A role played by a chemical compound which is known to induce a process of carcinogenesis by corrupting normal cellular pathways, leading to the acquistion of tumoral capabilities.
Member | Definition | Class |
1-methylnaphthalene | A methylnaphthalene carrying a methyl substituent at position 1. | 1-methylnaphthalene |
1-nitropyrene | A nitroarene that is pyrene substituted at the 1-position by a nitro group. A by-product of combustion, it is the predominant nitrated polycyclic aromatic hydrocarbon emitted in a diesel engine. | 1-nitropyrene |
1,2-dimethylhydrazine | A member of the class of hydrazines that is hydrazine in which one of the hydrogens attached to each nitrogen is replaced by a methyl group. A powerful DNA alkylating agent and carcinogen, it is used to induce colon cancer in laboratory rats and mice. | 1,2-dimethylhydrazine |
1,2-naphthoquinone | The parent structure of the family of 1,2-naphthoquinones, in which the oxo groups of the quinone moiety are at positions 1 and 2 of the naphthalene ring. It is a metabolite of naphthalene and is found in diesel exhaust particles. | 1,2-naphthoquinone |
1,3-butadiene | A butadiene with unsaturation at positions 1 and 3. | buta-1,3-diene |
1,4-dioxane | A dioxane with oxygen atoms at positions 1 and 4. | 1,4-dioxane |
1,5-naphthalenediamine | A naphthalenediamine compound having amino substituents in the 1- and 5-positions. | naphthalene-1,5-diamine |
2-acetylaminofluorene | The parent of the class of 2-acetamidofluorenes, being an ortho-fused polycyclic arene that consists of 9H-fluorene bearing an acetamido substituent at position 2. It is a carcinogenic and mutagenic derivative of fluorene. | 2-acetamidofluorene |
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine | An imidazopyridine that is 1H--imidazo[4,5-b]pyridine which is substituted at positions 1, 2, and 6 by methyl, amino, and phenyl groups, respectively. It is the most abundant of the mutagenic heterocyclic amines found in cooked meat and fish. | PhIP |
2-amino-3-methylimidazo(4,5-f)quinoline | An imidazoquinoline that is 3H-imidazo[4,5-f]quinoline substituted by a methyl group at position 3 and an amino group at position 2. | 3-methyl-3H-imidazo[4,5-f]quinolin-2-amine |
2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline | An imidazoquinoxaline that is 3H-imidazo[4,5-f]quinoxaline substituted at positions 3 and 8 by methyl groups and at position 2 by an amino group. A mutagenic compound found in cooked beef. | MeIQx |
2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine | An imidazopyridine that is 1H--imidazo[4,5-b]pyridine which is substituted at positions 1, 2, and 6 by methyl, hydoxyamino, and phenyl groups, respectively. The active metabolite of the dietary carcinogen PhIP. | N-hydroxy-PhIP |
2-hydroxyestradiol | A 2-hydroxy steroid that consists of 17beta-estradiol having an additional hydroxy group at position 2. | 2-hydroxy-17beta-estradiol |
2-naphthylamine | A naphthylamine carrying the amino group at position 2. | 2-naphthylamine |
2-nitroanisole | A member of the class of 2-nitroanisoles that is anisole in which one of the hydrogens ortho to the methoxy group is replaced by a nitro group. | 2-nitroanisole |
2-nitrofluorene | A nitroarene that is fluorene substituted by a nitro group at position 2. | 2-nitrofluorene |
2-nitropropane | A secondary nitroalkane that is propane in which a hydrogen at position 2 has been replaced by a nitro group. Mainly used as a solvent (b.p. 120degreeC). | 2-nitropropane |
2-nitrotoluene | A mononitrotoluene that is toluene carrying a nitro substituent at position 2. | 2-nitrotoluene |
2-toluidine | An aminotoluene in which the amino substituent is ortho to the methyl group. | o-toluidine |
2,4,6-trichlorophenol | A trichlorophenol with phenolic substituents on positions 2, 4 and 6. | 2,4,6-trichlorophenol |
2,6-dichlorobenzoquinone | A member of the class of 1,4-benzoquinones that is p-benzoquinone in which the hydrogens at positions 2 and 6 have been replaced by chlorines. A highly toxic and carcinogenic disinfection by-product found in drinking water. | 2,6-dichlorobenzoquinone |
2,6-xylidine | A primary arylamine that is aniline in which the hydrogens at the 2- and 6-positions are replaced by methyl groups. It is used in the production of some anasthetics and other chemicals. It is a drug metabolite of lidocaine (local anasthetic). | 2,6-dimethylaniline |
3-methylcholanthrene | A pentacyclic ortho- and peri-fused polycyclic arene consisting of a dihydrocyclopenta[ij]tetraphene ring system with a methyl substituent at the 3-position. | 3-methylcholanthrene |
3,6-diamino-10-methylacridinium chloride hydrochloride | A hydrochloride resulting from the reaction of equimolar amounts of 3,6-diamino-10-methylacridinium chloride and hydrogen chloride. | 3,6-diamino-10-methylacridinium chloride.HCl |
4-(methylnitrosamino)-1-(3-pyridyl)-1-butan-1-ol | A member of the class of nitrosamines that is butan-1-ol substituted by a pyridin-3-yl group at position 1 and by a methyl(nitroso)amino group at position 4. It is a major metabolite of nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), which is a carcinogen found in tobacco and responsible for inducing lung cancer in smokers. | 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol |
4-biphenylamine | An aminobiphenyl that is biphenyl substituted by an amino group at position 4. | biphenyl-4-amine |
4-hydroxyestrone | A 4-hydroxy steroid that is estrone substituted by a hydroxy group at position 4. | 4-hydroxyestrone |
4-methylcatechol | A methylcatechol having a single methyl substituent at the 4-position. It has been isolated from Picea abies. | 4-methylcatechol |
4-methylimidazole | Imidazole substituted at position 4 by a methyl group. | 4-methylimidazole |
4-nitroquinoline-1-oxide | A quinoline N-oxide carrying a nitro substituent at position 4. | 4-nitroquinoline N-oxide |
4-vinyl-1-cyclohexene dioxide | The diepoxide of 4-vinylcyclohexene. | 4-vinylcyclohexene dioxide |
4,4'-diaminodiphenylmethane | An aromatic amine that is diphenylmethane substituted at the 4-position of each benzene ring by an amino group. | 4,4'-diaminodiphenylmethane |
5-methoxyindoleacetic acid | A member of the class of indole-3-acetic acids in which the hydrogen at position 5 of indole-3-acetic acid has been replaced by a methoxy group. | 5-methoxyindole-3-acetic acid |
9,10-dimethyl-1,2-benzanthracene | A tetraphene having methyl substituents at the 7- and 12-positions. It is a potent carcinogen and is present in tobacco smoke. | 7,12-dimethyltetraphene |
acetaldehyde | The aldehyde formed from acetic acid by reduction of the carboxy group. It is the most abundant carcinogen in tobacco smoke. | acetaldehyde |
acetoxyacetylaminofluorene | A 2-acetamidofluorene compound in which the parent 2-acetamidofluorene is substituted on nitrogen by an acetoxy group. | N-acetoxy-2-acetamidofluorene |
acriflavine chloride | The 10-methochloride salt of 3,6-diaminoacridine. Note that a mixture of this compound with 3,6-diaminoacridine (proflavine) is known as acriflavine or neutral acriflavine. | 3,6-diamino-10-methylacridinium chloride |
acrylamide | A member of the class of acrylamides that results from the formal condensation of acrylic acid with ammonia. | acrylamide |
acrylonitrile | A nitrile that is hydrogen cyanide in which the hydrogen has been replaced by an ethenyl group. | acrylonitrile |
aflatoxin b1 | An aflatoxin having a tetrahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromene skeleton with oxygen functionality at positions 1, 4 and 11. | aflatoxin B1 |
aflatoxin q1 | A member of the class of aflatoxins that is aflatoxin B1 in which the hydrogen at the pro-3S position is replaced by a hydroxy group. | aflatoxin Q1 |
aplysiatoxin | The parent member of the class of aplysiatoxins. It is a cyanotoxin produced by several species of freshwater and marine cyanobacteria, as well as algae and molluscs. | aplysiatoxin |
