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EC 1.3.3.4 (protoporphyrinogen oxidase) inhibitor

An EC 1.3.3.* (oxidoreductase acting on donor CH-CH group with oxygen as acceptor) inhibitor that interferes with the action of protoporphyrinogen oxidase (EC 1.3.3.4).

ChEBI ID: 73192

Members (9)

MemberDefinitionClass
2,4,6-trichlorophenyl 4-nitrophenyl etherchlornitrofen
acifluorfenA member of the class of benzoic acids that is 2-nitrobenzoic acid in which the hydrogen at position 5 is replaced by a 2-chloro-4-(trifluoromethyl)phenoxy group. It is a herbicide used for the post-emergence control of a variety of annual broadleaf weeds.acifluorfen
aclonifenA primary amino compound that is aniline in which the phenyl group has been substituted at positions 2, 3, and 6 by chlorine, phenoxy, and nitro groups, respectively. A protoporphyrinogen oxidase (PPO) inhibitor, it is used as a herbicide against a broad range of weeds in a wide range of crops.aclonifen
butafenacilAn organofluorine compound that is 1-methyl-6-(trifluoromethyl)pyrimidine-2,4(1H,3H)-dione substituted by a 4-chloro-3-({[2-methyl-1-oxo-1-(prop-2-en-1-yloxy)propan-2-yl]oxy}carbonyl)phenyl group at position 3. It is a herbicide which inhibits the protoporphyrinogen-oxidase enzyme in plant chloroplasts, resulting in rapid knockdown of various broadleaf and grass weeds.butafenacil
fomesafenAn N-sulfonylcarboxamide that is N-(methylsulfonyl)benzamide in which the phenyl ring is substituted by a nitro group at position 2 and a 2-chloro-4-(trifluoromethyl)phenoxy group at position 5. A protoporphyrinogen oxidase inhibitor, it was specially developed for use (generally as the corresponding sodium salt, fomesafen-sodium) for post-emergence control of broad-leaf weeds in soya.fomesafen
n-(2,4-dichloro-5-(4-(difluoromethyl)-4,5-dihydro-3-methyl-5-oxo-1h-1,2,4-triazol-1-yl)phenyl)methanesulfonamideA member of the class of triazoles that is 5-oxo-1,2,4-triazole which is substituted at positions 1, 3, and 4 by 2,4-dichloro-5-[(methylsulfonyl)amino]phenyl, methyl, and difluoromethyl groups, respectively. A protoporphyrinogen oxidase inhibitor, it is used as a herbicide to control broad-leaved weeds in soya and tobacco crops. Not approved for use within the European Union.sulfentrazone
nitrofennitrofen
oxyfluorofenOxyfluorfen
s 53482A benzoxazine that is N-(prop-2-yn-1-yl)-2H-1,4-benzoxazin-3(4H)-one which is substituted at position 6 by a 1,3-dioxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl group and at position 7 by a fluorine. A protoporphyrinogen oxidase inhibitor, it is used for the control of weeds in soya, peanuts, and a variety of vegetable and fruit crops.flumioxazin

Research

Studies (34,681)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-199020,539 (59.22)18.7374
1990's5,208 (15.02)18.2507
2000's4,328 (12.48)29.6817
2010's3,540 (10.21)24.3611
2020's1,066 (3.07)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials1,081 (2.77%)5.53%
Reviews2,455 (6.28%)6.00%
Case Studies790 (2.02%)4.05%
Observational39 (0.10%)0.25%
Other34,725 (88.83%)84.16%

Protein Targets (48)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
acetylcholinesteraseHomo sapiens (human)Potency63.622311
activating transcription factor 6Homo sapiens (human)Potency35.698212
AR proteinHomo sapiens (human)Potency32.66131041
aryl hydrocarbon receptorHomo sapiens (human)Potency41.972422
Chain A, TYROSYL-DNA PHOSPHODIESTERASEHomo sapiens (human)Potency33.997212
chromobox protein homolog 1Homo sapiens (human)Potency63.095711
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency39.717113
DNA polymerase kappa isoform 1Homo sapiens (human)Potency26.679511
estrogen nuclear receptor alphaHomo sapiens (human)Potency36.62631027
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency59.507538
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency38.2893623
farnesoid X nuclear receptorHomo sapiens (human)Potency33.486444
gemininHomo sapiens (human)Potency0.117622
GLI family zinc finger 3Homo sapiens (human)Potency36.564125
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency26.568534
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency34.727313
heat shock protein beta-1Homo sapiens (human)Potency62.346911
Histone H2A.xCricetulus griseus (Chinese hamster)Potency107.098412
hypoxia-inducible factor 1 alpha subunitHomo sapiens (human)Potency27.722612
importin subunit beta-1 isoform 1Homo sapiens (human)Potency100.000011
LuciferasePhotinus pyralis (common eastern firefly)Potency93.570212
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency37.8176413
nuclear factor NF-kappa-B p105 subunit isoform 1Homo sapiens (human)Potency15.848911
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_aHomo sapiens (human)Potency34.839411
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency33.3387314
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency42.380937
Peroxisome proliferator-activated receptor alphaHomo sapiens (human)Potency50.118711
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency24.476947
pregnane X nuclear receptorHomo sapiens (human)Potency27.5622212
pregnane X receptorRattus norvegicus (Norway rat)Potency27.944312
progesterone receptorHomo sapiens (human)Potency27.582917
RAR-related orphan receptor gammaMus musculus (house mouse)Potency45.432627
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency18.378123
retinoid X nuclear receptor alphaHomo sapiens (human)Potency18.711538
SMAD family member 2Homo sapiens (human)Potency44.170224
SMAD family member 3Homo sapiens (human)Potency44.170224
snurportin-1Homo sapiens (human)Potency100.000011
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency65.407424
thyroid hormone receptor beta isoform aHomo sapiens (human)Potency0.199511
thyroid stimulating hormone receptorHomo sapiens (human)Potency33.740848
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency31.896822
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency34.200722
vitamin D3 receptor isoform VDRAHomo sapiens (human)Potency89.125111
Voltage-dependent calcium channel gamma-2 subunitMus musculus (house mouse)Potency34.727313

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Protoporphyrinogen oxidaseHomo sapiens (human)Ki0.968634
Protoporphyrinogen oxidase Zea maysIC500.003211
Protoporphyrinogen oxidase, chloroplasticNicotiana tabacum (common tobacco)Ki0.030011
Protoporphyrinogen oxidase, mitochondrialNicotiana tabacum (common tobacco)Ki0.070011