus aureus ACH-0221 isolate with gyrA Ser84Leu mutant after 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Dual targeting of DNA gyrase and topoisomerase IV: target interactions of heteroaryl isothiazolones in Staphylococcus aureus. |
| AID1428614 | Inhibition of recombinant human topoisomerase-1 assessed as DNA insertion by measuring drug-DNA-enzyme ternary complex formation up to 25 uM using supercoiled pBR322 DNA substrate after 30 mins by ethidium bromide staining based agarose gel electrophoresi | 2017 | European journal of medicinal chemistry, Feb-15, Volume: 127 | Novel 4-(4-substituted amidobenzyl)furan-2(5H)-one derivatives as topoisomerase I inhibitors. |
| AID532584 | Antimicrobial activity against Salmonella serovar Enteritidis 5188 by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10
| RamA confers multidrug resistance in Salmonella enterica via increased expression of acrB, which is inhibited by chlorpromazine. |
| AID586114 | Antibacterial activity against Streptococcus pneumoniae M310 overexpressing patA, patB and inactivated patB with single mutation by standardized agar doubling dilution method in presence of 50 uM sodium orthovanadate efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID585691 | Antibacterial activity against Streptococcus pneumoniae M45A overexpressing patA, patB and inactivated patA with single mutation by standardized agar doubling dilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID1339146 | Binding affinity to synthetic biotin-labeled 30-mer AT-rich duplex DNA in pH 7.8 Tris-Hcl buffer solution assessed as dissociation rate constant in presence of 0.1 M NaCl at 25 degC by QCM sensogram analysis | 2017 | Bioorganic & medicinal chemistry, 02-01, Volume: 25, Issue:3
| Determination of binding modes and binding constants for the complexes of 6H-pyrido[4,3-b]carbazole derivatives with DNA. |
| AID1594139 | Inhibition of human N-terminal octa-His-tagged HSP60 expressed in Escherichia coli Rosetta(DE3) pLysS/human HSP10 expressed in Escherichia coli Rosetta(DE3) assessed as reduction in HSP60/HSP10-mediated denatured MDH refolding by measuring MDH enzyme acti | 2019 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 29, Issue:9
| HSP60/10 chaperonin systems are inhibited by a variety of approved drugs, natural products, and known bioactive molecules. |
| AID406812 | Antibacterial activity against Staphylococcus aureus BSA678 isolate with gyrA Ser84Leu, Ser85Pro and grlA Ser80Phe, Glu84Gly mutant after 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Dual targeting of DNA gyrase and topoisomerase IV: target interactions of heteroaryl isothiazolones in Staphylococcus aureus. |
| AID585712 | Antibacterial activity against Streptococcus pneumoniae M316 overexpressing patA, patB and inactivated patA with single mutation by standardized agar doubling dilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID472813 | Antiviral activity against Hepatitis C virus H2B2 | 2010 | Bioorganic & medicinal chemistry, Apr-15, Volume: 18, Issue:8
| Allosteric inhibitors of hepatitis C virus NS5B polymerase thumb domain site II: structure-based design and synthesis of new templates. |
| AID585727 | Antibacterial activity against Streptococcus pneumoniae M300 overexpressing patA, patB and inactivated patA with single mutation by standardized agar doubling dilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID585703 | Antibacterial activity against Streptococcus pneumoniae M87A overexpressing patA, patB and inactivated patA with single mutation by standardized agar doubling dilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID243248 | Ratio of maximum concentration bound and specificity sum for triplex nucleic acids | 2004 | Journal of medicinal chemistry, Nov-04, Volume: 47, Issue:23
| Structural selectivity of aromatic diamidines. |
| AID1191411 | Inhibition of telomerase in human MGC803 cells after 24 hrs by TRAP-PCR-ELISA | 2015 | European journal of medicinal chemistry, Jan-27, Volume: 90 | Novel pyrazole-5-carboxamide and pyrazole-pyrimidine derivatives: synthesis and anticancer activity. |
| AID519833 | Antimicrobial activity against Aeromonas hydrophila subsp. hydrophila ATCC 7966 harboring plasmid pEX19Gm by agar dilution method in presence of 64 mg/L efflux pump inhibitor phenylalanine-arginine-beta-naphthylamide | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
| Role of the AheABC efflux pump in Aeromonas hydrophila intrinsic multidrug resistance. |
| AID516696 | Inhibition of telomerase in human SGC7901 cells by TRAP assay | 2010 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 20, Issue:19
| Synthesis and molecular docking study of novel coumarin derivatives containing 4,5-dihydropyrazole moiety as potential antitumor agents. |
| AID1363348 | Binding affinity to Escherichia coli supercoiled pBR322 DNA assessed as TOP1-mediated unwinding effect at 0.3 to 1.2 ug/ml preincubated for 10 mins followed by TOP1 addition and measured after 30 mins by agarose gel electrophoresis | 2018 | Journal of medicinal chemistry, 11-21, Volume: 61, Issue:22
| Discovery, Synthesis, and Evaluation of Oxynitidine Derivatives as Dual Inhibitors of DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1), and Potential Antitumor Agents. |
| AID405368 | Toxicity against human H9c2 cells assessed as reduction in mitochondrial DNA copy numbers at 0.5 ug/ml after 6 days relative to control | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Absence of a universal mechanism of mitochondrial toxicity by nucleoside analogs. |
| AID31893 | Thermal denaturation in sonicated poly(dA)-poly(dT) homopolymer (AT) | 1993 | Journal of medicinal chemistry, Jun-11, Volume: 36, Issue:12
| Structure, DNA minor groove binding, and base pair specificity of alkyl- and aryl-linked bis(amidinobenzimidazoles) and bis(amidinoindoles). |
| AID406657 | Antibacterial activity against Staphylococcus aureus ACH-0129 isolate with gyrA Ser84Leu, Glu88Val and grlA Ser80Phe, Ala116Val mutant after 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Dual targeting of DNA gyrase and topoisomerase IV: target interactions of heteroaryl isothiazolones in Staphylococcus aureus. |
| AID585685 | Antibacterial activity against fluoroquinolone, dye-susceptible Streptococcus pneumoniae by standardized agar doubling dilution method in presence of 50 uM sodium orthovanadate efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID585493 | Antibacterial activity against fluoroquinolone-resistant Streptococcus pneumoniae by standardized agar doubling dilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID339751 | Binding affinity to synthetic poly(dA-dT):poly(dA-dT) DNA: DNA duplex assessed as melting temperature at 2.2 uM | 2008 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 18, Issue:14
| Molecular recognition of a DNA:RNA hybrid: sub-nanomolar binding by a neomycin-methidium conjugate. |
| AID572156 | Activity of Neisseria gonorrhoeae FA19 multidrug efflux protein NorM expressed in Escherichia coli AG100AX assessed as reduction in compound accumulation in presence of 100 mM NaCl by fluorimetric assay | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| Functional cloning and characterization of the multidrug efflux pumps NorM from Neisseria gonorrhoeae and YdhE from Escherichia coli. |
| AID405456 | Antibacterial activity against Escherichia coli C600Rif in presence of 40 ug/ml efflux pump inhibitor 1-(1-naphthylmethyl)-piperazine by Etest | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Transferable resistance to aminoglycosides by methylation of G1405 in 16S rRNA and to hydrophilic fluoroquinolones by QepA-mediated efflux in Escherichia coli. |
| AID366770 | Inhibition of calf thymus topoisomerase 1-mediated supercoiled plasmid pCI DNA relaxation activity at 10 uM after 30 mins by gel electrophoresis | 2008 | Journal of medicinal chemistry, Aug-28, Volume: 51, Issue:16
| Novel amidino-substituted thienyl- and furylvinylbenzimidazole: derivatives and their photochemical conversion into corresponding diazacyclopenta[c]fluorenes. synthesis, interactions with DNA and RNA, and antitumor evaluation. 4. |
| AID585715 | Antibacterial activity against Streptococcus pneumoniae M318 overexpressing patA, patB and inactivated patA with single mutation by standardized agar doubling dilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID585494 | Antibacterial activity against fluoroquinolone-resistant Streptococcus pneumoniae by standardized agar doubling dilution method in presence of 20 ug/ml reserpine efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID585916 | Antibacterial activity against Streptococcus pneumoniae M314 overexpressing patA, patB and inactivated patA with single mutation by standardized agar doubling dilution method in presence of 20 ug/ml reserpine efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID586108 | Antibacterial activity against Streptococcus pneumoniae M86B overexpressing patA, patB and inactivated patB with single mutation by standardized agar doubling dilution method in presence of 50 uM sodium orthovanadate efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID406652 | Antibacterial activity against Staphylococcus aureus ACH-0126 isolate with gyrA Ser84Leu and grlA Ser80Phe mutant after 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Dual targeting of DNA gyrase and topoisomerase IV: target interactions of heteroaryl isothiazolones in Staphylococcus aureus. |
| AID586112 | Antibacterial activity against fluoroquinolone, dye-resistant Streptococcus pneumoniae M296 overexpressing patA, patB by standardized agar doubling dilution method in presence of 50 uM sodium orthovanadate efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID586111 | Antibacterial activity against Streptococcus pneumoniae M87B overexpressing patA, patB and inactivated patB with single mutation by standardized agar doubling dilution method in presence of 50 uM sodium orthovanadate efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID585893 | Antibacterial activity against Streptococcus pneumoniae M305 overexpressing patA, patB and inactivated patB with single mutation by standardized agar doubling dilution method in presence of 20 ug/ml reserpine efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID285528 | Antibacterial activity against ethidium bromide-resistant Staphylococcus aureus ATCC 29213 after 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4
| In vitro and in vivo antibacterial activities of heteroaryl isothiazolones against resistant gram-positive pathogens. |
| AID1326610 | Inhibition of calf thymus DNA topoisomerase 1 assessed as DNA-insertion by measuring reduction in conversion of negatively supercoiled pBR322 plasmid DNA to relaxed DNA at 25 uM preincubated followed by substrate addition measured after 30 mins by ethidiu | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Novel securinine derivatives as topoisomerase I based antitumor agents. |
| AID520084 | Antimicrobial activity against Escherichia coli TG1 harboring plasmid pEX19Gm by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
| Role of the AheABC efflux pump in Aeromonas hydrophila intrinsic multidrug resistance. |
| AID576019 | Antimicrobial activity against Staphylococcus aureus RDN1 harboring cloned pTZ2238-encoded QacBIV gene by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10
| Fluoroquinolone efflux by the plasmid-mediated multidrug efflux pump QacB variant QacBIII in Staphylococcus aureus. |
| AID585696 | Antibacterial activity against fluoroquinolone, dye-resistant Streptococcus pneumoniae M74 overexpressing patA, patB by standardized agar doubling dilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID585884 | Antibacterial activity against Streptococcus pneumoniae M298 overexpressing patA, patB and inactivated patB with single mutation by standardized agar doubling dilution method in presence of 20 ug/ml reserpine efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID1060709 | Cytotoxicity against mouse NIH/3T3 cells after 24 hrs by MTT assay | 2014 | Bioorganic & medicinal chemistry, Jan-01, Volume: 22, Issue:1
| Synthesis, molecular modeling and biological evaluation of N-benzylidene-2-((5-(pyridin-4-yl)-1,3,4-oxadiazol-2-yl)thio)acetohydrazide derivatives as potential anticancer agents. |
| AID1855985 | Binding affinity to DNA (unknown origin) assessed as DNA intercalation at 1 ug/ml by measuring amount of methyl green dye replaced from DNA-methyl green complex | | | |
| AID586116 | Antibacterial activity against Streptococcus pneumoniae M311 overexpressing patA, patB and inactivated patA with single mutation by standardized agar doubling dilution method in presence of 50 uM sodium orthovanadate efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID405460 | Antibacterial activity against Escherichia coli C600Rif containing pIP1206 plasmid in presence of 50 ug/ml efflux pump inhibitor phenyl-arginine-beta-naphthylamide by Etest | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Transferable resistance to aminoglycosides by methylation of G1405 in 16S rRNA and to hydrophilic fluoroquinolones by QepA-mediated efflux in Escherichia coli. |
| AID498874 | Antimicrobial activity against Neisseria meningitidis M7tolC::Kan by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1
| Biologic activities of the TolC-like protein of Neisseria meningitidis as assessed by functional complementation in Escherichia coli. |
| AID1632796 | Binding affinity to calf thymus duplex DNA assessed as induction of ellipticity at 2.5 to 63 uM in pH 7 phosphate buffer by circular dichroism method | 2016 | Bioorganic & medicinal chemistry letters, 10-01, Volume: 26, Issue:19
| DNA-binding studies of the natural β-carboline eudistomin U. |
