Page last updated: 2024-09-27

Fusariosis

OPPORTUNISTIC INFECTIONS with the soil fungus FUSARIUM. Typically the infection is limited to the nail plate (ONYCHOMYCOSIS). The infection can however become systemic especially in an IMMUNOCOMPROMISED HOST (e.g., NEUTROPENIA) and results in cutaneous and subcutaneous lesions, fever, KERATITIS, and pulmonary infections.

Synonyms(1)

Synonym
Fusariosis

Research Excerpts

Overview

Excerpt	Reference
"Fusariosis is an emerging infectious complication of immune deficiency, but models to study this infection are lacking."	( Breger, J; Coleman, JJ; Fuchs, BB; Muhammed, M; Mylonakis, E; Wu, MP, 2012)
"Disseminated fusariosis is an uncommon clinical condition in immunocompromised patients."	( Betânia, CA; Macêdo, DP; Neves, RP; Silva, GM; Silveira, AR, 2013)
"Invasive fusariosis is an infection with Fusarium spp."	( Gunasekara, TA; Nagahawatte, A; Ranawaka, RR, 2015)
"Disseminated fusariosis is a life-threatening, invasive, opportunistic infection in immunocompromised patients, especially those with haematological malignancies."	( Bouchnerova, J; Hadrabova, M; Kocmanova, I; Lengerova, M; Mayer, J; Palackova, M; Pavlovsky, Z; Racil, Z; Ricna, D; Volfova, P; Weinbergerova, B, 2016)
"Fusariosis is an opportunistic infection, caused by a filamentous fungus, found on plants and in soil."	( Bonardel, G; Guernou, M; Lussato, D; Queneau, M; Seban, RD, 2017)
"Fusariosis is the second most common mould infection after aspergillosis, and keratitis is the most encountered implantation infection in immunocompetent individuals."	( Al-Hatmi, AMS; Bonifaz, A; Meis, JF; Ranque, S; Sybren de Hoog, G; Verweij, PE, 2018)
"Disseminated fusariosis is a fatal infection in immunocompromised hosts."	( Fujiwara, T; Hasegawa, D; Ishida, T; Kamei, K; Kishimoto, K; Kosaka, Y; Kozaki, A; Muraosa, Y; Nakamura, S; Saito, A; Tahara, T; Tamura, A; Uemura, S; Yamamoto, N, 2018)
"Fusariosis is an opportunistic fungal infection that affects mostly leukemic and hematopoietic stem cell transplant patients."	( Carneiro, MP; Chaves, ALDS; Lopes, FPPL; Machado, LS; Schirmer, MR, 2018)
"Disseminated fusariosis is now the second most frequent lethal fungal infection after aspergillosis especially in neutropenic patients with hematologic malignancy."	( Banfalvi, G, 2018)
"Fusariosis is an infection that is caused by fungi of the Fusarium genus."	( Alexandrino Becker, TC; Costa, MI; Jarros, IC; Kischkel, B; Negri, M; Svidzinski, TIE; Veiga, FF; Vilugron Rodrigues, FA, 2019)
"Fusariosis is a critical infectious complication that can develop in immunocompromised hosts, mainly under conditions of prolonged neutropenia, and is often disseminated and associated with a high mortality rate."	( Fukuhara, N; Harigae, H; Ichikawa, S; Okitsu, Y; Onishi, Y; Onodera, K; Watanabe, S, 2020)
"Fusariosis is the second most common mold infection after aspergillosis, and keratomycosis is the most encountered implantation infection."	( Cai, W; Li, J; Li, X; Lu, S; Ma, J; Shi, M; Xi, L; Zhang, J, 2020)
"Invasive fusariosis is a rare fungal infection in solid organ transplantation."	( Chayakulkeeree, M; Chongtrakool, P; Yamasmith, E, 2020)
"Invasive fusariosis is associated with marked morbidity and mortality in immunocompromised hosts, and clinical outcomes are poor with conventional therapy."	( Badali, H; Cañete-Gibas, C; Fan, H; Garcia, V; Mele, J; Mermella, B; Patterson, H; Sanders, C; Wiederhold, NP, 2021)
"Invasive fusariosis is a serious infection affecting mostly patients with haematologic malignancies and hematopoietic cell transplant recipients."	( Guarana, M; Nouér, SA; Nucci, M, 2021)
"The EQUAL score Fusariosis is a tool that may help clinicians to measure guidelines adherence."	( Guarana, M; Nouér, SA; Nucci, M, 2021)
"Therefore, invasive fusariosis is rare after solid organ transplantation."	( Becker, T; Braun, F; Heß, K; Stropnicky, P, 2022)
"However, CNS fusariosis is rare and often happens due to hematogenous dissemination from other sites."	( Alavi Darazam, I; Hakamifard, A; Jamali, E; Javandoust Gharehbagh, F; Khodavaisy, S; Sharifi, G, 2022)
"Thus, fusariosis is more widespread among the Testudines than previously reported and is not limited to sea environments, findings of particular conservation concern."	( Carranco, AS; Gillingham, MAF; Romo, D; Sommer, S; Torres, ML; Wilhelm, K, 2022)
"Disseminated fusariosis is a rare and fatal infection in immunocompromised patients."	( Hu, J; Li, H; Li, T; Song, Y; Yao, X; Zhong, L, 2022)
"Disseminated fusariosis is a rare and fatal infection in immunocompromised patients."	( Hu, J; Li, H; Li, T; Song, Y; Yao, X; Zhong, L, 2022)
"Fusariosis is a serious threat."	( Aguilar-Zapata, D; Barragán-Reyes, A; Camacho, A; Cendejas, RF; Cornejo-Juárez, P; Guzmán, JMF; Hernández, MLG; Jácome, LEL; Juárez-Hernández, E; Nava-Ruiz, A; Ontañón-Zurita, D; Perales-Martínez, D; Reséndiz-Sánchez, J; Rincón-Zuno, J; Rivera-Martínez, NE, 2023)

Context

Excerpt	Reference
"Fusariosis has been reported sporadically in fish and other aquatic organisms, but identification has often been limited to the genus level based solely on morphologic features."	( Berliner, AL; Camus, AC; Clauss, TM; Knowles, S; Marancik, DP; O'Donnell, K; Salter, CE; Sutton, DA, 2012)
"Disseminated fusariosis has emerged as a significant, usually fatal infection in immunocompromised hosts despite antifungal treatment."	( Brasil, RA; de Angelis, DA; de Matos Castro e Silva, D; de Souza Carvalho Melhem, M; dos Anjos Martins, M; Pereira, GH; Szeszs, MW, 2013)
"Disseminated fusariosis has a high mortality and is predominantly observed in patients with leukemia."	( Al-Hatmi, AS; Cilo, BD; Curfs-Breuker, I; Ener, B; Ersal, T; Meis, JF; Özkalemkaş, F; van Diepeningen, AD, 2015)
"Fusariosis have been increasing in Colombia in recent years, but its epidemiology is poorly known."	( Amézquita, A; Cano, LE; Cano-Lira, JF; Cárdenas, M; Celis, A; De Bedout, C; de García, MC; Espinel-Ingroff, A; García, AM; Guarro, J; Guevara-Suarez, M; Motta, A; Restrepo, S; Sopo, L, 2016)
"Invasive fusariosis has a high mortality and is predominantly observed in patients with leukemia."	( Dallé Rosa, P; Goldani, LZ; Meneghello Fuentefria, A; Ramirez-Castrillon, M; Valente, P; Van Diepeningen, AD, 2018)
"Fusariosis has presented a significant increase in their incidence in the last years."	( da Rosa Monte Machado, G; de Andrade, SF; Henning Vainstein, M; José Alves, R; Lettieri Teixeira, M; Lopes, W; Meneghello Fuentefria, A; Neiva Lavorato, S, 2022)

Treatment

Excerpt	Reference
"The difficulty in treating cases of fusariosis in the human medical clinic exemplifies this situation, because when Fusarium spp."	( de Andrade, SF; de Chaves, MA; Fernanda Andrzejewski Kaminski, T; Ferreira do Amaral, T; Flavio Souza de Oliveira, L; Fuentefria, AM; Monteiro da Silva Rodrigues Coutinho, N; Teixeira, ML, 2020)

Research

Studies (435)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	1 (0.23)	23.3326
1990's	0 (0.00)	12.5806
2000's	1 (0.23)	18.1394
2010's	349 (80.23)	28.8240
2020's	84 (19.31)	9.53

