Page last updated: 2024-11-12

5-Hydroxyauranetin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

5-hydroxy-3,6,7,8,4'-pentamethoxyflavone: has diuretic activity; isolated from Rubus rosaefolius [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID11079623
CHEMBL ID504047
CHEBI ID175931
SCHEMBL ID4066374

Synonyms (13)

Synonym
MEGXP0_001194
5-hydroxy-3,6,7,8-tetramethoxy-2-(4-methoxyphenyl)chromen-4-one
CHEMBL504047
5-hydroxyauranetin
LMPK12113314
5-hydroxy-3,6,7,8,4'-pentamethoxyflavone
SCHEMBL4066374
5-hydroxy-3,6,7,8-tetramethoxy-2-(4-methoxyphenyl)-4h-1-benzopyran-4-one
4'-o-methylcalycopterin
5-hydroxy-3,4',6,7,8-pentamethoxyflavone
50439-46-8
CHEBI:175931
DTXSID501150275
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (2)

ClassDescription
flavonoidsAny organic molecular entity whose stucture is based on derivatives of a phenyl-substituted 1-phenylpropane possessing a C15 or C16 skeleton, or such a structure which is condensed with a C6-C3 lignan precursors. The term is a 'superclass' comprising all members of the classes of flavonoid, isoflavonoid, neoflavonoid, chalcones, dihydrochalcones, aurones, pterocarpan, coumestans, rotenoid, flavonolignan, homoflavonoid and flavonoid oligomers. Originally restricted to natural products, the term is also applied to synthetic compounds related to them.
etherAn organooxygen compound with formula ROR, where R is not hydrogen.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (14)

Assay IDTitleYearJournalArticle
AID1100871Antifeedant activity against Spodoptera litura in compound treated cork borer from fresh sweet potato leaves by Choice Leaf-Disk Bioassay2000Journal of agricultural and food chemistry, May, Volume: 48, Issue:5
Insect antifeedant flavonoids from Gnaphalium affine D. Don.
AID761699Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay2013European journal of medicinal chemistry, Aug, Volume: 66Selective cytotoxic effects on human breast carcinoma of new methoxylated flavonoids from Euryops arabicus grown in Saudi Arabia.
AID1103947Antifeedant activity against third-instar Spodoptera litura assessed per cm2 leaf disk2009Bioresource technology, Jul, Volume: 100, Issue:14
Antifeedant activity of ethanolic extract from Flourensia oolepis and isolation of pinocembrin as its active principle compound.
AID761701Antiproliferative activity against african green monkey Vero cells after 48 hrs by MTT assay2013European journal of medicinal chemistry, Aug, Volume: 66Selective cytotoxic effects on human breast carcinoma of new methoxylated flavonoids from Euryops arabicus grown in Saudi Arabia.
AID761702Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay2013European journal of medicinal chemistry, Aug, Volume: 66Selective cytotoxic effects on human breast carcinoma of new methoxylated flavonoids from Euryops arabicus grown in Saudi Arabia.
AID552376Cytotoxicity against human KB cells after 72 hrs by MTS assay2011Bioorganic & medicinal chemistry, Jan-01, Volume: 19, Issue:1
Synthesis of antiproliferative flavones from calycopterin, major flavonoid of Calycopteris floribunda Lamk.
AID1102050Antifeedant activity against Spodoptera litura F. by choice leaf disk assay2003Journal of agricultural and food chemistry, Jan-15, Volume: 51, Issue:2
Insect antifeedant activity of flavones and chromones against Spodoptera litura.
AID552382Inhibition of sheep brain tubulin polymerization after 5 mins2011Bioorganic & medicinal chemistry, Jan-01, Volume: 19, Issue:1
Synthesis of antiproliferative flavones from calycopterin, major flavonoid of Calycopteris floribunda Lamk.
AID761700Antiproliferative activity against human WI38 cells after 48 hrs by MTT assay2013European journal of medicinal chemistry, Aug, Volume: 66Selective cytotoxic effects on human breast carcinoma of new methoxylated flavonoids from Euryops arabicus grown in Saudi Arabia.
AID761703Immunostimulant activity in PHA-stimulated human PBL assessed as lymphocyte transformation at 2 mM after 72 hrs by Giemsa staining method2013European journal of medicinal chemistry, Aug, Volume: 66Selective cytotoxic effects on human breast carcinoma of new methoxylated flavonoids from Euryops arabicus grown in Saudi Arabia.
AID552377Cytotoxicity against human KB cells at 10'-6 M after 72 hrs by MTS assay2011Bioorganic & medicinal chemistry, Jan-01, Volume: 19, Issue:1
Synthesis of antiproliferative flavones from calycopterin, major flavonoid of Calycopteris floribunda Lamk.
AID381260Cytotoxicity against human KB cells
AID761704Antioxidant activity assessed as ABTS free radical scavenging activity by spectrophotometry2013European journal of medicinal chemistry, Aug, Volume: 66Selective cytotoxic effects on human breast carcinoma of new methoxylated flavonoids from Euryops arabicus grown in Saudi Arabia.
AID552374Induction of apoptosis in human HL60 cells assessed as induction of caspase 3/7 activation at 100 uM relative to control2011Bioorganic & medicinal chemistry, Jan-01, Volume: 19, Issue:1
Synthesis of antiproliferative flavones from calycopterin, major flavonoid of Calycopteris floribunda Lamk.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (60.00)29.6817
2010's2 (40.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.72

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.72 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.66 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.72)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]