Page last updated: 2024-08-05 15:21:21

EC 2.7.1.33 (pantothenate kinase) inhibitor

An EC 2.7.1.* (phosphotransferases with an alcohol group as acceptor) inhibitor that interferes with the action of pantothenate kinase (EC 2.7.1.33).

ChEBI ID: 77194

Members (8)

MemberDefinitionClass
chloranilA member of the class of 1,4-benzoquiones that is 1,4-benzoquinone in which all four hydrogens are substituted by chlorines.tetrachloro-1,4-benzoquinone
dehydroepiandrosterone sulfateA steroid sulfate that is the 3-sulfooxy derivative of dehydroepiandrosterone.dehydroepiandrosterone sulfate
fusidic acidA steroid antibiotic that is isolated from the fermentation broth of Fusidium coccineum.fusidic acid
glipizideAn N-sulfonylurea that is glyburide in which the (5-chloro-2-methoxybenzoyl group is replaced by a (5-methylpyrazin-2-yl)carbonyl group. An oral hypoglycemic agent, it is used in the treatment of type 2 diabetes mellitus.glipizide
glyburideAn N-sulfonylurea that is acetohexamide in which the acetyl group is replaced by a 2-(5-chloro-2-methoxybenzamido)ethyl group.glyburide
pioglitazoneA member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity.pioglitazone
pregnenolone sulfatepregnenolone sulfate
tolfenamic acidAn aminobenzoic acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is replaced by a 3-chloro-2-methylphenyl group. Tolfenamic acid is used specifically for relieving the pain of migraine. It also shows anticancer activity.tolfenamic acid

Research

Studies (17,183)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-19902,545 (14.81)18.7374
1990's3,574 (20.80)18.2507
2000's5,247 (30.54)29.6817
2010's4,790 (27.88)24.3611
2020's1,027 (5.98)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials2,198 (11.91%)5.53%
Reviews1,234 (6.69%)6.00%
Case Studies732 (3.97%)4.05%
Observational54 (0.29%)0.25%
Other14,230 (77.14%)84.16%