aristolochic acid c | An aristolochic acid that is phenanthrene-1-carboxylic acid substituted by a methylenedioxy group at the 3,4 positions, by an hydroxy group at position 6, and by a nitro group at position 10. | aristolochic acid C |
aristolochic acid D | An aristolochic acid that is phenanthrene-1-carboxylic acid substituted by a methylenedioxy group at the 3,4 positions, by an hydroxy group at position 6, by a methoxy group at position 8, and by a nitro group at position 10. | aristolochic acid D |
aristolochic acid i | An aristolochic acid that is phenanthrene-1-carboxylic acid that is substituted by a methylenedioxy group at the 3,4 positions, by a methoxy group at position 8, and by a nitro group at position 10. It is the most abundant of the aristolochic acids and is found in almost all Aristolochia (birthworts or pipevines) species. It has been tried in a number of treatments for inflammatory disorders, mainly in Chinese and folk medicine. However, there is concern over their use as aristolochic acid is both carcinogenic and nephrotoxic. | aristolochic acid A |
aristolochic acid ii | An aristolochic acid that is phenanthrene-1-carboxylic acid substituted by a methylenedioxy group at the 3,4 positions and by a nitro group at position 10. | aristolochic acid B |
azathioprine | A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS. | azathioprine |
benzene | A six-carbon aromatic annulene in which each carbon atom donates one of its two 2p electrons into a delocalised pi system. A toxic, flammable liquid byproduct of coal distillation, it is used as an industrial solvent. Benzene is a carcinogen that also damages bone marrow and the central nervous system. | benzene |
benzidine | A member of the class of biphenyls that is 1,1'-biphenyl in which the hydrogen at the para-position of each phenyl group has been replaced by an amino group. | benzidine |
benzo(a)pyrene | An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings. | benzo[a]pyrene |
benzo(e)pyrene | An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings. It is listed as a Group 3 carcinogen by the IARC. | benzo[e]pyrene |
benzotrichloride | An organochlorine compound that is toluene in which all three hydrogens of the methyl group have been replaced by chlorines. It is used as an intermediate in organic synthesis and dye chemistry. | (trichloromethyl)benzene |
benzoyl chloride | An acyl chloride consisting of benzene in which a hydrogen is replaced by an acyl chloride group. It is an important chemical intermediate for the manufacture of other chemicals, dyes, perfumes, herbicides and pharmaceuticals. | benzoyl chloride |
beryllium | Alkaline earth metal atom with atomic number 4. | beryllium atom; beryllium(0) |
beryllium chloride | A compound of beryllium (+2 oxidation state) and chloride in the ratio 1:2. | beryllium dichloride |
beryllium oxide | A beryllium molecular entity consisting of beryllium (+2 oxidation state) and oxide in the ratio 1:1. In the solid state, BeO adopts the hexagonal wurtzite structure form while in the vapour phase, it is present as discrete diatomic covalent molecules. | beryllium oxide |
bis(chloromethyl) ether | An ether that is dimethyl ether in which one of the hydrogens attached to each of the methyl group has replaced by a chlorine. | bis(chloromethyl) ether |
bromoethane | A bromoalkane that is ethane carrying a bromo substituent. It is an alkylating agent used as a chemical intermediate in various organic syntheses. | bromoethane |
busulfan | A methanesulfonate ester that is butane-1,4-diol in which the hydrogens of the hydroxy groups are replaced by methanesulfonyl groups. An alkylating antineoplastic agent, it is used for the treatment of chronic myeloid leukemia (although it has been largely replaced by newer drugs). It is also used as an insect sterilant. | busulfan |
butyl(3-carboxypropyl)nitrosamine | A nitrosamine that has butyl and 4-carboxybutyl substituents. It is the principal metabolite of the bladder carcinogen N-butyl-N-(4-hydroxybutyl)nitrosamine (BHBN-4). | N-butyl-N-(3-carboxypropyl)nitrosamine |
butylhydroxybutylnitrosamine | A nitrosamine that has butyl and 4-hydroxybutyl substituents. In mice, it causes high-grade, invasive cancers in the urinary bladder, but not in any other tissues. | N-butyl-N-(4-hydroxybutyl)nitrosamine |
cadmium nitrate | An inorganic nitrate salt having Cd(2+) as the counterion. | cadmium nitrate |
captax | 1,3-Benzothiazole substituted at the 2-position with a sulfanyl group. | 1,3-benzothiazole-2-thiol |
chlorambucil | A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia. | chlorambucil |
chlorendic acid | A bridged organochlorine compound resulting from the Diels-Alder reaction of hexachlorocyclopentadiene with maleic anhydride followed by hydrolysis of the resulting anhydride. A chemical intermediate used in the preparation of fire-retardant polyester resins and plasticisers. | chlorendic acid |
chloroform | A one-carbon compound that is methane in which three of the hydrogens are replaced by chlorines. | chloroform |
colibactin | A member of the class of 1,3-thiazoles that comprises of two units of 2-[(2-{6-[(2S)-2-methyl-3,4-dihydro-2H-pyrrol-5-yl]-5-oxo-4-azaspiro[2.4]hept-6-en-7-yl}acetamido)methyl]-1,3-thiazole-4-carboxylic acid linked together via the formal condensation of the carboxy groups. It is a secondary metabolite produced by certain strains of bacteria found in the human gut such as Escherichia coli. It has the ability to bind covalently to DNA and is strongly associated with colorectal cancer. | colibactin |
cyclophosphamide | The monohydrate of cyclophosphamide. | cyclophosphamide hydrate |
cyclosporine | A cyclic nonribosomal peptide of eleven amino acids; an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection. Also causes reversible inhibition of immunocompetent lymphocytes in the G0- and G1-phase of the cell cycle. | cyclosporin A |
dacarbazine | A monocarboxylic acid amide that is 1H-imidazole-4-carboxamide which is substituted at position 5 by a 3,3-dimethyltriaz-1-en-1-yl group. It is used for the treatment of metastatic malignant melanoma, and in combination with other drugs for the treatment of Hodgkin's disease and soft-tissue sarcoma. | dacarbazine |
ddt | A chlorophenylethane that is 1,1,1-trichloro-2,2-diphenylethane substituted by additional chloro substituents at positions 4 of the phenyl substituents. It is a commonly used organochlorine insecticide. | DDT |
debromoaplysiatoxin | A member of the class of aplysiatoxins that has the structure of the parent aplysiatoxin, but is lacking the bromo substituent on the benzene ring at the position para to the phenolic hydroxy group. It is a cyanotoxin produced by several species of freshwater and marine cyanobacteria, as well as algae and molluscs. | debromoaplysiatoxin |
diazomethane | The simplest diazo compound, in which a diazo group is attached to a methylene group. | diazomethane |
dieldrin | An organochlorine compound resulting from the epoxidation of the double bond of aldrin. It is the active metabolite of the proinsecticde aldrin. | dieldrin |
diethyl sulfate | The diethyl ester of sulfuric acid. | diethyl sulfate |
diethylnitrosamine | A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom. | N-nitrosodiethylamine |
diethylstilbestrol | An olefinic compound that is trans-hex-3-ene in which the hydrogens at positions 3 and 4 have been replaced by p-hydroxyphenyl groups. | diethylstilbestrol |
diisopropanolnitrosamine | A nitrosamine that is dipropylamine in which the hydrogen attached to the nitrogen has been replaced by a nitroso group. It is a genotoxic carcinogen, targeting the lung, liver, thyroid, and kidney. | N,N-bis(2-hydroxypropyl)nitrosamine |
dimazine | A member of the class of hydrazines that is hydrazine substituted by two methyl groups at position 1. | 1,1-dimethylhydrazine |
estragole | A phenylpropanoid that is chavicol in which the hydroxy group is replaced by a methoxy group. | estragole |
ethionine | An S-ethylhomocysteine that has S-configuration at the chiral centre. | L-ethionine |
