Purpura Fulminans

A severe, rapidly fatal reaction occurring most commonly in children following an infectious illness. It is characterized by large, rapidly spreading skin hemorrhages, fever, or shock. Purpura fulminans often accompanies or is triggered by DISSEMINATED INTRAVASCULAR COAGULATION.

Synonym
Purpura Fulminans

Excerpt	Reference
"Sepsis-induced purpura fulminans is a rare but life-threatening condition characterized by rapidly progressive hemorrhagic infarction of the skin due to dermal vascular thrombosis resulting in tissue loss and severe scarring."	( Fitzgerald, CJ; Givner, LB; Mou, S; Pranikoff, TV; Ross, GA; Shetty, AK, 2012)
"Purpura fulminans is an acute life-threatening disorder characterized by intravascular thrombosis and hemorrhagic infarction of the skin complicated with disseminated intravascular coagulation."	( Dalugama, C; Gawarammana, IB, 2018)
"Purpura fulminans is a severe and rapidly progressive septic process characterised by the development of haemorrhagic and ecchymotic lesions and skin necrosis."	( Bosch-Alcaraz, A; Manzano-Canillas, ML; Pérez-Acevedo, G; Torra-Bou, JE, 2019)
"Purpura fulminans is a rare complication and manifestation of disseminated intravascular coagulation and sepsis."	( Djurdjevic, N; Dumic, I; LaNou, A; McDermott, WR; Patel, JN; Paulson, M; Radovanovic, M; Taweesedt, PT; Veselinovic, M, 2020)
"Acute infectious purpura fulminans is a serious, potentially fatal condition."	( Abdul Kalam, S; Abraham, OC; Antony, J; Carey, RA, 2020)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	12 (22.22)	23.3326
1990's	0 (0.00)	12.5806
2000's	9 (16.67)	18.1394
2010's	28 (51.85)	28.8240
2020's	5 (9.26)	9.53

Drug	Relationship Strength	Studies
dalteparin	low	3
acetazolamide	low	1
citalopram	low	1
milrinone	low	2
pentoxifylline	low	1
promethazine	low	2
prednisolone	low	2
prednisone	low	6
chloramphenicol	low	1
methylprednisolone	low	2
penicillanic acid	low	1
thiazoles	low	1
vancomycin	low	2
trolamine salicylate	low	1
levamisole	low	2
4-methoxyamphetamine	low	1
amoxicillin	low	1
piperacillin	low	1
octenidine	low	1
cephalosporin c	low	1
fibrinogen	low	2
artesunic acid	low	2
cortisone	low	4
trimethoprim, sulfamethoxazole drug combination	low	1
fibrin	low	1
epiglucan	low	1
inositol 3-phosphate	low	1
clindamycin	low	1
micafungin	low	1
propylthiouracil	low	1
quinine	low	1
vitamin k semiquinone radical	low	1
codeine	low	1
phenylephrine hydrochloride	low	4
rivaroxaban	low	1
edoxaban	low	1
pituitrin	low	1
ro13-9904	low	9
piperacillin, tazobactam drug combination	low	1
ascorbic acid	low	2
tetracycline	low	2
warfarin	low	3
chondroitin sulfates	low	1
acyclovir	low	1