Protein Targets (220)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1Homo sapiens (human)Potency7.990114
15-lipoxygenase, partialHomo sapiens (human)Potency0.158511
acetylcholinesteraseHomo sapiens (human)Potency55.908237
activating transcription factor 6Homo sapiens (human)Potency45.065524
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency9.029214
AR proteinHomo sapiens (human)Potency26.94401025
aryl hydrocarbon receptorHomo sapiens (human)Potency44.054724
ATAD5 protein, partialHomo sapiens (human)Potency32.629411
ATP-dependent phosphofructokinaseTrypanosoma brucei brucei TREU927Potency0.169411
Bloom syndrome protein isoform 1Homo sapiens (human)Potency75.059424
Cellular tumor antigen p53Homo sapiens (human)Potency20.804737
cellular tumor antigen p53 isoform aHomo sapiens (human)Potency18.317422
Chain A, 2-oxoglutarate OxygenaseHomo sapiens (human)Potency0.707911
Chain A, ATP-DEPENDENT DNA HELICASE Q1Homo sapiens (human)Potency31.622811
Chain A, Beta-lactamaseEscherichia coli K-12Potency14.125411
Chain A, Ferritin light chainEquus caballus (horse)Potency28.183811
Chain A, HADH2 proteinHomo sapiens (human)Potency0.692422
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency17.336315
Chain A, Putative fructose-1,6-bisphosphate aldolaseGiardia intestinalisPotency13.629514
Chain A, TYROSYL-DNA PHOSPHODIESTERASEHomo sapiens (human)Potency2.253612
Chain B, HADH2 proteinHomo sapiens (human)Potency0.692422
chromobox protein homolog 1Homo sapiens (human)Potency64.112023
cytochrome P450 2C19 precursorHomo sapiens (human)Potency8.783413
cytochrome P450 2C9 precursorHomo sapiens (human)Potency9.196516
cytochrome P450 2C9, partialHomo sapiens (human)Potency15.594715
cytochrome P450 2D6Homo sapiens (human)Potency26.835813
cytochrome P450 2D6 isoform 1Homo sapiens (human)Potency10.000011
cytochrome P450 3A4 isoform 1Homo sapiens (human)Potency8.3967215
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency4.605813
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency7.558614
Disintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)Potency10.000011
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency100.000011
DNA polymerase kappa isoform 1Homo sapiens (human)Potency35.481311
estrogen nuclear receptor alphaHomo sapiens (human)Potency33.4772820
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency46.751926
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency42.8256613
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency13.351515
EWS/FLI fusion proteinHomo sapiens (human)Potency14.098346
farnesoid X nuclear receptorHomo sapiens (human)Potency37.346044
GVesicular stomatitis virusPotency15.594715
GABA theta subunitRattus norvegicus (Norway rat)Potency8.120818
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)Potency8.120818
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)Potency8.120818
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)Potency8.120818
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)Potency8.120818
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)Potency8.120818
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)Potency8.120818
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)Potency8.120818
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)Potency8.120818
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)Potency8.120818
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)Potency8.120818
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)Potency8.120818
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)Potency8.120818
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)Potency8.120818
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)Potency8.120818
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)Potency8.120818
gemininHomo sapiens (human)Potency18.342413
GLI family zinc finger 3Homo sapiens (human)Potency18.4148311
GLS proteinHomo sapiens (human)Potency2.295123
glucocerebrosidaseHomo sapiens (human)Potency35.481311
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency24.6496512
Guanine nucleotide-binding protein GHomo sapiens (human)Potency22.196912
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)Homo sapiens (human)Potency42.800012
heat shock protein beta-1Homo sapiens (human)Potency12.760324
Histamine H2 receptorCavia porcellus (domestic guinea pig)Potency9.5358220
histone acetyltransferase KAT2A isoform 1Homo sapiens (human)Potency0.891311
Histone H2A.xCricetulus griseus (Chinese hamster)Potency33.215824
HLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)Potency15.594715
hypoxia-inducible factor 1 alpha subunitHomo sapiens (human)Potency16.492625
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)Homo sapiens (human)Potency10.018037
Inositol hexakisphosphate kinase 1Homo sapiens (human)Potency15.5947110
Inositol monophosphatase 1Rattus norvegicus (Norway rat)Potency21.810013
Integrin alpha-IIbHomo sapiens (human)Potency5.011911
Integrin beta-3Homo sapiens (human)Potency5.011911
Interferon betaHomo sapiens (human)Potency15.594715
interleukin 8Homo sapiens (human)Potency74.978011
lamin isoform A-delta10Homo sapiens (human)Potency6.129613
lethal factor (plasmid)Bacillus anthracis str. A2012Potency5.011911
LuciferasePhotinus pyralis (common eastern firefly)Potency20.529135
Microtubule-associated protein tauHomo sapiens (human)Potency24.557125
mitogen-activated protein kinase 1Homo sapiens (human)Potency10.000022
muscarinic acetylcholine receptor M1Rattus norvegicus (Norway rat)Potency22.387211
NFKB1 protein, partialHomo sapiens (human)Potency0.011222
nonstructural protein 1Influenza A virus (A/WSN/1933(H1N1))Potency17.782811
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency41.3677411
nuclear factor NF-kappa-B p105 subunit isoform 1Homo sapiens (human)Potency44.668411
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_aHomo sapiens (human)Potency31.676212
Nuclear receptor ROR-gammaHomo sapiens (human)Potency7.497811
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency23.120725
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency29.849323
parathyroid hormone/parathyroid hormone-related peptide receptor precursorHomo sapiens (human)Potency112.202011
ParkinHomo sapiens (human)Potency9.200011
peripheral myelin protein 22Rattus norvegicus (Norway rat)Potency0.002311
peripheral myelin protein 22 isoform 1Homo sapiens (human)Potency84.921411
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency16.0039412
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency29.470646
polyunsaturated fatty acid lipoxygenase ALOX12Homo sapiens (human)Potency1.778311
Polyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)Potency12.589311
potassium voltage-gated channel subfamily H member 2 isoform dHomo sapiens (human)Potency38.543713
pregnane X nuclear receptorHomo sapiens (human)Potency38.851626
progesterone receptorHomo sapiens (human)Potency23.854722
RAR-related orphan receptor gammaMus musculus (house mouse)Potency23.489428
regulator of G-protein signaling 4Homo sapiens (human)Potency2.119211
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency47.412837
retinoid X nuclear receptor alphaHomo sapiens (human)Potency21.446747
SMAD family member 2Homo sapiens (human)Potency33.1971210
SMAD family member 3Homo sapiens (human)Potency33.1971210
survival motor neuron protein isoform dHomo sapiens (human)Potency1.258912
TDP1 proteinHomo sapiens (human)Potency17.275627
thioredoxin glutathione reductaseSchistosoma mansoniPotency50.118711
thioredoxin reductaseRattus norvegicus (Norway rat)Potency2.993522
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency9.190326
thyroid hormone receptor beta isoform aHomo sapiens (human)Potency23.350722
thyroid stimulating hormone receptorHomo sapiens (human)Potency36.3285611
thyrotropin-releasing hormone receptorHomo sapiens (human)Potency33.714411
tyrosine-protein kinase YesHomo sapiens (human)Potency1.729111
ubiquitin carboxyl-terminal hydrolase 2 isoform aHomo sapiens (human)Potency10.000011
USP1 protein, partialHomo sapiens (human)Potency79.784223
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency10.809524
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency26.064758
vitamin D3 receptor isoform VDRAHomo sapiens (human)Potency33.397714
VprHuman immunodeficiency virus 1Potency12.589311

