Compounds > gentamicin c1a
Page last updated: 2024-12-06

gentamicin c1a

Cross-References

ID SourceID
PubMed CID72396
CHEMBL ID194126
CHEBI ID27784
SCHEMBL ID66939
MeSH IDM0327283

Synonyms (36)

Synonym
CHEMBL194126
gentamycin c1a
(1r,2s,3s,4r,6s)-4,6-diamino-3-[3-deoxy-4-c-methyl-3-(methylamino)-beta-l-arabinopyranosyloxy]-2-hydroxycyclohexyl 2,6-diamino-2,3,4,6-tetradeoxy-alpha-d-erythro-hexopyranoside
CHEBI:27784 ,
(2r,3r,4r,5r)-2-((1s,2s,3r,4s,6r)-4,6-diamino-3-((2r,3r,6s)-3-amino-6-(aminomethyl)-tetrahydro-2h-pyran-2-yloxy)-2-hydroxycyclohexyloxy)-5-methyl-4-(methylamino)-tetrahydro-2h-pyran-3,5-diol
gentamycin c12
o-3-deoxy-4-c-methyl-3-(methylamino)-beta-l-arabinopyranosyl-(1-6)-o-(2,6-diamino-2,3,4,6-tetradeoxy-alpha-d-erythro-hexopyranosyl-(1-4))-2-deoxy-d-streptamine
(2r,3r,4r,5r)-2-[(1s,2s,3r,4s,6r)-4,6-diamino-3-[(2r,3r,6s)-3-amino-6-(aminomethyl)tetrahydropyran-2-yl]oxy-2-hydroxy-cyclohexoxy]-5-methyl-4-(methylamino)tetrahydropyran-3,5-diol
(1r,2s,3s,4r,6s)-4,6-diamino-3-{[3-deoxy-4-c-methyl-3-(methylamino)-beta-l-arabinopyranosyl]oxy}-2-hydroxycyclohexyl 2,6-diamino-2,3,4,6-tetradeoxy-alpha-d-erythro-hexopyranoside
nsc82261
tlc g-65
gentocin (*sulfate*)
garamycin (*sulfate*)
liposomal gentamicin
septocin
C00908
gentamicin c1a
26098-04-4
(2r,3r,4r,5r)-2-((1s,2s,3r,4s,6r)-4,6-diamino-3-((2r,3r,6s)-3-amino-6-(aminomethyl)-tetrahydro-2h-pyran-2-yloxy)-2-hydr oxycyclohexyloxy)-5-methyl-4-(methylamino)-tetrahydro-2h-pyran-3,5-diol
DB04729
brn 1356351
d-streptamine, o-3-deoxy-4-c-methyl-3-(methylamino)-beta-l-arabinopyranosyl-(1-6)-o-(2,6-diamino-2,3,4,6-tetradeoxy-alpha-d-erythro-hexopyranosyl-(1-4))-2-deoxy-
(2r,3r,4r,5r)-2-[(1s,2s,3r,4s,6r)-4,6-diamino-3-[(2r,3r,6s)-3-amino-6-(aminomethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol
av4a72iatd ,
unii-av4a72iatd
SCHEMBL66939
d-streptamine, o-3-deoxy-4-c-methyl-3-(methylamino)-.beta.-l-arabinopyranosyl-(1->6)-o-(2,6-diamino-2,3,4,6-tetradeoxy-.alpha.-d-erythro-hexopyranosyl-(1->4))-2-deoxy-
gentamicin c1a [mi]
DTXSID4023092
J-016253
(2r,3r,4r,5r)-2-((1s,2s,3r,4s,6r)-4,6-diamino-3-((2r,3r,6s)-3-amino-6-(aminomethyl)-tetrahydro-2h-pyran-2-yloxy)-2-hydr
oxycyclohexyloxy)-5-methyl-4-(methylamino)-tetrahydro-2h-pyran-3,5-diol
Q27095468
d-streptamine, o-3-deoxy-4-c-methyl-3-(methylamino)-beta-l-arabinopyranosyl-(1-->6)-o-[2,6-diamino-2,3,4,6-tetradeoxy-alpha-d-erythro-hexopyranosyl-(1-->4)]-2-deoxy-
HY-148286
CS-0618278

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" Many of the new compounds possessed equal or better antimicrobial potency compared to polymyxin B, and some were less toxic than polymyxin B and colistin against mammalian HepG2 cells and human primary kidney cells."( Activity and Predicted Nephrotoxicity of Synthetic Antibiotics Based on Polymyxin B.
Becker, B; Blaskovich, MA; Butler, MS; Cooper, MA; Elliott, AG; Gallardo-Godoy, A; Huang, JX; Kavanagh, AM; Lash, LH; Muldoon, C; Pelingon, R; Phetsang, W; Ramu, S, 2016)		0.43
" The full repertoire of cellular targets and processes leading to the toxicity of aminoglycosides is not fully resolved, making it challenging to devise rational directions to circumvent their adverse effects."( The relationship between the structure and toxicity of aminoglycoside antibiotics.
Fridman, M; Jospe-Kaufman, M; Siomin, L, 2020)		0.56

Bioavailability

ExcerptReferenceRelevance
" Consequently, compound 10 was orally bioavailable with a highly-acceptable pharmacokinetic profile in vivo that exhibited a half-life of 4 h and achieved a maximum plasma concentration that exceeded the minimum inhibitory concentration (MIC) values against all tested bacterial isolates."( Phenylthiazoles with nitrogenous side chain: An approach to overcome molecular obesity.
Abutaleb, NS; Elsebaei, MM; Hagras, M; Li, D; Mahgoub, AA; Mayhoub, AS; Mohammad, H; Seleem, MN, 2019)		0.51
" Two modified melittin peptides displayed rapid bactericidal properties against antibiotic-resistant strains, low innate resistance development by pathogenic bacteria, remained nonimmunogenic for T lymphocytes, and increased bioavailability in tear fluids."( Rational Substitution of ε-Lysine for α-Lysine Enhances the Cell and Membrane Selectivity of Pore-Forming Melittin.
Agrawal, R; Barathi, VA; Beuerman, RW; Chan, LW; Jie, TY; Koh, SK; Lakshminarayanan, R; Leng, ET; Mayandi, V; Sebastian, TM; Somaraju Chalasani, ML; Ting, DSJ; Urf Turabe Fazil, MH; Varadarajan, J; Verma, NK; Xi, Q; Zhou, L, 2020)		0.56
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
gentamycin C
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (681)

Assay IDTitleYearJournalArticle
AID1809598Antibacterial activity against Corynebacterium ATCC 49368 assessed as zone of inhibition at 10 mg/ml2021Bioorganic & medicinal chemistry letters, 11-15, Volume: 52Synthesis, anti-microbial, toxicity and molecular docking studies of N-nitroso-N-phenylhydroxylamine (cupferron) and its derivatives.
AID1416413Antibacterial activity against Escherichia coli incubated for 24 hrs by microdilution method2017MedChemComm, Aug-01, Volume: 8, Issue:8
Synthesis and molecular docking studies of xanthone attached amino acids as potential antimicrobial and anti-inflammatory agents.
AID1282498Antibacterial activity against Acinetobacter baumannii ATCC 19606 after 18 hrs by 2 fold serial dilution method2016Journal of medicinal chemistry, Feb-11, Volume: 59, Issue:3
Activity and Predicted Nephrotoxicity of Synthetic Antibiotics Based on Polymyxin B.
AID1540927Effect on growth of Lactobacillus gasseri EX336960VC03 HM 400 measured after 48 hrs in anaerobic conditions by CLSI method
AID1592957Antibacterial activity against multi-drug resistant Escherichia coli NMI 3548/14 assessed as reduction in microbial growth incubated for 20 hrs2019European journal of medicinal chemistry, Apr-15, Volume: 168Microwave-assisted solid-phase synthesis of antisense acpP peptide nucleic acid-peptide conjugates active against colistin- and tigecycline-resistant E. coli and K. pneumoniae.
AID1677473Antibacterial activity against Bacillus cereus2020Bioorganic & medicinal chemistry letters, 11-01, Volume: 30, Issue:21
New antibacterial cadiolide analogues active against antibiotic-resistant strains.
AID1809591Antibacterial activity against Streptococcus pyogenes ATCC 19615 assessed as zone of inhibition at 5 mg/ml2021Bioorganic & medicinal chemistry letters, 11-15, Volume: 52Synthesis, anti-microbial, toxicity and molecular docking studies of N-nitroso-N-phenylhydroxylamine (cupferron) and its derivatives.
AID1282500Antibacterial activity against clinical isolate polymyxin resistant Pseudomonas aeruginosa FADDI-PA070 after 18 hrs by 2 fold serial dilution method2016Journal of medicinal chemistry, Feb-11, Volume: 59, Issue:3
Activity and Predicted Nephrotoxicity of Synthetic Antibiotics Based on Polymyxin B.
AID1356832Antimicrobial activity against Klebsiella pneumoniae NCTC 13442 by broth microdilution method2018Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
Total Synthesis and Structure-Activity Relationships Study of Odilorhabdins, a New Class of Peptides Showing Potent Antibacterial Activity.
AID1435679Antibacterial activity against Escherichia coli ATCC 8739 after 24 hrs by broth microdilution method2017European journal of medicinal chemistry, Jan-27, Volume: 126S-substituted 3,5-dinitrophenyl 1,3,4-oxadiazole-2-thiols and tetrazole-5-thiols as highly efficient antitubercular agents.
AID1311805Antibacterial activity against Acinetobacter baumannii B5W71 ATCC 15149 by two fold serial dilution method2016Bioorganic & medicinal chemistry, 09-15, Volume: 24, Issue:18
Antibacterial and anticancer activity of a series of novel peptides incorporating cyclic tetra-substituted C(α) amino acids.
AID1271798Antibacterial activity against Escherichia coli ATCC 10536 after 24 hrs by broth microdilution method2016Bioorganic & medicinal chemistry letters, Jan-15, Volume: 26, Issue:2
Synthesis, antibacterial and cytotoxic activities of new biflorin-based hydrazones and oximes.
AID1591937Antibacterial activity against Pseudomonas aeruginosa by CLSI guideline based broth microdilution method2019Journal of natural products, 08-23, Volume: 82, Issue:8
Mallopenins A-E, Antibacterial Phenolic Derivatives from the Fruits of
AID1442092Antibacterial activity against ceftazidime-resistant Pseudomonas aeruginosa 11431 after 18 hrs by broth microdilution method2017Journal of medicinal chemistry, 03-23, Volume: 60, Issue:6
Novel Design of Heptad Amphiphiles To Enhance Cell Selectivity, Salt Resistance, Antibiofilm Properties and Their Membrane-Disruptive Mechanism.
AID1447478Antibacterial activity against Pseudomonas aeruginosa PAO1 after 18 hrs by microtiter dilution assay2017Journal of medicinal chemistry, 05-11, Volume: 60, Issue:9
Amphiphilic Tobramycin-Lysine Conjugates Sensitize Multidrug Resistant Gram-Negative Bacteria to Rifampicin and Minocycline.
AID1577333Antimycobacterial activity against multi-drug resistant Mycobacterium tuberculosis 9449/2007 after 21 days2019Journal of medicinal chemistry, 09-12, Volume: 62, Issue:17
Development of 3,5-Dinitrophenyl-Containing 1,2,4-Triazoles and Their Trifluoromethyl Analogues as Highly Efficient Antitubercular Agents Inhibiting Decaprenylphosphoryl-β-d-ribofuranose 2'-Oxidase.
AID1870159Antibacterial activity against wild type Staphylococcus aureus 78/CF assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay2022Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14
LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials.
AID1296385Antimycobacterial activity against multi drug resistant Mycobacterium tuberculosis 8666/2010 after 14 days by microdilution method2016Journal of medicinal chemistry, Mar-24, Volume: 59, Issue:6
Development of 3,5-Dinitrobenzylsulfanyl-1,3,4-oxadiazoles and Thiadiazoles as Selective Antitubercular Agents Active Against Replicating and Nonreplicating Mycobacterium tuberculosis.
AID1435654Antimycobacterial activity against multidrug-resistant Mycobacterium tuberculosis 8666/2010 after 14 days by micromethod2017European journal of medicinal chemistry, Jan-27, Volume: 126S-substituted 3,5-dinitrophenyl 1,3,4-oxadiazole-2-thiols and tetrazole-5-thiols as highly efficient antitubercular agents.
AID1318919Antibacterial activity against multidrug/extremely drug-resistant/colistin-susceptible Pseudomonas aeruginosa isolate 1018852016Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
Hybrid Antibiotic Overcomes Resistance in P. aeruginosa by Enhancing Outer Membrane Penetration and Reducing Efflux.
AID1616732Antiproliferative activity against human U87MG cells assessed as reduction in cell viability after 72 hrs by SRB assay
AID1497850Antibacterial activity against Staphylococcus aureus ATCC 29737 assessed as diameter of inhibition zone at 200 ug per disc after 24 hrs by agar disc diffusion method2018Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12
Design, synthesis and biological evaluation of benzofuran appended benzothiazepine derivatives as inhibitors of butyrylcholinesterase and antimicrobial agents.
AID1870142Antibacterial activity against wild type Staphylococcus aureus 4904/C assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay2022Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14
LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials.
AID1435653Antimycobacterial activity against multidrug-resistant Mycobacterium tuberculosis 7357/1998 after 14 days by micromethod2017European journal of medicinal chemistry, Jan-27, Volume: 126S-substituted 3,5-dinitrophenyl 1,3,4-oxadiazole-2-thiols and tetrazole-5-thiols as highly efficient antitubercular agents.
AID1878471Antibacterial activity against Escherichia coli ATCC 25922 assessed as inhibition of bacterial growth incubated for 90 mins by serial dilution assay2022European journal of medicinal chemistry, Mar-05, Volume: 231Systematic comparison of activity and mechanism of antimicrobial peptides against nosocomial pathogens.
AID1713882Antibacterial activity against methicillin-resistant Staphylococcus aureus CEMTC 1695 assessed as bacterial growth inhibition by CLSI protocol based serial microdilution method2016Bioorganic & medicinal chemistry, 11-15, Volume: 24, Issue:22
Biological evaluation of tetracationic compounds based on two 1,4-diazabicyclo[2.2.2]octane moieties connected by different linkers.
AID1369485Antibacterial activity against Escherichia coli ATCC 25922 after 18 hrs in presence of 25% human heat-inactivated serum by broth dilution method2018Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides.
AID1391490Antibacterial activity against Escherichia coli assessed as diameter of inhibition zone measured after 24 hrs by agar well diffusion method
AID1265197Antibacterial activity against Bacillus subtilis ATCC 6633 after 24 hrs by microtiter plate method2015Bioorganic & medicinal chemistry letters, Dec-15, Volume: 25, Issue:24
Synthesis, biological activity evaluation and molecular docking studies of novel coumarin substituted thiazolyl-3-aryl-pyrazole-4-carbaldehydes.
AID1322258Antibacterial activity against ANT2''-IA expressing Escherichia coli L8058.1 by microdilution method2016Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20
New Broad-Spectrum Antibacterial Amphiphilic Aminoglycosides Active against Resistant Bacteria: From Neamine Derivatives to Smaller Neosamine Analogues.
AID1884061Antibacterial activity against Staphylococcus aureus LMG 10147 incubated for 20 hrs by CLSI based broth microdilution method2022Journal of natural products, 06-24, Volume: 85, Issue:6
Chemically Tuning Resveratrol for the Effective Killing of Gram-Positive Pathogens.
AID1318918Antibacterial activity against multidrug/extremely drug-resistant/colistin-susceptible Pseudomonas aeruginosa isolate 1000362016Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
Hybrid Antibiotic Overcomes Resistance in P. aeruginosa by Enhancing Outer Membrane Penetration and Reducing Efflux.
AID1867041Antimicrobial activity against Cryptococcus neoformans H99 assessed as reduction in bacterial growth and measured for 48 hrs by resazurin dye based broth microdilution method
AID1884068Antibacterial activity against Clostridium tetani CECT 4629 incubated for 24 hrs by CLSI based broth microdilution method2022Journal of natural products, 06-24, Volume: 85, Issue:6
Chemically Tuning Resveratrol for the Effective Killing of Gram-Positive Pathogens.
AID1609309Bactericidal activity against Escherichia coli BW251132019European journal of medicinal chemistry, Nov-15, Volume: 182Phenylthiazoles with nitrogenous side chain: An approach to overcome molecular obesity.
AID1430433Antibacterial activity against Staphylococcus aureus ATCC 25923 after overnight incubation by photometric method2017Bioorganic & medicinal chemistry letters, 03-01, Volume: 27, Issue:5
Synthesis and antimicrobial evaluation of cationic low molecular weight amphipathic 1,2,3-triazoles.
AID1516028Antibacterial activity against Pseudomonas aeruginosa 25349 clinical isolate incubated for 18 to 24 hrs by broth microdilution method2019Journal of medicinal chemistry, 08-08, Volume: 62, Issue:15
Design of Trp-Rich Dodecapeptides with Broad-Spectrum Antimicrobial Potency and Membrane-Disruptive Mechanism.
AID1539473Antibacterial activity against Salmonella enteritidis ATCC 14028 clinical isolates after 18 to 20 hrs in aerobic condition by CLSI-based broth microdilution assay
AID1282499Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 after 18 hrs by 2 fold serial dilution method2016Journal of medicinal chemistry, Feb-11, Volume: 59, Issue:3
Activity and Predicted Nephrotoxicity of Synthetic Antibiotics Based on Polymyxin B.
AID1524122Bactericidal activity against Escherichia coli UB1005 incubated for 4 hrs followed by culture spread on agar plates and cultured overnight2019Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5
Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria.
AID1539461Antibacterial activity against Acinetobacter baumannii ATCC BAA 1747 after 18 to 20 hrs in aerobic condition by CLSI-based broth microdilution assay
AID1369437Bactericidal activity against Salmonella typhimurium ATCC 140282018Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides.
AID1870140Antibacterial activity against wild type Staphylococcus aureus 4557/A assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay2022Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14
LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials.
AID1567133Antimicrobial activity against CA-methicillin-resistant Staphylococcus aureus W45 ST59 incubated for 20 hrs by microdilution method2019European journal of medicinal chemistry, Sep-15, Volume: 178Design, synthesis and biological evaluation of antimicrobial diarylimine and -amine compounds targeting the interaction between the bacterial NusB and NusE proteins.
AID1545125Antibacterial activity against Streptococcus mutans by CLSI protocol based method2019Journal of natural products, 08-23, Volume: 82, Issue:8
Antibacterial and Inhibitory Activities against Nitric Oxide Production of Coumaronochromones and Prenylated Isoflavones from
AID1324848Antimicrobial activity against Pseudomonas aeruginosa ATCC 27853 by CLSI M07-A9 method2016Journal of natural products, 07-22, Volume: 79, Issue:7
Polybrominated Diphenyl Ethers: Structure Determination and Trends in Antibacterial Activity.
AID1545132Antibacterial activity against Shigella flexneri by CLSI protocol based method2019Journal of natural products, 08-23, Volume: 82, Issue:8
Antibacterial and Inhibitory Activities against Nitric Oxide Production of Coumaronochromones and Prenylated Isoflavones from
AID1318925Antibacterial activity against pandrug-resistant Pseudomonas aeruginosa isolate 1012432016Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
Hybrid Antibiotic Overcomes Resistance in P. aeruginosa by Enhancing Outer Membrane Penetration and Reducing Efflux.
AID1809825Antimicrobial activity against Staphylococcus aureus ATCC 25923 assessed as inhibition of bacterial growth by broth dilution method2021Journal of medicinal chemistry, 10-28, Volume: 64, Issue:20
Tandem Repeat of a Short Human Chemerin-Derived Peptide and Its Nontoxic d-Lysine-Containing Enantiomer Display Broad-Spectrum Antimicrobial and Antitubercular Activities.
AID1585531Antibacterial activity against Proteus vulgaris ATCC 29213 after 24 hrs by broth dilution method2019European journal of medicinal chemistry, Jan-15, Volume: 162Benzofuran derivatives and their anti-tubercular, anti-bacterial activities.
AID1730946Antibacterial activity against Escherichia coli MTCC 443 assessed as bacterial growth inhibition2021Bioorganic & medicinal chemistry letters, 03-15, Volume: 36Structure based design, synthesis, and biological evaluation of imidazole derivatives targeting dihydropteroate synthase enzyme.
AID1713874Antibacterial activity against Proteus vulgaris ATCC 6380 assessed as bacterial growth inhibition by CLSI protocol based serial microdilution method2016Bioorganic & medicinal chemistry, 11-15, Volume: 24, Issue:22
Biological evaluation of tetracationic compounds based on two 1,4-diazabicyclo[2.2.2]octane moieties connected by different linkers.
AID1676981Antimicrobial activity against Escherichia coli JW55031 harboring TolC mutant assessed as reduction in microbial growth after 48 hrs by CLSI based broth microdilution method
AID1866150Antibacterial activity against Pseudomonas aeruginosa PA 14 assessed as inhibition of bacterial growth incubated for overnight by serial dilution method
AID1605815Resistance index, ratio of MIC for Acinetobacter baumannii ATCC 19606 measured after 4 serial passages by broth microdilution method to MIC for Acinetobacter baumannii ATCC 19606 incubated for 24 hrs by broth microdilution method2020Journal of medicinal chemistry, 04-09, Volume: 63, Issue:7
Rational Substitution of ε-Lysine for α-Lysine Enhances the Cell and Membrane Selectivity of Pore-Forming Melittin.
AID1516022Antibacterial activity against Escherichia coli UB1005 incubated for 18 to 24 hrs by broth microdilution method2019Journal of medicinal chemistry, 08-08, Volume: 62, Issue:15
Design of Trp-Rich Dodecapeptides with Broad-Spectrum Antimicrobial Potency and Membrane-Disruptive Mechanism.
AID1524033Antimicrobial activity against Escherichia coli UB1005 after 24 hrs by NCCLS-protocol based assay2019Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5
Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria.
AID1878029Antibacterial activity against Escherichia coli K12 harbouring elongation factor P deltayjeK variant assessed as reduction in bacterial growth incubated for 240 mins by turbidity based analysis2022Bioorganic & medicinal chemistry letters, 03-01, Volume: 59De-novo designed β-lysine derivatives can both augment and diminish the proliferation rates of E. coli through the action of Elongation Factor P.
AID1540931Effect on growth of Escherichia coli ATCC 25922 assessed as bacterial growth inhibition measured after 16 to 18 hrs by CLSI method
AID1591938Antibacterial activity against Escherichia coli by CLSI guideline based broth microdilution method2019Journal of natural products, 08-23, Volume: 82, Issue:8
Mallopenins A-E, Antibacterial Phenolic Derivatives from the Fruits of
AID1567114Antimicrobial activity against Staphylococcus aureus ATCC BAA43 incubated for 20 hrs by microdilution method2019European journal of medicinal chemistry, Sep-15, Volume: 178Design, synthesis and biological evaluation of antimicrobial diarylimine and -amine compounds targeting the interaction between the bacterial NusB and NusE proteins.
AID1497867Antibacterial activity against Proteus vulgaris PTCC 11822018Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12
Design, synthesis and biological evaluation of benzofuran appended benzothiazepine derivatives as inhibitors of butyrylcholinesterase and antimicrobial agents.
AID1282505Antibacterial activity against methicillin susceptible Staphylococcus aureus ATCC 25923 after 18 hrs by 2 fold serial dilution method2016Journal of medicinal chemistry, Feb-11, Volume: 59, Issue:3
Activity and Predicted Nephrotoxicity of Synthetic Antibiotics Based on Polymyxin B.
AID1713887Antibacterial activity against methicillin-resistant Staphylococcus aureus CEMTC 1850 assessed as concentration required to inhibit visible growth by CLSI protocol based serial microdilution method2016Bioorganic & medicinal chemistry, 11-15, Volume: 24, Issue:22
Biological evaluation of tetracationic compounds based on two 1,4-diazabicyclo[2.2.2]octane moieties connected by different linkers.
AID1369470Antibacterial activity against Escherichia coli ATCC 25922 after 18 hrs in presence of NaCl by broth dilution method2018Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides.
AID1713863Antibacterial activity against Enterococcus faecalis ATCC 51299 assessed as concentration required to inhibit visible growth by CLSI protocol based serial microdilution method2016Bioorganic & medicinal chemistry, 11-15, Volume: 24, Issue:22
Biological evaluation of tetracationic compounds based on two 1,4-diazabicyclo[2.2.2]octane moieties connected by different linkers.
AID1878475Antibacterial activity against Methicillin resistant Staphylococcus aureus ATCC 33591 assessed as inhibition of bacterial growth incubated for 90 mins by serial dilution assay2022European journal of medicinal chemistry, Mar-05, Volume: 231Systematic comparison of activity and mechanism of antimicrobial peptides against nosocomial pathogens.
AID1870145Antibacterial activity against wild type Staphylococcus aureus 4880/C assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay2022Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14
LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials.
AID1884065Antibacterial activity against Clostridium difficile CECT531 incubated for 24 hrs by CLSI based broth microdilution method2022Journal of natural products, 06-24, Volume: 85, Issue:6
Chemically Tuning Resveratrol for the Effective Killing of Gram-Positive Pathogens.
AID1265200Bactericidal activity against Klebsiella pneumoniae ATCC 43816 after 24 hrs2015Bioorganic & medicinal chemistry letters, Dec-15, Volume: 25, Issue:24
Synthesis, biological activity evaluation and molecular docking studies of novel coumarin substituted thiazolyl-3-aryl-pyrazole-4-carbaldehydes.
AID1282504Antibacterial activity against clinical isolate carbapenem and polymyxin resistant Klebsiella pneumoniae 138-16357-20362 after 18 hrs by 2 fold serial dilution method2016Journal of medicinal chemistry, Feb-11, Volume: 59, Issue:3
Activity and Predicted Nephrotoxicity of Synthetic Antibiotics Based on Polymyxin B.
AID1524136Bactericidal activity against Klebsiella pneumoniae incubated for 4 hrs followed by culture spread on agar plates and cultured overnight2019Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5
Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria.
AID1416411Antibacterial activity against Staphylococcus aureus incubated for 24 hrs by microdilution method2017MedChemComm, Aug-01, Volume: 8, Issue:8
Synthesis and molecular docking studies of xanthone attached amino acids as potential antimicrobial and anti-inflammatory agents.
AID1430432Antibacterial activity against Enterococcus faecalis ATCC 29212 after overnight incubation by photometric method2017Bioorganic & medicinal chemistry letters, 03-01, Volume: 27, Issue:5
Synthesis and antimicrobial evaluation of cationic low molecular weight amphipathic 1,2,3-triazoles.
AID1870152Antibacterial activity against wild type Staphylococcus aureus 4738/B assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay2022Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14
LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials.
AID1713888Antibacterial activity against methicillin-resistant Staphylococcus aureus CEMTC 1850 assessed as bacterial growth inhibition by CLSI protocol based serial microdilution method2016Bioorganic & medicinal chemistry, 11-15, Volume: 24, Issue:22
Biological evaluation of tetracationic compounds based on two 1,4-diazabicyclo[2.2.2]octane moieties connected by different linkers.
AID1713871Antibacterial activity against Citrobacter freundii ATCC 8090 assessed as concentration required to inhibit visible growth by CLSI protocol based serial microdilution method2016Bioorganic & medicinal chemistry, 11-15, Volume: 24, Issue:22
Biological evaluation of tetracationic compounds based on two 1,4-diazabicyclo[2.2.2]octane moieties connected by different linkers.
AID1282521Cytotoxicity against HK2 cells assessed as LDH release by Western blot analysis2016Journal of medicinal chemistry, Feb-11, Volume: 59, Issue:3
Activity and Predicted Nephrotoxicity of Synthetic Antibiotics Based on Polymyxin B.
AID1653074Antibacterial activity against Pseudomonas aeruginosa assessed as zone of inhibition at 100 ug/ml2019European journal of medicinal chemistry, Feb-15, Volume: 164Isatin derivatives and their anti-bacterial activities.
AID1524133Bactericidal activity against Salmonella typhimurium C7731 incubated for 4 hrs followed by culture spread on agar plates and cultured overnight2019Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5
Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria.
AID1870126Antibacterial activity against antibiotic resistant Staphylococcus aureus 4504/A assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay2022Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14
LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials.
AID1422364Antibacterial activity against Staphylococcus aureus ATCC 25923 by microdilution assay2018European journal of medicinal chemistry, Sep-05, Volume: 157Broad-spectrum antibacterial amphiphilic aminoglycosides: A new focus on the structure of the lipophilic groups extends the series of active dialkyl neamines.
AID1608430Antibacterial activity against Klebsiella pneumoniae2019European journal of medicinal chemistry, Oct-15, Volume: 180Role of sulphur-heterocycles in medicinal chemistry: An update.
AID1430402Antibacterial activity against Escherichia coli ATCC 35421 after 24 to 48 hrs by macro-broth dilution method2017Bioorganic & medicinal chemistry letters, 03-01, Volume: 27, Issue:5
Methylsulfonyl benzothiazoles (MSBT) derivatives: Search for new potential antimicrobial and anticancer agents.
AID1497863Antibacterial activity against Escherichia coli ATCC 105362018Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12
Design, synthesis and biological evaluation of benzofuran appended benzothiazepine derivatives as inhibitors of butyrylcholinesterase and antimicrobial agents.
AID1616733Antiproliferative activity against human U251 cells assessed as reduction in cell viability after 72 hrs by SRB assay
AID1442090Antibacterial activity against ciprofloxacin-resistant Pseudomonas aeruginosa 11411 after 18 hrs by broth microdilution method2017Journal of medicinal chemistry, 03-23, Volume: 60, Issue:6
Novel Design of Heptad Amphiphiles To Enhance Cell Selectivity, Salt Resistance, Antibiofilm Properties and Their Membrane-Disruptive Mechanism.
AID1318937Antibacterial activity against multidrug-resistant/tobramycin-susceptible Pseudomonas aeruginosa isolate 853222016Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
Hybrid Antibiotic Overcomes Resistance in P. aeruginosa by Enhancing Outer Membrane Penetration and Reducing Efflux.
AID1539476Antibacterial activity against Pseudomonas aeruginosa ATCC 9027 clinical isolates after 18 to 20 hrs in aerobic condition by CLSI-based broth microdilution assay
AID1524125Bactericidal activity against Escherichia coli K99 incubated for 4 hrs followed by culture spread on agar plates and cultured overnight2019Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5
Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria.
AID1299613Toxicity in Caenorhabditis elegans N2 assessed as effect on viable eggs production treated at high concentration2016Journal of medicinal chemistry, Apr-14, Volume: 59, Issue:7
Antibacterial Diamines Targeting Bacterial Membranes.
AID1609307Antibacterial activity against Pseudomonas aeruginosa ATCC 154422019European journal of medicinal chemistry, Nov-15, Volume: 182Phenylthiazoles with nitrogenous side chain: An approach to overcome molecular obesity.
AID1689748Antibacterial activity against gentamicin-colistin-resistant Escherichia coli 288328 assessed as inhibition of visible growth after 24 hrs by broth microdilution method2020European journal of medicinal chemistry, Mar-01, Volume: 189Simple amphiphilic α-hydrazido acids: Rational design, synthesis, and in vitro bioactivity profile of a novel class of potential antimicrobial compounds.
AID1884067Antibacterial activity against Clostridium perfringens CECT376 incubated for 24 hrs by CLSI based broth microdilution method2022Journal of natural products, 06-24, Volume: 85, Issue:6
Chemically Tuning Resveratrol for the Effective Killing of Gram-Positive Pathogens.
AID1627297Antibacterial activity against Escherichia coli ATCC 25922 by broth microdilution method2016Bioorganic & medicinal chemistry letters, 08-15, Volume: 26, Issue:16
New antibacterial agents: Hybrid bioisoster derivatives as potential E. coli FabH inhibitors.
