Shaken Baby Syndrome

Brain injuries resulted from vigorous shaking of an infant or young child held by the chest, shoulders, or extremities causing extreme cranial acceleration. It is characterized by the intracranial and intraocular hemorrhages with no evident external trauma. Serious cases may result in death.

Synonyms(1)

Synonym
Shaken Baby Syndrome

Research Excerpts

Overview

Excerpt	Reference
"Shaken baby syndrome is one of the most common causes of disability and death in infants younger than one year of age."	( Banschak, S; Bartschat, S; Richter, C; Stiller, D, 2016)

Research

Studies (23)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	1 (4.35)	12.5806
2000's	12 (52.17)	18.1394
2010's	9 (39.13)	28.8240
2020's	1 (4.35)	9.53

Drug	Relationship Strength	Studies
glutaric acid	low	1
histamine	low	1
amantadine	low	1
amitriptyline	low	1
apnea	low	2
propranolol	low	1
perflutren	low	1
gadolinium	low	1
4-methoxyamphetamine	low	2
glutamic acid	low	1
propiconazole	low	3
3-hydroxyglutaric acid	low	1
vitamin k semiquinone radical	low	1
vitamin k 1	low	1
dizocilpine maleate	low	1
ascorbic acid	low	1
agar	low	1
exudates	low	1
eye	low	5