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)IC50100.000011
AcetylcholinesteraseHomo sapiens (human)Ki0.131726
Aldo-keto reductase family 1 member C3Homo sapiens (human)Ki0.008011
Amine oxidase [flavin-containing] AHomo sapiens (human)IC5035.069011
Amine oxidase [flavin-containing] A Rattus norvegicus (Norway rat)Ki0.270811
Amine oxidase [flavin-containing] BHomo sapiens (human)IC500.298022
Amine oxidase [flavin-containing] BHomo sapiens (human)Ki0.323433
Amine oxidase [flavin-containing] BRattus norvegicus (Norway rat)Ki0.856733
Androgen receptorHomo sapiens (human)IC5052.450022
ATP synthase subunit beta, mitochondrialBos taurus (cattle)IC50100.000011
ATP synthase subunit delta, mitochondrialBos taurus (cattle)IC50100.000011
ATP synthase subunit epsilon, mitochondrialBos taurus (cattle)IC50100.000011
ATP synthase subunit gamma, mitochondrialBos taurus (cattle)IC50100.000011
ATP-binding cassette sub-family C member 3Homo sapiens (human)IC50108.000014
ATP-binding cassette sub-family C member 8Homo sapiens (human)IC500.004311
ATP-binding cassette sub-family C member 9Homo sapiens (human)IC500.220011
ATP-sensitive inward rectifier potassium channel 11Homo sapiens (human)IC500.112222
Beta-lactamaseEscherichia coli K-12IC50300.000011
Bile salt export pumpHomo sapiens (human)IC5039.0275919
Bile salt export pumpRattus norvegicus (Norway rat)IC509.300035
Bile salt export pumpHomo sapiens (human)Ki27.500011
Bile salt export pumpRattus norvegicus (Norway rat)Ki4.150022
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)IC50117.333333
Canalicular multispecific organic anion transporter 1Homo sapiens (human)IC50133.000012
Canalicular multispecific organic anion transporter 1Rattus norvegicus (Norway rat)Ki8.700033
Carbonic anhydrase 2Homo sapiens (human)IC500.114011
Carnitine O-palmitoyltransferase 1, liver isoformHomo sapiens (human)IC5010.000011
Carnitine O-palmitoyltransferase 2, mitochondrialHomo sapiens (human)IC50100.000011
Carnitine O-palmitoyltransferase 2, mitochondrialRattus norvegicus (Norway rat)IC50100.000011
CDGSH iron-sulfur domain-containing protein 1Homo sapiens (human)IC5023.875012
CDGSH iron-sulfur domain-containing protein 1Rattus norvegicus (Norway rat)IC501.000011
CDGSH iron-sulfur domain-containing protein 1Homo sapiens (human)Ki1.020512
CDGSH iron-sulfur domain-containing protein 2Homo sapiens (human)IC504.800011
Chain A, Type Iii Chloramphenicol AcetyltransferaseShigella flexneriKi5.400011
Cholesterol 24-hydroxylaseHomo sapiens (human)Ki2.500011
Cholesteryl ester transfer proteinOryctolagus cuniculus (rabbit)IC50238.600011
CholinesteraseHomo sapiens (human)Ki0.149226
Chymotrypsinogen ABos taurus (cattle)IC50360.000011
Coagulation factor XIIHomo sapiens (human)Ki0.125415
Cocaine esteraseHomo sapiens (human)Ki0.057411
cysteine protease ATG4B isoform aHomo sapiens (human)IC508.170011
Cystic fibrosis transmembrane conductance regulatorHomo sapiens (human)IC5015.000011
Cytochrome c oxidase subunit 2Homo sapiens (human)IC501.290022
Cytochrome P450 2C9 Homo sapiens (human)IC501.602011
Cytochrome P450 2C9 Homo sapiens (human)Ki537,650,000,000.000011
Cytochrome P450 3A4Homo sapiens (human)IC507.447311
Enoyl-[acyl-carrier-protein] reductase [NADH] Francisella tularensis subsp. tularensis SCHU S4IC5079.000011
Fatty acid-binding protein, intestinalHomo sapiens (human)Ki6.100011
Glutamate receptor ionotropic, NMDA 2CHomo sapiens (human)IC50112.000011
Glutamate receptor ionotropic, NMDA 2DHomo sapiens (human)IC50118.000011
large T antigenBetapolyomavirus macacaeIC5020.420011
Liver carboxylesterase 1Homo sapiens (human)Ki0.118526
Liver carboxylesterase 1Oryctolagus cuniculus (rabbit)Ki0.113626
Malate dehydrogenase, cytoplasmicHomo sapiens (human)IC50400.000011
Multidrug resistance-associated protein 4Homo sapiens (human)IC5065.800025
NACHT, LRR and PYD domains-containing protein 3 Homo sapiens (human)IC5012.000011
NACHT, LRR and PYD domains-containing protein 3 Mus musculus (house mouse)IC5010.000011
Peroxisome proliferator-activated receptor alphaHomo sapiens (human)IC5010.000011
Peroxisome proliferator-activated receptor alphaMus musculus (house mouse)IC501.150011
Peroxisome proliferator-activated receptor gammaHomo sapiens (human)IC505.408188
Peroxisome proliferator-activated receptor gammaMus musculus (house mouse)IC500.700011
Peroxisome proliferator-activated receptor gammaRattus norvegicus (Norway rat)IC500.700011
Peroxisome proliferator-activated receptor gammaHomo sapiens (human)Ki0.585489
phospholipase A2 precursorHomo sapiens (human)IC507.740011
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)IC5074.065544
Prostaglandin G/H synthase 2Homo sapiens (human)IC500.880011
Replicase polyprotein 1abSevere acute respiratory syndrome coronavirus 2IC502.060022
Replicase polyprotein 1abSevere acute respiratory syndrome-related coronavirusIC504.100011
Solute carrier family 15 member 1Rattus norvegicus (Norway rat)Ki25.000011
Solute carrier family 15 member 2Rattus norvegicus (Norway rat)Ki7.800011
Solute carrier family 22 member 6Rattus norvegicus (Norway rat)Ki1.600011
Solute carrier family 22 member 7Rattus norvegicus (Norway rat)Ki12.300011
Solute carrier organic anion transporter family member 1B1Homo sapiens (human)IC508.200033
Steryl-sulfataseHomo sapiens (human)IC500.800011
Tyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)IC50220.000011