Drug	Relationship Strength	Studies	Trials
adenine	low	2	0
ammonium hydroxide	low	1	0
carbamates	low	2	0
salicylic acid	low	2	0
formaldehyde	low	2	0
indoleacetic acid	low	1	0
methanol	low	1	0
melatonin	low	1	0
nickel	low	1	0
phenol	low	1	0
phosphorylcholine	low	2	0
alexidine	low	1	0
ciclopirox	low	1	0
ciprofloxacin	low	1	0
clioquinol	low	1	0
fluconazole	low	4	0
gentamicin	low	1	0
miltefosine	low	2	0
ketoconazole	low	1	0
miconazole	low	1	0
mitoxantrone	low	2	0
pyrimethamine	low	1	0
sulfadiazine	low	1	0
prednisolone	low	2	0
benzimidazole	low	2	0
prednisolone acetate	low	1	0
biguanides	low	3	0
sucrose	low	1	0
galactose	low	9	0
cytarabine	low	2	0
valine	low	1	0
arginine	low	1	0
chloroacetamide	low	1	0
methyleugenol	low	1	0
pyrroles	low	1	0
isoxazoles	low	1	0
azacitidine	low	1	0
fusarium	medium	392	4
alpha-aminopyridine	low	1	0
c.i. 42510	low	1	0
zinc oxide	low	1	0
vantocil	low	2	0
silver	low	2	0
cadmium	low	1	0
gold	low	1	0
trolamine salicylate	low	2	0
carbendazim	low	2	0
fluorides	low	1	0
etoposide	low	1	0
deoxynivalenol	low	6	0
idarubicin	low	1	0
loceryl	low	1	0
itraconazole	low	13	0
adenosine	low	1	0
trazodone hydrochloride	low	11	0
cephalosporin c	low	1	0
propamidine isethionate	low	1	0
triazoles	medium	39	1
fluorodeoxyglucose f18	low	2	0
magnolol	low	1	0
honokiol	low	1	0
clarithromycin	low	1	0
n-methyladenosine	low	1	0
cobalt	low	1	0
beauvericin	low	1	0
clofarabine	low	1	0
1,3,4-thiadiazole	low	1	0
cucurbitaceae	low	1	0
levofloxacin	low	1	0
anidulafungin	low	2	0
lignin	low	2	0
deoxycholic acid	low	3	0
trimethoprim, sulfamethoxazole drug combination	low	1	0
povidone-iodine	low	1	0
epiglucan	low	6	0
laminaran	low	1	0
cellulase	low	1	0
lignans	low	1	0
ergosterol	low	1	0
mycophenolic acid	low	1	0
posaconazole	low	11	0
l 743,872	low	5	0
micafungin	low	2	0
efinaconazole	low	3	0
riboflavin	low	3	0
bromochloroacetic acid	low	1	0
stilbenes	low	1	0
sesquiterpenes	low	2	0
terbinafine	low	12	0
fumonisin b1	low	5	0
nnd 502	low	3	0
laccase	low	1	0
galactomannan	low	9	0
amphotericin b	low	58	0
zearalenone	low	3	0
phenylephrine hydrochloride	low	1	0
3-acetyldeoxynivalenol	low	1	0
boron	low	1	0
cefepime	low	1	0
cefotaxime	low	1	0
c.i. fluorescent brightening agent 28	low	1	0
coomassie brilliant blue	low	1	0
isavuconazole	low	1	0
chlorhexidine	low	1	0
mocetinostat	low	2	0
15-acetyldeoxynivalenol	low	1	0
gentamicin b	low	1	0
cellulose	low	1	0
chlorophyll a	low	2	0
3-(3-(4-((pyridin-2-yloxy)methyl)benzyl)isoxazol-5-yl)pyridin-2-amine	low	1	0
amphotericin b, deoxycholate drug combination	low	3	0
pci 32765	low	2	0
mannans	low	9	0
piperidines	low	2	0
fusariumin	low	2	0
ascorbic acid	low	1	0
salicylates	low	1	0
warfarin	low	2	0
tigecycline	low	1	0
3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid	low	1	0
t-2 toxin	low	2	0
acyclovir	low	1	0
valacyclovir	low	1	0
eye	low	1	0
metallothionein	low	1	0