| AID1502711 | Antimycobacterial activity against Mycobacterium avium isolate MAV2 assessed as reduction in bacterial viability incubated for 3 days by MTT assay | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Natural isoflavone biochanin A as a template for the design of new and potent 3-phenylquinolone efflux inhibitors against Mycobacterium avium. |
| AID405454 | Antibacterial activity against Escherichia coli C600Rif by Etest | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Transferable resistance to aminoglycosides by methylation of G1405 in 16S rRNA and to hydrophilic fluoroquinolones by QepA-mediated efflux in Escherichia coli. |
| AID361640 | Inhibition of calf thymus topoisomerase 1 assessed as induction of supercoiled plasmid pCI DNA nicking at 10 uM after 30 mins by gel electrophoresis | 2008 | Journal of medicinal chemistry, Aug-28, Volume: 51, Issue:16
| Novel amidino-substituted thienyl- and furylvinylbenzimidazole: derivatives and their photochemical conversion into corresponding diazacyclopenta[c]fluorenes. synthesis, interactions with DNA and RNA, and antitumor evaluation. 4. |
| AID405374 | Toxicity against human HepG2/C3A cells assessed as elevation of lactate levels at 0.5 ug/ml after 6 days by NAD+ reduction assay | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Absence of a universal mechanism of mitochondrial toxicity by nucleoside analogs. |
| AID585695 | Antibacterial activity against Streptococcus pneumoniae M50B overexpressing patA, patB and inactivated patB with single mutation by standardized agar doubling dilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID406653 | Antibacterial activity against Staphylococcus aureus ACH-0210 isolate with gyrA Ser84Leu and grlA Ser80Phe mutant after 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Dual targeting of DNA gyrase and topoisomerase IV: target interactions of heteroaryl isothiazolones in Staphylococcus aureus. |
| AID585881 | Antibacterial activity against fluoroquinolone, dye-resistant Streptococcus pneumoniae R6 by standardized agar doubling dilution method in presence of 20 ug/ml reserpine efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID585725 | Antibacterial activity against Streptococcus pneumoniae M308 overexpressing patA, patB and inactivated patB with single mutation by standardized agar doubling dilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID586107 | Antibacterial activity against Streptococcus pneumoniae M86A overexpressing patA, patB and inactivated patA with single mutation by standardized agar doubling dilution method in presence of 50 uM sodium orthovanadate efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID396284 | Antibacterial activity against drug-resistant AcrAB-TolC efflux pump deficient Enterobacter cloacae EcdeltaacrA isolate expressing pAP3 plasmid containing Enterobacter aerogenes acrR gene by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9
| Cloning, nucleotide sequencing, and analysis of the AcrAB-TolC efflux pump of Enterobacter cloacae and determination of its involvement in antibiotic resistance in a clinical isolate. |
| AID1586737 | Inhibition of calf thymus topoisomerase-1-mediated supercoiled pBR322 DNA unwinding at 25 uM preincubated with DNA for 10 mins followed by enzyme addition and measured after 30 mins by agarose gel electrophoresis assay | 2018 | Journal of natural products, 12-28, Volume: 81, Issue:12
| Eucalypglobulusals A-J, Formyl-Phloroglucinol-Terpene Meroterpenoids from Eucalyptus globulus Fruits. |
| AID1493962 | Binding affinity to calf thymus double stranded DNA at 5 uM by ostwald viscometer | 2018 | European journal of medicinal chemistry, Jan-01, Volume: 143 | Design, synthesis and biological evaluation of new β-carboline-bisindole compounds as DNA binding, photocleavage agents and topoisomerase I inhibitors. |
| AID523171 | Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate OC11521 harboring gyrA S84L/S85P, parC E84G mutant gene assessed as >= 4 fold increase in bactericidal activity by broth microdilution method in presence of 20 ug/ml reserp | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| In vitro antibacterial activities of JNJ-Q2, a new broad-spectrum fluoroquinolone. |
| AID1326457 | Binding affinity to calf thymus DNA assessed as DNA intercalation by measuring conformational changes at 100 uM after 2 hrs by CD spectroscopic analysis | 2016 | European journal of medicinal chemistry, Oct-21, Volume: 122 | Scaffold-hopping of bioactive flavonoids: Discovery of aryl-pyridopyrimidinones as potent anticancer agents that inhibit catalytic role of topoisomerase IIα. |
| AID586122 | Antibacterial activity against Streptococcus pneumoniae M318 overexpressing patA, patB and inactivated patA with single mutation by standardized agar doubling dilution method in presence of 50 uM sodium orthovanadate efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID762417 | Antimicrobial activity against Mycobacterium smegmatis MC2 155 ATCC 700084 after 72 hrs by MTT assay | 2013 | European journal of medicinal chemistry, Aug, Volume: 66 | 7-Hydroxy-(E)-3-phenylmethylene-chroman-4-one analogues as efflux pump inhibitors against Mycobacterium smegmatis mc² 155. |
| AID585484 | Antibacterial activity against wild type Streptococcus pneumoniae M4 NCTC 7465 type 1 by standardized agar doubling dilution method in presence of 50 uM sodium orthovanadate efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID285529 | Antibacterial activity against ethidium bromide-resistant Staphylococcus aureus ATCC 29213 in presence of 20 ug/ml reserpine after 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4
| In vitro and in vivo antibacterial activities of heteroaryl isothiazolones against resistant gram-positive pathogens. |
| AID585485 | Antibacterial activity against wild type Streptococcus pneumoniae M3 NCTC 7466 type 2 by standardized agar doubling dilution method in presence of 50 uM sodium orthovanadate efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID54984 | Thermal denaturation in sonicated calf thymus DNA (CT DNA) | 1993 | Journal of medicinal chemistry, Jun-11, Volume: 36, Issue:12
| Structure, DNA minor groove binding, and base pair specificity of alkyl- and aryl-linked bis(amidinobenzimidazoles) and bis(amidinoindoles). |
| AID977602 | Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM | 2013 | Molecular pharmacology, Jun, Volume: 83, Issue:6
| Structure-based identification of OATP1B1/3 inhibitors. |
| AID1549672 | Binding affinity to Escherichia coli supercoiled pBR322 DNA assessed as DNA intercalation at 5 uM after 3 hrs by ethidium bromide staining-based agarose gel electrophoresis analysis | 2019 | European journal of medicinal chemistry, May-01, Volume: 169 | Cryptolepine and aromathecin based mimics as potent G-quadruplex-binding, DNA-cleavage and anticancer agents: Design, synthesis and DNA targeting-induced apoptosis. |
| AID582819 | Antibacterial activity against Streptococcus pneumoniae M46A overexpressing patA, patB and inactivated patA with single mutation by standardized agar doubling dilution method in presence of 50 uM sodium orthovanadate efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID1273398 | Anti-tubercular activity against Mycobacterium tuberculosis H37Rv ATCC 27294T after 7 days by mircodilution method | 2016 | European journal of medicinal chemistry, Jan-01, Volume: 107 | Hybrid triazoles: Design and synthesis as potential dual inhibitor of growth and efflux inhibition in tuberculosis. |
| AID489406 | Inhibition of human telomerase in human SGC7901 cells by TRAP assay | 2010 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 20, Issue:14
| Synthesis and molecular docking studies of novel 2-chloro-pyridine derivatives containing flavone moieties as potential antitumor agents. |
| AID586095 | Antibacterial activity against Streptococcus pneumoniae M298 overexpressing patA, patB and inactivated patA with single mutation by standardized agar doubling dilution method in presence of 50 uM sodium orthovanadate efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID584115 | Antibacterial activity against Escherichia coli KAM32 harboring pSP72 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12
| LmrS is a multidrug efflux pump of the major facilitator superfamily from Staphylococcus aureus. |
| AID532580 | Antimicrobial activity against Salmonella serovar Typhimurium SL1344 expressing ramA::aph mutant by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10
| RamA confers multidrug resistance in Salmonella enterica via increased expression of acrB, which is inhibited by chlorpromazine. |
| AID585688 | Antibacterial activity against Streptococcus pneumoniae M298 overexpressing patA, patB and inactivated patA with single mutation by standardized agar doubling dilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID585716 | Antibacterial activity against Streptococcus pneumoniae M319 overexpressing patA, patB and inactivated patB with single mutation by standardized agar doubling dilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID406647 | Antibacterial activity against Staphylococcus aureus ACH-0204 isolate with gyrA Ser84Leu mutant after 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Dual targeting of DNA gyrase and topoisomerase IV: target interactions of heteroaryl isothiazolones in Staphylococcus aureus. |
| AID585921 | Antibacterial activity against dye-resistant Streptococcus pneumoniae M55 DR overexpressing patA, patB by standardized agar doubling dilution method in presence of 20 ug/ml reserpine efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID1356633 | Antimicrobial activity against NorA overexpressing Staphylococcus aureus SA-K2378 by microdilution method | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| 2-Phenylquinoline S. aureus NorA Efflux Pump Inhibitors: Evaluation of the Importance of Methoxy Group Introduction. |
| AID406808 | Antibacterial activity against Staphylococcus aureus ATCC 33591 isolate after 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Dual targeting of DNA gyrase and topoisomerase IV: target interactions of heteroaryl isothiazolones in Staphylococcus aureus. |
| AID532759 | Antimicrobial activity against Salmonella serovar Montevideo 5747 by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10
| RamA confers multidrug resistance in Salmonella enterica via increased expression of acrB, which is inhibited by chlorpromazine. |
| AID582822 | Antibacterial activity against Streptococcus pneumoniae M303 overexpressing patA, patB and inactivated patA with single mutation by standardized agar doubling dilution method in presence of 50 uM sodium orthovanadate efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID576017 | Antimicrobial activity against Staphylococcus aureus RDN1 harboring cloned pTZ2162-encoded QacBIII gene by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10
| Fluoroquinolone efflux by the plasmid-mediated multidrug efflux pump QacB variant QacBIII in Staphylococcus aureus. |
| AID585684 | Antibacterial activity against fluoroquinolone, dye-susceptible Streptococcus pneumoniae by standardized agar doubling dilution method in presence of 20 ug/ml reserpine efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID585723 | Antibacterial activity against fluoroquinolone-resistant Streptococcus pneumoniae M100 FQ-R overexpressing patA, patB by standardized agar doubling dilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID520085 | Antimicrobial activity against acrAB-deficient Escherichia coli TG1 harboring plasmid pEX19Gm by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
| Role of the AheABC efflux pump in Aeromonas hydrophila intrinsic multidrug resistance. |
| AID405369 | Toxicity in human HepG2/C3A cells assessed as cell viability at 0.5 ug/ml after 10 days | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Absence of a universal mechanism of mitochondrial toxicity by nucleoside analogs. |
| AID1594141 | Inhibition of Escherichia coli GroEL expressed in Escherichia coliDH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed as reduction in GroEL/GroES-mediated denatured soluble pig heart MDH refolding by measuring MDH enzyme acti | 2019 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 29, Issue:9
| HSP60/10 chaperonin systems are inhibited by a variety of approved drugs, natural products, and known bioactive molecules. |
| AID759750 | Binding affinity to DNA (unknown origin) assessed as induction of conformational changes at 300 uM after 2 hrs by CD spectrometric analysis | 2013 | Journal of medicinal chemistry, Jul-25, Volume: 56, Issue:14
| Mahanine, a DNA minor groove binding agent exerts cellular cytotoxicity with involvement of C-7-OH and -NH functional groups. |
| AID285530 | Antibacterial activity against ethidium bromide-resistant Staphylococcus aureus Mu50 after 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4
| In vitro and in vivo antibacterial activities of heteroaryl isothiazolones against resistant gram-positive pathogens. |
| AID743749 | Binding affinity to DNA (unknown origin) at 5 mg/mL by RP-TLC plate analysis | 2013 | European journal of medicinal chemistry, May, Volume: 63 | Synthesis, in vitro antitumor evaluation and DNA-binding study of novel tetrahydroquinolines and some derived tricyclic and tetracyclic ring systems. |
| AID339764 | Binding affinity to synthetic poly(dA):poly(rU) DNA:RNA hybrid assessed as association constant at 20 degC | 2008 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 18, Issue:14
| Molecular recognition of a DNA:RNA hybrid: sub-nanomolar binding by a neomycin-methidium conjugate. |
| AID532757 | Antimicrobial activity against Salmonella serovar Kedougou by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10