AID1422368Antibacterial activity against Pseudomonas aeruginosa FO3 harboring AAC6'-2A by microdilution assay2018European journal of medicinal chemistry, Sep-05, Volume: 157Broad-spectrum antibacterial amphiphilic aminoglycosides: A new focus on the structure of the lipophilic groups extends the series of active dialkyl neamines.
AID1609304Antibacterial activity against Escherichia coli ATCC 259222019European journal of medicinal chemistry, Nov-15, Volume: 182Phenylthiazoles with nitrogenous side chain: An approach to overcome molecular obesity.
AID1627405Cytotoxicity against human WS1 cells by resazurin reduction assay2016Bioorganic & medicinal chemistry, 09-15, Volume: 24, Issue:18
Structure elucidation of anti-methicillin resistant Staphylococcus aureus (MRSA) flavonoids from balsam poplar buds.
AID1567129Antimicrobial activity against Staphylococcus aureus ST239 incubated for 20 hrs by microdilution method2019European journal of medicinal chemistry, Sep-15, Volume: 178Design, synthesis and biological evaluation of antimicrobial diarylimine and -amine compounds targeting the interaction between the bacterial NusB and NusE proteins.
AID1497860Antibacterial activity against Shigella dysenteriae PTCC 1188 assessed as diameter of inhibition zone at 200 ug per disc after 24 hrs by agar disc diffusion method2018Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12
Design, synthesis and biological evaluation of benzofuran appended benzothiazepine derivatives as inhibitors of butyrylcholinesterase and antimicrobial agents.
AID1809839Antibacterial activity against Pseudomonas aeruginosa BAA 427 assessed as resistance development by measuring fold change in MIC after 30 passages with serially diluted peptides2021Journal of medicinal chemistry, 10-28, Volume: 64, Issue:20
Tandem Repeat of a Short Human Chemerin-Derived Peptide and Its Nontoxic d-Lysine-Containing Enantiomer Display Broad-Spectrum Antimicrobial and Antitubercular Activities.
AID1393149Antimicrobial activity against Haemophilus influenzae L3296 by broth microdilution method2017Journal of natural products, 04-28, Volume: 80, Issue:4
Antibacterial Paramagnetic Quinones from Actinoallomurus.
AID1393144Antimicrobial activity against Mycobacterium smegmatis str. MC2 155 by broth microdilution method2017Journal of natural products, 04-28, Volume: 80, Issue:4
Antibacterial Paramagnetic Quinones from Actinoallomurus.
AID1878477Bactericidal activity against Escherichia coli ATCC 25922 incubated for 90 mins by serial dilution assay2022European journal of medicinal chemistry, Mar-05, Volume: 231Systematic comparison of activity and mechanism of antimicrobial peptides against nosocomial pathogens.
AID1870150Antibacterial activity against wild type Staphylococcus aureus 4740/B assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay2022Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14
LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials.
AID1471212Antibacterial activity against Klebsiella pneumoniae ATCC 27736 by spectrophotometric method2017Bioorganic & medicinal chemistry letters, 07-01, Volume: 27, Issue:13
Diversity-oriented sustainable synthesis of antimicrobial spiropyrrolidine/thiapyrrolizidine oxindole derivatives: New ligands for a metallo-β-lactamase from Klebsiella pneumonia.
AID1545128Antibacterial activity against Staphylococcus aureus by CLSI protocol based method2019Journal of natural products, 08-23, Volume: 82, Issue:8
Antibacterial and Inhibitory Activities against Nitric Oxide Production of Coumaronochromones and Prenylated Isoflavones from
AID1391501Antibacterial activity against Pseudomonas aeruginosa after 24 hrs by UV-vis spectrophotometric method
AID1516027Antibacterial activity against Acinetobacter baumannii AB1902 clinical isolate incubated for 18 to 24 hrs by broth microdilution method2019Journal of medicinal chemistry, 08-08, Volume: 62, Issue:15
Design of Trp-Rich Dodecapeptides with Broad-Spectrum Antimicrobial Potency and Membrane-Disruptive Mechanism.
AID1713862Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 25923 assessed as bacterial growth inhibition by CLSI protocol based serial microdilution method2016Bioorganic & medicinal chemistry, 11-15, Volume: 24, Issue:22
Biological evaluation of tetracationic compounds based on two 1,4-diazabicyclo[2.2.2]octane moieties connected by different linkers.
AID1322257Antibacterial activity against AAC6'-IB expressing Escherichia coli PAZ505H8101 by microdilution method2016Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20
New Broad-Spectrum Antibacterial Amphiphilic Aminoglycosides Active against Resistant Bacteria: From Neamine Derivatives to Smaller Neosamine Analogues.
AID1299635Toxicity in juvenile L1 stage of Caenorhabditis elegans N2 assessed as nematode death at 64 ug/ml incubated for 96 hrs measured every 12 hrs2016Journal of medicinal chemistry, Apr-14, Volume: 59, Issue:7
Antibacterial Diamines Targeting Bacterial Membranes.
AID1379751Antimicrobial activity against Bacillus cereus incubated for 24 hrs by serial dilution method2017European journal of medicinal chemistry, Nov-10, Volume: 140Synthesis, antimicrobial, antiquorum-sensing, antitumor and cytotoxic activities of new series of cyclopenta(hepta)[b]thiophene and fused cyclohepta[b]thiophene analogs.
AID1356821Antimicrobial activity against Klebsiella pneumoniae ATCC 43816 by broth microdilution method2018Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
Total Synthesis and Structure-Activity Relationships Study of Odilorhabdins, a New Class of Peptides Showing Potent Antibacterial Activity.
AID1265203Bactericidal activity against Bacillus subtilis ATCC 6633 after 24 hrs2015Bioorganic & medicinal chemistry letters, Dec-15, Volume: 25, Issue:24
Synthesis, biological activity evaluation and molecular docking studies of novel coumarin substituted thiazolyl-3-aryl-pyrazole-4-carbaldehydes.
AID1497864Antibacterial activity against Pseudomonas aeruginosa ATCC 278532018Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12
Design, synthesis and biological evaluation of benzofuran appended benzothiazepine derivatives as inhibitors of butyrylcholinesterase and antimicrobial agents.
AID1675237Antimicrobial activity against Staphylococcus aureus DSM346 by serial dilution method2020Journal of natural products, 08-28, Volume: 83, Issue:8
Heimiomycins A-C and Calamenens from the African Basidiomycete
AID1442094Antibacterial activity against Pseudomonas aeruginosa 25349 clinical isolate after 18 hrs by broth microdilution method2017Journal of medicinal chemistry, 03-23, Volume: 60, Issue:6
Novel Design of Heptad Amphiphiles To Enhance Cell Selectivity, Salt Resistance, Antibiofilm Properties and Their Membrane-Disruptive Mechanism.
AID1356824Antimicrobial activity against Klebsiella pneumoniae ATCC BAA-1905 by broth microdilution method2018Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
Total Synthesis and Structure-Activity Relationships Study of Odilorhabdins, a New Class of Peptides Showing Potent Antibacterial Activity.
AID1416385Antibacterial activity against Staphylococcus aureus at 75 ug/ml incubated for 24 hrs by agar well diffusion method2017MedChemComm, Aug-01, Volume: 8, Issue:8
Synthesis and molecular docking studies of xanthone attached amino acids as potential antimicrobial and anti-inflammatory agents.
AID1609310Bactericidal activity against TolC-deficient Escherichia coli JW550312019European journal of medicinal chemistry, Nov-15, Volume: 182Phenylthiazoles with nitrogenous side chain: An approach to overcome molecular obesity.
AID1322255Antibacterial activity against APH3'-VIA expressing Acinetobacter lwoffii AI.88-483 by microdilution method2016Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20
New Broad-Spectrum Antibacterial Amphiphilic Aminoglycosides Active against Resistant Bacteria: From Neamine Derivatives to Smaller Neosamine Analogues.
AID1567136Antimicrobial activity against Staphylococcus aureus ST22 11B086169 incubated for 20 hrs by microdilution method2019European journal of medicinal chemistry, Sep-15, Volume: 178Design, synthesis and biological evaluation of antimicrobial diarylimine and -amine compounds targeting the interaction between the bacterial NusB and NusE proteins.
AID1422376Antibacterial activity against Klebsiella pneumoniae 700603 by microdilution assay2018European journal of medicinal chemistry, Sep-05, Volume: 157Broad-spectrum antibacterial amphiphilic aminoglycosides: A new focus on the structure of the lipophilic groups extends the series of active dialkyl neamines.
AID1282497Antibacterial activity against Klebsiella pneumoniae ATCC BAA-2146 expressing NDM-1 after 18 hrs by 2 fold serial dilution method2016Journal of medicinal chemistry, Feb-11, Volume: 59, Issue:3
Activity and Predicted Nephrotoxicity of Synthetic Antibiotics Based on Polymyxin B.
AID1462763Antimicrobial activity against Escherichia coli ATCC 25922 assessed as growth inhibition incubated overnight at 37degC by visual and photometry based method2017Bioorganic & medicinal chemistry, 10-15, Volume: 25, Issue:20
Methyl propiolate and 3-butynone: Starting points for synthesis of amphiphilic 1,2,3-triazole peptidomimetics for antimicrobial evaluation.
AID1444330Antibacterial activity against Klebsiella pneumoniae HK11750/08 after 24 hrs by broth microdilution method2017European journal of medicinal chemistry, Apr-21, Volume: 130Structure-activity relationship studies on 3,5-dinitrophenyl tetrazoles as antitubercular agents.
AID1627394Antibacterial activity against Staphylococcus aureus ATCC 25923 incubated for 7 to 14 days by microdilution resazurin assay2016Bioorganic & medicinal chemistry, 09-15, Volume: 24, Issue:18
Structure elucidation of anti-methicillin resistant Staphylococcus aureus (MRSA) flavonoids from balsam poplar buds.
AID1713865Antibacterial activity against Pseudomonas aeruginosa ATCC 9027 assessed as concentration required to inhibit visible growth by CLSI protocol based serial microdilution method2016Bioorganic & medicinal chemistry, 11-15, Volume: 24, Issue:22
Biological evaluation of tetracationic compounds based on two 1,4-diazabicyclo[2.2.2]octane moieties connected by different linkers.
AID1545124Antibacterial activity against Micrococcus luteus by CLSI protocol based method2019Journal of natural products, 08-23, Volume: 82, Issue:8
Antibacterial and Inhibitory Activities against Nitric Oxide Production of Coumaronochromones and Prenylated Isoflavones from
AID1687307Antimicrobial activity against Escherichia coli JW55031 TolC mutant assessed as reduction in microbial growth incubated for 18 to 20 hrs by broth microdilution method2020European journal of medicinal chemistry, Jan-15, Volume: 186Development of benzimidazole-based derivatives as antimicrobial agents and their synergistic effect with colistin against gram-negative bacteria.
AID1772169Antibacterial activity against Staphylococcus aureus ATCC 25923 assessed as reduction in bacterial growth incubated for 24 hrs by microdilution method2021Journal of natural products, 11-26, Volume: 84, Issue:11
Effect of the Chromone Core Substitution of Dirchromone on the Resultant Biological Activities.
AID1360038Antimicrobial activity against Bacillus cereus after 18 to 20 hrs by micro broth dilution method2018European journal of medicinal chemistry, Jun-25, Volume: 154Free radical rearrangement synthesis and microbiological evaluation of novel 2-sulfoether-4-quinolone scaffolds as potential antibacterial agents.
AID1567123Antimicrobial activity against Enterobacter cloacae ATCC 13047 incubated for 20 hrs by microdilution method2019European journal of medicinal chemistry, Sep-15, Volume: 178Design, synthesis and biological evaluation of antimicrobial diarylimine and -amine compounds targeting the interaction between the bacterial NusB and NusE proteins.
AID1713880Antibacterial activity against methicillin-resistant Staphylococcus aureus CEMTC 707 assessed as bacterial growth inhibition by CLSI protocol based serial microdilution method2016Bioorganic & medicinal chemistry, 11-15, Volume: 24, Issue:22
Biological evaluation of tetracationic compounds based on two 1,4-diazabicyclo[2.2.2]octane moieties connected by different linkers.
AID1585528Antibacterial activity against Bacillus subtilis ATCC 6633 after 24 hrs by broth dilution method2019European journal of medicinal chemistry, Jan-15, Volume: 162Benzofuran derivatives and their anti-tubercular, anti-bacterial activities.
AID1884064Antibacterial activity against Clostridium botulinum CECT551 incubated for 24 hrs by CLSI based broth microdilution method2022Journal of natural products, 06-24, Volume: 85, Issue:6
Chemically Tuning Resveratrol for the Effective Killing of Gram-Positive Pathogens.
AID1471209Antibacterial activity against Escherichia coli ATCC 9637 by spectrophotometric method2017Bioorganic & medicinal chemistry letters, 07-01, Volume: 27, Issue:13
Diversity-oriented sustainable synthesis of antimicrobial spiropyrrolidine/thiapyrrolizidine oxindole derivatives: New ligands for a metallo-β-lactamase from Klebsiella pneumonia.
AID1539470Antibacterial activity against Klebsiella pneumoniae BAA-1144 clinical isolates after 18 to 20 hrs in aerobic condition by CLSI-based broth microdilution assay
AID1422378Cytotoxicity against mouse J774 cells assessed as cell viability at 30 uM after 24 hrs by MTT assay relative to control2018European journal of medicinal chemistry, Sep-05, Volume: 157Broad-spectrum antibacterial amphiphilic aminoglycosides: A new focus on the structure of the lipophilic groups extends the series of active dialkyl neamines.
AID1422373Antibacterial activity against Escherichia coli ATCC 25922 by microdilution assay2018European journal of medicinal chemistry, Sep-05, Volume: 157Broad-spectrum antibacterial amphiphilic aminoglycosides: A new focus on the structure of the lipophilic groups extends the series of active dialkyl neamines.
AID1422371Antibacterial activity against Acinetobacter lwoffii ATCC 17925 by microdilution assay2018European journal of medicinal chemistry, Sep-05, Volume: 157Broad-spectrum antibacterial amphiphilic aminoglycosides: A new focus on the structure of the lipophilic groups extends the series of active dialkyl neamines.
AID1524132Bactericidal activity against Salmonella typhimurium ATCC 14028 incubated for 4 hrs followed by culture spread on agar plates and cultured overnight2019Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5
Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria.
AID1482267Antibacterial activity against Escherichia coli MG1655 measured every 15 mins for 12 hrs2017Journal of medicinal chemistry, 05-11, Volume: 60, Issue:9
Prediction of Antibiotic Interactions Using Descriptors Derived from Molecular Structure.
AID1272237Antibacterial activity against Staphylococcus aureus by broth micro-dilution method2016Bioorganic & medicinal chemistry letters, Feb-01, Volume: 26, Issue:3
Efficiently functionalized oxacalix[4]arenes: Synthesis, characterization and exploration of their biological profile as novel HDAC inhibitors.
AID1462762Antimicrobial activity against Streptococcus agalactiae ATCC 12386 assessed as growth inhibition incubated overnight at 37degC by visual and photometry based method2017Bioorganic & medicinal chemistry, 10-15, Volume: 25, Issue:20
Methyl propiolate and 3-butynone: Starting points for synthesis of amphiphilic 1,2,3-triazole peptidomimetics for antimicrobial evaluation.
AID1677469Antibacterial activity against vancomycin-resistant Enterococcus faecalis2020Bioorganic & medicinal chemistry letters, 11-01, Volume: 30, Issue:21
New antibacterial cadiolide analogues active against antibiotic-resistant strains.
AID1497862Antibacterial activity against Salmonella paratyphi A serotype ATCC 57022018Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12
Design, synthesis and biological evaluation of benzofuran appended benzothiazepine derivatives as inhibitors of butyrylcholinesterase and antimicrobial agents.
AID1322252Antibacterial activity against MexXY expressing Pseudomonas aeruginosa PA22 by microdilution method2016Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20
New Broad-Spectrum Antibacterial Amphiphilic Aminoglycosides Active against Resistant Bacteria: From Neamine Derivatives to Smaller Neosamine Analogues.
AID1369442Bactericidal activity against Staphylococcus aureus ATCC 259232018Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides.
AID1422369Antibacterial activity against Pseudomonas aeruginosa PA22 harboring surexp MexXY by microdilution assay2018European journal of medicinal chemistry, Sep-05, Volume: 157Broad-spectrum antibacterial amphiphilic aminoglycosides: A new focus on the structure of the lipophilic groups extends the series of active dialkyl neamines.
AID1322261Cytotoxicity against mouse J774 cells assessed as cell viability at 30 uM after 24 hrs by MTT assay relative to control2016Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20
New Broad-Spectrum Antibacterial Amphiphilic Aminoglycosides Active against Resistant Bacteria: From Neamine Derivatives to Smaller Neosamine Analogues.
AID1462771Inhibition of biofilm formation of Staphylococcus epidermidis incubated overnight at 37degC by crystal violet based assay2017Bioorganic & medicinal chemistry, 10-15, Volume: 25, Issue:20
Methyl propiolate and 3-butynone: Starting points for synthesis of amphiphilic 1,2,3-triazole peptidomimetics for antimicrobial evaluation.
AID1870156Antibacterial activity against wild type Staphylococcus aureus 4515/A assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay2022Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14
LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials.
AID1322254Antibacterial activity against Acinetobacter lwoffii ATCC 17925 by microdilution method2016Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20
New Broad-Spectrum Antibacterial Amphiphilic Aminoglycosides Active against Resistant Bacteria: From Neamine Derivatives to Smaller Neosamine Analogues.
AID1575411Antibacterial activity against Vancomycin A-inducible resistant Enterococcus faecium isolate 569 after 16 hrs by agar diffusion method2019Journal of natural products, 01-25, Volume: 82, Issue:1
Antibacterial Aromatic Polyketides Incorporating the Unusual Amino Acid Enduracididine.
AID1516025Antibacterial activity against Escherichia coli 20411 clinical isolate incubated for 18 to 24 hrs by broth microdilution method2019Journal of medicinal chemistry, 08-08, Volume: 62, Issue:15
Design of Trp-Rich Dodecapeptides with Broad-Spectrum Antimicrobial Potency and Membrane-Disruptive Mechanism.
AID1271952Antibacterial activity against Pseudomonas aeruginosa assessed as growth inhibition at 1 mg/ml by drug sensitive assay2016Bioorganic & medicinal chemistry letters, Jan-15, Volume: 26, Issue:2
Novel skeleton compound Allomyrinanoid A and two purine alkaloids from the adult of Allomyrina dichotoma L.
AID1493076Antibacterial activity against vancomycin-resistant Enterococcus faecium 7 by dilution susceptibility test2017Journal of natural products, 11-22, Volume: 80, Issue:11
Antibacterial 3,6-Disubstituted 4-Hydroxy-5,6-dihydro-2H-pyran-2-ones from Serratia plymuthica MF371-2.
AID1524052Ratio of MBC against Pseudomonas aeruginosa ATCC 27853 after 26 to 60 passages to MBC against Pseudomonas aeruginosa ATCC 278532019Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5
Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria.
AID1545129Antibacterial activity against Salmonella typhimurium by CLSI protocol based method2019Journal of natural products, 08-23, Volume: 82, Issue:8
Antibacterial and Inhibitory Activities against Nitric Oxide Production of Coumaronochromones and Prenylated Isoflavones from
AID1540930Effect on growth of Bifidobacterium bifidum 212A ATCC 11863 measured after 48 hrs in anerobic conditions by CLSI method
AID1689206Antibacterial activity against Escherichia coli JW55031 harboring tolC mutation assessed as reduction in bacterial growth by CLSI based broth microdilution method2020European journal of medicinal chemistry, Mar-01, Volume: 189Oxadiazolylthiazoles as novel and selective antifungal agents.
AID1416386Antibacterial activity against Staphylococcus aureus at 100 ug/ml incubated for 24 hrs by agar well diffusion method2017MedChemComm, Aug-01, Volume: 8, Issue:8
Synthesis and molecular docking studies of xanthone attached amino acids as potential antimicrobial and anti-inflammatory agents.
AID1627400Antibacterial activity against methicillin resistant Staphylococcus aureus clinical isolate 6 incubated for 7 to 14 days by microdilution resazurin assay2016Bioorganic & medicinal chemistry, 09-15, Volume: 24, Issue:18
Structure elucidation of anti-methicillin resistant Staphylococcus aureus (MRSA) flavonoids from balsam poplar buds.
AID1416390Antibacterial activity against Bacillus subtilis at 100 ug/ml incubated for 24 hrs by agar well diffusion method2017MedChemComm, Aug-01, Volume: 8, Issue:8
Synthesis and molecular docking studies of xanthone attached amino acids as potential antimicrobial and anti-inflammatory agents.
AID1501224Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 measured after 18 hrs by dilution susceptibility test2017Journal of natural products, 09-22, Volume: 80, Issue:9
Thalassosamide, a Siderophore Discovered from the Marine-Derived Bacterium Thalassospira profundimaris.
AID1689767Antibacterial activity against Staphylococcus aureus ATCC 292132020European journal of medicinal chemistry, Mar-01, Volume: 189Simple amphiphilic α-hydrazido acids: Rational design, synthesis, and in vitro bioactivity profile of a novel class of potential antimicrobial compounds.
AID1627396Antibacterial activity against methicillin resistant Staphylococcus aureus clinical isolate 2 incubated for 7 to 14 days by microdilution resazurin assay2016Bioorganic & medicinal chemistry, 09-15, Volume: 24, Issue:18
Structure elucidation of anti-methicillin resistant Staphylococcus aureus (MRSA) flavonoids from balsam poplar buds.
AID1630581Antibacterial activity against multidrug resistant Enterococcus faecalis 5210 after 24 hrs by two fold serial dilution method2016Bioorganic & medicinal chemistry letters, 10-15, Volume: 26, Issue:20
Synthesis and antibacterial evaluation of hamacanthin B analogues.
AID1567130Antimicrobial activity against Staphylococcus aureus ATCC BAA44 incubated for 20 hrs by microdilution method2019European journal of medicinal chemistry, Sep-15, Volume: 178Design, synthesis and biological evaluation of antimicrobial diarylimine and -amine compounds targeting the interaction between the bacterial NusB and NusE proteins.
AID1625355Antibacterial activity against Escherichia coli DSM 1116 incubated for 24 hrs by disk diffusion method2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Antibacterial Azaphilones from an Endophytic Fungus, Colletotrichum sp. BS4.
AID1627398Antibacterial activity against methicillin resistant Staphylococcus aureus clinical isolate 4 incubated for 7 to 14 days by microdilution resazurin assay2016Bioorganic & medicinal chemistry, 09-15, Volume: 24, Issue:18
Structure elucidation of anti-methicillin resistant Staphylococcus aureus (MRSA) flavonoids from balsam poplar buds.
AID1322247Antibacterial activity against Staphylococcus aureus ATCC 25923 by microdilution method2016Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20
New Broad-Spectrum Antibacterial Amphiphilic Aminoglycosides Active against Resistant Bacteria: From Neamine Derivatives to Smaller Neosamine Analogues.
AID1271797Antibacterial activity against Escherichia coli 27 after 24 hrs by broth microdilution method2016Bioorganic & medicinal chemistry letters, Jan-15, Volume: 26, Issue:2
Synthesis, antibacterial and cytotoxic activities of new biflorin-based hydrazones and oximes.
AID1471210Antibacterial activity against Pseudomonas aeruginosa ATCC BAA-427 by spectrophotometric method2017Bioorganic & medicinal chemistry letters, 07-01, Volume: 27, Issue:13
Diversity-oriented sustainable synthesis of antimicrobial spiropyrrolidine/thiapyrrolizidine oxindole derivatives: New ligands for a metallo-β-lactamase from Klebsiella pneumonia.
AID1501243Antibacterial activity against Pseudomonas aeruginosa ATCC 13388 measured after overnight incubation2017Journal of natural products, 09-22, Volume: 80, Issue:9
Thermoactinoamide A, an Antibiotic Lipophilic Cyclopeptide from the Icelandic Thermophilic Bacterium Thermoactinomyces vulgaris.
AID1592959Antibacterial activity against multi-drug resistant Klebsiella pneumoniae NMI 2697/14 assessed as reduction in microbial growth incubated for 20 hrs2019European journal of medicinal chemistry, Apr-15, Volume: 168Microwave-assisted solid-phase synthesis of antisense acpP peptide nucleic acid-peptide conjugates active against colistin- and tigecycline-resistant E. coli and K. pneumoniae.
AID1539475Antibacterial activity against Shigella flexneri ATCC 9199 clinical isolates after 18 to 20 hrs in aerobic condition by CLSI-based broth microdilution assay
AID1524046Antimicrobial activity against Acinetobacter baumannii after 24 hrs by NCCLS-protocol based assay2019Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5
Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria.
AID1809602Antibacterial activity against Escherichia coli ATCC 25922 assessed as zone of inhibition at 15 mg/ml2021Bioorganic & medicinal chemistry letters, 11-15, Volume: 52Synthesis, anti-microbial, toxicity and molecular docking studies of N-nitroso-N-phenylhydroxylamine (cupferron) and its derivatives.
AID1809826Antimicrobial activity against methicilin- resistant Staphylococcus aureus ATCC 33591 assessed as inhibition of bacterial growth by broth dilution method2021Journal of medicinal chemistry, 10-28, Volume: 64, Issue:20
Tandem Repeat of a Short Human Chemerin-Derived Peptide and Its Nontoxic d-Lysine-Containing Enantiomer Display Broad-Spectrum Antimicrobial and Antitubercular Activities.
AID1422375Antibacterial activity against Escherichia coli L8058.1 harboring ANT2'-1A by microdilution assay2018European journal of medicinal chemistry, Sep-05, Volume: 157Broad-spectrum antibacterial amphiphilic aminoglycosides: A new focus on the structure of the lipophilic groups extends the series of active dialkyl neamines.
AID1322259Antibacterial activity against Klebsiella pneumoniae ATCC 700603 by microdilution method2016Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20
New Broad-Spectrum Antibacterial Amphiphilic Aminoglycosides Active against Resistant Bacteria: From Neamine Derivatives to Smaller Neosamine Analogues.
AID1524130Bactericidal activity against Pseudomonas aeruginosa CICC 21625 clinical isolates incubated for 4 hrs followed by culture spread on agar plates and cultured overnight2019Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5
Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria.
AID1809594Antibacterial activity against Bacillus subtilis ATCC 23857 assessed as zone of inhibition at 5 mg/ml2021Bioorganic & medicinal chemistry letters, 11-15, Volume: 52Synthesis, anti-microbial, toxicity and molecular docking studies of N-nitroso-N-phenylhydroxylamine (cupferron) and its derivatives.
AID1369486Antibacterial activity against Escherichia coli ATCC 25922 after 18 hrs in presence of 50% human heat-inactivated serum by broth dilution method2018Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides.
AID1609305Antibacterial activity against Klebsiella pneumoniae BAA-17062019European journal of medicinal chemistry, Nov-15, Volume: 182Phenylthiazoles with nitrogenous side chain: An approach to overcome molecular obesity.
AID1870158Antibacterial activity against wild type Staphylococcus aureus 4788/B assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay2022Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14
LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials.
AID1627401Antibacterial activity against methicillin resistant Staphylococcus aureus clinical isolate 7 incubated for 7 to 14 days by microdilution resazurin assay2016Bioorganic & medicinal chemistry, 09-15, Volume: 24, Issue:18
Structure elucidation of anti-methicillin resistant Staphylococcus aureus (MRSA) flavonoids from balsam poplar buds.
AID1524128Bactericidal activity against Pseudomonas aeruginosa CICC 21630 clinical isolates incubated for 4 hrs followed by culture spread on agar plates and cultured overnight2019Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5
Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria.
AID1321294Antimicrobial activity against Pseudomonas aeruginosa IFO 3448 measured after 24 hrs by microdilution method2016Bioorganic & medicinal chemistry letters, 10-01, Volume: 26, Issue:19
Synthesis, biological evaluation and molecular modeling study of some new methoxylated 2-benzylthio-quinazoline-4(3H)-ones as nonclassical antifolates.
AID1265202Bactericidal activity against methicillin-resistant Staphylococcus aureus NCTC 13616 after 24 hrs2015Bioorganic & medicinal chemistry letters, Dec-15, Volume: 25, Issue:24
Synthesis, biological activity evaluation and molecular docking studies of novel coumarin substituted thiazolyl-3-aryl-pyrazole-4-carbaldehydes.
AID1677472Antibacterial activity against Enterococcus faecalis NCTC126972020Bioorganic & medicinal chemistry letters, 11-01, Volume: 30, Issue:21
New antibacterial cadiolide analogues active against antibiotic-resistant strains.
AID1356834Antimicrobial activity against Escherichia coli ATCC BAA-2452 by broth microdilution method2018Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
Total Synthesis and Structure-Activity Relationships Study of Odilorhabdins, a New Class of Peptides Showing Potent Antibacterial Activity.
AID1575400Antibacterial activity against Staphylococcus aureus ATCC 6538P after 16 hrs by agar diffusion method2019Journal of natural products, 01-25, Volume: 82, Issue:1
Antibacterial Aromatic Polyketides Incorporating the Unusual Amino Acid Enduracididine.
AID1278313Antimicrobial activity against Pseudomonas aeruginosa PAO1 after 18 hrs by microdilution method in presence of 40 uM iron2016European journal of medicinal chemistry, Mar-03, Volume: 110Design, synthesis and biological evaluation of monobactams as antibacterial agents against gram-negative bacteria.
AID1524124Bactericidal activity against Escherichia coli K88 incubated for 4 hrs followed by culture spread on agar plates and cultured overnight2019Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5
Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria.
AID1627399Antibacterial activity against methicillin resistant Staphylococcus aureus clinical isolate 5 incubated for 7 to 14 days by microdilution resazurin assay2016Bioorganic & medicinal chemistry, 09-15, Volume: 24, Issue:18
Structure elucidation of anti-methicillin resistant Staphylococcus aureus (MRSA) flavonoids from balsam poplar buds.
AID1360044Antimicrobial activity against methicillin-resistant Staphylococcus aureus after 18 to 20 hrs by micro broth dilution method2018European journal of medicinal chemistry, Jun-25, Volume: 154Free radical rearrangement synthesis and microbiological evaluation of novel 2-sulfoether-4-quinolone scaffolds as potential antibacterial agents.
AID1356830Antimicrobial activity against Klebsiella pneumoniae ATCC BAA-2473 by broth microdilution method2018Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
Total Synthesis and Structure-Activity Relationships Study of Odilorhabdins, a New Class of Peptides Showing Potent Antibacterial Activity.
AID1321218Antimicrobial activity against Candida albicans IFO 0583 at 200 ug/disc measured after 48 hrs by agar disc-diffusion method2016Bioorganic & medicinal chemistry letters, 10-01, Volume: 26, Issue:19
Synthesis, biological evaluation and molecular modeling study of some new methoxylated 2-benzylthio-quinazoline-4(3H)-ones as nonclassical antifolates.
AID1416384Antibacterial activity against Staphylococcus aureus at 50 ug/ml incubated for 24 hrs by agar well diffusion method2017MedChemComm, Aug-01, Volume: 8, Issue:8
Synthesis and molecular docking studies of xanthone attached amino acids as potential antimicrobial and anti-inflammatory agents.
AID1318935Antibacterial activity against multidrug-resistant/tobramycin-susceptible Pseudomonas aeruginosa isolate 831822016Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
Hybrid Antibiotic Overcomes Resistance in P. aeruginosa by Enhancing Outer Membrane Penetration and Reducing Efflux.
AID1463961Antimycobacterial activity MDR/XDR against Mycobacterium tuberculosis isolate 7357/1998 incubated for 14 days by micromethod2017Bioorganic & medicinal chemistry, 10-15, Volume: 25, Issue:20
Development of water-soluble 3,5-dinitrophenyl tetrazole and oxadiazole antitubercular agents.
AID1422377Cytotoxicity against mouse J774 cells assessed as cell viability at 10 uM after 24 hrs by MTT assay relative to control2018European journal of medicinal chemistry, Sep-05, Volume: 157Broad-spectrum antibacterial amphiphilic aminoglycosides: A new focus on the structure of the lipophilic groups extends the series of active dialkyl neamines.
