Page last updated: 2024-08-05 15:27:44

anabolic agent

A compound which stimulates anabolism and inhibits catabolism. Anabolic agents stimulate the development of muscle mass, strength, and power.

ChEBI ID: 36413

Members (10)

MemberDefinitionClass
1-testosteroneAn anabolic steroid that differs from testosterone by having a 1,2-double bond instead of a 4,5-double bond in its A ring. A potent androgen with anabolic properties, it was legally sold as a prohormone in the U.S.A. until 2005, when it was reclassified as a Schedule III drug.Delta(1)-dihydrotestosterone
dromostanolonemetholone
ethylestrenolA 17beta-hydroxy steroid that is estrane containing a double bond between positions 4 and 5 and substituted by an ethyl group and a hydroxy group at the 17alpha and 17beta positions, respectively. It is an anabolic steroid that has little androgenic effect and only slight progestational activity. It has been used to promote growth in boys with delayed bone growth.ethylestrenol
fluoxymesteronefluoxymesterone
methyltestosteroneA 17beta-hydroxy steroid that is testosterone bearing a methyl group at the 17alpha position.methyltestosterone
miboleroneAn androgen that is nalandrone carrying two methyl substituents at positions 7alpha and 17.mibolerone
myrceneA monoterpene that is octa-1,6-diene bearing methylene and methyl substituents at positions 3 and 7 respectively.beta-myrcene
nandrolone phenpropionatenandrolone phenpropionate
oxandroloneoxandrolone
stanozololAn organic heteropentacyclic compound resulting from the formal condensation of the 3-keto-aldehyde moiety of oxymetholone with hydrazine. Like oxymetholone, it is a synthetic anabolic steroid. It has both anabolic and androgenic properties, and has been used to treat hereditary angioedema and various vascular disorders. It has also been widely abused by professional athletes.stanozolol

Research

Studies (3,339)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-19901,901 (56.93)18.7374
1990's441 (13.21)18.2507
2000's438 (13.12)29.6817
2010's441 (13.21)24.3611
2020's118 (3.53)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials341 (9.00%)5.53%
Reviews174 (4.59%)6.00%
Case Studies241 (6.36%)4.05%
Observational1 (0.03%)0.25%
Other3,033 (80.03%)84.16%

Protein Targets (89)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
acetylcholinesteraseHomo sapiens (human)Potency0.346711
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency31.622811
AR proteinHomo sapiens (human)Potency4.55691257
aryl hydrocarbon receptorHomo sapiens (human)Potency76.958811
Ataxin-2Homo sapiens (human)Potency21.689911
ATPase family AAA domain-containing protein 5Homo sapiens (human)Potency21.689911
caspase 7, apoptosis-related cysteine proteaseHomo sapiens (human)Potency23.710111
caspase-3Homo sapiens (human)Potency23.710111
Cellular tumor antigen p53Homo sapiens (human)Potency18.195125
Chain A, HADH2 proteinHomo sapiens (human)Potency39.810711
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency7.943311
Chain B, HADH2 proteinHomo sapiens (human)Potency39.810711
chromobox protein homolog 1Homo sapiens (human)Potency79.432811
cytochrome P450 2C9, partialHomo sapiens (human)Potency14.116112
cytochrome P450 2D6Homo sapiens (human)Potency9.663212
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency3.283413
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency8.374514
estrogen nuclear receptor alphaHomo sapiens (human)Potency18.28961139
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency4.6234315
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency34.2014832
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency1.995311
farnesoid X nuclear receptorHomo sapiens (human)Potency27.016437
GVesicular stomatitis virusPotency14.116112
GALC proteinHomo sapiens (human)Potency0.707911
gemininHomo sapiens (human)Potency10.197323
GLI family zinc finger 3Homo sapiens (human)Potency17.8273214
glucocerebrosidaseHomo sapiens (human)Potency14.987212
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency6.1737413
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency47.108913
heat shock protein beta-1Homo sapiens (human)Potency31.460124
Histone H2A.xCricetulus griseus (Chinese hamster)Potency72.569425
HLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)Potency14.116112
hypoxia-inducible factor 1 alpha subunitHomo sapiens (human)Potency26.832522
Inositol hexakisphosphate kinase 1Homo sapiens (human)Potency14.116114
Interferon betaHomo sapiens (human)Potency20.508723
lethal factor (plasmid)Bacillus anthracis str. A2012Potency31.622811
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency38.8034312
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_aHomo sapiens (human)Potency53.350613
Nuclear receptor ROR-gammaHomo sapiens (human)Potency23.317412
nuclear receptor subfamily 1, group I, member 2Rattus norvegicus (Norway rat)Potency14.125411
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency37.397425
peripheral myelin protein 22Rattus norvegicus (Norway rat)Potency9.074311
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency24.233456
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency29.178258
plasminogen precursorMus musculus (house mouse)Potency12.589311
pregnane X nuclear receptorHomo sapiens (human)Potency33.358337
pregnane X receptorRattus norvegicus (Norway rat)Potency36.253012
progesterone receptorHomo sapiens (human)Potency10.6039317
RAR-related orphan receptor gammaMus musculus (house mouse)Potency24.384528
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency34.5971314
retinoid X nuclear receptor alphaHomo sapiens (human)Potency27.003428
SMAD family member 2Homo sapiens (human)Potency26.936922
SMAD family member 3Homo sapiens (human)Potency26.936922
Smad3Homo sapiens (human)Potency3.981111
Spike glycoproteinSevere acute respiratory syndrome-related coronavirusPotency35.481311
TAR DNA-binding protein 43Homo sapiens (human)Potency35.481311
TDP1 proteinHomo sapiens (human)Potency16.121029
thioredoxin reductaseRattus norvegicus (Norway rat)Potency70.794611
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency21.548129
thyroid hormone receptor beta isoform aHomo sapiens (human)Potency0.891311
thyroid stimulating hormone receptorHomo sapiens (human)Potency27.244644
transcriptional regulator ERG isoform 3Homo sapiens (human)Potency1.756012
urokinase plasminogen activator surface receptor precursorMus musculus (house mouse)Potency12.589311
urokinase-type plasminogen activator precursorMus musculus (house mouse)Potency12.589311
USP1 protein, partialHomo sapiens (human)Potency6.309611
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency29.983428
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency15.737535
Voltage-dependent calcium channel gamma-2 subunitMus musculus (house mouse)Potency47.108913