Protein Targets (374)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Solute carrier family 22 member 6	0	2	0	3
5-hydroxytryptamine receptor 2C	0	2	1	3
5-hydroxytryptamine receptor 2A	0	2	1	3
5-hydroxytryptamine receptor 1A	0	5	2	8
5-hydroxytryptamine receptor 1B	0	5	1	6
5-hydroxytryptamine receptor 1D	0	2	1	3
5-hydroxytryptamine receptor 1F	0	2	1	3
5-hydroxytryptamine receptor 2B	0	2	1	3
5-hydroxytryptamine receptor 6	0	1	1	2
Sodium-dependent serotonin transporter	0	4	1	5
Sodium-dependent serotonin transporter	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	1	2
5-hydroxytryptamine receptor 5A	0	1	1	2
5-hydroxytryptamine receptor 5B	0	1	1	2
5-hydroxytryptamine receptor 3A	0	1	1	2
5-hydroxytryptamine receptor 4	0	1	1	2
5-hydroxytryptamine receptor 3B	0	1	1	2
acetylcholinesterase	3	0	0	3
thioredoxin reductase	7	0	0	7
RAR-related orphan receptor gamma	5	0	0	5
NFKB1 protein, partial	2	0	0	2
GLI family zinc finger 3	3	0	0	3
AR protein	5	0	0	5
signal transducer and activator of transcription 6, interleukin-4 induced	1	0	0	1
thyroid stimulating hormone receptor	2	0	0	2
regulator of G-protein signaling 4	3	0	0	3
EWS/FLI fusion protein	2	0	0	2
estrogen nuclear receptor alpha	5	0	0	5
putative alpha-glucosidase	1	0	0	1
euchromatic histone-lysine N-methyltransferase 2	8	0	0	8
thyroid hormone receptor beta isoform 2	7	0	0	7
heat shock protein beta-1	1	0	0	1
peripheral myelin protein 22	2	0	0	2
histone acetyltransferase KAT2A isoform 1	2	0	0	2
lamin isoform A-delta10	4	0	0	4
Solute carrier family 22 member 2	0	1	0	3
Solute carrier family 22 member 1	0	2	0	4
Glutamate receptor ionotropic, NMDA 2D	0	2	0	2
Glutamate receptor ionotropic, NMDA 3B	0	2	0	2
Matrix protein 2	0	1	1	2
Matrix protein 2	0	1	2	3
Glutamate receptor ionotropic, NMDA 1	0	4	1	6
Spike glycoprotein	2	0	0	2
Glutamate receptor ionotropic, NMDA 2A	0	4	1	6
Glutamate receptor ionotropic, NMDA 2B	0	4	1	6
Glutamate receptor ionotropic, NMDA 2C	0	4	1	6
Glutamate receptor ionotropic, NMDA 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	2	0	2
Glutamate receptor ionotropic, NMDA 2C	0	2	0	2
Glutamate receptor ionotropic, NMDA 2D	0	4	1	6
Solute carrier family 22 member 1	0	2	0	3
Glutamate receptor ionotropic, NMDA 3A	0	2	0	2
Glutamate receptor ionotropic, NMDA 3B	0	4	1	6
Multidrug and toxin extrusion protein 1	0	1	0	1
Solute carrier family 22 member 2	0	2	0	3
Glutamate receptor ionotropic, NMDA 3A	0	4	1	6
ATP-dependent phosphofructokinase	1	0	0	1
Chain A, HADH2 protein	1	0	0	1
Chain B, HADH2 protein	1	0	0	1
USP1 protein, partial	3	0	0	3
GLS protein	3	0	0	3
cytochrome P450 family 3 subfamily A polypeptide 4	3	0	0	3
cytochrome P450 2D6	1	0	0	1
arylsulfatase A	3	0	0	3
cytochrome P450 2D6 isoform 1	1	0	0	1
D(1A) dopamine receptor	3	0	0	3
chromobox protein homolog 1	4	0	0	4
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
serine/threonine-protein kinase mTOR isoform 1	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 1	3	0	0	3
muscarinic acetylcholine receptor M1	1	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	2	0	0	2
ATP-binding cassette sub-family C member 3	0	2	0	2
Multidrug resistance-associated protein 4	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
5-hydroxytryptamine receptor 4	0	4	0	4
Bile salt export pump	0	4	0	4
Albumin	0	0	1	1
High affinity nerve growth factor receptor	0	1	2	3
Aldo-keto reductase family 1 member B1	0	2	0	2
Muscarinic acetylcholine receptor M2	0	3	1	4
Muscarinic acetylcholine receptor M4	0	2	0	2
Muscarinic acetylcholine receptor M1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	1	0	1
Muscarinic acetylcholine receptor M4	0	1	0	1
Muscarinic acetylcholine receptor M5	0	1	0	1
Muscarinic acetylcholine receptor M5	0	2	0	2
Alpha-2A adrenergic receptor	0	3	2	6
Muscarinic acetylcholine receptor M2	0	1	0	1
Muscarinic acetylcholine receptor M1	0	3	1	4
Angiotensin-converting enzyme	0	2	0	2
D(2) dopamine receptor	0	3	1	4
Alpha-2B adrenergic receptor	0	2	2	5
Alpha-2C adrenergic receptor	0	3	2	6
Muscarinic acetylcholine receptor M3	0	3	1	4
D(1A) dopamine receptor	0	3	1	4
D(1B) dopamine receptor	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	0	0	1
Sodium-dependent noradrenaline transporter	0	2	0	2
Histamine H2 receptor	0	3	2	5
Alpha-1D adrenergic receptor	0	2	1	4
5-hydroxytryptamine receptor 2A	0	4	1	5
5-hydroxytryptamine receptor 2C	0	4	1	5
Histamine H1 receptor	0	3	1	4
Histamine H1 receptor	0	4	2	6
D(3) dopamine receptor	0	2	0	2
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	1	0	1
UDP-glucuronosyltransferase 1A3	0	0	0	1
5-hydroxytryptamine receptor 2B	0	4	1	5
Alpha-1A adrenergic receptor	0	2	1	3
Histamine H2 receptor	2	1	1	5