Protein Targets (616)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
5-hydroxytryptamine receptor 2C	0	2	1	3
5-hydroxytryptamine receptor 2A	0	2	1	3
5-hydroxytryptamine receptor 1A	0	4	1	5
5-hydroxytryptamine receptor 1B	0	3	1	4
5-hydroxytryptamine receptor 1D	0	1	1	2
5-hydroxytryptamine receptor 1F	0	1	1	2
5-hydroxytryptamine receptor 2B	0	2	1	3
5-hydroxytryptamine receptor 6	0	0	1	1
Sodium-dependent serotonin transporter	0	4	2	6
Sodium-dependent serotonin transporter	0	4	0	4
5-hydroxytryptamine receptor 7	0	0	1	1
5-hydroxytryptamine receptor 5A	0	0	1	1
5-hydroxytryptamine receptor 5B	0	0	1	1
5-hydroxytryptamine receptor 3A	0	0	1	1
5-hydroxytryptamine receptor 4	0	0	1	1
5-hydroxytryptamine receptor 3B	0	0	1	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	2	0	0	2
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Beta-lactamase	5	0	0	5
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Class Iii Chitinase Chia1	0	1	0	1
Chain A, Carbonic anhydrase 13	0	1	0	1
Chain A, Carbonic anhydrase II	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase	0	1	0	1
Chain B, Carbonic anhydrase	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	1	0	1
thioredoxin reductase	12	0	0	12
GALC protein	2	0	0	2
GLI family zinc finger 3	13	0	0	13
nuclear receptor subfamily 1, group I, member 3	3	0	0	3
cytochrome P450 family 3 subfamily A polypeptide 4	6	0	0	6
glucocorticoid receptor [Homo sapiens]	11	0	0	11
retinoic acid nuclear receptor alpha variant 1	10	0	0	10
retinoid X nuclear receptor alpha	5	0	0	5
estrogen-related nuclear receptor alpha	10	0	0	10
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
arylsulfatase A	4	0	0	4
Carbonic anhydrase	0	1	0	1
euchromatic histone-lysine N-methyltransferase 2	13	0	0	13
Bloom syndrome protein isoform 1	4	0	0	4
thyroid hormone receptor beta isoform a	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 1	10	0	0	10
geminin	10	0	0	10
peripheral myelin protein 22	5	0	0	5
survival motor neuron protein isoform d	4	0	0	4
muscleblind-like protein 1 isoform 1	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	1	1	0	2
ATP-binding cassette sub-family C member 3	0	14	0	14
Multidrug resistance-associated protein 4	0	14	0	14
Carbonic anhydrase	0	1	0	1
Solute carrier family 22 member 6	0	1	0	2
Carbonic anhydrase 12	0	2	1	5
Prolyl endopeptidase	0	1	0	1
Carbonic anhydrase-related protein 11	0	1	0	2
Bile salt export pump	0	19	0	19
Glycogen phosphorylase, muscle form	0	1	0	1
Renin	0	2	0	2
Carbonic anhydrase 1	0	2	1	7
Carbonic anhydrase 2	0	2	1	6
Carbonic anhydrase 2	0	2	0	2
Cytochrome P450 1A2	0	1	0	1
Carbonic anhydrase 3	0	2	1	5
Cathepsin B	0	1	0	1
Cytochrome P450 3A4	0	2	0	2
Steryl-sulfatase	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Cytochrome P450 2C8	0	1	0	1
Cytochrome P450 2D6	0	4	0	4
Cytochrome P450 2A6	0	1	0	1
Cytochrome P450 2C9	0	5	0	5
Androgen receptor	0	4	0	4
Gamma-aminobutyric acid receptor subunit beta-1	1	1	0	2
Translocator protein	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	1	1	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	1	1	0	2
Gamma-aminobutyric acid receptor subunit alpha-5	1	1	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	1	1	0	2
Cannabinoid receptor 1	0	1	0	1
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
Cytochrome P450 2B6	0	1	0	1
Carbonic anhydrase 4	0	2	1	4
Carbonic anhydrase 6	0	2	1	4
Gamma-aminobutyric acid receptor subunit gamma-1	1	1	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	1	1	0	2
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Adenosine receptor A1	0	1	0	1