AID1545127Antibacterial activity against Bacillus cereus by CLSI protocol based method2019Journal of natural products, 08-23, Volume: 82, Issue:8
Antibacterial and Inhibitory Activities against Nitric Oxide Production of Coumaronochromones and Prenylated Isoflavones from
AID1497855Antibacterial activity against Staphylococcus epidermidis ATCC 122282018Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12
Design, synthesis and biological evaluation of benzofuran appended benzothiazepine derivatives as inhibitors of butyrylcholinesterase and antimicrobial agents.
AID1516026Antibacterial activity against Acinetobacter baumannii AB1901 clinical isolate incubated for 18 to 24 hrs by broth microdilution method2019Journal of medicinal chemistry, 08-08, Volume: 62, Issue:15
Design of Trp-Rich Dodecapeptides with Broad-Spectrum Antimicrobial Potency and Membrane-Disruptive Mechanism.
AID1430049Antibacterial activity against Pseudomonas aeruginosa ATCC BAA-427 by broth microdilution method
AID1265779Antibacterial activity against Salmonella assessed as growth inhibition incubated for 24 hrs at 37 degC by agar well diffusion method2016Bioorganic & medicinal chemistry letters, Jan-01, Volume: 26, Issue:1
An efficient green synthesis of 2-arylbenzothiazole analogues as potent antibacterial and anticancer agents.
AID1577339Antimycobacterial activity against multi-drug resistant Mycobacterium tuberculosis 8666/2010 after 14 days2019Journal of medicinal chemistry, 09-12, Volume: 62, Issue:17
Development of 3,5-Dinitrophenyl-Containing 1,2,4-Triazoles and Their Trifluoromethyl Analogues as Highly Efficient Antitubercular Agents Inhibiting Decaprenylphosphoryl-β-d-ribofuranose 2'-Oxidase.
AID1539478Antibacterial activity against Pseudomonas aeruginosa ATCC 15442 clinical isolates after 18 to 20 hrs in aerobic condition by CLSI-based broth microdilution assay
AID1323754Antibacterial activity against Escherichia coli ATCC 25922 after 16 to 20 hrs by broth microdilution method2016Bioorganic & medicinal chemistry, 11-01, Volume: 24, Issue:21
Investigation of C-5 alkynyl (alkynyloxy or hydroxymethyl) and/or N-3 propynyl substituted pyrimidine nucleoside analogs as a new class of antimicrobial agents.
AID1321214Antimicrobial activity against Staphylococcus aureus IFO 3060 at 200 ug/disc measured after 24 hrs by agar disc-diffusion method2016Bioorganic & medicinal chemistry letters, 10-01, Volume: 26, Issue:19
Synthesis, biological evaluation and molecular modeling study of some new methoxylated 2-benzylthio-quinazoline-4(3H)-ones as nonclassical antifolates.
AID1878028Antibacterial activity against Escherichia coli K12 harbouring elongation factor P deltayjeK variant assessed as reduction in bacterial growth at 500 uM incubated for 240 mins by turbidity based analysis2022Bioorganic & medicinal chemistry letters, 03-01, Volume: 59De-novo designed β-lysine derivatives can both augment and diminish the proliferation rates of E. coli through the action of Elongation Factor P.
AID1713877Antibacterial activity against methicillin-resistant Staphylococcus aureus CEMTC 675 assessed as concentration required to inhibit visible growth by CLSI protocol based serial microdilution method2016Bioorganic & medicinal chemistry, 11-15, Volume: 24, Issue:22
Biological evaluation of tetracationic compounds based on two 1,4-diazabicyclo[2.2.2]octane moieties connected by different linkers.
AID1627404Antibacterial activity against methicillin resistant Staphylococcus aureus clinical isolate 10 incubated for 7 to 14 days by microdilution resazurin assay2016Bioorganic & medicinal chemistry, 09-15, Volume: 24, Issue:18
Structure elucidation of anti-methicillin resistant Staphylococcus aureus (MRSA) flavonoids from balsam poplar buds.
AID1422365Antibacterial activity against Staphylococcus aureus SA-1 expressing NorA pump by microdilution assay2018European journal of medicinal chemistry, Sep-05, Volume: 157Broad-spectrum antibacterial amphiphilic aminoglycosides: A new focus on the structure of the lipophilic groups extends the series of active dialkyl neamines.
AID1463958Antimycobacterial activity MDR/XDR against Mycobacterium tuberculosis isolate Praha 131 incubated for 14 days by micromethod2017Bioorganic & medicinal chemistry, 10-15, Volume: 25, Issue:20
Development of water-soluble 3,5-dinitrophenyl tetrazole and oxadiazole antitubercular agents.
AID1360039Antimicrobial activity against Pseudomonas aeruginosa after 18 to 20 hrs by micro broth dilution method2018European journal of medicinal chemistry, Jun-25, Volume: 154Free radical rearrangement synthesis and microbiological evaluation of novel 2-sulfoether-4-quinolone scaffolds as potential antibacterial agents.
AID1867040Antimicrobial activity against Staphylococcus aureus JE2 ssessed as reduction in bacterial growth and measured for 24 hrs by resazurin dye based broth microdilution method
AID1713870Antibacterial activity against Salmonella enterica ATCC 14028 assessed as bacterial growth inhibition by CLSI protocol based serial microdilution method2016Bioorganic & medicinal chemistry, 11-15, Volume: 24, Issue:22
Biological evaluation of tetracationic compounds based on two 1,4-diazabicyclo[2.2.2]octane moieties connected by different linkers.
AID1575403Antibacterial activity against multidrug-resistant Staphylococcus aureus isolate 3797 after 16 hrs by agar diffusion method2019Journal of natural products, 01-25, Volume: 82, Issue:1
Antibacterial Aromatic Polyketides Incorporating the Unusual Amino Acid Enduracididine.
AID1265196Antibacterial activity against methicillin-resistant Staphylococcus aureus NCTC 13616 after 24 hrs by microtiter plate method2015Bioorganic & medicinal chemistry letters, Dec-15, Volume: 25, Issue:24
Synthesis, biological activity evaluation and molecular docking studies of novel coumarin substituted thiazolyl-3-aryl-pyrazole-4-carbaldehydes.
AID1884066Antibacterial activity against Clostridium-ihumii AP5 incubated for 24 hrs by CLSI based broth microdilution method2022Journal of natural products, 06-24, Volume: 85, Issue:6
Chemically Tuning Resveratrol for the Effective Killing of Gram-Positive Pathogens.
AID1416383Antibacterial activity against Staphylococcus aureus at 25 ug/ml incubated for 24 hrs by agar well diffusion method2017MedChemComm, Aug-01, Volume: 8, Issue:8
Synthesis and molecular docking studies of xanthone attached amino acids as potential antimicrobial and anti-inflammatory agents.
AID1323756Antibacterial activity against clinical isolates of Salmonella typhimurium after 16 to 20 hrs by broth microdilution method2016Bioorganic & medicinal chemistry, 11-01, Volume: 24, Issue:21
Investigation of C-5 alkynyl (alkynyloxy or hydroxymethyl) and/or N-3 propynyl substituted pyrimidine nucleoside analogs as a new class of antimicrobial agents.
AID1444332Antibacterial activity against extended spectrum beta-lactamase producing Klebsiella pneumoniae HK14368/08 after 24 hrs by broth microdilution method2017European journal of medicinal chemistry, Apr-21, Volume: 130Structure-activity relationship studies on 3,5-dinitrophenyl tetrazoles as antitubercular agents.
AID1497854Antibacterial activity against Bacillus subtilis ATCC 66332018Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12
Design, synthesis and biological evaluation of benzofuran appended benzothiazepine derivatives as inhibitors of butyrylcholinesterase and antimicrobial agents.
AID1442084Antibacterial activity against Escherichia coli ATCC 25922 after 18 hrs by broth microdilution method2017Journal of medicinal chemistry, 03-23, Volume: 60, Issue:6
Novel Design of Heptad Amphiphiles To Enhance Cell Selectivity, Salt Resistance, Antibiofilm Properties and Their Membrane-Disruptive Mechanism.
AID1497866Antibacterial activity against Shigella dysenteriae PTCC 11882018Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12
Design, synthesis and biological evaluation of benzofuran appended benzothiazepine derivatives as inhibitors of butyrylcholinesterase and antimicrobial agents.
AID1282501Antibacterial activity against clinical isolate polymyxin resistant Pseudomonas aeruginosa PA9704 after 18 hrs by 2 fold serial dilution method2016Journal of medicinal chemistry, Feb-11, Volume: 59, Issue:3
Activity and Predicted Nephrotoxicity of Synthetic Antibiotics Based on Polymyxin B.
AID1442096Cytotoxicity in mouse RAW264.7 cells after 24 hrs by MTT assay2017Journal of medicinal chemistry, 03-23, Volume: 60, Issue:6
Novel Design of Heptad Amphiphiles To Enhance Cell Selectivity, Salt Resistance, Antibiofilm Properties and Their Membrane-Disruptive Mechanism.
AID1416396Antibacterial activity against Klebsiella pneumoniae at 50 ug/ml incubated for 24 hrs by agar well diffusion method2017MedChemComm, Aug-01, Volume: 8, Issue:8
Synthesis and molecular docking studies of xanthone attached amino acids as potential antimicrobial and anti-inflammatory agents.
AID1625612Antibacterial activity against Klebsiella pneumoniae KPC2ST258 infected in Swiss Webster mouse assessed as survival time at 100 mg/kg, sc administered 1, 12 and 24 hrs post infection measured every 12 hrs for 7 days2016Journal of medicinal chemistry, 06-09, Volume: 59, Issue:11
Thiolactomycin-Based Inhibitors of Bacterial β-Ketoacyl-ACP Synthases with in Vivo Activity.
AID1296387Antimycobacterial activity against multi drug resistant Mycobacterium tuberculosis Praha 4 after 14 days by microdilution method2016Journal of medicinal chemistry, Mar-24, Volume: 59, Issue:6
Development of 3,5-Dinitrobenzylsulfanyl-1,3,4-oxadiazoles and Thiadiazoles as Selective Antitubercular Agents Active Against Replicating and Nonreplicating Mycobacterium tuberculosis.
AID1369474Antibacterial activity against Escherichia coli ATCC 25922 after 18 hrs in presence of CaCl2 by broth dilution method2018Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides.
AID1497857Antibacterial activity against Escherichia coli ATCC 10536 assessed as diameter of inhibition zone at 200 ug per disc after 24 hrs by agar disc diffusion method2018Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12
Design, synthesis and biological evaluation of benzofuran appended benzothiazepine derivatives as inhibitors of butyrylcholinesterase and antimicrobial agents.
AID1471211Antibacterial activity against Staphylococcus aureus ATCC 25923 by spectrophotometric method2017Bioorganic & medicinal chemistry letters, 07-01, Volume: 27, Issue:13
Diversity-oriented sustainable synthesis of antimicrobial spiropyrrolidine/thiapyrrolizidine oxindole derivatives: New ligands for a metallo-β-lactamase from Klebsiella pneumonia.
AID1524042Antimicrobial activity against Pseudomonas aeruginosa 25349 clinical isolates after 24 hrs by NCCLS-protocol based assay2019Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5
Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria.
AID1713872Antibacterial activity against Citrobacter freundii ATCC 8090 assessed as bacterial growth inhibition by CLSI protocol based serial microdilution method2016Bioorganic & medicinal chemistry, 11-15, Volume: 24, Issue:22
Biological evaluation of tetracationic compounds based on two 1,4-diazabicyclo[2.2.2]octane moieties connected by different linkers.
AID1442087Antibacterial activity against Pseudomonas aeruginosa CICC 10419 after 18 hrs by broth microdilution method2017Journal of medicinal chemistry, 03-23, Volume: 60, Issue:6
Novel Design of Heptad Amphiphiles To Enhance Cell Selectivity, Salt Resistance, Antibiofilm Properties and Their Membrane-Disruptive Mechanism.
AID1282503Antibacterial activity against clinical isolate carbapenem and polymyxin resistant Klebsiella pneumoniae Koprana 100650661:1 after 18 hrs by 2 fold serial dilution method2016Journal of medicinal chemistry, Feb-11, Volume: 59, Issue:3
Activity and Predicted Nephrotoxicity of Synthetic Antibiotics Based on Polymyxin B.
AID1265776Antibacterial activity against Staphylococcus aureus assessed as growth inhibition incubated for 24 hrs at 37 degC by agar well diffusion method2016Bioorganic & medicinal chemistry letters, Jan-01, Volume: 26, Issue:1
An efficient green synthesis of 2-arylbenzothiazole analogues as potent antibacterial and anticancer agents.
AID1653583Anti-leprotic activity against Mycobacterium leprae infected in BALB/c weanling mouse assessed as bacteria killing at 20 mg/kg, ip administrated for 60 days and measured after 1 year by most probable number technique analysis relative to control2019Bioorganic & medicinal chemistry, 07-01, Volume: 27, Issue:13
Insights of synthetic analogues of anti-leprosy agents.
AID1391498Antibacterial activity against Staphylococcus aureus after 24 hrs by UV-vis spectrophotometric method
AID1369440Bactericidal activity against methicillin-resistant Staphylococcus aureus ATCC 43302018Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides.
AID1567131Antimicrobial activity against Staphylococcus aureus HA W231 ST45 incubated for 20 hrs by microdilution method2019European journal of medicinal chemistry, Sep-15, Volume: 178Design, synthesis and biological evaluation of antimicrobial diarylimine and -amine compounds targeting the interaction between the bacterial NusB and NusE proteins.
AID1539441Antibacterial activity against methicillin-resistant Staphylococcus aureus NRS384-USA300 clinical isolates after 18 to 20 hrs in aerobic condition by CLSI protocol based broth microdilution assay
AID1567118Antimicrobial activity against Enterococcus faecium ATCC 19433 incubated for 20 hrs by microdilution method2019European journal of medicinal chemistry, Sep-15, Volume: 178Design, synthesis and biological evaluation of antimicrobial diarylimine and -amine compounds targeting the interaction between the bacterial NusB and NusE proteins.
AID1575404Antibacterial activity against Staphylococcus haemolyticus isolate 1730 after 16 hrs by agar diffusion method2019Journal of natural products, 01-25, Volume: 82, Issue:1
Antibacterial Aromatic Polyketides Incorporating the Unusual Amino Acid Enduracididine.
AID1713879Antibacterial activity against methicillin-resistant Staphylococcus aureus CEMTC 707 assessed as concentration required to inhibit visible growth by CLSI protocol based serial microdilution method2016Bioorganic & medicinal chemistry, 11-15, Volume: 24, Issue:22
Biological evaluation of tetracationic compounds based on two 1,4-diazabicyclo[2.2.2]octane moieties connected by different linkers.
AID1444328Antibacterial activity against Escherichia coli ATCC 8739 after 24 hrs by broth microdilution method2017European journal of medicinal chemistry, Apr-21, Volume: 130Structure-activity relationship studies on 3,5-dinitrophenyl tetrazoles as antitubercular agents.
AID1511407Antibacterial activity against Pseudomonas aeruginosa assessed as reduction in bacterial cell growth incubated for 24 hrs by filter paper assay2019Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
Synthesis and biological evaluation of calycanthaceous alkaloid analogs.
AID1296386Antimycobacterial activity against multi drug resistant Mycobacterium tuberculosis Praha 1 after 14 days by microdilution method2016Journal of medicinal chemistry, Mar-24, Volume: 59, Issue:6
Development of 3,5-Dinitrobenzylsulfanyl-1,3,4-oxadiazoles and Thiadiazoles as Selective Antitubercular Agents Active Against Replicating and Nonreplicating Mycobacterium tuberculosis.
AID1776894Antibacterial activity against Pseudomonas aeruginosa MTCC441 at 5 ug/ml2021Bioorganic & medicinal chemistry letters, 07-15, Volume: 44Design, synthesis and antimicrobial activity of novel 2-aminothiophene containing cyclic and heterocyclic moieties.
AID1369431Antibacterial activity against Staphylococcus aureus ATCC 29213 after 24 hrs2018Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides.
AID1356826Antimicrobial activity against Klebsiella pneumoniae NCTC 13438 by broth microdilution method2018Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
Total Synthesis and Structure-Activity Relationships Study of Odilorhabdins, a New Class of Peptides Showing Potent Antibacterial Activity.
AID1870162Antibacterial activity against wild type Staphylococcus aureus 4968/C assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay2022Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14
LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials.
AID1567122Antimicrobial activity against Pseudomonas aeruginosa ATCC 27853 incubated for 20 hrs by microdilution method2019European journal of medicinal chemistry, Sep-15, Volume: 178Design, synthesis and biological evaluation of antimicrobial diarylimine and -amine compounds targeting the interaction between the bacterial NusB and NusE proteins.
AID1391500Antibacterial activity against Escherichia coli after 24 hrs by UV-vis spectrophotometric method
AID1809818Antimicrobial activity against Pseudomonas aeruginosa ATCC BAA-427 assessed as inhibition of bacterial growth by broth dilution method2021Journal of medicinal chemistry, 10-28, Volume: 64, Issue:20
Tandem Repeat of a Short Human Chemerin-Derived Peptide and Its Nontoxic d-Lysine-Containing Enantiomer Display Broad-Spectrum Antimicrobial and Antitubercular Activities.
AID1393152Antimicrobial activity against Stenotrophomonas maltophilia L3030 by broth microdilution method2017Journal of natural products, 04-28, Volume: 80, Issue:4
Antibacterial Paramagnetic Quinones from Actinoallomurus.
AID1524035Antimicrobial activity against Escherichia coli K88 after 24 hrs by NCCLS-protocol based assay2019Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5
Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria.
AID1369472Antibacterial activity against Escherichia coli ATCC 25922 after 18 hrs in presence of NH4Cl by broth dilution method2018Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides.
AID1617784Antibacterial activity against Escherichia coli ATCC 25922 incubated for 18 hrs by dilution antimicrobial susceptibility test
AID1356827Antimicrobial activity against Klebsiella pneumoniae NCTC 13439 by broth microdilution method2018Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
Total Synthesis and Structure-Activity Relationships Study of Odilorhabdins, a New Class of Peptides Showing Potent Antibacterial Activity.
AID1271796Antibacterial activity against Proteus vulgaris ATCC 13315 after 24 hrs by broth microdilution method2016Bioorganic & medicinal chemistry letters, Jan-15, Volume: 26, Issue:2
Synthesis, antibacterial and cytotoxic activities of new biflorin-based hydrazones and oximes.
AID1730950Antibacterial activity against Streptococcus pyogenes MTCC 442 assessed as bacterial growth inhibition2021Bioorganic & medicinal chemistry letters, 03-15, Volume: 36Structure based design, synthesis, and biological evaluation of imidazole derivatives targeting dihydropteroate synthase enzyme.
AID1322250Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 by microdilution method2016Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20
New Broad-Spectrum Antibacterial Amphiphilic Aminoglycosides Active against Resistant Bacteria: From Neamine Derivatives to Smaller Neosamine Analogues.
AID1430047Antibacterial activity against Staphylococcus aureus ATCC 29213 by broth microdilution method
AID1609313Bactericidal activity against Pseudomonas aeruginosa ATCC 278532019European journal of medicinal chemistry, Nov-15, Volume: 182Phenylthiazoles with nitrogenous side chain: An approach to overcome molecular obesity.
AID1356823Antimicrobial activity against Klebsiella pneumoniae ATCC 13883 by broth microdilution method2018Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
Total Synthesis and Structure-Activity Relationships Study of Odilorhabdins, a New Class of Peptides Showing Potent Antibacterial Activity.
AID1393150Antimicrobial activity against Pseudomonas aeruginosa ATCC 27853 by broth microdilution method2017Journal of natural products, 04-28, Volume: 80, Issue:4
Antibacterial Paramagnetic Quinones from Actinoallomurus.
AID1540928Effect on growth of Lactobacillus casei ATCC 334 measured after 48 hrs in anaerobic conditions by CLSI method
AID1356820Antimicrobial activity against Escherichia coli ATCC 25922 by broth microdilution method2018Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
Total Synthesis and Structure-Activity Relationships Study of Odilorhabdins, a New Class of Peptides Showing Potent Antibacterial Activity.
AID1318933Antibacterial activity against multidrug-resistant/tobramycin-susceptible Pseudomonas aeruginosa isolate 791992016Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
Hybrid Antibiotic Overcomes Resistance in P. aeruginosa by Enhancing Outer Membrane Penetration and Reducing Efflux.
AID1497859Antibacterial activity against Klebsiella pneumoniae ATCC 10031 assessed as diameter of inhibition zone at 200 ug per disc after 24 hrs by agar disc diffusion method2018Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12
Design, synthesis and biological evaluation of benzofuran appended benzothiazepine derivatives as inhibitors of butyrylcholinesterase and antimicrobial agents.
AID1442091Antibacterial activity against gentamicin-resistant Pseudomonas aeruginosa 11421 after 18 hrs by broth microdilution method2017Journal of medicinal chemistry, 03-23, Volume: 60, Issue:6
Novel Design of Heptad Amphiphiles To Enhance Cell Selectivity, Salt Resistance, Antibiofilm Properties and Their Membrane-Disruptive Mechanism.
AID1282494Antibacterial activity against Escherichia coli ATCC 25922 after 18 hrs by 2 fold serial dilution method2016Journal of medicinal chemistry, Feb-11, Volume: 59, Issue:3
Activity and Predicted Nephrotoxicity of Synthetic Antibiotics Based on Polymyxin B.
AID1677474Antibacterial activity against Bacillus subtilis2020Bioorganic & medicinal chemistry letters, 11-01, Volume: 30, Issue:21
New antibacterial cadiolide analogues active against antibiotic-resistant strains.
AID1360037Antimicrobial activity against Staphylococcus aureus after 18 to 20 hrs by micro broth dilution method2018European journal of medicinal chemistry, Jun-25, Volume: 154Free radical rearrangement synthesis and microbiological evaluation of novel 2-sulfoether-4-quinolone scaffolds as potential antibacterial agents.
AID1609252Antibacterial activity against Acinetobacter baumannii ATCC 196062019European journal of medicinal chemistry, Nov-15, Volume: 182Phenylthiazoles with nitrogenous side chain: An approach to overcome molecular obesity.
AID1435649Antimycobacterial activity against multidrug-resistant Mycobacterium tuberculosis Praha 4 after 14 days by micromethod2017European journal of medicinal chemistry, Jan-27, Volume: 126S-substituted 3,5-dinitrophenyl 1,3,4-oxadiazole-2-thiols and tetrazole-5-thiols as highly efficient antitubercular agents.
AID1878027Antibacterial activity against Escherichia coli K12 harbouring wild type elongation factor P at 500 uM incubated for 240 mins by turbidity based analysis2022Bioorganic & medicinal chemistry letters, 03-01, Volume: 59De-novo designed β-lysine derivatives can both augment and diminish the proliferation rates of E. coli through the action of Elongation Factor P.
AID1271795Antibacterial activity against Enterococcus faecalis ATCC 4083 after 24 hrs by broth microdilution method2016Bioorganic & medicinal chemistry letters, Jan-15, Volume: 26, Issue:2
Synthesis, antibacterial and cytotoxic activities of new biflorin-based hydrazones and oximes.
AID1265194Antibacterial activity against Klebsiella pneumoniae ATCC 43816 after 24 hrs by microtiter plate method2015Bioorganic & medicinal chemistry letters, Dec-15, Volume: 25, Issue:24
Synthesis, biological activity evaluation and molecular docking studies of novel coumarin substituted thiazolyl-3-aryl-pyrazole-4-carbaldehydes.
AID1497853Antibacterial activity against Staphylococcus aureus ATCC 297372018Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12
Design, synthesis and biological evaluation of benzofuran appended benzothiazepine derivatives as inhibitors of butyrylcholinesterase and antimicrobial agents.
AID1435651Antimycobacterial activity against multidrug-resistant Mycobacterium tuberculosis 9449/2007 after 14 days by micromethod2017European journal of medicinal chemistry, Jan-27, Volume: 126S-substituted 3,5-dinitrophenyl 1,3,4-oxadiazole-2-thiols and tetrazole-5-thiols as highly efficient antitubercular agents.
AID1884053Antibacterial activity against Bacillus cereus ATCC 14579 incubated for 20 hrs by CLSI based broth microdilution method2022Journal of natural products, 06-24, Volume: 85, Issue:6
Chemically Tuning Resveratrol for the Effective Killing of Gram-Positive Pathogens.
AID1462761Antimicrobial activity against Staphylococcus aureus ATCC 25923 assessed as growth inhibition incubated overnight at 37degC by visual and photometry based method2017Bioorganic & medicinal chemistry, 10-15, Volume: 25, Issue:20
Methyl propiolate and 3-butynone: Starting points for synthesis of amphiphilic 1,2,3-triazole peptidomimetics for antimicrobial evaluation.
AID1575409Antibacterial activity against Streptococcus pneumoniae isolate 44 after 16 hrs by agar diffusion method2019Journal of natural products, 01-25, Volume: 82, Issue:1
Antibacterial Aromatic Polyketides Incorporating the Unusual Amino Acid Enduracididine.
AID1271950Antibacterial activity against Escherichia coli assessed as growth inhibition at 1 mg/ml by drug sensitive assay2016Bioorganic & medicinal chemistry letters, Jan-15, Volume: 26, Issue:2
Novel skeleton compound Allomyrinanoid A and two purine alkaloids from the adult of Allomyrina dichotoma L.
AID1713885Antibacterial activity against methicillin-resistant Staphylococcus aureus CEMTC 1733 assessed as concentration required to inhibit visible growth by CLSI protocol based serial microdilution method2016Bioorganic & medicinal chemistry, 11-15, Volume: 24, Issue:22
Biological evaluation of tetracationic compounds based on two 1,4-diazabicyclo[2.2.2]octane moieties connected by different linkers.
AID1282519Cytotoxicity against human HepG2 cells after 24 hrs by resazurin assay2016Journal of medicinal chemistry, Feb-11, Volume: 59, Issue:3
Activity and Predicted Nephrotoxicity of Synthetic Antibiotics Based on Polymyxin B.
AID1435648Antimycobacterial activity against multidrug-resistant Mycobacterium tuberculosis Praha 1 after 14 days by micromethod2017European journal of medicinal chemistry, Jan-27, Volume: 126S-substituted 3,5-dinitrophenyl 1,3,4-oxadiazole-2-thiols and tetrazole-5-thiols as highly efficient antitubercular agents.
AID1435652Antimycobacterial activity against multidrug-resistant Mycobacterium tuberculosis 234/2005 after 14 days by micromethod2017European journal of medicinal chemistry, Jan-27, Volume: 126S-substituted 3,5-dinitrophenyl 1,3,4-oxadiazole-2-thiols and tetrazole-5-thiols as highly efficient antitubercular agents.
AID1501241Antibacterial activity against Bacillus cereus ATCC 14579 measured after overnight incubation2017Journal of natural products, 09-22, Volume: 80, Issue:9
Thermoactinoamide A, an Antibiotic Lipophilic Cyclopeptide from the Icelandic Thermophilic Bacterium Thermoactinomyces vulgaris.
AID1516024Antibacterial activity against Staphylococcus epidermidis ATCC 12228 incubated for 18 to 24 hrs by broth microdilution method2019Journal of medicinal chemistry, 08-08, Volume: 62, Issue:15
Design of Trp-Rich Dodecapeptides with Broad-Spectrum Antimicrobial Potency and Membrane-Disruptive Mechanism.
AID1318934Antibacterial activity against multidrug-resistant/tobramycin-susceptible Pseudomonas aeruginosa isolate 806212016Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
Hybrid Antibiotic Overcomes Resistance in P. aeruginosa by Enhancing Outer Membrane Penetration and Reducing Efflux.
AID1369471Antibacterial activity against Escherichia coli ATCC 25922 after 18 hrs in presence of KCl by broth dilution method2018Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides.
AID1282520Cytotoxicity against HEK293 cells after 24 hrs by resazurin assay2016Journal of medicinal chemistry, Feb-11, Volume: 59, Issue:3
Activity and Predicted Nephrotoxicity of Synthetic Antibiotics Based on Polymyxin B.
AID1878474Antibacterial activity against Staphylococcus aureus ATCC 29213 assessed as inhibition of bacterial growth incubated for 90 mins by serial dilution assay2022European journal of medicinal chemistry, Mar-05, Volume: 231Systematic comparison of activity and mechanism of antimicrobial peptides against nosocomial pathogens.
AID1435650Antimycobacterial activity against multidrug-resistant Mycobacterium tuberculosis Praha 131 after 14 days by micromethod2017European journal of medicinal chemistry, Jan-27, Volume: 126S-substituted 3,5-dinitrophenyl 1,3,4-oxadiazole-2-thiols and tetrazole-5-thiols as highly efficient antitubercular agents.
AID1516019Antibacterial activity against Staphylococcus aureus ATCC 25923 incubated for 18 to 24 hrs by broth microdilution method2019Journal of medicinal chemistry, 08-08, Volume: 62, Issue:15
Design of Trp-Rich Dodecapeptides with Broad-Spectrum Antimicrobial Potency and Membrane-Disruptive Mechanism.
AID1278311Antimicrobial activity against Pseudomonas aeruginosa 27853 after 18 hrs by microdilution method in presence of 4 uM iron2016European journal of medicinal chemistry, Mar-03, Volume: 110Design, synthesis and biological evaluation of monobactams as antibacterial agents against gram-negative bacteria.
AID1545130Antibacterial activity against Pseudomonas aeruginosa by CLSI protocol based method2019Journal of natural products, 08-23, Volume: 82, Issue:8
Antibacterial and Inhibitory Activities against Nitric Oxide Production of Coumaronochromones and Prenylated Isoflavones from
AID1609302Antibacterial activity against Escherichia coli BW251132019European journal of medicinal chemistry, Nov-15, Volume: 182Phenylthiazoles with nitrogenous side chain: An approach to overcome molecular obesity.
AID1695935Antibacterial activity against Proteus vulgaris ATCC 29213 incubated for 24 hrs by broth dilution method2019European journal of medicinal chemistry, Apr-15, Volume: 168Comprehensive review on the anti-bacterial activity of 1,2,3-triazole hybrids.
AID1322251Antibacterial activity against AAC6'-2A expressing Pseudomonas aeruginosa F03 by microdilution method2016Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20
New Broad-Spectrum Antibacterial Amphiphilic Aminoglycosides Active against Resistant Bacteria: From Neamine Derivatives to Smaller Neosamine Analogues.
AID1653076Antibacterial activity against Bacillus cereus assessed as zone of inhibition at 100 ug/ml2019European journal of medicinal chemistry, Feb-15, Volume: 164Isatin derivatives and their anti-bacterial activities.
AID1575412Antibacterial activity against Propionibacterium acnes ATCC 25746 after 16 hrs by agar diffusion method2019Journal of natural products, 01-25, Volume: 82, Issue:1
Antibacterial Aromatic Polyketides Incorporating the Unusual Amino Acid Enduracididine.
AID1824273Antimicrobial activity against Escherichia coli clinical isolate T2228 expressing VIM-1 assessed as inhibition of bacterial growth by CLSI protocol based broth microdilution assay2022European journal of medicinal chemistry, Jan-15, Volume: 228Nitroxoline and its derivatives are potent inhibitors of metallo-β-lactamases.
AID1524061Bactericidal activity against Escherichia coli ATCC 25922 incubated for 4 hrs followed by culture spread on agar plates and cultured overnight2019Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5
Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria.
AID1856911Antibacterial activity against Staphylococcus aureus ATCC 25923 assessed as fold increase in MIC measured after 15 passages by resistance development assay2022Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20
Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1878476Antibacterial activity against Enterococcus faecalis ATCC 29212 assessed as inhibition of bacterial growth incubated for 90 mins by serial dilution assay2022European journal of medicinal chemistry, Mar-05, Volume: 231Systematic comparison of activity and mechanism of antimicrobial peptides against nosocomial pathogens.