Protein Targets (1,276)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain E, Purine nucleoside phosphorylase	0	1	0	1
Chain A, HADH2 protein	9	0	0	9
Chain B, HADH2 protein	9	0	0	9
Chain A, ATP-DEPENDENT DNA HELICASE Q1	5	0	0	5
Chain A, Ferritin light chain	8	0	0	8
Thymidine kinase	0	1	0	1
thioredoxin reductase	12	0	0	12
phosphopantetheinyl transferase	8	0	0	8
GLS protein	4	0	0	4
TDP1 protein	32	0	0	32
Smad3	12	0	0	12
thyroid stimulating hormone receptor	6	0	0	6
EWS/FLI fusion protein	16	0	0	16
arylsulfatase A	6	0	0	6
euchromatic histone-lysine N-methyltransferase 2	19	0	0	19
activating transcription factor 6	11	0	0	11
Histone H2A.x	13	0	0	13
Bloom syndrome protein isoform 1	7	0	0	7
hemoglobin subunit beta	2	0	0	2
atrial natriuretic peptide receptor 1 precursor	2	0	0	2
ubiquitin carboxyl-terminal hydrolase 2 isoform a	4	0	0	4
lamin isoform A-delta10	21	0	0	21
Solute carrier family 22 member 1	0	4	0	5
ATP-binding cassette sub-family C member 3	0	18	0	18
Multidrug resistance-associated protein 4	0	18	0	18
Solute carrier family 22 member 6	0	2	0	3
Bile salt export pump	0	4	0	4
Bile salt export pump	0	23	0	23
Purine nucleoside phosphorylase	0	2	0	2
Thymidine kinase, cytosolic	0	1	0	2
POU domain, class 2, transcription factor 2	0	0	0	1
Cytochrome P450 2C9	0	14	1	16
Cytochrome P450 2J2	0	2	0	2
Disintegrin and metalloproteinase domain-containing protein 17	2	0	0	2
Purine nucleoside phosphorylase	0	0	1	1
Solute carrier family 22 member 6	0	2	0	3
Thymidine kinase	0	1	0	1
Solute carrier family 22 member 8	0	2	0	4
Canalicular multispecific organic anion transporter 1	0	17	0	18
Thymidine kinase	0	2	0	2
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	10	0	0	10
Chain A, MTA/SAH nucleosidase	0	1	0	1
Chain A, Ribosome-inactivating protein alpha-trichosanthin	0	0	1	1
Chain A, Ricin A chain	0	0	1	1
Chain A, Ribosome-inactivating protein 3	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
RAR-related orphan receptor gamma	25	0	0	25
AR protein	32	0	0	32
nuclear receptor subfamily 1, group I, member 3	23	0	0	23
cytochrome P450 family 3 subfamily A polypeptide 4	27	0	0	27
glucocorticoid receptor [Homo sapiens]	29	0	0	29
estrogen-related nuclear receptor alpha	29	0	0	29
pregnane X nuclear receptor	22	0	0	22
estrogen nuclear receptor alpha	37	0	0	37
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	19	0	0	19
nuclear factor erythroid 2-related factor 2 isoform 2	14	0	0	14
heat shock protein beta-1	9	0	0	9
importin subunit beta-1 isoform 1	5	0	0	5
snurportin-1	5	0	0	5
tumor susceptibility gene 101 protein	2	0	0	2
GTP-binding nuclear protein Ran isoform 1	3	0	0	3
Voltage-dependent calcium channel gamma-2 subunit	18	0	0	18
Cyclin-dependent kinase 1	0	2	1	3
Heat shock protein HSP 90-beta	0	1	0	1
Glutamate receptor 2	19	1	0	20
Xanthine dehydrogenase/oxidase	0	1	0	1
TAR DNA-binding protein 43	9	1	0	10
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
Leucine-rich repeat serine/threonine-protein kinase 2	0	2	0	2
ATPase family AAA domain-containing protein 5	14	0	0	14
Ataxin-2	18	0	0	18
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain B, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, tRNA (guanine-N(1)-)-methyltransferase	0	0	1	1
Chain A, Uncharacterized protein MJ0883	0	0	1	1
signal transducer and activator of transcription 6, interleukin-4 induced	1	0	0	1
regulator of G-protein signaling 4	6	0	0	6
retinoid X nuclear receptor alpha	22	0	0	22
NPYLR7B	0	0	4	4
IDH1	13	0	0	13
glycogen synthase kinase-3 beta isoform 1	0	0	2	2
mitogen-activated protein kinase 1	10	0	0	10
flap endonuclease 1	8	0	0	8
nuclear receptor ROR-gamma isoform 1	10	0	0	10
peripheral myelin protein 22	15	0	0	15
survival motor neuron protein isoform d	9	0	0	9
high affinity choline transporter 1 isoform a	0	3	0	3
Sodium/nucleoside cotransporter 1	0	2	0	2
Calcium dependent protein kinase	0	1	0	1
Mitogen-activated protein kinase kinase kinase 7	0	0	1	1
Sodium/nucleoside cotransporter 2	0	2	0	2
Rap guanine nucleotide exchange factor 3	2	0	0	2
Epidermal growth factor receptor	0	5	2	7
Phosphoglycerate kinase 1	0	1	0	1
Adenosine deaminase	0	0	0	1
Avidin	0	0	1	1
Adenosine deaminase	0	0	0	1
Glyceraldehyde-3-phosphate dehydrogenase	0	2	0	2
Receptor tyrosine-protein kinase erbB-2	0	4	1	5
Insulin receptor	0	0	1	2
Phosphoglycerate kinase 2	0	1	0	1
Heat shock protein HSP 90-alpha	0	2	3	5
Platelet-derived growth factor receptor beta	0	1	1	3
Adenosine receptor A3	0	6	2	9
Heat shock 70 kDa protein 1A	0	1	0	1
Heat shock cognate 71 kDa protein	0	0	1	1
Fibroblast growth factor receptor 1	0	0	1	2
Inosine-5'-monophosphate dehydrogenase 2	0	3	1	4
Endoplasmin	0	2	2	4
Inosine-5'-monophosphate dehydrogenase 1	0	3	0	3
Fibroblast growth factor receptor 2	0	0	0	1
Fibroblast growth factor receptor 4	0	0	0	1
Fibroblast growth factor receptor 3	0	0	0	1
Streptavidin	0	0	1	1
Adenosylhomocysteinase	0	0	0	1
Adenosine receptor A1	0	2	1	3
Adenosine receptor A3	0	2	0	2
Adenosine receptor A2a	0	4	2	8
Adenosine receptor A2b	0	0	1	3
Adenosine receptor A2b	0	1	1	2
Adenylate kinase 2, mitochondrial	0	1	0	1
Adenosine receptor A1	0	6	2	10
Adenosine receptor A2a	0	2	1	3
Adenylate kinase isoenzyme 1	0	1	0	1
Phosphatidylinositol 4-kinase alpha	0	3	0	4
Adenosine receptor A1	0	0	1	1
Adenosine kinase	0	0	1	2
Adenosine deaminase	0	0	0	1
Equilibrative nucleoside transporter 2	0	2	0	2
Phosphatidylinositol 4-kinase type 2-beta	0	3	0	4
Histone-lysine N-methyltransferase, H3 lysine-79 specific	0	1	0	1
Equilibrative nucleoside transporter 1	0	2	0	2
Phosphatidylinositol 4-kinase type 2-alpha	0	3	0	4
Solute carrier family 28 member 3	0	2	0	2
Adenosine kinase	0	1	0	2
Phosphatidylinositol 4-kinase beta	0	3	0	4
5-methylthioadenosine/S-adenosylhomocysteine deaminase	0	0	0	1
Adenosine transporter 1	0	0	0	1
retinoic acid nuclear receptor alpha variant 1	27	0	0	27
thyroid stimulating hormone receptor	13	0	0	13
thyroid hormone receptor beta isoform 2	24	0	0	24
Botulinum neurotoxin type A	0	2	0	2
Neutrophil cytosol factor 1	0	1	0	1
Nitric oxide synthase, endothelial	0	1	0	1
Nitric oxide synthase, brain	0	1	0	2
Nitric oxide synthase, brain	0	1	0	2
Nitric oxide synthase, inducible	0	1	1	4
Kappa-type opioid receptor	0	0	1	3
Mu-type opioid receptor	0	0	1	1
Tyrosine-protein kinase	0	0	1	1
Chain A, Cruzipain	6	0	0	6
interleukin 8	6	0	0	6
farnesoid X nuclear receptor	17	0	0	17
peroxisome proliferator-activated receptor delta	14	0	0	14
vitamin D (1,25- dihydroxyvitamin D3) receptor	13	0	0	13
tumor necrosis factor	2	0	0	2
vitamin D3 receptor isoform VDRA	5	0	0	5
nuclear factor erythroid 2-related factor 2 isoform 1	27	0	0	27
Cytochrome P450 1A2	0	7	0	7
Cytochrome P450 3A4	0	15	2	20
Cytochrome P450 2D6	0	10	0	10
Cytochrome P450 2C19	0	8	0	9
Nuclear receptor ROR-gamma	8	0	0	8
Potassium voltage-gated channel subfamily H member 2	0	14	0	15
Aurora kinase B	0	2	1	3
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	5	0	6
Replicase polyprotein 1ab	0	1	0	1
Cytochrome P450 2C8	0	3	0	4
Cytochrome P450 2B6	0	4	0	5
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
NFKB1 protein, partial	3	0	0	3
alpha-galactosidase	2	0	0	2
cytochrome P450 2C19 precursor	3	0	0	3
chromobox protein homolog 1	14	0	0	14
DNA polymerase iota isoform a (long)	10	0	0	10
muscarinic acetylcholine receptor M1	4	0	0	4
lethal factor (plasmid)	6	0	0	6
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, inducible	0	1	0	2
Cationic amino acid transporter 3	0	1	0	1
ATP-dependent phosphofructokinase	8	0	0	8
Chain A, Hyaluronidase, phage associated	0	1	0	1
acetylcholinesterase	7	0	0	7
GLI family zinc finger 3	25	0	0	25
thioredoxin glutathione reductase	6	0	0	6
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
geminin	26	0	0	26
Polyphenol oxidase 2	0	2	0	4
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	1	0	2
Urease	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	1	0	1
Alpha-2B adrenergic receptor	0	4	1	5
Spike glycoprotein	17	0	0	17
