Page last updated: 2024-09-27

Lead Poisoning, Nervous System

Injury to the nervous system secondary to exposure to lead compounds. Two distinct clinical patterns occur in children (LEAD POISONING, NERVOUS SYSTEM, CHILDHOOD) and adults (LEAD POISONING, NERVOUS SYSTEM, ADULT). In children, lead poisoning typically produces an encephalopathy. In adults, exposure to toxic levels of lead is associated with a peripheral neuropathy.

Synonyms(10)

Synonym
Lead Poisoning, Nervous System
Nervous System Diseases, Lead-Induced
Lead-Induced Nervous System Diseases
Plumbism, Nervous System
Poisoning, Lead, Neurologic
Plumbism, Neurologic
Neurotoxicity Syndrome, Lead
Nervous System Poisoning, Lead
Lead Poisoning, Neurologic
Poisoning, Lead, Nervous System

Research

Studies (111)

TimeframeStudies, This Condition (%)All Conditions %
pre-19901 (0.90)23.3326
1990's2 (1.80)12.5806
2000's51 (45.95)18.1394
2010's48 (43.24)28.8240
2020's9 (8.11)9.53
DrugIndicatedRelationship StrengthStudiesTrials
gamma-aminobutyric acid0low20
aminolevulinic acid0low10
salicylic acid0low10
gallic acid0low10
creatine0low10
formaldehyde0low10
glycine0low20
thioctic acid0low10
nitrates0low20
nitrites0low10
quinolinic acid0low10
taurine0low10
thiamine0low10
mercaptoethanol0low10
3-nitropropionic acid0low10
7-chlorokynurenic acid0low10
7-nitroindazole0low10
cimetidine0low10
amphetamine0low10
erythrosine0low10
ifenprodil0low20
kynurenic acid0low10
mecamylamine0low10
potassium chloride0low10
corticosterone0low10
thyroxine0low10
carbachol0low10
serine0low10
aspartic acid0low10
glutamine0low10
edetic acid0low20
tyrosine0low10
cysteamine0low10
methionine0low10
tetraethyl lead0low10
quinuclidines0low10
thiophenes0low10
aluminum acetate0low10
indazoles0low10
galantamine0low10
cyanamide0low10
methamphetamine0low20
malondialdehyde0low50
lead sulfide0low10
d-alpha tocopherol0low20
sabinene0low10
manganese0low20
mercury0low10
cadmium0low10
lead chloride0low10
lead nitrate0low10
phenyl acetate0low10
dihydro-beta-erythroidine0low10
transferrin0low10
glutamic acid0low10
captopril0low10
mibefradil0low10
n-acetylaspartic acid0low10
comenic acid0low10
nicotine0low10
vitamin b 60low10
methyllycaconitine0low10
tanshinone0low10
monoisoamyl-2,3-dimercaptosuccinate0low10
monensin0low10
acetyl coenzyme a0low10
retinol0low10
cocaine0low10
phorbol-12,13-didecanoate0low10
tolfenamic acid0low10
curcumin0low30
unithiol0low10
succimer0low50
thioperamide0low10
zinc protoporphyrin ix0low10
lead0medium790
aluminum0low20
arsenic0low10
phosphorus0low10
selenium0low10
dizocilpine maleate0low20
i(3)so3-galactosylceramide0low10
phosphocreatine0low10
g(m1) ganglioside0low10
cytochrome c-t0low10
tannins0low10
picrotoxin0low20
glycolipids0low10
piperidines0low30
heme0low20
ascorbic acid0low40
clay0low10
caseins0low10
vitamin b 120low10
aconitine0low10
deoxyguanosine0low10
guanosine triphosphate0low10
trypan blue0low10
8-hydroxy-2'-deoxyguanosine0low10

Protein Targets (1,013)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
acetylcholinesterase9009
thioredoxin reductase190019
RAR-related orphan receptor gamma120012
GLI family zinc finger 3100010
AR protein200020
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)7007
progesterone receptor7007
glucocorticoid receptor [Homo sapiens]110011
retinoic acid nuclear receptor alpha variant 1140014
retinoid X nuclear receptor alpha8008
estrogen-related nuclear receptor alpha130013
estrogen nuclear receptor alpha210021
vitamin D (1,25- dihydroxyvitamin D3) receptor9009
euchromatic histone-lysine N-methyltransferase 2320032
aryl hydrocarbon receptor7007
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a8008
thyrotropin-releasing hormone receptor4004
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a5005
v-jun sarcoma virus 17 oncogene homolog (avian)9009
Histone H2A.x6006
Bloom syndrome protein isoform 1140014
hemoglobin subunit beta2002
chromobox protein homolog 1140014
heat shock protein beta-16006
DNA polymerase iota isoform a (long)9009
geminin200020
muscarinic acetylcholine receptor M1110011
lamin isoform A-delta10210021
Voltage-dependent calcium channel gamma-2 subunit5005
Cellular tumor antigen p53120012
Delta-aminolevulinic acid dehydratase0101
Glutamate receptor 266115
Isocitrate lyase 10101
Isocitrate lyase0101
TAR DNA-binding protein 437007
Isocitrate lyase0101
Chain A, 2-oxoglutarate Oxygenase110011
cytochrome P450 2C9 precursor4004
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 18008
potassium voltage-gated channel subfamily H member 2 isoform d7007
mitogen-activated protein kinase 17007
lethal factor (plasmid)9009
Glutamate receptor 116110
Glutamate receptor 316110
Glutamate receptor 416110
Glutamate receptor ionotropic, kainate 10518
Glutamate receptor ionotropic, NMDA 1 015323
Glutamate receptor ionotropic, kainate 20518
Glutamate receptor ionotropic, kainate 30608
Histamine H2 receptor82111
Glutamate receptor ionotropic, NMDA 2A 014322
Glutamate receptor ionotropic, NMDA 2B014322
Glutamate receptor ionotropic, NMDA 2C014322
Glutamate receptor ionotropic, kainate 40507
Glutamate receptor ionotropic, NMDA 2D014322
