Page last updated: 2024-09-27

Shaken Baby Syndrome

Brain injuries resulted from vigorous shaking of an infant or young child held by the chest, shoulders, or extremities causing extreme cranial acceleration. It is characterized by the intracranial and intraocular hemorrhages with no evident external trauma. Serious cases may result in death.

Synonyms(1)

Synonym
Shaken Baby Syndrome

Research Excerpts

Overview

ExcerptReference
"Shaken baby syndrome is one of the most common causes of disability and death in infants younger than one year of age."( Banschak, S; Bartschat, S; Richter, C; Stiller, D, 2016)

Research

Studies (23)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's1 (4.35)12.5806
2000's12 (52.17)18.1394
2010's9 (39.13)28.8240
2020's1 (4.35)9.53
DrugIndicatedRelationship StrengthStudiesTrials
glutaric acid0low10
histamine0low10
amantadine0low10
amitriptyline0low10
apnea0low20
propranolol0low10
perflutren0low10
gadolinium0low10
4-methoxyamphetamine0low20
glutamic acid0low10
propiconazole0low30
3-hydroxyglutaric acid0low10
vitamin k semiquinone radical0low10
vitamin k 10low10
dizocilpine maleate0low10
ascorbic acid0low10
agar0low10
exudates0low10
eye0low50