| RamA confers multidrug resistance in Salmonella enterica via increased expression of acrB, which is inhibited by chlorpromazine. |
| AID725721 | Inhibition of telomerase-mediated supercoiling activity in human MGC803 cells after 24 hrs by TRAP-PCR-ELISA assay | 2013 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 23, Issue:3
| Design and synthesis of novel 2-methyl-4,5-substitutedbenzo[f]-3,3a,4,5-tetrahydro-pyrazolo[1,5-d][1,4]oxazepin-8(7H)-one derivatives as telomerase inhibitors. |
| AID572147 | Antimicrobial activity against AcrAB-deficient Escherichia coli AG100AX harboring pBADomeganorM plasmid containing Neisseria gonorrhoeae multidrug efflux pump NorM after 18 to 24 hrs by two fold dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| Functional cloning and characterization of the multidrug efflux pumps NorM from Neisseria gonorrhoeae and YdhE from Escherichia coli. |
| AID406656 | Antibacterial activity against Staphylococcus aureus ACH-0203 isolate with gyrA Ser84Leu and grlA Ser80Phe, Ala116Val mutant after 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Dual targeting of DNA gyrase and topoisomerase IV: target interactions of heteroaryl isothiazolones in Staphylococcus aureus. |
| AID582813 | Antibacterial activity against Streptococcus pneumoniae M315 overexpressing patA, patB and inactivated patA with single mutation by standardized agar doubling dilution method in presence of 50 uM sodium orthovanadate efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID702826 | Induction of DNA intercalation in Escherichia coli pBR322 DNA assessed as induction of supercoiled DNA at 1 ug/ml incubated for 15 mins by electrophoresis based Top1 unwinding assay | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| New tricks for an old natural product: discovery of highly potent evodiamine derivatives as novel antitumor agents by systemic structure-activity relationship analysis and biological evaluations. |
| AID585724 | Antibacterial activity against Streptococcus pneumoniae M315 overexpressing patA, patB and inactivated patA with single mutation by standardized agar doubling dilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID576016 | Antimicrobial activity against Staphylococcus aureus RDN1 harboring cloned pTZ2182-encoded QacBII gene by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10
| Fluoroquinolone efflux by the plasmid-mediated multidrug efflux pump QacB variant QacBIII in Staphylococcus aureus. |
| AID681211 | TP_TRANSPORTER: growth inhibition in BCRP-expressing Lactococcus lactis cells | 2003 | The Journal of biological chemistry, Jun-06, Volume: 278, Issue:23
| Sterol transport by the human breast cancer resistance protein (ABCG2) expressed in Lactococcus lactis. |
| AID1594137 | Inhibition of ATPase activity of Escherichia coli GroEL expressed in Escherichia coliDH5alpha incubated for 60 mins using ATP by spectrometric analysis | 2019 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 29, Issue:9
| HSP60/10 chaperonin systems are inhibited by a variety of approved drugs, natural products, and known bioactive molecules. |
| AID572158 | Binding affinity to Escherichia coli K-12 multidrug efflux protein YdhE expressed in Escherichia coli AG100AX in presence of 0.02% DDM surfactant by fluorescence polarization assay | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| Functional cloning and characterization of the multidrug efflux pumps NorM from Neisseria gonorrhoeae and YdhE from Escherichia coli. |
| AID586115 | Antibacterial activity against fluoroquinolone, dye-resistant Streptococcus pneumoniae M297 overexpressing patA, patB by standardized agar doubling dilution method in presence of 50 uM sodium orthovanadate efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID585904 | Antibacterial activity against Streptococcus pneumoniae M311 overexpressing patA, patB and inactivated patA with single mutation by standardized agar doubling dilution method in presence of 20 ug/ml reserpine efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID339765 | Binding affinity to synthetic poly(rA):poly(rU) DNA:RNA hybrid assessed as association constant at 20 degC | 2008 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 18, Issue:14
| Molecular recognition of a DNA:RNA hybrid: sub-nanomolar binding by a neomycin-methidium conjugate. |
| AID532758 | Antimicrobial activity against Salmonella serovar Mbandaka 7892 by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10
| RamA confers multidrug resistance in Salmonella enterica via increased expression of acrB, which is inhibited by chlorpromazine. |
| AID585905 | Antibacterial activity against Streptococcus pneumoniae M311B overexpressing patA, patB and inactivated patB with single mutation by standardized agar doubling dilution method in presence of 20 ug/ml reserpine efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID406810 | Antibacterial activity against Staphylococcus aureus ATCC 700699 isolate with gyrA Ser84Leu, Glu409Lys and grlA Ser80Phe mutant after 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Dual targeting of DNA gyrase and topoisomerase IV: target interactions of heteroaryl isothiazolones in Staphylococcus aureus. |
| AID576021 | Antimicrobial activity against Staphylococcus aureus RDN1 harboring cloned pTZ2238-encoded QacBIV S151I mutant gene by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10
| Fluoroquinolone efflux by the plasmid-mediated multidrug efflux pump QacB variant QacBIII in Staphylococcus aureus. |
| AID585705 | Antibacterial activity against fluoroquinolone, dye-resistant Streptococcus pneumoniae M296 overexpressing patA, patB by standardized agar doubling dilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID283559 | Antibacterial activity against Escherichia coli AG102MB after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3
| Substrate competition studies using whole-cell accumulation assays with the major tripartite multidrug efflux pumps of Escherichia coli. |
| AID585701 | Antibacterial activity against Streptococcus pneumoniae M86B overexpressing patA, patB and inactivated patB with single mutation by standardized agar doubling dilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID374690 | Antimicrobial activity against Staphylococcus aureus K3092 overexpressing NorA gene | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
| The phenolic diterpene totarol inhibits multidrug efflux pump activity in Staphylococcus aureus. |
| AID1502709 | Antimycobacterial activity against Mycobacterium avium ATCC 25291 assessed as reduction in bacterial viability incubated for 3 days by MTT assay | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Natural isoflavone biochanin A as a template for the design of new and potent 3-phenylquinolone efflux inhibitors against Mycobacterium avium. |
| AID1859834 | Displacement of methyl green from salmon sperm DNA at 10 uM measured after 2 hrs by fluorescence plate reader method relative to control | 2022 | European journal of medicinal chemistry, Aug-05, Volume: 238 | Novel hybrid pyrrolidinedione-thiazolidinones as potential anticancer agents: Synthesis and biological evaluation. |
| AID585915 | Antibacterial activity against fluoroquinolone-resistant Streptococcus pneumoniae M98 FQ-R overexpressing patA, patB by standardized agar doubling dilution method in presence of 20 ug/ml reserpine efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID585495 | Antibacterial activity against fluoroquinolone-resistant Streptococcus pneumoniae by standardized agar doubling dilution method in presence of 50 uM sodium orthovanadate efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID368421 | Antimicrobial activity against Escherichia coli KAM32 pSTV28 containing chloramphenicol-resistant vector by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9
| New plasmid-mediated fluoroquinolone efflux pump, QepA, found in an Escherichia coli clinical isolate. |
| AID585481 | Antibacterial activity against fluoroquinolone, dye-resistant Streptococcus pneumoniae by standardized agar doubling dilution method in presence of 20 ug/ml reserpine efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID586120 | Antibacterial activity against Streptococcus pneumoniae M317 overexpressing patA, patB and inactivated patB with single mutation by standardized agar doubling dilution method in presence of 50 uM sodium orthovanadate efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID639399 | Binding affinity to calf thymus DNA assessed as intercalation measuring viscosity index at compound to DNA molar ratio of 0.2 at pH 7 by viscometry method | 2011 | Bioorganic & medicinal chemistry, Nov-01, Volume: 19, Issue:21
| Novel biologically active nitro and amino substituted benzimidazo[1,2-a]quinolines. |
| AID285533 | Antibacterial activity against ethidium bromide-resistant Staphylococcus aureus BSA678 after 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4
| In vitro and in vivo antibacterial activities of heteroaryl isothiazolones against resistant gram-positive pathogens. |
| AID1060710 | Inhibition of telomerase in human SW1116 cells after 24 hrs by TRAP-PCR-ELISA assay | 2014 | Bioorganic & medicinal chemistry, Jan-01, Volume: 22, Issue:1
| Synthesis, molecular modeling and biological evaluation of N-benzylidene-2-((5-(pyridin-4-yl)-1,3,4-oxadiazol-2-yl)thio)acetohydrazide derivatives as potential anticancer agents. |
| AID586126 | Antibacterial activity against Streptococcus pneumoniae M306 overexpressing patA, patB and inactivated patB with single mutation by standardized agar doubling dilution method in presence of 50 uM sodium orthovanadate efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID248000 | Concentration required to inhibit 50% of human carcinoma A2780 cell lines | 2004 | Bioorganic & medicinal chemistry letters, Dec-06, Volume: 14, Issue:23
| Evaluation of by disubstituted acridone derivatives as telomerase inhibitors: the importance of G-quadruplex binding. |
| AID532583 | Antimicrobial activity against Salmonella serovar Binza 8269 by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10
| RamA confers multidrug resistance in Salmonella enterica via increased expression of acrB, which is inhibited by chlorpromazine. |
| AID534106 | Antibacterial activity against Pasteurella multocida AL435 after 24 hrs by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11
| Characterization of TolC efflux pump proteins from Pasteurella multocida. |
| AID582812 | Antibacterial activity against fluoroquinolone-resistant Streptococcus pneumoniae M100 FQ-R overexpressing patA, patB by standardized agar doubling dilution method in presence of 50 uM sodium orthovanadate efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID212907 | Inhibitory activity against telomerase (Compound released from DNA/DNA heteroduplex derivatized resin [sequence (TTAGGG)3) | 2001 | Bioorganic & medicinal chemistry letters, Oct-22, Volume: 11, Issue:20
| Small molecule/nucleic acid affinity chromatography: application for the identification of telomerase inhibitors which target its key RNA/DNA heteroduplex. |
| AID576022 | Antimicrobial activity against Staphylococcus aureus RDN1 harboring cloned pTZ2238-encoded QacBIV A184V mutant gene by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10
| Fluoroquinolone efflux by the plasmid-mediated multidrug efflux pump QacB variant QacBIII in Staphylococcus aureus. |
| AID582821 | Antibacterial activity against fluoroquinolone, dye-susceptible Streptococcus pneumoniae M295 S overexpressing patA, patB by standardized agar doubling dilution method in presence of 50 uM sodium orthovanadate efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID585887 | Antibacterial activity against Streptococcus pneumoniae M45B overexpressing patA, patB and inactivated patB with single mutation by standardized agar doubling dilution method in presence of 20 ug/ml reserpine efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID212908 | Inhibitory activity against telomerase (Compound released from RNA/DNA heteroduplex derivatized resin [sequence (TTAGGG)3) | 2001 | Bioorganic & medicinal chemistry letters, Oct-22, Volume: 11, Issue:20
| Small molecule/nucleic acid affinity chromatography: application for the identification of telomerase inhibitors which target its key RNA/DNA heteroduplex. |
| AID523165 | Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate OC8525 harboring wild type quinolone resistance-determining region assessed as >= 4 fold increase in bactericidal activity by broth microdilution method in presence of 20 u | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| In vitro antibacterial activities of JNJ-Q2, a new broad-spectrum fluoroquinolone. |
| AID405371 | Toxicity in human sH9c2 cells assessed as cell viability at 0.5 ug/ml after 10 to 14 days | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Absence of a universal mechanism of mitochondrial toxicity by nucleoside analogs. |
| AID1356627 | Cytotoxicity in human THP1 cells assessed as reduction in cell viability incubated for 24 hrs by ATP bioluminescence assay | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| 2-Phenylquinoline S. aureus NorA Efflux Pump Inhibitors: Evaluation of the Importance of Methoxy Group Introduction. |
| AID519834 | Antimicrobial activity against aheB deficient kanamycin-resistant Aeromonas hydrophila subsp. hydrophila ATCC 7966 harboring plasmid pEX19Gm by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
| Role of the AheABC efflux pump in Aeromonas hydrophila intrinsic multidrug resistance. |