Glutamate receptor ionotropic, kainate 50507
Vesicular glutamate transporter 30202
Glutamate receptor ionotropic, NMDA 3B014322
Glutamate receptor ionotropic, NMDA 3A014322
Chain A, HADH2 protein9009
Chain B, HADH2 protein9009
endonuclease IV2002
cytochrome P450 2C19 precursor9009
nuclear factor erythroid 2-related factor 2 isoform 25005
parathyroid hormone/parathyroid hormone-related peptide receptor precursor2002
flap endonuclease 19009
nuclear receptor ROR-gamma isoform 18008
survival motor neuron protein isoform d5005
muscleblind-like protein 1 isoform 13003
neuropeptide S receptor isoform A4004
Aromatase0101
Amine oxidase [flavin-containing] A 0101
Nitric oxide synthase, endothelial0101
Nitric oxide synthase, endothelial0102
Nitric oxide synthase, brain0203
Nitric oxide synthase, brain 0101
Nitric oxide synthase, inducible0202
Nitric oxide synthase, inducible0102
Nitric oxide synthase, endothelial 0101
Chain A, Avidin0022
Chain A, Avidin0022
Chain B, Avidin0022
N-alpha-acetyltransferase 500011
Chain A, Beta-lactamase4004
bromodomain adjacent to zinc finger domain 2B100010
Gamma-aminobutyric acid receptor subunit rho-10123
Glutamate receptor 10314
Glutamate receptor 20314
Glutamate receptor 30213
Solute carrier family 15 member 10101
Glutamate receptor 40314
Solute carrier family 15 member 10202
Solute carrier family 15 member 20101
Solute carrier family 22 member 30303
5-hydroxytryptamine receptor 2C0415
Phenylethanolamine N-methyltransferase0202
Cytochrome P450 2A60314
Substance-P receptor0101
5-hydroxytryptamine receptor 2A0415
5-hydroxytryptamine receptor 1A0415
Cytochrome P450 2A50202
Sodium-dependent dopamine transporter0516
5-hydroxytryptamine receptor 1B0314
5-hydroxytryptamine receptor 1D0314
5-hydroxytryptamine receptor 1F0314
5-hydroxytryptamine receptor 2B0415
5-hydroxytryptamine receptor 60213
5-hydroxytryptamine receptor 7 0213
5-hydroxytryptamine receptor 5A0213
5-hydroxytryptamine receptor 5B0213
5-hydroxytryptamine receptor 3A0213
Sigma non-opioid intracellular receptor 10213
5-hydroxytryptamine receptor 4 0213
Beta-2 adrenergic receptor0101
5-hydroxytryptamine receptor 3B0213
Sigma non-opioid intracellular receptor 10202
Chain A, Hyaluronidase, phage associated0101
thioredoxin glutathione reductase6006
cytochrome P450 family 3 subfamily A polypeptide 49009
IDH15005
thyroid hormone receptor beta isoform 2110011
nuclear factor erythroid 2-related factor 2 isoform 1110011
lethal(3)malignant brain tumor-like protein 1 isoform I4004
Polyphenol oxidase 20204
Pancreatic alpha-amylase0202
Albumin0101
Urease0101
Prolyl 4-hydroxylase subunit alpha-10001
Tyrosinase0202
Alpha-2B adrenergic receptor0011
Spike glycoprotein1001
Hyaluronate lyase0101
Prolyl hydroxylase EGLN20001
Egl nine homolog 10001
Prolyl hydroxylase EGLN30001
Hypoxia-inducible factor 1-alpha inhibitor0001
Solute carrier family 23 member 10101
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE110011
Chain A, TYROSYL-DNA PHOSPHODIESTERASE8008
Chain A, Ferritin light chain4004
phosphopantetheinyl transferase130013
aldehyde dehydrogenase 1 family, member A1140014
arylsulfatase A120012
Metabotropic glutamate receptor 60124
Excitatory amino acid transporter 40202
Glutamate transporter homolog0011
Carbonic anhydrase 108013
Carbonic anhydrase 208013
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase0101
5-hydroxytryptamine receptor 1D0001
Excitatory amino acid transporter 10304
Excitatory amino acid transporter 20304
Excitatory amino acid transporter 30304
Metabotropic glutamate receptor 10124
Metabotropic glutamate receptor 20124
Carbonic anhydrase-like protein, putative0005
Carbonic anhydrase 40001
Acetylcholinesterase0505
Aldo-keto reductase family 1 member B100101
Aldo-keto reductase family 1 member B10303
CPG DNA methylase0101
Prostaglandin G/H synthase 20507
Multidrug resistance protein CDR10101
Lactoylglutathione lyase0303
Integrase 0202
Calcium/calmodulin-dependent protein kinase type II subunit alpha0101
Chain A, angiotensin converting enzyme0101
Chain A, angiotensin converting enzyme0101
15-lipoxygenase, partial8008
Microtubule-associated protein tau120012
Thrombopoietin5005
Metallo-beta-lactamase type 20112
peripheral myelin protein 22 isoform 13003
M-phase phosphoprotein 84004
transient receptor potential cation channel subfamily V member 11001
ATP-binding cassette sub-family C member 30404
Multidrug resistance-associated protein 40404
Bile salt export pump0707
Prothrombin0112
Renin0101
Neprilysin0101
Neprilysin0101
Leukotriene A-4 hydrolase0213
EEF1AKMT4-ECE2 readthrough transcript protein0101
Angiotensin-converting enzyme 0415
Angiotensin-converting enzyme0203
Leukotriene A-4 hydrolase0101
Thymidine phosphorylase0011
Prostaglandin G/H synthase 10202
Endothelin-converting enzyme 10101
Succinyl-diaminopimelate desuccinylase0202
Angiotensin-converting enzyme0202
Beta-lactamase TEM0101
Mu-type opioid receptor0123
Beta-lactamase 0304
Canalicular multispecific organic anion transporter 10404
Beta-lactamase 0303
Angiotensin-converting enzyme 2 0101
Beta-lactamase class B VIM-2 0112
ATP-dependent phosphofructokinase100010
GALC protein3003
TDP1 protein180018