AID1271951Antibacterial activity against Escherichia coli assessed as growth inhibition at 10 mg/ml by drug sensitive assay2016Bioorganic & medicinal chemistry letters, Jan-15, Volume: 26, Issue:2
Novel skeleton compound Allomyrinanoid A and two purine alkaloids from the adult of Allomyrina dichotoma L.
AID1870163Antibacterial activity against wild type Staphylococcus aureus 5017/C assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay2022Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14
LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials.
AID1430436Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 after overnight incubation by photometric method2017Bioorganic & medicinal chemistry letters, 03-01, Volume: 27, Issue:5
Synthesis and antimicrobial evaluation of cationic low molecular weight amphipathic 1,2,3-triazoles.
AID1539465Antibacterial activity against Escherichia coli ATCC 25922 clinical isolates after 18 to 20 hrs in aerobic condition by CLSI-based broth microdilution assay
AID1713868Antibacterial activity against Escherichia coli ATCC 25922 assessed as bacterial growth inhibition by CLSI protocol based serial microdilution method2016Bioorganic & medicinal chemistry, 11-15, Volume: 24, Issue:22
Biological evaluation of tetracationic compounds based on two 1,4-diazabicyclo[2.2.2]octane moieties connected by different linkers.
AID1578419Antimicrobial activity against Escherichia coli JW55031 harboring deltatolC mutant by broth liquid microdilution method2020European journal of medicinal chemistry, Jan-01, Volume: 185Modifying the lipophilic part of phenylthiazole antibiotics to control their drug-likeness.
AID1442085Antibacterial activity against Staphylococcus aureus ATCC 29213 after 18 hrs by broth microdilution method2017Journal of medicinal chemistry, 03-23, Volume: 60, Issue:6
Novel Design of Heptad Amphiphiles To Enhance Cell Selectivity, Salt Resistance, Antibiofilm Properties and Their Membrane-Disruptive Mechanism.
AID1677470Antibacterial activity against Staphylococcus aureus NCTC124932020Bioorganic & medicinal chemistry letters, 11-01, Volume: 30, Issue:21
New antibacterial cadiolide analogues active against antibiotic-resistant strains.
AID1524047Antimicrobial activity against Klebsiella pneumoniae after 24 hrs by NCCLS-protocol based assay2019Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5
Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria.
AID1539462Antibacterial activity against Acinetobacter baumannii NR 17786 clinical isolates after 18 to 20 hrs in aerobic condition by CLSI-based broth microdilution assay
AID1592958Antibacterial activity against multi-drug resistant Escherichia coli NMI 3898/15 assessed as reduction in microbial growth incubated for 20 hrs2019European journal of medicinal chemistry, Apr-15, Volume: 168Microwave-assisted solid-phase synthesis of antisense acpP peptide nucleic acid-peptide conjugates active against colistin- and tigecycline-resistant E. coli and K. pneumoniae.
AID1870136Antibacterial activity against antibiotic resistant Staphylococcus aureus 77/CF assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay2022Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14
LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials.
AID1540929Effect on growth of Lactobacillus crispatus JV-V01 HM 103 measured after 48 hrs in anaerobic conditions by CLSI method
AID1585675Antibiofilm activity against methicillin-resistant Staphylococcus aureus at 2 times MIC after 24 hrs by crystal violet staining-based UV-visible spectrophotometric analysis2019European journal of medicinal chemistry, Jan-15, Volume: 162Discovery of novel arylethenesulfonyl fluorides as potential candidates against methicillin-resistant of Staphylococcus aureus (MRSA) for overcoming multidrug resistance of bacterial infections.
AID1689768Antibacterial activity against Escherichia coli ATCC 259222020European journal of medicinal chemistry, Mar-01, Volume: 189Simple amphiphilic α-hydrazido acids: Rational design, synthesis, and in vitro bioactivity profile of a novel class of potential antimicrobial compounds.
AID1322248Antibacterial activity against NorA expressing Staphylococcus aureus 1 by microdilution method2016Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20
New Broad-Spectrum Antibacterial Amphiphilic Aminoglycosides Active against Resistant Bacteria: From Neamine Derivatives to Smaller Neosamine Analogues.
AID1778063Antibacterial activity against Enterococcus faecalis ATCC 19433 assessed as inhibition of bacterial growth measured after 16 to 20 hrs by CLSI broth microdilution method
AID1695925Antibacterial activity against Bacillus subtilis ATCC 6633 incubated for 24 hrs by broth dilution method2019European journal of medicinal chemistry, Apr-15, Volume: 168Comprehensive review on the anti-bacterial activity of 1,2,3-triazole hybrids.
AID1713881Antibacterial activity against methicillin-resistant Staphylococcus aureus CEMTC 1695 assessed as concentration required to inhibit visible growth by CLSI protocol based serial microdilution method2016Bioorganic & medicinal chemistry, 11-15, Volume: 24, Issue:22
Biological evaluation of tetracationic compounds based on two 1,4-diazabicyclo[2.2.2]octane moieties connected by different linkers.
AID1676982Antimicrobial activity against Escherichia coli BW25113 harboring TolC mutant assessed as reduction in microbial growth after 48 hrs by CLSI based broth microdilution method
AID1759608Antibacterial activity against methicillin resistant Staphylococcus aureus ATCC 700699 persisters assessed as reduction in viability at 64 times MIC by colony counting method2021European journal of medicinal chemistry, Jul-05, Volume: 2194-4-(Anilinomethyl)-3-[4-(trifluoromethyl)phenyl]-1H-pyrazol-1-ylbenzoic acid derivatives as potent anti-gram-positive bacterial agents.
AID1265198Antibacterial activity against Bacillus cereus ATCC 14579 after 24 hrs by microtiter plate method2015Bioorganic & medicinal chemistry letters, Dec-15, Volume: 25, Issue:24
Synthesis, biological activity evaluation and molecular docking studies of novel coumarin substituted thiazolyl-3-aryl-pyrazole-4-carbaldehydes.
AID1369430Antibacterial activity against Salmonella pullorum ATCC 7913 after 24 hrs2018Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides.
AID1567138Antimicrobial activity against CA-methicillin-resistant Staphylococcus aureus W48 ST217 incubated for 20 hrs by microdilution method2019European journal of medicinal chemistry, Sep-15, Volume: 178Design, synthesis and biological evaluation of antimicrobial diarylimine and -amine compounds targeting the interaction between the bacterial NusB and NusE proteins.
AID1689207Antibacterial activity against Escherichia coli BW25113 assessed as reduction in bacterial growth by CLSI based broth microdilution method2020European journal of medicinal chemistry, Mar-01, Volume: 189Oxadiazolylthiazoles as novel and selective antifungal agents.
AID1296384Antimycobacterial activity against multi drug resistant Mycobacterium tuberculosis 9449/2007 after 14 days by microdilution method2016Journal of medicinal chemistry, Mar-24, Volume: 59, Issue:6
Development of 3,5-Dinitrobenzylsulfanyl-1,3,4-oxadiazoles and Thiadiazoles as Selective Antitubercular Agents Active Against Replicating and Nonreplicating Mycobacterium tuberculosis.
AID1809586Antibacterial activity against Salmonella typhi ATCC 6539 assessed as bacterial growth inhibition2021Bioorganic & medicinal chemistry letters, 11-15, Volume: 52Synthesis, anti-microbial, toxicity and molecular docking studies of N-nitroso-N-phenylhydroxylamine (cupferron) and its derivatives.
AID1524045Antimicrobial activity against Salmonella pullorum C7913 after 24 hrs by NCCLS-protocol based assay2019Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5
Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria.
AID1296388Antimycobacterial activity against multi drug resistant Mycobacterium tuberculosis Praha 131 after 14 days by microdilution method2016Journal of medicinal chemistry, Mar-24, Volume: 59, Issue:6
Development of 3,5-Dinitrobenzylsulfanyl-1,3,4-oxadiazoles and Thiadiazoles as Selective Antitubercular Agents Active Against Replicating and Nonreplicating Mycobacterium tuberculosis.
AID1853595Bactericidal activity against Staphylococcus aureus ATCC 700699 assessed as bacteria elimination at 4 times MIC and measured after 6 hrs by time-kill assay2021RSC medicinal chemistry, Oct-20, Volume: 12, Issue:10
Design, synthesis, and antibacterial activity of
AID1393146Antimicrobial activity against hyperpermeable Escherichia coli G1640 by broth microdilution method2017Journal of natural products, 04-28, Volume: 80, Issue:4
Antibacterial Paramagnetic Quinones from Actinoallomurus.
AID1689766Antibacterial activity against Enterococcus faecalis ATCC 292122020European journal of medicinal chemistry, Mar-01, Volume: 189Simple amphiphilic α-hydrazido acids: Rational design, synthesis, and in vitro bioactivity profile of a novel class of potential antimicrobial compounds.
AID1516023Antibacterial activity against Escherichia coli ATCC 25922 incubated for 18 to 24 hrs by broth microdilution method2019Journal of medicinal chemistry, 08-08, Volume: 62, Issue:15
Design of Trp-Rich Dodecapeptides with Broad-Spectrum Antimicrobial Potency and Membrane-Disruptive Mechanism.
AID1539442Antimicrobial activity against Escherichia coli JW55031 harboring deltatolC mutant after 18 to 20 hrs in aerobic condition by CLSI protocol based broth microdilution assay
AID1369434Antibacterial activity against Staphylococcus aureus ATCC 25923 after 24 hrs2018Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides.
AID1878472Antibacterial activity against Escherichia coli BAA3051 assessed as inhibition of bacterial growth incubated for 90 mins by serial dilution assay2022European journal of medicinal chemistry, Mar-05, Volume: 231Systematic comparison of activity and mechanism of antimicrobial peptides against nosocomial pathogens.
AID1271799Antibacterial activity against Staphylococcus aureus 358 after 24 hrs by broth microdilution method2016Bioorganic & medicinal chemistry letters, Jan-15, Volume: 26, Issue:2
Synthesis, antibacterial and cytotoxic activities of new biflorin-based hydrazones and oximes.
AID1585677Antibiofilm activity against methicillin-resistant Staphylococcus aureus planktonic biofilm assessed as optical density at 492 nm at MIC after 24 hrs by crystal violet staining-based UV-visible spectrophotometric analysis2019European journal of medicinal chemistry, Jan-15, Volume: 162Discovery of novel arylethenesulfonyl fluorides as potential candidates against methicillin-resistant of Staphylococcus aureus (MRSA) for overcoming multidrug resistance of bacterial infections.
AID1282502Antibacterial activity against clinical isolate carbapenem and polymyxin resistant Acinetobacter baumannii Ptyela 100734512:2 after 18 hrs by 2 fold serial dilution method2016Journal of medicinal chemistry, Feb-11, Volume: 59, Issue:3
Activity and Predicted Nephrotoxicity of Synthetic Antibiotics Based on Polymyxin B.
AID1416391Antibacterial activity against Escherichia coli at 25 ug/ml incubated for 24 hrs by agar well diffusion method2017MedChemComm, Aug-01, Volume: 8, Issue:8
Synthesis and molecular docking studies of xanthone attached amino acids as potential antimicrobial and anti-inflammatory agents.
AID1435683Antibacterial activity against extended spectrum beta-lactamase producing Klebsiella pneumoniae HK14368/08 after 24 hrs by broth microdilution method2017European journal of medicinal chemistry, Jan-27, Volume: 126S-substituted 3,5-dinitrophenyl 1,3,4-oxadiazole-2-thiols and tetrazole-5-thiols as highly efficient antitubercular agents.
AID1442086Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 after 18 hrs by broth microdilution method2017Journal of medicinal chemistry, 03-23, Volume: 60, Issue:6
Novel Design of Heptad Amphiphiles To Enhance Cell Selectivity, Salt Resistance, Antibiofilm Properties and Their Membrane-Disruptive Mechanism.
AID1778066Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 assessed as inhibition of bacterial growth measured after 16 to 20 hrs by CLSI broth microdilution method
AID1539469Antibacterial activity against Klebsiella pneumoniae BAA-1706 clinical isolates after 18 to 20 hrs in aerobic condition by CLSI-based broth microdilution assay
AID1524135Bactericidal activity against Acinetobacter baumannii incubated for 4 hrs followed by culture spread on agar plates and cultured overnight2019Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5
Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria.
AID1501182Antibacterial activity against Escherichia coli ATCC 25922 by CLSI method2017Journal of natural products, 09-22, Volume: 80, Issue:9
Tulongicin, an Antibacterial Tri-Indole Alkaloid from a Deep-Water Topsentia sp. Sponge.
AID1853597Bactericidal activity against Staphylococcus aureus ATCC 700699 persisters assessed as log reduction in colony forming unit at 64 times MIC after 4 hrs by colony counting method2021RSC medicinal chemistry, Oct-20, Volume: 12, Issue:10
Design, synthesis, and antibacterial activity of
AID1462769Cytotoxicity against human HepG2 cells incubated for 24 hrs by CellTiter 96 aqueous one solution reagent based assay2017Bioorganic & medicinal chemistry, 10-15, Volume: 25, Issue:20
Methyl propiolate and 3-butynone: Starting points for synthesis of amphiphilic 1,2,3-triazole peptidomimetics for antimicrobial evaluation.
AID1625357Antibacterial activity against Pseudomonas aeruginosa DSM 22644 incubated for 24 hrs by disk diffusion method2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Antibacterial Azaphilones from an Endophytic Fungus, Colletotrichum sp. BS4.
AID1391489Antibacterial activity against Bacillus subtilis assessed as diameter of inhibition zone measured after 24 hrs by agar well diffusion method
AID1627397Antibacterial activity against methicillin resistant Staphylococcus aureus clinical isolate 3 incubated for 7 to 14 days by microdilution resazurin assay2016Bioorganic & medicinal chemistry, 09-15, Volume: 24, Issue:18
Structure elucidation of anti-methicillin resistant Staphylococcus aureus (MRSA) flavonoids from balsam poplar buds.
AID1318923Antibacterial activity against multidrug/extremely drug-resistant/colistin-susceptible Pseudomonas aeruginosa isolate 264-1043542016Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
Hybrid Antibiotic Overcomes Resistance in P. aeruginosa by Enhancing Outer Membrane Penetration and Reducing Efflux.
AID1783238Antibacterial activity against Pseudomonas aeruginosa DSMPA14 assessed as inhibition of bacterial growth by broth microdilution method
AID1585530Antibacterial activity against Escherichia coli ATCC 11229 after 24 hrs by broth dilution method2019European journal of medicinal chemistry, Jan-15, Volume: 162Benzofuran derivatives and their anti-tubercular, anti-bacterial activities.
AID1567132Antimicrobial activity against CA-methicillin-resistant Staphylococcus aureus W47 ST30 incubated for 20 hrs by microdilution method2019European journal of medicinal chemistry, Sep-15, Volume: 178Design, synthesis and biological evaluation of antimicrobial diarylimine and -amine compounds targeting the interaction between the bacterial NusB and NusE proteins.
AID1539464Antibacterial activity against Escherichia coli BW25113 clinical isolates after 18 to 20 hrs in aerobic condition by CLSI-based broth microdilution assay
AID1322249Antibacterial activity against healthcare-acquired methicillin-resistant Staphylococcus aureus ATCC 33592 by microdilution method2016Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20
New Broad-Spectrum Antibacterial Amphiphilic Aminoglycosides Active against Resistant Bacteria: From Neamine Derivatives to Smaller Neosamine Analogues.
AID1625354Antibacterial activity against Bacillus subtilis DSM 1088 incubated for 24 hrs by disk diffusion method2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Antibacterial Azaphilones from an Endophytic Fungus, Colletotrichum sp. BS4.
AID1870144Antibacterial activity against wild type Staphylococcus aureus 4883/C assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay2022Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14
LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials.
AID1809595Antibacterial activity against Bacillus subtilis ATCC 23857 assessed as zone of inhibition at 10 mg/ml2021Bioorganic & medicinal chemistry letters, 11-15, Volume: 52Synthesis, anti-microbial, toxicity and molecular docking studies of N-nitroso-N-phenylhydroxylamine (cupferron) and its derivatives.
AID1265777Antibacterial activity against Escherichia coli assessed as growth inhibition incubated for 24 hrs at 37 degC by agar well diffusion method2016Bioorganic & medicinal chemistry letters, Jan-01, Volume: 26, Issue:1
An efficient green synthesis of 2-arylbenzothiazole analogues as potent antibacterial and anticancer agents.
AID1369433Antibacterial activity against Staphylococcus epidermidis ATCC 12228 after 24 hrs2018Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides.
AID1809604Antibacterial activity against Salmonella typhi ATCC 6539 assessed as zone of inhibition at 10 mg/kg2021Bioorganic & medicinal chemistry letters, 11-15, Volume: 52Synthesis, anti-microbial, toxicity and molecular docking studies of N-nitroso-N-phenylhydroxylamine (cupferron) and its derivatives.
AID1630580Antibacterial activity against multidrug resistant Escherichia coli 1137 after 24 hrs by two fold serial dilution method2016Bioorganic & medicinal chemistry letters, 10-15, Volume: 26, Issue:20
Synthesis and antibacterial evaluation of hamacanthin B analogues.
AID1809816Antimicrobial activity against Bacillus subtilis ATCC 6633 assessed as inhibition of bacterial growth by broth dilution method2021Journal of medicinal chemistry, 10-28, Volume: 64, Issue:20
Tandem Repeat of a Short Human Chemerin-Derived Peptide and Its Nontoxic d-Lysine-Containing Enantiomer Display Broad-Spectrum Antimicrobial and Antitubercular Activities.
AID1360043Bactericidal activity against Bacillus cereus after 24 hrs by micro broth dilution method2018European journal of medicinal chemistry, Jun-25, Volume: 154Free radical rearrangement synthesis and microbiological evaluation of novel 2-sulfoether-4-quinolone scaffolds as potential antibacterial agents.
AID1430046Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 700699 by broth microdilution method
AID1321216Antimicrobial activity against Escherichia coli IFO 3301 at 200 ug/disc measured after 24 hrs by agar disc-diffusion method2016Bioorganic & medicinal chemistry letters, 10-01, Volume: 26, Issue:19
Synthesis, biological evaluation and molecular modeling study of some new methoxylated 2-benzylthio-quinazoline-4(3H)-ones as nonclassical antifolates.
AID1575405Antibacterial activity against multidrug-resistant Staphylococcus haemolyticus isolate 1729 after 16 hrs by agar diffusion method2019Journal of natural products, 01-25, Volume: 82, Issue:1
Antibacterial Aromatic Polyketides Incorporating the Unusual Amino Acid Enduracididine.
AID1689769Antibacterial activity against Pseudomonas aeruginosa ATCC 278532020European journal of medicinal chemistry, Mar-01, Volume: 189Simple amphiphilic α-hydrazido acids: Rational design, synthesis, and in vitro bioactivity profile of a novel class of potential antimicrobial compounds.
AID1870161Antibacterial activity against wild type Staphylococcus aureus 4561/A assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay2022Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14
LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials.
AID1323751Antibacterial activity against Staphylococcus aureus ATCC 25923 after 16 to 20 hrs by broth microdilution method2016Bioorganic & medicinal chemistry, 11-01, Volume: 24, Issue:21
Investigation of C-5 alkynyl (alkynyloxy or hydroxymethyl) and/or N-3 propynyl substituted pyrimidine nucleoside analogs as a new class of antimicrobial agents.
AID1282495Antibacterial activity against Klebsiella pneumoniae ATCC 13883 after 18 hrs by 2 fold serial dilution method2016Journal of medicinal chemistry, Feb-11, Volume: 59, Issue:3
Activity and Predicted Nephrotoxicity of Synthetic Antibiotics Based on Polymyxin B.
AID1539471Antibacterial activity against Salmonella enterica NR-170 clinical isolates after 18 to 20 hrs in aerobic condition by CLSI-based broth microdilution assay
AID1577337Antimycobacterial activity against multi-drug resistant Mycobacterium tuberculosis 7357/1998 after 21 days2019Journal of medicinal chemistry, 09-12, Volume: 62, Issue:17
Development of 3,5-Dinitrophenyl-Containing 1,2,4-Triazoles and Their Trifluoromethyl Analogues as Highly Efficient Antitubercular Agents Inhibiting Decaprenylphosphoryl-β-d-ribofuranose 2'-Oxidase.
AID1567135Antimicrobial activity against Staphylococcus aureus USA300/ST8 incubated for 20 hrs by microdilution method2019European journal of medicinal chemistry, Sep-15, Volume: 178Design, synthesis and biological evaluation of antimicrobial diarylimine and -amine compounds targeting the interaction between the bacterial NusB and NusE proteins.
AID1318920Antibacterial activity against multidrug/extremely drug-resistant/colistin-susceptible Pseudomonas aeruginosa isolate 259-969182016Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
Hybrid Antibiotic Overcomes Resistance in P. aeruginosa by Enhancing Outer Membrane Penetration and Reducing Efflux.
AID1369436Bactericidal activity against Escherichia coli 10052018Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides.
AID1265199Bactericidal activity against Escherichia coli ATCC 8739 after 24 hrs2015Bioorganic & medicinal chemistry letters, Dec-15, Volume: 25, Issue:24
Synthesis, biological activity evaluation and molecular docking studies of novel coumarin substituted thiazolyl-3-aryl-pyrazole-4-carbaldehydes.
AID1369473Antibacterial activity against Escherichia coli ATCC 25922 after 18 hrs in presence of MgCl2 by broth dilution method2018Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides.
AID1577331Antimycobacterial activity against XDR Mycobacterium tuberculosis Praha 131 after 14 days2019Journal of medicinal chemistry, 09-12, Volume: 62, Issue:17
Development of 3,5-Dinitrophenyl-Containing 1,2,4-Triazoles and Their Trifluoromethyl Analogues as Highly Efficient Antitubercular Agents Inhibiting Decaprenylphosphoryl-β-d-ribofuranose 2'-Oxidase.
AID1322253Antibacterial activity against triABC deficient Pseudomonas aeruginosa PA406 by microdilution method2016Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20
New Broad-Spectrum Antibacterial Amphiphilic Aminoglycosides Active against Resistant Bacteria: From Neamine Derivatives to Smaller Neosamine Analogues.
AID1318932Antibacterial activity against multidrug-resistant/tobramycin-susceptible Pseudomonas aeruginosa isolate 1085902016Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
Hybrid Antibiotic Overcomes Resistance in P. aeruginosa by Enhancing Outer Membrane Penetration and Reducing Efflux.
AID1809596Antibacterial activity against Bacillus subtilis ATCC 23857 assessed as zone of inhibition at 15 mg/ml2021Bioorganic & medicinal chemistry letters, 11-15, Volume: 52Synthesis, anti-microbial, toxicity and molecular docking studies of N-nitroso-N-phenylhydroxylamine (cupferron) and its derivatives.
AID1884059Antibacterial activity against Enterococcus faecalis LMG 16003 incubated for 20 hrs by CLSI based broth microdilution method2022Journal of natural products, 06-24, Volume: 85, Issue:6
Chemically Tuning Resveratrol for the Effective Killing of Gram-Positive Pathogens.
AID1870141Antibacterial activity against wild type Staphylococcus aureus 4463/A assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay2022Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14
LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials.
AID1539459Antibacterial activity against Acinetobacter baumannii ATCC 19606 clinical isolates after 18 to 20 hrs in aerobic condition by CLSI-based broth microdilution assay
AID1323758Antibacterial activity against Pseudomonas aeruginosa ATCC 13048 after 16 to 20 hrs by broth microdilution method2016Bioorganic & medicinal chemistry, 11-01, Volume: 24, Issue:21
Investigation of C-5 alkynyl (alkynyloxy or hydroxymethyl) and/or N-3 propynyl substituted pyrimidine nucleoside analogs as a new class of antimicrobial agents.
AID1878473Antibacterial activity against Salmonella enterica serovar typhimurium SL1344 assessed as inhibition of bacterial growth incubated for 90 mins by serial dilution assay2022European journal of medicinal chemistry, Mar-05, Volume: 231Systematic comparison of activity and mechanism of antimicrobial peptides against nosocomial pathogens.
AID1430404Antibacterial activity against Pseudomonas aeruginosa M5 after 24 to 48 hrs by macro-broth dilution method2017Bioorganic & medicinal chemistry letters, 03-01, Volume: 27, Issue:5
Methylsulfonyl benzothiazoles (MSBT) derivatives: Search for new potential antimicrobial and anticancer agents.
AID1539468Antibacterial activity against Enterobacter cloacae subsp. cloacae ATCC BAA-1143 clinical isolates after 18 to 20 hrs in aerobic condition by CLSI-based broth microdilution assay
AID1272238Antibacterial activity against Streptococcus pyogenes by broth micro-dilution method2016Bioorganic & medicinal chemistry letters, Feb-01, Volume: 26, Issue:3
Efficiently functionalized oxacalix[4]arenes: Synthesis, characterization and exploration of their biological profile as novel HDAC inhibitors.
AID1393151Antimicrobial activity against Acinetobacter baumannii ATCC 13637 by broth microdilution method2017Journal of natural products, 04-28, Volume: 80, Issue:4
Antibacterial Paramagnetic Quinones from Actinoallomurus.
AID1653075Antibacterial activity against Staphylococcus aureus assessed as zone of inhibition at 100 ug/ml2019European journal of medicinal chemistry, Feb-15, Volume: 164Isatin derivatives and their anti-bacterial activities.
AID1713867Antibacterial activity against Escherichia coli ATCC 25922 assessed as concentration required to inhibit visible growth by CLSI protocol based serial microdilution method2016Bioorganic & medicinal chemistry, 11-15, Volume: 24, Issue:22
Biological evaluation of tetracationic compounds based on two 1,4-diazabicyclo[2.2.2]octane moieties connected by different linkers.
AID1525156Antibacterial activity against Staphylococcus aureus measured after 24 hrs2019Journal of natural products, 05-24, Volume: 82, Issue:5
The Mosaic of Rottlerin: The Sequel.
AID1442093Antibacterial activity against Pseudomonas aeruginosa 21328 clinical isolate after 18 hrs by broth microdilution method2017Journal of medicinal chemistry, 03-23, Volume: 60, Issue:6
Novel Design of Heptad Amphiphiles To Enhance Cell Selectivity, Salt Resistance, Antibiofilm Properties and Their Membrane-Disruptive Mechanism.
AID1442095Antibacterial activity against Pseudomonas aeruginosa 26305 clinical isolate after 18 hrs by broth microdilution method2017Journal of medicinal chemistry, 03-23, Volume: 60, Issue:6
Novel Design of Heptad Amphiphiles To Enhance Cell Selectivity, Salt Resistance, Antibiofilm Properties and Their Membrane-Disruptive Mechanism.
AID1422366Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 33592 by microdilution assay2018European journal of medicinal chemistry, Sep-05, Volume: 157Broad-spectrum antibacterial amphiphilic aminoglycosides: A new focus on the structure of the lipophilic groups extends the series of active dialkyl neamines.
AID1616730Antibacterial activity against Escherichia coli assessed as reduction in bacterial growth incubated for 12 hrs by microdilution method
AID1318927Antibacterial activity against multidrug-resistant/tobramycin-susceptible Pseudomonas aeruginosa isolate 860532016Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
Hybrid Antibiotic Overcomes Resistance in P. aeruginosa by Enhancing Outer Membrane Penetration and Reducing Efflux.
AID1575410Antibacterial activity against Enterococcus faecium isolate 568 after 16 hrs by agar diffusion method2019Journal of natural products, 01-25, Volume: 82, Issue:1
Antibacterial Aromatic Polyketides Incorporating the Unusual Amino Acid Enduracididine.
AID1311807Antibacterial activity against Pseudomonas aeruginosa Boston 41501 ATCC 27853 by two fold serial dilution method2016Bioorganic & medicinal chemistry, 09-15, Volume: 24, Issue:18
Antibacterial and anticancer activity of a series of novel peptides incorporating cyclic tetra-substituted C(α) amino acids.
AID1435681Antibacterial activity against Klebsiella pneumoniae HK11750/08 after 24 hrs by broth microdilution method2017European journal of medicinal chemistry, Jan-27, Volume: 126S-substituted 3,5-dinitrophenyl 1,3,4-oxadiazole-2-thiols and tetrazole-5-thiols as highly efficient antitubercular agents.
AID1318901Antibacterial activity against multidrug-resistant/tobramycin-susceptible Pseudomonas aeruginosa isolate 860522016Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
Hybrid Antibiotic Overcomes Resistance in P. aeruginosa by Enhancing Outer Membrane Penetration and Reducing Efflux.
AID1884060Antibacterial activity against Staphylococcus aureus LMG 8224 incubated for 20 hrs by CLSI based broth microdilution method2022Journal of natural products, 06-24, Volume: 85, Issue:6
Chemically Tuning Resveratrol for the Effective Killing of Gram-Positive Pathogens.
AID1662707Ototoxicity against C57BL/6 mouse cochlea hair cells assessed as reduction in cell viability at 0.1 mM incubated for 23 hrs by FITC-phalloidin staining-based assay2020Bioorganic & medicinal chemistry letters, 07-01, Volume: 30, Issue:13
The relationship between the structure and toxicity of aminoglycoside antibiotics.
AID1627395Antibacterial activity against methicillin resistant Staphylococcus aureus clinical isolate 1 incubated for 7 to 14 days by microdilution resazurin assay2016Bioorganic & medicinal chemistry, 09-15, Volume: 24, Issue:18
Structure elucidation of anti-methicillin resistant Staphylococcus aureus (MRSA) flavonoids from balsam poplar buds.
AID1867042Antimicrobial activity against Pseudomonas aeruginosa PA14 assessed as reduction in bacterial growth and measured for 24 hrs by resazurin dye based broth microdilution method
AID1585553Antibacterial activity against Staphylococcus aureus ATCC 6538 after 24 hrs by broth dilution method2019European journal of medicinal chemistry, Jan-15, Volume: 162Benzofuran derivatives and their anti-tubercular, anti-bacterial activities.
AID1369438Bactericidal activity against Salmonella pullorum ATCC 79132018Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides.
AID1695827Antibacterial activity against Escherichia coli RCMB-010052 assessed as diameter of inhibition zone at 5 mg/ml by diffusion technique2019European journal of medicinal chemistry, Apr-15, Volume: 168Comprehensive review on the anti-bacterial activity of 1,2,3-triazole hybrids.
AID1878482Bactericidal activity against Enterococcus faecalis ATCC 29212 incubated for 90 mins by serial dilution assay2022European journal of medicinal chemistry, Mar-05, Volume: 231Systematic comparison of activity and mechanism of antimicrobial peptides against nosocomial pathogens.
AID1695926Antibacterial activity against Escherichia coli ATCC 25922 incubated for 24 hrs by broth dilution method2019European journal of medicinal chemistry, Apr-15, Volume: 168Comprehensive review on the anti-bacterial activity of 1,2,3-triazole hybrids.
AID1713884Antibacterial activity against methicillin-resistant Staphylococcus aureus CEMTC 1732 assessed as bacterial growth inhibition by CLSI protocol based serial microdilution method2016Bioorganic & medicinal chemistry, 11-15, Volume: 24, Issue:22
Biological evaluation of tetracationic compounds based on two 1,4-diazabicyclo[2.2.2]octane moieties connected by different linkers.
AID1416397Antibacterial activity against Klebsiella pneumoniae at 75 ug/ml incubated for 24 hrs by agar well diffusion method2017MedChemComm, Aug-01, Volume: 8, Issue:8
Synthesis and molecular docking studies of xanthone attached amino acids as potential antimicrobial and anti-inflammatory agents.
AID1570730Antimicrobial activity against Enterococcus faecalis ATCC 29212 at 30 ug/disk incubated for 20 +/- 4 hrs by agar disk diffusion method2019Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
Synthesis and evaluation of 1,3,4-oxadiazole derivatives for development as broad-spectrum antibiotics.
AID1540932Effect on growth of Enterobacter cloacae ATCC BAA 1143 assessed as bacterial growth inhibition measured after 16 to 18 hrs grown in tryptic soy medium by CLSI method
AID1776895Antibacterial activity against Escherichia coli MTCC442 at 5 ug/ml2021Bioorganic & medicinal chemistry letters, 07-15, Volume: 44Design, synthesis and antimicrobial activity of novel 2-aminothiophene containing cyclic and heterocyclic moieties.