ethyl methanesulfonate | A methanesulfonate ester resulting from the formal condensation of methanesulfonic acid with ethanol. | ethyl methanesulfonate |
ethylene dibromide | A bromoalkane that is ethane carrying bromo substituents at positions 1 and 2. It is produced by marine algae. | 1,2-dibromoethane |
ethylnitrosourea | A member of the class of N-nitrosoureas that is urea in which one of the nitrogens is substituted by ethyl and nitroso groups. | N-ethyl-N-nitrosourea |
ferric nitrilotriacetate | An iron chelate resulting from the combination of equimolar amounts of iron(3+) and nitrilotriacetate(3-). | iron(III) nitrilotriacetate |
formaldehyde | An aldehyde resulting from the formal oxidation of methanol. | formaldehyde |
fumonisin b1 | A diester that results from the condensation of the 1-carboxy groups of two molecules of propane-1,2,3-tricarboxylic acid with hydroxy groups at positions 14 and 15 of (2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol. | fumonisin B1 |
fumonisin b2 | A fumonisin that is (2S,3S,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,14,15-triol in which the hydroxy groups at positions 14 and 15 have each been esterified by condensation with the 1-carboxy group of 3-carboxyglutaric acid (giving a 3-carboxyglutarate ester group with R configuration in each case). | fumonisin B2 |
furan | A monocyclic heteroarene with a structure consisting of a 5-membered ring containing four carbons and one oxygen, with formula C4H4O. It is a toxic, flammable, low-boiling (31degreeC) colourless liquid. | furan |
gw 501516 | An aromatic ether that is phenoxyacetic acid in which the phenyl group is substituted at position 2 by a methyl group and at position 4 by a (1,3-thiazol-5-ylmethyl)sulfanediyl group, and in which the 1,3-thiazolyl group is substituted at positions 2 and 4 by p-trifluoromethylphenyl and methyl groups, respectively. | GW 501516 |
hexachlorobenzene | A member of the class of chlorobenzenes that is benzene in which all of the hydrogens are replaced by chlorines. An agricultural fungicide introduced in the mid-1940s and formerly used as a seed treatment, its use has been banned since 1984 under the Stockholm Convention on Persistent Organic Pollutants. | hexachlorobenzene |
hexachloroethane | A member of the class of chloroethanes that is ethane in which all the hydrogens are replaced by chloro groups. | hexachloroethane |
hydroquinone | A benzenediol comprising benzene core carrying two hydroxy substituents para to each other. | hydroquinone |
lead chromate | A chromium coordination entity comprising chromate and lead(2+) ions in a 1:1 ratio | lead chromate |
malachite green | An organic chloride salt that is the monochloride salt of malachite green cation. Used as a green-coloured dye, as a counter-stain in histology, and for its anti-fungal properties in aquaculture. | malachite green |
melphalan | A phenylalanine derivative comprising L-phenylalanine having [bis(2-chloroethyl)amino group at the 4-position on the phenyl ring. | melphalan |
methanearsonous acid | A one-carbon compound that is arsonous acid in which the hydrogen attached to arsenic is replaced by a methyl group. | methylarsonous acid |
methapyrilene | A member of the class of ethylenediamine derivatives that is ethylenediamine in which one of the nitrogens is substituted by two methyl groups, and the other nitrogen is substituted by a 2-pyridyl group and a (2-thienyl)methyl group. | methapyrilene |
methapyrilene hydrochloride | A hydrochloride that is the monohydrochloride salt of methapyrilene. | methapyrilene hydrochloride |
methyl methanesulfonate | A methanesulfonate ester resulting from the formal condensation of methanesulfonic acid with methanol. | methyl methanesulfonate |
methylene chloride | A member of the class of chloromethanes that is methane in which two of the hydrogens have been replaced by chlorine. A dense, non-flammible colourless liquid at room temperature (b.p. 40degreeC, d = 1.33) which is immiscible with water, it is widely used as a solvent, a paint stripper, and for the removal of caffeine from coffee and tea. | dichloromethane |
methylnitrosourea | A member of the class of N-nitrosoureas that is urea in which one of the nitrogens is substituted by methyl and nitroso groups. | N-methyl-N-nitrosourea |
musk xylene | A C-nitro compound that is m-xylene bearing three nitro substituents at positions 2, 4 and 6 as well as a tert-butyl group at position 5. | musk xylene |
mustard gas | An ethyl sulfide that is diethyl sulfide in which a hydrogen from each of the terminal methyl groups is replaced by a chlorine. It is a powerful vesicant regulated under the Chemical Weapons Convention. | bis(2-chloroethyl) sulfide |
n-amyl-n-methylnitrosamine | A nitrosamine that has methyl and pentyl substituents. It is a potent oesophageal carcinogen. | N-methyl-N-pentylnitrosamine |
n-ethyl-n-hydroxyethylnitrosamine | A nitrosamine that is N-nitrosodiethylamine in which one of the ethyl froups has been replaced by a 2-hydroxyethyl group. It is used to induce renal and liver tumours in rodents. | N-ethyl-N-(2-hydroxyethyl)nitrosamine |
n-hydroxy-4-aminobiphenyl | A N-substituted amine that is 4-aminobiphenyl substituted by a hydroxy group at the nitrogen atom. | N-hydroxy-4-aminobiphenyl |
n-nitrosomorpholine | A nitrosamine that is morpholine in which the hydrogen attached to the nitrogen is replaced by a nitroso group. A carcinogen and mutagen, it is found in snuff tobacco. | N-nitrosomorpholine |
n-nitrosopiperidine | A nitrosamine that is piperidine in which the hydrogen attached to the nitrogen is replaced by a nitroso group. One of the many carcinogens detected in cigarette smoke, it is found in meat, cheese and spices that have been treated with the preservative sodium nitrite. | N-nitrosopiperidine |
n-nitrososarcosine | A nitrosamine that is sarcosine in which the hydrogen attached to the nitrogen has been replaced by a nitroso group. | N-nitrososarcosine |
naphthalene | An aromatic hydrocarbon comprising two fused benzene rings. It occurs in the essential oils of numerous plant species e.g. magnolia. | naphthalene |
nitrilotriacetic acid | | nitrilotriacetic acid |
nitrosobis(2-oxopropyl)amine | A nitrosamine that is iminodiacetone that is substituted by a nitroso group at the N-atom. It induces pancreatic ductal adenocarcinomas in Syrian golden hamsters (other rodents are not susceptible). | nitrosobis(2-oxopropyl)amine |
nitrosocarbaryl | A nitroso compound that is carbaryl in which the amino hydrogen is substituted by a nitroso group. | nitrosocarbaryl |
ochratoxin a | A phenylalanine derivative resulting from the formal condensation of the amino group of L-phenylalanine with the carboxy group of (3R)-5-chloro-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-carboxylic acid (ochratoxin alpha). It is among the most widely occurring food-contaminating mycotoxins, produced by Aspergillus ochraceus, Aspergillus carbonarius and Penicillium verrucosum. | ochratoxin A |
patulin | A furopyran and lactone that is (2H-pyran-3(6H)-ylidene)acetic acid which is substituted by hydroxy groups at positions 2 and 4 and in which the hydroxy group at position 4 has condensed with the carboxy group to give the corresponding bicyclic lactone. A mycotoxin produced by several species of Aspergillus and Penicillium, it has antibiotic properties but has been shown to be carcinogenic and mutagenic. | patulin |
perfluorooctanoic acid | A fluoroalkanoic acid that is perfluorinated octanoic acid. | perfluorooctanoic acid |
phenazopyridine | A diaminopyridine that is 2,6-diaminopyridine substituted at position 3 by a phenylazo group. A local anesthetic that has topical analgesic effect on mucosa lining of the urinary tract. Its use is limited by problems with toxicity (primarily blood disorders) and potential carcinogenicity. | phenazopyridine |