peroxisome proliferator activated receptor gamma7007
thyroid stimulating hormone receptor8008
Neuronal acetylcholine receptor subunit alpha-30539
Muscarinic acetylcholine receptor M20225
Muscarinic acetylcholine receptor M40225
Muscarinic acetylcholine receptor M10417
Muscarinic acetylcholine receptor M30416
Muscarinic acetylcholine receptor M40405
Muscarinic acetylcholine receptor M50304
Muscarinic acetylcholine receptor M50225
Neuronal acetylcholine receptor subunit alpha-40539
Muscarinic acetylcholine receptor M20304
Muscarinic acetylcholine receptor M10225
Neuronal acetylcholine receptor subunit alpha-20337
Neuronal acetylcholine receptor subunit beta-20539
Neuronal acetylcholine receptor subunit beta-30337
Neuronal acetylcholine receptor subunit beta-40539
Muscarinic acetylcholine receptor M10112
Muscarinic acetylcholine receptor M30225
Neuronal acetylcholine receptor subunit alpha-50337
Delta-type opioid receptor0203
Neuronal acetylcholine receptor subunit alpha-60337
Neuronal acetylcholine receptor subunit alpha-90337
Neuronal acetylcholine receptor subunit alpha-70337
Muscarinic acetylcholine receptor0202
Muscarinic acetylcholine receptor M30013
Muscarinic acetylcholine receptor M20003
Neuronal acetylcholine receptor subunit alpha-100337
interleukin 85005
thyroid stimulating hormone receptor100010
G7007
cytochrome P450 2D64004
alpha-galactosidase2002
DNA polymerase kappa isoform 1120012
peripheral myelin protein 225005
cytochrome P450 3A4 isoform 1100010
Solute carrier family 22 member 10101
Gamma-aminobutyric acid receptor subunit pi102012
Solute carrier family 22 member 20304
Solute carrier family 22 member 1 0507
Solute carrier family 22 member 60303
Solute carrier family 22 member 20101
cGMP-specific 3',5'-cyclic phosphodiesterase0101
Interferon beta7007
HLA class I histocompatibility antigen, B alpha chain 7007
ATP-dependent translocase ABCB10202
ATP-dependent translocase ABCB10202
Cytochrome P450 3A40607
Cytochrome P450 2D60202
Cytochrome P450 2C9 0303
Gamma-aminobutyric acid receptor subunit beta-1102012
Gamma-aminobutyric acid receptor subunit delta102012
Gamma-aminobutyric acid receptor subunit gamma-2102113
Gamma-aminobutyric acid receptor subunit alpha-5102012
Gamma-aminobutyric acid receptor subunit alpha-3102012
Potassium-transporting ATPase alpha chain 10101
ATP-dependent translocase ABCB10202
Gamma-aminobutyric acid receptor subunit gamma-1102012
Gamma-aminobutyric acid receptor subunit alpha-2102012
Histamine H2 receptor0303
Gamma-aminobutyric acid receptor subunit alpha-4102012
Gamma-aminobutyric acid receptor subunit gamma-3102012
Gamma-aminobutyric acid receptor subunit alpha-6102012
Histamine H1 receptor0112
Potassium-transporting ATPase subunit beta0101
Cytochrome P450 2J20202
Gamma-aminobutyric acid receptor subunit alpha-1102113
Gamma-aminobutyric acid receptor subunit beta-3102012
Gamma-aminobutyric acid receptor subunit beta-2102113
Aldehyde oxidase0101
Solute carrier family 22 member 60202
Solute carrier family 22 member 10606
Multidrug and toxin extrusion protein 20101
Solute carrier family 22 member 80304
GABA theta subunit102012
Inositol hexakisphosphate kinase 17007
Multidrug and toxin extrusion protein 10101
Gamma-aminobutyric acid receptor subunit epsilon102012
Histamine H4 receptor0316
Solute carrier family 22 member 110101
Solute carrier family 22 member 20606
Solute carrier family 22 member 40101
Solute carrier family 22 member 80202
cytochrome P450 2C9, partial7007
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION0011
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION0011
Chain H, Fab M82G2, Heavy chain0011
Chain L, Fab M82G2, Light chain0011
Chain H, Fab M82g2, Heavy Chain0011
Chain L, Fab M82g2, Light Chain0011
Gamma-aminobutyric acid receptor subunit pi0202
Gamma-aminobutyric acid receptor subunit delta0202
Amyloid-beta precursor protein0506
Fatty acid-binding protein, heart0101
Muscarinic acetylcholine receptor M20112
Tryptophan 5-hydroxylase 10101
Gamma-aminobutyric acid receptor subunit alpha-10314
Gamma-aminobutyric acid receptor subunit beta-10314
Gamma-aminobutyric acid receptor subunit gamma-20213
D0203
Alpha-2B adrenergic receptor0101
Alpha-2C adrenergic receptor0101
Alpha-2A adrenergic receptor0101
Liver carboxylesterase 10102
Sodium-dependent noradrenaline transporter 0213
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
Gamma-aminobutyric acid receptor subunit beta-30314
Gamma-aminobutyric acid receptor subunit alpha-50314
Sodium-dependent serotonin transporter0213
Sodium-dependent serotonin transporter0203
Gamma-aminobutyric acid receptor subunit alpha-30314
Lysosomal Pro-X carboxypeptidase0101
Gamma-aminobutyric acid receptor subunit alpha-20314
Gamma-aminobutyric acid receptor subunit beta-20314
Gamma-aminobutyric acid receptor subunit alpha-40314
D(2) dopamine receptor0529
Gamma-aminobutyric acid receptor subunit epsilon0202
Sodium-dependent dopamine transporter 0202
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
Potassium voltage-gated channel subfamily H member 20505
Leukotriene B4 receptor 10101
Gamma-aminobutyric acid receptor subunit alpha-60314