Serum paraoxonase/arylesterase 1	0	1	0	1
Dipeptidyl peptidase 4	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	1	1	0	2
Gamma-aminobutyric acid receptor subunit gamma-3	1	1	0	2
Endochitinase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	1	1	0	2
Adenosine receptor A2a	0	1	0	1
Delta-type opioid receptor	0	2	0	2
Cytochrome P450 2C19	0	1	0	1
Delta-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	2	1	5
Carbonic anhydrase	0	1	0	1
Kappa-type opioid receptor	0	1	0	3
Carbonic anhydrase 7	0	2	1	4
Carbonic anhydrase	0	1	0	1
D(1A) dopamine receptor	1	1	0	2
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Carbonic anhydrase	0	1	0	1
D(2) dopamine receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	1	1	0	2
Gamma-aminobutyric acid receptor subunit beta-3	1	1	0	2
Gamma-aminobutyric acid receptor subunit beta-2	1	1	0	2
Cholinesterase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Fatty-acid amide hydrolase 1	0	2	0	2
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Squalene synthase	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Carbonic anhydrase 9	0	2	1	5
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 3	0	1	0	1
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase	0	1	0	1
Sigma intracellular receptor 2	0	2	0	2
Delta carbonic anhydrase	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	1	0	1
Renin	0	1	0	1
Carbonic anhydrase	0	1	0	1
Endochitinase A1	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Carbonic anhydrase 13	0	2	1	4
GABA theta subunit	1	1	0	2
Canalicular multispecific organic anion transporter 1	0	13	0	13
Carbonic anhydrase 4	0	2	0	2
Carbonic anhydrase 15	0	1	0	2
Acidic mammalian chitinase	0	1	0	1
Carbonic anhydrase 13	0	2	0	3
Carbonic anhydrase 7	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	1	1	0	2
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 14	0	2	1	5
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 2, isoform A	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	2	1	5
Chain E, Purine nucleoside phosphorylase	0	1	0	1
Chain A, HADH2 protein	4	0	0	4
Chain B, HADH2 protein	4	0	0	4
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
Chain A, Ferritin light chain	2	0	0	2
Thymidine kinase	0	1	0	1
phosphopantetheinyl transferase	3	0	0	3
GLS protein	3	0	0	3
TDP1 protein	11	0	0	11
Smad3	1	0	0	1
thyroid stimulating hormone receptor	4	0	0	4
EWS/FLI fusion protein	8	0	0	8
activating transcription factor 6	3	0	0	3
Histone H2A.x	2	0	0	2
hemoglobin subunit beta	1	0	0	1
atrial natriuretic peptide receptor 1 precursor	3	0	0	3
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
lamin isoform A-delta10	7	0	0	7
Solute carrier family 22 member 1	0	5	0	6
Bile salt export pump	0	3	0	3
Purine nucleoside phosphorylase	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	1
POU domain, class 2, transcription factor 2	0	0	0	1
Cytochrome P450 2J2	0	3	0	3
Disintegrin and metalloproteinase domain-containing protein 17	2	0	0	2
Purine nucleoside phosphorylase	0	0	1	1
Solute carrier family 22 member 6	0	0	0	1
Thymidine kinase	0	1	0	1
Solute carrier family 22 member 8	0	0	0	2
Thymidine kinase	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	3	0	0	3
Chain A, 2-oxoglutarate Oxygenase	5	0	0	5
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
AR protein	11	0	0	11
apical membrane antigen 1, AMA1	1	0	0	1
estrogen nuclear receptor alpha	14	0	0	14
Beta-lactamase	0	0	0	2
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	3	0	0	3
DNA polymerase eta isoform 1	1	0	0	1
DNA polymerase iota isoform a (long)	4	0	0	4