D(1A) dopamine receptor	1	0	0	1
5-hydroxytryptamine receptor 6	0	4	1	5
5-hydroxytryptamine receptor 7	0	2	0	2
Voltage-dependent N-type calcium channel subunit alpha-1B	0	1	0	1
Sodium channel protein type 7 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Sodium-dependent dopamine transporter	0	2	0	2
Potassium voltage-gated channel subfamily H member 2	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Sodium channel protein type 5 subunit alpha	0	2	0	2
Sodium channel protein type 9 subunit alpha	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	0	1	1
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Canalicular multispecific organic anion transporter 1	0	2	0	2
Sodium channel protein type 2 subunit alpha	0	1	0	1
Ataxin-2	3	0	0	3
Sigma non-opioid intracellular receptor 1	0	4	0	4
Sodium channel protein type 3 subunit alpha	0	1	0	1
Sodium channel protein type 11 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Histamine H3 receptor	0	2	2	4
Sodium channel protein type 10 subunit alpha	0	1	0	1
ATAD5 protein, partial	1	0	0	1
TDP1 protein	6	0	0	6
Microtubule-associated protein tau	1	0	0	1
estrogen-related nuclear receptor alpha	4	0	0	4
Bloom syndrome protein isoform 1	1	0	0	1
neuropeptide S receptor isoform A	1	0	0	1
Chain A, Hyaluronidase, phage associated	0	1	0	1
thioredoxin glutathione reductase	2	0	0	2
glucocorticoid receptor [Homo sapiens]	3	0	0	3
retinoic acid nuclear receptor alpha variant 1	4	0	0	4
vitamin D (1,25- dihydroxyvitamin D3) receptor	1	0	0	1
IDH1	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 2	1	0	0	1
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
geminin	4	0	0	4
lethal factor (plasmid)	1	0	0	1
Polyphenol oxidase 2	0	1	0	1
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	1	0	1
Urease	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	1	0	1
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	2	0	0	2
DNA polymerase iota isoform a (long)	5	0	0	5
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
glp-1 receptor, partial	2	0	0	2
phosphopantetheinyl transferase	3	0	0	3
beta-2 adrenergic receptor	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	1	0	0	1
Metabotropic glutamate receptor 8	0	2	0	2
Metabotropic glutamate receptor 6	0	1	1	3
Excitatory amino acid transporter 4	0	1	0	1
Glutathione reductase, mitochondrial	0	2	0	2
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
Prothrombin	0	0	1	1
Carbonic anhydrase 1	0	0	0	2
Carbonic anhydrase 2	0	0	0	3
Integrin beta-3	0	0	1	1
Integrin alpha-IIb	0	0	1	1
ATP-citrate synthase	0	1	0	1
Glutamate receptor 1	0	2	1	3
Glutamate receptor 2	1	2	1	4
Glutamate receptor 3	0	2	1	3
Glutamate receptor 4	0	2	1	3
Glutamate receptor ionotropic, kainate 1	0	2	1	3
Metabotropic glutamate receptor 1	0	1	1	2
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 5	0	1	2	3
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Glutamate receptor ionotropic, kainate 1	0	1	1	2
Metabotropic glutamate receptor 5	0	1	1	3
Glutamate receptor ionotropic, kainate 2	0	2	1	3
Glutamate receptor 1	0	2	1	3
Glutamate receptor 2	0	2	1	3
Glutamate receptor 3	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	2	0	2
Excitatory amino acid transporter 1	0	2	0	3
Excitatory amino acid transporter 2	0	2	0	3
Excitatory amino acid transporter 3	0	2	0	3
Metabotropic glutamate receptor 8	0	0	1	1
Glutamate receptor 4	0	2	1	3
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Fatty-acid amide hydrolase 1	0	1	0	1
Glutamate receptor ionotropic, kainate 4	0	2	0	2
Glutamate carboxypeptidase 2	0	1	0	1
Glutamate receptor ionotropic, kainate 2	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Metabotropic glutamate receptor 1	0	1	1	3
Metabotropic glutamate receptor 2	0	1	1	3
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate receptor ionotropic, kainate 5	0	1	0	1
Carbonic anhydrase-like protein, putative	0	0	0	2
Glutamate receptor ionotropic, kainate 5	0	2	0	2
Glutamate racemase	0	0	0	1
Prolyl 4-hydroxylase	0	1	0	1
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Chain A, Protein (aspartate Aminotransferase)	0	0	1	1
Chain A, Aspartate Aminotransferase	0	0	1	1
estrogen receptor 2 (ER beta)	2	0	0	2
nuclear receptor subfamily 1, group I, member 3	2	0	0	2
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	1	0	0	1
Chain A, Protein (female-specific Histamine Binding Protein 2)	0	0	1	1
Chain A, Beta-lactamase	3	0	0	3
aryl hydrocarbon receptor nuclear translocator	0	0	0	1
GALC protein	1	0	0	1
apical membrane antigen 1, AMA1	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	1	0	0	1
transforming acidic coiled-coil-containing protein 3	0	0	0	1