phenazopyridine hydrochloride | A hydrochloride obtained by combining phenazopyridine with one equivalent of hydrochloric acid. A local anesthetic that has topical analgesic effect on mucosa lining of the urinary tract. Its use is limited by problems with toxicity (primarily blood disorders) and potential carcinogenicity. | phenazopyridine hydrochloride |
phosphine | The simplest phosphine, consisting of a single phosphorus atom with three hydrogens attached. | phosphane |
ponceau mx | A naphthalenesulfonic acid that is naphthalene-2,7-disulfonic acid carrying additional hydroxy and (2,4-dimethylphenyl)diazenyl substituents at positions 3 and 4 respectively. The disodium salt is the biological stain 'acid red 26'. | 4-[(2,4-dimethylphenyl)diazenyl]-3-hydroxynaphthalene-2,7-disulfonic acid |
potassium chromate(vi) | A potassium salt consisting of potassium and chromate ions in a 2:1 ratio. | potassium chromate |
proflavine | An aminoacridine that is acridine that is substituted by amino groups at positions 3 and 6. A slow-acting bacteriostat that is effective against many Gram-positive bacteria (but ineffective against spores), its salts were formerly used for treatment of burns and infected wounds. | 3,6-diaminoacridine |
propylthiouracil | A pyrimidinethione consisting of uracil in which the 2-oxo group is substituted by a thio group and the hydrogen at position 6 is substituted by a propyl group. | 6-propyl-2-thiouracil |
riddelliine | A macrodiolide that is 13,19-didehydrosenecionan bearing two additional hydroxy substituents at positions 12 and 18 as well as two additional oxo groups at positions 11 and 16. | riddelliine |
riddelliine n-oxide | A pyrrolizine alkaloid that is 13,19-didehydrosenecionane bearing two additional hydroxy substituents at positions 12 and 18, two additional oxo groups at positions 11 and 16 and an N-oxido substituent. | riddelliine N-oxide |
scarlet red | A bis(azo) compound that is 2-naphthol substituted at position 1 by a {2-methyl-4-[(2-methylphenyl)diazenyl]phenyl}diazenyl group. A fat-soluble dye predominantly used for demonstrating triglycerides in frozen sections, but which may also stain some protein bound lipids in paraffin sections. | Sudan IV |
semustine | An organochlorine compound that is urea in which the two hydrogens on one of the amino groups are replaced by nitroso and 2-chloroethyl groups and one hydrogen from the other amino group is replaced by a 4-methylcyclohexyl group. | semustine |
sodium arsenite | An inoganic sodium salt with formula with formula NaAsO2. | sodium arsenite |
sodium chromate(vi) | An inorganic sodium salt consisting of sodium and chromate ions in a 2:1 ratio. | sodium chromate |
sudan iii | A bis(azo) compound that is 2-naphthol substituted at position 1 by a 4-{[(2-methylphenyl)diazenyl]phenyl}diazenyl group. A fat-soluble dye predominantly used for demonstrating triglycerides in frozen sections, but which may also stain some protein bound lipids in paraffin sections. | Sudan III |
sulfamethazine | A sulfonamide consisting of pyrimidine with methyl substituents at the 4- and 6-positions and a 4-aminobenzenesulfonamido group at the 2-position. | sulfamethazine |
tetradecanoylphorbol acetate | A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types. | phorbol 13-acetate 12-myristate |
thiamethoxam | An oxadiazane that is tetrahydro-N-nitro-4H-1,3,5-oxadiazin-4-imine bearing (2-chloro-1,3-thiazol-5-yl)methyl and methyl substituents at positions 3 and 5 respectively. | thiamethoxam |
trichloroacetic acid | A monocarboxylic acid that is acetic acid in which all three methyl hydrogens are substituted by chlorine. | trichloroacetic acid |
versicolorin a | An organic heteropentacyclic compound that is 3a,12a-dihydroanthra[2,3-b]furo[3,2-d]furan-5,10-dione carrying three hydroxy substituents at positions 4, 6 and 8. | versicolorin A |
vinyl chloride | A monohaloethene that is ethene in which one of the hydrogens has been replaced by a chloro group. | chloroethene |
vinylidene chloride | A member of the class of chloroethenes that is ethene in which both of the hydrogens attached to one of the carbons are replaced by chlorines. | 1,1-dichloroethene |
xanthurenic acid 8-methyl ether | A quinolinemonocarboxylic acid that is kynurenic acid which is substituted by a methoxy group at position 8. | 4-hydroxy-8-methoxyquinaldic acid |
Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 15.3629 | 1 | 12 |
15-lipoxygenase, partial | Homo sapiens (human) | Potency | 28.8522 | 1 | 9 |
67.9K protein | Vaccinia virus | Potency | 5.6082 | 2 | 10 |
acetylcholinesterase | Homo sapiens (human) | Potency | 45.7832 | 4 | 27 |
acid sphingomyelinase | Homo sapiens (human) | Potency | 25.1189 | 1 | 2 |
activating transcription factor 6 | Homo sapiens (human) | Potency | 37.3095 | 2 | 30 |
aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 25.8916 | 1 | 35 |
alpha-galactosidase | Homo sapiens (human) | Potency | 27.7170 | 2 | 2 |
Alpha-synuclein | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
apical membrane antigen 1, AMA1 | Plasmodium falciparum 3D7 | Potency | 20.0084 | 1 | 8 |
AR protein | Homo sapiens (human) | Potency | 24.2265 | 12 | 223 |
aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 29.2388 | 3 | 83 |
arylsulfatase A | Homo sapiens (human) | Potency | 15.1035 | 1 | 2 |
ATAD5 protein, partial | Homo sapiens (human) | Potency | 16.7846 | 3 | 9 |
Ataxin-2 | Homo sapiens (human) | Potency | 34.1738 | 2 | 17 |
ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 6.0062 | 4 | 6 |
ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 35.3669 | 2 | 25 |
Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 3.9614 | 3 | 8 |
BRCA1 | Homo sapiens (human) | Potency | 11.7947 | 1 | 3 |
bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 60.2671 | 1 | 7 |
caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 38.4702 | 1 | 10 |
caspase-1 isoform alpha precursor | Homo sapiens (human) | Potency | 17.8020 | 1 | 2 |
caspase-3 | Cricetulus griseus (Chinese hamster) | Potency | 46.9176 | 1 | 9 |
caspase-3 | Homo sapiens (human) | Potency | 38.4702 | 1 | 10 |
Caspase-7 | Cricetulus griseus (Chinese hamster) | Potency | 46.9176 | 1 | 9 |
Caspase-7 | Homo sapiens (human) | Potency | 17.3926 | 1 | 2 |
Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 36.0797 | 3 | 81 |
cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 9.4757 | 2 | 11 |
Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 20.6233 | 1 | 10 |
Chain A, ATP-DEPENDENT DNA HELICASE Q1 | Homo sapiens (human) | Potency | 25.9302 | 1 | 3 |
Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 8.6585 | 2 | 5 |
Chain A, Breast cancer type 1 susceptibility protein | Homo sapiens (human) | Potency | 1.2589 | 1 | 1 |
Chain A, Cruzipain | Trypanosoma cruzi | Potency | 24.5197 | 1 | 7 |
Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 23.5598 | 1 | 6 |
Chain A, HADH2 protein | Homo sapiens (human) | Potency | 24.9723 | 2 | 18 |
Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 50.7015 | 1 | 7 |
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 11.9049 | 2 | 14 |
Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 10.9401 | 2 | 6 |
Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 35.1933 | 1 | 20 |
Chain B, HADH2 protein | Homo sapiens (human) | Potency | 24.9723 | 2 | 18 |
chaperonin-containing TCP-1 beta subunit homolog | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
chromobox protein homolog 1 | Homo sapiens (human) | Potency | 69.7203 | 2 | 21 |
ClpP | Bacillus subtilis | Potency | 33.9972 | 1 | 2 |
cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 5.5528 | 1 | 2 |
cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 27.8298 | 1 | 2 |
cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 18.8091 | 1 | 9 |
cytochrome P450 2D6 | Homo sapiens (human) | Potency | 19.9462 | 1 | 9 |
cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 1.0430 | 1 | 2 |
cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 16.6774 | 2 | 42 |
cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 10.4726 | 2 | 15 |
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 21.1365 | 1 | 34 |