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
AcetylcholinesteraseHomo sapiens (human)IC506.504011
Adenosine receptor A3Homo sapiens (human)IC508.325011
Adenosine receptor A3Homo sapiens (human)Ki4.705011
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)IC502.098011
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)Ki2.080011
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)IC508.325011
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)Ki4.705011
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)IC508.325011
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)Ki4.705011
Androgen receptorHomo sapiens (human)IC505.000422
Androgen receptorRattus norvegicus (Norway rat)IC500.012336
Androgen receptorHomo sapiens (human)Ki0.024533
Androgen receptorRattus norvegicus (Norway rat)Ki0.007835
Cytochrome P450 2C19Homo sapiens (human)IC500.669412
Cytochrome P450 2C9 Homo sapiens (human)IC501.127611
Cytochrome P450 2D6Homo sapiens (human)IC509.274011
Estrogen receptorHomo sapiens (human)IC500.617012
Estrogen receptorHomo sapiens (human)Ki0.176012
Glucocorticoid receptorHomo sapiens (human)IC501.843011
Glucocorticoid receptorHomo sapiens (human)Ki0.838011
Glycine receptor subunit alpha-1Rattus norvegicus (Norway rat)IC501.843011
Glycine receptor subunit alpha-1Rattus norvegicus (Norway rat)Ki0.838011
Glycine receptor subunit alpha-2Rattus norvegicus (Norway rat)IC501.843011
Glycine receptor subunit alpha-2Rattus norvegicus (Norway rat)Ki0.838011
Glycine receptor subunit alpha-3Rattus norvegicus (Norway rat)IC501.843011
Glycine receptor subunit alpha-3Rattus norvegicus (Norway rat)Ki0.838011
Glycine receptor subunit betaRattus norvegicus (Norway rat)IC501.843011
Glycine receptor subunit betaRattus norvegicus (Norway rat)Ki0.838011
Muscarinic acetylcholine receptor M2Homo sapiens (human)IC500.292011
Muscarinic acetylcholine receptor M2Homo sapiens (human)Ki0.104011
Sodium-dependent noradrenaline transporter Homo sapiens (human)IC502.098011
Sodium-dependent noradrenaline transporter Homo sapiens (human)Ki2.080011
Sodium-dependent serotonin transporterHomo sapiens (human)IC500.081011
Sodium-dependent serotonin transporterHomo sapiens (human)Ki0.043011

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Androgen receptorHomo sapiens (human)EC500.000311
Sex hormone-binding globulinHomo sapiens (human)Kd0.003711