Protein Targets (374)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Solute carrier family 22 member 60203
5-hydroxytryptamine receptor 2C0213
5-hydroxytryptamine receptor 2A0213
5-hydroxytryptamine receptor 1A0528
5-hydroxytryptamine receptor 1B0516
5-hydroxytryptamine receptor 1D0213
5-hydroxytryptamine receptor 1F0213
5-hydroxytryptamine receptor 2B0213
5-hydroxytryptamine receptor 60112
Sodium-dependent serotonin transporter0415
Sodium-dependent serotonin transporter0101
5-hydroxytryptamine receptor 7 0112
5-hydroxytryptamine receptor 5A0112
5-hydroxytryptamine receptor 5B0112
5-hydroxytryptamine receptor 3A0112
5-hydroxytryptamine receptor 4 0112
5-hydroxytryptamine receptor 3B0112
acetylcholinesterase3003
thioredoxin reductase7007
RAR-related orphan receptor gamma5005
NFKB1 protein, partial2002
GLI family zinc finger 33003
AR protein5005
signal transducer and activator of transcription 6, interleukin-4 induced1001
thyroid stimulating hormone receptor2002
regulator of G-protein signaling 43003
EWS/FLI fusion protein2002
estrogen nuclear receptor alpha5005
putative alpha-glucosidase1001
euchromatic histone-lysine N-methyltransferase 28008
thyroid hormone receptor beta isoform 27007
heat shock protein beta-11001
peripheral myelin protein 222002
histone acetyltransferase KAT2A isoform 12002
lamin isoform A-delta104004
Solute carrier family 22 member 20103
Solute carrier family 22 member 1 0204
Glutamate receptor ionotropic, NMDA 2D0202
Glutamate receptor ionotropic, NMDA 3B0202
Matrix protein 20112
Matrix protein 20123
Glutamate receptor ionotropic, NMDA 1 0416
Spike glycoprotein2002
Glutamate receptor ionotropic, NMDA 2A 0416
Glutamate receptor ionotropic, NMDA 2B0416
Glutamate receptor ionotropic, NMDA 2C0416
Glutamate receptor ionotropic, NMDA 10202
Glutamate receptor ionotropic, NMDA 2A0202
Glutamate receptor ionotropic, NMDA 2B0202
Glutamate receptor ionotropic, NMDA 2C0202
Glutamate receptor ionotropic, NMDA 2D0416
Solute carrier family 22 member 10203
Glutamate receptor ionotropic, NMDA 3A0202
Glutamate receptor ionotropic, NMDA 3B0416
Multidrug and toxin extrusion protein 10101
Solute carrier family 22 member 20203
Glutamate receptor ionotropic, NMDA 3A0416
ATP-dependent phosphofructokinase1001
Chain A, HADH2 protein1001
Chain B, HADH2 protein1001
USP1 protein, partial3003
GLS protein3003
cytochrome P450 family 3 subfamily A polypeptide 43003
cytochrome P450 2D61001
arylsulfatase A3003
cytochrome P450 2D6 isoform 11001
D(1A) dopamine receptor3003
chromobox protein homolog 14004
atrial natriuretic peptide receptor 2 precursor1001
serine/threonine-protein kinase mTOR isoform 11001
nuclear factor erythroid 2-related factor 2 isoform 13003
muscarinic acetylcholine receptor M11001
Polyunsaturated fatty acid lipoxygenase ALOX15B2002
ATP-binding cassette sub-family C member 30202
Multidrug resistance-associated protein 40202
Voltage-dependent L-type calcium channel subunit alpha-1F0101
5-hydroxytryptamine receptor 40404
Bile salt export pump0404
Albumin0011
High affinity nerve growth factor receptor0123
Aldo-keto reductase family 1 member B10202
Muscarinic acetylcholine receptor M20314
Muscarinic acetylcholine receptor M40202
Muscarinic acetylcholine receptor M10101
Muscarinic acetylcholine receptor M30101
Muscarinic acetylcholine receptor M40101
Muscarinic acetylcholine receptor M50101
Muscarinic acetylcholine receptor M50202
Alpha-2A adrenergic receptor0326
Muscarinic acetylcholine receptor M20101
Muscarinic acetylcholine receptor M10314
Angiotensin-converting enzyme0202
D(2) dopamine receptor0314
Alpha-2B adrenergic receptor0225
Alpha-2C adrenergic receptor0326
Muscarinic acetylcholine receptor M30314
D(1A) dopamine receptor0314
D(1B) dopamine receptor0101
UDP-glucuronosyltransferase 1A40001
Sodium-dependent noradrenaline transporter 0202
Histamine H2 receptor0325
Alpha-1D adrenergic receptor0214
5-hydroxytryptamine receptor 2A0415
5-hydroxytryptamine receptor 2C0415
Histamine H1 receptor0314
Histamine H1 receptor0426
D(3) dopamine receptor0202
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 4 subunit alpha0101
UDP-glucuronosyltransferase 1A30001
5-hydroxytryptamine receptor 2B0415
Alpha-1A adrenergic receptor0213
Histamine H2 receptor2115
D(1A) dopamine receptor1001
5-hydroxytryptamine receptor 60415
5-hydroxytryptamine receptor 70202
Voltage-dependent N-type calcium channel subunit alpha-1B0101
Sodium channel protein type 7 subunit alpha0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
Sodium-dependent dopamine transporter 0202
Potassium voltage-gated channel subfamily H member 20303