Sodium-dependent dopamine transporter0202
Gamma-aminobutyric acid receptor subunit gamma-10202
Sigma non-opioid intracellular receptor 10505
Gamma-aminobutyric acid receptor subunit gamma-30202
Leukotriene B4 receptor 20101
Gamma-aminobutyric acid receptor subunit theta0202
Transporter0315
pregnane X receptor4004
NFKB1 protein, partial3003
nonstructural protein 12002
farnesoid X nuclear receptor4004
pregnane X nuclear receptor7007
thyroid hormone receptor beta isoform a7007
serine/threonine-protein kinase mTOR isoform 13003
Solute carrier family 22 member 30101
Sex hormone-binding globulin0011
Corticosteroid-binding globulin0101
Mineralocorticoid receptor 0011
Androgen receptor0101
C-8 sterol isomerase0101
Solute carrier organic anion transporter family member 1A10101
Nuclear receptor ROR-gamma5005
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0101
Sodium- and chloride-dependent creatine transporter 10101
Proton-coupled amino acid transporter 10505
Chain A, Breast cancer type 1 susceptibility protein1001
Chain A, Putative fructose-1,6-bisphosphate aldolase6006
Chain A, JmjC domain-containing histone demethylation protein 3A5005
Chain A, Cruzipain3003
Luciferase7007
Nrf21001
hypoxia-inducible factor 1 alpha subunit3003
SMAD family member 25005
ATAD5 protein, partial7007
USP1 protein, partial8008
GLS protein100010
SMAD family member 35005
alkaline phosphatase, intestinal0101
Smad32002
apical membrane antigen 1, AMA13003
caspase 7, apoptosis-related cysteine protease1001
PINK11001
estrogen receptor 2 (ER beta)3003
nuclear receptor subfamily 1, group I, member 35005
EWS/FLI fusion protein4005
glucocerebrosidase5005
Parkin2002
toll-like receptor 90101
peroxisome proliferator-activated receptor delta5005
caspase-31001
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)3003
TPA: protein transporter TIM100101
activating transcription factor 64004
lysosomal alpha-glucosidase preproprotein3003
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein0101
cellular tumor antigen p53 isoform a4004
polyunsaturated fatty acid lipoxygenase ALOX121001
perilipin-50101
vitamin D3 receptor isoform VDRA8008
intestinal alkaline phosphatase precursor0101
perilipin-10101
transcriptional regulator ERG isoform 33003
huntingtin isoform 21001
importin subunit beta-1 isoform 12002
pyruvate kinase PKM isoform a1001
DNA polymerase beta4004
nuclear factor NF-kappa-B p105 subunit isoform 11001
snurportin-12002
histone-lysine N-methyltransferase 2A isoform 2 precursor6006
peptidyl-prolyl cis-trans isomerase NIMA-interacting 16006
tumor susceptibility gene 101 protein1001
GTP-binding nuclear protein Ran isoform 12002
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a0101
DNA dC->dU-editing enzyme APOBEC-3G isoform 11102
alkaline phosphatase, germ cell type preproprotein0101
caspase-1 isoform alpha precursor2002
hypothetical protein SA14220101
DNA dC->dU-editing enzyme APOBEC-3F isoform a1001
Prostaglandin E synthase0101
Polyunsaturated fatty acid lipoxygenase ALOX15B5005
Histone deacetylase 30202
Lysine-specific histone demethylase 1A0202
D-amino-acid oxidase0101
Phospholipase A20101
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10202
Integrin beta-33014
Neuronal proto-oncogene tyrosine-protein kinase Src 0101
Prostaglandin G/H synthase 10101
Cholinesterase0404
Heme oxygenase 1 0101
Integrin alpha-IIb3014
Glutathione S-transferase P0202
Polyunsaturated fatty acid 5-lipoxygenase0101
60 kDa chaperonin0202
Replicase polyprotein 1ab0314
Replicase polyprotein 1ab0415
Microtubule-associated protein tau0102
60 kDa heat shock protein, mitochondrial0202
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 0101
Tissue factor0101
Aminopeptidase N0101
Aminopeptidase N0101
Alpha-1B adrenergic receptor0202
Sarcoplasmic/endoplasmic reticulum calcium ATPase 20202
Glycogen synthase kinase-3 beta0101
Amine oxidase [flavin-containing] A0202
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Acetylcholinesterase0719
Heme oxygenase 20101
Alpha-1D adrenergic receptor0202
Amine oxidase [flavin-containing] B0202
Voltage-dependent L-type calcium channel subunit alpha-1D0101
Proteasome subunit beta type-50202
17-beta-hydroxysteroid dehydrogenase type 20101
Alpha-synuclein2316
Alpha-1A adrenergic receptor0202
Glycogen synthase kinase-3 beta0101
Caspase-72002
Histone deacetylase 40202
Beta-secretase 10202
10 kDa heat shock protein, mitochondrial0202
Guanine nucleotide-binding protein G2002
Cholinesterase0404
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Histone acetyltransferase p3000101
Serine/threonine-protein kinase PAK 10101
Histone deacetylase 10303
5-hydroxytryptamine receptor 40011
Sodium/bile acid cotransporter0011
Nuclear factor erythroid 2-related factor 20011
Thiosulfate sulfurtransferase0202
Thioredoxin reductase 1, cytoplasmic0101
60 kDa chaperonin 0202
10 kDa chaperonin 0202
Thioredoxin reductase 30101
Sortase A0202
Histone deacetylase 70202
Histone deacetylase 20303
CREB-binding protein0101
Sarcoplasmic/endoplasmic reticulum calcium ATPase 30202
Cysteine protease 0101
Polyamine deacetylase HDAC100202
Histone deacetylase 11 0202
