An EC 1.3.3.* (oxidoreductase acting on donor CH-CH group with oxygen as acceptor) inhibitor that interferes with the action of protoporphyrinogen oxidase (EC 1.3.3.4).
ChEBI ID: 73192
Member | Definition | Class |
---|---|---|
2,4,6-trichlorophenyl 4-nitrophenyl ether | chlornitrofen | |
acifluorfen | A member of the class of benzoic acids that is 2-nitrobenzoic acid in which the hydrogen at position 5 is replaced by a 2-chloro-4-(trifluoromethyl)phenoxy group. It is a herbicide used for the post-emergence control of a variety of annual broadleaf weeds. | acifluorfen |
aclonifen | A primary amino compound that is aniline in which the phenyl group has been substituted at positions 2, 3, and 6 by chlorine, phenoxy, and nitro groups, respectively. A protoporphyrinogen oxidase (PPO) inhibitor, it is used as a herbicide against a broad range of weeds in a wide range of crops. | aclonifen |
butafenacil | An organofluorine compound that is 1-methyl-6-(trifluoromethyl)pyrimidine-2,4(1H,3H)-dione substituted by a 4-chloro-3-({[2-methyl-1-oxo-1-(prop-2-en-1-yloxy)propan-2-yl]oxy}carbonyl)phenyl group at position 3. It is a herbicide which inhibits the protoporphyrinogen-oxidase enzyme in plant chloroplasts, resulting in rapid knockdown of various broadleaf and grass weeds. | butafenacil |
fomesafen | An N-sulfonylcarboxamide that is N-(methylsulfonyl)benzamide in which the phenyl ring is substituted by a nitro group at position 2 and a 2-chloro-4-(trifluoromethyl)phenoxy group at position 5. A protoporphyrinogen oxidase inhibitor, it was specially developed for use (generally as the corresponding sodium salt, fomesafen-sodium) for post-emergence control of broad-leaf weeds in soya. | fomesafen |
n-(2,4-dichloro-5-(4-(difluoromethyl)-4,5-dihydro-3-methyl-5-oxo-1h-1,2,4-triazol-1-yl)phenyl)methanesulfonamide | A member of the class of triazoles that is 5-oxo-1,2,4-triazole which is substituted at positions 1, 3, and 4 by 2,4-dichloro-5-[(methylsulfonyl)amino]phenyl, methyl, and difluoromethyl groups, respectively. A protoporphyrinogen oxidase inhibitor, it is used as a herbicide to control broad-leaved weeds in soya and tobacco crops. Not approved for use within the European Union. | sulfentrazone |
nitrofen | nitrofen | |
oxyfluorofen | Oxyfluorfen | |
s 53482 | A benzoxazine that is N-(prop-2-yn-1-yl)-2H-1,4-benzoxazin-3(4H)-one which is substituted at position 6 by a 1,3-dioxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl group and at position 7 by a fluorine. A protoporphyrinogen oxidase inhibitor, it is used for the control of weeds in soya, peanuts, and a variety of vegetable and fruit crops. | flumioxazin |
Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
---|---|---|
pre-1990 | 20,539 (59.22) | 18.7374 |
1990's | 5,208 (15.02) | 18.2507 |
2000's | 4,328 (12.48) | 29.6817 |
2010's | 3,540 (10.21) | 24.3611 |
2020's | 1,066 (3.07) | 2.80 |
Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
---|---|---|
Trials | 1,081 (2.77%) | 5.53% |
Reviews | 2,455 (6.28%) | 6.00% |
Case Studies | 790 (2.02%) | 4.05% |
Observational | 39 (0.10%) | 0.25% |
Other | 34,725 (88.83%) | 84.16% |
Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
---|---|---|---|---|---|
acetylcholinesterase | Homo sapiens (human) | Potency | 63.6223 | 1 | 1 |
activating transcription factor 6 | Homo sapiens (human) | Potency | 35.6982 | 1 | 2 |
AR protein | Homo sapiens (human) | Potency | 32.6613 | 10 | 41 |
aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 41.9724 | 2 | 2 |
Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 33.9972 | 1 | 2 |
chromobox protein homolog 1 | Homo sapiens (human) | Potency | 63.0957 | 1 | 1 |
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 39.7171 | 1 | 3 |
DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 26.6795 | 1 | 1 |
estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 36.6263 | 10 | 27 |
estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 59.5075 | 3 | 8 |
estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 38.2893 | 6 | 23 |
farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 33.4864 | 4 | 4 |
geminin | Homo sapiens (human) | Potency | 0.1176 | 2 | 2 |
GLI family zinc finger 3 | Homo sapiens (human) | Potency | 36.5641 | 2 | 5 |
glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 26.5685 | 3 | 4 |
Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 34.7273 | 1 | 3 |
heat shock protein beta-1 | Homo sapiens (human) | Potency | 62.3469 | 1 | 1 |
Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 107.0984 | 1 | 2 |
hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 27.7226 | 1 | 2 |
importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 100.0000 | 1 | 1 |
Luciferase | Photinus pyralis (common eastern firefly) | Potency | 93.5702 | 1 | 2 |
nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 37.8176 | 4 | 13 |
nuclear factor NF-kappa-B p105 subunit isoform 1 | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 34.8394 | 1 | 1 |
nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 33.3387 | 3 | 14 |
peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 42.3809 | 3 | 7 |
Peroxisome proliferator-activated receptor alpha | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 24.4769 | 4 | 7 |
pregnane X nuclear receptor | Homo sapiens (human) | Potency | 27.5622 | 2 | 12 |
pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 27.9443 | 1 | 2 |
progesterone receptor | Homo sapiens (human) | Potency | 27.5829 | 1 | 7 |
RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 45.4326 | 2 | 7 |
retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 18.3781 | 2 | 3 |
retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 18.7115 | 3 | 8 |
SMAD family member 2 | Homo sapiens (human) | Potency | 44.1702 | 2 | 4 |
SMAD family member 3 | Homo sapiens (human) | Potency | 44.1702 | 2 | 4 |
snurportin-1 | Homo sapiens (human) | Potency | 100.0000 | 1 | 1 |
thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 65.4074 | 2 | 4 |
thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 0.1995 | 1 | 1 |
thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 33.7408 | 4 | 8 |
v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 31.8968 | 2 | 2 |
vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 34.2007 | 2 | 2 |
vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 34.7273 | 1 | 3 |
Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
---|---|---|---|---|---|
Protoporphyrinogen oxidase | Homo sapiens (human) | Ki | 0.9686 | 3 | 4 |
Protoporphyrinogen oxidase | Zea mays | IC50 | 0.0032 | 1 | 1 |
Protoporphyrinogen oxidase, chloroplastic | Nicotiana tabacum (common tobacco) | Ki | 0.0300 | 1 | 1 |
Protoporphyrinogen oxidase, mitochondrial | Nicotiana tabacum (common tobacco) | Ki | 0.0700 | 1 | 1 |