Disintegrin and metalloproteinase domain-containing protein 17 | Homo sapiens (human) | Potency | 10.9016 | 1 | 6 |
DNA dC->dU-editing enzyme APOBEC-3F isoform a | Homo sapiens (human) | Potency | 6.2050 | 1 | 2 |
DNA dC->dU-editing enzyme APOBEC-3G isoform 1 | Homo sapiens (human) | Potency | 13.5160 | 1 | 2 |
DNA polymerase beta | Homo sapiens (human) | Potency | 16.9308 | 1 | 2 |
DNA polymerase eta isoform 1 | Homo sapiens (human) | Potency | 57.2496 | 2 | 6 |
DNA polymerase III, partial | Bacillus subtilis | Potency | 5.3233 | 1 | 1 |
DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 49.0520 | 2 | 12 |
DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 24.4590 | 2 | 10 |
endonuclease IV | Escherichia coli | Potency | 10.0000 | 1 | 1 |
Endothelin receptor type B | Rattus norvegicus (Norway rat) | Potency | 0.5623 | 1 | 1 |
Endothelin-1 receptor | Rattus norvegicus (Norway rat) | Potency | 0.5623 | 1 | 1 |
estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 24.1828 | 12 | 330 |
estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 36.6496 | 3 | 56 |
estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 27.6381 | 10 | 252 |
euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 18.2951 | 1 | 24 |
EWS/FLI fusion protein | Homo sapiens (human) | Potency | 12.9676 | 4 | 22 |
farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 35.8529 | 5 | 60 |
flap endonuclease 1 | Homo sapiens (human) | Potency | 32.2405 | 1 | 5 |
fructose-bisphosphate aldolase A | Oryctolagus cuniculus (rabbit) | Potency | 63.0957 | 1 | 1 |
Fumarate hydratase | Homo sapiens (human) | Potency | 22.2302 | 1 | 8 |
G | Vesicular stomatitis virus | Potency | 18.8091 | 1 | 9 |
GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 17.0514 | 1 | 22 |
GALC protein | Homo sapiens (human) | Potency | 1.1464 | 1 | 2 |
Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 17.0514 | 1 | 22 |
Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 17.0514 | 1 | 22 |
Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 17.0514 | 1 | 22 |
Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 17.0514 | 1 | 22 |
Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 17.0514 | 1 | 22 |
Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 17.0514 | 1 | 22 |
Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 17.0514 | 1 | 22 |
Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 17.0514 | 1 | 22 |
Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 17.0514 | 1 | 22 |
Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 17.0514 | 1 | 22 |
Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 17.0514 | 1 | 22 |
Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 17.0514 | 1 | 22 |
Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 17.0514 | 1 | 22 |
Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 17.0514 | 1 | 22 |
Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 17.0514 | 1 | 22 |
geminin | Homo sapiens (human) | Potency | 11.0266 | 3 | 55 |
GLI family zinc finger 3 | Homo sapiens (human) | Potency | 22.4739 | 3 | 75 |
glp-1 receptor, partial | Homo sapiens (human) | Potency | 15.5904 | 2 | 10 |
GLS protein | Homo sapiens (human) | Potency | 19.5052 | 2 | 12 |
glucocerebrosidase | Homo sapiens (human) | Potency | 27.1445 | 1 | 3 |
glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 29.9055 | 5 | 77 |
Glutamate receptor 1 | Rattus norvegicus (Norway rat) | Potency | 6.3096 | 1 | 1 |
Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 25.6843 | 2 | 28 |
Glutamate receptor 3 | Rattus norvegicus (Norway rat) | Potency | 6.3096 | 1 | 1 |
Glutamate receptor 4 | Rattus norvegicus (Norway rat) | Potency | 6.3096 | 1 | 1 |
GTP-binding nuclear protein Ran isoform 1 | Homo sapiens (human) | Potency | 2.3951 | 1 | 4 |
Guanine nucleotide-binding protein G | Homo sapiens (human) | Potency | 26.9366 | 2 | 6 |
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | Homo sapiens (human) | Potency | 23.0228 | 1 | 5 |
heat shock protein beta-1 | Homo sapiens (human) | Potency | 43.0570 | 2 | 29 |
hemoglobin subunit beta | Homo sapiens (human) | Potency | 8.5728 | 5 | 16 |
Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 26.0416 | 2 | 14 |
histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 30.2946 | 1 | 6 |
histone deacetylase 9 isoform 3 | Homo sapiens (human) | Potency | 30.0726 | 2 | 17 |
Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 63.6109 | 2 | 48 |
histone-lysine N-methyltransferase 2A isoform 2 precursor | Homo sapiens (human) | Potency | 25.8479 | 1 | 4 |
HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 18.8091 | 1 | 9 |
huntingtin isoform 2 | Homo sapiens (human) | Potency | 11.2947 | 1 | 2 |
hypothetical protein, conserved | Trypanosoma brucei | Potency | 13.1692 | 3 | 4 |
hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 39.5027 | 2 | 29 |
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 19.0280 | 3 | 16 |
IDH1 | Homo sapiens (human) | Potency | 10.9348 | 1 | 8 |
importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 25.3974 | 2 | 7 |
Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 18.8091 | 1 | 18 |
Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 9.8232 | 1 | 5 |
Integrin alpha-IIb | Homo sapiens (human) | Potency | 4.0736 | 1 | 6 |
Integrin beta-3 | Homo sapiens (human) | Potency | 4.0736 | 1 | 6 |
Interferon beta | Homo sapiens (human) | Potency | 20.2576 | 2 | 10 |
interleukin 8 | Homo sapiens (human) | Potency | 71.8638 | 1 | 16 |
lamin isoform A-delta10 | Homo sapiens (human) | Potency | 9.7711 | 2 | 19 |
lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 13.6156 | 1 | 13 |
lethal(3)malignant brain tumor-like protein 1 isoform I | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
Luciferase | Photinus pyralis (common eastern firefly) | Potency | 35.5753 | 4 | 33 |
lysosomal alpha-glucosidase preproprotein | Homo sapiens (human) | Potency | 19.3097 | 2 | 2 |
M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 64.4679 | 1 | 2 |
Microtubule-associated protein tau | Homo sapiens (human) | Potency | 15.3863 | 2 | 24 |
mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 18.6758 | 2 | 10 |
muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 20.8401 | 2 | 6 |
muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 33.8994 | 1 | 4 |
neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 18.8541 | 1 | 2 |
NFKB1 protein, partial | Homo sapiens (human) | Potency | 6.8969 | 2 | 6 |
nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 3.1635 | 1 | 3 |
NPC intracellular cholesterol transporter 1 precursor | Homo sapiens (human) | Potency | 48.2333 | 1 | 2 |
Nrf2 | Homo sapiens (human) | Potency | 18.3564 | 1 | 1 |
nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 32.8741 | 4 | 132 |
nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 10.2582 | 2 | 9 |
nuclear factor NF-kappa-B p105 subunit isoform 1 | Homo sapiens (human) | Potency | 39.7810 | 1 | 4 |
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 37.3966 | 2 | 27 |
Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 30.0215 | 1 | 18 |
nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 13.4715 | 2 | 27 |
nuclear receptor subfamily 1, group I, member 2 | Rattus norvegicus (Norway rat) | Potency | 5.0119 | 1 | 1 |
nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 24.1456 | 3 | 137 |
P53 | Homo sapiens (human) | Potency | 52.1572 | 1 | 3 |
parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 49.4833 | 1 | 5 |
Parkin | Homo sapiens (human) | Potency | 29.0929 | 1 | 1 |
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 39.4144 | 2 | 4 |
peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 13.7519 | 2 | 12 |
peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 34.2980 | 1 | 3 |
peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 33.5187 | 5 | 67 |
peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 30.1730 | 5 | 62 |
phosphopantetheinyl transferase | Bacillus subtilis | Potency | 36.6495 | 3 | 11 |
plasminogen precursor | Mus musculus (house mouse) | Potency | 5.2513 | 1 | 9 |