NACHT, LRR and PYD domains-containing protein 3 0101
ATPase family AAA domain-containing protein 51001
Ataxin-23003
Histone deacetylase 80303
Thioredoxin reductase 2, mitochondrial0101
CDGSH iron-sulfur domain-containing protein 10202
Histone deacetylase 60202
Histone deacetylase 90202
Broad substrate specificity ATP-binding cassette transporter ABCG20202
Histone deacetylase 50202
Lymphocyte antigen 960011
Beta lactamase (plasmid)0101
regulator of G-protein signaling 48008
Histone-lysine N-methyltransferase EHMT20101
Glutaminyl-peptide cyclotransferase0202
Histone-lysine N-methyltransferase EHMT10101
Rap guanine nucleotide exchange factor 33003
Alpha-tocopherol transfer protein0011
67.9K protein5005
Thymidine kinase, cytosolic0102
Deoxycytidine kinase0001
AAA family ATPase 0001
Sterol O-acyltransferase 10101
Neuronal acetylcholine receptor subunit beta-20517
Neuronal acetylcholine receptor subunit alpha-50112
Neuronal acetylcholine receptor subunit alpha-70527
Neuronal acetylcholine receptor subunit alpha-40517
Neuronal acetylcholine receptor subunit beta-40303
Neuronal acetylcholine receptor subunit beta-20314
Eyes absent homolog 20101
Metallo-beta-lactamase VIM-130101
Beta-lactamase VIM-1 0101
Chain A, ATP-DEPENDENT DNA HELICASE Q13003
Genome polyprotein 0112
chaperonin-containing TCP-1 beta subunit homolog2002
Fumarate hydratase2002
hypothetical protein, conserved2002
polyprotein2002
ubiquitin carboxyl-terminal hydrolase 2 isoform a4004
eyes absent homolog 2 isoform a2002
histone acetyltransferase KAT2A isoform 16006
relaxin receptor 1 isoform 11001
Flavin reductase (NADPH)0011
large T antigen0101
cytochrome P450 2D6 isoform 13003
D(2) dopamine receptor0415
D(4) dopamine receptor0214
D(3) dopamine receptor0213
D(2) dopamine receptor0101
Chain A, ACETYLCHOLINESTERASE0101
Chain A, Acetylcholinesterase0101
Acetylcholinesterase0202
Vascular endothelial growth factor receptor 1 0101
Acetylcholinesterase0101
Acetylcholinesterase 0101
Vascular endothelial growth factor receptor 30101
Vascular endothelial growth factor receptor 20101
Acetylcholinesterase0101
Kappa-type opioid receptor0101
Prolyl endopeptidase0101
Small conductance calcium-activated potassium channel protein 30101
Carboxylic ester hydrolase 0202
fructose-bisphosphate aldolase A1001
glyceraldehyde-3-phosphate dehydrogenase isoform 11001
Carbonic anhydrase 120204
Pancreatic triacylglycerol lipase0202
Urokinase-type plasminogen activator0101
Tissue-type plasminogen activator0101
Plasminogen activator inhibitor 10101
Urokinase-type plasminogen activator0101
Carbonic anhydrase 30204
72 kDa type IV collagenase0101
Matrilysin0101
L-selectin0101
P-selectin0101
E-selectin0101
Prolyl 4-hydroxylase subunit alpha-10202
Carbonic anhydrase 40608
Carbonic anhydrase 60305
Adenosine receptor A10102
Dipeptidyl peptidase 40112
Adenosine receptor A2a0203
Carbonic anhydrase 5A, mitochondrial0305
Carbonic anhydrase 70204
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT60101
Squalene monooxygenase 0101
Autoinducer 2-binding periplasmic protein LuxP0101
Anthrax toxin receptor 20101
Disintegrin and metalloproteinase domain-containing protein 172103
Lactoperoxidase0001
Polypeptide N-acetylgalactosaminyltransferase 20112
Alpha-(1,3)-fucosyltransferase 70101
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 10101
Carbonic anhydrase 90305
Carbonic anhydrase0202
Reverse transcriptase/RNaseH 0101
Carbonic anhydrase 130203
Toll-like receptor 2 0101
Carbonic anhydrase 140204
Carbonic anhydrase 5B, mitochondrial0204
Gamma-aminobutyric acid 0011
Gamma-aminobutyric acid receptor subunit rho-30011
Hsf1 protein0011
D(1A) dopamine receptor5005
Gamma-aminobutyric acid type B receptor subunit 20011
Gamma-aminobutyric acid type B receptor subunit 20101
Gamma-aminobutyric acid receptor subunit alpha-60011
Gamma-aminobutyric acid receptor subunit gamma-20011
Gamma-aminobutyric acid receptor subunit delta0011
Sodium- and chloride-dependent GABA transporter 10101
Gamma-aminobutyric acid receptor subunit alpha-20011
Gamma-aminobutyric acid receptor subunit alpha-30011
Gamma-aminobutyric acid receptor subunit gamma-30011
Gamma-aminobutyric acid receptor subunit rho-20011
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent taurine transporter0202
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent GABA transporter 20202
Sodium- and chloride-dependent GABA transporter 30202
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit beta-10011
Gamma-aminobutyric acid receptor subunit alpha-10011
Gamma-aminobutyric acid receptor subunit beta-30011
4-aminobutyrate aminotransferase, mitochondrial0001
4-aminobutyrate aminotransferase, mitochondrial0001
Sterol O-acyltransferase 10011
Gamma-aminobutyric acid receptor subunit alpha-50011
Gamma-aminobutyric acid receptor subunit pi0011
Gamma-aminobutyric acid receptor subunit alpha-40011
Platelet glycoprotein VI0011
Gamma-aminobutyric acid receptor subunit theta0011
Sodium- and chloride-dependent GABA transporter 20101
Gamma-aminobutyric acid receptor subunit gamma-10011
Gamma-aminobutyric acid type B receptor subunit 10011
Gamma-aminobutyric acid type B receptor subunit 10101