urokinase-type plasminogen activator precursor	1	0	0	1
plasminogen precursor	1	0	0	1
urokinase plasminogen activator surface receptor precursor	1	0	0	1
DNA polymerase kappa isoform 1	1	0	0	1
Beta-lactamase SHV-1	0	0	0	2
Beta-lactamase SHV-1	0	0	0	2
Beta-lactamase	0	0	0	2
Solute carrier family 15 member 1	0	2	0	2
Solute carrier family 15 member 1	0	1	0	1
B2 metallo-beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Solute carrier family 15 member 2	0	1	0	1
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Chain A, Hyaluronidase, phage associated	0	1	0	1
acetylcholinesterase	4	0	0	4
RAR-related orphan receptor gamma	8	0	0	8
thioredoxin glutathione reductase	3	0	0	3
vitamin D (1,25- dihydroxyvitamin D3) receptor	7	0	0	7
IDH1	3	0	0	3
chromobox protein homolog 1	7	0	0	7
nuclear factor erythroid 2-related factor 2 isoform 2	4	0	0	4
thyroid hormone receptor beta isoform 2	7	0	0	7
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
lethal factor (plasmid)	2	0	0	2
Polyphenol oxidase 2	0	1	0	1
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	1	0	1
Urease	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	1	0	1
Alpha-2B adrenergic receptor	0	2	1	3
Spike glycoprotein	6	1	1	8
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
interleukin 8	2	0	0	2
aldehyde dehydrogenase 1 family, member A1	6	0	0	6
farnesoid X nuclear receptor	2	0	0	2
pregnane X nuclear receptor	8	0	0	8
G	3	0	0	3
cytochrome P450 2D6	5	0	0	5
peroxisome proliferator activated receptor gamma	8	0	0	8
aryl hydrocarbon receptor	4	0	0	4
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	4	0	0	4
heat shock protein beta-1	2	0	0	2
streptokinase A precursor	0	0	2	2
Dihydroxyacetone phosphate acyltransferase	0	0	0	2
Interferon beta	5	0	0	5
HLA class I histocompatibility antigen, B alpha chain	3	0	0	3
30S ribosomal protein S6	0	2	0	2
30S ribosomal protein S7	0	2	0	2
50S ribosomal protein L15	0	2	0	2
Cellular tumor antigen p53	7	0	0	7
50S ribosomal protein L10	0	2	0	2
50S ribosomal protein L11	0	2	0	2
50S ribosomal protein L7/L12	0	2	0	2
50S ribosomal protein L19	0	2	0	2
50S ribosomal protein L1	0	2	0	2
50S ribosomal protein L20	0	2	0	2
50S ribosomal protein L27	0	2	0	2
50S ribosomal protein L28	0	2	0	2
50S ribosomal protein L29	0	2	0	2
50S ribosomal protein L31	0	2	0	2
50S ribosomal protein L31 type B	0	2	0	2
50S ribosomal protein L32	0	2	0	2
50S ribosomal protein L33	0	2	0	2
50S ribosomal protein L34	0	2	0	2
50S ribosomal protein L35	0	2	0	2
50S ribosomal protein L36	0	2	0	2
30S ribosomal protein S10	0	2	0	2
30S ribosomal protein S11	0	2	0	2
30S ribosomal protein S12	0	2	0	2
30S ribosomal protein S13	0	2	0	2
30S ribosomal protein S16	0	2	0	2
30S ribosomal protein S18	0	2	0	2
30S ribosomal protein S19	0	2	0	2
30S ribosomal protein S20	0	2	0	2
30S ribosomal protein S2	0	2	0	2
30S ribosomal protein S3	0	2	0	2
30S ribosomal protein S4	0	2	0	2
30S ribosomal protein S5	0	2	0	2
30S ribosomal protein S8	0	2	0	2
30S ribosomal protein S9	0	2	0	2
50S ribosomal protein L13	0	2	0	2
50S ribosomal protein L14	0	2	0	2
50S ribosomal protein L16	0	2	0	2
50S ribosomal protein L23	0	2	0	2
30S ribosomal protein S15	0	2	0	2
50S ribosomal protein L17	0	2	0	2
50S ribosomal protein L21	0	2	0	2
50S ribosomal protein L30	0	2	0	2
50S ribosomal protein L6	0	2	0	2
30S ribosomal protein S14	0	2	0	2
30S ribosomal protein S17	0	2	0	2
30S ribosomal protein S1	0	2	0	2
50S ribosomal protein L18	0	2	0	2
50S ribosomal protein L2	0	2	0	2
50S ribosomal protein L3	0	2	0	2
50S ribosomal protein L24	0	2	0	2
50S ribosomal protein L4	0	2	0	2
50S ribosomal protein L22	0	2	0	2