AID1539467Antibacterial activity against Escherichia coli ATCC 1411 clinical isolates after 18 to 20 hrs in aerobic condition by CLSI-based broth microdilution assay
AID1393148Antimicrobial activity against Moraxella catarrhalis L3292 by broth microdilution method2017Journal of natural products, 04-28, Volume: 80, Issue:4
Antibacterial Paramagnetic Quinones from Actinoallomurus.
AID1462764Antimicrobial activity against Pseudomonas aeruginosa ATCC 27853 assessed as growth inhibition incubated overnight at 37degC by visual and photometry based method2017Bioorganic & medicinal chemistry, 10-15, Volume: 25, Issue:20
Methyl propiolate and 3-butynone: Starting points for synthesis of amphiphilic 1,2,3-triazole peptidomimetics for antimicrobial evaluation.
AID1265201Bactericidal activity against Proteus vulgaris ATCC 13315 after 24 hrs2015Bioorganic & medicinal chemistry letters, Dec-15, Volume: 25, Issue:24
Synthesis, biological activity evaluation and molecular docking studies of novel coumarin substituted thiazolyl-3-aryl-pyrazole-4-carbaldehydes.
AID1884054Antibacterial activity against Bacillus cereus ATCC 10987 incubated for 20 hrs by CLSI based broth microdilution method2022Journal of natural products, 06-24, Volume: 85, Issue:6
Chemically Tuning Resveratrol for the Effective Killing of Gram-Positive Pathogens.
AID1524039Antimicrobial activity against Pseudomonas aeruginosa CICC 21630 clinical isolates after 24 hrs by NCCLS-protocol based assay2019Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5
Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria.
AID1870153Antibacterial activity against wild type Staphylococcus aureus 4461/A assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay2022Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14
LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials.
AID1578420Antimicrobial activity against Escherichia coli BW25113 by broth liquid microdilution method2020European journal of medicinal chemistry, Jan-01, Volume: 185Modifying the lipophilic part of phenylthiazole antibiotics to control their drug-likeness.
AID1369475Antibacterial activity against Escherichia coli ATCC 25922 after 18 hrs in presence of ZnCl2 by broth dilution method2018Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides.
AID1393145Antimicrobial activity against delta-tolC containing Escherichia coli L4242 by broth microdilution method2017Journal of natural products, 04-28, Volume: 80, Issue:4
Antibacterial Paramagnetic Quinones from Actinoallomurus.
AID1578414Antimicrobial activity against methicillin-resistant Staphylococcus aureus NRS384 by broth liquid microdilution method2020European journal of medicinal chemistry, Jan-01, Volume: 185Modifying the lipophilic part of phenylthiazole antibiotics to control their drug-likeness.
AID1524034Antimicrobial activity against Escherichia coli 078 after 24 hrs by NCCLS-protocol based assay2019Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5
Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria.
AID1695826Antibacterial activity against Pseudomonas aeruginosa RCMB-010043 assessed as diameter of inhibition zone at 5 mg/ml by diffusion technique2019European journal of medicinal chemistry, Apr-15, Volume: 168Comprehensive review on the anti-bacterial activity of 1,2,3-triazole hybrids.
AID1713873Antibacterial activity against Proteus vulgaris ATCC 6380 assessed as concentration required to inhibit visible growth by CLSI protocol based serial microdilution method2016Bioorganic & medicinal chemistry, 11-15, Volume: 24, Issue:22
Biological evaluation of tetracationic compounds based on two 1,4-diazabicyclo[2.2.2]octane moieties connected by different linkers.
AID1329749Antibacterial activity against Escherichia coli ATCC 25922 after 24 hrs by broth microdilution method
AID1713886Antibacterial activity against methicillin-resistant Staphylococcus aureus CEMTC 1733 assessed as bacterial growth inhibition by CLSI protocol based serial microdilution method2016Bioorganic & medicinal chemistry, 11-15, Volume: 24, Issue:22
Biological evaluation of tetracationic compounds based on two 1,4-diazabicyclo[2.2.2]octane moieties connected by different linkers.
AID1577329Antimycobacterial activity against multi-drug resistant Mycobacterium tuberculosis Praha 4 after 14 days2019Journal of medicinal chemistry, 09-12, Volume: 62, Issue:17
Development of 3,5-Dinitrophenyl-Containing 1,2,4-Triazoles and Their Trifluoromethyl Analogues as Highly Efficient Antitubercular Agents Inhibiting Decaprenylphosphoryl-β-d-ribofuranose 2'-Oxidase.
AID1278331Antimicrobial activity against Pseudomonas aeruginosa PAO1 after 18 hrs by microdilution method in absence of iron2016European journal of medicinal chemistry, Mar-03, Volume: 110Design, synthesis and biological evaluation of monobactams as antibacterial agents against gram-negative bacteria.
AID1463956Antimycobacterial activity MDR/XDR against Mycobacterium tuberculosis isolate Praha 1 incubated for 14 days by micromethod2017Bioorganic & medicinal chemistry, 10-15, Volume: 25, Issue:20
Development of water-soluble 3,5-dinitrophenyl tetrazole and oxadiazole antitubercular agents.
AID1391499Antibacterial activity against Bacillus subtilis after 24 hrs by UV-vis spectrophotometric method
AID1265204Bactericidal activity against Bacillus cereus ATCC 14579 after 24 hrs2015Bioorganic & medicinal chemistry letters, Dec-15, Volume: 25, Issue:24
Synthesis, biological activity evaluation and molecular docking studies of novel coumarin substituted thiazolyl-3-aryl-pyrazole-4-carbaldehydes.
AID1278330Antimicrobial activity against Pseudomonas aeruginosa 27853 after 18 hrs by microdilution method in absence of iron2016European journal of medicinal chemistry, Mar-03, Volume: 110Design, synthesis and biological evaluation of monobactams as antibacterial agents against gram-negative bacteria.
AID1356829Antimicrobial activity against Klebsiella pneumoniae ATCC BAA-2472 by broth microdilution method2018Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
Total Synthesis and Structure-Activity Relationships Study of Odilorhabdins, a New Class of Peptides Showing Potent Antibacterial Activity.
AID1369427Antibacterial activity against Escherichia coli ATCC 25922 after 24 hrs2018Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides.
AID1356836Antimicrobial activity against Enterobacter cloacae ATCC BAA-2468 by broth microdilution method2018Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
Total Synthesis and Structure-Activity Relationships Study of Odilorhabdins, a New Class of Peptides Showing Potent Antibacterial Activity.
AID1393147Antimicrobial activity against Escherichia coli ATCC 25922 by broth microdilution method2017Journal of natural products, 04-28, Volume: 80, Issue:4
Antibacterial Paramagnetic Quinones from Actinoallomurus.
AID1318936Antibacterial activity against multidrug-resistant/tobramycin-susceptible Pseudomonas aeruginosa isolate 847452016Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
Hybrid Antibiotic Overcomes Resistance in P. aeruginosa by Enhancing Outer Membrane Penetration and Reducing Efflux.
AID1616729Antibacterial activity against methicillin resistant Staphylococcus aureus assessed as reduction in bacterial growth incubated for 12 hrs by microdilution method
AID1545131Antibacterial activity against Escherichia coli by CLSI protocol based method2019Journal of natural products, 08-23, Volume: 82, Issue:8
Antibacterial and Inhibitory Activities against Nitric Oxide Production of Coumaronochromones and Prenylated Isoflavones from
AID1884069Antimicrobial activity against Escherichia coli LMG 8224 incubated for 20 hrs by CLSI based broth microdilution method2022Journal of natural products, 06-24, Volume: 85, Issue:6
Chemically Tuning Resveratrol for the Effective Killing of Gram-Positive Pathogens.
AID1493078Antibacterial activity against vancomycin-resistant Enterococcus faecalis 12 by dilution susceptibility test2017Journal of natural products, 11-22, Volume: 80, Issue:11
Antibacterial 3,6-Disubstituted 4-Hydroxy-5,6-dihydro-2H-pyran-2-ones from Serratia plymuthica MF371-2.
AID1422374Antibacterial activity against Escherichia coli PAZ505H8101 harboring AAC6'-1B by microdilution assay2018European journal of medicinal chemistry, Sep-05, Volume: 157Broad-spectrum antibacterial amphiphilic aminoglycosides: A new focus on the structure of the lipophilic groups extends the series of active dialkyl neamines.
AID1318930Antibacterial activity against multidrug-resistant/tobramycin-susceptible Pseudomonas aeruginosa isolate 861412016Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
Hybrid Antibiotic Overcomes Resistance in P. aeruginosa by Enhancing Outer Membrane Penetration and Reducing Efflux.
AID1369484Antibacterial activity against Escherichia coli ATCC 25922 after 18 hrs in presence of 12.5% human heat-inactivated serum by broth dilution method2018Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides.
AID1318926Antibacterial activity against Pseudomonas aeruginosa PAO12016Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
Hybrid Antibiotic Overcomes Resistance in P. aeruginosa by Enhancing Outer Membrane Penetration and Reducing Efflux.
AID1539472Antibacterial activity against Salmonella enteritidis ATCC 13076 clinical isolates after 18 to 20 hrs in aerobic condition by CLSI-based broth microdilution assay
AID1322256Antibacterial activity against Escherichia coli ATCC 25922 by microdilution method2016Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20
New Broad-Spectrum Antibacterial Amphiphilic Aminoglycosides Active against Resistant Bacteria: From Neamine Derivatives to Smaller Neosamine Analogues.
AID1870130Antibacterial activity against antibiotic resistant Staphylococcus aureus 4679/B assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay2022Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14
LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials.
AID1430403Antibacterial activity against Escherichia coli ATCC 20732 after 24 to 48 hrs by macro-broth dilution method2017Bioorganic & medicinal chemistry letters, 03-01, Volume: 27, Issue:5
Methylsulfonyl benzothiazoles (MSBT) derivatives: Search for new potential antimicrobial and anticancer agents.
AID1321293Antimicrobial activity against Escherichia coli IFO 3301 measured after 24 hrs by microdilution method2016Bioorganic & medicinal chemistry letters, 10-01, Volume: 26, Issue:19
Synthesis, biological evaluation and molecular modeling study of some new methoxylated 2-benzylthio-quinazoline-4(3H)-ones as nonclassical antifolates.
AID1567127Antimicrobial activity against Streptococcus pyogenes ATCC 19615 incubated for 20 hrs by microdilution method2019European journal of medicinal chemistry, Sep-15, Volume: 178Design, synthesis and biological evaluation of antimicrobial diarylimine and -amine compounds targeting the interaction between the bacterial NusB and NusE proteins.
AID1539477Antibacterial activity against Pseudomonas aeruginosa ATCC 25619 clinical isolates after 18 to 20 hrs in aerobic condition by CLSI-based broth microdilution assay
AID1609311Bactericidal activity against Escherichia coli ATCC 259222019European journal of medicinal chemistry, Nov-15, Volume: 182Phenylthiazoles with nitrogenous side chain: An approach to overcome molecular obesity.
AID1870148Antibacterial activity against wild type Staphylococcus aureus 4566/A assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay2022Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14
LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials.
AID1524037Antimicrobial activity against Pseudomonas aeruginosa ATCC 27853 after 24 hrs by NCCLS-protocol based assay2019Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5
Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria.
AID1391497Antibacterial activity against Staphylococcus aureus assessed as diameter of inhibition zone measured after 24 hrs by agar well diffusion method
AID1278312Antimicrobial activity against Pseudomonas aeruginosa PAO1 after 18 hrs by microdilution method in presence of 4 uM iron2016European journal of medicinal chemistry, Mar-03, Volume: 110Design, synthesis and biological evaluation of monobactams as antibacterial agents against gram-negative bacteria.
AID1282522Cytotoxicity against HK2 cells assessed as GGT release by Western blot analysis2016Journal of medicinal chemistry, Feb-11, Volume: 59, Issue:3
Activity and Predicted Nephrotoxicity of Synthetic Antibiotics Based on Polymyxin B.
AID1516021Antibacterial activity against Salmonella enterica serovar typhimurium C77-31 incubated for 18 to 24 hrs by broth microdilution method2019Journal of medicinal chemistry, 08-08, Volume: 62, Issue:15
Design of Trp-Rich Dodecapeptides with Broad-Spectrum Antimicrobial Potency and Membrane-Disruptive Mechanism.
AID1575407Antibacterial activity against Streptococcus pyogenes isolate 49 after 16 hrs by agar diffusion method2019Journal of natural products, 01-25, Volume: 82, Issue:1
Antibacterial Aromatic Polyketides Incorporating the Unusual Amino Acid Enduracididine.
AID1809588Antibacterial activity against Staphylococcus aureus ATCC 25922 assessed as zone of inhibition at 5 mg/ml2021Bioorganic & medicinal chemistry letters, 11-15, Volume: 52Synthesis, anti-microbial, toxicity and molecular docking studies of N-nitroso-N-phenylhydroxylamine (cupferron) and its derivatives.
AID1516020Antibacterial activity against Staphylococcus aureus ATCC 29213 incubated for 18 to 24 hrs by broth microdilution method2019Journal of medicinal chemistry, 08-08, Volume: 62, Issue:15
Design of Trp-Rich Dodecapeptides with Broad-Spectrum Antimicrobial Potency and Membrane-Disruptive Mechanism.
AID1567134Antimicrobial activity against CA-methicillin-resistant Staphylococcus aureus W46 ST59 incubated for 20 hrs by microdilution method2019European journal of medicinal chemistry, Sep-15, Volume: 178Design, synthesis and biological evaluation of antimicrobial diarylimine and -amine compounds targeting the interaction between the bacterial NusB and NusE proteins.
AID1430434Antibacterial activity against Streptococcus agalactiae group B ATCC 12386 after overnight incubation by photometric method2017Bioorganic & medicinal chemistry letters, 03-01, Volume: 27, Issue:5
Synthesis and antimicrobial evaluation of cationic low molecular weight amphipathic 1,2,3-triazoles.
AID1778064Antibacterial activity against vancomycin-resistant Enterococcus faecalis ATCC 51299 assessed as inhibition of bacterial growth measured after 16 to 20 hrs by CLSI broth microdilution method
AID1884057Antibacterial activity against Enterococcus faecalis V583 incubated for 20 hrs by CLSI based broth microdilution method2022Journal of natural products, 06-24, Volume: 85, Issue:6
Chemically Tuning Resveratrol for the Effective Killing of Gram-Positive Pathogens.
AID1321217Antimicrobial activity against Pseudomonas aeruginosa IFO 3448 at 200 ug/disc measured after 24 hrs by agar disc-diffusion method2016Bioorganic & medicinal chemistry letters, 10-01, Volume: 26, Issue:19
Synthesis, biological evaluation and molecular modeling study of some new methoxylated 2-benzylthio-quinazoline-4(3H)-ones as nonclassical antifolates.
AID1627300Antibacterial activity against Staphylococcus aureus ATCC 29213 by broth microdilution method2016Bioorganic & medicinal chemistry letters, 08-15, Volume: 26, Issue:16
New antibacterial agents: Hybrid bioisoster derivatives as potential E. coli FabH inhibitors.
AID1824272Antimicrobial activity against Klebsiella pneumoniae clinical isolate T2301 expressing NDM-1 assessed as inhibition of bacterial growth by CLSI protocol based broth microdilution assay2022European journal of medicinal chemistry, Jan-15, Volume: 228Nitroxoline and its derivatives are potent inhibitors of metallo-β-lactamases.
AID1511408Antibacterial activity against Ralstonia solanacearum assessed as reduction in bacterial cell growth incubated for 24 hrs by filter paper assay2019Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
Synthesis and biological evaluation of calycanthaceous alkaloid analogs.
AID1878479Bactericidal activity against Salmonella enterica serovar typhimurium SL1344 incubated for 90 mins by serial dilution assay2022European journal of medicinal chemistry, Mar-05, Volume: 231Systematic comparison of activity and mechanism of antimicrobial peptides against nosocomial pathogens.
AID1653073Antibacterial activity against Escherichia coli assessed as zone of inhibition at 100 ug/ml2019European journal of medicinal chemistry, Feb-15, Volume: 164Isatin derivatives and their anti-bacterial activities.
AID1627403Antibacterial activity against methicillin resistant Staphylococcus aureus clinical isolate 9 incubated for 7 to 14 days by microdilution resazurin assay2016Bioorganic & medicinal chemistry, 09-15, Volume: 24, Issue:18
Structure elucidation of anti-methicillin resistant Staphylococcus aureus (MRSA) flavonoids from balsam poplar buds.
AID1444334Antibacterial activity against Pseudomonas aeruginosa ATCC 9027 after 24 hrs by broth microdilution method2017European journal of medicinal chemistry, Apr-21, Volume: 130Structure-activity relationship studies on 3,5-dinitrophenyl tetrazoles as antitubercular agents.
AID1730947Antibacterial activity against Pseudomonas aeruginosa MTCC 1688 assessed as bacterial growth inhibition2021Bioorganic & medicinal chemistry letters, 03-15, Volume: 36Structure based design, synthesis, and biological evaluation of imidazole derivatives targeting dihydropteroate synthase enzyme.
AID1609306Antibacterial activity against Pseudomonas aeruginosa ATCC 278532019European journal of medicinal chemistry, Nov-15, Volume: 182Phenylthiazoles with nitrogenous side chain: An approach to overcome molecular obesity.
AID1430045Antibacterial activity against Staphylococcus aureus ATCC 25923 by broth microdilution method
AID1567139Antimicrobial activity against Staphylococcus aureus HA W235 ST5 incubated for 20 hrs by microdilution method2019European journal of medicinal chemistry, Sep-15, Volume: 178Design, synthesis and biological evaluation of antimicrobial diarylimine and -amine compounds targeting the interaction between the bacterial NusB and NusE proteins.
AID1575401Antibacterial activity against Staphylococcus aureus ATCC 29213 after 16 hrs by agar diffusion method2019Journal of natural products, 01-25, Volume: 82, Issue:1
Antibacterial Aromatic Polyketides Incorporating the Unusual Amino Acid Enduracididine.
AID1677471Antibacterial activity against Micrococcus luteus2020Bioorganic & medicinal chemistry letters, 11-01, Volume: 30, Issue:21
New antibacterial cadiolide analogues active against antibiotic-resistant strains.
AID1625356Antibacterial activity against Staphylococcus aureus DSM 799 incubated for 24 hrs by disk diffusion method2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Antibacterial Azaphilones from an Endophytic Fungus, Colletotrichum sp. BS4.
AID1713864Antibacterial activity against Enterococcus faecalis ATCC 51299 assessed as bacterial growth inhibition by CLSI protocol based serial microdilution method2016Bioorganic & medicinal chemistry, 11-15, Volume: 24, Issue:22
Biological evaluation of tetracationic compounds based on two 1,4-diazabicyclo[2.2.2]octane moieties connected by different linkers.
AID1265193Antibacterial activity against Escherichia coli ATCC 8739 after 24 hrs by microtiter plate method2015Bioorganic & medicinal chemistry letters, Dec-15, Volume: 25, Issue:24
Synthesis, biological activity evaluation and molecular docking studies of novel coumarin substituted thiazolyl-3-aryl-pyrazole-4-carbaldehydes.
AID1356831Antimicrobial activity against Klebsiella pneumoniae NCTC 13443 by broth microdilution method2018Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
Total Synthesis and Structure-Activity Relationships Study of Odilorhabdins, a New Class of Peptides Showing Potent Antibacterial Activity.
AID1676979Antimicrobial activity against vancomycin-resistant Enterococcus faecium ATCC 700221 assessed as reduction in microbial growth after 48 hrs by CLSI based broth microdilution method
AID1318931Antibacterial activity against multidrug-resistant/tobramycin-susceptible Pseudomonas aeruginosa isolate 920142016Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
Hybrid Antibiotic Overcomes Resistance in P. aeruginosa by Enhancing Outer Membrane Penetration and Reducing Efflux.
AID1809592Antibacterial activity against Streptococcus pyogenes ATCC 19615 assessed as zone of inhibition at 10 mg/ml2021Bioorganic & medicinal chemistry letters, 11-15, Volume: 52Synthesis, anti-microbial, toxicity and molecular docking studies of N-nitroso-N-phenylhydroxylamine (cupferron) and its derivatives.
AID1497852Antibacterial activity against Staphylococcus epidermidis ATCC 12228 assessed as diameter of inhibition zone at 200 ug per disc after 24 hrs by agar disc diffusion method2018Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12
Design, synthesis and biological evaluation of benzofuran appended benzothiazepine derivatives as inhibitors of butyrylcholinesterase and antimicrobial agents.
AID1318924Antibacterial activity against pandrug-resistant Pseudomonas aeruginosa isolate 914332016Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
Hybrid Antibiotic Overcomes Resistance in P. aeruginosa by Enhancing Outer Membrane Penetration and Reducing Efflux.
AID1567115Antimicrobial activity against Staphylococcus aureus ATCC 25923 incubated for 20 hrs by microdilution method2019European journal of medicinal chemistry, Sep-15, Volume: 178Design, synthesis and biological evaluation of antimicrobial diarylimine and -amine compounds targeting the interaction between the bacterial NusB and NusE proteins.
AID1539474Antibacterial activity against Salmonella typhimurium ATCC 700720 after 18 to 20 hrs in aerobic condition by CLSI-based broth microdilution assay
AID1463960Antimycobacterial activity MDR/XDR against Mycobacterium tuberculosis isolate 234/2005 incubated for 14 days by micromethod2017Bioorganic & medicinal chemistry, 10-15, Volume: 25, Issue:20
Development of water-soluble 3,5-dinitrophenyl tetrazole and oxadiazole antitubercular agents.
AID1497856Antibacterial activity against Salmonella paratyphi A serotype ATCC 5702 assessed as diameter of inhibition zone at 200 ug per disc after 24 hrs by agar disc diffusion method2018Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12
Design, synthesis and biological evaluation of benzofuran appended benzothiazepine derivatives as inhibitors of butyrylcholinesterase and antimicrobial agents.
AID1567125Antimicrobial activity against Staphylococcus epidermidis ATCC 12228 incubated for 20 hrs by microdilution method2019European journal of medicinal chemistry, Sep-15, Volume: 178Design, synthesis and biological evaluation of antimicrobial diarylimine and -amine compounds targeting the interaction between the bacterial NusB and NusE proteins.
AID1272236Antibacterial activity against Pseudomonas aeruginosa by broth micro-dilution method2016Bioorganic & medicinal chemistry letters, Feb-01, Volume: 26, Issue:3
Efficiently functionalized oxacalix[4]arenes: Synthesis, characterization and exploration of their biological profile as novel HDAC inhibitors.
AID1265778Antibacterial activity against Bacillus subtilis assessed as growth inhibition incubated for 24 hrs at 37 degC by agar well diffusion method2016Bioorganic & medicinal chemistry letters, Jan-01, Volume: 26, Issue:1
An efficient green synthesis of 2-arylbenzothiazole analogues as potent antibacterial and anticancer agents.
AID1567121Antimicrobial activity against Acinetobacter baumannii ATCC 19606 incubated for 20 hrs by microdilution method2019European journal of medicinal chemistry, Sep-15, Volume: 178Design, synthesis and biological evaluation of antimicrobial diarylimine and -amine compounds targeting the interaction between the bacterial NusB and NusE proteins.
AID1809828Hemolytic activity in human RBC measured after 40 mins2021Journal of medicinal chemistry, 10-28, Volume: 64, Issue:20
Tandem Repeat of a Short Human Chemerin-Derived Peptide and Its Nontoxic d-Lysine-Containing Enantiomer Display Broad-Spectrum Antimicrobial and Antitubercular Activities.
AID1323752Antibacterial activity against Enterococcus faecalis ATCC 29212 after 16 to 20 hrs by broth microdilution method2016Bioorganic & medicinal chemistry, 11-01, Volume: 24, Issue:21
Investigation of C-5 alkynyl (alkynyloxy or hydroxymethyl) and/or N-3 propynyl substituted pyrimidine nucleoside analogs as a new class of antimicrobial agents.
AID1356828Antimicrobial activity against Klebsiella pneumoniae ATCC BAA-2146 by broth microdilution method2018Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
Total Synthesis and Structure-Activity Relationships Study of Odilorhabdins, a New Class of Peptides Showing Potent Antibacterial Activity.
AID1278310Antimicrobial activity against Pseudomonas aeruginosa PAO1 after 18 hrs by microdilution method in presence of 0.4 uM iron2016European journal of medicinal chemistry, Mar-03, Volume: 110Design, synthesis and biological evaluation of monobactams as antibacterial agents against gram-negative bacteria.
AID1575402Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate 3864 after 16 hrs by agar diffusion method2019Journal of natural products, 01-25, Volume: 82, Issue:1
Antibacterial Aromatic Polyketides Incorporating the Unusual Amino Acid Enduracididine.
AID1627301Antifungal activity against Candida albicans ATCC 10231 by broth dilution method2016Bioorganic & medicinal chemistry letters, 08-15, Volume: 26, Issue:16
New antibacterial agents: Hybrid bioisoster derivatives as potential E. coli FabH inhibitors.
AID1272235Antibacterial activity against Escherichia coli by broth micro-dilution method2016Bioorganic & medicinal chemistry letters, Feb-01, Volume: 26, Issue:3
Efficiently functionalized oxacalix[4]arenes: Synthesis, characterization and exploration of their biological profile as novel HDAC inhibitors.
AID1416414Antibacterial activity against Klebsiella pneumoniae incubated for 24 hrs by microdilution method2017MedChemComm, Aug-01, Volume: 8, Issue:8
Synthesis and molecular docking studies of xanthone attached amino acids as potential antimicrobial and anti-inflammatory agents.
AID1567128Antimicrobial activity against Streptococcus agalactiae ATCC 12386 incubated for 20 hrs by microdilution method2019European journal of medicinal chemistry, Sep-15, Volume: 178Design, synthesis and biological evaluation of antimicrobial diarylimine and -amine compounds targeting the interaction between the bacterial NusB and NusE proteins.
AID1870146Antibacterial activity against wild type Staphylococcus aureus 4460/A assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay2022Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14
LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials.
AID1870151Antibacterial activity against wild type Staphylococcus aureus 4717/B assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay2022Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14
LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials.
AID1591939Antibacterial activity against Shigella flexneri by CLSI guideline based broth microdilution method2019Journal of natural products, 08-23, Volume: 82, Issue:8
Mallopenins A-E, Antibacterial Phenolic Derivatives from the Fruits of
AID1809589Antibacterial activity against Staphylococcus aureus ATCC 25922 assessed as zone of inhibition at 10 mg/ml2021Bioorganic & medicinal chemistry letters, 11-15, Volume: 52Synthesis, anti-microbial, toxicity and molecular docking studies of N-nitroso-N-phenylhydroxylamine (cupferron) and its derivatives.
AID1524043Antimicrobial activity against Salmonella typhimurium ATCC 14028 after 24 hrs by NCCLS-protocol based assay2019Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5
Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria.
AID1769951Antibacterial activity against methicillin resistant Staphylococcus aureus ATCC 43300 assessed as reduction in microbial growth after 16 to 18 hrs by microbroth dilution method2021European journal of medicinal chemistry, Nov-15, Volume: 224Synthetic cajaninstilbene acid derivatives eradicate methicillin-resistant Staphylococcus aureus persisters and biofilms.
AID1497861Antibacterial activity against Proteus vulgaris PTCC 1182 assessed as diameter of inhibition zone at 200 ug per disc after 24 hrs by agar disc diffusion method2018Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12
Design, synthesis and biological evaluation of benzofuran appended benzothiazepine derivatives as inhibitors of butyrylcholinesterase and antimicrobial agents.
AID1567119Antimicrobial activity against Staphylococcus aureus ATCC 29213 incubated for 20 hrs by microdilution method2019European journal of medicinal chemistry, Sep-15, Volume: 178Design, synthesis and biological evaluation of antimicrobial diarylimine and -amine compounds targeting the interaction between the bacterial NusB and NusE proteins.
AID1545126Antibacterial activity against Staphylococcus epidermidis by CLSI protocol based method2019Journal of natural products, 08-23, Volume: 82, Issue:8
Antibacterial and Inhibitory Activities against Nitric Oxide Production of Coumaronochromones and Prenylated Isoflavones from
AID1416394Antibacterial activity against Escherichia coli at 100 ug/ml incubated for 24 hrs by agar well diffusion method2017MedChemComm, Aug-01, Volume: 8, Issue:8
Synthesis and molecular docking studies of xanthone attached amino acids as potential antimicrobial and anti-inflammatory agents.
AID1577335Antimycobacterial activity against multi-drug resistant Mycobacterium tuberculosis 234/2005 after 14 days2019Journal of medicinal chemistry, 09-12, Volume: 62, Issue:17
Development of 3,5-Dinitrophenyl-Containing 1,2,4-Triazoles and Their Trifluoromethyl Analogues as Highly Efficient Antitubercular Agents Inhibiting Decaprenylphosphoryl-β-d-ribofuranose 2'-Oxidase.
AID1463957Antimycobacterial activity MDR/XDR against Mycobacterium tuberculosis isolate Praha 4 incubated for 14 days by micromethod2017Bioorganic & medicinal chemistry, 10-15, Volume: 25, Issue:20
Development of water-soluble 3,5-dinitrophenyl tetrazole and oxadiazole antitubercular agents.
AID1497865Antibacterial activity against Klebsiella pneumoniae ATCC 100312018Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12
Design, synthesis and biological evaluation of benzofuran appended benzothiazepine derivatives as inhibitors of butyrylcholinesterase and antimicrobial agents.
AID1698476Antimicrobial activity against Escherichia coli ATCC 25922 assessed as reduction in microbial growth after 24 hrs by microdilution method2020Journal of natural products, 10-23, Volume: 83, Issue:10
Paecilosetin Derivatives as Potent Antimicrobial Agents from
AID1677468Antibacterial activity against Staphylococcus aureus EMRSA172020Bioorganic & medicinal chemistry letters, 11-01, Volume: 30, Issue:21
New antibacterial cadiolide analogues active against antibiotic-resistant strains.
AID1318922Antibacterial activity against multidrug/extremely drug-resistant/colistin-susceptible Pseudomonas aeruginosa isolate 262-1018562016Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
Hybrid Antibiotic Overcomes Resistance in P. aeruginosa by Enhancing Outer Membrane Penetration and Reducing Efflux.
AID1430050Antibacterial activity against Klebsiella pneumoniae ATCC 27736 by broth microdilution method
AID1870131Antibacterial activity against antibiotic resistant Staphylococcus aureus 4502/A assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay2022Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14
LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials.
AID1878480Bactericidal activity against Staphylococcus aureus ATCC 29213 incubated for 90 mins by serial dilution assay2022European journal of medicinal chemistry, Mar-05, Volume: 231Systematic comparison of activity and mechanism of antimicrobial peptides against nosocomial pathogens.
AID1311806Antibacterial activity against Salmonella enterica LT2 Typhimurium ATCC 15277 by two fold serial dilution method2016Bioorganic & medicinal chemistry, 09-15, Volume: 24, Issue:18
Antibacterial and anticancer activity of a series of novel peptides incorporating cyclic tetra-substituted C(α) amino acids.
AID1511406Antibacterial activity against Escherichia coli assessed as reduction in bacterial cell growth incubated for 24 hrs by filter paper assay2019Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
Synthesis and biological evaluation of calycanthaceous alkaloid analogs.
AID1318921Antibacterial activity against multidrug/extremely drug-resistant/colistin-susceptible Pseudomonas aeruginosa isolate 260-971032016Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
Hybrid Antibiotic Overcomes Resistance in P. aeruginosa by Enhancing Outer Membrane Penetration and Reducing Efflux.
AID1497858Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 assessed as diameter of inhibition zone at 200 ug per disc after 24 hrs by agar disc diffusion method2018Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12
Design, synthesis and biological evaluation of benzofuran appended benzothiazepine derivatives as inhibitors of butyrylcholinesterase and antimicrobial agents.