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
AlbuminHomo sapiens (human)Kd12.000011
Estrogen receptorRattus norvegicus (Norway rat)EC500.362012
Estrogen receptor betaRattus norvegicus (Norway rat)EC500.362012
Free fatty acid receptor 1Homo sapiens (human)EC50812.831011
G-protein coupled bile acid receptor 1Homo sapiens (human)EC50127.000011
Glutamate receptor ionotropic, NMDA 2AHomo sapiens (human)EC5027.500022
Glutamate receptor ionotropic, NMDA 2BHomo sapiens (human)EC5048.000022
Glutamate receptor ionotropic, NMDA 2CHomo sapiens (human)EC5083.000011
Glutamate receptor ionotropic, NMDA 2DHomo sapiens (human)EC5078.000011
glycogen synthase kinase-3 beta isoform 1Homo sapiens (human)EC50300.000011
Muscarinic acetylcholine receptor M1Rattus norvegicus (Norway rat)EC500.550012
Muscarinic acetylcholine receptor M2Rattus norvegicus (Norway rat)EC500.550012
Muscarinic acetylcholine receptor M3Rattus norvegicus (Norway rat)EC500.550012
Muscarinic acetylcholine receptor M4Rattus norvegicus (Norway rat)EC500.550012
Muscarinic acetylcholine receptor M5Rattus norvegicus (Norway rat)EC500.550012
Peroxisome proliferator-activated receptor alphaHomo sapiens (human)EC506.686733
Peroxisome proliferator-activated receptor gammaHomo sapiens (human)EC500.80273636
Peroxisome proliferator-activated receptor gammaMus musculus (house mouse)EC500.620022
Peroxisome proliferator-activated receptor gammaHomo sapiens (human)Kd0.871011
Potassium channel subfamily K member 2Homo sapiens (human)EC5064.000011
streptokinase A precursorStreptococcus pyogenes M1 GASEC500.269522
TransthyretinHomo sapiens (human)Kd0.150011

