Any substance which is used to reduce or control weight.
| Member | Definition | Class |
|---|
| 1-deoxynojirimycin | An optically active form of 2-(hydroxymethyl)piperidine-3,4,5-triol having 2R,3R,4R,5S-configuration. | duvoglustat |
| as 1842856 | A quinolone that is 4-quinolone substituted at positions 1, 3, 5, 6 and 7 by ethyl, carboxy, amino, fluorine, and cyclohexylamino groups, respectively. It can directly bind to and block the transcription activity of the active forkhead box protein O1 (Foxo1), but not the Ser256-phosphorylated form. It induces cell death and growth arrest in Burkitt lymphoma cell lines at low concentrations. | AS1842856 |
| chromium tripicolinate | | tris(picolinato)chromium |
| ginsenoside rb1 | A ginsenoside found in Panax ginseng and Panax japonicus var. major that is ginsenoside Rd in which the beta-D-glucopyranoside group at position 20 is replaced by a beta-D-glucopyranosyl-beta-D-glucopyranoside group. | ginsenoside Rb1 |
| lorcaserin | A benzazepine that is 2,3,4,5-tetrahydro-3-benzazepine substituted at position 1 by a methyl group and a t position 6 by a chloro group. | lorcaserin |
| orlistat | A carboxylic ester resulting from the formal condensation of the carboxy group of N-formyl-L-leucine with the hydroxy group of (3S,4S)-3-hexyl-4-[(2S)-2-hydroxytridecyl]oxetan-2-one. A pancreatic lipase inhibitor, it is used as an anti-obesity drug. | orlistat |
| resolvin d2 | A member of the class of resolvins that is (4Z,8E,10Z,12E,14E,19Z)-docosahexaenoic acid carrying three hydroxy substituents at positions 7, 16 and 17 (the 7S,16R,17S-stereoisomer). | resolvin D2 |
| semaglutide | A polypeptide that contains a linear sequence of 31 amino acids joined together by peptide linkages. It is an agonist of glucagon-like peptide-1 receptors (GLP-1 AR) and used for the treatment of type 2 diabetes. | semaglutide |
| sibutramine | | sibutramine |
| sigmoidin a | A tetrahydroxyflavanone that is (2S)-flavanone substituted by hydroxy groups at positions 5, 7, 3' and 4' and prenyl groups at positions 2' and 5'. Isolated from Erythrina sigmoidea, it exhibits anti-inflammatory and antioxidant activities. | sigmoidin A |
| sr141716 | A carbohydrazide obtained by formal condensation of the carboxy group of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid with the amino group of 1-aminopiperidine. It is a potent and selective cannabinoid receptor 1 (CB1R) antagonist. Besides its antagonistic properties, numerous studies have shown that, at micromolar concentrations rimonabant behaves as an inverse agonist at CB1 receptors. The drug was the first selective CB1 antagonist/inverse agonist introduced into clinical practice to treat obesity and metabolic-related disorders. It was later withdrawn from market due to CNS-related adverse effects including depression and suicidal ideation. | rimonabant |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| acetylcholinesterase | Homo sapiens (human) | Potency | 2.5701 | 3 | 3 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 3.3780 | 1 | 1 |
| alpha-galactosidase | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 20.3624 | 7 | 10 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 20.4600 | 2 | 4 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 50.1187 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 66.8968 | 1 | 2 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 13.6497 | 1 | 2 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 7.1258 | 1 | 2 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 6.2809 | 1 | 3 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 7.5193 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 15.0599 | 4 | 8 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 5.5588 | 1 | 2 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 16.2971 | 6 | 6 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 27.7368 | 4 | 8 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 33.4889 | 1 | 1 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 27.0680 | 1 | 2 |