Chain A, GLUTAMATE RECEPTOR SUBUNIT 20101
Chain A, Glutamate Receptor Subunit 20101
Chain B, Glutamate Receptor Subunit 20101
Chain A, Slr1257 protein0011
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]0101
glp-1 receptor, partial1001
beta-2 adrenergic receptor1001
Metabotropic glutamate receptor 80202
Glutamate receptor ionotropic, NMDA 2D0303
Glutamate receptor ionotropic, NMDA 3B0202
Glutathione reductase, mitochondrial0202
Bifunctional aspartokinase/homoserine dehydrogenase 10101
ATP-citrate synthase 0101
Metabotropic glutamate receptor 10112
Metabotropic glutamate receptor 20011
Metabotropic glutamate receptor 30011
Metabotropic glutamate receptor 40112
Metabotropic glutamate receptor 50011
Metabotropic glutamate receptor 60011
Metabotropic glutamate receptor 70011
Glutamate receptor ionotropic, kainate 10112
Metabotropic glutamate receptor 50124
Metabotropic glutamate receptor 80011
Excitatory amino acid transporter 3 0001
Glutamate racemase0001
Metabotropic glutamate receptor 80112
Fatty-acid amide hydrolase 10101
Glutamate carboxypeptidase 20101
Glutamate receptor ionotropic, NMDA 10404
Glutamate receptor ionotropic, NMDA 2A0303
Glutamate receptor ionotropic, kainate 20112
Glutamate receptor ionotropic, kainate 30101
Glutamate receptor ionotropic, NMDA 2B0404
Metabotropic glutamate receptor 70113
Metabotropic glutamate receptor 30113
Metabotropic glutamate receptor 40113
Glutamate receptor ionotropic, NMDA 2C0303
Glutamate receptor ionotropic, kainate 50101
Glutamate racemase0001
Prolyl 4-hydroxylase0101
Glutamate receptor ionotropic, NMDA 3A0202
Alpha-ketoglutarate-dependent dioxygenase FTO0101
Chain A, Glutamine Binding Protein0011
Neutral amino acid transporter A0202
Asc-type amino acid transporter 10101
Neutral amino acid transporter B(0)0202
Amino acid transporter0202
Glycine receptor subunit alpha-10011
Sodium- and chloride-dependent glycine transporter 10101
Large neutral amino acids transporter small subunit 10404
Serine racemase0101
Olfactory receptor 51E20011
Sodium- and chloride-dependent glycine transporter 20101
Chain A, Uracil Phosphoribosyltransferase0011
Chain B, Uracil Phosphoribosyltransferase0011
Chain C, Uracil Phosphoribosyltransferase0011
2-dehydropantoate 2-reductase0011
Ras-related protein Rab-7a0011
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 90202
N(G),N(G)-dimethylarginine dimethylaminohydrolase 10101
ras-related protein Rab-9A2002
Delta-type opioid receptor0202
Histamine H1 receptor0202
Mu-type opioid receptor0101
D(1A) dopamine receptor2103
Sigma intracellular receptor 20101
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0101
D0101
5-hydroxytryptamine receptor 1A0101
5-hydroxytryptamine receptor 2A0101
Chain A, Cell Division Protein Kinase 20101
Chain A, CELL DIVISION PROTEIN KINASE 20101
Chain A, Cell Division Protein Kinase 20101
Chain A, CELL DIVISION PROTEIN KINASE 20101
Chain A, CELL DIVISION PROTEIN KINASE 20101
Chain A, CELL DIVISION PROTEIN KINASE 20101
Chain A, CELL DIVISION PROTEIN KINASE 20101
Chain A, CELL DIVISION PROTEIN KINASE 20101
Chain A, CELL DIVISION PROTEIN KINASE 20101
Chain A, CELL DIVISION PROTEIN KINASE 20101
Chain A, CELL DIVISION PROTEIN KINASE 20101
Chain A, CELL DIVISION PROTEIN KINASE 20101
Chain A, CELL DIVISION PROTEIN KINASE 20101
Chain A, Cell Division Protein Kinase 20101
DNA repair and recombination protein RadA0011
Cyclin-dependent kinase 10101
Heat shock protein HSP 90-alpha0011
G2/mitotic-specific cyclin-B10101
Indoleamine 2,3-dioxygenase 10113
Cyclin-A20101
Cyclin-dependent kinase 20101
RAC-alpha serine/threonine-protein kinase0101
Cyclin-A10101
Mitogen-activated protein kinase 130101
Aryl hydrocarbon receptor0011
Mitogen-activated protein kinase 120101
Mitogen-activated protein kinase 110101
Mitogen-activated protein kinase 140202
G protein-coupled receptor GPR350011
G-protein coupled receptor 350325
Histamine H3 receptor0112
Acetylcholine receptor subunit alpha0224
Acetylcholine receptor subunit gamma0224
Acetylcholine receptor subunit beta0224
Neuronal acetylcholine receptor subunit beta-40315
Neuronal acetylcholine receptor subunit alpha-30314
Acetylcholine receptor subunit epsilon0022
Acetylcholine receptor subunit delta0224
Neuronal acetylcholine receptor subunit alpha-20202
Amine oxidase [flavin-containing] B0101
Amine oxidase [flavin-containing] B0101
Synaptic vesicular amine transporter0101
Trace amine-associated receptor 10011
Trace amine-associated receptor 10011
Trace amine-associated receptor 10011
Trace amine-associated receptor 10011
Chain A, Methionyl-tRNA synthetase0011
Chain A, Methionyl-tRNA synthetase0011
Chain A, Aminopeptidase0101
Chain A, Methionine aminopeptidase0101
S-ribosylhomocysteine lyase0101
Adenylate cyclase type 50001
S-adenosylmethionine synthase isoform type-10001
S-adenosylmethionine synthase isoform type-20001
Fatty acid synthase0101
NPC intracellular cholesterol transporter 1 precursor1001
atrial natriuretic peptide receptor 2 precursor1001
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Voltage-dependent T-type calcium channel subunit alpha-1G0101