Carbonic anhydrase 12	0	0	0	1
Solute carrier family 22 member 3	0	1	0	2
Plasma kallikrein	0	0	0	1
Carbonic anhydrase 3	0	0	0	1
Macrophage migration inhibitory factor	0	2	0	2
Carbonic anhydrase 4	0	0	0	1
Carbonic anhydrase 6	0	0	0	1
Adenosine receptor A1	0	0	0	1
5-hydroxytryptamine receptor 1D	0	0	0	1
Adenosine receptor A2a	0	0	0	1
Histamine H1 receptor	0	1	2	3
Carbonic anhydrase 5A, mitochondrial	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase 7	0	0	0	1
Carbonic anhydrase	0	0	0	2
Histamine H3 receptor	0	1	0	1
Histamine N-methyltransferase	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase 9	0	0	0	1
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	0	0	2
Equilibrative nucleoside transporter 4	0	0	0	1
Carbonic anhydrase 13	0	0	0	1
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	0	1
Carbonic anhydrase 4	0	0	0	1
Carbonic anhydrase 15	0	0	0	1
Carbonic anhydrase 13	0	0	0	1
Histamine H4 receptor	0	1	2	3
Histamine H3 receptor	0	1	0	1
Carboxylic ester hydrolase	0	0	0	1
Carbonic anhydrase 14	0	0	0	1
Carbonic anhydrase 5B, mitochondrial	0	0	0	1
Chain A, Ferritin light chain	2	0	0	2
pregnane X receptor	1	0	0	1
SMAD family member 2	1	0	0	1
SMAD family member 3	1	0	0	1
progesterone receptor	1	0	0	1
nonstructural protein 1	1	0	0	1
retinoid X nuclear receptor alpha	1	0	0	1
farnesoid X nuclear receptor	1	0	0	1
pregnane X nuclear receptor	1	0	0	1
peroxisome proliferator-activated receptor delta	1	0	0	1
peroxisome proliferator activated receptor gamma	1	0	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
aryl hydrocarbon receptor	2	0	0	2
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	1	0	0	1
vitamin D3 receptor isoform VDRA	2	0	0	2
thyroid hormone receptor beta isoform a	1	0	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
nuclear receptor ROR-gamma isoform 1	1	0	0	1
Voltage-dependent calcium channel gamma-2 subunit	1	0	0	1
Cellular tumor antigen p53	2	0	0	2
Cytochrome P450 3A4	0	2	0	2
Guanine nucleotide-binding protein G	1	0	0	1
TAR DNA-binding protein 43	1	0	0	1
ATPase family AAA domain-containing protein 5	1	0	0	1
heat shock protein 90, putative	0	0	0	1
Beta-1 adrenergic receptor	0	1	1	3
Gamma-aminobutyric acid receptor subunit pi	0	1	1	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Bile salt export pump	0	1	0	1
Albumin	0	0	1	1
Cytochrome P450 1A2	0	1	0	1
Beta-2 adrenergic receptor	0	2	1	3
ATP-dependent translocase ABCB1	0	2	0	2
Beta-1 adrenergic receptor	0	2	1	3
5-hydroxytryptamine receptor 1A	0	1	0	1
Adenosine receptor A3	0	1	1	2
Beta-2 adrenergic receptor	0	2	0	3
Cytochrome P450 2C8	0	1	0	1
Cytochrome P450 2D6	0	1	0	1
Cytochrome P450 2C9	0	1	0	1
Beta-3 adrenergic receptor	0	2	1	3
Gamma-aminobutyric acid receptor subunit beta-1	0	1	1	2
Alpha-1B adrenergic receptor	0	1	1	2
Beta-1 adrenergic receptor	0	2	1	4
Gamma-aminobutyric acid receptor subunit delta	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	1	2
D(3) dopamine receptor	0	1	0	1
Alpha-2B adrenergic receptor	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	1	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Alpha-2C adrenergic receptor	0	0	1	1
Alpha-2A adrenergic receptor	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	1	2
Alpha-1D adrenergic receptor	0	1	1	2
Endothelin-1 receptor	0	1	1	2
Beta-3 adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 1B	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	1	2
Adenosine receptor A2a	0	1	1	2
Neuromedin-K receptor	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	1	2
Type-1 angiotensin II receptor	0	1	1	2
Cholecystokinin receptor type A	0	1	1	2
Cytochrome P450 2C19	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	1	2
Beta-1 adrenergic receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	1	2	4
Alpha-1B adrenergic receptor	0	0	1	2
Mu-type opioid receptor	0	1	1	2
Vasopressin V1a receptor	0	1	1	2
Delta-type opioid receptor	0	1	1	2
Kappa-type opioid receptor	0	1	1	2
Cytochrome P450 2J2	0	1	0	1
Beta-2 adrenergic receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-2	0	1	1	2
Sodium/bile acid cotransporter	0	1	0	1
Beta-2 adrenergic receptor	0	1	1	3
GABA theta subunit	0	1	1	2
Gamma-aminobutyric acid receptor subunit epsilon	0	1	1	2
Nuclear receptor subfamily 2 group E member 1	0	0	2	2
G	1	0	0	1
DNA polymerase eta isoform 1	1	0	0	1
Rap guanine nucleotide exchange factor 3	2	0	0	2
Interferon beta	1	0	0	1
HLA class I histocompatibility antigen, B alpha chain	1	0	0	1
Alpha-synuclein	0	1	0	1
Inositol hexakisphosphate kinase 1	1	0	0	1
cytochrome P450 2C9, partial	1	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

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