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
Chain A, Beta-lactamase	4	0	0	4
glp-1 receptor, partial	14	0	0	14
pregnane X receptor	4	0	0	4
ATAD5 protein, partial	9	0	0	9
Fumarate hydratase	13	0	0	13
PPM1D protein	10	0	0	10
Thrombopoietin	2	0	0	2
aldehyde dehydrogenase 1 family, member A1	15	0	0	15
estrogen receptor 2 (ER beta)	14	0	0	14
progesterone receptor	18	0	0	18
polyprotein	13	0	0	13
67.9K protein	12	0	0	12
Parkin	4	0	0	4
peroxisome proliferator activated receptor gamma	20	0	0	20
aryl hydrocarbon receptor	15	0	0	15
peripheral myelin protein 22 isoform 1	3	0	0	3
cellular tumor antigen p53 isoform a	5	0	0	5
huntingtin isoform 2	6	0	0	6
ras-related protein Rab-9A	4	0	0	4
serine/threonine-protein kinase mTOR isoform 1	4	0	0	4
urokinase-type plasminogen activator precursor	8	0	0	8
plasminogen precursor	8	0	0	8
urokinase plasminogen activator surface receptor precursor	8	0	0	8
histone acetyltransferase KAT2A isoform 1	9	0	0	9
Interferon beta	23	0	0	23
Cellular tumor antigen p53	25	0	0	25
Integrin beta-3	5	0	0	5
Integrin alpha-IIb	5	0	0	5
DNA (cytosine-5)-methyltransferase 1	0	1	0	1
D(1A) dopamine receptor	3	0	0	3
Multidrug and toxin extrusion protein 1	0	5	0	5
Histone-lysine N-methyltransferase EHMT2	0	1	0	1
Chain A, GTPase KRas, isoform 2B	0	0	1	1
Chain A, GTPase KRas, isoform 2B	0	0	1	1
Membrane primary amine oxidase	0	1	0	1
Cytochrome P450 2B1	0	1	0	2
Cytochrome P450 1A1	0	1	0	2
GTPase KRas	0	0	1	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	2
Glutaminyl-peptide cyclotransferase	0	1	0	1
Lanosterol 14-alpha demethylase	0	5	2	7
Membrane primary amine oxidase	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
nuclear receptor subfamily 1, group I, member 2	4	0	0	4
Luciferase	7	0	0	7
caspase 7, apoptosis-related cysteine protease	7	0	0	7
caspase-3	7	0	0	7
v-jun sarcoma virus 17 oncogene homolog (avian)	13	0	0	13
thyroid hormone receptor beta isoform a	9	0	0	9
histone deacetylase 9 isoform 3	3	0	0	3
Methionine aminopeptidase	0	1	0	1
Fatty-acid amide hydrolase 1	0	2	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	2
Beta-lactamase	0	1	0	2
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase type 2	0	0	0	2
Metallo-beta-lactamase VIM-11	0	0	0	2
Metallo-beta-lactamase VIM-2	0	0	0	2
Metallo-beta-lactamase VIM-19	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase	0	0	0	2
Beta-lactamase	0	1	0	2
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 5	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase SHV-1	0	0	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	2
Solute carrier family 15 member 1	0	4	0	5
Beta-lactamase TEM	0	1	0	2
Beta-lactamase	0	0	0	1
B2 metallo-beta-lactamase	0	0	0	2
Solute carrier family 15 member 2	0	2	0	2
Metallo-beta-lactamase VIM-13	0	0	0	2
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase VIM-2	0	0	0	2
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase	0	0	0	2
Solute carrier family 15 member 2	0	3	0	3
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-b-lactamase	0	0	0	2
BlaVIM-1	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase class B VIM-2	0	0	0	2
Beta-lactamase VIM-1	0	0	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Albumin	0	1	2	3
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase Toho-1	0	0	0	1
Solute carrier family 22 member 7	0	1	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	1
Histamine H3 receptor	0	0	0	1
Solute carrier family 22 member 11	0	1	0	1
Solute carrier family 22 member 8	0	1	0	1
Solute carrier family 22 member 7	0	1	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	7	0	0	7
Chain A, BCL-2-RELATED PROTEIN A1	0	0	2	2
acid sphingomyelinase	3	0	0	3
PAX8	0	0	0	1
15-lipoxygenase, partial	5	0	0	5
hypoxia-inducible factor 1 alpha subunit	9	0	0	9
SMAD family member 2	10	0	0	10
USP1 protein, partial	10	0	0	10
SMAD family member 3	10	0	0	10
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	5	0	0	5
PINK1	1	0	0	1
G	14	0	0	14
cytochrome P450 2D6	16	0	0	16
glucocerebrosidase	1	0	0	1
heat shock protein 90	0	0	1	1
calcineurin A1, putative	0	0	1	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	10	0	0	10
cytochrome P450 2D6 isoform 1	5	0	0	5
hepatocyte nuclear factor 4-alpha isoform 2	0	1	0	1
cytochrome P450 2C9 precursor	3	0	0	3
perilipin-5	0	1	0	1
perilipin-1	0	1	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	9	0	0	9
transcriptional regulator ERG isoform 3	5	0	0	5
ubiquitin-conjugating enzyme E2 N	0	1	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	3	0	0	3
protein AF-9 isoform a	0	0	0	3
melanocortin receptor 4	0	1	0	1
CAAX prenyl protease	0	0	0	1
bcl-2-related protein A1	0	1	0	1
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
DNA polymerase kappa isoform 1	4	0	0	4
cytochrome P450 3A4 isoform 1	10	0	0	10
glycogen synthase kinase-3 alpha	0	0	0	1
hexokinase HKDC1	0	1	0	1
DNA repair protein RAD52 homolog isoform a	0	0	0	3
bcl-2-like protein 11 isoform 1	0	0	2	2
Gamma-aminobutyric acid receptor subunit pi	10	1	0	11
Synaptojanin-2	0	1	0	1
Solute carrier family 22 member 2	0	2	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15B	5	0	0	5
Synaptojanin-1	0	1	0	1
Solute carrier family 22 member 3	0	3	0	3
Glutathione reductase, mitochondrial	0	2	0	4
HLA class I histocompatibility antigen, B alpha chain	14	0	0	14
72 kDa type IV collagenase	0	1	0	1
Matrix metalloproteinase-9	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	10	1	0	11
Gamma-aminobutyric acid receptor subunit delta	10	1	0	11
Gamma-aminobutyric acid receptor subunit gamma-2	10	1	0	11
Gamma-aminobutyric acid receptor subunit alpha-5	10	1	0	11
Gamma-aminobutyric acid receptor subunit alpha-3	10	1	0	11
Gamma-aminobutyric acid receptor subunit gamma-1	10	1	0	11
Gamma-aminobutyric acid receptor subunit alpha-2	10	1	0	11
Gamma-aminobutyric acid receptor subunit alpha-4	10	1	0	11
Gamma-aminobutyric acid receptor subunit gamma-3	10	1	0	11
Trypanothione reductase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	10	1	0	11
Alpha-synuclein	5	0	0	5
Histamine H2 receptor	6	0	0	6
Gamma-aminobutyric acid receptor subunit alpha-1	10	1	0	11
Gamma-aminobutyric acid receptor subunit beta-3	10	1	0	11
Gamma-aminobutyric acid receptor subunit beta-2	10	1	0	11
Peroxisomal N(1)-acetyl-spermine/spermidine oxidase	0	1	0	1
Multidrug and toxin extrusion protein 2	0	2	0	2
Rap guanine nucleotide exchange factor 4	4	0	0	4
GABA theta subunit	10	1	0	11
Inositol hexakisphosphate kinase 1	14	0	0	14
Gamma-aminobutyric acid receptor subunit epsilon	10	1	0	11
Spermine oxidase	0	1	0	1
cytochrome P450 2C9, partial	14	0	0	14
Alcohol dehydrogenase E chain	0	1	0	1
Alcohol dehydrogenase S chain	0	1	0	1
Isocitrate dehydrogenase [NADP] cytoplasmic	0	1	0	1
Lysine-specific demethylase 4B	0	1	0	1
Hypoxia-inducible factor 1-alpha	0	1	0	1
Deoxyhypusine hydroxylase	0	1	0	1
Chain A, 2-oxoglutarate Oxygenase	12	0	0	12
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	9	0	0	9
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	1	0	2
DNA gyrase subunit A	0	1	0	3
DNA gyrase subunit B	0	1	0	3
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	2
DNA topoisomerase 4 subunit A	0	1	0	2
DNA topoisomerase 2-alpha	0	3	2	14
DNA gyrase subunit A	0	1	0	2
Multidrug resistance protein MdtK	0	0	1	1
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	2	0	2
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	0	0	1
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	1
Integrase	0	3	0	3
streptokinase A precursor	0	0	3	3
ATP-dependent translocase ABCB1	0	9	0	11
Solute carrier organic anion transporter family member 1B3	0	5	0	5
Solute carrier organic anion transporter family member 1B1	0	1	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	7	0	0	7
mu opioid receptor, partial	0	0	1	1
90-kda heat shock protein beta HSP90 beta, partial	0	2	0	2
Microtubule-associated protein tau	4	0	0	4
nonstructural protein 1	5	0	0	5
bromodomain adjacent to zinc finger domain 2B	2	0	0	2
LAP4	0	0	1	1