| AID585486 | Antibacterial activity against wild type Streptococcus pneumoniae R6 by standardized agar doubling dilution method in presence of 20 ug/ml reserpine efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID585918 | Antibacterial activity against fluoroquinolone-resistant Streptococcus pneumoniae M100 FQ-R overexpressing patA, patB by standardized agar doubling dilution method in presence of 20 ug/ml reserpine efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID585914 | Antibacterial activity against Streptococcus pneumoniae M306 overexpressing patA, patB and inactivated patB with single mutation by standardized agar doubling dilution method in presence of 20 ug/ml reserpine efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID585702 | Antibacterial activity against fluoroquinolone, dye-resistant Streptococcus pneumoniae M87 overexpressing patA, patB by standardized agar doubling dilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID510747 | Antibacterial activity against Escherichia coli AG102MB harboring pSport1-based acrB gene | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
| Single nucleotide polymorphism analysis of the major tripartite multidrug efflux pump of Escherichia coli: functional conservation in disparate animal reservoirs despite exposure to antimicrobial chemotherapy. |
| AID771014 | Induction of DNA intercalation activity of calf thymus DNA topoisomerase 1 assessed as unwinding of pBR322 DNA at 2 ug/ml after 30 mins by Agarose gel electrophoresis | 2013 | European journal of medicinal chemistry, Oct, Volume: 68 | A novel p-terphenyl derivative inducing cell-cycle arrest and apoptosis in MDA-MB-435 cells through topoisomerase inhibition. |
| AID585920 | Antibacterial activity against Streptococcus pneumoniae M308 overexpressing patA, patB and inactivated patB with single mutation by standardized agar doubling dilution method in presence of 20 ug/ml reserpine efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID586087 | Antibacterial activity against dye-resistant Streptococcus pneumoniae M46 DR overexpressing patA, patB by standardized agar doubling dilution method in presence of 20 ug/ml reserpine efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID498878 | Antimicrobial activity against Escherichia coli RAM1129 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1
| Biologic activities of the TolC-like protein of Neisseria meningitidis as assessed by functional complementation in Escherichia coli. |
| AID585713 | Antibacterial activity against Streptococcus pneumoniae M317 overexpressing patA, patB and inactivated patB with single mutation by standardized agar doubling dilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID1632788 | Binding affinity to calf thymus duplex DNA assessed as change in melting temperature at 2.5 uM in pH 7 phosphate buffer by UV-vis spectrophotometric analysis | 2016 | Bioorganic & medicinal chemistry letters, 10-01, Volume: 26, Issue:19
| DNA-binding studies of the natural β-carboline eudistomin U. |
| AID520083 | Antimicrobial activity against aheB-deficient kanamycin-resistant Aeromonas hydrophila subsp. hydrophila ATCC 7966 harboring AheABC efflux pump by agar dilution method in presence of 64 mg/L efflux pump inhibitor phenylalanine-arginine-beta-naphthylamide | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
| Role of the AheABC efflux pump in Aeromonas hydrophila intrinsic multidrug resistance. |
| AID523166 | Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate OC11696 assessed as >= 4 fold increase in bactericidal activity by broth microdilution method in presence of 20 ug/ml reserpine | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| In vitro antibacterial activities of JNJ-Q2, a new broad-spectrum fluoroquinolone. |
| AID498877 | Antimicrobial activity against Escherichia coli RAM4100 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1
| Biologic activities of the TolC-like protein of Neisseria meningitidis as assessed by functional complementation in Escherichia coli. |
| AID520081 | Antimicrobial activity against aheB deficient kanamycin-resistant Aeromonas hydrophila subsp. hydrophila ATCC 7966 harboring plasmid pEX19Gm by agar dilution method in presence of 64 mg/L efflux pump inhibitor phenylalanine-arginine-beta-naphthylamide | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
| Role of the AheABC efflux pump in Aeromonas hydrophila intrinsic multidrug resistance. |
| AID586123 | Antibacterial activity against Streptococcus pneumoniae M319 overexpressing patA, patB and inactivated patB with single mutation by standardized agar doubling dilution method in presence of 50 uM sodium orthovanadate efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID585900 | Antibacterial activity against fluoroquinolone, dye-resistant Streptococcus pneumoniae M296 overexpressing patA, patB by standardized agar doubling dilution method in presence of 20 ug/ml reserpine efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID585496 | Antibacterial activity against dye-resistant Streptococcus pneumoniae by standardized agar doubling dilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID534109 | Ratio of MIC for Pasteurella multocida AL435 to MIC for TolC deficient Pasteurella multocida pm0527 | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11
| Characterization of TolC efflux pump proteins from Pasteurella multocida. |
| AID498876 | Antimicrobial activity against Neisseria meningitidis M7tolC::Kan mtr::Spc by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1
| Biologic activities of the TolC-like protein of Neisseria meningitidis as assessed by functional complementation in Escherichia coli. |
| AID572149 | Activity of Neisseria gonorrhoeae FA19 multidrug efflux protein NorM expressed in Escherichia coli AG100AX assessed as reduction in compound accumulation by fluorimetric assay | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| Functional cloning and characterization of the multidrug efflux pumps NorM from Neisseria gonorrhoeae and YdhE from Escherichia coli. |
| AID1702011 | Binding affinity to calf thymus DNA assessed as binding constant at 298 K by double beam UV-vis spectroscopic analysis | 2018 | Journal of medicinal chemistry, 02-08, Volume: 61, Issue:3
| Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues. |
| AID1810251 | Inhibition of human topoisomerase 1 assessed as DNA intercalation at 1.2 uM using relaxed pHOT-1 DNA as substrate preincubated with DNA for 10 mins followed by enzyme addition and measured after 30 mins by agarose gel electrophoresis | 2021 | Journal of medicinal chemistry, 05-27, Volume: 64, Issue:10
| New Dibenzoquinoxalines Inhibit Triple-Negative Breast Cancer Growth by Dual Targeting of Topoisomerase 1 and the |
| AID368424 | Ratio of MIC for Escherichia coli KAM32 pSTVqepA mutant to MIC for Escherichia coli KAM32 pSTV28 mutant | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9
| New plasmid-mediated fluoroquinolone efflux pump, QepA, found in an Escherichia coli clinical isolate. |
| AID586119 | Antibacterial activity against Streptococcus pneumoniae M316 overexpressing patA, patB and inactivated patA with single mutation by standardized agar doubling dilution method in presence of 50 uM sodium orthovanadate efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID523170 | Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate OC17042 harboring gyrA S84L/G106D, parC S80F and parE D732N mutant gene assessed as >= 4 fold increase in bactericidal activity by broth microdilution method in presence of | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| In vitro antibacterial activities of JNJ-Q2, a new broad-spectrum fluoroquinolone. |
| AID532581 | Antimicrobial activity against Salmonella serovar Typhimurium LT2 by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10
| RamA confers multidrug resistance in Salmonella enterica via increased expression of acrB, which is inhibited by chlorpromazine. |
| AID212909 | Inhibitory activity against telomerase (Compound released from underivatized resin | 2001 | Bioorganic & medicinal chemistry letters, Oct-22, Volume: 11, Issue:20
| Small molecule/nucleic acid affinity chromatography: application for the identification of telomerase inhibitors which target its key RNA/DNA heteroduplex. |
| AID405462 | Antibacterial activity against Escherichia coli TOP10 in presence of 40 ug/ml efflux pump inhibitor 1-(1-naphthylmethyl)-piperazine by Etest | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Transferable resistance to aminoglycosides by methylation of G1405 in 16S rRNA and to hydrophilic fluoroquinolones by QepA-mediated efflux in Escherichia coli. |
| AID572148 | Activity of Escherichia coli K-12 multidrug efflux protein YdhE expressed in Escherichia coli AG100AX assessed as reduction in compound accumulation by fluorimetric assay | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| Functional cloning and characterization of the multidrug efflux pumps NorM from Neisseria gonorrhoeae and YdhE from Escherichia coli. |
| AID396281 | Antibacterial activity against drug-resistant AcrAB-TolC efflux pump deficient Enterobacter cloacae EcdeltaacrA isolate expressing pBGS18 plasmid by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9
| Cloning, nucleotide sequencing, and analysis of the AcrAB-TolC efflux pump of Enterobacter cloacae and determination of its involvement in antibiotic resistance in a clinical isolate. |
| AID1594145 | Inhibition of Escherichia coli GroEL expressed in Escherichia coli DH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed as reduction in GroEL/GroES-mediated denatured rhodanese refolding by measuring rhodanese enzyme activity | 2019 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 29, Issue:9
| HSP60/10 chaperonin systems are inhibited by a variety of approved drugs, natural products, and known bioactive molecules. |
| AID405465 | Antibacterial activity against Escherichia coli TOP10 containing pIP1206 plasmid in presence of 40 ug/ml efflux pump inhibitor 1-(1-naphthylmethyl)-piperazine by Etest | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Transferable resistance to aminoglycosides by methylation of G1405 in 16S rRNA and to hydrophilic fluoroquinolones by QepA-mediated efflux in Escherichia coli. |
| AID31892 | Thermal denaturation in alternating poly(dA-dT)poly(dA-dT) homopolymer (AT) | 1993 | Journal of medicinal chemistry, Jun-11, Volume: 36, Issue:12
| Structure, DNA minor groove binding, and base pair specificity of alkyl- and aryl-linked bis(amidinobenzimidazoles) and bis(amidinoindoles). |
| AID1146806 | Induction of Escherichia coli omega enzyme-mediated relaxation of Escherichia coli (RR1) pBR313 closed circular DNA at 40 X 10'-12 mol preincubated for 10 mins followed by enzyme-addition measured after 30 mins by agarose gel electrophoretic analysis | 1977 | Journal of medicinal chemistry, Aug, Volume: 20, Issue:8
| 2-Deaminoactinomycin D, synthesis and interaction with deoxyribonucleic acid. |
| AID585490 | Antibacterial activity against wild type Streptococcus pneumoniae M4 NCTC 7465 type 1 by standardized agar doubling dilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID54425 | DNA binding property estimated by measuring denaturation temperature on GC to poly (dGC)-poly(dGC), normalized to ethidium bromide | 1992 | Journal of medicinal chemistry, Feb-07, Volume: 35, Issue:3
| Structure and DNA binding activity of analogues of 1,5-bis(4-amidinophenoxy)pentane (pentamidine) |
| AID576014 | Antimicrobial activity against Staphylococcus aureus RDN1 harboring cloned pTZN10 containing cat and bla genes by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10
| Fluoroquinolone efflux by the plasmid-mediated multidrug efflux pump QacB variant QacBIII in Staphylococcus aureus. |
| AID585714 | Antibacterial activity against fluoroquinolone-resistant Streptococcus pneumoniae M83 FQ-R overexpressing patA, patB by standardized agar doubling dilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID585491 | Antibacterial activity against wild type Streptococcus pneumoniae M3 NCTC 7466 type 2 by standardized agar doubling dilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID532765 | Antimicrobial activity against Salmonella serovar Typhimurium SL1344 expressing ramA::aph-pTRC hisA:ramA mutant by broth dilution method in presence of IPTG | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10
| RamA confers multidrug resistance in Salmonella enterica via increased expression of acrB, which is inhibited by chlorpromazine. |
| AID1651229 | Binding affinity at Escherichia coli pBR322 DNA assessed as unwinding of supercoiled DNA incubated for 30 mins in presence of topoisomerase 1 by agarose gel based electrophoresis | 2020 | Bioorganic & medicinal chemistry letters, 02-15, Volume: 30, Issue:4
| Synthesis and biological evaluation of novel indole-pyrazoline hybrid derivatives as potential topoisomerase 1 inhibitors. |
| AID1450867 | Induction of DNA damage in Escherichia coli pBR322 DNA assessed as effect on mobility rate at 5 uM after 1 hr by DNA relaxation assay | 2017 | Journal of medicinal chemistry, 08-24, Volume: 60, Issue:16
| Phthalazino[1,2-b]quinazolinones as p53 Activators: Cell Cycle Arrest, Apoptotic Response and Bak-Bcl-xl Complex Reorganization in Bladder Cancer Cells. |
| AID1287127 | Inhibition of telomerase in human MGC803 cells after 24 hrs by TRAP-PCR-ELISA method | 2016 | Bioorganic & medicinal chemistry letters, Mar-15, Volume: 26, Issue:6
| Identification of human telomerase inhibitors having the core of N-acyl-4,5-dihydropyrazole with anticancer effects. |
| AID586098 | Antibacterial activity against Streptococcus pneumoniae M45A overexpressing patA, patB and inactivated patA with single mutation by standardized agar doubling dilution method in presence of 50 uM sodium orthovanadate efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID1506607 | Induction of DNA intercalation assessed as reduction in topoisomerase 1-mediated DNA relaxation at 100 uM using supercoiled pBR322 DNA incubated for 0.5 hrs in presence of calf thymus topoisomerase 1 by electrophoresis method | 2017 | MedChemComm, Feb-01, Volume: 8, Issue:2