polyprotein | Zika virus | Potency | 22.2302 | 1 | 8 |
polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | Potency | 25.5154 | 1 | 2 |
Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 24.7005 | 1 | 4 |
potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 22.3233 | 1 | 9 |
pregnane X nuclear receptor | Homo sapiens (human) | Potency | 34.7521 | 3 | 63 |
pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 39.3687 | 1 | 14 |
progesterone receptor | Homo sapiens (human) | Potency | 35.1642 | 2 | 38 |
pyruvate kinase | Leishmania mexicana mexicana | Potency | 3.4384 | 3 | 3 |
pyruvate kinase PKM isoform a | Homo sapiens (human) | Potency | 6.4720 | 2 | 4 |
Rap guanine nucleotide exchange factor 3 | Homo sapiens (human) | Potency | 33.1093 | 2 | 6 |
Rap guanine nucleotide exchange factor 4 | Homo sapiens (human) | Potency | 75.4550 | 2 | 4 |
RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 23.7956 | 2 | 91 |
ras-related protein Rab-9A | Homo sapiens (human) | Potency | 22.5066 | 1 | 3 |
regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 46.4137 | 1 | 3 |
retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 32.1273 | 3 | 141 |
retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 33.9150 | 4 | 87 |
serine-protein kinase ATM isoform a | Homo sapiens (human) | Potency | 17.7828 | 1 | 1 |
serine/threonine-protein kinase mTOR isoform 1 | Homo sapiens (human) | Potency | 17.5531 | 3 | 3 |
serine/threonine-protein kinase PLK1 | Homo sapiens (human) | Potency | 16.4136 | 1 | 5 |
SMAD family member 2 | Homo sapiens (human) | Potency | 33.2281 | 3 | 21 |
SMAD family member 3 | Homo sapiens (human) | Potency | 33.2281 | 3 | 21 |
Smad3 | Homo sapiens (human) | Potency | 14.2956 | 1 | 8 |
snurportin-1 | Homo sapiens (human) | Potency | 25.3974 | 2 | 7 |
Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 29.4124 | 1 | 6 |
survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 13.9445 | 1 | 15 |
TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 21.7117 | 1 | 5 |
TDP1 protein | Homo sapiens (human) | Potency | 17.5069 | 2 | 60 |
thioredoxin glutathione reductase | Schistosoma mansoni | Potency | 30.5571 | 1 | 8 |
thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 35.7266 | 3 | 18 |
Thrombopoietin | Homo sapiens (human) | Potency | 11.2947 | 2 | 4 |
thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 30.1237 | 3 | 86 |
thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 29.0177 | 4 | 23 |
thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 29.4652 | 7 | 95 |
thyrotropin-releasing hormone receptor | Homo sapiens (human) | Potency | 27.8904 | 2 | 5 |
transcriptional regulator ERG isoform 3 | Homo sapiens (human) | Potency | 28.8374 | 1 | 3 |
tumor necrosis factor | Homo sapiens (human) | Potency | 36.0062 | 1 | 2 |
tumor susceptibility gene 101 protein | Homo sapiens (human) | Potency | 10.0000 | 1 | 2 |
ubiquitin carboxyl-terminal hydrolase 2 isoform a | Homo sapiens (human) | Potency | 10.9016 | 1 | 6 |
urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 5.2513 | 1 | 9 |
urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 5.2513 | 1 | 9 |
USP1 protein, partial | Homo sapiens (human) | Potency | 76.6091 | 2 | 10 |
v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 29.5676 | 2 | 35 |
vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 23.1947 | 5 | 45 |
vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 53.6487 | 1 | 7 |
Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 26.4019 | 1 | 27 |
Vpr | Human immunodeficiency virus 1 | Potency | 14.1254 | 1 | 1 |
WRN | Homo sapiens (human) | Potency | 15.9002 | 2 | 4 |
Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
5-hydroxytryptamine receptor 2A | Homo sapiens (human) | IC50 | 2.7090 | 1 | 2 |
5-hydroxytryptamine receptor 2A | Homo sapiens (human) | Ki | 0.7745 | 1 | 2 |
5-hydroxytryptamine receptor 2B | Homo sapiens (human) | IC50 | 2.3843 | 1 | 3 |
5-hydroxytryptamine receptor 2B | Homo sapiens (human) | Ki | 1.5173 | 1 | 3 |
5-hydroxytryptamine receptor 2C | Homo sapiens (human) | IC50 | 17.9020 | 1 | 3 |
5-hydroxytryptamine receptor 2C | Homo sapiens (human) | Ki | 9.3770 | 1 | 3 |
5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | IC50 | 17.9020 | 1 | 3 |
5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | Ki | 9.3770 | 1 | 3 |
5-hydroxytryptamine receptor 6 | Homo sapiens (human) | IC50 | 7.9915 | 1 | 2 |
5-hydroxytryptamine receptor 6 | Homo sapiens (human) | Ki | 3.7105 | 1 | 2 |
Acetylcholinesterase | Homo sapiens (human) | IC50 | 25.4110 | 1 | 3 |
Acetylcholinesterase | Electrophorus electricus (electric eel) | Ki | 0.0012 | 1 | 1 |
Acetylcholinesterase | Homo sapiens (human) | Ki | 9.5467 | 3 | 3 |
Acetylcholinesterase | Mus musculus (house mouse) | Ki | 28.0000 | 1 | 1 |
Adenosine receptor A1 | Bos taurus (cattle) | IC50 | 3.0000 | 1 | 1 |
Adenosine receptor A1 | Homo sapiens (human) | IC50 | 2.8560 | 1 | 1 |
Adenosine receptor A1 | Homo sapiens (human) | Ki | 1.6660 | 1 | 1 |
Adenosine receptor A2a | Homo sapiens (human) | IC50 | 9.0130 | 1 | 1 |
Adenosine receptor A2a | Homo sapiens (human) | Ki | 5.0600 | 1 | 1 |
Adenosine receptor A3 | Homo sapiens (human) | IC50 | 3.8760 | 1 | 2 |
Adenosine receptor A3 | Homo sapiens (human) | Ki | 2.1910 | 1 | 2 |
Adenylate cyclase type 10 | Homo sapiens (human) | IC50 | 3.0000 | 1 | 1 |
Alcohol dehydrogenase E chain | Equus caballus (horse) | Ki | 7,762.4700 | 1 | 1 |
Alcohol dehydrogenase S chain | Equus caballus (horse) | Ki | 7,762.4700 | 1 | 1 |
Aldehyde oxidase | Homo sapiens (human) | IC50 | 0.4600 | 1 | 1 |
Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | IC50 | 10.8265 | 1 | 4 |
Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | Ki | 10.7373 | 1 | 4 |
Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 5.6973 | 2 | 3 |
Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 2.1910 | 1 | 2 |
Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 5.6973 | 2 | 3 |
Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 2.1910 | 1 | 2 |
Alpha-1D adrenergic receptor | Homo sapiens (human) | IC50 | 10.8260 | 1 | 1 |
Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 9.3400 | 1 | 1 |
Alpha-1D adrenergic receptor | Homo sapiens (human) | Ki | 5.3210 | 1 | 1 |
Alpha-2A adrenergic receptor | Homo sapiens (human) | IC50 | 10.2905 | 1 | 4 |
Alpha-2A adrenergic receptor | Homo sapiens (human) | Ki | 3.8588 | 1 | 4 |
Alpha-2B adrenergic receptor | Homo sapiens (human) | IC50 | 7.5080 | 1 | 2 |
Alpha-2B adrenergic receptor | Homo sapiens (human) | Ki | 3.4275 | 1 | 2 |
Alpha-2C adrenergic receptor | Homo sapiens (human) | IC50 | 15.1510 | 1 | 1 |
Alpha-2C adrenergic receptor | Homo sapiens (human) | Ki | 2.2010 | 1 | 1 |
Amine oxidase [flavin-containing] A | Homo sapiens (human) | IC50 | 3.0155 | 1 | 2 |
Androgen receptor | Rattus norvegicus (Norway rat) | IC50 | 11.9297 | 2 | 4 |
Androgen receptor | Rattus norvegicus (Norway rat) | Ki | 4.5900 | 1 | 1 |
ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 98.3759 | 2 | 7 |
ATP-dependent translocase ABCB1 | Homo sapiens (human) | IC50 | 3.0464 | 41 | 42 |
ATP-dependent translocase ABCB1 | Mus musculus (house mouse) | IC50 | 2.7500 | 4 | 4 |
ATP-dependent translocase ABCB1 | Homo sapiens (human) | Ki | 1.7183 | 6 | 6 |
ATP-dependent translocase ABCB1 | Mus musculus (house mouse) | Ki | 3.5750 | 2 | 2 |
Beta-1 adrenergic receptor | Homo sapiens (human) | IC50 | 22.0880 | 1 | 1 |
Beta-1 adrenergic receptor | Homo sapiens (human) | Ki | 12.7550 | 1 | 1 |
Beta-1 adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.0018 | 1 | 1 |
Bile salt export pump | Homo sapiens (human) | IC50 | 312.6848 | 8 | 23 |
Bile salt export pump | Rattus norvegicus (Norway rat) | IC50 | 666.8667 | 1 | 3 |
Bile salt export pump | Homo sapiens (human) | Ki | 9.5000 | 1 | 1 |
Bile salt export pump | Rattus norvegicus (Norway rat) | Ki | 0.3000 | 1 | 1 |
Broad substrate specificity ATP-binding cassette transporter ABCG2 | Homo sapiens (human) | IC50 | 14.9927 | 5 | 5 |