MEP2	0	0	1	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
delta-type opioid receptor	0	1	1	2
kappa-type opioid receptor isoform 1	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	5	0	0	5
heat shock protein HSP 90-alpha isoform 2	0	2	0	5
DNA dC->dU-editing enzyme APOBEC-3F isoform a	1	0	0	1
Histone deacetylase 3	0	4	0	4
Carbonic anhydrase 12	0	2	0	3
Carbonic anhydrase 1	0	6	0	7
Carbonic anhydrase 2	0	7	1	9
Amyloid-beta precursor protein	2	2	0	4
Carbonic anhydrase 3	0	2	0	3
Spike glycoprotein	0	1	1	2
Alpha-1B adrenergic receptor	0	3	1	4
Catechol O-methyltransferase	0	1	0	1
Carbonic anhydrase 4	0	3	0	4
Carbonic anhydrase 6	0	4	0	5
Alpha-1D adrenergic receptor	0	1	1	2
Carbonic anhydrase 5A, mitochondrial	0	2	0	3
Alpha-1A adrenergic receptor	0	4	1	5
Carbonic anhydrase 7	0	2	0	3
Histone deacetylase 4	0	3	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Histone deacetylase 1	0	4	0	4
Carbonic anhydrase 9	0	3	1	5
Beta-galactosidase	0	0	1	1
Histone deacetylase 7	0	3	0	3
Histone deacetylase 2	0	4	0	4
Polyamine deacetylase HDAC10	0	2	0	2
Histone deacetylase 11	0	3	0	3
Carbonic anhydrase 15	0	4	0	4
Histone deacetylase 8	0	3	0	3
Carbonic anhydrase 13	0	2	0	3
Histone deacetylase 6	0	3	0	3
Histone deacetylase 9	0	2	0	2
Carbonic anhydrase 14	0	2	0	3
Histone deacetylase 5	0	3	0	3
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	2
heat shock protein 90, putative	0	0	0	3
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	2	0	2
endonuclease IV	2	0	0	2
LMP1 [Human herpesvirus 4]	0	0	0	3
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	2	0	2
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	4	0	0	4
transactivating tegument protein VP16 [Human herpesvirus 1]	0	2	0	2
nuclear receptor coactivator 3 isoform a	0	2	0	2
Thymidine kinase 2, mitochondrial	0	1	0	1
Thymidine kinase	0	1	0	1
Thymidylate synthase	0	0	0	1
Thymidine kinase	0	1	0	1
Deoxycytidine kinase	0	0	1	2
Probable deoxycytidylate deaminase	0	0	0	1
Cytidine deaminase	0	1	0	2
E3 ubiquitin-protein ligase Mdm2	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	1
Deoxynucleoside kinase	0	1	0	1
Chain A, STEROID DELTA-ISOMERASE	0	0	1	1
Steroid Delta-isomerase	0	0	1	1
Vitamin D3 receptor	0	1	1	2
Ileal sodium/bile acid cotransporter	0	1	0	1
G-protein coupled bile acid receptor 1	0	2	1	3
Bile acid receptor	0	0	1	1
Prothrombin	0	0	0	1
Regulatory protein E2	0	0	1	1
ATP-dependent translocase ABCB1	0	6	0	6
DNA topoisomerase 1	0	1	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15	0	3	0	3
DNA topoisomerase 2	0	0	0	2
ATP-dependent translocase ABCB1	0	6	0	6
UDP-glucuronosyltransferase 1A1	0	1	0	3
Serum paraoxonase/arylesterase 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	2	0	3
Caspase-3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	2	0	3
Glutamate receptor ionotropic, NMDA 2B	0	2	0	3
Glutamate receptor ionotropic, NMDA 2C	0	2	0	4
DNA topoisomerase 2-alpha	0	0	0	1
DNA topoisomerase 2-beta	0	1	2	10
Glutamate receptor ionotropic, NMDA 2D	0	2	0	3
Tubulin beta-2B chain	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	2	0	3
Glutamate receptor ionotropic, NMDA 3A	0	2	0	3
apical membrane antigen 1, AMA1	2	0	0	2
unnamed protein product	0	1	0	1
Chymotrypsinogen A	0	3	0	3
Beta-lactamase	0	3	0	3
Steroid 17-alpha-hydroxylase/17,20 lyase	0	5	0	5
Heme oxygenase 1	0	2	0	2
Lanosterol 14-alpha demethylase	0	1	3	4
Aromatase	0	6	0	6
Cytochrome P450 11B1, mitochondrial	0	3	0	3
Cytochrome P450 11B2, mitochondrial	0	3	0	3
Heme oxygenase 2	0	2	0	2
Malate dehydrogenase, cytoplasmic	0	3	0	3
Cytochrome P450 144	0	0	4	4
Steroid C26-monooxygenase	0	0	4	4
Steroid C26-monooxygenase	0	0	4	4
Mycocyclosin synthase	0	0	2	2
Lanosterol 14-alpha demethylase	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	2	2
Sterol 14-alpha demethylase	0	0	3	3
Sterol 14-alpha demethylase	0	2	2	4
14-alpha sterol demethylase	0	0	3	3
likely tRNA 2'-phosphotransferase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Beta-galactosidase	0	1	0	1
Lipopolysaccharide heptosyltransferase 1	0	1	0	1
PA-I galactophilic lectin	0	0	1	1
Jacalin	0	0	1	1
Neuraminidase	0	1	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	2	0	0	2
TPA: protein transporter TIM10	0	2	0	2
lysosomal alpha-glucosidase preproprotein	4	0	0	4
DNA polymerase beta	4	0	0	4
Vpr	6	0	0	6
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	3	3
Gamma-aminobutyric acid receptor subunit beta-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	3	3
Retinoic acid receptor RXR-alpha	0	0	1	2
Cannabinoid receptor 1	0	4	2	6
Gamma-aminobutyric acid receptor subunit beta-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	1	1
Cannabinoid receptor 2	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-2	0	0	3	3
Prostaglandin G/H synthase 2	0	1	0	1
Angiotensin-converting enzyme 2	0	0	1	1
Platelet glycoprotein VI	0	1	1	2
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	0	0	2	2
DNA polymerase III, partial	2	0	0	2
hexokinase-4 isoform 1	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	2	0	0	2
D(1A) dopamine receptor	1	0	0	1
glucokinase regulatory protein	1	0	0	1
eyes absent homolog 2 isoform a	1	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	3	0	0	3
DNA polymerase eta isoform 1	3	0	0	3
M-phase phosphoprotein 8	3	0	0	3
muscleblind-like protein 1 isoform 1	3	0	0	3
Glutamate receptor 1	1	1	0	2
Glutamate receptor 3	1	1	0	2
Glutamate receptor 4	1	1	0	2
Inositol monophosphatase 1	4	0	0	4
Single-stranded DNA cytosine deaminase	2	0	0	2
Peptide deformylase 1A, chloroplastic/mitochondrial	0	1	0	1
Peptide deformylase	0	1	0	1
GALC protein	3	0	0	3
Estrogen receptor beta	0	1	0	2
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	0	1	0	1
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	0	2	0	2
Cytochrome P450 26A1	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
3',5'-cyclic-AMP phosphodiesterase	0	1	0	1
Camphor 5-monooxygenase	0	0	0	1
Phospholipase A2, major isoenzyme	0	1	0	1
Epoxide hydrolase 1	0	0	0	2
Aldo-keto reductase family 1 member B1	0	8	0	8
Muscarinic acetylcholine receptor M2	0	6	0	6
Cytochrome P450 2C11	0	2	0	2
Steroid 21-hydroxylase	0	1	0	1
Alpha-2A adrenergic receptor	0	6	0	6
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Cholesterol side-chain cleavage enzyme, mitochondrial	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	2	0	2
Cytochrome P450 2A2	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Translocator protein	0	1	0	1
Cytochrome P450 7A1	0	1	0	1
Estrogen receptor	0	1	0	2
Substance-K receptor	0	4	0	4
Sodium-dependent noradrenaline transporter	0	8	1	9
Thromboxane-A synthase	0	2	0	2
Histamine H2 receptor	0	4	0	4
Gonadotropin-releasing hormone receptor	0	1	1	2
Sodium-dependent serotonin transporter	0	4	0	4
Type-1 angiotensin II receptor	0	1	0	1
Delta-type opioid receptor	0	4	0	4
Cytochrome P450 4F2	0	1	0	1
Sodium-dependent dopamine transporter	0	4	0	4
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	2	0	2
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	1
Cytochrome P450 7A1	0	1	0	1
Lanosterol 14-alpha demethylase	0	2	0	2
Replicase polyprotein 1ab	0	1	0	1
CAAX prenyl protease 2 isoform 2	0	0	0	1
Tubulin beta-4A chain	0	1	0	1
Tubulin beta chain	0	1	0	1
Tubulin alpha-3C chain	0	1	0	1
Tubulin alpha-1B chain	0	1	0	1
Tubulin alpha-4A chain	0	1	0	1
Tubulin beta-4B chain	0	1	0	1
DNA primase	0	1	0	1
Tubulin beta-3 chain	0	1	0	1
Tubulin beta-2A chain	0	1	0	1
Tubulin beta-8 chain	0	1	0	1
Tubulin alpha-3E chain	0	1	0	1
Tubulin alpha-1A chain	0	1	0	1
Tubulin alpha-1C chain	0	1	0	1
Tubulin beta-6 chain	0	1	0	1
Tubulin beta-2B chain	0	1	0	1
Tubulin beta-1 chain	0	1	0	1
Chain A, Retinoic acid receptor RXR-alpha	0	0	1	1
Chain A, Peroxisome proliferator-activated receptor gamma	0	0	1	1
neuropeptide S receptor isoform A	2	0	0	2
Aldehyde dehydrogenase, mitochondrial	0	0	1	1
ClpP	1	0	0	1
Cytochrome P450 1A1	0	1	0	1
Cytochrome P450 1A2	0	2	0	2
Myeloperoxidase	0	1	0	1
Cholinesterase	0	1	0	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	2	1	3