| Novel bivalent securinine mimetics as topoisomerase I inhibitors. |
| AID54427 | DNA binding activity as denaturation temperatures on AT to poly (dA)-poly(dT) normalized to ethidium bromide | 1992 | Journal of medicinal chemistry, Feb-07, Volume: 35, Issue:3
| Structure and DNA binding activity of analogues of 1,5-bis(4-amidinophenoxy)pentane (pentamidine) |
| AID585886 | Antibacterial activity against Streptococcus pneumoniae M45A overexpressing patA, patB and inactivated patA with single mutation by standardized agar doubling dilution method in presence of 20 ug/ml reserpine efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID1502710 | Antimycobacterial activity against Mycobacterium avium isolate MAV1 assessed as reduction in bacterial viability incubated for 3 days by MTT assay | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Natural isoflavone biochanin A as a template for the design of new and potent 3-phenylquinolone efflux inhibitors against Mycobacterium avium. |
| AID532756 | Antimicrobial activity against Salmonella serovar Haifa 9878 by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10
| RamA confers multidrug resistance in Salmonella enterica via increased expression of acrB, which is inhibited by chlorpromazine. |
| AID774947 | Induction of Escherichia coli pBR322 DNA intercalating activity assessed as retardation of DNA at 1 to 2.5 uM after 20 mins by agarose gel electrophoresis | 2013 | European journal of medicinal chemistry, Nov, Volume: 69 | 3-(3-Butylamino-2-hydroxy-propoxy)-1-hydroxy-xanthen-9-one acts as a topoisomerase IIα catalytic inhibitor with low DNA damage. |
| AID406651 | Antibacterial activity against Staphylococcus aureus ACH-0218 isolate with grlA Glu84Lys mutant after 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Dual targeting of DNA gyrase and topoisomerase IV: target interactions of heteroaryl isothiazolones in Staphylococcus aureus. |
| AID585898 | Antibacterial activity against Streptococcus pneumoniae M87A overexpressing patA, patB and inactivated patA with single mutation by standardized agar doubling dilution method in presence of 20 ug/ml reserpine efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID585882 | Antibacterial activity against fluoroquinolone, dye-resistant Streptococcus pneumoniae M42 overexpressing patA, patB by standardized agar doubling dilution method in presence of 20 ug/ml reserpine efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID285532 | Antibacterial activity against ethidium bromide-resistant Staphylococcus aureus BSA643 after 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4
| In vitro and in vivo antibacterial activities of heteroaryl isothiazolones against resistant gram-positive pathogens. |
| AID45400 | Effect on cross resistance of CHO cells resistant to colchicine (CHRC5) | 1990 | Journal of medicinal chemistry, Jul, Volume: 33, Issue:7
| Structure-activity relationships of antineoplastic agents in multidrug resistance. |
| AID585910 | Antibacterial activity against Streptococcus pneumoniae M318 overexpressing patA, patB and inactivated patA with single mutation by standardized agar doubling dilution method in presence of 20 ug/ml reserpine efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID405459 | Antibacterial activity against Escherichia coli C600Rif containing pIP1206 plasmid in presence of 40 ug/ml efflux pump inhibitor 1-(1-naphthylmethyl)-piperazine by Etest | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Transferable resistance to aminoglycosides by methylation of G1405 in 16S rRNA and to hydrophilic fluoroquinolones by QepA-mediated efflux in Escherichia coli. |
| AID405381 | Toxicity against human H9c2 cells assessed as reduction in mitochondrial DNA copy numbers at 0.5 ug/ml after 12 days relative to control | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Absence of a universal mechanism of mitochondrial toxicity by nucleoside analogs. |
| AID1339143 | Binding affinity to synthetic biotin-labeled 30-mer GC-rich duplex DNA in pH 7.8 Tris-Hcl buffer solution assessed as association rate constant in presence of 0.1 M NaCl at 25 degC by QCM sensogram analysis | 2017 | Bioorganic & medicinal chemistry, 02-01, Volume: 25, Issue:3
| Determination of binding modes and binding constants for the complexes of 6H-pyrido[4,3-b]carbazole derivatives with DNA. |
| AID1356631 | Antimicrobial activity against Staphylococcus aureus SA-1199B expressing wild type norA by microdilution method | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| 2-Phenylquinoline S. aureus NorA Efflux Pump Inhibitors: Evaluation of the Importance of Methoxy Group Introduction. |
| AID523167 | Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate OC12501 assessed as >= 4 fold increase in bactericidal activity by broth microdilution method in presence of 20 ug/ml reserpine | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| In vitro antibacterial activities of JNJ-Q2, a new broad-spectrum fluoroquinolone. |
| AID405458 | Antibacterial activity against Escherichia coli C600Rif containing pIP1206 plasmid by Etest | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Transferable resistance to aminoglycosides by methylation of G1405 in 16S rRNA and to hydrophilic fluoroquinolones by QepA-mediated efflux in Escherichia coli. |
| AID532764 | Antimicrobial activity against Salmonella serovar Typhimurium SL1344 expressing ramA::aph-pTRC hisA:ramA mutant by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10
| RamA confers multidrug resistance in Salmonella enterica via increased expression of acrB, which is inhibited by chlorpromazine. |
| AID54452 | Activity against DNA binding in calf thymus was determined | 1987 | Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
| Amplification of bleomycin-mediated degradation of DNA. |
| AID54646 | Intrinsic association constant for DNA | 2004 | Bioorganic & medicinal chemistry letters, Apr-05, Volume: 14, Issue:7
| Synthesis of a novel intercalator based on 2,2'-binaphthalene bearing dimethylammonium groups. |
| AID395135 | Binding affinity to poly(A).poly(U) RNA assessed as change in melting temperature | 2008 | European journal of medicinal chemistry, Nov, Volume: 43, Issue:11
| Ligand binding to nucleic acids and proteins: Does selectivity increase with strength? |
| AID585686 | Antibacterial activity against fluoroquinolone, dye-resistant Streptococcus pneumoniae R6 by standardized agar doubling dilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID582814 | Antibacterial activity against Streptococcus pneumoniae M308 overexpressing patA, patB and inactivated patB with single mutation by standardized agar doubling dilution method in presence of 50 uM sodium orthovanadate efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID233938 | Ratio between poly-dAdT and poly-dGdC binding | 1993 | Journal of medicinal chemistry, Jun-11, Volume: 36, Issue:12
| Structure, DNA minor groove binding, and base pair specificity of alkyl- and aryl-linked bis(amidinobenzimidazoles) and bis(amidinoindoles). |
| AID1339144 | Binding affinity to synthetic biotin-labeled 30-mer GC-rich duplex DNA in pH 7.8 Tris-Hcl buffer solution assessed as dissociation rate constant in presence of 0.1 M NaCl at 25 degC by QCM sensogram analysis | 2017 | Bioorganic & medicinal chemistry, 02-01, Volume: 25, Issue:3
| Determination of binding modes and binding constants for the complexes of 6H-pyrido[4,3-b]carbazole derivatives with DNA. |
| AID585483 | Antibacterial activity against wild type Streptococcus pneumoniae R6 by standardized agar doubling dilution method in presence of 50 uM sodium orthovanadate efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID735444 | Inhibition of telomerase in human SGC7901 cells by TRAP assay | 2013 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 23, Issue:4
| Synthesis, biological evaluation, 3D-QSAR studies of novel aryl-2H-pyrazole derivatives as telomerase inhibitors. |
| AID374687 | Antimicrobial activity against Staphylococcus aureus NCTC 8325-4 expressing NorA gene | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
| The phenolic diterpene totarol inhibits multidrug efflux pump activity in Staphylococcus aureus. |
| AID406809 | Antibacterial activity against Staphylococcus aureus NY2746 isolate with gyrA Ser84Leu and grlA Ser80Phe mutant after 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Dual targeting of DNA gyrase and topoisomerase IV: target interactions of heteroaryl isothiazolones in Staphylococcus aureus. |
| AID406806 | Antibacterial activity against Staphylococcus aureus ACH-0201 isolate with gyrA Ser84Leu, Glu88Val and grlA Ser80Phe, Ala116Val mutant after 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Dual targeting of DNA gyrase and topoisomerase IV: target interactions of heteroaryl isothiazolones in Staphylococcus aureus. |
| AID585885 | Antibacterial activity against fluoroquinolone, dye-resistant Streptococcus pneumoniae M45 overexpressing patA, patB by standardized agar doubling dilution method in presence of 20 ug/ml reserpine efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID538150 | Binding affinity to calf thymus DNA assessed as ratio of final absorbance area to absorbance of compound at 100 uM after 24 hrs by UV spectrophotometer analysis | 2010 | European journal of medicinal chemistry, Nov, Volume: 45, Issue:11
| Structural modifications on the phenazine N,N'-dioxide-scaffold looking for new selective hypoxic cytotoxins. |
| AID584114 | Antibacterial activity against Escherichia coli KAM32 harboring Staphylococcus aureus cloned pSP72 lmrS by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12
| LmrS is a multidrug efflux pump of the major facilitator superfamily from Staphylococcus aureus. |
| AID532582 | Antimicrobial activity against Salmonella serovar Typhimurium 14028S by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10
| RamA confers multidrug resistance in Salmonella enterica via increased expression of acrB, which is inhibited by chlorpromazine. |
| AID585692 | Antibacterial activity against Streptococcus pneumoniae M45B overexpressing patA, patB and inactivated patB with single mutation by standardized agar doubling dilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID1855986 | Binding affinity to DNA (unknown origin) assessed as DNA intercalation at 10 ug/ml by measuring amount of methyl green dye replaced from DNA-methyl green complex | | | |
| AID396280 | Antibacterial activity against drug-resistant AcrAB-TolC efflux pump deficient Enterobacter cloacae EcdeltaacrA isolate by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9
| Cloning, nucleotide sequencing, and analysis of the AcrAB-TolC efflux pump of Enterobacter cloacae and determination of its involvement in antibiotic resistance in a clinical isolate. |
| AID406811 | Antibacterial activity against Staphylococcus aureus BSA643 isolate with gyrA Ser84Leu and grlA Ser80Tyr, Glu84Gly mutant after 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Dual targeting of DNA gyrase and topoisomerase IV: target interactions of heteroaryl isothiazolones in Staphylococcus aureus. |
| AID586128 | Antibacterial activity against Streptococcus pneumoniae M314 overexpressing patA, patB and inactivated patA with single mutation by standardized agar doubling dilution method in presence of 50 uM sodium orthovanadate efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID1339147 | Binding affinity to synthetic biotin-labeled 30-mer GC-rich duplex DNA in pH 7.8 Tris-Hcl buffer solution assessed as ratio of association rate constant to dissociation rate constant in presence of 0.1 M NaCl at 25 degC by QCM sensogram analysis | 2017 | Bioorganic & medicinal chemistry, 02-01, Volume: 25, Issue:3
| Determination of binding modes and binding constants for the complexes of 6H-pyrido[4,3-b]carbazole derivatives with DNA. |
| AID585487 | Antibacterial activity against wild type Streptococcus pneumoniae M3 NCTC 7466 type 2 by standardized agar doubling dilution method in presence of 20 ug/ml reserpine efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID339753 | Binding affinity to synthetic poly(rA):poly(rU) RNA:RNA duplex assessed as melting temperature at 2.2 uM | 2008 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 18, Issue:14
| Molecular recognition of a DNA:RNA hybrid: sub-nanomolar binding by a neomycin-methidium conjugate. |
| AID534107 | Antibacterial activity against TolC deficient Pasteurella multocida pm0527 after 24 hrs by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11
| Characterization of TolC efflux pump proteins from Pasteurella multocida. |
| AID534112 | Ratio of MIC for Pasteurella multocida AL435 to MIC for TolC deficient Pasteurella multocida pm1980 | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11
| Characterization of TolC efflux pump proteins from Pasteurella multocida. |
| AID532754 | Antimicrobial activity against Salmonella serovar Hadar by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10
| RamA confers multidrug resistance in Salmonella enterica via increased expression of acrB, which is inhibited by chlorpromazine. |
| AID585730 | Antibacterial activity against Streptococcus pneumoniae M46A overexpressing patA, patB and inactivated patA with single mutation by standardized agar doubling dilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID368915 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus effluxing isolate | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9
| Efflux-related resistance to norfloxacin, dyes, and biocides in bloodstream isolates of Staphylococcus aureus. |