50S ribosomal protein L5	0	2	0	2
30S ribosomal protein S21	0	2	0	2
50S ribosomal protein L25	0	2	0	2
50S ribosomal protein L36 2	0	2	0	2
Inositol hexakisphosphate kinase 1	3	0	0	3
Methionine--tRNA ligase, mitochondrial	0	0	1	1
cytochrome P450 2C9, partial	3	0	0	3
NPC intracellular cholesterol transporter 1 precursor	2	0	0	2
D(1A) dopamine receptor	2	0	0	2
Sodium-dependent noradrenaline transporter	0	1	0	1
5-hydroxytryptamine receptor 4	0	4	0	4
Aldo-keto reductase family 1 member B1	0	4	0	4
Tryptophan 5-hydroxylase 1	0	1	0	1
Angiotensin-converting enzyme	0	2	0	2
Aldo-keto reductase family 1 member B1	0	1	0	1
Acetylcholinesterase	0	2	0	2
Aromatase	0	1	0	1
Sodium-dependent noradrenaline transporter	0	4	0	4
Sodium-dependent dopamine transporter	0	1	0	1
Alpha-1D adrenergic receptor	0	4	0	4
5-hydroxytryptamine receptor 2C	0	4	0	4
Histamine H1 receptor	0	4	0	4
5-hydroxytryptamine receptor 2B	0	4	0	4
5-hydroxytryptamine receptor 7	0	3	0	3
Sodium-dependent dopamine transporter	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	5	0	5
Sodium-dependent serotonin transporter	0	1	0	1
Sodium-dependent dopamine transporter	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Ataxin-2	6	0	0	6
Sigma non-opioid intracellular receptor 1	0	4	0	4
Sigma non-opioid intracellular receptor 1	0	1	0	1
Transporter	0	3	0	3
ATP-dependent phosphofructokinase	5	0	0	5
Protein-arginine deiminase type-4	0	2	0	2
Cytochrome P450 2D1	0	2	0	2
Cytochrome P450 2D26	0	2	0	2
Cytochrome P450 2D3	0	2	0	2
UDP-glucuronosyltransferase 2B7	0	0	0	1
Kappa-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	2	1	3
Delta-type opioid receptor	0	2	0	2
Kappa-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	1	0	1
Cytochrome P450 2D4	0	2	0	2
Mas-related G-protein coupled receptor member X2	0	0	1	1
endonuclease IV	2	0	0	2
dopamine D1 receptor	3	0	0	3
pregnane X receptor	2	0	0	2
progesterone receptor	7	0	0	7
regulator of G-protein signaling 4	4	0	0	4
peroxisome proliferator-activated receptor delta	3	0	0	3
v-jun sarcoma virus 17 oncogene homolog (avian)	4	0	0	4
peripheral myelin protein 22 isoform 1	2	0	0	2
flap endonuclease 1	2	0	0	2
cytochrome P450 3A4 isoform 1	1	0	0	1
M-phase phosphoprotein 8	2	0	0	2
muscarinic acetylcholine receptor M1	3	0	0	3
Glucocorticoid receptor	0	8	2	15
Sex hormone-binding globulin	0	0	1	1
Glycine receptor subunit alpha-1	0	8	0	8
Corticosteroid-binding globulin	0	2	0	2
Glycine receptor subunit beta	0	8	0	8
Glycine receptor subunit alpha-2	0	8	0	8
Glycine receptor subunit alpha-3	0	8	0	8
Potassium voltage-gated channel subfamily A member 1	0	0	1	1
TAR DNA-binding protein 43	1	0	0	1
Multidrug and toxin extrusion protein 1	0	2	0	2
Coagulation factor X	0	4	0	4
Luciferase	2	0	0	2
ras-related protein Rab-9A	1	0	0	1
Fatty acid-binding protein, liver	0	2	0	2
Albumin	0	1	3	4
Fatty acid-binding protein, intestinal	0	1	1	2
Prostaglandin G/H synthase 1	0	2	0	2
Caspase-1	0	1	0	1
Prostaglandin G/H synthase 2	0	2	0	2
Caspase-3	0	1	0	1
Caspase-4	0	1	0	1
Caspase-5	0	1	0	1
Caspase-9	0	1	0	1
Cell division control protein 42 homolog	0	1	0	1
Ras-related C3 botulinum toxin substrate 1	0	1	0	1
Serine/threonine-protein kinase PAK 1	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	2	0	2
Alkaline phosphatase, placental type	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	2	0	2
Intestinal-type alkaline phosphatase	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
5'-nucleotidase	0	1	0	1
Phospholipase A-2-activating protein	0	1	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	1	0	0	1
Replicase polyprotein 1ab	0	2	1	3