AID1318928Antibacterial activity against multidrug-resistant/tobramycin-susceptible Pseudomonas aeruginosa isolate 860672016Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
Hybrid Antibiotic Overcomes Resistance in P. aeruginosa by Enhancing Outer Membrane Penetration and Reducing Efflux.
AID1271794Antibacterial activity against Staphylococcus aureus ATCC 25923 after 24 hrs by broth microdilution method2016Bioorganic & medicinal chemistry letters, Jan-15, Volume: 26, Issue:2
Synthesis, antibacterial and cytotoxic activities of new biflorin-based hydrazones and oximes.
AID1416395Antibacterial activity against Klebsiella pneumoniae at 25 ug/ml incubated for 24 hrs by agar well diffusion method2017MedChemComm, Aug-01, Volume: 8, Issue:8
Synthesis and molecular docking studies of xanthone attached amino acids as potential antimicrobial and anti-inflammatory agents.
AID1278337Antimicrobial activity against Pseudomonas aeruginosa 27853 after 18 hrs by microdilution method in presence of 40 uM iron2016European journal of medicinal chemistry, Mar-03, Volume: 110Design, synthesis and biological evaluation of monobactams as antibacterial agents against gram-negative bacteria.
AID1462760Antimicrobial activity against Enterococcus faecalis ATCC 29212 assessed as growth inhibition incubated overnight at 37degC by visual and photometry based method2017Bioorganic & medicinal chemistry, 10-15, Volume: 25, Issue:20
Methyl propiolate and 3-butynone: Starting points for synthesis of amphiphilic 1,2,3-triazole peptidomimetics for antimicrobial evaluation.
AID1442089Antibacterial activity against Pseudomonas aeruginosa CICC 21630 after 18 hrs by broth microdilution method2017Journal of medicinal chemistry, 03-23, Volume: 60, Issue:6
Novel Design of Heptad Amphiphiles To Enhance Cell Selectivity, Salt Resistance, Antibiofilm Properties and Their Membrane-Disruptive Mechanism.
AID1360040Antimicrobial activity against Escherichia coli after 18 to 20 hrs by micro broth dilution method2018European journal of medicinal chemistry, Jun-25, Volume: 154Free radical rearrangement synthesis and microbiological evaluation of novel 2-sulfoether-4-quinolone scaffolds as potential antibacterial agents.
AID1616731Antifungal activity against Candida albicans assessed as reduction in fungal growth incubated for 12 hrs by microdilution method
AID1713883Antibacterial activity against methicillin-resistant Staphylococcus aureus CEMTC 1732 assessed as concentration required to inhibit visible growth by CLSI protocol based serial microdilution method2016Bioorganic & medicinal chemistry, 11-15, Volume: 24, Issue:22
Biological evaluation of tetracationic compounds based on two 1,4-diazabicyclo[2.2.2]octane moieties connected by different linkers.
AID1369441Bactericidal activity against Staphylococcus epidermidis ATCC 122282018Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides.
AID1501225Antibacterial activity against Escherichia coli ATCC 25922 measured after 18 hrs by dilution susceptibility test2017Journal of natural products, 09-22, Volume: 80, Issue:9
Thalassosamide, a Siderophore Discovered from the Marine-Derived Bacterium Thalassospira profundimaris.
AID1516086Resistance index, ratio of MIC for antibacterial activity against ciprofloxacin-resistant Escherichia coli to MIC for Escherichia coli ATCC 25922 incubated for 18 to 24 hrs by broth microdilution method2019Journal of medicinal chemistry, 08-08, Volume: 62, Issue:15
Design of Trp-Rich Dodecapeptides with Broad-Spectrum Antimicrobial Potency and Membrane-Disruptive Mechanism.
AID1524126Bactericidal activity against Pseudomonas aeruginosa ATCC 27853 incubated for 4 hrs followed by culture spread on agar plates and cultured overnight2019Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5
Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria.
AID1369439Bactericidal activity against Staphylococcus aureus ATCC 292132018Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides.
AID1616908Antibacterial activity against Pseudomonas aeruginosa DSM PA14 incubated for 24 hrs by broth microdilution method
AID1567126Antimicrobial activity against Staphylococcus saprophyticus ATCC 15305 incubated for 20 hrs by microdilution method2019European journal of medicinal chemistry, Sep-15, Volume: 178Design, synthesis and biological evaluation of antimicrobial diarylimine and -amine compounds targeting the interaction between the bacterial NusB and NusE proteins.
AID1369432Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 4330 after 24 hrs2018Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides.
AID1577327Antimycobacterial activity against multi-drug resistant Mycobacterium tuberculosis Praha 1 after 14 days2019Journal of medicinal chemistry, 09-12, Volume: 62, Issue:17
Development of 3,5-Dinitrophenyl-Containing 1,2,4-Triazoles and Their Trifluoromethyl Analogues as Highly Efficient Antitubercular Agents Inhibiting Decaprenylphosphoryl-β-d-ribofuranose 2'-Oxidase.
AID1516085Antibacterial activity against ciprofloxacin-resistant Escherichia coli ATCC 25922 incubated for 18 to 24 hrs2019Journal of medicinal chemistry, 08-08, Volume: 62, Issue:15
Design of Trp-Rich Dodecapeptides with Broad-Spectrum Antimicrobial Potency and Membrane-Disruptive Mechanism.
AID1278336Antimicrobial activity against Pseudomonas aeruginosa 27853 after 18 hrs by microdilution method in presence of 0.4 uM iron2016European journal of medicinal chemistry, Mar-03, Volume: 110Design, synthesis and biological evaluation of monobactams as antibacterial agents against gram-negative bacteria.
AID1369428Antibacterial activity against Escherichia coli 1005 after 24 hrs2018Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides.
AID1609314Bactericidal activity against Pseudomonas aeruginosa ATCC 154422019European journal of medicinal chemistry, Nov-15, Volume: 182Phenylthiazoles with nitrogenous side chain: An approach to overcome molecular obesity.
AID1609303Antibacterial activity against TolC-deficient Escherichia coli JW550312019European journal of medicinal chemistry, Nov-15, Volume: 182Phenylthiazoles with nitrogenous side chain: An approach to overcome molecular obesity.
AID1524127Bactericidal activity against Pseudomonas aeruginosa PAO1 incubated for 4 hrs followed by culture spread on agar plates and cultured overnight2019Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5
Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria.
AID1809815Antimicrobial activity against Escherichia coli ATCC 25922 assessed as inhibition of bacterial growth by broth dilution method2021Journal of medicinal chemistry, 10-28, Volume: 64, Issue:20
Tandem Repeat of a Short Human Chemerin-Derived Peptide and Its Nontoxic d-Lysine-Containing Enantiomer Display Broad-Spectrum Antimicrobial and Antitubercular Activities.
AID1809605Antibacterial activity against Salmonella typhi ATCC 6539 assessed as zone of inhibition at 15 mg/kg2021Bioorganic & medicinal chemistry letters, 11-15, Volume: 52Synthesis, anti-microbial, toxicity and molecular docking studies of N-nitroso-N-phenylhydroxylamine (cupferron) and its derivatives.
AID1884062Antibacterial activity against Staphylococcus aureus LMG 15975 incubated for 20 hrs by CLSI based broth microdilution method2022Journal of natural products, 06-24, Volume: 85, Issue:6
Chemically Tuning Resveratrol for the Effective Killing of Gram-Positive Pathogens.
AID1369435Bactericidal activity against Escherichia coli ATCC 259222018Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides.
AID1570736Antimicrobial activity against Enterococcus faecium AUS0004 at 30 ug/disk incubated for 20 +/- 4 hrs by agar disk diffusion method2019Bioorganic & medicinal chemistry, 11-01, Volume: 27, Issue:21
Synthesis and evaluation of 1,3,4-oxadiazole derivatives for development as broad-spectrum antibiotics.
AID1878478Bactericidal activity against Escherichia coli BAA3051 incubated for 90 mins by serial dilution assay2022European journal of medicinal chemistry, Mar-05, Volume: 231Systematic comparison of activity and mechanism of antimicrobial peptides against nosocomial pathogens.
AID1422372Antibacterial activity against Acinetobacter lwoffii AI.88-483 harboring APH3'-6A by microdilution assay2018European journal of medicinal chemistry, Sep-05, Volume: 157Broad-spectrum antibacterial amphiphilic aminoglycosides: A new focus on the structure of the lipophilic groups extends the series of active dialkyl neamines.
AID1442088Antibacterial activity against Pseudomonas aeruginosa CICC 21625 after 18 hrs by broth microdilution method2017Journal of medicinal chemistry, 03-23, Volume: 60, Issue:6
Novel Design of Heptad Amphiphiles To Enhance Cell Selectivity, Salt Resistance, Antibiofilm Properties and Their Membrane-Disruptive Mechanism.
AID1356833Antimicrobial activity against Escherichia coli ATCC BAA-2340 by broth microdilution method2018Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
Total Synthesis and Structure-Activity Relationships Study of Odilorhabdins, a New Class of Peptides Showing Potent Antibacterial Activity.
AID1271953Antibacterial activity against Pseudomonas aeruginosa assessed as growth inhibition at 10 mg/ml by drug sensitive assay2016Bioorganic & medicinal chemistry letters, Jan-15, Volume: 26, Issue:2
Novel skeleton compound Allomyrinanoid A and two purine alkaloids from the adult of Allomyrina dichotoma L.
AID1884058Antibacterial activity against Enterococcus faecalis LMG 11423 incubated for 20 hrs by CLSI based broth microdilution method2022Journal of natural products, 06-24, Volume: 85, Issue:6
Chemically Tuning Resveratrol for the Effective Killing of Gram-Positive Pathogens.
AID1394756Antimicrobial activity against Staphylococcus aureus AS 1.72 assessed as induction of outer membrane permeabilization by measuring NPN uptake up to 50 uM by fluorescence assay2018European journal of medicinal chemistry, Apr-25, Volume: 150Antimicrobial activity and self-assembly behavior of antimicrobial peptide chensinin-1b with lipophilic alkyl tails.
AID1653587Anti-leprotic activity against Mycobacterium leprae infected in BALB/c weanling mouse assessed as bacteria killing at 20 mg/kg, ip administrated for 60 days and measured after 1 year by Spearman-Karber technique analysis relative to control2019Bioorganic & medicinal chemistry, 07-01, Volume: 27, Issue:13
Insights of synthetic analogues of anti-leprosy agents.
AID1369476Antibacterial activity against Escherichia coli ATCC 25922 after 18 hrs in presence of FeCl3 by broth dilution method2018Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides.
AID1369429Antibacterial activity against Salmonella typhimurium ATCC 14028 after 24 hrs2018Journal of medicinal chemistry, 05-10, Volume: 61, Issue:9
Combating Drug-Resistant Fungi with Novel Imperfectly Amphipathic Palindromic Peptides.
AID1318929Antibacterial activity against multidrug-resistant/tobramycin-susceptible Pseudomonas aeruginosa isolate 860792016Journal of medicinal chemistry, 09-22, Volume: 59, Issue:18
Hybrid Antibiotic Overcomes Resistance in P. aeruginosa by Enhancing Outer Membrane Penetration and Reducing Efflux.
AID1416398Antibacterial activity against Klebsiella pneumoniae at 100 ug/ml incubated for 24 hrs by agar well diffusion method2017MedChemComm, Aug-01, Volume: 8, Issue:8
Synthesis and molecular docking studies of xanthone attached amino acids as potential antimicrobial and anti-inflammatory agents.
AID1809601Antibacterial activity against Escherichia coli ATCC 25922 assessed as zone of inhibition at 10 mg/ml2021Bioorganic & medicinal chemistry letters, 11-15, Volume: 52Synthesis, anti-microbial, toxicity and molecular docking studies of N-nitroso-N-phenylhydroxylamine (cupferron) and its derivatives.
AID1870143Antibacterial activity against wild type Staphylococcus aureus 4862/C assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay2022Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14
LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials.
AID1575406Antibacterial activity against Staphylococcus intermedius ATCC 29663 after 16 hrs by agar diffusion method2019Journal of natural products, 01-25, Volume: 82, Issue:1
Antibacterial Aromatic Polyketides Incorporating the Unusual Amino Acid Enduracididine.
AID1591936Antibacterial activity against Salmonella typhimurium by CLSI guideline based broth microdilution method2019Journal of natural products, 08-23, Volume: 82, Issue:8
Mallopenins A-E, Antibacterial Phenolic Derivatives from the Fruits of
AID1575408Antibacterial activity against Streptococcus pneumoniae ATCC BAA1407 after 16 hrs by agar diffusion method2019Journal of natural products, 01-25, Volume: 82, Issue:1
Antibacterial Aromatic Polyketides Incorporating the Unusual Amino Acid Enduracididine.
AID1524129Bactericidal activity against Pseudomonas aeruginosa 26305 clinical isolates incubated for 4 hrs followed by culture spread on agar plates and cultured overnight2019Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5
Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria.
AID1878481Bactericidal activity against Methicillin resistant Staphylococcus aureus ATCC 33591 incubated for 90 mins by serial dilution assay2022European journal of medicinal chemistry, Mar-05, Volume: 231Systematic comparison of activity and mechanism of antimicrobial peptides against nosocomial pathogens.
AID1322260Cytotoxicity against mouse J774 cells assessed as cell viability at 10 uM after 24 hrs by MTT assay relative to control2016Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20
New Broad-Spectrum Antibacterial Amphiphilic Aminoglycosides Active against Resistant Bacteria: From Neamine Derivatives to Smaller Neosamine Analogues.
AID1311804Antibacterial activity against carbapenem-resistant Enterobacter aerogenes NCDC819-56 ATCC 13048 by two fold serial dilution method2016Bioorganic & medicinal chemistry, 09-15, Volume: 24, Issue:18
Antibacterial and anticancer activity of a series of novel peptides incorporating cyclic tetra-substituted C(α) amino acids.
AID1609308Bactericidal activity against Acinetobacter baumannii ATCC 196062019European journal of medicinal chemistry, Nov-15, Volume: 182Phenylthiazoles with nitrogenous side chain: An approach to overcome molecular obesity.
AID1524044Antimicrobial activity against Salmonella typhimurium C7731 after 24 hrs by NCCLS-protocol based assay2019Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5
Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria.
AID1539466Antibacterial activity against Escherichia coli ATCC 35150 clinical isolates after 18 to 20 hrs in aerobic condition by CLSI-based broth microdilution assay
AID1416387Antibacterial activity against Bacillus subtilis at 25 ug/ml incubated for 24 hrs by agar well diffusion method2017MedChemComm, Aug-01, Volume: 8, Issue:8
Synthesis and molecular docking studies of xanthone attached amino acids as potential antimicrobial and anti-inflammatory agents.
AID1809817Antimicrobial activity against Klebsiella pneumoniae ATCC 27736 assessed as inhibition of bacterial growth by broth dilution method2021Journal of medicinal chemistry, 10-28, Volume: 64, Issue:20
Tandem Repeat of a Short Human Chemerin-Derived Peptide and Its Nontoxic d-Lysine-Containing Enantiomer Display Broad-Spectrum Antimicrobial and Antitubercular Activities.
AID1422367Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 by microdilution assay2018European journal of medicinal chemistry, Sep-05, Volume: 157Broad-spectrum antibacterial amphiphilic aminoglycosides: A new focus on the structure of the lipophilic groups extends the series of active dialkyl neamines.
AID1809581Antibacterial activity against Staphylococcus aureus ATCC 25922 assessed as bacterial growth inhibition2021Bioorganic & medicinal chemistry letters, 11-15, Volume: 52Synthesis, anti-microbial, toxicity and molecular docking studies of N-nitroso-N-phenylhydroxylamine (cupferron) and its derivatives.
AID1539460Antibacterial activity against Acinetobacter baumannii ATCC BAA 1141 clinical isolates after 18 to 20 hrs in aerobic condition by CLSI-based broth microdilution assay
AID1428626Antibacterial activity against methicillin-resistant Staphylococcus aureus USA300 by broth microdilution method2017European journal of medicinal chemistry, Feb-15, Volume: 127Diaryltriazenes as antibacterial agents against methicillin resistant Staphylococcus aureus (MRSA) and Mycobacterium smegmatis.
AID1360042Bactericidal activity against Staphylococcus aureus after 24 hrs by micro broth dilution method2018European journal of medicinal chemistry, Jun-25, Volume: 154Free radical rearrangement synthesis and microbiological evaluation of novel 2-sulfoether-4-quinolone scaffolds as potential antibacterial agents.
AID1809590Antibacterial activity against Staphylococcus aureus ATCC 25922 assessed as zone of inhibition at 15 mg/ml2021Bioorganic & medicinal chemistry letters, 11-15, Volume: 52Synthesis, anti-microbial, toxicity and molecular docking studies of N-nitroso-N-phenylhydroxylamine (cupferron) and its derivatives.
AID1627402Antibacterial activity against methicillin resistant Staphylococcus aureus clinical isolate 8 incubated for 7 to 14 days by microdilution resazurin assay2016Bioorganic & medicinal chemistry, 09-15, Volume: 24, Issue:18
Structure elucidation of anti-methicillin resistant Staphylococcus aureus (MRSA) flavonoids from balsam poplar buds.
AID1524038Antimicrobial activity against Pseudomonas aeruginosa PAO1 after 24 hrs by NCCLS-protocol based assay2019Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5
Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria.
AID1585529Antibacterial activity against Staphylococcus aureus ATCC 29213 after 24 hrs by broth dilution method2019European journal of medicinal chemistry, Jan-15, Volume: 162Benzofuran derivatives and their anti-tubercular, anti-bacterial activities.
AID1497851Antibacterial activity against Bacillus subtilis ATCC 6633 assessed as diameter of inhibition zone at 200 ug per disc after 24 hrs by agar disc diffusion method2018Bioorganic & medicinal chemistry, 07-23, Volume: 26, Issue:12
Design, synthesis and biological evaluation of benzofuran appended benzothiazepine derivatives as inhibitors of butyrylcholinesterase and antimicrobial agents.
AID1870157Antibacterial activity against wild type Staphylococcus aureus 5079/C assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay2022Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14
LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials.
AID1809593Antibacterial activity against Streptococcus pyogenes ATCC 19615 assessed as zone of inhibition at 15 mg/ml2021Bioorganic & medicinal chemistry letters, 11-15, Volume: 52Synthesis, anti-microbial, toxicity and molecular docking studies of N-nitroso-N-phenylhydroxylamine (cupferron) and its derivatives.
AID1524134Bactericidal activity against Salmonella pullorum C7913 incubated for 4 hrs followed by culture spread on agar plates and cultured overnight2019Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5
Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria.
AID1356825Antimicrobial activity against Klebsiella pneumoniae ATCC BAA-1904 by broth microdilution method2018Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
Total Synthesis and Structure-Activity Relationships Study of Odilorhabdins, a New Class of Peptides Showing Potent Antibacterial Activity.
AID1884056Antibacterial activity against Enterococcus faecalis LMG 16216 incubated for 20 hrs by CLSI based broth microdilution method2022Journal of natural products, 06-24, Volume: 85, Issue:6
Chemically Tuning Resveratrol for the Effective Killing of Gram-Positive Pathogens.
AID1713869Antibacterial activity against Salmonella enterica ATCC 14028 assessed as concentration required to inhibit visible growth by CLSI protocol based serial microdilution method2016Bioorganic & medicinal chemistry, 11-15, Volume: 24, Issue:22
Biological evaluation of tetracationic compounds based on two 1,4-diazabicyclo[2.2.2]octane moieties connected by different linkers.
AID1592960Antibacterial activity against multi-drug resistant Klebsiella pneumoniae NMI 3081/09 assessed as reduction in microbial growth incubated for 20 hrs2019European journal of medicinal chemistry, Apr-15, Volume: 168Microwave-assisted solid-phase synthesis of antisense acpP peptide nucleic acid-peptide conjugates active against colistin- and tigecycline-resistant E. coli and K. pneumoniae.
AID1430435Antibacterial activity against Escherichia coli ATCC 25922 after overnight incubation by photometric method2017Bioorganic & medicinal chemistry letters, 03-01, Volume: 27, Issue:5
Synthesis and antimicrobial evaluation of cationic low molecular weight amphipathic 1,2,3-triazoles.
AID1575413Antibacterial activity against Clostridium difficile ATCC 17858 after 16 hrs by agar diffusion method2019Journal of natural products, 01-25, Volume: 82, Issue:1
Antibacterial Aromatic Polyketides Incorporating the Unusual Amino Acid Enduracididine.
AID1391491Antibacterial activity against Pseudomonas aeruginosa assessed as diameter of inhibition zone measured after 24 hrs by agar well diffusion method
AID1524036Antimicrobial activity against Escherichia coli K99 after 24 hrs by NCCLS-protocol based assay2019Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5
Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria.
AID1356822Inhibition of bacterial protein synthesis in cell-free Escherichia coli incubated for 1 hr and measured for every 20 mins by bacterial cell-free transcription-translation assay2018Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
Total Synthesis and Structure-Activity Relationships Study of Odilorhabdins, a New Class of Peptides Showing Potent Antibacterial Activity.
AID1394755Antimicrobial activity against Escherichia coli AS 1.349 assessed as induction of outer membrane permeabilization by measuring NPN uptake up to 50 uM by fluorescence assay2018European journal of medicinal chemistry, Apr-25, Volume: 150Antimicrobial activity and self-assembly behavior of antimicrobial peptide chensinin-1b with lipophilic alkyl tails.
AID1321215Antimicrobial activity against Bacillus subtilis IFO 3007 at 200 ug/disc measured after 24 hrs by agar disc-diffusion method2016Bioorganic & medicinal chemistry letters, 10-01, Volume: 26, Issue:19
Synthesis, biological evaluation and molecular modeling study of some new methoxylated 2-benzylthio-quinazoline-4(3H)-ones as nonclassical antifolates.
AID1463959Antimycobacterial activity MDR/XDR against Mycobacterium tuberculosis isolate 9449/2007 incubated for 14 days by micromethod2017Bioorganic & medicinal chemistry, 10-15, Volume: 25, Issue:20
Development of water-soluble 3,5-dinitrophenyl tetrazole and oxadiazole antitubercular agents.
AID1433219Antibacterial activity against Pseudomonas aeruginosa PA14 after 24 to 48 hrs by serial dilution method2016Journal of natural products, 06-24, Volume: 79, Issue:6
Pyristriatins A and B: Pyridino-Cyathane Antibiotics from the Basidiomycete Cyathus cf. striatus.
AID1524040Antimicrobial activity against Pseudomonas aeruginosa 26305 clinical isolates after 24 hrs by NCCLS-protocol based assay2019Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5
Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria.
AID1524041Antimicrobial activity against Pseudomonas aeruginosa CICC 21625 clinical isolates after 24 hrs by NCCLS-protocol based assay2019Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5
Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria.
AID1884055Antibacterial activity against Enterococcus faecalis LMG 08222 incubated for 20 hrs by CLSI based broth microdilution method2022Journal of natural products, 06-24, Volume: 85, Issue:6
Chemically Tuning Resveratrol for the Effective Killing of Gram-Positive Pathogens.
AID1324847Antimicrobial activity against Escherichia coli ATCC 25922 by CLSI M07-A9 method2016Journal of natural products, 07-22, Volume: 79, Issue:7
Polybrominated Diphenyl Ethers: Structure Determination and Trends in Antibacterial Activity.
AID1296383Antimycobacterial activity against multi drug resistant Mycobacterium tuberculosis 234/2005 after 14 days by microdilution method2016Journal of medicinal chemistry, Mar-24, Volume: 59, Issue:6
Development of 3,5-Dinitrobenzylsulfanyl-1,3,4-oxadiazoles and Thiadiazoles as Selective Antitubercular Agents Active Against Replicating and Nonreplicating Mycobacterium tuberculosis.
AID1778065Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 1556 assessed as inhibition of bacterial growth measured after 16 to 20 hrs by CLSI broth microdilution method
AID1516029Antibacterial activity against Staphylococcus aureus 11011 incubated for 18 to 24 hrs by broth microdilution method2019Journal of medicinal chemistry, 08-08, Volume: 62, Issue:15
Design of Trp-Rich Dodecapeptides with Broad-Spectrum Antimicrobial Potency and Membrane-Disruptive Mechanism.
AID1856916Antibacterial activity against Escherichia coli ATCC 25922 assessed as fold increase in MIC measured after 15 passages by resistance development assay relative to control2022Journal of medicinal chemistry, 10-27, Volume: 65, Issue:20
Improving the Antimicrobial Performance of Amphiphilic Cationic Antimicrobial Peptides Using Glutamic Acid Full-Scan and Positive Charge Compensation Strategies.
AID1416392Antibacterial activity against Escherichia coli at 50 ug/ml incubated for 24 hrs by agar well diffusion method2017MedChemComm, Aug-01, Volume: 8, Issue:8
Synthesis and molecular docking studies of xanthone attached amino acids as potential antimicrobial and anti-inflammatory agents.
AID1884063Antibacterial activity against Clostridium beijerinckii B504 incubated for 24 hrs by CLSI based broth microdilution method2022Journal of natural products, 06-24, Volume: 85, Issue:6
Chemically Tuning Resveratrol for the Effective Killing of Gram-Positive Pathogens.
AID1625611Antibacterial activity against Klebsiella pneumoniae KPC2ST258 after 18 to 24 hrs by Alamar blue dye-based colorimetric assay2016Journal of medicinal chemistry, 06-09, Volume: 59, Issue:11
Thiolactomycin-Based Inhibitors of Bacterial β-Ketoacyl-ACP Synthases with in Vivo Activity.
AID1463962Antimycobacterial activity MDR/XDR against Mycobacterium tuberculosis isolate 8666/2010 incubated for 14 days by micromethod2017Bioorganic & medicinal chemistry, 10-15, Volume: 25, Issue:20
Development of water-soluble 3,5-dinitrophenyl tetrazole and oxadiazole antitubercular agents.
AID1430048Antibacterial activity against Escherichia coli ATCC 9637 by broth microdilution method
AID1416388Antibacterial activity against Bacillus subtilis at 50 ug/ml incubated for 24 hrs by agar well diffusion method2017MedChemComm, Aug-01, Volume: 8, Issue:8
Synthesis and molecular docking studies of xanthone attached amino acids as potential antimicrobial and anti-inflammatory agents.
AID1416389Antibacterial activity against Bacillus subtilis at 75 ug/ml incubated for 24 hrs by agar well diffusion method2017MedChemComm, Aug-01, Volume: 8, Issue:8
Synthesis and molecular docking studies of xanthone attached amino acids as potential antimicrobial and anti-inflammatory agents.
AID1567120Antimicrobial activity against Streptococcus pneumoniae ATCC 49619 incubated for 20 hrs by microdilution method2019European journal of medicinal chemistry, Sep-15, Volume: 178Design, synthesis and biological evaluation of antimicrobial diarylimine and -amine compounds targeting the interaction between the bacterial NusB and NusE proteins.
AID1524123Bactericidal activity against Escherichia coli 078 incubated for 4 hrs followed by culture spread on agar plates and cultured overnight2019Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5
Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria.
AID1422370Antibacterial activity against Pseudomonas aeruginosa PA406 harboring triABC deletion mutant by microdilution assay2018European journal of medicinal chemistry, Sep-05, Volume: 157Broad-spectrum antibacterial amphiphilic aminoglycosides: A new focus on the structure of the lipophilic groups extends the series of active dialkyl neamines.
AID1905202Antibacterial activity against MDR-methicillin-resistant Staphylococcus aureus ATCC BAA-44 assessed as reduction in bacterial growth measured after 18 hrs by broth microdilution method2022Journal of medicinal chemistry, 04-14, Volume: 65, Issue:7
Spermine-Conjugated Short Proline-Rich Lipopeptides as Broad-Spectrum Intracellular Targeting Antibacterial Agents.
AID1321291Antimicrobial activity against Staphylococcus aureus IFO 3060 measured after 24 hrs by microdilution method2016Bioorganic & medicinal chemistry letters, 10-01, Volume: 26, Issue:19
Synthesis, biological evaluation and molecular modeling study of some new methoxylated 2-benzylthio-quinazoline-4(3H)-ones as nonclassical antifolates.
AID1349062Antibacterial activity against Escherichia coli K-12 after 24 hrs by broth microdilution method2018European journal of medicinal chemistry, Jan-01, Volume: 143Synthesis, biological evaluation, and metabolic stability of phenazine derivatives as antibacterial agents.
AID1524032Antimicrobial activity against Escherichia coli ATCC 25922 after 24 hrs by NCCLS-protocol based assay2019Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5
Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria.
AID1265195Antibacterial activity against Proteus vulgaris ATCC 13315 after 24 hrs by microtiter plate method2015Bioorganic & medicinal chemistry letters, Dec-15, Volume: 25, Issue:24
Synthesis, biological activity evaluation and molecular docking studies of novel coumarin substituted thiazolyl-3-aryl-pyrazole-4-carbaldehydes.
AID1870147Antibacterial activity against wild type Staphylococcus aureus 4482/A assessed as reduction in microbial growth incubated for 24 hrs by microdilution assay2022Journal of medicinal chemistry, 07-28, Volume: 65, Issue:14
LEGO-Lipophosphonoxins: A Novel Approach in Designing Membrane Targeting Antimicrobials.
AID1567124Antimicrobial activity against Enterococcus casseliflavus ATCC 25788 incubated for 20 hrs by microdilution method2019European journal of medicinal chemistry, Sep-15, Volume: 178Design, synthesis and biological evaluation of antimicrobial diarylimine and -amine compounds targeting the interaction between the bacterial NusB and NusE proteins.
AID1809599Antibacterial activity against Corynebacterium ATCC 49368 assessed as zone of inhibition at 15 mg/ml2021Bioorganic & medicinal chemistry letters, 11-15, Volume: 52Synthesis, anti-microbial, toxicity and molecular docking studies of N-nitroso-N-phenylhydroxylamine (cupferron) and its derivatives.
AID1416412Antibacterial activity against Bacillus subtilis incubated for 24 hrs by microdilution method2017MedChemComm, Aug-01, Volume: 8, Issue:8
Synthesis and molecular docking studies of xanthone attached amino acids as potential antimicrobial and anti-inflammatory agents.
AID1809827Antimicrobial activity against multidrug-resistant Staphylococcus aureus ATCC BAA-44 assessed as inhibition of bacterial growth by broth dilution method2021Journal of medicinal chemistry, 10-28, Volume: 64, Issue:20
Tandem Repeat of a Short Human Chemerin-Derived Peptide and Its Nontoxic d-Lysine-Containing Enantiomer Display Broad-Spectrum Antimicrobial and Antitubercular Activities.
AID1435685Antibacterial activity against Pseudomonas aeruginosa ATCC 9027 after 24 hrs by broth microdilution method2017European journal of medicinal chemistry, Jan-27, Volume: 126S-substituted 3,5-dinitrophenyl 1,3,4-oxadiazole-2-thiols and tetrazole-5-thiols as highly efficient antitubercular agents.
AID1713861Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 25923 assessed as concentration required to inhibit visible growth by CLSI protocol based serial microdilution method2016Bioorganic & medicinal chemistry, 11-15, Volume: 24, Issue:22
Biological evaluation of tetracationic compounds based on two 1,4-diazabicyclo[2.2.2]octane moieties connected by different linkers.
AID1609312Bactericidal activity against Klebsiella pneumoniae BAA-17062019European journal of medicinal chemistry, Nov-15, Volume: 182Phenylthiazoles with nitrogenous side chain: An approach to overcome molecular obesity.
AID1416393Antibacterial activity against Escherichia coli at 75 ug/ml incubated for 24 hrs by agar well diffusion method2017MedChemComm, Aug-01, Volume: 8, Issue:8
Synthesis and molecular docking studies of xanthone attached amino acids as potential antimicrobial and anti-inflammatory agents.
AID1321292Antimicrobial activity against Bacillus subtilis IFO 3007 measured after 24 hrs by microdilution method2016Bioorganic & medicinal chemistry letters, 10-01, Volume: 26, Issue:19
Synthesis, biological evaluation and molecular modeling study of some new methoxylated 2-benzylthio-quinazoline-4(3H)-ones as nonclassical antifolates.