| AID576018 | Antimicrobial activity against Staphylococcus aureus RDN1 harboring cloned pTZ2162-encoded QacBIII E320A mutant gene by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10
| Fluoroquinolone efflux by the plasmid-mediated multidrug efflux pump QacB variant QacBIII in Staphylococcus aureus. |
| AID510750 | Antibacterial activity against Escherichia coli AG102MB harboring pS1328-based acrB gene | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
| Single nucleotide polymorphism analysis of the major tripartite multidrug efflux pump of Escherichia coli: functional conservation in disparate animal reservoirs despite exposure to antimicrobial chemotherapy. |
| AID585890 | Antibacterial activity against Streptococcus pneumoniae M50B overexpressing patA, patB and inactivated patB with single mutation by standardized agar doubling dilution method in presence of 20 ug/ml reserpine efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID396042 | Antibacterial activity against drug-resistant Enterobacter cloacae EcDC64 isolate expressing AcrAB-TolC efflux pump by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9
| Cloning, nucleotide sequencing, and analysis of the AcrAB-TolC efflux pump of Enterobacter cloacae and determination of its involvement in antibiotic resistance in a clinical isolate. |
| AID406654 | Antibacterial activity against Staphylococcus aureus ACH-0186 isolate with gyrA Ser84Leu and grlA Ser80Phe, Ala116Val mutant after 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Dual targeting of DNA gyrase and topoisomerase IV: target interactions of heteroaryl isothiazolones in Staphylococcus aureus. |
| AID1502706 | Antimycobacterial activity against Mycobacterium avium 104 assessed as reduction in bacterial viability incubated for 3 days by MTT assay | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Natural isoflavone biochanin A as a template for the design of new and potent 3-phenylquinolone efflux inhibitors against Mycobacterium avium. |
| AID1594144 | Inhibition of Escherichia coli GroEL expressed in Escherichia coliDH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed as reduction in GroEL/GroES-mediated denatured soluble pig heart MDH refolding by measuring MDH enzyme acti | 2019 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 29, Issue:9
| HSP60/10 chaperonin systems are inhibited by a variety of approved drugs, natural products, and known bioactive molecules. |
| AID586127 | Antibacterial activity against fluoroquinolone-resistant Streptococcus pneumoniae M98 FQ-R overexpressing patA, patB by standardized agar doubling dilution method in presence of 50 uM sodium orthovanadate efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID283558 | Antibacterial activity against Escherichia coli AG102 with marR1 mutation after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Mar, Volume: 51, Issue:3
| Substrate competition studies using whole-cell accumulation assays with the major tripartite multidrug efflux pumps of Escherichia coli. |
| AID615635 | Displacement of methyl green dye from DNA after 24 hrs by spectrophotometric analysis | 2011 | European journal of medicinal chemistry, Sep, Volume: 46, Issue:9
| Synthesis and antitumor activity of new sulfonamide derivatives of thiadiazolo[3,2-a]pyrimidines. |
| AID585897 | Antibacterial activity against fluoroquinolone, dye-resistant Streptococcus pneumoniae M87 overexpressing patA, patB by standardized agar doubling dilution method in presence of 20 ug/ml reserpine efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID339754 | Binding affinity to synthetic poly(dA):poly(rU) DNA:RNA hybrid assessed as melting temperature at 2.2 uM | 2008 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 18, Issue:14
| Molecular recognition of a DNA:RNA hybrid: sub-nanomolar binding by a neomycin-methidium conjugate. |
| AID405377 | Toxicity against human H9c2 cells assessed as increase in mitochondrial superoxide production at 0.5 ug/ml after 4 to 14 days by flow cytometry | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Absence of a universal mechanism of mitochondrial toxicity by nucleoside analogs. |
| AID586092 | Antibacterial activity against Streptococcus pneumoniae M309 overexpressing patA, patB and inactivated patB with single mutation by standardized agar doubling dilution method in presence of 20 ug/ml reserpine efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID585720 | Antibacterial activity against fluoroquinolone-resistant Streptococcus pneumoniae M98 FQ-R overexpressing patA, patB by standardized agar doubling dilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID582823 | Antibacterial activity against Streptococcus pneumoniae M309 overexpressing patA, patB and inactivated patB with single mutation by standardized agar doubling dilution method in presence of 50 uM sodium orthovanadate efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID585891 | Antibacterial activity against fluoroquinolone, dye-resistant Streptococcus pneumoniae M74 overexpressing patA, patB by standardized agar doubling dilution method in presence of 20 ug/ml reserpine efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID498875 | Antimicrobial activity against Neisseria meningitidis M7mtrE::Spc by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1
| Biologic activities of the TolC-like protein of Neisseria meningitidis as assessed by functional complementation in Escherichia coli. |
| AID53470 | Inhibitory dose against oncornaviral DNA polymerase activity of moloney murine leukemia virus | 1980 | Journal of medicinal chemistry, Jul, Volume: 23, Issue:7
| Diaryl amidine derivatives as oncornaviral DNA polymerase inhibitors. |
| AID586109 | Antibacterial activity against fluoroquinolone, dye-resistant Streptococcus pneumoniae M87 overexpressing patA, patB by standardized agar doubling dilution method in presence of 50 uM sodium orthovanadate efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID405367 | Toxicity against human sHepG2/C3A cells assessed as reduction in mitochondrial DNA copy numbers at 0.5 ug/ml after 6 days relative to control | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Absence of a universal mechanism of mitochondrial toxicity by nucleoside analogs. |
| AID487000 | Binding affinity to calf thymus DNA assessed as ratio of final absorbance area to the absorbance at 100 uM after 24 hrs by UV spectrophotometer analysis relative to control | 2010 | Bioorganic & medicinal chemistry, Jun-15, Volume: 18, Issue:12
| Study of benzo[a]phenazine 7,12-dioxide as selective hypoxic cytotoxin-scaffold. Identification of aerobic-antitumoral activity through DNA fragmentation. |
| AID977599 | Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM | 2013 | Molecular pharmacology, Jun, Volume: 83, Issue:6
| Structure-based identification of OATP1B1/3 inhibitors. |
| AID405468 | Antibacterial activity against Escherichia coli TOP10 containing pAT851 in presence of 40 ug/ml efflux pump inhibitor 1-(1-naphthylmethyl)-piperazine by Etest | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Transferable resistance to aminoglycosides by methylation of G1405 in 16S rRNA and to hydrophilic fluoroquinolones by QepA-mediated efflux in Escherichia coli. |
| AID368419 | Antimicrobial activity against Escherichia coli KAM32 expressing deltaacrB ydhE hsd gene by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9
| New plasmid-mediated fluoroquinolone efflux pump, QepA, found in an Escherichia coli clinical isolate. |
| AID585895 | Antibacterial activity against Streptococcus pneumoniae M86A overexpressing patA, patB and inactivated patA with single mutation by standardized agar doubling dilution method in presence of 20 ug/ml reserpine efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID23271 | Partition coefficient (logD7.4) | 1990 | Journal of medicinal chemistry, Jul, Volume: 33, Issue:7
| Structure-activity relationships of antineoplastic agents in multidrug resistance. |
| AID586124 | Antibacterial activity against fluoroquinolone-resistant Streptococcus pneumoniae M97 FQ-R overexpressing patA, patB by standardized agar doubling dilution method in presence of 50 uM sodium orthovanadate efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID585682 | Antibacterial activity against dye-resistant Streptococcus pneumoniae by standardized agar doubling dilution method in presence of 50 uM sodium orthovanadate efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID537601 | Inhibition of telomerase in human SGC7901 cells by TRAP assay | 2010 | Bioorganic & medicinal chemistry, Nov-15, Volume: 18, Issue:22
| Synthesis, biological evaluation, and molecular docking studies of 2-chloropyridine derivatives possessing 1,3,4-oxadiazole moiety as potential antitumor agents. |
| AID585693 | Antibacterial activity against fluoroquinolone, dye-resistant Streptococcus pneumoniae M50 overexpressing patA, patB by standardized agar doubling dilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID586110 | Antibacterial activity against Streptococcus pneumoniae M87A overexpressing patA, patB and inactivated patA with single mutation by standardized agar doubling dilution method in presence of 50 uM sodium orthovanadate efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID695925 | Inhibition of HIV-1 reverse transcriptase using Poly(rA).p(dT) (12 to 18) as substrate after 30 mins by single point PCR assay | 2012 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14
| Inhibition of therapeutically important polymerases with high affinity bis-intercalators. |
| AID520088 | Antimicrobial activity against Aeromonas hydrophila subsp. hydrophila ATCC 7966 harboring plasmid pEX19Gm by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
| Role of the AheABC efflux pump in Aeromonas hydrophila intrinsic multidrug resistance. |
| AID405457 | Antibacterial activity against Escherichia coli C600Rif in presence of 50 ug/ml efflux pump inhibitor phenyl-arginine-beta-naphthylamide by Etest | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Transferable resistance to aminoglycosides by methylation of G1405 in 16S rRNA and to hydrophilic fluoroquinolones by QepA-mediated efflux in Escherichia coli. |
| AID54423 | Denaturation temperature change on binding to AT to poly (dA)-poly(dT) | 1992 | Journal of medicinal chemistry, Feb-07, Volume: 35, Issue:3
| Structure and DNA binding activity of analogues of 1,5-bis(4-amidinophenoxy)pentane (pentamidine) |
| AID1356635 | Antimicrobial activity against mepA overexpressing Staphylococcus aureus SA-K2886 by microdilution method | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| 2-Phenylquinoline S. aureus NorA Efflux Pump Inhibitors: Evaluation of the Importance of Methoxy Group Introduction. |
| AID585880 | Antibacterial activity against Streptococcus pneumoniae M309 overexpressing patA, patB and inactivated patB with single mutation by standardized agar doubling dilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID586093 | Antibacterial activity against fluoroquinolone, dye-resistant Streptococcus pneumoniae R6 by standardized agar doubling dilution method in presence of 50 uM sodium orthovanadate efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID357846 | Binding affinity to yeast tRNA assessed as reduction in tRNA peak by pre-incubation method | | | |
| AID584118 | Inhibition of Staphylococcus aureus LmrS expressed in Escherichia coli KAM32 harboring pSP72 assessed as decrease of ethidium bromide accumulation at 100 uM by fluorescence spectrophotometer relative to control | 2010 | Antimicrobial agents and chemotherapy, Dec, Volume: 54, Issue:12
| LmrS is a multidrug efflux pump of the major facilitator superfamily from Staphylococcus aureus. |
| AID248001 | Concentration required to inhibit 50% of human carcinoma SKOV3 cell lines | 2004 | Bioorganic & medicinal chemistry letters, Dec-06, Volume: 14, Issue:23
| Evaluation of by disubstituted acridone derivatives as telomerase inhibitors: the importance of G-quadruplex binding. |
| AID405378 | Toxicity against human HepG2/C3A cells assessed as reduction in mitochondrial DNA copy numbers at 0.5 ug/ml after 4 days relative to control | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Absence of a universal mechanism of mitochondrial toxicity by nucleoside analogs. |
| AID585687 | Antibacterial activity against fluoroquinolone, dye-resistant Streptococcus pneumoniae M42 overexpressing patA, patB by standardized agar doubling dilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID585704 | Antibacterial activity against Streptococcus pneumoniae M87B overexpressing patA, patB and inactivated patB with single mutation by standardized agar doubling dilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID532760 | Antimicrobial activity against Salmonella serovar Newport 129 by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10
| RamA confers multidrug resistance in Salmonella enterica via increased expression of acrB, which is inhibited by chlorpromazine. |
| AID572157 | Binding affinity to Neisseria gonorrhoeae FA19 multidrug efflux protein NorM expressed in Escherichia coli AG100AX in presence of 0.02% DDM surfactant by fluorescence polarization assay | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| Functional cloning and characterization of the multidrug efflux pumps NorM from Neisseria gonorrhoeae and YdhE from Escherichia coli. |
| AID472812 | Cytotoxicity against human HBI10A cells | 2010 | Bioorganic & medicinal chemistry, Apr-15, Volume: 18, Issue:8
| Allosteric inhibitors of hepatitis C virus NS5B polymerase thumb domain site II: structure-based design and synthesis of new templates. |
