Page last updated: 2024-08-05 11:02:15
dihydroxyflavanone
Any hydroxyflavanone carrying two hydroxy substituents.
ChEBI ID: 38749
Members (15)
| Member | Definition | Role |
|---|---|---|
| (2S)-5,7-dihydroxy-6,8-dimethylflavanone | A dihydroxyflavanone that is (2S)-flavanone substituted by hydroxy groups at positions 5 and 7 and methyl groups at positions 6 and 8. Isolated from the buds of Cleistocalyx operculatus, it has been shown to exhibit inhibitory effects on the viral neuraminidases from two influenza viral strains, H1N1 and H9N2. | (2S)-5,7-dihydroxy-6,8-dimethylflavanone |
| 2'-methoxykurarinone | A dimethoxyflavanone that is (2S)-(-)-kurarinone in which the hydroxy group at position 2' is replaced by a methoxy group. Isolated from the roots of Sophora flavescens, it exhibits cytotoxicity against human myeloid leukemia HL-60 cells. | (2S)-2'-methoxykurarinone |
| 4',7-dihydroxyflavanone | A dihydroxyflavanone in which the two hydroxy substituents are located at positions 4' and 7. | 4',7-dihydroxyflavanone |
| 7,8-dihydroxyflavanone | A dihydroxyflavanone with hydroxy substituents at positions 7 and 8. Isolated from the seeds of Alpinia katsumadai, it acts as a an inhibitor for Jun-Fos-DNA complex formation and exhibits antineoplastic activity. | 7,8-dihydroxyflavanone |
| diosmin | A disaccharide derivative that consists of diosmetin substituted by a 6-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage. | diosmin |
| glabranin | A dihydroxyflavanone that is pinocembrin substituted by a prenyl group at position 8. | glabranin |
| hesperidin | A disaccharide derivative that consists of hesperetin substituted by a 6-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage. | hesperidin |
| isonaringin | A disaccharide derivative that is (S)-naringenin substituted by a 6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage. | narirutin |
| isosakuranetin | A dihydroxyflavanone that is flavanone substituted by hydroxy groups at positions 5 and 7 and a methoxy group at position 4' (the 2S stereoisomer). | 4'-methoxy-5,7-dihydroxyflavanone |
| matteucinol | A dihydroxyflavanone that is (2S)-flavanone with hydroxy groups at positions 5 and 7, methyl groups at positions 6 and 8 and a methoxy group at position 4'. | matteucinol |
| naringin | A disaccharide derivative that is (S)-naringenin substituted by a 2-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage. | naringin |
| pinocembrin | A dihydroxyflavanone in which the two hydroxy groups are located at positions 5 and 7. A natural product found in Piper sarmentosum and Cryptocarya chartacea. | pinocembrin |
| prunin protein, prunus | A flavanone 7-O-beta-D-glucoside that is (S)-naringenin substituted by a beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage. | naringenin 7-O-beta-D-glucoside |
| sakuranetin | A flavonoid phytoalexin that is (S)-naringenin in which the hydroxy group at position 7 is replaced by a methoxy group. | sakuranetin |
| sophoranone | A dihydroxyflavanone that is (2S)-flavanone substituted by hydroxy groups at positions 7 and 4' and prenyl groups at positions 3' and 5' respectively. | sophoranone |
Research
Studies (3,325)
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|---|---|
| pre-1990 | 168 (5.05) | 18.7374 |
| 1990's | 196 (5.89) | 18.2507 |
| 2000's | 570 (17.14) | 29.6817 |
| 2010's | 1,574 (47.34) | 24.3611 |
| 2020's | 817 (24.57) | 2.80 |
Study Types
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|---|---|
| Trials | 253 (6.57%) | 5.53% |
| Reviews | 198 (5.15%) | 6.00% |
| Case Studies | 18 (0.47%) | 4.05% |
| Observational | 13 (0.34%) | 0.25% |
| Other | 3,366 (87.47%) | 84.16% |