| G | Vesicular stomatitis virus | Potency | 13.6497 | 1 | 2 |
| geminin | Homo sapiens (human) | Potency | 4.8800 | 2 | 3 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 15.7792 | 2 | 3 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 20.8802 | 2 | 3 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 47.1364 | 1 | 2 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 13.6497 | 1 | 2 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 26.8325 | 1 | 1 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 13.6497 | 1 | 4 |
| Interferon beta | Homo sapiens (human) | Potency | 21.9892 | 2 | 8 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 0.0009 | 1 | 1 |
| lysosomal alpha-glucosidase preproprotein | Homo sapiens (human) | Potency | 0.0580 | 5 | 5 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 13.2335 | 2 | 3 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 9.5205 | 1 | 1 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 18.5216 | 2 | 2 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 18.1056 | 1 | 1 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 9.2022 | 3 | 4 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 33.4889 | 1 | 1 |
| polyprotein | Zika virus | Potency | 27.0680 | 1 | 2 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 2.8184 | 1 | 1 |
| PPM1D protein | Homo sapiens (human) | Potency | 24.7690 | 1 | 4 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 33.4915 | 1 | 1 |
| progesterone receptor | Homo sapiens (human) | Potency | 6.8833 | 1 | 2 |
| Rap guanine nucleotide exchange factor 3 | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 24.1084 | 2 | 4 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 31.0634 | 3 | 3 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 16.1998 | 2 | 2 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 3.9811 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 20.0406 | 2 | 6 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 12.2352 | 2 | 2 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 42.2090 | 2 | 2 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 25.2704 | 2 | 2 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| Vpr | Human immunodeficiency virus 1 | Potency | 31.6228 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | Ki | 0.6212 | 5 | 5 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | Ki | 0.1517 | 5 | 5 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | Ki | 0.0713 | 7 | 7 |
| Acyl-protein thioesterase 2 | Rattus norvegicus (Norway rat) | IC50 | 0.1700 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | IC50 | 5.6650 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | Ki | 5.6190 | 1 | 1 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 1.3000 | 1 | 1 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 1.3000 | 1 | 1 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 1.3000 | 1 | 1 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | IC50 | 2.3900 | 1 | 1 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | Ki | 1.0910 | 1 | 1 |
| Alpha-amylase | Geobacillus stearothermophilus | IC50 | 1.6700 | 1 | 1 |
| Alpha-galactosidase A | Homo sapiens (human) | Ki | 18.0000 | 1 | 1 |
| Alpha-glucosidase MAL12 | Saccharomyces cerevisiae S288C | IC50 | 278.0000 | 1 | 1 |
| Alpha-glucosidase MAL12 | Saccharomyces cerevisiae S288C | Ki | 18.0000 | 1 | 1 |
| Alpha-glucosidase MAL32 | Saccharomyces cerevisiae S288C | IC50 | 175.0000 | 1 | 2 |
| Alpha-glucosidase MAL62 | Saccharomyces cerevisiae (brewer's yeast) | IC50 | 212,855.0000 | 2 | 2 |
| Alpha-mannosidase | Canavalia ensiformis (jack bean) | Ki | 270.0000 | 1 | 1 |
| Alpha-mannosidase 2 | Rattus norvegicus (Norway rat) | Ki | 50.0000 | 1 | 1 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| Beta-glucosidase | Agrobacterium tumefaciens | Ki | 12.0000 | 2 | 2 |