CAAX prenyl protease 2 isoform 2	0	0	0	1
DNA polymerase beta	1	0	0	1
histone acetyltransferase KAT2A isoform 1	3	0	0	3
Tubulin beta-4A chain	0	1	0	1
Tubulin beta chain	0	1	0	1
ATP-dependent translocase ABCB1	0	2	0	4
Tubulin alpha-3C chain	0	1	0	1
Tubulin alpha-1B chain	0	1	0	1
Tubulin alpha-4A chain	0	1	0	1
Tubulin beta-4B chain	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA primase	0	1	0	1
Tubulin beta-3 chain	0	1	0	1
Tubulin beta-2A chain	0	1	0	1
Tubulin beta-8 chain	0	1	0	1
Tubulin alpha-3E chain	0	1	0	1
Tubulin alpha-1A chain	0	1	0	1
Tubulin alpha-1C chain	0	1	0	1
Tubulin beta-6 chain	0	1	0	1
Tubulin beta-2B chain	0	1	0	1
Tubulin beta-1 chain	0	1	0	1
hypoxia-inducible factor 1 alpha subunit	2	0	0	2
PPM1D protein	2	0	0	2
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	3	0	0	3
nonstructural protein 1	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	1	0	0	1
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	3	0	0	3
nuclear receptor subfamily 1, group I, member 2	2	0	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
ATPase family AAA domain-containing protein 5	3	0	0	3
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	1
glp-1 receptor, partial	2	0	0	2
SMAD family member 2	1	0	0	1
SMAD family member 3	1	0	0	1
Phosphodiesterase	0	1	0	1
thyroid stimulating hormone receptor	3	0	0	3
cytochrome P450 2C19 precursor	2	0	0	2
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	1	0	0	1
Vpr	2	0	0	2
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	2	0	2
Aurora kinase A	0	1	0	1
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	0	2	0	2
cGMP-specific 3',5'-cyclic phosphodiesterase	0	2	0	2
3',5'-cyclic-AMP phosphodiesterase	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	2	0	2
Dual specificity protein kinase TTK	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	2	0	2
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	2	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	3	0	3
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Aurora kinase B	0	1	0	1
Inner centromere protein	0	1	0	1
Phosphodiesterase	0	1	0	1
ATAD5 protein, partial	1	0	0	1
NFKB1 protein, partial	1	0	0	1
vasopressin V1b receptor	1	0	0	1
relaxin receptor 1 isoform 1	1	0	0	1
Tumor necrosis factor	0	1	0	1
Cholinesterase	0	1	0	1
Adenosine receptor A2b	0	1	0	1
Inositol monophosphatase 1	2	0	0	2
Chitotriosidase-1	0	2	1	3
Endochitinase B1	0	2	1	3
beta-2 adrenergic receptor	1	0	0	1
lysosomal alpha-glucosidase preproprotein	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Neuronal acetylcholine receptor subunit alpha-4	1	0	0	1
Neuronal acetylcholine receptor subunit beta-2	1	0	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase type 2	0	0	0	1
Metallo-beta-lactamase VIM-19	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Beta-lactamase OXA-7	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Metallo-beta-lactamase VIM-13	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Class D beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-b-lactamase	0	0	0	1
BlaVIM-1	0	0	0	1
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	1
Histamine H3 receptor	0	0	0	1
Beta-lactamase class B VIM-2	0	0	0	1
Beta-lactamase VIM-1	0	0	0	1
luciferase	0	0	0	1
Voltage-dependent calcium channel gamma-2 subunit	1	0	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	2	0	2
Glutamine synthetase	0	0	1	1
Glutamate receptor 2	1	0	0	1
Histamine H1 receptor	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
estrogen receptor 2 (ER beta)	2	0	0	2
vitamin D3 receptor isoform VDRA	3	0	0	3