AID1713866Antibacterial activity against Pseudomonas aeruginosa ATCC 9027 assessed as bacterial growth inhibition by CLSI protocol based serial microdilution method2016Bioorganic & medicinal chemistry, 11-15, Volume: 24, Issue:22
Biological evaluation of tetracationic compounds based on two 1,4-diazabicyclo[2.2.2]octane moieties connected by different linkers.
AID1713878Antibacterial activity against methicillin-resistant Staphylococcus aureus CEMTC 675 assessed as bacterial growth inhibition by CLSI protocol based serial microdilution method2016Bioorganic & medicinal chemistry, 11-15, Volume: 24, Issue:22
Biological evaluation of tetracationic compounds based on two 1,4-diazabicyclo[2.2.2]octane moieties connected by different linkers.
AID1282496Antibacterial activity against multidrug resistant Klebsiella pneumoniae ATCC 700603 after 18 hrs by 2 fold serial dilution method2016Journal of medicinal chemistry, Feb-11, Volume: 59, Issue:3
Activity and Predicted Nephrotoxicity of Synthetic Antibiotics Based on Polymyxin B.
AID1567137Antimicrobial activity against CA-methicillin-resistant Staphylococcus aureus W4 ST338 incubated for 20 hrs by microdilution method2019European journal of medicinal chemistry, Sep-15, Volume: 178Design, synthesis and biological evaluation of antimicrobial diarylimine and -amine compounds targeting the interaction between the bacterial NusB and NusE proteins.
AID1299619Antibacterial activity against Pseudomonas aeruginosa PAO1 ATCC 47085 assessed as increase in outer membrane permeability at 4 times MIC99 by fluorescent probe 1-N-phenylnaphthylamine based fluorescence assay2016Journal of medicinal chemistry, Apr-14, Volume: 59, Issue:7
Antibacterial Diamines Targeting Bacterial Membranes.
AID1730945Antibacterial activity against Staphylococcus aureus MTCC 96 assessed as bacterial growth inhibition2021Bioorganic & medicinal chemistry letters, 03-15, Volume: 36Structure based design, synthesis, and biological evaluation of imidazole derivatives targeting dihydropteroate synthase enzyme.
AID1676980Antimicrobial activity against vancomycin-resistant Enterococcus faecium ATCC 51299 assessed as reduction in microbial growth after 48 hrs by CLSI based broth microdilution method
AID1524131Bactericidal activity against Pseudomonas aeruginosa 25349 clinical isolates incubated for 4 hrs followed by culture spread on agar plates and cultured overnight2019Journal of medicinal chemistry, 03-14, Volume: 62, Issue:5
Antimicrobial Peptides with High Proteolytic Resistance for Combating Gram-Negative Bacteria.
AID1462770Selectivity index, ratio of EC50 for human HepG2 cells to MIC for Streptococcus agalactiae ATCC 123862017Bioorganic & medicinal chemistry, 10-15, Volume: 25, Issue:20
Methyl propiolate and 3-butynone: Starting points for synthesis of amphiphilic 1,2,3-triazole peptidomimetics for antimicrobial evaluation.
AID1695934Antibacterial activity against Staphylococcus aureus ATCC 9144 incubated for 24 hrs by broth dilution method2019European journal of medicinal chemistry, Apr-15, Volume: 168Comprehensive review on the anti-bacterial activity of 1,2,3-triazole hybrids.
AID1539463Antibacterial activity against Acinetobacter baumannii NR 17785 clinical isolates after 18 to 20 hrs in aerobic condition by CLSI-based broth microdilution assay
AID1356835Antimicrobial activity against Escherichia coli ATCC BAA-2469 by broth microdilution method2018Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
Total Synthesis and Structure-Activity Relationships Study of Odilorhabdins, a New Class of Peptides Showing Potent Antibacterial Activity.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (102)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's73 (71.57)24.3611
2020's29 (28.43)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 20.52

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index20.52 (24.57)
Research Supply Index4.63 (2.92)
Research Growth Index4.57 (4.65)
Search Engine Demand Index21.17 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (20.52)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews7 (6.86%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other95 (93.14%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
pyrazinamide
pyrazinecarboxamide : A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of pyrazinoic acid (pyrazine-2-carboxylic acid) with ammonia. A prodrug for pyrazinoic acid, pyrazinecarboxamide is used as part of multidrug regimens for the treatment of tuberculosis.		4.2220monocarboxylic acid amide;
N-acylammonia;
pyrazines		antitubercular agent;
prodrug
spermidine
[no description available]		2.1310polyazaalkane;
triamine		autophagy inducer;
fundamental metabolite;
geroprotector
spermine
[no description available]		2.1310polyazaalkane;
tetramine		antioxidant;
fundamental metabolite;
immunosuppressive agent
1,10-phenanthroline
1,10-phenanthroline: RN given refers to parent cpd; inhibits Zn-dependent metalloproteinases		2.4110phenanthrolineEC 2.7.1.1 (hexokinase) inhibitor;
EC 3.4.19.3 (pyroglutamyl-peptidase I) inhibitor
2,4-dinitrophenol
2,4-Dinitrophenol: A toxic dye, chemically related to trinitrophenol (picric acid), used in biochemical studies of oxidative processes where it uncouples oxidative phosphorylation. It is also used as a metabolic stimulant. (Stedman, 26th ed). dinitrophenol : Members of the class of nitrophenol carrying two nitro substituents.. 2,4-dinitrophenol : A dinitrophenol having the nitro groups at the 2- and 4-positions.		2.1310dinitrophenolallergen;
antiseptic drug;
bacterial xenobiotic metabolite;
geroprotector;
oxidative phosphorylation inhibitor
oxyquinoline
Oxyquinoline: An antiseptic with mild fungistatic, bacteriostatic, anthelmintic, and amebicidal action. It is also used as a reagent and metal chelator, as a carrier for radio-indium for diagnostic purposes, and its halogenated derivatives are used in addition as topical anti-infective agents and oral antiamebics.. quinolin-8-ol : A monohydroxyquinoline that is quinoline substituted by a hydroxy group at position 8. Its fungicidal properties are used for the control of grey mould on vines and tomatoes.		3.3110monohydroxyquinolineantibacterial agent;
antifungal agrochemical;
antiseptic drug;
iron chelator
carbonyl cyanide m-chlorophenyl hydrazone
Carbonyl Cyanide m-Chlorophenyl Hydrazone: A proton ionophore. It is commonly used as an uncoupling agent and inhibitor of photosynthesis because of its effects on mitochondrial and chloroplast membranes.. CCCP : A member of the class of monochlorobenzenes that is benzene substituted by 2-(1,3-dinitrilopropan-2-ylidene)hydrazinyl and chloro groups at positions 1 and 3, respectively. It is a mitochondrial depolarizing agent that induces reactive oxygen species mediated cell death.		3.5110hydrazone;
monochlorobenzenes;
nitrile		antibacterial agent;
geroprotector;
ionophore
celecoxib
[no description available]		3.3110organofluorine compound;
pyrazoles;
sulfonamide;
toluenes		cyclooxygenase 2 inhibitor;
geroprotector;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug
chloroquine
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.. chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.		2.3110aminoquinoline;
organochlorine compound;
secondary amino compound;
tertiary amino compound		anticoronaviral agent;
antimalarial;
antirheumatic drug;
autophagy inhibitor;
dermatologic drug
chloroxine
chloroxine : A monohydroxyquinoline that is quinolin-8-ol in which the hydrogens at positions 5 and 7 have been substituted by chlorine. A synthetic antibacterial prepared by chlorination of quinolin-8-ol, it is used for the treatment of dandruff and seborrhoeic dermatitis of the scalp.		2.4110monohydroxyquinoline;
organochlorine compound		antibacterial agent;
antifungal drug;
antiseborrheic
ciprofloxacin
Ciprofloxacin: A broad-spectrum antimicrobial carboxyfluoroquinoline.. ciprofloxacin : A quinolone that is quinolin-4(1H)-one bearing cyclopropyl, carboxylic acid, fluoro and piperazin-1-yl substituents at positions 1, 3, 6 and 7, respectively.		7.4320aminoquinoline;
cyclopropanes;
fluoroquinolone antibiotic;
N-arylpiperazine;
quinolinemonocarboxylic acid;
quinolone antibiotic;
quinolone;
zwitterion		antibacterial drug;
antiinfective agent;
antimicrobial agent;
DNA synthesis inhibitor;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
environmental contaminant;
topoisomerase IV inhibitor;
xenobiotic
clofazimine
Clofazimine: A fat-soluble riminophenazine dye used for the treatment of leprosy. It has been used investigationally in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in AIDS patients. Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum. (From AMA Drug Evaluations Annual, 1993, p1619). clofazimine : 3-Isopropylimino-3,5-dihydro-phenazine in which the hydrogen at position 5 is substituted substituted by a 4-chlorophenyl group, and that at position 2 is substituted by a (4-chlorophenyl)amino group. A dark red crystalline solid, clofazimine is an antimycobacterial and is one of the main drugs used for the treatment of multi-bacillary leprosy. However, it can cause red/brown discolouration of the skin, so other treatments are often preferred in light-skinned patients.		4.3650monochlorobenzenes;
phenazines		dye;
leprostatic drug;
non-steroidal anti-inflammatory drug
clotrimazole
[no description available]		2.5320conazole antifungal drug;
imidazole antifungal drug;
imidazoles;
monochlorobenzenes		antiinfective agent;
environmental contaminant;
xenobiotic
cloxyquin
cloxyquin: has antitubercular activity; structure in first source		2.4110organochlorine compound;
quinolines
dapsone
[no description available]		3.3110substituted aniline;
sulfone		anti-inflammatory drug;
antiinfective agent;
antimalarial;
leprostatic drug
fluconazole
Fluconazole: Triazole antifungal agent that is used to treat oropharyngeal CANDIDIASIS and cryptococcal MENINGITIS in AIDS.. fluconazole : A member of the class of triazoles that is propan-2-ol substituted at position 1 and 3 by 1H-1,2,4-triazol-1-yl groups and at position 2 by a 2,4-difluorophenyl group. It is an antifungal drug used for the treatment of mucosal candidiasis and for systemic infections including systemic candidiasis, coccidioidomycosis, and cryptococcosis.		5.07110conazole antifungal drug;
difluorobenzene;
tertiary alcohol;
triazole antifungal drug		environmental contaminant;
P450 inhibitor;
xenobiotic
fluorouracil
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.. 5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.		3.0540nucleobase analogue;
organofluorine compound		antimetabolite;
antineoplastic agent;
environmental contaminant;
immunosuppressive agent;
radiosensitizing agent;
xenobiotic
indomethacin
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.. indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.		3.9830aromatic ether;
indole-3-acetic acids;
monochlorobenzenes;
N-acylindole		analgesic;
drug metabolite;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
environmental contaminant;
gout suppressant;
non-steroidal anti-inflammatory drug;
xenobiotic metabolite;
xenobiotic
isoniazid
Hydra: A genus of freshwater polyps in the family Hydridae, order Hydroida, class HYDROZOA. They are of special interest because of their complex organization and because their adult organization corresponds roughly to the gastrula of higher animals.. hydrazide : Compounds derived from oxoacids RkE(=O)l(OH)m (l =/= 0) by replacing -OH by -NRNR2 (R groups are commonly H). (IUPAC).		5.3990carbohydrazideantitubercular agent;
drug allergen
itraconazole
[no description available]		2.2510piperazines
lomefloxacin
lomefloxacin: structure given in first source. lomefloxacin : A fluoroquinolone antibiotic, used (generally as the hydrochloride salt) to treat bacterial infections including bronchitis and urinary tract infections. It is also used to prevent urinary tract infections prior to surgery.		3.3110fluoroquinolone antibiotic;
N-arylpiperazine;
quinolinemonocarboxylic acid;
quinolone antibiotic;
quinolone		antimicrobial agent;
antitubercular agent;
photosensitizing agent
miconazole
Miconazole: An imidazole antifungal agent that is used topically and by intravenous infusion.. 1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]imidazole : A member of the class of imidazoles that is 1-(2,4-dichlorophenyl)-2-(imidazol-1-yl)ethanol in which the hydroxyl hydrogen is replaced by a 2,4-dichlorobenzyl group.. miconazole : A racemate composed of equimolar amounts of (R)- and (S)-miconazole. Used (as its nitrate salt) to treat skin infections such as athlete's foot, jock itch, ringworm and other fungal skin infections. It inhibits the synthesis of ergosterol, a critical component of fungal cell membranes.		3.3110dichlorobenzene;
ether;
imidazoles
nalidixic acid
[no description available]		2.15101,8-naphthyridine derivative;
monocarboxylic acid;
quinolone antibiotic		antibacterial drug;
antimicrobial agent;
DNA synthesis inhibitor
norfloxacin
Norfloxacin: A synthetic fluoroquinolone (FLUOROQUINOLONES) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA GYRASE.. norfloxacin : A quinolinemonocarboxylic acid with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase.		5.93110fluoroquinolone antibiotic;
N-arylpiperazine;
quinolinemonocarboxylic acid;
quinolone antibiotic;
quinolone		antibacterial drug;
DNA synthesis inhibitor;
environmental contaminant;
xenobiotic
ofloxacin
Ofloxacin: A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.. 9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid : An oxazinoquinoline that is 2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinolin-7-one substituted by methyl, carboxy, fluoro, and 4-methylpiperazin-1-yl groups at positions 3, 6, 9, and 10, respectively.. ofloxacin : A racemate comprising equimolar amounts of levofloxacin and dextrofloxacin. It is a synthetic fluoroquinolone antibacterial agent which inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.		5.4903-oxo monocarboxylic acid;
N-arylpiperazine;
N-methylpiperazine;
organofluorine compound;
oxazinoquinoline
aminosalicylic acid
Aminosalicylic Acid: An antitubercular agent often administered in association with ISONIAZID. The sodium salt of the drug is better tolerated than the free acid.. 4-aminosalicylic acid : An aminobenzoic acid that is salicylic acid substituted by an amino group at position 4.		3.3110aminobenzoic acid;
phenols		antitubercular agent
pentamidine
Pentamidine: Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.. pentamidine : A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease.		2.1510aromatic ether;
carboxamidine;
diether		anti-inflammatory agent;
antifungal agent;
calmodulin antagonist;
chemokine receptor 5 antagonist;
EC 2.3.1.48 (histone acetyltransferase) inhibitor;
NMDA receptor antagonist;
S100 calcium-binding protein B inhibitor;
trypanocidal drug;
xenobiotic
pioglitazone
Pioglitazone: A thiazolidinedione and PPAR GAMMA agonist that is used in the treatment of TYPE 2 DIABETES MELLITUS.. pioglitazone : A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity.		3.3110aromatic ether;
pyridines;
thiazolidinediones		antidepressant;
cardioprotective agent;
EC 2.7.1.33 (pantothenate kinase) inhibitor;
EC 6.2.1.3 (long-chain-fatty-acid--CoA ligase) inhibitor;
ferroptosis inhibitor;
geroprotector;
hypoglycemic agent;
insulin-sensitizing drug;
PPARgamma agonist;
xenobiotic
pyrimethamine
Maloprim: contains above 2 cpds		3.3110aminopyrimidine;
monochlorobenzenes		antimalarial;
antiprotozoal drug;
EC 1.5.1.3 (dihydrofolate reductase) inhibitor
sulfamethoxazole
Sulfamethoxazole: A bacteriostatic antibacterial agent that interferes with folic acid synthesis in susceptible bacteria. Its broad spectrum of activity has been limited by the development of resistance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p208). sulfamethoxazole : An isoxazole (1,2-oxazole) compound having a methyl substituent at the 5-position and a 4-aminobenzenesulfonamido group at the 3-position.		3.3110isoxazoles;
substituted aniline;
sulfonamide antibiotic;
sulfonamide		antibacterial agent;
antiinfective agent;
antimicrobial agent;
drug allergen;
EC 1.1.1.153 [sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)] inhibitor;
EC 2.5.1.15 (dihydropteroate synthase) inhibitor;
environmental contaminant;
epitope;
P450 inhibitor;
xenobiotic
gatifloxacin
Gatifloxacin: A fluoroquinolone antibacterial agent and DNA TOPOISOMERASE II inhibitor that is used as an ophthalmic solution for the treatment of BACTERIAL CONJUNCTIVITIS.. gatifloxacin : A monocarboxylic acid that is 4-oxo-1,4-dihydroquinoline-3-carboxylic acid which is substituted on the nitrogen by a cyclopropyl group and at positions 6, 7, and 8 by fluoro, 3-methylpiperazin-1-yl, and methoxy groups, respectively. Gatifloxacin is an antibiotic of the fourth-generation fluoroquinolone family, that like other members of that family, inhibits the bacterial topoisomerase type-II enzymes.		2.5920N-arylpiperazine;
organofluorine compound;
quinolinemonocarboxylic acid;
quinolone antibiotic;
quinolone		antiinfective agent;
antimicrobial agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor
thalidomide
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.. thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.. 2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.		3.3110phthalimides;
piperidones
trimethoprim
Trimethoprim: A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.. trimethoprim : An aminopyrimidine antibiotic whose structure consists of pyrimidine 2,4-diamine and 1,2,3-trimethoxybenzene moieties linked by a methylene bridge.		3.9630aminopyrimidine;
methoxybenzenes		antibacterial drug;
diuretic;
drug allergen;
EC 1.5.1.3 (dihydrofolate reductase) inhibitor;
environmental contaminant;
xenobiotic
donepezil hydrochloride
donepezil hydrochloride : A racemate comprising equimolar amounts of (R)- and (S)- donepezil hydrochloride. Its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.		2.1710
penicillin g
Penicillin G: A penicillin derivative commonly used in the form of its sodium or potassium salts in the treatment of a variety of infections. It is effective against most gram-positive bacteria and against gram-negative cocci. It has also been used as an experimental convulsant because of its actions on GAMMA-AMINOBUTYRIC ACID mediated synaptic transmission.. benzylpenicillin : A penicillin in which the substituent at position 6 of the penam ring is a phenylacetamido group.		4.3950penicillin allergen;
penicillin		antibacterial drug;
drug allergen;
epitope
chloramphenicol
Amphenicol: Chloramphenicol and its derivatives.		6.27120C-nitro compound;
carboxamide;
diol;
organochlorine compound		antibacterial drug;
antimicrobial agent;
Escherichia coli metabolite;
geroprotector;
Mycoplasma genitalium metabolite;
protein synthesis inhibitor
cetrimonium bromide
cetyltrimethylammonium bromide : The organic bromide salt that is the bromide salt of cetyltrimethylammonium; one of the components of the topical antiseptic cetrimide.		2.1310organic bromide salt;
quaternary ammonium salt		detergent;
surfactant
kanamycin a
Kanamycin: Antibiotic complex produced by Streptomyces kanamyceticus from Japanese soil. Comprises 3 components: kanamycin A, the major component, and kanamycins B and C, the minor components.. kanamycin : Kanamycin is a naturally occurring antibiotic complex from Streptomyces kanamyceticus that consists of several components: kanamycin A, the major component (also usually designated as kanamycin), and kanamycins B, C, D and X the minor components.		5.48100kanamycinsbacterial metabolite
edetic acid
Edetic Acid: A chelating agent that sequesters a variety of polyvalent cations such as CALCIUM. It is used in pharmaceutical manufacturing and as a food additive.		2.4110ethylenediamine derivative;
polyamino carboxylic acid;
tetracarboxylic acid		anticoagulant;
antidote;
chelator;
copper chelator;
geroprotector
tyrosine
Tyrosine: A non-essential amino acid. In animals it is synthesized from PHENYLALANINE. It is also the precursor of EPINEPHRINE; THYROID HORMONES; and melanin.. tyrosine : An alpha-amino acid that is phenylalanine bearing a hydroxy substituent at position 4 on the phenyl ring.		2.1510amino acid zwitterion;
erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid;
proteinogenic amino acid;
tyrosine		EC 1.3.1.43 (arogenate dehydrogenase) inhibitor;
fundamental metabolite;
micronutrient;
nutraceutical
methicillin
Methicillin: One of the PENICILLINS which is resistant to PENICILLINASE but susceptible to a penicillin-binding protein. It is inactivated by gastric acid so administered by injection.. methicillin : A penicillin that is 6-aminopenicillanic acid in which one of the amino hydrogens is replaced by a 2,6-dimethoxybenzoyl group.		2.2510penicillin allergen;
penicillin		antibacterial drug
oxacillin
Oxacillin: An antibiotic similar to FLUCLOXACILLIN used in resistant staphylococci infections.. oxacillin : A penicillin antibiotic carrying a 5-methyl-3-phenylisoxazole-4-carboxamide group at position 6beta.		3.8190penicillinantibacterial agent;
antibacterial drug
cycloserine
Cycloserine: Antibiotic substance produced by Streptomyces garyphalus.. D-cycloserine : A 4-amino-1,2-oxazolidin-3-one that has R configuration. It is an antibiotic produced by Streptomyces garyphalus or S. orchidaceus and is used as part of a multi-drug regimen for the treatment of tuberculosis when resistance to, or toxicity from, primary drugs has developed. An analogue of D-alanine, it interferes with bacterial cell wall synthesis in the cytoplasm by competitive inhibition of L-alanine racemase (which forms D-alanine from L-alanine) and D-alanine--D-alanine ligase (which incorporates D-alanine into the pentapeptide required for peptidoglycan formation and bacterial cell wall synthesis).		2.15104-amino-1,2-oxazolidin-3-one;
organonitrogen heterocyclic antibiotic;
organooxygen heterocyclic antibiotic;
zwitterion		antiinfective agent;
antimetabolite;
antitubercular agent;
metabolite;
NMDA receptor agonist
ampicillin
Ampicillin: Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.. ampicillin : A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-phenylacetamido group.		6.74200beta-lactam antibiotic;
penicillin allergen;
penicillin		antibacterial drug
chlorquinaldol
Chlorquinaldol: Local anti-infective agent used for skin, gastrointestinal, and vaginal infections with fungi, protozoa, and certain bacteria. In animals, it causes central nervous system damage and is not administered parenterally. It is also used as antiseptic, fungistat, or deodorant.. chlorquinaldol : A monohydroxyquinoline that is quinolin-8-ol which is substituted by a methyl group at position 2 and by chlorine at positions 5 and 7. An antifungal and antibacterial, it was formerly used for topical treatment of skin conditions and vaginal infections.		2.4110monohydroxyquinoline;
organochlorine compound		antibacterial drug;
antiprotozoal drug;
antiseptic drug
tryptophan
Tryptophan: An essential amino acid that is necessary for normal growth in infants and for NITROGEN balance in adults. It is a precursor of INDOLE ALKALOIDS in plants. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid). It can be a precursor to NIACIN, albeit inefficiently, in mammals.. tryptophan : An alpha-amino acid that is alanine bearing an indol-3-yl substituent at position 3.		2.1510erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid zwitterion;
L-alpha-amino acid;
proteinogenic amino acid;
tryptophan zwitterion;
tryptophan		antidepressant;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
acedapsone
Acedapsone: Acetylated sulfone that is slowly metabolized to give long-term, low blood levels of DAPSONE. It has antimicrobial and antimalarial action, but is mainly used as a depot leprostatic agent.. acedapsone : A sulfone that is dapsone in which both of the amino groups been acetylation. An antimicrobial drug, it also has antimalarial activity.		3.3110acetamides;
anilide;
secondary carboxamide;
sulfone		antimalarial;
antimicrobial drug
bis(4-hydroxyphenyl)sulfone
bis(4-hydroxyphenyl)sulfone: structure and RN in first source. 4,4'-sulfonyldiphenol : A sulfone that is diphenyl sulfone in which both of the para hydrogens have been replaced by hydroxy groups.		3.3110bisphenol;
sulfone		endocrine disruptor;
metabolite
8-hydroxyquinoline-5-sulfonic acid
8-hydroxyquinoline-5-sulfonic acid: RN given refers to parent cpd		2.4110
4,4'-diaminodiphenylmethane
4,4'-diaminodiphenylmethane: RN given refers to parent cpd; structure. 4,4'-diaminodiphenylmethane : An aromatic amine that is diphenylmethane substituted at the 4-position of each benzene ring by an amino group.		3.3110aromatic amineallergen;
carcinogenic agent
1-amino-2-naphthol-4-sulfonic acid
4-amino-3-hydroxynaphthalene-1-sulfonic acid: reagent for removal of chromium(VI) from aqueous solution		2.4110aminonaphthalene;
naphthalenesulfonic acid		mutagen
framycetin
Framycetin: A component of NEOMYCIN that is produced by Streptomyces fradiae. On hydrolysis it yields neamine and neobiosamine B. (From Merck Index, 11th ed). framycetin : A tetracyclic antibacterial agent derived from neomycin, being a glycoside ester of neamine and neobiosamine B.		4.2240aminoglycosideallergen;
antibacterial drug;
Escherichia coli metabolite
4,4'-thiodianiline
4,4'-thiodianiline: structure		3.3110substituted aniline
catechin
Catechin: An antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms.. catechin : Members of the class of hydroxyflavan that have a flavan-3-ol skeleton and its substituted derivatives.. rac-catechin : A racemate comprising equimolar amounts of (+)- and (-)-catechin. (+)-catechin : The (+)-enantiomer of catechin and a polyphenolic antioxidant plant metabolite.		2.1510catechinantioxidant;
plant metabolite
monoacetyldapsone
monoacetyldapsone: used in leprosy chemotherapy. monoacetyldapsone : A secondary carboxamide resulting from acetylation of one of the amino groups of dapsone.		3.3110acetamides;
anilide;
secondary carboxamide;
sulfone
2-nitrofluorene
2-nitrofluorene: RN given refers to cpd with locant with nitro moiety in 2 position. 2-nitrofluorene : A nitroarene that is fluorene substituted by a nitro group at position 2.		2.5720nitroarenecarcinogenic agent;
mutagen
2-anthramine
2-anthramine: structure		2.2110anthracenamine
erythromycin
Erythromycin: A bacteriostatic antibiotic macrolide produced by Streptomyces erythreus. Erythromycin A is considered its major active component. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.. erythromycin : Any of several wide-spectrum macrolide antibiotics obtained from actinomycete Saccharopolyspora erythraea (formerly known as Streptomyces erythraeus).. erythromycin A : An erythromycin that consists of erythronolide A having 2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl and 3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl residues attahced at positions 4 and 6 respectively.		3.780cyclic ketone;
erythromycin
8-hydroxy-2-methylquinoline
8-hydroxy-2-methylquinoline: structure in first source		2.4110hydroxyquinoline
2-phenylbenzothiazole
2-phenylbenzothiazole: structure given in first source		2.1310
ethambutol
Ethambutol: An antitubercular agent that inhibits the transfer of mycolic acids into the cell wall of the tubercle bacillus. It may also inhibit the synthesis of spermidine in mycobacteria. The action is usually bactericidal, and the drug can penetrate human cell membranes to exert its lethal effect. (From Smith and Reynard, Textbook of Pharmacology, 1992, p863). ethambutol : An ethylenediamine derivative that is ethane-1,2-diamine in which one hydrogen attached to each of the nitrogens is sutstituted by a 1-hydroxybutan-2-yl group (S,S-configuration). It is a bacteriostatic antimycobacterial drug, effective against Mycobacterium tuberculosis and some other mycobacteria. It is used (as the dihydrochloride salt) in combination with other antituberculous drugs in the treatment of pulmonary and extrapulmonary tuberculosis; resistant strains of M. tuberculosis are readily produced if ethambutol is used alone.		4.3650ethanolamines;
ethylenediamine derivative		antitubercular agent;
environmental contaminant;
xenobiotic
vancomycin
Vancomycin: Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear.. vancomycin : A complex glycopeptide from Streptomyces orientalis. It inhibits a specific step in the synthesis of the peptidoglycan layer in the Gram-positive bacteria Staphylococcus aureus and Clostridium difficile.		5.97280glycopeptideantibacterial drug;
antimicrobial agent;
bacterial metabolite
spectinomycin
Spectinomycin: An antibiotic produced by Streptomyces spectabilis. It is active against gram-negative bacteria and used for the treatment of GONORRHEA.. spectinomycin dihydrochloride : A hydrochloride obtained by combining spectinomycin with two molar equivalents of hydrochloric acid. An antibiotic that is active against gram-negative bacteria and used (as its pentahydrate) to treat gonorrhea.. spectinomycin : A pyranobenzodioxin and antibiotic that is active against gram-negative bacteria and used (as its dihydrochloride pentahydrate) to treat gonorrhea. It is produced by the bacterium Streptomyces spectabilis.		2.5720cyclic acetal;
cyclic hemiketal;
cyclic ketone;
pyranobenzodioxin;
secondary alcohol;
secondary amino compound		antibacterial drug;
antimicrobial agent;
bacterial metabolite
tetrachloroisophthalonitrile
tetrachloroisophthalonitrile: structure. chlorothalonil : A dinitrile that is benzene-1,3-dicarbonitrile substituted by four chloro groups. A non-systemic fungicide first introduced in the 1960s, it is used to control a range of diseases in a wide variety of crops.		2.2110aromatic fungicide;
dinitrile;
tetrachlorobenzene		antifungal agrochemical
2-(2-hydroxyphenyl)benzothiazole
2-(1,3-benzothiazol-2-yl)phenol : A member of the class of benzothiazoles that is 1,3-benzothiazole substituted by a 2-hydroxyphenyl group at position 2.		2.1310benzothiazoles;
phenols		geroprotector
streptomycin
[no description available]		4.7780antibiotic antifungal drug;
antibiotic fungicide;
streptomycins		antibacterial drug;
antifungal agrochemical;
antimicrobial agent;
antimicrobial drug;
bacterial metabolite;
protein synthesis inhibitor
nitroxoline
nitroxoline: structure in Merck Index, 9th ed, #6475; RN given refers to parent cpd. nitroxoline : A monohydroxyquinoline in which the hydroxy group is positioned at C-8 with a nitro group trans to it at C-5.		2.4110C-nitro compound;
monohydroxyquinoline		antifungal agent;
antiinfective agent;
antimicrobial agent;
renal agent
carbenicillin
Carbenicillin: Broad-spectrum semisynthetic penicillin derivative used parenterally. It is susceptible to gastric juice and penicillinase and may damage platelet function.. carbenicillin : A penicillin antibiotic having a 6beta-2-carboxy-2-phenylacetamido side-chain.		2.1510penicillin allergen;
penicillin		antibacterial drug
carbendazim
carbendazim: carcinogen when combined with sodium nitrite; principle metabolite of thiophanate methyl & benomyl; structure. carbendazim : A member of the class of benzimidazoles that is 2-aminobenzimidazole in which the primary amino group is substituted by a methoxycarbonyl group. A fungicide, carbendazim controls Ascomycetes, Fungi Imperfecti, and Basidiomycetes on a wide variety of crops, including bananas, cereals, cotton, fruits, grapes, mushrooms, ornamentals, peanuts, sugarbeet, soybeans, tobacco, and vegetables.		2.5820benzimidazole fungicide;
benzimidazoles;
benzimidazolylcarbamate fungicide;
carbamate ester		antifungal agrochemical;