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1C0202
Sodium channel protein type 5 subunit alpha0202
Sodium channel protein type 9 subunit alpha0101
Sigma non-opioid intracellular receptor 10011
Nuclear receptor subfamily 3 group C member 3 0202
Canalicular multispecific organic anion transporter 10202
Sodium channel protein type 2 subunit alpha0101
Ataxin-23003
Sigma non-opioid intracellular receptor 10404
Sodium channel protein type 3 subunit alpha0101
Sodium channel protein type 11 subunit alpha0101
Sodium channel protein type 8 subunit alpha0101
Histamine H3 receptor0224
Sodium channel protein type 10 subunit alpha0101
ATAD5 protein, partial1001
TDP1 protein6006
Microtubule-associated protein tau1001
estrogen-related nuclear receptor alpha4004
Bloom syndrome protein isoform 11001
neuropeptide S receptor isoform A1001
Chain A, Hyaluronidase, phage associated0101
thioredoxin glutathione reductase2002
glucocorticoid receptor [Homo sapiens]3003
retinoic acid nuclear receptor alpha variant 14004
vitamin D (1,25- dihydroxyvitamin D3) receptor1001
IDH11001
nuclear factor erythroid 2-related factor 2 isoform 21001
lethal(3)malignant brain tumor-like protein 1 isoform I1001
geminin4004
lethal factor (plasmid)1001
Polyphenol oxidase 20101
Pancreatic alpha-amylase0202
Albumin0101
Urease0101
Prolyl 4-hydroxylase subunit alpha-10001
Tyrosinase0101
Hyaluronate lyase0101
Prolyl hydroxylase EGLN20001
Egl nine homolog 10001
Prolyl hydroxylase EGLN30001
Hypoxia-inducible factor 1-alpha inhibitor0001
Solute carrier family 23 member 10101
potassium voltage-gated channel subfamily H member 2 isoform d2002
DNA polymerase iota isoform a (long)5005
Chain A, GLUTAMATE RECEPTOR SUBUNIT 20101
Chain A, Glutamate Receptor Subunit 20101
Chain B, Glutamate Receptor Subunit 20101
Chain A, Slr1257 protein0011
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]0101
glp-1 receptor, partial2002
phosphopantetheinyl transferase3003
beta-2 adrenergic receptor1001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
Metabotropic glutamate receptor 80202
Metabotropic glutamate receptor 60113
Excitatory amino acid transporter 40101
Glutathione reductase, mitochondrial0202
Bifunctional aspartokinase/homoserine dehydrogenase 10101
Prothrombin0011
Carbonic anhydrase 10002
Carbonic anhydrase 20003
Integrin beta-30011
Integrin alpha-IIb0011
ATP-citrate synthase 0101
Glutamate receptor 10213
Glutamate receptor 21214
Glutamate receptor 30213
Glutamate receptor 40213
Glutamate receptor ionotropic, kainate 10213
Metabotropic glutamate receptor 10112
Metabotropic glutamate receptor 20011
Metabotropic glutamate receptor 30011
Metabotropic glutamate receptor 40112
Metabotropic glutamate receptor 50123
Metabotropic glutamate receptor 60011
Metabotropic glutamate receptor 70011
Glutamate receptor ionotropic, kainate 10112
Metabotropic glutamate receptor 50113
Glutamate receptor ionotropic, kainate 20213
Glutamate receptor 10213
Glutamate receptor 20213
Glutamate receptor 30112
Glutamate receptor ionotropic, kainate 30202
Excitatory amino acid transporter 10203
Excitatory amino acid transporter 20203
Excitatory amino acid transporter 30203
Metabotropic glutamate receptor 80011
Glutamate receptor 40213
Excitatory amino acid transporter 3 0001
Glutamate racemase0001
Metabotropic glutamate receptor 80112
Fatty-acid amide hydrolase 10101
Glutamate receptor ionotropic, kainate 40202
Glutamate carboxypeptidase 20101
Glutamate receptor ionotropic, kainate 20112
Glutamate receptor ionotropic, kainate 30101
Metabotropic glutamate receptor 10113
Metabotropic glutamate receptor 20113
Metabotropic glutamate receptor 70113
Metabotropic glutamate receptor 30113
Metabotropic glutamate receptor 40113
Glutamate receptor ionotropic, kainate 50101
Carbonic anhydrase-like protein, putative0002
Glutamate receptor ionotropic, kainate 50202
Glutamate racemase0001
Prolyl 4-hydroxylase0101
Alpha-ketoglutarate-dependent dioxygenase FTO0101
Chain A, Protein (aspartate Aminotransferase)0011
Chain A, Aspartate Aminotransferase0011
estrogen receptor 2 (ER beta)2002
nuclear receptor subfamily 1, group I, member 32002
Solute carrier family 22 member 200101
Solute carrier family 22 member 60101
Solute carrier family 22 member 70001
Chain A, CARBONIC ANHYDRASE II0011
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE1001
Chain A, Protein (female-specific Histamine Binding Protein 2)0011
Chain A, Beta-lactamase3003
aryl hydrocarbon receptor nuclear translocator0001
GALC protein1001
apical membrane antigen 1, AMA11001