Acetylcholinesterase	0	3	0	3
Metabotropic glutamate receptor 1	0	1	0	1
Acetylcholinesterase	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Nociceptin receptor	0	1	0	1
Melatonin receptor type 1A	0	2	1	3
Melatonin receptor type 1C	0	0	1	1
Melatonin receptor type 1A	0	1	1	2
Melatonin receptor type 1B	0	2	1	3
Melatonin receptor type 1C	0	1	1	2
Melatonin receptor type 1B	0	1	1	2
Nuclear factor erythroid 2-related factor 2	0	0	0	1
Cytochrome P450 1B1	0	1	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	1	0	1
Carboxylic ester hydrolase	0	1	0	1
Histamine H3 receptor	0	1	0	1
Chain E, Fibrin beta chain	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	2	0	0	2
T cell receptor, partial	1	0	0	1
luteinizing hormone receptor	1	0	0	1
integrase, partial	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	2	0	0	2
lens epithelium-derived growth factor p75	0	1	0	1
Caspase 6, apoptosis-related cysteine peptidase	0	0	0	1
TSHR protein	1	0	0	1
Apoptotic peptidase activating factor 1	0	1	0	1
hypothetical protein, conserved	2	0	0	2
isocitrate dehydrogenase 1, partial	1	0	0	1
luciferase	1	0	0	1
serine-protein kinase ATM isoform a	1	0	0	1
neutrophil cytosol factor 1	0	1	0	1
caspase-9 isoform alpha precursor	0	1	0	1
pyruvate kinase PKM isoform a	1	0	0	1
caspase-3 isoform a preproprotein	0	1	0	1
replicative DNA helicase	0	0	0	1
recombinase A	0	0	1	1
POsterior Segregation	0	0	1	1
Glutathione reductase	0	1	0	1
Glycoprotein hormones alpha chain	2	0	0	2
Dihydrolipoyl dehydrogenase, mitochondrial	0	1	0	2
Microtubule-associated protein tau	0	1	1	2
Amine oxidase [flavin-containing] A	0	1	0	1
Cruzipain	0	1	0	1
Guanine nucleotide-binding protein G	2	0	0	2
Thioredoxin reductase 1, cytoplasmic	0	1	0	2
Dihydrolipoyl dehydrogenase	0	1	0	2
Zinc finger protein mex-5	0	0	1	1
phosphoglycerate kinase	2	0	0	2
Seed linoleate 13S-lipoxygenase-1	0	2	0	2
Seed linoleate 9S-lipoxygenase-3	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	2	2
Peroxisome proliferator-activated receptor delta	0	0	1	1
Peroxisome proliferator-activated receptor alpha	0	0	1	1
serine/threonine-protein kinase PLK1	1	0	0	1
Metabotropic glutamate receptor 6	0	1	0	1
Acetylcholinesterase	0	1	0	1
5-hydroxytryptamine receptor 4	0	4	0	4
Cytochrome P450 1A2	0	1	0	1
Tyrosine-protein kinase Fyn	0	3	1	4
Muscarinic acetylcholine receptor M4	0	4	0	4
Beta-1 adrenergic receptor	0	2	0	2
Muscarinic acetylcholine receptor M1	0	4	0	4
Beta-3 adrenergic receptor	0	2	0	2
D(2) dopamine receptor	0	2	0	2
Androgen receptor	0	3	0	3
5-hydroxytryptamine receptor 1A	0	2	0	2
Muscarinic acetylcholine receptor M3	0	2	0	2
D(1A) dopamine receptor	0	2	0	2
D(4) dopamine receptor	0	2	0	2
Aromatase	0	0	1	1
Alpha-1D adrenergic receptor	0	2	0	2
Substance-P receptor	0	2	0	2
5-hydroxytryptamine receptor 2A	0	2	0	2
5-hydroxytryptamine receptor 2C	0	4	0	4
5-hydroxytryptamine receptor 1B	0	2	0	2
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Melanocortin receptor 4	0	2	0	2
Melanocortin receptor 5	0	2	0	2
Prostaglandin G/H synthase 2	0	3	0	3
Mu-type opioid receptor	0	2	0	2
D(3) dopamine receptor	0	2	0	2
Kappa-type opioid receptor	0	2	0	2
5-hydroxytryptamine receptor 2B	0	2	0	2
Melanocortin receptor 3	0	2	0	2
Type-2 angiotensin II receptor	0	2	0	2
5-hydroxytryptamine receptor 6	0	2	0	2
Cholinesterase	0	1	0	1
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Calcium release-activated calcium channel protein 1	0	1	0	1
methionyl-tRNA synthetase, putative	0	1	0	1
Platelet-activating factor receptor	0	1	0	1
M-phase inducer phosphatase 1	0	1	0	1
RAC-alpha serine/threonine-protein kinase	0	1	1	2
Chain A, Probable serine/threonine-protein kinase pknB	0	1	0	1
dopamine D1 receptor	1	0	0	1
WRN	1	0	0	1
nonstructural protein 1	0	1	0	1
LANA	0	0	0	1
pyruvate kinase	1	0	0	1
phospholipase A2, group III	0	1	0	1
interferon gamma precursor	0	0	0	1
histone-lysine N-methyltransferase NSD2 isoform 1	0	0	0	1
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
tyrosine-protein kinase Yes	2	0	0	2
dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	0	1
rac GTPase-activating protein 1 isoform a	0	1	0	1
pyruvate kinase PKM isoform b	1	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	2	0	2
Proto-oncogene tyrosine-protein kinase ROS	0	1	0	1
Ornithine decarboxylase	1	0	0	1
Angiotensin-converting enzyme	0	2	0	2
Casein kinase II subunit alpha'	0	1	1	2
Multidrug resistance-associated protein 1	0	1	0	1
Casein kinase II subunit beta	0	1	0	1
Casein kinase II subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
Tyrosine-protein kinase BTK	0	3	2	5
NEDD8-activating enzyme E1 regulatory subunit	0	0	1	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Casein kinase II subunit alpha 3	0	1	0	1
NEDD8-activating enzyme E1 catalytic subunit	0	0	1	1
P2Y purinoceptor 12	0	1	0	1
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
Nuclear receptor corepressor 1	0	1	0	1
Integrin beta-1	0	1	0	1
Leukotriene A-4 hydrolase	0	1	0	1
Integrin alpha-4	0	1	0	1
Nuclear receptor corepressor 2	0	1	0	1
Chain A, Inosine-5'-Monophosphate Dehydrogenase 2	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	0	0	1
Sodium-dependent serotonin transporter	0	2	0	2
Inosine-5'-monophosphate dehydrogenase	0	1	0	2
UDP-glucuronosyltransferase 1A7	0	0	0	1
UDP-glucuronosyltransferase 1A10	0	0	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
vasopressin V1b receptor	1	0	0	1
relaxin receptor 1 isoform 1	1	0	0	1
relaxin receptor 2 isoform 1	1	0	0	1
Bone morphogenetic protein receptor type-1B	0	0	1	1
Cell division cycle 7-related protein kinase	0	0	1	1
Serine/threonine-protein kinase PLK4	0	0	1	1
ATP-dependent RNA helicase DDX3X	0	0	1	1
Pyridoxal kinase	0	0	1	1
Citron Rho-interacting kinase	0	0	1	1
Serine/threonine-protein kinase Chk1	0	0	1	1
Aurora kinase A	0	1	1	2
Cyclin-G-associated kinase	0	0	1	1
Ephrin type-B receptor 6	0	0	1	1
Peroxisomal acyl-coenzyme A oxidase 3	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 2	0	0	1	1
Mitotic checkpoint serine/threonine-protein kinase BUB1	0	0	1	1
Testosterone 17-beta-dehydrogenase 3	0	1	0	1
Dynamin-like 120 kDa protein, mitochondrial	0	0	1	1
Putative nucleoside diphosphate kinase	0	0	1	1
Tyrosine-protein kinase JAK2	0	2	0	2
Rho-associated protein kinase 2	0	0	1	1
Serine/threonine-protein kinase ULK1	0	0	1	1
Serine/threonine-protein kinase/endoribonuclease IRE1	0	0	1	1
Ribosomal protein S6 kinase alpha-5	0	0	1	1
U5 small nuclear ribonucleoprotein 200 kDa helicase	0	0	1	1
Ribosomal protein S6 kinase alpha-4	0	0	1	1
Serine/threonine-protein kinase 16	0	0	1	1
Serine/threonine-protein kinase 10	0	0	1	1
Serine/threonine-protein kinase D3	0	0	1	1
Structural maintenance of chromosomes protein 2	0	0	1	1
Mitogen-activated protein kinase kinase kinase 6	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 4	0	0	1	1
Serine/threonine-protein kinase LATS1	0	0	1	1
Serine/threonine-protein kinase PAK 4	0	0	1	1
Tyrosine-protein kinase ABL1	0	0	1	1
High affinity nerve growth factor receptor	0	0	1	1
Guanine nucleotide-binding protein G(i) subunit alpha-2	0	0	1	1
ADP/ATP translocase 2	0	0	1	1
Protein kinase C beta type	0	0	1	1
Tyrosine-protein kinase Lck	0	1	1	2
Glycogen phosphorylase, liver form	0	0	1	1
Tyrosine-protein kinase Fes/Fps	0	0	1	1
Macrophage colony-stimulating factor 1 receptor	0	1	0	1
Adenine phosphoribosyltransferase	0	0	1	1
Tyrosine-protein kinase Yes	0	1	1	2
Tyrosine-protein kinase Lyn	0	1	1	2
Proto-oncogene tyrosine-protein kinase receptor Ret	0	1	1	2
Insulin-like growth factor 1 receptor	0	0	1	1
Signal recognition particle receptor subunit alpha	0	0	1	1
Cytochrome c1, heme protein, mitochondrial	0	0	1	1
Hepatocyte growth factor receptor	0	0	1	1
Tyrosine-protein kinase HCK	0	1	1	2
Tyrosine-protein kinase Fgr	0	1	0	1
Serine/threonine-protein kinase A-Raf	0	0	1	1
Glycogen phosphorylase, brain form	0	0	1	1
Breakpoint cluster region protein	0	0	1	1
Serine/threonine-protein kinase pim-1	0	0	1	1