Other Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
ATP-binding cassette sub-family C member 11Homo sapiens (human)Km13.000011
Multidrug resistance-associated protein 1 Homo sapiens (human)Km5.000011
Multidrug resistance-associated protein 4Homo sapiens (human)Km1.900011
Peroxisome proliferator-activated receptor gammaHomo sapiens (human)Activity3.140022
Solute carrier family 22 member 11Homo sapiens (human)Km0.630011
Solute carrier organic anion transporter family member 1A1Mus musculus (house mouse)Km8.200011
Solute carrier organic anion transporter family member 1A1Rattus norvegicus (Norway rat)Km5.000011
Solute carrier organic anion transporter family member 1A2Homo sapiens (human)Km6.600011
Solute carrier organic anion transporter family member 1A3Rattus norvegicus (Norway rat)Km8.050022
Solute carrier organic anion transporter family member 1A4Rattus norvegicus (Norway rat)Km17.000011
Solute carrier organic anion transporter family member 1A5Rattus norvegicus (Norway rat)Km162.000011
Solute carrier organic anion transporter family member 1B1Homo sapiens (human)Km21.500011
Solute carrier organic anion transporter family member 1B2Rattus norvegicus (Norway rat)Km5.300011
Solute carrier organic anion transporter family member 1B3Homo sapiens (human)Km30.000011
Solute carrier organic anion transporter family member 2B1 Homo sapiens (human)Km6.260011
Steryl-sulfataseHomo sapiens (human)Km10.350022