A chelator that is any compound containing a ligand (typically organic) which is able to form a bond to a central copper atom at two or more points.
| Member | Definition | Class |
|---|
| 1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid | An azamacrocyle in which four nitrogen atoms at positions 1, 4, 7 and 10 of a twelve-membered ring are each substituted with a carboxymethyl group. | DOTA |
| clioquinol | A monohydroxyquinoline that is quinolin-8-ol in which the hydrogens at positions 5 and 7 are replaced by chlorine and iodine, respectively. It has antibacterial and atifungal properties, and is used in creams for the treatment of skin infections. It has also been investigated as a chelator of copper and zinc ions for the possible treatment of Alzheimer's disease. | 5-chloro-7-iodoquinolin-8-ol |
| ditiocarb | A member of the class of dithiocarbamic acids that is diethylcarbamic acid in which both of the oxygens are replaced by sulfur. | diethyldithiocarbamic acid |
| edetic acid | | ethylenediaminetetraacetic acid |
| n,n,n',n'-tetrakis(2-pyridylmethyl)ethylenediamine | An N-substituted diamine that is ethylenediamine in which the four amino hydrogens are replaced by 2-pyridylmethyl groups. | N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine |
| neocuproine | A member of the class of phenanthrolines that is 1,10-phenanthroline bearing two methyl substituents at positions 2 and 9. | neocuproine |
| penicillamine | An optically active form of penicillamine having D-configuration. Pharmaceutical form (L-form is toxic) of chelating agent used to treat heavy metal poisoning. | D-penicillamine |
| pentetic acid | | pentetic acid |
| tetraethylenepentamine | | tetraethylenepentamine |
| trientine | A polyazaalkane that is decane in which the carbon atoms at positions 1, 4, 7 and 10 are replaced by nitrogens. | 2,2,2-tetramine |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 11.6347 | 1 | 5 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 74.9418 | 2 | 2 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 21.8403 | 2 | 2 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 24.2279 | 1 | 4 |
| Alpha-synuclein | Homo sapiens (human) | Potency | 4.0075 | 1 | 2 |
| apical membrane antigen 1, AMA1 | Plasmodium falciparum 3D7 | Potency | 12.3807 | 1 | 2 |
| AR protein | Homo sapiens (human) | Potency | 25.1557 | 8 | 14 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 28.2302 | 3 | 5 |
| arylsulfatase A | Homo sapiens (human) | Potency | 1.1995 | 1 | 1 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 32.1328 | 2 | 2 |
| Ataxin-2 | Homo sapiens (human) | Potency | 17.3696 | 1 | 3 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 0.4256 | 1 | 1 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 19.6780 | 2 | 4 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 0.4467 | 2 | 2 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 15.1030 | 2 | 5 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 11.1465 | 2 | 4 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 22.1074 | 1 | 4 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 100.0000 | 1 | 1 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 28.0076 | 1 | 3 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 79.4328 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 0.0056 | 1 | 1 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 22.5381 | 3 | 6 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 4.0057 | 1 | 10 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 100.0000 | 1 | 1 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 0.0025 | 1 | 1 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 24.5454 | 1 | 1 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 31.6228 | 2 | 3 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 8.2206 | 1 | 4 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 27.2505 | 1 | 1 |
| Disintegrin and metalloproteinase domain-containing protein 17 | Homo sapiens (human) | Potency | 1.7901 | 1 | 2 |
| DNA dC->dU-editing enzyme APOBEC-3F isoform a | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 62.1554 | 1 | 4 |
| endonuclease IV | Escherichia coli | Potency | 0.7079 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 22.3021 | 10 | 23 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 33.3938 | 2 | 6 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 29.6386 | 6 | 14 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 6.1371 | 1 | 9 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 52.5330 | 3 | 3 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 21.5234 | 1 | 3 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 2 |
| GALC protein | Homo sapiens (human) | Potency | 0.3162 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 2 |
| geminin | Homo sapiens (human) | Potency | 11.5806 | 2 | 9 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 16.5593 | 3 | 10 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 7.3133 | 1 | 2 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 16.4976 | 4 | 8 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 23.7112 | 1 | 4 |
| heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 5.8208 | 2 | 3 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 3.9510 | 1 | 6 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 54.5416 | 2 | 5 |
| huntingtin isoform 2 | Homo sapiens (human) | Potency | 11.7819 | 1 | 3 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 19.1428 | 1 | 3 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 4.5385 | 3 | 5 |
| IDH1 | Homo sapiens (human) | Potency | 2.9053 | 1 | 2 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 4.4668 | 1 | 1 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 15.8154 | 1 | 2 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 15.8154 | 1 | 2 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 6.2480 | 1 | 7 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 31.6228 | 1 | 1 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 0.1413 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 23.1432 | 2 | 5 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 11.2154 | 1 | 3 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 18.2368 | 4 | 10 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 4.4652 | 1 | 2 |
| nuclear factor NF-kappa-B p105 subunit isoform 1 | Homo sapiens (human) | Potency | 17.7828 | 1 | 1 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 23.7101 | 1 | 1 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 1.3761 | 2 | 10 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 31.9400 | 3 | 6 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 16.4443 | 2 | 5 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 95.2834 | 1 | 1 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 36.1950 | 5 | 7 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 31.8039 | 5 | 6 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 49.7400 | 1 | 3 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 0.0141 | 1 | 1 |
| polyprotein | Zika virus | Potency | 35.4813 | 1 | 1 |
| polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | Potency | 0.7079 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 3.9510 | 1 | 3 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 22.1060 | 1 | 2 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 32.7053 | 2 | 3 |
| progesterone receptor | Homo sapiens (human) | Potency | 4.7842 | 2 | 3 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 26.5565 | 2 | 8 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 0.2239 | 1 | 1 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 70.7946 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 34.2675 | 3 | 8 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 8.8072 | 3 | 5 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 38.8381 | 1 | 1 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 38.8381 | 1 | 1 |
| Smad3 | Homo sapiens (human) | Potency | 18.2928 | 1 | 3 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 19.9526 | 1 | 1 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 15.9775 | 1 | 3 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 10.1578 | 1 | 2 |
| TDP1 protein | Homo sapiens (human) | Potency | 16.2343 | 2 | 12 |
| thioredoxin glutathione reductase | Schistosoma mansoni | Potency | 50.1187 | 1 | 1 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 43.6880 | 1 | 2 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 25.6400 | 2 | 5 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 23.8362 | 2 | 3 |
| ubiquitin carboxyl-terminal hydrolase 2 isoform a | Homo sapiens (human) | Potency | 1.7901 | 1 | 2 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 0.0141 | 1 | 1 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 0.0141 | 1 | 1 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 42.2395 | 2 | 2 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 1.3072 | 2 | 5 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 31.7776 | 2 | 2 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 48.5236 | 1 | 3 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 23.7112 | 1 | 4 |
| Vpr | Human immunodeficiency virus 1 | Potency | 39.8107 | 1 | 1 |