Cyclin-dependent kinase 4	0	0	1	1
ADP/ATP translocase 3	0	0	1	1
Proto-oncogene tyrosine-protein kinase Src	0	1	1	2
cAMP-dependent protein kinase type II-alpha regulatory subunit	0	0	1	1
Serine/threonine-protein kinase B-raf	0	0	1	1
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	0	0	1	1
Tyrosine-protein kinase Fer	0	0	1	1
Protein kinase C alpha type	0	0	1	1
cAMP-dependent protein kinase catalytic subunit alpha	0	0	1	1
General transcription and DNA repair factor IIH helicase subunit XPD	0	0	1	1
Ras-related protein Rab-6A	0	0	1	1
Ephrin type-A receptor 1	0	0	1	1
Receptor tyrosine-protein kinase erbB-3	0	1	0	1
Multifunctional protein ADE2	0	0	1	1
Nucleoside diphosphate kinase B	0	0	1	1
cAMP-dependent protein kinase catalytic subunit gamma	0	0	1	1
cAMP-dependent protein kinase catalytic subunit beta	0	0	1	1
Ferrochelatase, mitochondrial	0	0	1	1
Ribosomal protein S6 kinase beta-1	0	0	1	1
Tyrosine-protein kinase JAK1	0	2	1	3
G1/S-specific cyclin-E1	0	1	0	1
Cyclin-dependent kinase 2	0	1	1	2
Beta-adrenergic receptor kinase 1	0	0	1	1
Probable ATP-dependent RNA helicase DDX6	0	0	1	1
Mitogen-activated protein kinase 3	0	0	1	1
MAP/microtubule affinity-regulating kinase 3	0	0	1	1
Mitogen-activated protein kinase 1	0	0	1	1
Ephrin type-A receptor 2	0	1	1	2
Ephrin type-B receptor 2	0	0	1	1
Non-receptor tyrosine-protein kinase TYK2	0	0	1	1
Phosphatidylethanolamine-binding protein 1	0	0	1	1
Wee1-like protein kinase	0	0	1	1
Heme oxygenase 2	0	0	1	1
S-adenosylmethionine synthase isoform type-2	0	0	1	1
DnaJ homolog subfamily A member 1	0	0	1	1
RAC-beta serine/threonine-protein kinase	0	0	1	1
Dual specificity protein kinase TTK	0	0	1	1
DNA replication licensing factor MCM4	0	0	1	1
Myosin-10	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 2	0	1	1	2
Receptor-type tyrosine-protein kinase FLT3	0	2	1	3
Bone morphogenetic protein receptor type-1A	0	0	1	1
Activin receptor type-1B	0	0	1	1
TGF-beta receptor type-1	0	0	1	1
TGF-beta receptor type-2	0	0	1	1
Tyrosine-protein kinase CSK	0	1	1	2
Glycine--tRNA ligase	0	0	1	1
Protein kinase C iota type	0	0	1	1
Exosome RNA helicase MTR4	0	0	1	1
Tyrosine-protein kinase Tec	0	1	1	2
Tyrosine-protein kinase TXK	0	1	1	2
Tyrosine-protein kinase ABL2	0	0	1	1
Tyrosine-protein kinase FRK	0	1	1	2
G protein-coupled receptor kinase 6	0	0	1	1
Tyrosine-protein kinase SYK	0	1	1	2
26S proteasome regulatory subunit 6B	0	0	1	1
Mitogen-activated protein kinase 8	0	0	1	1
Mitogen-activated protein kinase 9	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 3	0	0	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	0	0	1	1
Casein kinase I isoform delta	0	0	1	1
MAP kinase-activated protein kinase 2	0	0	1	1
Elongation factor Tu, mitochondrial	0	0	1	1
Choline-phosphate cytidylyltransferase A	0	0	1	1
Casein kinase I isoform epsilon	0	0	1	1
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	0	0	1	1
Dual specificity protein kinase CLK1	0	0	1	1
Dual specificity protein kinase CLK2	0	0	1	1
Glycogen synthase kinase-3 alpha	0	0	1	1
Glycogen synthase kinase-3 beta	0	0	1	1
Cyclin-dependent kinase 7	0	0	1	1
Cyclin-dependent kinase 9	0	0	1	1
Ras-related protein Rab-27A	0	0	1	1
Tyrosine-protein kinase Blk	0	1	1	2
Interleukin-1 receptor-associated kinase 1	0	0	1	1
Ribosomal protein S6 kinase alpha-3	0	0	1	1
Cytoplasmic tyrosine-protein kinase BMX	0	2	1	3
cAMP-dependent protein kinase catalytic subunit PRKX	0	0	1	1
Serine/threonine-protein kinase Nek2	0	0	1	1
Serine/threonine-protein kinase Nek3	0	0	1	1
Tyrosine-protein kinase JAK3	0	1	1	2
Dual specificity mitogen-activated protein kinase kinase 6	0	0	1	1
Serine/threonine-protein kinase PLK1	0	0	1	1
LIM domain kinase 1	0	0	1	1
LIM domain kinase 2	0	0	1	1
Mitogen-activated protein kinase 10	0	0	1	1
Tyrosine--tRNA ligase, cytoplasmic	0	0	1	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	1	2
Ephrin type-B receptor 3	0	0	1	1
Ephrin type-A receptor 5	0	0	1	1
Ephrin type-B receptor 4	0	0	1	1
Ephrin type-A receptor 4	0	0	1	1
Adenylate kinase 2, mitochondrial	0	0	1	1
Ras-related protein Rab-10	0	0	1	1
Actin-related protein 3	0	0	1	1
Actin-related protein 2	0	0	1	1
GTP-binding nuclear protein Ran	0	0	1	1
Casein kinase I isoform gamma-2	0	0	1	1
Cyclin-dependent kinase 3	0	0	1	1
Cyclin-dependent kinase 6	0	0	1	1
Cyclin-dependent-like kinase 5	0	0	1	1
Cyclin-dependent kinase 16	0	0	1	1
Cyclin-dependent kinase 17	0	0	1	1
ATP-dependent 6-phosphofructokinase, platelet type	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 1	0	0	1	1
Protein kinase C theta type	0	0	1	1
Activin receptor type-1	0	0	1	1
Macrophage-stimulating protein receptor	0	0	1	1
Focal adhesion kinase 1	0	0	1	1
Protein kinase C delta type	0	0	1	1
Activated CDC42 kinase 1	0	0	1	1
Epithelial discoidin domain-containing receptor 1	0	0	1	1
Tyrosine-protein kinase ITK/TSK	0	1	1	2
Mitogen-activated protein kinase kinase kinase kinase 2	0	0	1	1
Tyrosine-protein kinase Mer	0	0	1	1
Serine/threonine-protein kinase 4	0	0	1	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	1	2
Dual specificity mitogen-activated protein kinase kinase 5	0	0	1	1
Mitogen-activated protein kinase 7	0	0	1	1
Serine/threonine-protein kinase PAK 2	0	0	1	1
Serine/threonine-protein kinase 3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 1	0	0	1	1
Integrin-linked protein kinase	0	0	1	1
Rho-associated protein kinase 1	0	0	1	1
Non-receptor tyrosine-protein kinase TNK1	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit gamma	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit delta	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	1	1
Activin receptor type-2B	0	0	1	1
Bone morphogenetic protein receptor type-2	0	0	1	1
Protein-tyrosine kinase 6	0	1	1	2
cGMP-dependent protein kinase 1	0	0	1	1
Cyclin-dependent kinase 13	0	0	1	1
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	0	0	1	1
Protein-tyrosine kinase 2-beta	0	0	1	1
Maternal embryonic leucine zipper kinase	0	0	1	1
Structural maintenance of chromosomes protein 1A	0	0	1	1
Chromodomain-helicase-DNA-binding protein 4	0	0	1	1
Serine/threonine-protein kinase 38	0	0	1	1
Receptor tyrosine-protein kinase erbB-4	0	1	1	2
Ephrin type-A receptor 7	0	0	1	1
Delta(24)-sterol reductase	0	0	1	1
Ribosomal protein S6 kinase alpha-1	0	1	1	2
Myosin light chain kinase, smooth muscle	0	0	1	1
Mitogen-activated protein kinase 11	0	0	1	1
Serine/threonine-protein kinase STK11	0	0	1	1
Serine/threonine-protein kinase N1	0	0	1	1
Serine/threonine-protein kinase N2	0	0	1	1
Mitogen-activated protein kinase 14	0	0	1	1
Calcium/calmodulin-dependent protein kinase type IV	0	0	1	1
Mitogen-activated protein kinase kinase kinase 11	0	0	1	1
MAP kinase-activated protein kinase 3	0	0	1	1
Discoidin domain-containing receptor 2	0	0	1	1
AP2-associated protein kinase 1	0	0	1	1
Myosin light chain kinase 3	0	0	1	1
Putative heat shock protein HSP 90-beta 2	0	0	1	1
Rab-like protein 3	0	0	1	1
Sigma intracellular receptor 2	0	1	0	1
Serine/threonine-protein kinase MRCK alpha	0	0	1	1
Serine/threonine-protein kinase MRCK gamma	0	0	1	1
Acyl-CoA dehydrogenase family member 10	0	0	1	1
Serine/threonine-protein kinase ULK3	0	0	1	1
Uncharacterized protein FLJ45252	0	0	1	1
Acyl-CoA dehydrogenase family member 11	0	0	1	1
Serine/threonine-protein kinase/endoribonuclease IRE2	0	0	1	1
Serine/threonine-protein kinase MARK2	0	0	1	1
ATP-dependent RNA helicase DHX30	0	0	1	1
Serine/threonine-protein kinase TAO1	0	0	1	1
STE20-related kinase adapter protein alpha	0	0	1	1
Myosin-14	0	0	1	1
AarF domain-containing protein kinase 1	0	0	1	1
ATP-dependent RNA helicase DDX42	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 3	0	0	1	1
MAP kinase-activated protein kinase 5	0	0	1	1
Misshapen-like kinase 1	0	0	1	1
Atypical kinase COQ8A, mitochondrial	0	0	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	0	0	1	1
Mitogen-activated protein kinase 15	0	0	1	1
Serine/threonine-protein kinase Nek9	0	0	1	1
Serine/threonine-protein kinase Nek7	0	0	1	1
ATP-dependent RNA helicase DDX1	0	0	1	1
