Any inhibitor added to nitrogen fertilizers which can reduce the rate at which ammonium is converted to nitrate. Under appropriate conditions, this can help reduce nitrogen losses through denitrification and leaching.
ChEBI ID: 148436
| Member | Definition | Class |
|---|---|---|
| 2-amino-4-chloro-6-methylpyrimidine | An aminopyrimidine compound having its amino group at position 2 and chloro and methyl substituents at positions 4 and 6 respectively. | 2-amino-4-chloro-6-methylpyrimidine |
| 3,4-dimethylpyrazole phosphate | A phosphate salt obtained by reacting 3,4-dimethyl-1H-pyrazole with one equivalent of phosphoric acid. It is a nitrification inhibitor and when used on crops, it prevents nitrogen loss from soil, increases nitrogen use efficiency, and boosts crop yields. | 3,4-dimethyl-1H-pyrazole phosphate |
| dicyandiamido | A guanidine in which one of the amino hydrogens of guanidine itself is substituted by a cyano group. It is used in the manufacture of fertilizers, pharmaceuticals, explosives, oil well drilling muds, and dyestuffs. | cyanoguanidine |
| etridiazol | A member of the class of thiadiazoles that is 1,2,4-thiadiazole which is substituted at positions 3 and 5 by trichloromethyl and ethoxy groups, respectively. A fungicide, it has been used particularly for the control of Phytophthora and Pythium species in soils. | etridiazole |
| methyl 3-(4-hydroxyphenyl)propionate | A methyl ester resulting from the formal condensation of the carboxy group of phloretic acid with methanol. It is a nitrification inhibitor and a plant growth regulator. | methyl 3-(4-hydroxyphenyl)propionate |
| nitrapyrin | A chloropyridine that is 2-chloropyridine which is substituted by a trichloromethyl group at position 6. It is a nitrification inhibitor that is co-applied with nitrogen fertilizer in agroecosystems. | nitrapyrin |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 26 (9.96) | 18.7374 |
| 1990's | 18 (6.90) | 18.2507 |
| 2000's | 55 (21.07) | 29.6817 |
| 2010's | 121 (46.36) | 24.3611 |
| 2020's | 41 (15.71) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 10 (3.45%) | 6.00% |
| Case Studies | 2 (0.69%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 278 (95.86%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| acetylcholinesterase | Homo sapiens (human) | Potency | 89.3584 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 62.1132 | 2 | 2 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 48.5197 | 2 | 3 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 12.5893 | 2 | 2 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 6.3955 | 2 | 2 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 5.2720 | 3 | 3 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 60.6336 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 37.6865 | 2 | 2 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 12.1972 | 1 | 1 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 0.0562 | 1 | 1 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 18.6799 | 3 | 3 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| cardiac alpha tropomyosin | Sus scrofa (pig) | EC50 | 71.3750 | 1 | 1 |
| regulator of G-protein signaling 16 | Homo sapiens (human) | EC50 | 30.0000 | 1 | 1 |
| regulator of G-protein signaling 19 | Homo sapiens (human) | EC50 | 30.0000 | 1 | 1 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | EC50 | 30.0000 | 1 | 1 |
| RGS7, partial | Homo sapiens (human) | EC50 | 30.0000 | 1 | 1 |
| troponin C, slow skeletal and cardiac muscles | Homo sapiens (human) | EC50 | 71.3750 | 1 | 1 |
| troponin I, cardiac muscle | Homo sapiens (human) | EC50 | 71.3750 | 1 | 1 |
| troponin T, cardiac muscle isoform 3 | Homo sapiens (human) | EC50 | 71.3750 | 1 | 1 |