antinematodal drug;
metabolite;
microtubule-destabilising agent
cefazolin
Cefazolin: A semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine.. cefazolin : A first-generation cephalosporin compound having [(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]methyl and (1H-tetrazol-1-ylacetyl)amino side-groups at positions 3 and 7 respectively.		2.5420beta-lactam antibiotic allergen;
cephalosporin;
tetrazoles;
thiadiazoles		antibacterial drug
sodium azide
Sodium Azide: A cytochrome oxidase inhibitor which is a nitridizing agent and an inhibitor of terminal oxidation. (From Merck Index, 12th ed). sodium azide : The sodium salt of hydrogen azide (hydrazoic acid).		2.5720inorganic sodium saltantibacterial agent;
explosive;
mitochondrial respiratory-chain inhibitor;
mutagen
amoxicillin
Amoxicillin: A broad-spectrum semisynthetic antibiotic similar to AMPICILLIN except that its resistance to gastric acid permits higher serum levels with oral administration.. amoxicillin : A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-(4-hydroxyphenyl)acetamido group.		2.1510penicillin allergen;
penicillin		antibacterial drug
tobramycin
Tobramycin: An aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteria, especially the PSEUDOMONAS species. It is a 10% component of the antibiotic complex, NEBRAMYCIN, produced by the same species.. tobramycin : A amino cyclitol glycoside that is kanamycin B lacking the 3-hydroxy substituent from the 2,6-diaminoglucose ring.		4.8690amino cyclitol glycosideantibacterial agent;
antimicrobial agent;
toxin
etoposide
[no description available]		2.5920beta-D-glucoside;
furonaphthodioxole;
organic heterotetracyclic compound		antineoplastic agent;
DNA synthesis inhibitor
amikacin
Amikacin: A broad-spectrum antibiotic derived from KANAMYCIN. It is reno- and oto-toxic like the other aminoglycoside antibiotics.. amikacin : An amino cyclitol glycoside that is kanamycin A acylated at the N-1 position by a 4-amino-2-hydroxybutyryl group.		5.2130alpha-D-glucoside;
amino cyclitol glycoside;
aminoglycoside;
carboxamide		antibacterial drug;
antimicrobial agent;
nephrotoxin
acarbose
[no description available]		3.3110tetrasaccharide derivativeEC 3.2.1.1 (alpha-amylase) inhibitor;
EC 3.2.1.20 (alpha-glucosidase) inhibitor;
geroprotector;
hypoglycemic agent
piperacillin
Piperacillin: Semisynthetic, broad-spectrum, AMPICILLIN derived ureidopenicillin antibiotic proposed for PSEUDOMONAS infections. It is also used in combination with other antibiotics.. piperacillin : A penicillin in which the substituent at position 6 of the penam ring is a 2-[(4-ethyl-2,3-dioxopiperazin-1-yl)carboxamido]-2-phenylacetamido group.		2.9830penicillin allergen;
penicillin		antibacterial drug
cefaclor anhydrous
Cefaclor: Semisynthetic, broad-spectrum antibiotic derivative of CEPHALEXIN.. cefaclor : A cephalosporin bearing chloro and (R)-2-amino-2-phenylacetamido groups at positions 3 and 7, respectively, of the cephem skeleton.		3.3110cephalosporinantibacterial drug;
drug allergen
sparfloxacin
[no description available]		3.3110fluoroquinolone antibiotic;
N-arylpiperazine;
quinolinemonocarboxylic acid;
quinolone antibiotic;
quinolone
zileuton
[no description available]		3.31101-benzothiophenes;
ureas		anti-asthmatic drug;
EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor;
ferroptosis inhibitor;
leukotriene antagonist;
non-steroidal anti-inflammatory drug
desferrioxamine b mesylate
desferrioxamine B mesylate : A methanesulfonate salt obtained by reaction of desferrioxamine B with one molar equivalent of methanesulfonic acid. It is an iron-chelating medicine used to remove excess iron from the body. It binds to iron in the blood, which is then passed out in the urine.		2.1510methanesulfonate saltantidote;
ferroptosis inhibitor;
iron chelator
oseltamivir
Oseltamivir: An acetamido cyclohexene that is a structural homolog of SIALIC ACID and inhibits NEURAMINIDASE.. oseltamivir : A cyclohexenecarboxylate ester that is the ethyl ester of oseltamivir acid. An antiviral prodrug (it is hydrolysed to the active free carboxylic acid in the liver), it is used to slow the spread of influenza.		2.1310acetamides;
amino acid ester;
cyclohexenecarboxylate ester;
primary amino compound		antiviral drug;
EC 3.2.1.18 (exo-alpha-sialidase) inhibitor;
environmental contaminant;
prodrug;
xenobiotic
4-amino-4'-hydroxylaminodiphenylsulfone
4-amino-4'-hydroxylaminodiphenylsulfone: RN given refers to unlabeled cpd		3.3110sulfonic acid derivative
acediasulfone
acediasulfone: antibacterial drug for treatment of ear infections; structure in first source		3.3110alpha-amino acid
brodimoprim
brodimoprim: inhibits dihydrofolate reductase. brodimoprim : An aminopyrimidine that is 2,4-diaminopyrimidine in which the hydrogen at position 5 has been replaced by a 4-bromo-3,5-dimethoxybenzyl group.		3.3110aminopyrimidine;
bromobenzenes;
methoxybenzenes		antibacterial drug;
antiinfective agent;
EC 1.5.1.3 (dihydrofolate reductase) inhibitor
epiroprim
epiroprim: an analog of trimethoprim with improved antimicrobial and pharmacokinetic properties; structure given in first source		3.3110
neamine
neamine: fragment of NEOMYCIN B; structure in first source. neamine : 2-Deoxy-D-streptamine glycosylated at the 4-oxygen with a 6-amino-alpha-D-glucosaminyl group.		2.55202,6-dideoxy-alpha-D-glucoside;
aminoglycoside		antibacterial agent
doripenem
Doripenem: A carbapenem derivative antibacterial agent that is more stable to renal dehydropeptidase I than IMIPENEM, but does not need to be given with an enzyme inhibitor such as CILASTATIN. It is used in the treatment of infections such as HOSPITAL-ACQUIRED PNEUMONIA, and complicated intra-abdominal or urinary-tract infections, including PYELONEPHRITIS.		2.1310carbapenems
8-hydroxy-2-quinolinecarboxylic acid
[no description available]		2.4110quinolines
4-nitro-4'-aminodiphenyl sulfone
4-nitro-4'-aminodiphenyl sulfone: dapsone metabolite; structure given in first source		3.3110
rosiglitazone
[no description available]		3.3110aminopyridine;
thiazolidinediones		EC 6.2.1.3 (long-chain-fatty-acid--CoA ligase) inhibitor;
ferroptosis inhibitor;
insulin-sensitizing drug
clarithromycin
Clarithromycin: A semisynthetic macrolide antibiotic derived from ERYTHROMYCIN that is active against a variety of microorganisms. It can inhibit PROTEIN SYNTHESIS in BACTERIA by reversibly binding to the 50S ribosomal subunits. This inhibits the translocation of aminoacyl transfer-RNA and prevents peptide chain elongation.. clarithromycin : The 6-O-methyl ether of erythromycin A, clarithromycin is a macrolide antibiotic used in the treatment of respiratory-tract, skin and soft-tissue infections. It is also used to eradicate Helicobacter pylori in the treatment of peptic ulcer disease. It prevents bacteria from growing by interfering with their protein synthesis.		2.5420macrolide antibioticantibacterial drug;
environmental contaminant;
protein synthesis inhibitor;
xenobiotic
2-(2'-hydroxy-3'-methoxyphenyl)benzothiazole
2-(2'-hydroxy-3'-methoxyphenyl)benzothiazole: structure in first source		2.1310
2,8-dihydroxyquinoline
[no description available]		2.4110dihydroxyquinoline;
monohydroxyquinoline;
quinolone
imipenem, anhydrous
Imipenem: Semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains. It is stable to beta-lactamases. Clinical studies have demonstrated high efficacy in the treatment of infections of various body systems. Its effectiveness is enhanced when it is administered in combination with CILASTATIN, a renal dipeptidase inhibitor.. imipenem : A broad-spectrum, intravenous beta-lactam antibiotic of the carbapenem subgroup.		4.6770beta-lactam antibiotic allergen;
carbapenems;
zwitterion		antibacterial drug
methotrexate
[no description available]		3.6620dicarboxylic acid;
monocarboxylic acid amide;
pteridines		abortifacient;
antimetabolite;
antineoplastic agent;
antirheumatic drug;
dermatologic drug;
DNA synthesis inhibitor;
EC 1.5.1.3 (dihydrofolate reductase) inhibitor;
immunosuppressive agent
levofloxacin
Levofloxacin: The L-isomer of Ofloxacin.. levofloxacin : An optically active form of ofloxacin having (S)-configuration; an inhibitor of bacterial topoisomerase IV and DNA gyrase.		5.08609-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid;
fluoroquinolone antibiotic;
quinolone antibiotic		antibacterial drug;
DNA synthesis inhibitor;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
topoisomerase IV inhibitor
moxifloxacin
Moxifloxacin: A fluoroquinolone that acts as an inhibitor of DNA TOPOISOMERASE II and is used as a broad-spectrum antibacterial agent.. moxifloxacin : A quinolone that consists of 4-oxo-1,4-dihydroquinoline-3-carboxylic acid bearing a cyclopropyl substituent at position 1, a fluoro substitiuent at position 6, a (4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl group at position 7 and a methoxy substituent at position 8. A member of the fluoroquinolone class of antibacterial agents.		2.8630aromatic ether;
cyclopropanes;
fluoroquinolone antibiotic;
pyrrolidinopiperidine;
quinolinemonocarboxylic acid;
quinolone antibiotic;
quinolone		antibacterial drug
drummondin c
drummondin C: structure given in first source; isolated from the weed nits-and-lice (Hypericum drummondii); shows activity against some Gram-positive and Gram-negative bacteria		2.2110
paromomycin
Paromomycin: An aminoglycoside antibacterial and antiprotozoal agent produced by species of STREPTOMYCES.. paromomycin : An amino cyclitol glycoside that is the 1-O-(2-amino-2-deoxy-alpha-D-glucopyranoside) and the 3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranoside of 4,6-diamino-2,3-dihydroxycyclohexane (the 1R,2R,3S,4R,6S diastereoisomer). It is obtained from various Streptomyces species. A broad-spectrum antibiotic, it is used (generally as the sulfate salt) for the treatment of acute and chronic intestinal protozoal infections, but is not effective for extraintestinal protozoal infections. It is also used as a therapeutic against visceral leishmaniasis.		3.3510amino cyclitol glycoside;
aminoglycoside antibiotic		anthelminthic drug;
antibacterial drug;
antiparasitic agent;
antiprotozoal drug
aminopterin
Aminopterin: A folic acid derivative used as a rodenticide that has been shown to be teratogenic.		3.3110dicarboxylic acidEC 1.5.1.3 (dihydrofolate reductase) inhibitor;
mutagen
vincaleukoblastine
[no description available]		3.3110acetate ester;
indole alkaloid fundamental parent;
methyl ester;
organic heteropentacyclic compound;
organic heterotetracyclic compound;
tertiary alcohol;
tertiary amino compound;
vinca alkaloid		antineoplastic agent;
immunosuppressive agent;
microtubule-destabilising agent;
plant metabolite
bekanamycin
bekanamycin: kanendomycin is the sulfate of bekanamycin; RN given refers to parent cpd; structure		2.3110kanamycins
meropenem
Meropenem: A thienamycin derivative antibacterial agent that is more stable to renal dehydropeptidase I than IMIPENEM, but does not need to be given with an enzyme inhibitor such as CILASTATIN. It is used in the treatment of bacterial infections, including infections in immunocompromised patients.. meropenem : A carbapenemcarboxylic acid in which the azetidine and pyrroline rings carry 1-hydroxymethyl and in which the azetidine and pyrroline rings carry 1-hydroxymethyl and 5-(dimethylcarbamoyl)pyrrolidin-3-ylthio substituents respectively.		3.4760alpha,beta-unsaturated monocarboxylic acid;
carbapenemcarboxylic acid;
organic sulfide;
pyrrolidinecarboxamide		antibacterial agent;
antibacterial drug;
drug allergen
griseofulvin
Griseofulvin: An antifungal agent used in the treatment of TINEA infections.. griseofulvin : An oxaspiro compound produced by Penicillium griseofulvum. It is used by mouth as an antifungal drug for infections involving the scalp, hair, nails and skin that do not respond to topical treatment.		2.59201-benzofurans;
antibiotic antifungal drug;
benzofuran antifungal drug;
organochlorine compound;
oxaspiro compound		antibacterial agent;
Penicillium metabolite
cefoxitin
Cefoxitin: A semisynthetic cephamycin antibiotic resistant to beta-lactamase.. cefoxitin : A semisynthetic cephamycin antibiotic which, in addition to the methoxy group at the 7alpha position, has 2-thienylacetamido and carbamoyloxymethyl side-groups. It is resistant to beta-lactamase.		2.5520beta-lactam antibiotic allergen;
cephalosporin;
cephamycin;
semisynthetic derivative		antibacterial drug
kanamycin sulfate
[no description available]		2.1310aminoglycoside sulfate saltantibacterial drug;
geroprotector
linezolid
[no description available]		4.9390acetamides;
morpholines;
organofluorine compound;
oxazolidinone		antibacterial drug;
protein synthesis inhibitor
doxorubicin hydrochloride
[no description available]		3.9530anthracycline
resveratrol
trans-resveratrol : A resveratrol in which the double bond has E configuration.		3.5110resveratrolantioxidant;
phytoalexin;
plant metabolite;
quorum sensing inhibitor;
radical scavenger
mupirocin
Mupirocin: A topically used antibiotic from a strain of Pseudomonas fluorescens. It has shown excellent activity against gram-positive staphylococci and streptococci. The antibiotic is used primarily for the treatment of primary and secondary skin disorders, nasal infections, and wound healing.. mupirocin : An alpha,beta-unsaturated ester resulting from the formal condensation of the alcoholic hydroxy group of 9-hydroxynonanoic acid with the carboxy group of (2E)-4-[(2S)-tetrahydro-2H-pyran-2-yl]-3-methylbut-2-enoic acid in which the tetrahydropyranyl ring is substituted at positions 3 and 4 by hydroxy groups and at position 5 by a {(2S,3S)-3-[(2S,3S)-3-hydroxybutan-2-yl]oxiran-2-yl}methyl group. Originally isolated from the Gram-negative bacterium Pseudomonas fluorescens, it is used as a topical antibiotic for the treatment of Gram-positive bacterial infections.		2.5520alpha,beta-unsaturated carboxylic ester;
epoxide;
monocarboxylic acid;
oxanes;
secondary alcohol;
triol		antibacterial drug;
bacterial metabolite;
protein synthesis inhibitor
clindamycin
Clindamycin: An antibacterial agent that is a semisynthetic analog of LINCOMYCIN.. clindamycin : A carbohydrate-containing antibiotic that is the semisynthetic derivative of lincomycin, a natural antibiotic.		2.6320
fosfomycin
Fosfomycin: An antibiotic produced by Streptomyces fradiae.. fosfomycin : A phosphonic acid having an (R,S)-1,2-epoxypropyl group attached to phosphorus.		2.2110epoxide;
phosphonic acids		antimicrobial agent;
EC 2.5.1.7 (UDP-N-acetylglucosamine 1-carboxyvinyltransferase) inhibitor
zithromax
Azithromycin: A semi-synthetic macrolide antibiotic structurally related to ERYTHROMYCIN. It has been used in the treatment of Mycobacterium avium intracellulare infections, toxoplasmosis, and cryptosporidiosis.. azithromycin : A macrolide antibiotic useful for the treatment of bacterial infections.		3.3110macrolide antibioticantibacterial drug;
environmental contaminant;
xenobiotic
epothilone b
[no description available]		2.5820epothilone;
epoxide		antineoplastic agent;
apoptosis inducer;
microtubule-stabilising agent
epothilone a
Epothilones: A group of 16-member MACROLIDES which stabilize MICROTUBULES in a manner similar to PACLITAXEL. They were originally found in the myxobacterium Sorangium cellulosum, now renamed to Polyangium (MYXOCOCCALES).		2.1310epothilone;
epoxide		antineoplastic agent;
metabolite;
microtubule-stabilising agent;
tubulin modulator
pa 824
pretomanid: nitroimidazopyran derived from 5-nitroimidazoles; a prodrug that requires activation by a bacterial F420-depedent glucose-6-phosphate dehydrogenase (Fgd) and nitroreductase to activate components that then inhibit bacterial mycolic acid and protein synthesis; structure in first source		2.2110
ketoconazole
(2R,4S)-ketoconazole : A cis-1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine which dioxolane moiety has (2R,4S)-configuration.		2.1710cis-1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine
5-carboxy-8-hydroxyquinoline
5-carboxy-8-hydroxyquinoline: a JmjC histone demethylase inhibitor; structure in first source		2.4110quinolines
sitafloxacin
[no description available]		3.3110fluoroquinolone antibiotic;
quinolines;
quinolone antibiotic
9-benzyl-2-chloro-6-(2-furyl)purine
9-benzyl-2-chloro-6-(2-furyl)purine: structure in first source		3.3110
n,n'-ethylenediamine disuccinic acid
N,N'-ethylenediamine disuccinic acid: from Actinomycetes MG417-CF17; structure given in first source		2.4110
bekanamycin sulfate
[no description available]		2.4110aminoglycoside sulfate salt
1-benzyl-2-phenylbenzimidazole
1-benzyl-2-phenylbenzimidazole: has antineoplastic activity; structure in first source		2.2510
tamoxifen
[no description available]		2.3110stilbenoid;
tertiary amino compound		angiogenesis inhibitor;
antineoplastic agent;
bone density conservation agent;
EC 1.2.3.1 (aldehyde oxidase) inhibitor;
EC 2.7.11.13 (protein kinase C) inhibitor;
estrogen antagonist;
estrogen receptor antagonist;
estrogen receptor modulator
ethionamide
Ethionamide: A second-line antitubercular agent that inhibits mycolic acid synthesis.. ethionamide : A thiocarboxamide that is pyridine-4-carbothioamide substituted by an ethyl group at position 2. A prodrug that undergoes metabolic activation by conversion to the corresponding S-oxide.		3.3110pyridines;
thiocarboxamide		antilipemic drug;
antitubercular agent;
fatty acid synthesis inhibitor;
leprostatic drug;
prodrug
5-nitro-8-(1-pyrrolidinyl)quinoline
[no description available]		2.4110nitro compound;
quinolines
fusidic acid
Fusidic Acid: An antibiotic isolated from the fermentation broth of Fusidium coccineum. (From Merck Index, 11th ed). It acts by inhibiting translocation during protein synthesis.. fusidic acid : A steroid antibiotic that is isolated from the fermentation broth of Fusidium coccineum.		2.552011alpha-hydroxy steroid;
3alpha-hydroxy steroid;
alpha,beta-unsaturated monocarboxylic acid;
steroid acid;
steroid antibiotic;
sterol ester		EC 2.7.1.33 (pantothenate kinase) inhibitor;
Escherichia coli metabolite;
protein synthesis inhibitor
quinine
[no description available]		2.3110cinchona alkaloidantimalarial;
muscle relaxant;
non-narcotic analgesic
3,5-dibromo-2-(2,4-dibromophenoxy)phenol
3,5-dibromo-2-(2,4-dibromophenoxy)phenol: isolated from the marine sponge Callyspongidae; inhibits contraction of smooth muscle in ileum; structure in first source		2.1310
resveratrol-4'-o-glucuronide
resveratrol-4'-O-glucuronide: structure in first source		3.5110glycoside;
stilbenoid
amphotericin b
Amphotericin B: Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.. amphotericin B : A macrolide antibiotic used to treat potentially life-threatening fungal infections.		5.15120antibiotic antifungal drug;
macrolide antibiotic;
polyene antibiotic		antiamoebic agent;
antiprotozoal drug;
bacterial metabolite
rottlerin
rottlerin: an angiogenesis inhibitor; an inhibitor of protein kinase Cdelta (PKCdelta) and calmodulin kinase III; RN refers to (E)-isomer; do not confuse this chalcone with an anthraquinone that is also called rottlerin (RN 481-72-1);. rottlerin : A chromenol that is 2,2-dimethyl-2H-chromene substituted by hydroxy groups at positions 5 and 7, a 3-acetyl-2,4,6-trihydroxy-5-methylbenzyl group at position 6 and a (1E)-3-oxo-1-phenylprop-1-en-3-yl group at position 8. A potassium channel opener, it is isolated from Mallotus philippensis.		2.6120aromatic ketone;
benzenetriol;
chromenol;
enone;
methyl ketone		anti-allergic agent;
antihypertensive agent;
antineoplastic agent;
apoptosis inducer;
K-ATP channel agonist;
metabolite
cerulenin
Cerulenin: An epoxydodecadienamide isolated from several species, including ACREMONIUM, Acrocylindrum, and Helicoceras. It inhibits the biosynthesis of several lipids by interfering with enzyme function.. cerulenin : An epoxydodecadienamide isolated from several species, including Acremonium, Acrocylindrum and Helicoceras. It inhibits the biosynthesis of several lipids by interfering with enzyme function.		4.0630epoxide;
monocarboxylic acid amide		antifungal agent;
antiinfective agent;
antilipemic drug;
antimetabolite;
antimicrobial agent;
fatty acid synthesis inhibitor
demycarosylturimycin h
[no description available]		3.3110
warangalone
warangalone: structure in first source		2.2110
3,4',5-trimethoxystilbene
3,4',5-trimethoxystilbene: structure in first source		3.5110
bedaquiline
bedaquiline: a diarylquinoline Antitubercular Agent. bedaquiline : A quinoline-based antimycobacterial drug used (as its fumarate salt) for the treatment of pulmonary multi-drug resistant tuberculosis by inhibition of ATP synthase, an enzyme essential for the replication of the mycobacteria.		2.2110aromatic ether;
naphthalenes;
organobromine compound;
quinolines;
tertiary alcohol;
tertiary amino compound		antitubercular agent;
ATP synthase inhibitor
cefuroxime
[no description available]		2.41103-(carbamoyloxymethyl)cephalosporin;
furans;
oxime O-ether		drug allergen
ceftriaxone
[no description available]		2.57201,2,4-triazines;
1,3-thiazoles;
cephalosporin;
oxime O-ether		antibacterial drug;
drug allergen;
EC 3.5.2.6 (beta-lactamase) inhibitor
cefepime
Cefepime: A fourth-generation cephalosporin antibacterial agent that is used in the treatment of infections, including those of the abdomen, urinary tract, respiratory tract, and skin. It is effective against PSEUDOMONAS AERUGINOSA and may also be used in the empiric treatment of FEBRILE NEUTROPENIA.. cefepime : A cephalosporin bearing (1-methylpyrrolidinium-1-yl)methyl and (2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido groups at positions 3 and 7, respectively, of the cephem skeleton.		2.5720cephalosporin;
oxime O-ether		antibacterial drug
ceftazidime
[no description available]		3.5970cephalosporin;
oxime O-ether		antibacterial drug;
drug allergen;
EC 2.4.1.129 (peptidoglycan glycosyltransferase) inhibitor
(6R,7R)-7-[[(2R)-2-carboxy-2-(4-hydroxyphenyl)-1-oxoethyl]amino]-7-methoxy-3-[[(1-methyl-5-tetrazolyl)thio]methyl]-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
[no description available]		2.2110dicarboxylic acid;
secondary carboxamide
cefotaxime
Cefotaxime: Semisynthetic broad-spectrum cephalosporin.. cefotaxime : A cephalosporin compound having acetoxymethyl and [2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino side groups.		2.58201,3-thiazoles;
cephalosporin;
oxime O-ether		antibacterial drug;
drug allergen
aztreonam
[no description available]		2.5720beta-lactam antibiotic allergen;
monobactam		antibacterial drug;
drug allergen;
EC 2.4.1.129 (peptidoglycan glycosyltransferase) inhibitor
opc-67683
OPC-67683: an antitubercular agent		2.5820piperidines
nitrofurantoin
Nitrofurantoin: A urinary anti-infective agent effective against most gram-positive and gram-negative organisms. Although sulfonamides and antibiotics are usually the agents of choice for urinary tract infections, nitrofurantoin is widely used for prophylaxis and long-term suppression.. nitrofurantoin : An imidazolidine-2,4-dione that is hydantoin substituted at position 1 by a [(5-nitro-2-furyl)methylene]amino group. An antibiotic that damages bacterial DNA.		2.1510imidazolidine-2,4-dione;
nitrofuran antibiotic;
organonitrogen heterocyclic antibiotic;
organooxygen heterocyclic antibiotic		antibacterial drug;
antiinfective agent;
hepatotoxic agent
roxithromycin
(E)-roxithromycin : A major geometrical isomer of roxithromycin.		2.1510roxithromycinenvironmental contaminant;
xenobiotic
cajanine
cajanine: isolated from Cajanus cajan L.; structure in first source		2.3110stilbenoid
2-phenylbenzothiazole
PBT2 compound: a metal-protein-attenuating compound that may be useful in treating Alzheimer's disesae		2.4110
polymyxin b(1)
[no description available]		3.3150
nystatin a1
Nystatin: Macrolide antifungal antibiotic complex produced by Streptomyces noursei, S. aureus, and other Streptomyces species. The biologically active components of the complex are nystatin A1, A2, and A3.. nystatin : A heterogeneous mixture of polyene compounds produced by cultures of Streptomyces noursei. It mainly consists of three biologically active components designated nystatin A1, nystatin A2, and nystatin A3. It is used to treat oral and dermal fungal infections.. nystatin A1 : A polyene macrolide antibiotic; part of the nystatin complex produced by several Streptomyces species. It is an antifungal antibiotic used for the treatment of topical fungal infections caused by a broad spectrum of fungal pathogens comprising yeast-like and filamentous species.		4.5460nystatins
4,6-dibromo-2-(2',4'-dibromo)phenoxyanisole
4,6-dibromo-2-(2',4'-dibromo)phenoxyanisole: a brominated compound, detected in the blubber of dolphins and other marine mammals from Queensland (northeast Australia)		2.1310
pexiganan
[no description available]		2.2510
forapin
Forapin: used as ointment for treatment of myositis & arthritis; contains bee venom, salicylate, nicotinate & vanillylnonamide		3.6170peptidyl amide;
polypeptide		animal metabolite;
antineoplastic agent;
apoptosis inducer;
EC 2.7.11.13 (protein kinase C) inhibitor;
hepatoprotective agent;
neuroprotective agent;
venom
btz 043
[no description available]		2.8530
achn 490
plazomicin: structure in first source		3.3510
ascorbic acid
Ascorbic Acid: A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.. L-ascorbic acid : The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate.. L-ascorbate : The L-enantiomer of ascorbate and conjugate base of L-ascorbic acid, arising from selective deprotonation of the 3-hydroxy group. Required for a range of essential metabolic reactions in all animals and plants.. vitamin C : Any member of a group of vitamers that belong to the chemical structural class called butenolides that exhibit biological activity against vitamin C deficiency in animals. The vitamers include L-ascorbic acid and its salt, ionized and oxidized forms.		3.7620ascorbic acid;
vitamin C		coenzyme;
cofactor;
flour treatment agent;
food antioxidant;
food colour retention agent;
geroprotector;
plant metabolite;
skin lightening agent
novobiocin
Novobiocin: An antibiotic compound derived from Streptomyces niveus. It has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, and blocks adenosine triphosphatase (ATPase) activity. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p189). novobiocin : A coumarin-derived antibiotic obtained from Streptomyces niveus.		2.1510carbamate ester;
ether;
hexoside;
hydroxycoumarin;
monocarboxylic acid amide;
monosaccharide derivative;
phenols		antibacterial agent;
antimicrobial agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
Escherichia coli metabolite;
hepatoprotective agent
tetracycline
Tetracycline: A naphthacene antibiotic that inhibits AMINO ACYL TRNA binding during protein synthesis.. tetracycline : A broad-spectrum polyketide antibiotic produced by the Streptomyces genus of actinobacteria.		3.87100
oxytetracycline, anhydrous
Oxytetracycline: A TETRACYCLINE analog isolated from the actinomycete STREPTOMYCES RIMOSUS and used in a wide variety of clinical conditions.. oxytetracycline : A tetracycline used for treatment of infections caused by a variety of Gram positive and Gram negative microorganisms including Mycoplasma pneumoniae, Pasteurella pestis, Escherichia coli, Haemophilus influenzae (respiratory infections), and Diplococcus pneumoniae.		2.5820
minocycline
Minocycline: A TETRACYCLINE analog, having a 7-dimethylamino and lacking the 5 methyl and hydroxyl groups, which is effective against tetracycline-resistant STAPHYLOCOCCUS infections.. minocycline : A tetracycline analogue having a dimethylamino group at position 7 and lacking the methyl and hydroxy groups at position 5.		2.8630
tigecycline
[no description available]		2.2110
pbtz169
macozinone: an antitubercular agent; structure in first source		2.5820
rifampin
Rifampin: A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)		5.64200cyclic ketal;
hydrazone;
N-iminopiperazine;
N-methylpiperazine;
rifamycins;
semisynthetic derivative;
zwitterion		angiogenesis inhibitor;
antiamoebic agent;
antineoplastic agent;
antitubercular agent;
DNA synthesis inhibitor;
EC 2.7.7.6 (RNA polymerase) inhibitor;
Escherichia coli metabolite;
geroprotector;
leprostatic drug;
neuroprotective agent;
pregnane X receptor agonist;
protein synthesis inhibitor
thiolactomycin
thiolactomycin: from actinomycetes; structure given in first source		3.6620
rifabutin
[no description available]		3.3110
3'-hydroxy-5'-(4-isobutylpiperazinyl)benzoxazinorifamycin
KRM 1648: structure in first source		3.3110phenoxazine
krm 1657
KRM 1657: structure given in first source		3.3110
ConditionIndicatedRelationship StrengthStudiesTrials
Bacterial Disease
[description not available]		04.3260
Benign Neoplasms
[description not available]		02.5320
Bacterial Infections
Infections by bacteria, general or unspecified.		04.3260
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		02.5320
Bacterial Infections, Gram-Negative
[description not available]		02.1310
Gram-Negative Bacterial Infections
Infections caused by bacteria that show up as pink (negative) when treated by the gram-staining method.		02.1310
Leukemia, Acute Monocytic
[description not available]		02.1310
Leukemia, Monocytic, Acute
An acute myeloid leukemia in which 80% or more of the leukemic cells are of monocytic lineage including monoblasts, promonocytes, and MONOCYTES.		02.1310
Latent Tuberculosis
The dormant form of TUBERCULOSIS where the person shows no obvious symptoms and no sign of the causative agent (Mycobacterium tuberculosis) in the SPUTUM despite being positive for tuberculosis infection skin test.		02.1310
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.5920
Infections, Klebsiella
[description not available]		02.5520
Infections, Staphylococcal
[description not available]		03.1140
Klebsiella Infections
Infections with bacteria of the genus KLEBSIELLA.		02.5520
Staphylococcal Infections
Infections with bacteria of the genus STAPHYLOCOCCUS.		03.1140
Koch's Disease
[description not available]		02.1310
Tuberculosis
Any of the infectious diseases of man and other animals caused by species of MYCOBACTERIUM TUBERCULOSIS.		02.1310
Infections, Pseudomonas
[description not available]		02.8730
Pseudomonas Infections
Infections with bacteria of the genus PSEUDOMONAS.		02.8730
Infections, Mycobacterium
[description not available]		02.1310
Mycobacterium Infections
Infections with bacteria of the genus MYCOBACTERIUM.		02.1310
Extravascular Hemolysis
[description not available]		03.0840
Hemolysis
The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.		03.0840
Experimental Neoplasms
[description not available]		02.1510
Infections, Respiratory
[description not available]		02.1710
Respiratory Tract Infections
Invasion of the host RESPIRATORY SYSTEM by microorganisms, usually leading to pathological processes or diseases.		02.1710
Hansen Disease
[description not available]		03.1210
Leprosy
A chronic granulomatous infection caused by MYCOBACTERIUM LEPRAE. The granulomatous lesions are manifested in the skin, the mucous membranes, and the peripheral nerves. Two polar or principal types are lepromatous and tuberculoid.		03.1210
Obesity
A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).		02.2110
Bacterial Eye Infections
[description not available]		02.2510
Keratitis
Inflammation of the cornea.		02.2510
Dermatoses
[description not available]		02.3110
Skin Diseases
Diseases involving the DERMIS or EPIDERMIS.		02.3110
Health Care Associated Infection
[description not available]		02.4110
Cross Infection
Any infection which a patient contracts in a health-care institution.		02.4110
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