nuclear receptor ROR-gamma isoform 1	1	0	0	1
Nuclear receptor ROR-gamma	1	0	0	1
glucocerebrosidase	1	0	0	1
Snq2p	0	0	0	1
Spike glycoprotein	0	1	1	2
potassium voltage-gated channel subfamily H member 2 isoform d	1	0	0	1
huntingtin isoform 2	1	0	0	1
serine/threonine-protein kinase mTOR isoform 1	1	0	0	1
Transmembrane protease serine 2	0	1	1	2
Major prion protein	0	0	1	1
Procathepsin L	0	1	1	2
Muscarinic acetylcholine receptor M2	0	3	0	3
Muscarinic acetylcholine receptor M4	0	2	0	2
Muscarinic acetylcholine receptor M5	0	2	0	2
Alpha-2A adrenergic receptor	0	3	0	3
Replicase polyprotein 1a	0	1	1	2
Replicase polyprotein 1ab	0	1	1	2
Replicase polyprotein 1ab	0	1	1	2
Calmodulin-1	0	1	0	1
Replicase polyprotein 1ab	0	1	1	2
Muscarinic acetylcholine receptor M1	0	2	0	2
D(2) dopamine receptor	0	2	0	2
Alpha-2C adrenergic receptor	0	2	0	2
Muscarinic acetylcholine receptor M3	0	2	0	2
D(1A) dopamine receptor	0	2	0	2
Histamine H2 receptor	0	2	0	2
5-hydroxytryptamine receptor 2A	0	2	0	2
Trypanothione reductase	0	2	0	2
Pleiotropic ABC efflux transporter of multiple drugs	0	1	0	2
D(3) dopamine receptor	0	2	0	2
5-hydroxytryptamine receptor 6	0	2	0	2
Calmodulin	0	0	1	1
Voltage-dependent N-type calcium channel subunit alpha-1B	0	1	0	1
Angiotensin-converting enzyme 2	0	1	1	2
Chloroquine resistance transporter	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	2	0	0	2
NADH-cytochrome b5 reductase 3	0	1	0	1
Myeloperoxidase	0	1	0	1
Thyroid peroxidase	0	1	0	1
Taste receptor type 2 member 38	0	0	1	2
Solute carrier family 22 member 1	0	1	0	1
Solute carrier family 22 member 2	0	1	0	2
Solute carrier organic anion transporter family member 1A4	0	1	0	1
Solute carrier family 22 member 2	0	1	0	1
Potassium channel subfamily K member 2	0	1	0	1
Histidine-rich protein PFHRP-II	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	1
Solute carrier family 22 member 1	0	2	0	3
Solute carrier family 22 member 2	0	2	0	2
Chain A, Activated Factor Xa Heavy Chain	0	1	0	1
Prothrombin	0	1	0	1
Coagulation factor XII	0	1	0	1
Suppressor of tumorigenicity 14 protein	0	1	0	1
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
estrogen receptor beta isoform 1	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	1	0	1
tyrosine-protein phosphatase non-receptor type 7 isoform 2	0	1	0	1
Tetracycline resistance protein, class B	0	0	0	1
72 kDa type IV collagenase	0	1	0	1
Stromelysin-1	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
Alpha-1B adrenergic receptor	0	2	0	2
Neutrophil collagenase	0	1	0	1
Alpha-1D adrenergic receptor	0	2	0	2
Alpha-synuclein	0	1	0	1
Alpha-1A adrenergic receptor	0	2	0	2
Collagenase 3	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
Integrase	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Solute carrier family 22 member 11	0	0	0	1
Solute carrier family 22 member 7	0	0	0	1
60 kDa heat shock protein, mitochondrial	0	1	0	1
Alpha-2B adrenergic receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
10 kDa heat shock protein, mitochondrial	0	1	0	1
D-alanyl-D-alanine dipeptidase	0	1	0	1
Thiosulfate sulfurtransferase	0	1	0	1
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
USP1 protein, partial	1	0	0	1
Rap guanine nucleotide exchange factor 3	1	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
Albumin	0	0	1	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Protease	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Research

Studies (54)

Protein Targets (616)

Purpura Fulminans

Synonyms(1)

Research Excerpts

Overview

Research

Studies (54)

Drugs Studied (50)

Protein Targets (616)