bromodomain adjacent to zinc finger domain 2B1001
transforming acidic coiled-coil-containing protein 30001
Carbonic anhydrase 120001
Solute carrier family 22 member 30102
Plasma kallikrein0001
Carbonic anhydrase 30001
Macrophage migration inhibitory factor0202
Carbonic anhydrase 40001
Carbonic anhydrase 60001
Adenosine receptor A10001
5-hydroxytryptamine receptor 1D0001
Adenosine receptor A2a0001
Histamine H1 receptor0123
Carbonic anhydrase 5A, mitochondrial0001
Carbonic anhydrase0001
Carbonic anhydrase 70001
Carbonic anhydrase0002
Histamine H3 receptor0101
Histamine N-methyltransferase 0101
Glutaminyl-peptide cyclotransferase0101
Carbonic anhydrase 90001
Carbonic anhydrase 0002
Carbonic anhydrase0002
Carbonic anhydrase0002
Carbonic anhydrase 0002
Equilibrative nucleoside transporter 40001
Carbonic anhydrase 130001
Histamine H4 receptor0123
Histamine H4 receptor0123
Histamine H4 receptor 0101
Carbonic anhydrase 40001
Carbonic anhydrase 150001
Carbonic anhydrase 130001
Histamine H4 receptor0123
Histamine H3 receptor0101
Carboxylic ester hydrolase 0001
Carbonic anhydrase 140001
Carbonic anhydrase 5B, mitochondrial0001
Chain A, Ferritin light chain2002
pregnane X receptor1001
SMAD family member 21001
SMAD family member 31001
progesterone receptor1001
nonstructural protein 11001
retinoid X nuclear receptor alpha1001
farnesoid X nuclear receptor1001
pregnane X nuclear receptor1001
peroxisome proliferator-activated receptor delta1001
peroxisome proliferator activated receptor gamma1001
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
aryl hydrocarbon receptor2002
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a1001
vitamin D3 receptor isoform VDRA2002
thyroid hormone receptor beta isoform a1001
heat shock protein HSP 90-alpha isoform 20001
nuclear receptor ROR-gamma isoform 11001
Voltage-dependent calcium channel gamma-2 subunit1001
Cellular tumor antigen p532002
Cytochrome P450 3A40202
Guanine nucleotide-binding protein G1001
TAR DNA-binding protein 431001
ATPase family AAA domain-containing protein 51001
heat shock protein 90, putative0001
Beta-1 adrenergic receptor 0113
Gamma-aminobutyric acid receptor subunit pi0112
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Bile salt export pump0101
Albumin0011
Cytochrome P450 1A20101
Beta-2 adrenergic receptor0213
ATP-dependent translocase ABCB10202
Beta-1 adrenergic receptor0213
5-hydroxytryptamine receptor 1A0101
Adenosine receptor A30112
Beta-2 adrenergic receptor0203
Cytochrome P450 2C80101
Cytochrome P450 2D60101
Cytochrome P450 2C9 0101
Beta-3 adrenergic receptor0213
Gamma-aminobutyric acid receptor subunit beta-10112
Alpha-1B adrenergic receptor0112
Beta-1 adrenergic receptor0214
Gamma-aminobutyric acid receptor subunit delta0112
Gamma-aminobutyric acid receptor subunit gamma-20112
D(3) dopamine receptor0101
Alpha-2B adrenergic receptor0011
Gamma-aminobutyric acid receptor subunit alpha-50112
Gamma-aminobutyric acid receptor subunit alpha-30112
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Alpha-2C adrenergic receptor0011
Alpha-2A adrenergic receptor0011
Gamma-aminobutyric acid receptor subunit gamma-10112
Gamma-aminobutyric acid receptor subunit alpha-20112
Alpha-1D adrenergic receptor0112
Endothelin-1 receptor0112
Beta-3 adrenergic receptor0202
5-hydroxytryptamine receptor 1B0213
Gamma-aminobutyric acid receptor subunit alpha-40112
Gamma-aminobutyric acid receptor subunit gamma-30112
Adenosine receptor A2a0112
Neuromedin-K receptor0011
Gamma-aminobutyric acid receptor subunit alpha-60112
Type-1 angiotensin II receptor0112
Cholecystokinin receptor type A0112
Cytochrome P450 2C190101
5-hydroxytryptamine receptor 70112
Beta-1 adrenergic receptor0101
Alpha-1A adrenergic receptor0124
Alpha-1B adrenergic receptor0012
Mu-type opioid receptor0112
Vasopressin V1a receptor0112
Delta-type opioid receptor0112
Kappa-type opioid receptor0112
Cytochrome P450 2J20101
Beta-2 adrenergic receptor0101
Gamma-aminobutyric acid receptor subunit alpha-10112
Gamma-aminobutyric acid receptor subunit beta-30112
Gamma-aminobutyric acid receptor subunit beta-20112
Sodium/bile acid cotransporter0101
Beta-2 adrenergic receptor0113
GABA theta subunit0112
Gamma-aminobutyric acid receptor subunit epsilon0112
Nuclear receptor subfamily 2 group E member 10022
G1001
DNA polymerase eta isoform 11001
Rap guanine nucleotide exchange factor 32002
Interferon beta1001
HLA class I histocompatibility antigen, B alpha chain 1001
Alpha-synuclein0101
Inositol hexakisphosphate kinase 11001
cytochrome P450 2C9, partial1001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]