Broad substrate specificity ATP-binding cassette transporter ABCG2 | Homo sapiens (human) | Ki | 0.5000 | 1 | 1 |
Calcineurin subunit B type 1 | Homo sapiens (human) | IC50 | 34.0000 | 1 | 1 |
Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 73.9064 | 6 | 11 |
Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | Ki | 11.2700 | 3 | 3 |
Canalicular multispecific organic anion transporter 1 | Rattus norvegicus (Norway rat) | Ki | 5.9800 | 2 | 2 |
Carbonic anhydrase | Dicentrarchus labrax (European seabass) | Ki | 5.9300 | 1 | 1 |
Carbonic anhydrase 1 | Homo sapiens (human) | IC50 | 91.5000 | 1 | 2 |
Carbonic anhydrase 1 | Homo sapiens (human) | Ki | 112.3295 | 5 | 20 |
Carbonic anhydrase 12 | Homo sapiens (human) | Ki | 112.4860 | 3 | 15 |
Carbonic anhydrase 13 | Mus musculus (house mouse) | Ki | 121.6993 | 2 | 14 |
Carbonic anhydrase 14 | Homo sapiens (human) | Ki | 119.3921 | 2 | 14 |
Carbonic anhydrase 15 | Mus musculus (house mouse) | Ki | 10.6000 | 1 | 1 |
Carbonic anhydrase 2 | Homo sapiens (human) | IC50 | 91.5000 | 1 | 2 |
Carbonic anhydrase 2 | Homo sapiens (human) | Ki | 111.2685 | 5 | 20 |
Carbonic anhydrase 3 | Homo sapiens (human) | Ki | 116.9779 | 2 | 14 |
Carbonic anhydrase 4 | Homo sapiens (human) | Ki | 121.4439 | 3 | 18 |
Carbonic anhydrase 5A, mitochondrial | Homo sapiens (human) | Ki | 117.3993 | 2 | 14 |
Carbonic anhydrase 5B, mitochondrial | Homo sapiens (human) | Ki | 117.2850 | 2 | 14 |
Carbonic anhydrase 6 | Homo sapiens (human) | Ki | 149.7883 | 3 | 18 |
Carbonic anhydrase 7 | Homo sapiens (human) | Ki | 179.4636 | 2 | 14 |
Carbonic anhydrase 9 | Homo sapiens (human) | Ki | 114.1327 | 3 | 15 |
Chain A, 3C-like proteinase | Severe acute respiratory syndrome-related coronavirus | Ki | 0.7000 | 1 | 1 |
Chain A, Carbonic anhydrase 2 | Homo sapiens (human) | Ki | 0.0900 | 1 | 3 |
Chain A, Integrase | Human immunodeficiency virus 1 | IC50 | 380.0000 | 1 | 2 |
Chain A, Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | Ki | 0.7000 | 1 | 1 |
Cholinesterase | Homo sapiens (human) | Ki | 1.6460 | 3 | 5 |
Coagulation factor XII | Homo sapiens (human) | Ki | 1.8733 | 1 | 3 |
corticotropin releasing factor-binding protein | Homo sapiens (human) | IC50 | 47.1000 | 1 | 1 |
corticotropin-releasing hormone receptor 2 | Homo sapiens (human) | IC50 | 47.1000 | 1 | 1 |
Cyclin-dependent kinase 2 | Homo sapiens (human) | IC50 | 23.7500 | 1 | 4 |
Cysteinyl leukotriene receptor 1 | Homo sapiens (human) | IC50 | 17.7450 | 1 | 1 |
Cysteinyl leukotriene receptor 1 | Homo sapiens (human) | Ki | 8.8720 | 1 | 1 |
cystic fibrosis transmembrane conductance regulator | Homo sapiens (human) | IC50 | 8.8800 | 1 | 1 |
Cytochrome P450 1A2 | Homo sapiens (human) | IC50 | 130.0651 | 3 | 7 |
Cytochrome P450 2A5 | Mus musculus (house mouse) | IC50 | 48.9872 | 2 | 4 |
Cytochrome P450 2A6 | Homo sapiens (human) | IC50 | 29.4915 | 2 | 4 |
Cytochrome P450 2C19 | Homo sapiens (human) | IC50 | 7.0000 | 1 | 1 |
Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 38.8000 | 1 | 1 |
Cytochrome P450 2D6 | Homo sapiens (human) | IC50 | 55.9521 | 3 | 3 |
Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 3.7340 | 4 | 5 |
Cytochrome P450 3A4 | Homo sapiens (human) | Ki | 6.0550 | 2 | 4 |
Cytochrome P450 3A43 | Homo sapiens (human) | IC50 | 2.0600 | 1 | 1 |
Cytochrome P450 3A43 | Homo sapiens (human) | Ki | 7.6000 | 1 | 2 |
Cytochrome P450 3A5 | Homo sapiens (human) | IC50 | 2.0600 | 1 | 1 |
Cytochrome P450 3A5 | Homo sapiens (human) | Ki | 7.6000 | 1 | 2 |
Cytochrome P450 3A7 | Homo sapiens (human) | IC50 | 2.0600 | 1 | 1 |
Cytochrome P450 3A7 | Homo sapiens (human) | Ki | 7.6000 | 1 | 2 |
D(1A) dopamine receptor | Homo sapiens (human) | IC50 | 7.7630 | 1 | 1 |
D(1A) dopamine receptor | Homo sapiens (human) | Ki | 3.8820 | 1 | 1 |
D(2) dopamine receptor | Homo sapiens (human) | IC50 | 13.3210 | 1 | 1 |
D(2) dopamine receptor | Homo sapiens (human) | Ki | 4.4400 | 1 | 1 |
D(3) dopamine receptor | Homo sapiens (human) | IC50 | 8.7960 | 1 | 1 |
D(3) dopamine receptor | Homo sapiens (human) | Ki | 2.9870 | 1 | 1 |
Delta-type opioid receptor | Homo sapiens (human) | IC50 | 2.7180 | 1 | 1 |
Delta-type opioid receptor | Homo sapiens (human) | Ki | 0.9580 | 1 | 1 |
Dihydroorotate dehydrogenase (quinone), mitochondrial | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
Disabled homolog 2-interacting protein | Homo sapiens (human) | Ki | 1.2600 | 1 | 1 |
DNA dC->dU-editing enzyme APOBEC-3G isoform 1 | Homo sapiens (human) | IC50 | 10.6100 | 1 | 1 |
Estrogen receptor | Homo sapiens (human) | IC50 | 0.1312 | 6 | 6 |
Estrogen receptor | Homo sapiens (human) | Ki | 0.0002 | 5 | 5 |
Estrogen receptor beta | Homo sapiens (human) | IC50 | 0.1588 | 4 | 4 |
Estrogen receptor beta | Homo sapiens (human) | Ki | 0.0003 | 3 | 3 |
Fibroblast growth factor receptor 4 | Homo sapiens (human) | IC50 | 0.9380 | 1 | 1 |
fMet-Leu-Phe receptor | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
Genome polyprotein | | IC50 | 3.8000 | 1 | 1 |
Genome polyprotein | Human rhinovirus sp. | IC50 | 8.2000 | 1 | 1 |
Glucocorticoid receptor | Homo sapiens (human) | IC50 | 10.6000 | 1 | 1 |
Glucocorticoid receptor | Homo sapiens (human) | Ki | 4.8180 | 1 | 1 |
glucose-6-phosphate 1-dehydrogenase isoform b | Homo sapiens (human) | IC50 | 72.5000 | 1 | 1 |
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase | Plasmodium berghei | IC50 | 27.9667 | 3 | 3 |
Glutaminyl-peptide cyclotransferase | Homo sapiens (human) | IC50 | 110.0000 | 1 | 1 |
Glycine receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | IC50 | 10.6000 | 1 | 1 |
Glycine receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Ki | 4.8180 | 1 | 1 |
Glycine receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | IC50 | 10.6000 | 1 | 1 |
Glycine receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Ki | 4.8180 | 1 | 1 |
Glycine receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | IC50 | 10.6000 | 1 | 1 |
Glycine receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Ki | 4.8180 | 1 | 1 |
Glycine receptor subunit beta | Rattus norvegicus (Norway rat) | IC50 | 10.6000 | 1 | 1 |
Glycine receptor subunit beta | Rattus norvegicus (Norway rat) | Ki | 4.8180 | 1 | 1 |
high affinity choline transporter 1 isoform a | Homo sapiens (human) | IC50 | 12.5893 | 1 | 1 |
Histamine H1 receptor | Homo sapiens (human) | IC50 | 0.0160 | 1 | 1 |
Histamine H1 receptor | Homo sapiens (human) | Ki | 0.0018 | 1 | 1 |
Hypoxia-inducible factor 1-alpha | Homo sapiens (human) | IC50 | 1.0000 | 1 | 1 |
Ileal sodium/bile acid cotransporter | Homo sapiens (human) | Ki | 24.0000 | 1 | 1 |
Indoleamine 2,3-dioxygenase 1 | Homo sapiens (human) | IC50 | 46.7333 | 3 | 3 |
integrase, partial | Human immunodeficiency virus 1 | IC50 | 11.7060 | 2 | 2 |
Interleukin-2 | Mus musculus (house mouse) | IC50 | 0.0050 | 1 | 1 |
Kappa-type opioid receptor | Homo sapiens (human) | IC50 | 4.5630 | 1 | 1 |
Kappa-type opioid receptor | Homo sapiens (human) | Ki | 1.8250 | 1 | 1 |
L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase | Mycobacterium tuberculosis H37Rv | IC50 | 2,500.0000 | 1 | 1 |
Large neutral amino acids transporter small subunit 1 | Rattus norvegicus (Norway rat) | Ki | 55.0000 | 1 | 1 |
large T antigen | Betapolyomavirus macacae | IC50 | 53.8800 | 1 | 2 |
lens epithelium-derived growth factor p75 | Homo sapiens (human) | IC50 | 11.7060 | 2 | 2 |
Liver carboxylesterase 1 | Homo sapiens (human) | Ki | 1.6375 | 2 | 4 |
Low molecular weight phosphotyrosine protein phosphatase | Homo sapiens (human) | IC50 | 80.0000 | 1 | 1 |
low molecular weight phosphotyrosine protein phosphatase isoform c | Homo sapiens (human) | IC50 | 80.0000 | 1 | 1 |
Matrix metalloproteinase-9 | Homo sapiens (human) | IC50 | 5.2150 | 1 | 1 |
Metabotropic glutamate receptor 5 | Rattus norvegicus (Norway rat) | IC50 | 54.3000 | 1 | 1 |
Mitogen-activated protein kinase 14 | Homo sapiens (human) | IC50 | 38.0480 | 1 | 2 |
Mu-type opioid receptor | Homo sapiens (human) | IC50 | 5.7780 | 1 | 1 |