Voltage-dependent L-type calcium channel subunit alpha-1F0101
Potassium channel subfamily K member 20011
Voltage-dependent T-type calcium channel subunit alpha-1H0101
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 4 subunit alpha0101
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 4 subunit alpha0101
Voltage-dependent L-type calcium channel subunit beta-30101
Voltage-dependent N-type calcium channel subunit alpha-1B0101
Sodium channel protein type 7 subunit alpha0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
Voltage-dependent N-type calcium channel subunit alpha-1B0101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Sodium channel protein type 5 subunit alpha0101
Sodium channel protein type 9 subunit alpha0101
Calcium release-activated calcium channel protein 10101
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
Voltage-dependent T-type calcium channel subunit alpha-1I0101
Sodium channel protein type 11 subunit alpha0101
Sodium channel protein type 8 subunit alpha0101
Sodium channel protein type 10 subunit alpha0101
Mcl-10101
DNA polymerase III, partial1001
pyruvate kinase1001
hexokinase-4 isoform 11001
microphthalmia-associated transcription factor isoform 90101
estrogen receptor beta isoform 10101
glucokinase regulatory protein1001
DNA polymerase eta isoform 13003
Cationic trypsin0101
Protein E60101
Interstitial collagenase0101
Tubulin beta-4A chain0011
Tubulin beta chain0011
Tyrosine-protein kinase Yes0101
Adenosine receptor A30101
Tubulin alpha-3C chain0011
Islet amyloid polypeptide0101
Low molecular weight phosphotyrosine protein phosphatase0101
Serine/threonine-protein kinase pim-10101
Casein kinase II subunit alpha'0101
DNA-3-methyladenine glycosylase0101
Tyrosine-protein kinase SYK0112
Xanthine dehydrogenase/oxidase0101
Serine/threonine-protein kinase PLK10101
Death-associated protein kinase 10101
Mitogen-activated protein kinase 100101
Casein kinase II subunit beta0101
Tubulin alpha-1B chain0011
Tubulin alpha-4A chain0011
Tubulin beta-4B chain0011
Casein kinase II subunit alpha0101
Receptor-type tyrosine-protein phosphatase S0101
C-terminal-binding protein 11001
Tubulin beta-3 chain0011
Tubulin beta-2A chain0011
Carbonic anhydrase 30101
Solute carrier family 22 member 120101
Tubulin beta-8 chain0011
Tubulin alpha-3E chain0011
Tubulin alpha-1A chain0011
Casein kinase II subunit alpha 30101
Histone-lysine N-methyltransferase SETD70101
Enoyl-acyl-carrier protein reductase 0101
3-oxoacyl-acyl-carrier protein reductase 0101
Beta-hydroxyacyl-ACP dehydratase precursor (Fatty acid synthesis protein)0101
Aurora kinase B0101
Solute carrier family 22 member 120202
Tubulin alpha-1C chain0011
Tubulin beta-6 chain0011
Tubulin beta-2B chain0011
Tubulin beta-1 chain0011
Dipeptidyl peptidase 30101
Class A sortase SrtA 0101
phosphoglycerate kinase1001
Solute carrier family 22 member 200202
Solute carrier family 22 member 60202
Rap guanine nucleotide exchange factor 41001
5-hydroxytryptamine receptor 3E0101
Neuronal acetylcholine receptor subunit alpha-40213
Transient receptor potential cation channel subfamily A member 10011
5-hydroxytryptamine receptor 3B0101
Acetylcholine receptor subunit alpha0213
Acetylcholine receptor subunit beta0213
Acetylcholine receptor subunit gamma0213
Acetylcholine receptor subunit delta0213
Cytochrome P450 1A20101
Neuronal acetylcholine receptor subunit alpha-40101
Translocator protein0101
Acetylcholine receptor subunit beta-like 20202
Muscarinic acetylcholine receptor M40101
Mu-type opioid receptor0101
5-hydroxytryptamine receptor 3A0101
Neuronal acetylcholine receptor subunit alpha-70202
Acetylcholine-binding protein0112
Inositol monophosphatase 12002
Neuronal acetylcholine receptor subunit beta-30112
Neuronal acetylcholine receptor subunit alpha-60112
Cytochrome P450 2A130112
Neuronal acetylcholine receptor subunit alpha-50202
Liver carboxylesterase B-10101
5-hydroxytryptamine receptor 3D0101
Transient receptor potential cation channel subfamily A member 10011
Neuronal acetylcholine receptor subunit beta-30202
Neuronal acetylcholine receptor subunit alpha-30202
Soluble acetylcholine receptor0101
5-hydroxytryptamine receptor 3C0101
Neuronal acetylcholine receptor subunit alpha-20202
Neuronal acetylcholine receptor subunit alpha-60202
Integrin beta0011
Glycoprotein IIb0011
Carbonic anhydrase0204
Sodium/iodide cotransporter0101
Carbonic anhydrase 150305
Taste receptor type 2 member 310011
Taste receptor type 2 member 600011
Sodium/potassium/calcium exchanger 40112
Taste receptor type 2 member 140012
Taste receptor type 2 member 130011
Taste receptor type 2 member 90011
Taste receptor type 2 member 40011
Sodium/potassium/calcium exchanger 20112
Lysine-specific demethylase 4E0101
runt-related transcription factor 1 isoform AML1b1001
core-binding factor subunit beta isoform 21001
Advanced glycosylation end product-specific receptor0011
Beta-lactamase 0101
Advanced glycosylation end product-specific receptor0011
dopamine D1 receptor1001
interferon gamma precursor0001
Beta-2 adrenergic receptor0101
5-hydroxytryptamine receptor 1A0011
D(3) dopamine receptor0114
D(2) dopamine receptor0101