Nuclear receptor subfamily 4 group A member 3	0	1	0	1
Mitogen-activated protein kinase kinase kinase kinase 1	0	0	1	1
MAP/microtubule affinity-regulating kinase 4	0	0	1	1
Calcium/calmodulin-dependent protein kinase type 1G	0	0	1	1
Serine/threonine-protein kinase Nek1	0	0	1	1
PAS domain-containing serine/threonine-protein kinase	0	0	1	1
Calcium/calmodulin-dependent protein kinase kinase 2	0	0	1	1
EKC/KEOPS complex subunit TP53RK	0	0	1	1
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 5	0	0	1	1
Mitogen-activated protein kinase kinase kinase 3	0	0	1	1
Eukaryotic translation initiation factor 2-alpha kinase 1	0	0	1	1
Peroxiredoxin-like 2A	0	1	0	1
Nucleolar GTP-binding protein 1	0	0	1	1
Serine/threonine-protein kinase D2	0	0	1	1
NUAK family SNF1-like kinase 2	0	0	1	1
RNA cytidine acetyltransferase	0	0	1	1
Serine/threonine-protein kinase SIK2	0	0	1	1
STE20-like serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase TAO3	0	0	1	1
dCTP pyrophosphatase 1	0	0	1	1
Dual specificity protein kinase CLK4	0	0	1	1
Casein kinase I isoform gamma-1	0	0	1	1
Serine/threonine-protein kinase PAK 6	0	0	1	1
Phenylalanine--tRNA ligase beta subunit	0	0	1	1
BMP-2-inducible protein kinase	0	0	1	1
Obg-like ATPase 1	0	0	1	1
Midasin	0	0	1	1
Interleukin-1 receptor-associated kinase 4	0	0	1	1
Mitogen-activated protein kinase kinase kinase 20	0	0	1	1
Cyclin-dependent kinase 12	0	0	1	1
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	0	0	1	1
Serine/threonine-protein kinase 26	0	0	1	1
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	0	0	1	1
Serine/threonine-protein kinase NLK	0	0	1	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	1	2
Serine/threonine-protein kinase TBK1	0	0	1	1
Septin-9	0	0	1	1
Ribosomal protein S6 kinase alpha-6	0	0	1	1
TRAF2 and NCK-interacting protein kinase	0	0	1	1
Serine/threonine-protein kinase TAO2	0	0	1	1
Serine/threonine-protein kinase ICK	0	0	1	1
RAC-gamma serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase SIK3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 2	0	0	1	1
Thyroid hormone receptor-associated protein 3	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 5	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 3	0	0	1	1
Serine/threonine-protein kinase MRCK beta	0	0	1	1
Interleukin-1 receptor-associated kinase 3	0	0	1	1
Serine/threonine-protein kinase 24	0	0	1	1
Casein kinase I isoform gamma-3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 4	0	0	1	1
Chain A, Immunoglobulin	0	0	1	1
Chain B, Immunoglobulin	0	0	1	1
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Muscarinic acetylcholine receptor M1	0	0	1	1
Muscarinic acetylcholine receptor M3	0	0	1	1
Muscarinic acetylcholine receptor M4	0	0	1	1
Muscarinic acetylcholine receptor M5	0	0	1	1
Muscarinic acetylcholine receptor M2	0	0	1	1
Muscarinic acetylcholine receptor M1	0	0	1	2
Muscarinic acetylcholine receptor M4	0	0	1	2
Delta-type opioid receptor	0	0	0	1
Kappa-type opioid receptor	0	0	0	1
Lysosomal Pro-X carboxypeptidase	0	1	0	1
Mu-type opioid receptor	0	0	0	1
Cholinesterase	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	2	0	2
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Muscarinic acetylcholine receptor M5	0	0	1	2
Sigma non-opioid intracellular receptor 1	0	3	0	3
Muscarinic acetylcholine receptor M3	0	0	1	2
Muscarinic acetylcholine receptor M2	0	0	1	2
Sigma non-opioid intracellular receptor 1	0	2	0	2
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Lysozyme	0	0	1	1
Chain A, Lysozyme	0	0	1	1
Chain A, Lysozyme	0	0	1	1
Chain A, Lysozyme	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Endolysin	0	0	1	1
Sulfotransferase 1A1	0	0	0	1
Cannabinoid receptor 1	0	1	0	1
Carbonic anhydrase	0	1	0	1
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 3	0	2	0	2
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	2	0	2
beta-2 adrenergic receptor	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Neuronal acetylcholine receptor subunit alpha-4	2	0	0	2
Neuronal acetylcholine receptor subunit beta-2	2	0	0	2
Sterol 14-alpha-demethylase	0	0	2	2
14-alpha sterol demethylase	0	0	2	2
14-alpha sterol demethylase	0	0	2	2
luciferase	0	0	0	1
Fatty acid-binding protein, liver	0	1	0	1
Estrogen receptor	0	2	0	2
Glucocorticoid receptor	0	2	1	8
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Glycine receptor subunit alpha-1	0	2	0	2
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	2	0	2
Glutamine synthetase	0	0	1	1
Glycine receptor subunit beta	0	2	0	2
Glycine receptor subunit alpha-2	0	2	0	2
Glycine receptor subunit alpha-3	0	2	0	2
Histamine H1 receptor	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	1	3
dual specificity protein phosphatase 3	0	1	0	1
low molecular weight phosphotyrosine protein phosphatase isoform c	0	1	0	1
tyrosine-protein phosphatase non-receptor type 22 isoform 1	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Solute carrier family 22 member 1	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Estrogen receptor	0	0	1	1
Beta-hexosaminidase subunit alpha	0	1	0	2
Beta-hexosaminidase subunit beta	0	1	0	1
Dihydrofolate reductase	0	2	1	4
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Dihydrofolate reductase	0	2	0	2
Substance-K receptor	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Pteridine reductase 1	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Trace amine-associated receptor 5	0	0	1	1
Estrogen receptor beta	0	0	1	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Multidrug and toxin extrusion protein 1	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Chain A, 6,7-Dimethyl-8-ribityllumazine Synthase	0	0	1	1
Chain B, 6,7-Dimethyl-8-ribityllumazine Synthase	0	0	1	1
Chain A, Breast cancer type 1 susceptibility protein	1	0	0	1
Chain H, Immunoglobulin Igg1 Heavy chain	0	0	1	1
Chain L, Immunoglobulin Igg1 Lambda Light Chain	0	0	1	1
Chain A, DODECIN	0	0	1	1
Chain A, DODECIN	0	0	1	1
Chain C, DODECIN	0	0	1	1
Chain E, DODECIN	0	0	1	1
thyrotropin-releasing hormone receptor	1	0	0	1
caspase-1 isoform alpha precursor	1	0	0	1
Riboflavin-binding protein	0	1	1	2
60 kDa chaperonin	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	1	0	1
Caspase-7	1	0	0	1
10 kDa heat shock protein, mitochondrial	0	1	0	1
Thiosulfate sulfurtransferase	0	1	0	1
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, 146aa long hypothetical transcriptional regulator	0	0	1	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain B, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain C, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Anthranilate phosphoribosyltransferase	0	1	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Polymerase acidic protein	0	0	1	1
Stromelysin-1	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
High mobility group protein B1	0	0	1	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Prostaglandin G/H synthase 1	0	1	0	1
Cystathionine gamma-lyase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Tyrosinase	0	1	0	1
NAD(P)H dehydrogenase [quinone] 1	0	0	0	1
Chain A, MALTOPORIN	0	0	1	1
Chain B, MALTOPORIN	0	0	1	1
cystic fibrosis transmembrane conductance regulator	0	1	0	1
C-8 sterol isomerase	0	1	0	1
Squalene monooxygenase	0	1	0	1
Squalene monooxygenase	0	2	0	2
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	1	0	1
HLA class I histocompatibility antigen, A alpha chain	0	0	1	1
Solute carrier family 15 member 1	0	1	0	1
Valacyclovir hydrolase	0	0	0	1
Chain A, Arginase 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
Cholesterol side-chain cleavage enzyme, mitochondrial	0	0	1	1
Cholesterol 24-hydroxylase	0	2	1	3
Albumin	0	0	1	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Protease	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
PTK2B protein tyrosine kinase 2 beta	0	1	0	1
serine/threonine-protein kinase 33 isoform a	0	0	1	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

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