Mu-type opioid receptor | Mus musculus (house mouse) | IC50 | 126.0000 | 1 | 1 |
Mu-type opioid receptor | Homo sapiens (human) | Ki | 2.3450 | 1 | 1 |
Multidrug resistance-associated protein 1 | Homo sapiens (human) | IC50 | 3.5082 | 10 | 10 |
Multidrug resistance-associated protein 1 | Homo sapiens (human) | Ki | 5.0000 | 1 | 1 |
Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 6 |
Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | IC50 | 9.9720 | 1 | 2 |
Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | Ki | 2.4020 | 1 | 2 |
Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | IC50 | 1.6650 | 1 | 1 |
Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | Ki | 0.5920 | 1 | 1 |
Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | IC50 | 18.4320 | 1 | 1 |
Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | Ki | 3.9070 | 1 | 1 |
Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | IC50 | 3.2650 | 1 | 1 |
Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | Ki | 2.3460 | 1 | 1 |
Myeloperoxidase | Homo sapiens (human) | IC50 | 2.8100 | 1 | 1 |
NAD(+) hydrolase SARM1 | Homo sapiens (human) | IC50 | 145.0000 | 1 | 1 |
NAD(+) hydrolase SARM1 | Homo sapiens (human) | Ki | 70.0000 | 1 | 1 |
NADH-cytochrome b5 reductase 3 | Homo sapiens (human) | IC50 | 279.4000 | 1 | 1 |
Neutrophil cytosol factor 1 | Homo sapiens (human) | Ki | 2,000.0000 | 1 | 1 |
nonstructural protein 1 | Influenza A virus (A/California/07/2009(H1N1)) | IC50 | 17.7270 | 1 | 1 |
Nuclear receptor subfamily 1 group I member 2 | Homo sapiens (human) | IC50 | 14.6000 | 1 | 1 |
Papain | Carica papaya (papaya) | IC50 | 120.0000 | 1 | 1 |
Peptidyl-prolyl cis-trans isomerase A | Homo sapiens (human) | IC50 | 0.0252 | 12 | 12 |
Peptidyl-prolyl cis-trans isomerase A | Homo sapiens (human) | Ki | 0.0645 | 8 | 8 |
Peptidyl-prolyl cis-trans isomerase B | Homo sapiens (human) | IC50 | 0.0088 | 1 | 1 |
Peptidyl-prolyl cis-trans isomerase D | Homo sapiens (human) | IC50 | 0.0036 | 1 | 1 |
Peptidyl-prolyl cis-trans isomerase D | Homo sapiens (human) | Ki | 0.0129 | 4 | 4 |
Peptidyl-prolyl cis-trans isomerase FKBP1A | Homo sapiens (human) | Ki | 0.0200 | 1 | 1 |
Peptidyl-prolyl cis-trans isomerase FKBP1B | Homo sapiens (human) | Ki | 0.0060 | 1 | 1 |
Peptidyl-prolyl cis-trans isomerase FKBP4 | Homo sapiens (human) | IC50 | 0.0160 | 1 | 1 |
Peptidylglycine alpha-amidating monooxygenase | Rattus norvegicus (Norway rat) | Ki | 0.0060 | 1 | 1 |
Peroxisome proliferator-activated receptor alpha | Homo sapiens (human) | IC50 | 2.1084 | 6 | 7 |
Peroxisome proliferator-activated receptor delta | Homo sapiens (human) | IC50 | 0.8074 | 7 | 8 |
Peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Ki | 0.0176 | 5 | 5 |
Peroxisome proliferator-activated receptor gamma | Homo sapiens (human) | IC50 | 5.0487 | 4 | 5 |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | Mus musculus (house mouse) | IC50 | 0.5700 | 1 | 1 |
Polyphenol oxidase 2 | Agaricus bisporus | IC50 | 1,477.9692 | 12 | 13 |
Polyunsaturated fatty acid 5-lipoxygenase | Homo sapiens (human) | Ki | 0.0001 | 1 | 1 |
Polyunsaturated fatty acid lipoxygenase ALOX15 | Oryctolagus cuniculus (rabbit) | IC50 | 2.9630 | 1 | 1 |
Prolyl 4-hydroxylase subunit alpha-1 | Gallus gallus (chicken) | Ki | 14,000.0000 | 1 | 1 |
Prostaglandin G/H synthase 1 | Homo sapiens (human) | IC50 | 5.6000 | 1 | 1 |
Proteasome subunit beta type-8 | Homo sapiens (human) | IC50 | 13.0000 | 1 | 1 |
Protein kinase C alpha type | Homo sapiens (human) | Ki | 0.0096 | 3 | 3 |
Protein kinase C beta type | Homo sapiens (human) | Ki | 0.0018 | 1 | 1 |
Protein kinase C delta type | Homo sapiens (human) | Ki | 0.0008 | 1 | 1 |
Protein kinase C epsilon type | Homo sapiens (human) | Ki | 0.0004 | 1 | 1 |
Protein kinase C gamma type | Homo sapiens (human) | Ki | 0.0049 | 1 | 1 |
Protein-arginine deiminase type-4 | Homo sapiens (human) | IC50 | 8,100.0000 | 1 | 1 |
Prothrombin | Homo sapiens (human) | IC50 | 12.0000 | 1 | 1 |
putative polyprotein | | IC50 | 9.9185 | 2 | 4 |
rac GTPase-activating protein 1 isoform a | Homo sapiens (human) | IC50 | 61.0533 | 1 | 3 |
Receptor tyrosine-protein kinase erbB-2 | Homo sapiens (human) | IC50 | 41.5030 | 1 | 1 |
Receptor-type tyrosine-protein phosphatase C | Homo sapiens (human) | IC50 | 3.0000 | 1 | 1 |
Replicase polyprotein 1ab | Betacoronavirus England 1 | IC50 | 10.0000 | 1 | 2 |
Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | IC50 | 6.2886 | 4 | 7 |
Reverse transcriptase/RNaseH | Human immunodeficiency virus 1 | IC50 | 0.4550 | 1 | 1 |
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | Oryctolagus cuniculus (rabbit) | IC50 | 38.0000 | 2 | 2 |
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | Homo sapiens (human) | IC50 | 0.1830 | 1 | 1 |
Snake venom metalloproteinase BaP1 | Bothrops asper (terciopelo) | IC50 | 54.3000 | 1 | 1 |
Sodium-dependent dopamine transporter | Homo sapiens (human) | IC50 | 1.9140 | 1 | 2 |
Sodium-dependent dopamine transporter | Homo sapiens (human) | Ki | 1.5205 | 1 | 2 |
Sodium-dependent noradrenaline transporter | Homo sapiens (human) | IC50 | 10.8265 | 1 | 4 |
Sodium-dependent noradrenaline transporter | Homo sapiens (human) | Ki | 10.7372 | 1 | 4 |
Sodium-dependent serotonin transporter | Homo sapiens (human) | IC50 | 6.2483 | 1 | 3 |
Sodium-dependent serotonin transporter | Homo sapiens (human) | Ki | 3.3197 | 1 | 3 |
Sodium/bile acid cotransporter | Homo sapiens (human) | IC50 | 1.0000 | 1 | 1 |
Solute carrier family 22 member 20 | Mus musculus (house mouse) | Ki | 48.9890 | 1 | 2 |
Solute carrier family 22 member 6 | Mus musculus (house mouse) | Ki | 6.2548 | 1 | 2 |
Solute carrier organic anion transporter family member 1B1 | Homo sapiens (human) | IC50 | 0.9500 | 5 | 5 |
Solute carrier organic anion transporter family member 1B1 | Homo sapiens (human) | Ki | 0.4845 | 4 | 4 |
Solute carrier organic anion transporter family member 1B3 | Homo sapiens (human) | IC50 | 41.0000 | 2 | 2 |
Solute carrier organic anion transporter family member 1B3 | Homo sapiens (human) | Ki | 19.3000 | 2 | 2 |
Solute carrier organic anion transporter family member 2B1 | Homo sapiens (human) | IC50 | 37.0000 | 1 | 1 |
Solute carrier organic anion transporter family member 2B1 | Homo sapiens (human) | Ki | 36.0000 | 1 | 1 |
Substance-K receptor | Homo sapiens (human) | IC50 | 6.8460 | 1 | 2 |
Substance-K receptor | Homo sapiens (human) | Ki | 2.2820 | 1 | 2 |
Tat | Human immunodeficiency virus 1 | IC50 | 30.4610 | 1 | 1 |
Thromboxane-A synthase | Homo sapiens (human) | IC50 | 4.3590 | 1 | 1 |
Thyroid peroxidase | Homo sapiens (human) | IC50 | 3.3800 | 1 | 1 |
Transthyretin | Homo sapiens (human) | Ki | 0.0026 | 1 | 1 |
Tyrosinase | Homo sapiens (human) | IC50 | 4,400.0000 | 2 | 2 |
Tyrosinase | Mus musculus (house mouse) | IC50 | 137.8850 | 1 | 2 |
Tyrosine-protein kinase Fyn | Homo sapiens (human) | IC50 | 21.8817 | 1 | 3 |
Tyrosine-protein kinase Lck | Homo sapiens (human) | IC50 | 55.4520 | 1 | 1 |
Tyrosine-protein phosphatase non-receptor type 1 | Homo sapiens (human) | IC50 | 1.6400 | 1 | 1 |
Tyrosine-protein phosphatase non-receptor type 22 | Homo sapiens (human) | IC50 | 1.1000 | 1 | 1 |
tyrosyl-DNA phosphodiesterase 2 | Homo sapiens (human) | IC50 | 128.3320 | 1 | 1 |
UDP-glucose 4-epimerase | Homo sapiens (human) | IC50 | 75.0000 | 1 | 1 |
UDP-glucuronosyltransferase 1-6 | Homo sapiens (human) | IC50 | 211.8333 | 1 | 6 |
UDP-glucuronosyltransferase 1A1 | Homo sapiens (human) | IC50 | 211.8333 | 1 | 6 |
UDP-glucuronosyltransferase 1A4 | Homo sapiens (human) | IC50 | 211.8333 | 1 | 6 |
UDP-glucuronosyltransferase 2B10 | Homo sapiens (human) | IC50 | 211.8333 | 1 | 6 |
UDP-glucuronosyltransferase 2B7 | Homo sapiens (human) | IC50 | 211.8333 | 1 | 6 |
Vasopressin V1a receptor | Homo sapiens (human) | IC50 | 25.9250 | 1 | 1 |
Vasopressin V1a receptor | Homo sapiens (human) | Ki | 10.4010 | 1 | 1 |
Vif | Human immunodeficiency virus 1 | IC50 | 10.6100 | 1 | 1 |
Voltage-dependent calcium channel subunit alpha-2/delta-1 | Mus musculus (house mouse) | Ki | 0.1024 | 1 | 2 |