D(1A) dopamine receptor0101
5-hydroxytryptamine receptor 2A0101
Dipeptidyl peptidase 40011
Adenosine receptor A2a0011
5-hydroxytryptamine receptor 2A0112
D0101
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR0011
Retinol-binding protein 40011
Beta-lactoglobulin0011
Chain A, Lysr-type Regulatory Protein0011
Chain A, Lysr-type Regulatory Protein0011
Chain A, Lysr-type Regulatory Protein0011
Chain A, 146aa long hypothetical transcriptional regulator0011
Chain A, Anthranilate phosphoribosyltransferase0101
Chain A, Anthranilate phosphoribosyltransferase0101
Chain A, Anthranilate phosphoribosyltransferase0101
Chain B, Anthranilate phosphoribosyltransferase0101
Chain C, Anthranilate phosphoribosyltransferase0101
Chain A, Anthranilate phosphoribosyltransferase0101
Anthranilate phosphoribosyltransferase0101
Estrogen receptor beta0001
Inhibitor of nuclear factor kappa-B kinase subunit beta0001
5'-AMP-activated protein kinase subunit beta-20001
Bile salt export pump0101
Albumin0101
Polymerase acidic protein0011
Stromelysin-10112
Tyrosine-protein phosphatase YopH0101
High mobility group protein B10011
Tyrosine-protein phosphatase non-receptor type 10103
Estrogen receptor0001
Cystathionine gamma-lyase0101
5'-AMP-activated protein kinase subunit gamma-10001
5'-AMP-activated protein kinase catalytic subunit alpha-20001
Xanthine dehydrogenase/oxidase0101
5'-AMP-activated protein kinase catalytic subunit alpha-10001
Solute carrier family 22 member 70001
Nicotinate phosphoribosyltransferase0101
Ubiquitin-like domain-containing CTD phosphatase 10101
5'-AMP-activated protein kinase subunit gamma-30001
5'-AMP-activated protein kinase subunit gamma-20001
5'-AMP-activated protein kinase subunit beta-10001
Pyruvate kinase PKM0011
Replicase polyprotein 1ab0101
BRCA11001
P531001
RAD510101
serine/threonine-protein kinase PLK12002
streptokinase A precursor0011
Cocaine esterase0101
Polycomb protein EED0101
Glycoprotein hormones alpha chain1001
Estrogen receptor0011
Replicase polyprotein 1a0202
Tyrosine-protein phosphatase non-receptor type 60101
Tyrosine-protein phosphatase non-receptor type 110101
Polycomb protein SUZ120101
Histone-lysine N-methyltransferase EZH20101
Hypoxia-inducible factor 1-alpha0101
Estrogen receptor beta0011
Endothelial PAS domain-containing protein 10101
Protease 0101
Chain A, ykoF0011
Chain B, ykoF0011
Chain A, ThiT0011
Thiamine transporter ThiT0011
Transketolase0011
Thiamine-binding periplasmic protein0011
Ubiquitin-like modifier activating enzyme 20101
SUMO1 activating enzyme subunit 10101
hexokinase0101
SUMO-conjugating enzyme UBC90101
eukaryotic translation initiation factor 4 gamma 1 isoform 40101
eukaryotic translation initiation factor 4E isoform 10101
Vif0101
Tat0101
bifunctional UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase0101
Alpha-2A adrenergic receptor0101
Alpha-2C adrenergic receptor0101
Histamine H3 receptor0112
Histamine H4 receptor0101
Histamine H4 receptor0112
Histamine H3 receptor0101
Histamine H3 receptor0225
Cholesterol 24-hydroxylase0101
Chain X, Thyroid hormone receptor beta-10011
Chain X, Thyroid hormone receptor beta-10011
Solute carrier organic anion transporter family member 1A40001
Nuclear receptor subfamily 1 group I member 20011
Solute carrier organic anion transporter family member 1A50001
Transthyretin0113
Thyroid hormone receptor alpha0011
Thyroid hormone receptor beta0011
Proliferating cell nuclear antigen0101
Retinoic acid receptor RXR-alpha0022
UDP-glucuronosyltransferase 1A1 0101
Peroxisome proliferator-activated receptor gamma0022
Malate dehydrogenase, mitochondrial0101
Solute carrier organic anion transporter family member 1A20001
Solute carrier organic anion transporter family member 1A30001
Solute carrier organic anion transporter family member 4C10101
Monocarboxylate transporter 80001
Bile acid receptor0101
Solute carrier organic anion transporter family member 1C10001
Solute carrier organic anion transporter family member 1B10001
phospholipase A2 precursor0101
glycogen synthase kinase-3 beta isoform 10011
cysteine protease ATG4B isoform a0101
Vpr1001
Cytochrome c oxidase subunit 20101
Androgen receptor0101
Fatty acid-binding protein, intestinal0101
Aldo-keto reductase family 1 member C30101
Chain A, Trp Rna-binding Attenuation Protein0011
Chain K, Trp Rna-binding Attenuation Protein0011
Chain B, tryptophanyl-tRNA synthetase0011
Chain C, Tryptophanyl-tRNA synthetase II0011
Dihydrofolate reductase0202
Plasma kallikrein0002
Myeloperoxidase0101
Alkaline phosphatase, tissue-nonspecific isozyme0101
Intestinal-type alkaline phosphatase0101
Substance-P receptor0101
Tryptophan 2,3-dioxygenase0102
Carbonic anhydrase0002
SLC16A10 protein0002
Uracil nucleotide/cysteinyl leukotriene receptor0101
Carbonic anhydrase 0002
Tryprostatin B synthase0001
Carbonic anhydrase0002
Carbonic anhydrase0002
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase0011
Carbonic anhydrase 0002
Monocarboxylate transporter 100002
Phospholipase A-2-activating protein0101
Chain A, CHORISMATE MUTASE0101
Chain A, TYROSYL-tRNA SYNTHETASE0011
Tubulin--tyrosine ligase0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]