| Beta-glucosidase | Prunus avium (sweet cherry) | IC50 | 81.0000 | 1 | 1 |
| Beta-glucosidase A | Caldicellulosiruptor saccharolyticus | IC50 | 218.3333 | 3 | 3 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 56.0000 | 2 | 3 |
| C-X-C chemokine receptor type 3 | Homo sapiens (human) | Ki | 0.0016 | 1 | 1 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| Cannabinoid receptor 1 | Homo sapiens (human) | IC50 | 0.0244 | 32 | 32 |
| Cannabinoid receptor 1 | Mus musculus (house mouse) | IC50 | 0.0250 | 1 | 1 |
| Cannabinoid receptor 1 | Rattus norvegicus (Norway rat) | IC50 | 0.0081 | 3 | 3 |
| Cannabinoid receptor 1 | Homo sapiens (human) | Ki | 0.0739 | 80 | 84 |
| Cannabinoid receptor 1 | Mus musculus (house mouse) | Ki | 0.0062 | 2 | 2 |
| Cannabinoid receptor 1 | Rattus norvegicus (Norway rat) | Ki | 0.0046 | 8 | 11 |
| Cannabinoid receptor 2 | Homo sapiens (human) | IC50 | 2.3894 | 19 | 19 |
| Cannabinoid receptor 2 | Homo sapiens (human) | Ki | 1.9157 | 47 | 50 |
| Cathepsin B | Mus musculus (house mouse) | Ki | 1.5800 | 1 | 1 |
| Ceramide glucosyltransferase | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Cytochrome P450 2C19 | Homo sapiens (human) | IC50 | 0.2134 | 2 | 2 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 0.2134 | 2 | 2 |
| Cytosolic beta-glucosidase | Homo sapiens (human) | IC50 | 160.0000 | 2 | 2 |
| Delta-type opioid receptor | Mus musculus (house mouse) | IC50 | 14.4000 | 1 | 1 |
| Diacylglycerol lipase-alpha | Homo sapiens (human) | IC50 | 0.2678 | 4 | 4 |
| Diacylglycerol lipase-alpha | Mus musculus (house mouse) | IC50 | 0.0200 | 1 | 1 |
| Diacylglycerol lipase-beta | Homo sapiens (human) | IC50 | 0.2400 | 2 | 2 |
| DNA topoisomerase 1 | Homo sapiens (human) | IC50 | 250.0000 | 1 | 1 |
| DNA topoisomerase 2-alpha | Homo sapiens (human) | IC50 | 250.0000 | 1 | 1 |
| Endothelial lipase | Homo sapiens (human) | IC50 | 0.0060 | 1 | 1 |
| Fatty acid synthase | Homo sapiens (human) | IC50 | 69.6600 | 3 | 3 |
| Fatty acid synthase | Homo sapiens (human) | Ki | 0.2800 | 1 | 1 |
| Fatty acid-binding protein, liver | Mus musculus (house mouse) | Ki | 2.0000 | 1 | 1 |
| Fatty-acid amide hydrolase 1 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Fatty-acid amide hydrolase 1 | Rattus norvegicus (Norway rat) | IC50 | 0.0100 | 1 | 1 |
| Forkhead box protein O1 | Homo sapiens (human) | IC50 | 0.0330 | 1 | 1 |
| G-protein coupled bile acid receptor 1 | Homo sapiens (human) | Ki | 0.9000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 1 | Rattus norvegicus (Norway rat) | Ki | 0.0250 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2A | Rattus norvegicus (Norway rat) | Ki | 0.0250 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2B | Rattus norvegicus (Norway rat) | Ki | 0.0250 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2C | Rattus norvegicus (Norway rat) | Ki | 0.0250 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2D | Rattus norvegicus (Norway rat) | Ki | 0.0250 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3A | Rattus norvegicus (Norway rat) | Ki | 0.0250 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3B | Rattus norvegicus (Norway rat) | Ki | 0.0250 | 1 | 1 |
| Glycogen debranching enzyme | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Glycogen debranching enzyme | Oryctolagus cuniculus (rabbit) | IC50 | 0.1900 | 1 | 1 |
| Hepatic triacylglycerol lipase | Homo sapiens (human) | IC50 | 0.0030 | 1 | 1 |
| Kappa-type opioid receptor | Cavia porcellus (domestic guinea pig) | IC50 | 250.0000 | 1 | 1 |
| Kappa-type opioid receptor | Mus musculus (house mouse) | IC50 | 0.1903 | 1 | 2 |
| Lactase-phlorizin hydrolase | Homo sapiens (human) | IC50 | 62.0000 | 1 | 1 |
| Lactase-phlorizin hydrolase | Rattus norvegicus (Norway rat) | IC50 | 36.3333 | 3 | 3 |