| AID585733 | Antibacterial activity against Streptococcus pneumoniae M303 overexpressing patA, patB and inactivated patA with single mutation by standardized agar doubling dilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID405469 | Antibacterial activity against Escherichia coli TOP10 containing pAT851 in presence of 50 ug/ml efflux pump inhibitor phenyl-arginine-beta-naphthylamide by Etest | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Transferable resistance to aminoglycosides by methylation of G1405 in 16S rRNA and to hydrophilic fluoroquinolones by QepA-mediated efflux in Escherichia coli. |
| AID585718 | Antibacterial activity against Streptococcus pneumoniae M302 overexpressing patA, patB and inactivated patA with single mutation by standardized agar doubling dilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID285531 | Antibacterial activity against ethidium bromide-resistant Staphylococcus aureus Mu50 in presence of 20 ug/ml reserpine after 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4
| In vitro and in vivo antibacterial activities of heteroaryl isothiazolones against resistant gram-positive pathogens. |
| AID585699 | Antibacterial activity against fluoroquinolone, dye-resistant Streptococcus pneumoniae M86 overexpressing patA, patB by standardized agar doubling dilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID585917 | Antibacterial activity against Streptococcus pneumoniae M307 overexpressing patA, patB and inactivated patB with single mutation by standardized agar doubling dilution method in presence of 20 ug/ml reserpine efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID1356626 | Cytotoxicity in human HepG2 cells assessed as reduction in cell viability incubated for 24 hrs by ATP bioluminescence assay | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| 2-Phenylquinoline S. aureus NorA Efflux Pump Inhibitors: Evaluation of the Importance of Methoxy Group Introduction. |
| AID523168 | Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate OC8530 harboring gyrA S84L and parC I143V mutant gene assessed as >= 4 fold increase in bactericidal activity by broth microdilution method in presence of 20 ug/ml reserpin | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| In vitro antibacterial activities of JNJ-Q2, a new broad-spectrum fluoroquinolone. |
| AID532766 | Antimicrobial activity against Salmonella serovar Typhimurium SL1344 expressing ramA::aph-pTRC hisA:ramA mutant by broth dilution method in presence of chlorpromzine | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10
| RamA confers multidrug resistance in Salmonella enterica via increased expression of acrB, which is inhibited by chlorpromazine. |
| AID576023 | Antimicrobial activity against Staphylococcus aureus RDN1 harboring cloned pTZ2238-encoded QacBIV E377G mutant gene by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10
| Fluoroquinolone efflux by the plasmid-mediated multidrug efflux pump QacB variant QacBIII in Staphylococcus aureus. |
| AID585906 | Antibacterial activity against fluoroquinolone-resistant Streptococcus pneumoniae M79 FQ-R overexpressing patA, patB by standardized agar doubling dilution method in presence of 20 ug/ml reserpine efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID374688 | Antimicrobial activity against NorA deficient Staphylococcus aureus K1758 | 2007 | Antimicrobial agents and chemotherapy, Dec, Volume: 51, Issue:12
| The phenolic diterpene totarol inhibits multidrug efflux pump activity in Staphylococcus aureus. |
| AID585894 | Antibacterial activity against fluoroquinolone, dye-resistant Streptococcus pneumoniae M86 overexpressing patA, patB by standardized agar doubling dilution method in presence of 20 ug/ml reserpine efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID498880 | Antimicrobial activity against Escherichia cloi RAM1129 transfected with pNK1 containg Neisseria meningitidis tolC gene by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1
| Biologic activities of the TolC-like protein of Neisseria meningitidis as assessed by functional complementation in Escherichia coli. |
| AID639393 | Binding affinity to calf thymus DNA assessed as binding constant at pH 7 by fluorescence quenching assay | 2011 | Bioorganic & medicinal chemistry, Nov-01, Volume: 19, Issue:21
| Novel biologically active nitro and amino substituted benzimidazo[1,2-a]quinolines. |
| AID585489 | Antibacterial activity against wild type Streptococcus pneumoniae R6 by standardized agar doubling dilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID1594134 | Inhibition of native soluble pig heart MDH assessed as reduction in MDH enzyme activity using sodium mesoxalate as substrate and NADH by malachite green dye based spectrometric analysis | 2019 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 29, Issue:9
| HSP60/10 chaperonin systems are inhibited by a variety of approved drugs, natural products, and known bioactive molecules. |
| AID405380 | Toxicity against human HepG2/C3A cells assessed as reduction in mitochondrial DNA copy numbers at 0.5 ug/ml after 14 days relative to control | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Absence of a universal mechanism of mitochondrial toxicity by nucleoside analogs. |
| AID368918 | Inhibition of multidrug-resistant efflux pump in methicillin-resistant Staphylococcus aureus effluxing isolate assessed as fold reduction of ethidium-bromide MIC at 10 ug/ml by microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9
| Efflux-related resistance to norfloxacin, dyes, and biocides in bloodstream isolates of Staphylococcus aureus. |
| AID405463 | Antibacterial activity against Escherichia coli TOP10 in presence of 50 ug/ml efflux pump inhibitor phenyl-arginine-beta-naphthylamide by Etest | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Transferable resistance to aminoglycosides by methylation of G1405 in 16S rRNA and to hydrophilic fluoroquinolones by QepA-mediated efflux in Escherichia coli. |
| AID357845 | Binding affinity to calf thymus DNA assessed as reduction in DNA peak by pre-incubation method | | | |
| AID534108 | Antibacterial activity against Pasteurella multocida pm0527 after 24 hrs by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11
| Characterization of TolC efflux pump proteins from Pasteurella multocida. |
| AID586091 | Antibacterial activity against Streptococcus pneumoniae M303 overexpressing patA, patB and inactivated patA with single mutation by standardized agar doubling dilution method in presence of 20 ug/ml reserpine efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID1352098 | Induction of Escherichia coli pBR322 DNA intercalation assessed as transformation of topoisomerase1-relaxed pBR322 DNA in to supercoiled DNA preincubated for 10 mins followed by topoisomerase-1 addition measured after 30 mins by agarose gel electrophoresi | 2018 | European journal of medicinal chemistry, Feb-10, Volume: 145 | Synthesis of carbazole derivatives containing chalcone analogs as non-intercalative topoisomerase II catalytic inhibitors and apoptosis inducers. |
| AID585709 | Antibacterial activity against Streptococcus pneumoniae M311 overexpressing patA, patB and inactivated patA with single mutation by standardized agar doubling dilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID396283 | Antibacterial activity against drug-resistant AcrAB-TolC efflux pump deficient Enterobacter cloacae EcdeltaacrA isolate expressing pACYC184 plasmid by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9
| Cloning, nucleotide sequencing, and analysis of the AcrAB-TolC efflux pump of Enterobacter cloacae and determination of its involvement in antibiotic resistance in a clinical isolate. |
| AID585488 | Antibacterial activity against wild type Streptococcus pneumoniae M4 NCTC 7465 type 1 by standardized agar doubling dilution method in presence of 20 ug/ml reserpine efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID582820 | Antibacterial activity against Streptococcus pneumoniae M46B overexpressing patA, patB and inactivated patB with single mutation by standardized agar doubling dilution method in presence of 50 uM sodium orthovanadate efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID582816 | Antibacterial activity against Streptococcus pneumoniae M300 overexpressing patA, patB and inactivated patA with single mutation by standardized agar doubling dilution method in presence of 50 uM sodium orthovanadate efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID585717 | Antibacterial activity against fluoroquinolone-resistant Streptococcus pneumoniae M97 FQ-R overexpressing patA, patB by standardized agar doubling dilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID472814 | Selectivity index, ratio of CC50 for human HBI10A cells to EC50 for Hepatitis C virus | 2010 | Bioorganic & medicinal chemistry, Apr-15, Volume: 18, Issue:8
| Allosteric inhibitors of hepatitis C virus NS5B polymerase thumb domain site II: structure-based design and synthesis of new templates. |
| AID585721 | Antibacterial activity against Streptococcus pneumoniae M314 overexpressing patA, patB and inactivated patA with single mutation by standardized agar doubling dilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID585690 | Antibacterial activity against fluoroquinolone, dye-resistant Streptococcus pneumoniae M45 overexpressing patA, patB by standardized agar doubling dilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID405376 | Toxicity against human HepG2/C3A cells assessed as increase in mitochondrial superoxide production at 0.5 ug/ml after 4 to 14 days by flow cytometry | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Absence of a universal mechanism of mitochondrial toxicity by nucleoside analogs. |
| AID586094 | Antibacterial activity against fluoroquinolone, dye-resistant Streptococcus pneumoniae M42 overexpressing patA, patB by standardized agar doubling dilution method in presence of 50 uM sodium orthovanadate efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID368420 | Antimicrobial activity against Escherichia coli KAM32 pHPA containing mutated GyrA gene by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9
| New plasmid-mediated fluoroquinolone efflux pump, QepA, found in an Escherichia coli clinical isolate. |
| AID585889 | Antibacterial activity against Streptococcus pneumoniae M50A overexpressing patA, patB and inactivated patA with single mutation by standardized agar doubling dilution method in presence of 20 ug/ml reserpine efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID54424 | Denaturation temperature change on binding on GC to poly(dGC)-poly(dGC) | 1992 | Journal of medicinal chemistry, Feb-07, Volume: 35, Issue:3
| Structure and DNA binding activity of analogues of 1,5-bis(4-amidinophenoxy)pentane (pentamidine) |
| AID585923 | Antibacterial activity against Streptococcus pneumoniae M55B overexpressing patA, patB and inactivated patB with single mutation by standardized agar doubling dilution method in presence of 20 ug/ml reserpine efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID534111 | Antibacterial activity against Pasteurella multocida pm1980 after 24 hrs by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11
| Characterization of TolC efflux pump proteins from Pasteurella multocida. |
| AID405372 | Toxicity against human HepG2/C3A cells assessed as inhibition of cell proliferation at 0.5 ug/ml after 6 days by SRB assay | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Absence of a universal mechanism of mitochondrial toxicity by nucleoside analogs. |
| AID585896 | Antibacterial activity against Streptococcus pneumoniae M86B overexpressing patA, patB and inactivated patB with single mutation by standardized agar doubling dilution method in presence of 20 ug/ml reserpine efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID585922 | Antibacterial activity against Streptococcus pneumoniae M300 overexpressing patA, patB and inactivated patA with single mutation by standardized agar doubling dilution method in presence of 20 ug/ml reserpine efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID1502712 | Antimycobacterial activity against Mycobacterium avium isolate MAV3 assessed as reduction in bacterial viability incubated for 3 days by MTT assay | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Natural isoflavone biochanin A as a template for the design of new and potent 3-phenylquinolone efflux inhibitors against Mycobacterium avium. |
| AID368418 | Antimicrobial activity against multidrug-resistant Escherichia coli C316 pHPA containing mutated GyrA gene by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9
| New plasmid-mediated fluoroquinolone efflux pump, QepA, found in an Escherichia coli clinical isolate. |
| AID1891166 | Inhibition of topoisomerase 1 (unknown origin) assessed as DNA intercalation at 1 mM using pBR322 DNA as substrate measured after 30 mins by gel electrophoresis relative to control | 2022 | Bioorganic & medicinal chemistry, 05-01, Volume: 61 | Discovery, Topo I inhibitory activity and mechanism evaluation of two novel cytisine-type alkaloid dimers from the seeds of Sophora alopecuroides L. |
| AID406650 | Antibacterial activity against Staphylococcus aureus ACH-0216 isolate with grlA Ser80Phe mutant after 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Dual targeting of DNA gyrase and topoisomerase IV: target interactions of heteroaryl isothiazolones in Staphylococcus aureus. |
| AID498879 | Antimicrobial activity against Escherichia cloi RAM1129 transfected with pGCC4 containg IPTG-inducible lacZ promoter by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1
| Biologic activities of the TolC-like protein of Neisseria meningitidis as assessed by functional complementation in Escherichia coli. |
