Page last updated: 2024-08-05 15:24:57
PPARgamma agonist
A PPAR modulator which activates the peroxisome proliferator-activated receptor-gamma.
ChEBI ID: 71554
Members (5)
| Member | Definition | Class |
|---|---|---|
| 6,7,4'-trihydroxyisoflavone | A hydroxyisoflavone that is daidzein bearing an additional hydroxy substituent at position 6. | 4',6,7-trihydroxyisoflavone |
| monascin | An organic heterotricyclic compound that is 3a,4,8,9a-tetrahydro-2H-furo[3,2-g][2]benzopyran-2,9(3H)-dione that is substituted at positions 3, 6, and 9a by hexanoyl, (1E)-prop-1-en-1-yl and methyl groups, respectively (the 3S,3aR,9aR diastereoisomer). One of the azaphilonoid pigments in extracts of Monascus pilosus-fermented rice (red-mould rice), it is a potent inhibitor of carcinogenesis measured against chemical- or UV-initiated, phorbol-promoted mouse skin tumours. | monascin |
| pioglitazone | A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity. | pioglitazone |
| protectin d1 | A dihydroxydocosahexaenoic acid that is (4Z,7Z,11E,13E,15Z,19Z)-docosahexaenoic acid in which the two hydroxy substituents are located at positions 10 and 17 (the 10R,17S-stereoisomer). Protectin D1 is one of the specialised proresolving mediators. When produced in neural tissues, it is called neuroprotectin D1 | protectin D1 |
| saroglitazar | A monocarboxylic acid that is (2S)-2-ethoxy-3-(p-ethoxyphenyl)propanoic acid in which one of the methyl hydrogens of the p-ethoxy substituent has been replaced by the nitrogen of 2-methyl-5-[4-(methylthio)phenyl]-1H-pyrrole. An agonist at the subtypes alpha and gamma of the peroxisome proliferator-activated receptor (PPAR) with predominant PPARalpha activity, it is used in the treatment of type 2 diabetes. | saroglitazar |
Research
Studies (4,467)
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (0.02) | 18.7374 |
| 1990's | 135 (3.02) | 18.2507 |
| 2000's | 1,606 (35.95) | 29.6817 |
| 2010's | 2,190 (49.03) | 24.3611 |
| 2020's | 535 (11.98) | 2.80 |
Study Types
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 837 (18.11%) | 5.53% |
| Reviews | 574 (12.42%) | 6.00% |
| Case Studies | 110 (2.38%) | 4.05% |
| Observational | 23 (0.50%) | 0.25% |
| Other | 3,078 (66.59%) | 84.16% |
Protein Targets (40)
Potency Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 2.5119 | 1 | 1 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 0.1552 | 2 | 2 |
| TDP1 protein | Homo sapiens (human) | Potency | 26.1011 | 2 | 2 |
| tyrosine-protein kinase Yes | Homo sapiens (human) | Potency | 1.7291 | 1 | 1 |
Inhibition Measurements
Activation Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Free fatty acid receptor 1 | Homo sapiens (human) | EC50 | 812.8310 | 1 | 1 |
| Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | EC50 | 0.5500 | 1 | 2 |
| Muscarinic acetylcholine receptor M2 | Rattus norvegicus (Norway rat) | EC50 | 0.5500 | 1 | 2 |
| Muscarinic acetylcholine receptor M3 | Rattus norvegicus (Norway rat) | EC50 | 0.5500 | 1 | 2 |
| Muscarinic acetylcholine receptor M4 | Rattus norvegicus (Norway rat) | EC50 | 0.5500 | 1 | 2 |
| Muscarinic acetylcholine receptor M5 | Rattus norvegicus (Norway rat) | EC50 | 0.5500 | 1 | 2 |
| Peroxisome proliferator-activated receptor alpha | Homo sapiens (human) | EC50 | 6.6867 | 3 | 3 |
| Peroxisome proliferator-activated receptor gamma | Homo sapiens (human) | EC50 | 0.8027 | 36 | 36 |
| Peroxisome proliferator-activated receptor gamma | Mus musculus (house mouse) | EC50 | 0.6200 | 2 | 2 |
| Peroxisome proliferator-activated receptor gamma | Homo sapiens (human) | Kd | 0.8710 | 1 | 1 |
Other Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Peroxisome proliferator-activated receptor gamma | Homo sapiens (human) | Activity | 3.1400 | 2 | 2 |