| Lipoprotein lipase | Homo sapiens (human) | IC50 | 0.0660 | 1 | 1 |
| Lysophosphatidylserine lipase ABHD12 | Homo sapiens (human) | IC50 | 0.1682 | 3 | 5 |
| Lysosomal acid glucosylceramidase | Bos taurus (cattle) | IC50 | 210.0000 | 1 | 1 |
| Lysosomal acid glucosylceramidase | Homo sapiens (human) | IC50 | 280.3333 | 6 | 6 |
| Lysosomal acid glucosylceramidase | Homo sapiens (human) | Ki | 68.3333 | 3 | 3 |
| Lysosomal alpha-glucosidase | Homo sapiens (human) | IC50 | 39.2600 | 6 | 6 |
| Lysosomal alpha-glucosidase | Rattus norvegicus (Norway rat) | IC50 | 0.3125 | 4 | 4 |
| Lysosomal alpha-glucosidase | Homo sapiens (human) | Ki | 12.5295 | 2 | 2 |
| Maltase-glucoamylase, intestinal | Homo sapiens (human) | IC50 | 34.7614 | 7 | 7 |
| Monoacylglycerol lipase ABHD6 | Homo sapiens (human) | IC50 | 0.0300 | 5 | 6 |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | IC50 | 0.1080 | 1 | 1 |
| Multidrug resistance-associated protein 1 | Homo sapiens (human) | Ki | 1.4000 | 1 | 1 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | Ki | 4.0000 | 1 | 1 |
| N-arachidonyl glycine receptor | Homo sapiens (human) | IC50 | 10.1000 | 1 | 1 |
| Neutral alpha-glucosidase AB | Homo sapiens (human) | IC50 | 472.8250 | 3 | 4 |
| Neutral alpha-glucosidase AB | Homo sapiens (human) | Ki | 410.0000 | 1 | 1 |
| Neutral cholesterol ester hydrolase 1 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Non-lysosomal glucosylceramidase | Homo sapiens (human) | IC50 | 24.9500 | 4 | 4 |
| Oligo-1,6-glucosidase IMA1 | Saccharomyces cerevisiae S288C | IC50 | 330.0000 | 1 | 1 |
| Oxysterols receptor LXR-alpha | Homo sapiens (human) | IC50 | 137.5000 | 3 | 4 |
| Oxysterols receptor LXR-beta | Homo sapiens (human) | IC50 | 150.0000 | 2 | 3 |
| Pancreatic triacylglycerol lipase | Homo sapiens (human) | IC50 | 0.3253 | 3 | 3 |
| Pancreatic triacylglycerol lipase | Sus scrofa (pig) | IC50 | 0.4214 | 14 | 14 |
| Pancreatic triacylglycerol lipase | Sus scrofa (pig) | Ki | 5.0300 | 2 | 2 |
| Phosphatidylserine lipase ABHD16A | Homo sapiens (human) | IC50 | 0.1000 | 2 | 2 |
| Platelet-activating factor acetylhydrolase | Homo sapiens (human) | IC50 | 0.0500 | 1 | 1 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | IC50 | 3.7950 | 2 | 2 |
| Probable maltase-glucoamylase 2 | Homo sapiens (human) | IC50 | 115.7500 | 2 | 2 |
| Proteasome subunit beta type-1 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Proteasome subunit beta type-2 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Proteasome subunit beta type-5 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Protein-lysine 6-oxidase | Homo sapiens (human) | IC50 | 1.0000 | 1 | 1 |
| Protein-lysine 6-oxidase | Homo sapiens (human) | Ki | 79.0000 | 1 | 1 |
| Putative alpha-glucosidase | Oryza sativa Japonica Group (Japanese rice) | IC50 | 0.0400 | 2 | 2 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | IC50 | 0.6320 | 1 | 1 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | Ki | 5.2510 | 2 | 2 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | IC50 | 5.6650 | 1 | 1 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | Ki | 7.8095 | 2 | 2 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | IC50 | 2.0850 | 1 | 1 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | Ki | 1.8570 | 2 | 2 |
| Sucrase-isomaltase, intestinal | Homo sapiens (human) | IC50 | 77.8333 | 3 | 3 |
| Sucrase-isomaltase, intestinal | Rattus norvegicus (Norway rat) | IC50 | 0.3479 | 14 | 14 |
| Translocator protein | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 1 |
| Trehalase | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| Trehalase | Rattus norvegicus (Norway rat) | IC50 | 41.6667 | 3 | 3 |
| Trehalase | Sus scrofa (pig) | IC50 | 41.0000 | 2 | 2 |
| Trehalose synthase/amylase TreS | Mycobacterium tuberculosis CDC1551 | Ki | 0.2500 | 1 | 1 |
| Tyrosine-protein phosphatase non-receptor type 1 | Homo sapiens (human) | IC50 | 14.4000 | 1 | 1 |