| AID1374954 | Inhibition of human topoisomerase-2 assessed as DNA intercalation by measuring relaxation of supercoiled pBR322 plasmid DNA at 0.3 to 2.5 uM after 6 mins by agarose gel electrophoresis | 2018 | Bioorganic & medicinal chemistry letters, 05-01, Volume: 28, Issue:8
| Synthesis and biological evaluation of novel carbazole-rhodanine conjugates as topoisomerase II inhibitors. |
| AID1204358 | Inhibition of telomerase in human MDA-MB-231 cells after 24 hrs by TRAP-PCR-ELISA | 2015 | European journal of medicinal chemistry, Jun-05, Volume: 97 | Novel myricetin derivatives: Design, synthesis and anticancer activity. |
| AID405466 | Antibacterial activity against Escherichia coli TOP10 containing pIP1206 plasmid in presence of 50 ug/ml efflux pump inhibitor phenyl-arginine-beta-naphthylamide by Etest | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Transferable resistance to aminoglycosides by methylation of G1405 in 16S rRNA and to hydrophilic fluoroquinolones by QepA-mediated efflux in Escherichia coli. |
| AID586100 | Antibacterial activity against fluoroquinolone, dye-resistant Streptococcus pneumoniae M50 overexpressing patA, patB by standardized agar doubling dilution method in presence of 50 uM sodium orthovanadate efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID572151 | Antimicrobial activity against AcrAB-deficient Escherichia coli AG100AX harboring pBADomegaydhE plasmid containing Escherichia coli multidrug efflux pump YdhE after 18 to 24 hrs by two fold dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| Functional cloning and characterization of the multidrug efflux pumps NorM from Neisseria gonorrhoeae and YdhE from Escherichia coli. |
| AID586105 | Antibacterial activity against Streptococcus pneumoniae M305 overexpressing patA, patB and inactivated patB with single mutation by standardized agar doubling dilution method in presence of 50 uM sodium orthovanadate efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID585883 | Antibacterial activity against Streptococcus pneumoniae M298 overexpressing patA, patB and inactivated patA with single mutation by standardized agar doubling dilution method in presence of 20 ug/ml reserpine efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID1379617 | Binding affinity to calf thymus DNA assessed as increase in relative viscosity of DNA-compound complex at 5 uM by viscometry | 2017 | European journal of medicinal chemistry, Nov-10, Volume: 140 | Synthesis of substituted phenanthrene-9-benzimidazole conjugates: Cytotoxicity evaluation and apoptosis inducing studies. |
| AID585732 | Antibacterial activity against fluoroquinolone, dye-susceptible Streptococcus pneumoniae M295 S overexpressing patA, patB by standardized agar doubling dilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID54426 | Denaturation temperature change on binding to calf thymus DNA | 1992 | Journal of medicinal chemistry, Feb-07, Volume: 35, Issue:3
| Structure and DNA binding activity of analogues of 1,5-bis(4-amidinophenoxy)pentane (pentamidine) |
| AID586117 | Antibacterial activity against Streptococcus pneumoniae M311B overexpressing patA, patB and inactivated patB with single mutation by standardized agar doubling dilution method in presence of 50 uM sodium orthovanadate efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID594636 | Inhibition of telomerase activity expressed in human SGC7901 cells by SYBER green dye based TRAP | 2011 | Bioorganic & medicinal chemistry letters, May-15, Volume: 21, Issue:10
| Design and synthesis of N-phenylacetyl (sulfonyl) 4,5-dihydropyrazole derivatives as potential antitumor agents. |
| AID405464 | Antibacterial activity against Escherichia coli TOP10 containing pIP1206 plasmid by Etest | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Transferable resistance to aminoglycosides by methylation of G1405 in 16S rRNA and to hydrophilic fluoroquinolones by QepA-mediated efflux in Escherichia coli. |
| AID586125 | Antibacterial activity against Streptococcus pneumoniae M302 overexpressing patA, patB and inactivated patA with single mutation by standardized agar doubling dilution method in presence of 50 uM sodium orthovanadate efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID582817 | Antibacterial activity against Streptococcus pneumoniae M55B overexpressing patA, patB and inactivated patB with single mutation by standardized agar doubling dilution method in presence of 50 uM sodium orthovanadate efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID523169 | Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate OC4222 harboring gyrA S84L and parC S80F mutant gene assessed as >= 4 fold increase in bactericidal activity by broth microdilution method in presence of 20 ug/ml reserpine | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| In vitro antibacterial activities of JNJ-Q2, a new broad-spectrum fluoroquinolone. |
| AID512633 | Binding affinity to human c-MYC Pu24I G-quadruplex structure assessed as stabilization of G-quadruplex by NMR spectroscopy | 2005 | Nature chemical biology, Aug, Volume: 1, Issue:3
| Small-molecule interaction with a five-guanine-tract G-quadruplex structure from the human MYC promoter. |
| AID585722 | Antibacterial activity against Streptococcus pneumoniae M307 overexpressing patA, patB and inactivated patB with single mutation by standardized agar doubling dilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID585694 | Antibacterial activity against Streptococcus pneumoniae M50A overexpressing patA, patB and inactivated patA with single mutation by standardized agar doubling dilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID406807 | Antibacterial activity against Staphylococcus aureus ACH-0141 isolate with gyrA Ser84Leu, Glu88Val and grlA Ser80Phe, Ala116Val mutant after 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Dual targeting of DNA gyrase and topoisomerase IV: target interactions of heteroaryl isothiazolones in Staphylococcus aureus. |
| AID405461 | Antibacterial activity against Escherichia coli TOP10 by Etest | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Transferable resistance to aminoglycosides by methylation of G1405 in 16S rRNA and to hydrophilic fluoroquinolones by QepA-mediated efflux in Escherichia coli. |
| AID1632804 | Binding affinity to calf thymus duplex DNA assessed as melting temperature at 0.5 mM by differential scanning calorimetry (Rvb = 51 degC) | 2016 | Bioorganic & medicinal chemistry letters, 10-01, Volume: 26, Issue:19
| DNA-binding studies of the natural β-carboline eudistomin U. |
| AID660264 | Ratio of MIC for wild type Escherichia coli HS414 to MIC for acrB-deficient Escherichia coli HS832 by agar dilution method | 2012 | European journal of medicinal chemistry, Jun, Volume: 52 | Computational analysis of structure-based interactions and ligand properties can predict efflux effects on antibiotics. |
| AID586121 | Antibacterial activity against fluoroquinolone-resistant Streptococcus pneumoniae M83 FQ-R overexpressing patA, patB by standardized agar doubling dilution method in presence of 50 uM sodium orthovanadate efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID534110 | Antibacterial activity against TolC deficient Pasteurella multocida pm1980 after 24 hrs by broth dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11
| Characterization of TolC efflux pump proteins from Pasteurella multocida. |
| AID586101 | Antibacterial activity against Streptococcus pneumoniae M50A overexpressing patA, patB and inactivated patA with single mutation by standardized agar doubling dilution method in presence of 50 uM sodium orthovanadate efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID586089 | Antibacterial activity against Streptococcus pneumoniae M46B overexpressing patA, patB and inactivated patB with single mutation by standardized agar doubling dilution method in presence of 20 ug/ml reserpine efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID585700 | Antibacterial activity against Streptococcus pneumoniae M86A overexpressing patA, patB and inactivated patA with single mutation by standardized agar doubling dilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID498873 | Antimicrobial activity against Neisseria meningitidis M7 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jan, Volume: 54, Issue:1
| Biologic activities of the TolC-like protein of Neisseria meningitidis as assessed by functional complementation in Escherichia coli. |
| AID585909 | Antibacterial activity against fluoroquinolone-resistant Streptococcus pneumoniae M83 FQ-R overexpressing patA, patB by standardized agar doubling dilution method in presence of 20 ug/ml reserpine efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID247965 | Concentration required to inhibit 50% of human carcinoma CH1 cell lines | 2004 | Bioorganic & medicinal chemistry letters, Dec-06, Volume: 14, Issue:23
| Evaluation of by disubstituted acridone derivatives as telomerase inhibitors: the importance of G-quadruplex binding. |
| AID585719 | Antibacterial activity against Streptococcus pneumoniae M306 overexpressing patA, patB and inactivated patB with single mutation by standardized agar doubling dilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID1537210 | Binding affinity to calf thymus DNA assessed as DNA intercalation by measuring increase in viscosity at 5 uM by Ostwald viscometric method | 2019 | Bioorganic & medicinal chemistry, 03-01, Volume: 27, Issue:5
| Synthesis and biological evaluation of pyrazole linked benzothiazole-β-naphthol derivatives as topoisomerase I inhibitors with DNA binding ability. |
| AID368423 | Antimicrobial activity against Escherichia coli KAM32 pSTVdeltaqepA containing disrupted qepA gene by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9
| New plasmid-mediated fluoroquinolone efflux pump, QepA, found in an Escherichia coli clinical isolate. |
| AID585903 | Antibacterial activity against fluoroquinolone, dye-resistant Streptococcus pneumoniae M297 overexpressing patA, patB by standardized agar doubling dilution method in presence of 20 ug/ml reserpine efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID753092 | Binding affinity to calf thymus DNA after 1.5 hrs by spectroscopic titration | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | Synthesis, cytotoxic activity and DNA-interaction studies of novel anthraquinone-thiosemicarbazones with tautomerizable methylene group. |
| AID572150 | Antimicrobial activity against AcrAB-deficient Escherichia coli AG100AX harboring pBAD plasmid after 18 to 24 hrs by two fold dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| Functional cloning and characterization of the multidrug efflux pumps NorM from Neisseria gonorrhoeae and YdhE from Escherichia coli. |
| AID368422 | Antimicrobial activity against Escherichia coli KAM32 pSTVqepA containing qepA gene ligated to pSTV28 plasmid by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9
| New plasmid-mediated fluoroquinolone efflux pump, QepA, found in an Escherichia coli clinical isolate. |
| AID586090 | Antibacterial activity against fluoroquinolone, dye-susceptible Streptococcus pneumoniae M295 S overexpressing patA, patB by standardized agar doubling dilution method in presence of 20 ug/ml reserpine efflux pump inhibitor | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID653484 | Inhibition of telomerase supercoiling activity in human MGC803 cells after 24 hrs by TRAP-PCR-ELISA assay | 2012 | European journal of medicinal chemistry, May, Volume: 51 | Design and synthesis of novel 5-phenyl-N-piperidine ethanone containing 4,5-dihydropyrazole derivatives as potential antitumor agents. |
| AID406813 | Antibacterial activity against Staphylococcus aureus ACH-0231 isolate with gyrA Ser84Leu, Glu88Lys and grlA Ser80Tyr, Glu84Gly mutant after 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Dual targeting of DNA gyrase and topoisomerase IV: target interactions of heteroaryl isothiazolones in Staphylococcus aureus. |
| AID405370 | Toxicity in human HepG2/C3A cells assessed as cell viability at 0.5 ug/ml after 14 days | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Absence of a universal mechanism of mitochondrial toxicity by nucleoside analogs. |
| AID585726 | Antibacterial activity against dye-resistant Streptococcus pneumoniae M55 DR overexpressing patA, patB by standardized agar doubling dilution method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Overexpression of patA and patB, which encode ABC transporters, is associated with fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae. |
| AID743748 | Displacement of methyl green from DNA (unknown origin) after 24 hrs | 2013 | European journal of medicinal chemistry, May, Volume: 63 | Synthesis, in vitro antitumor evaluation and DNA-binding study of novel tetrahydroquinolines and some derived tricyclic and tetracyclic ring systems. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID720501 | qHTS for Inhibitors of Polymerase Kappa: Confirmatory Assay for Cherry-picked Compounds | 2012 | PloS one, , Volume: 7, Issue:10
| A comprehensive strategy to discover inhibitors of the translesion synthesis DNA polymerase κ. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID588519 | A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities | 2011 | Antiviral research, Sep, Volume: 91, Issue:3
| High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors. |
| AID540299 | A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis | 2010 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
| Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. |
| AID1159550 | Human Phosphogluconate dehydrogenase (6PGD) Inhibitor Screening | 2015 | Nature cell biology, Nov, Volume: 17, Issue:11
| 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |