A substance which is structurally similar to a metabolite but which competes with it or replaces it, and so prevents or reduces its normal utilization.
| Member | Definition | Class |
|---|
| 10-propargyl-10-deazaaminopterin | A pteridine that is the N-4-[1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl]benzoyl derivative of L-glutamic acid. Used for treatment of Peripheral T-Cell Lymphoma, an aggressive form of non-Hodgkins lymphoma. | pralatrexate |
| 2-aminopurine | The parent compound of the 2-aminopurines, comprising a purine core carrying an amino substituent at the 2-position. | 2-aminopurine |
| 3'-deoxyadenosine 5'-triphosphate | | cordycepin triphosphate |
| 5-iodouracil | An organoiodine compound consisting of uracil having an iodo substituent at the 5-position. | 5-iodouracil |
| 6-aminonicotinamide | A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 6-aminonicotinic acid with ammonia. An inhibitor of the NADP(+)-dependent enzyme, 6-phosphogluconate dehydrogenase, it interferes with glycolysis, resulting in ATP depletion and synergizes with DNA-crosslinking chemotherapy drugs, such as cisplatin, in killing cancer cells. | 6-aminonicotinamide |
| acivicin | An L-alpha-amino acid that is L-alanine in which the methyl group is replaced by a (5S)-3-chloro-4,5-dihydro-1,2-oxazol-5-yl group. A glutamine analogue antimetabolite, it interferes with glutamate metabolism and several glutamate-dependent synthetic enzymes. It is obtained as a fermentation product of Streptomyces sviceus bacteria. | acivicin |
| acyclovir | An oxopurine that is guanine substituted by a (2-hydroxyethoxy)methyl substituent at position 9. Used in the treatment of viral infections. | acyclovir |
| allopurinol | A bicyclic structure comprising a pyrazole ring fused to a hydroxy-substituted pyrimidine ring. | allopurinol |
| ancitabine | An organic heterotricyclic compound resulting from the formal condensation of the oxo group of cytidine to the 2' position with loss of water to give the corresponding cyclic ether. A prodrug, it is metabolised to the antineoplastic agent cytarabine, so is used to maintain a more constant antineoplastic action. | ancitabine |
| anticapsin | An L-alpha-amino acid zwitterion obtained by transfer of a proton from the carboxy to the amino group of anticapsin; major species at pH 7.3. | anticapsin zwitterion; anticapsin |
| anticapsin | An alanine derivative that is L-alanine bearing a 5-oxo-7-oxabicyclo[4.1.0]hept-2-yl substituent at position 3. | anticapsin zwitterion; anticapsin |
| azaguanine | A triazolopyrimidine that consists of 3,6-dihydro-7H-[1,2,3]triazolo[4,5-d]pyrimidine bearing amino and oxo substituents at positions 5 and 7 respectively. | 8-azaguanine |
| azaserine | A carboxylic ester resulting from the formal condensation of the carboxy group of diazoacetic acid with the alcoholic hydroxy group of L-serine. An antibiotic produced by a Streptomyces species. | azaserine |
| azathioprine | A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS. | azathioprine |
| azauracil | A 1,2,4-triazine compound having oxo-substituents at the 3- and 5-positions. | 6-azauracil |
| azauridine | | 6-azauridine |
| brequinar | A quinolinemonocarboxylic acid that is quinoline substituted by 2'-fluoro[1,1'-biphenyl]-4-yl, methyl, carboxy and fluoro groups at positions 2, 3, 4, and 6, respectively. It is an inhibitor of dihydroorotate dehydrogenase, an enzyme that is required for de novo pyrimidine biosynthesis. The compound exhibits antineoplastic and antiviral properties. | brequinar |
| brequinar sodium | An organic sodium salt of brequinar. | brequinar sodium |
| bromodeoxyuridine | A pyrimidine 2'-deoxyribonucleoside compound having 5-bromouracil as the nucleobase. | 5-bromo-2'-deoxyuridine |
| canaline | A non-proteinogenic L-alpha-amino acid that is L-homoserine in which the hydroxy group at position 4 is substituted by an aminooxy group. It has been isolated from legumes and plays an essential role in lugume chemical defense against insects. | L-canaline zwitterion; L-canaline |
| capecitabine | A carbamate ester that is cytidine in which the hydrogen at position 5 is replaced by fluorine and in which the amino group attached to position 4 is converted into its N-(penyloxy)carbonyl derivative. Capecitabine is a antineoplastic agent used in the treatment of cancers. | capecitabine |
| cerulenin | An epoxydodecadienamide isolated from several species, including Acremonium, Acrocylindrum and Helicoceras. It inhibits the biosynthesis of several lipids by interfering with enzyme function. | cerulenin |
| clofarabine | A purine nucleoside analogue consisting of a 6-amino-2-chloropurin-9-yl group attached to the 1beta position of 2'-deoxy-2'-fluoro-D-arabinofuranose. It is metabolized intracellularly to the active 5'-triphosphate metabolite, which inhibits DNA synthesisis and so stops the growth of cancer cells. Clofarabine is used as an antimetabolite antineoplastic agent in the treatment of relapsed or refractory acute lymphoblastic leukaemia. | clofarabine |
| cordycepin | | cordycepin |
| cyc 682 | A nucleoside analogue resulting from the formal condensation of the carboxy group of hexadecanoic acid with the amino group of CNDAC. It is the prodrug of CNDAC and is currently in clinical development for the treatment of acute myeloid leukemia (AML). | sapacitabine |
| cycloserine | A 4-amino-1,2-oxazolidin-3-one that has R configuration. It is an antibiotic produced by Streptomyces garyphalus or S. orchidaceus and is used as part of a multi-drug regimen for the treatment of tuberculosis when resistance to, or toxicity from, primary drugs has developed. An analogue of D-alanine, it interferes with bacterial cell wall synthesis in the cytoplasm by competitive inhibition of L-alanine racemase (which forms D-alanine from L-alanine) and D-alanine--D-alanine ligase (which incorporates D-alanine into the pentapeptide required for peptidoglycan formation and bacterial cell wall synthesis). | D-cycloserine zwitterion; D-cycloserine |
| cytarabine | A pyrimidine nucleoside in which cytosine is attached to D-arabinofuranose via a beta-N(1)-glycosidic bond. Used mainly in the treatment of leukaemia, especially acute non-lymphoblastic leukaemia, cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. It also has antiviral and immunosuppressant properties. | cytarabine |
| diazooxonorleucine | A non-proteinogenic L-alpha-amino acid that is L-norleucine which is substituted at position 5 by an oxo group and at position 6 by a diazo group. It is as inhibitor of various glutamine-utilising enzymes. | 6-diazo-5-oxo-L-norleucine zwitterion; 6-diazo-5-oxo-L-norleucine |
| didanosine | A purine 2',3'-dideoxyribonucleoside that is inosine in which the hydroxy groups at both the 2' and the 3' positions on the sugar moiety have been replaced by hydrogen. An antiviral drug, it is used as a medication to treat HIV/AIDS. | didanosine |
| doxifluridine | A pyrimidine 5'-deoxyribonucleoside that is 5-fluorouridine in which the hydroxy group at the 5' position is replaced by a hydrogen. It is an oral prodrug of the antineoplastic agent 5-fluorouracil. Designed to circumvent the rapid degradation of 5-fluorouracil by dihydropyrimidine dehydrogenase in the gut wall, it is converted into 5-fluorouracil in the presence of pyrimidine nucleoside phosphorylase. | doxifluridine |
| ethionine | An S-ethylhomocysteine that has S-configuration at the chiral centre. | L-ethionine |
| ezetimibe | A beta-lactam that is azetidin-2-one which is substituted at 1, 3, and 4 by p-fluorophenyl, 3-(p-fluorophenyl)-3-hydroxypropyl, and 4-hydroxyphenyl groups, respectively (the 3R,3'S,4S enantiomer). | ezetimibe |
| floxuridine | A pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract. | floxuridine |
| fludarabine phosphate | A purine arabinonucleoside monophosphate having 2-fluoroadenine as the nucleobase. A prodrug, it is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. Once incorporated into DNA, 2-fluoro-ara-ATP functions as a DNA chain terminator. It is used for the treatment of adult patients with B-cell chronic lymphocytic leukemia (CLL) who have not responded to, or whose disease has progressed during, treatment with at least one standard alkylating-agent containing regimenas. | fludarabine phosphate |
| fluorouracil | A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth. | 5-fluorouracil |
| gemcitabine | A 2'-deoxycytidine having geminal fluoro substituents in the 2'-position. An inhibitor of ribonucleotide reductase, gemcitabine is used in the treatment of various carcinomas, particularly non-small cell lung cancer, pancreatic cancer, bladder cancer and breast cancer. | gemcitabine |
| gemcitabine hydrochloride | A 2'-deoxycytidine hydrochloriode having geminal fluoro substituents in the 2'-position. An inhibitor of ribonucleotide reductase, gemcitabine hydrochloride is used in the treatment of various carcinomas, including non-small cell lung cancer, pancreatic cancer, bladder cancer and breast cancer. | gemcitabine hydrochloride |
| hydroxyurea | A member of the class of ureas that is urea in which one of the hydrogens is replaced by a hydroxy group. An antineoplastic used in the treatment of chronic myeloid leukaemia as well as for sickle-cell disease. | hydroxyurea |
| i-677 | An L-alpha-amino acid that is L-serine in which the hydroxy group at position 3 is converted to the corresponding 2-aminoethyl ether. An antimetabolic antibiotic obtained from Streptomyces reseoviridofuscus. | O-(2-aminoethyl)-L-serine |
| meglutol | A dicarboxylic acid that is glutaric acid in which one of the two hydrogens at position 3 is substituted by a hydroxy group, while the other is substituted by a methyl group. It has been found to accumulate in urine of patients suffering from HMG-CoA lyase (3-hydroxy-3-methylglutaryl-CoA lyase, EC 4.1.3.4) deficiency. It occurs as a plant metabolite in Crotalaria dura. | 3-hydroxy-3-methylglutaric acid |
| mercaptopurine | A thiol that is the tautomer of mercaptopurine. | 3,7-dihydropurine-6-thione; mercaptopurine; purine-6-thiol |
| mercaptopurine | A member of the class of purines that is 6,7-dihydro-1H-purine carrying a thione group at position 6. An adenine analogue, it is used in the treatment of acute lymphocytic leukemia (ALL), chronic myeloid leukemia (CML), Crohn's disease, and ulcerative colitis. | 3,7-dihydropurine-6-thione; mercaptopurine; purine-6-thiol |
| methotrexate | | methotrexate |
| metyrapone | An aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency. | metyrapone |
| nsc-145,668 | A hydrochloride salt resulting from the reaction of equimolar amounts of ancitabine and hydrogen chloride. | ancitabine hydrochloride |
| oxythiamine | A 1,3-thiazolium cation that is 5-(2-hydroxyethyl)-4-methyl-1,3-thiazole alkylated at the N3 position by a (2-methyl-4-oxo-1,4-dihydropyrimidin-5-yl)methyl group. | oxythiamine(1+) |
| pemetrexed | An N-acylglutamic acid in which the N-acyl group is specified as 4-[2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl. Inhibits thymidylate synthase (TS), 421 dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT). | pemetrexed |
| pentostatin | A member of the class of coformycins that is coformycin in which the hydroxy group at position 2' is replaced with a hydrogen. It is a drug used for the treatment of hairy cell leukaemia. | pentostatin |
| propylthiouracil | A pyrimidinethione consisting of uracil in which the 2-oxo group is substituted by a thio group and the hydrogen at position 6 is substituted by a propyl group. | 6-propyl-2-thiouracil |
| pyrazofurin | A C-glycosyl compound that is 4-hydroxy-1H-pyrazole-5-carboxamide in which the hydrogen at position 3 has been replaced by a beta-D-ribofuranosyl group. | pirazofurin |
| ribavirin | A 1-ribosyltriazole that is the 1-ribofuranosyl derivative of 1,2,4-triazole-3-carboxamide. A synthetic guanosine analogue, it is an inhibitor of HCV polymerase and possesses a broad spectrum of activity against DNA and RNA viruses. | ribavirin |
| rx-3117 | A triol that is (1S,2R)-4-fluoro-3-(hydroxymethyl)cyclopent-3-ene-1,2-diol which is substituted by a 4-amino-2-oxopyrimidin-1(2H)-yl group at position 5. It is a cytidine analog which exhibits anticancer activity in several cancers, including gemcitabine-resistant tumours. | roducitabine |
| stavudine | A nucleoside analogue obtained by formal dehydration across positions 2 and 3 of thymidine. An inhibitor of HIV-1 reverse transcriptase | stavudine |
| thioguanine anhydrous | A 2-aminopurine that is the 6-thiono derivative of 2-amino-1,9-dihydro-6H-purine. Incorporates into DNA and inhibits synthesis. Used in the treatment of leukaemia. | tioguanine |
| thiouridine | A thiouridine in which the oxygen replaced by sulfur is that at C-4. | 4-thiouridine |
| toyocamycin | An N-glycosylpyrrolopyrimidine that is tubercidin in which the hydrogen at position 5 of the pyrrolopyrimidine moiety has been replaced by a cyano group. | toyocamycin |
| trifluridine | A pyrimidine 2'-deoxyribonucleoside compound having 5-trifluoromethyluracil as the nucleobase. An antiviral drug used mainly in the treatment of primary keratoconjunctivitis and recurrent epithelial keratitis. | trifluridine |
| tubercidin | An N-glycosylpyrrolopyrimidine that is adenosine in which the in the 5-membered ring that is not attached to the ribose moiety is replaced by a carbon. Tubercidin is produced in the culture broth of Streptomyces tubericidus. | tubercidin |
| zalcitabine | A pyrimidine 2',3'-dideoxyribonucleoside compound having cytosine as the nucleobase. | zalcitabine |
| zidovudine | A pyrimidine 2',3'-dideoxyribonucleoside compound having a 3'-azido substituent and thymine as the nucleobase. | zidovudine |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 31.0663 | 1 | 4 |
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 5.0016 | 1 | 2 |
| 67.9K protein | Vaccinia virus | Potency | 6.7437 | 2 | 25 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 35.0520 | 2 | 8 |
| acid sphingomyelinase | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 0.0886 | 2 | 8 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 32.0662 | 1 | 13 |
| alpha-galactosidase | Homo sapiens (human) | Potency | 29.7877 | 1 | 3 |
| Alpha-synuclein | Homo sapiens (human) | Potency | 5.6234 | 1 | 1 |
| Amyloid-beta precursor protein | Homo sapiens (human) | Potency | 18.3564 | 1 | 1 |
| apical membrane antigen 1, AMA1 | Plasmodium falciparum 3D7 | Potency | 29.7164 | 1 | 4 |
| AR protein | Homo sapiens (human) | Potency | 18.5638 | 12 | 86 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 31.6899 | 2 | 15 |
| arylsulfatase A | Homo sapiens (human) | Potency | 19.5879 | 1 | 5 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 9.3662 | 3 | 8 |
| Ataxin-2 | Homo sapiens (human) | Potency | 10.9872 | 2 | 13 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 17.9533 | 4 | 9 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 7.8254 | 2 | 14 |
| atrial natriuretic peptide receptor 1 precursor | Homo sapiens (human) | Potency | 8.4921 | 1 | 1 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 40.2011 | 2 | 16 |
| BRCA1 | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 28.2141 | 1 | 2 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 70.5473 | 1 | 1 |
| caspase-1 isoform alpha precursor | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| caspase-3 | Cricetulus griseus (Chinese hamster) | Potency | 15.7936 | 1 | 1 |
| caspase-3 | Homo sapiens (human) | Potency | 70.5473 | 1 | 1 |
| Caspase-7 | Cricetulus griseus (Chinese hamster) | Potency | 15.7936 | 1 | 1 |
| Caspase-7 | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 10.2984 | 3 | 60 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 7.6613 | 2 | 11 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 26.5864 | 1 | 3 |
| Chain A, ATP-DEPENDENT DNA HELICASE Q1 | Homo sapiens (human) | Potency | 0.7943 | 1 | 1 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 22.7406 | 1 | 2 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 20.7895 | 2 | 5 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 29.0941 | 2 | 3 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 14.5186 | 1 | 3 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 10.2240 | 2 | 12 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 13.7005 | 2 | 6 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 48.4516 | 2 | 6 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 29.0941 | 2 | 3 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 65.6444 | 2 | 16 |
| ClpP | Bacillus subtilis | Potency | 23.7358 | 1 | 2 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 21.4865 | 1 | 2 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 39.8107 | 1 | 3 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 16.7299 | 1 | 7 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 20.1955 | 1 | 5 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 16.4600 | 2 | 16 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 10.6015 | 2 | 13 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 9.8287 | 1 | 16 |
| D(1A) dopamine receptor | Sus scrofa (pig) | Potency | 0.9268 | 1 | 1 |
| Disintegrin and metalloproteinase domain-containing protein 17 | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| DNA dC->dU-editing enzyme APOBEC-3F isoform a | Homo sapiens (human) | Potency | 5.7997 | 2 | 4 |
| DNA dC->dU-editing enzyme APOBEC-3G isoform 1 | Homo sapiens (human) | Potency | 6.4471 | 3 | 5 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 59.6218 | 1 | 2 |
| DNA polymerase eta isoform 1 | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 86.1632 | 1 | 8 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 46.7791 | 1 | 2 |
| dopamine D1 receptor | Homo sapiens (human) | Potency | 4.6109 | 1 | 1 |
| endonuclease IV | Escherichia coli | Potency | 5.6186 | 2 | 3 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 18.8846 | 10 | 122 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 21.8332 | 2 | 10 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 13.1007 | 10 | 141 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 11.8066 | 1 | 23 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 8.4676 | 4 | 42 |
| eyes absent homolog 2 isoform a | Homo sapiens (human) | Potency | 100.0000 | 1 | 1 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 16.9101 | 4 | 22 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 16.9922 | 1 | 3 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 14.7540 | 1 | 9 |
| G | Vesicular stomatitis virus | Potency | 16.7299 | 1 | 7 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 16.4600 | 1 | 8 |
| GALC protein | Homo sapiens (human) | Potency | 0.7079 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 16.4600 | 1 | 8 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 16.4600 | 1 | 8 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 16.4600 | 1 | 8 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 16.4600 | 1 | 8 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 16.4600 | 1 | 8 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 16.4600 | 1 | 8 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 16.4600 | 1 | 8 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 16.4600 | 1 | 8 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 16.4600 | 1 | 8 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 16.4600 | 1 | 8 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 16.4600 | 1 | 8 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 16.4600 | 1 | 8 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 16.4600 | 1 | 8 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 16.4600 | 1 | 8 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 16.4600 | 1 | 8 |
| geminin | Homo sapiens (human) | Potency | 5.6817 | 3 | 39 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 13.4714 | 2 | 24 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 7.1692 | 1 | 7 |
| GLS protein | Homo sapiens (human) | Potency | 18.3186 | 2 | 5 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 20.0827 | 1 | 2 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 11.6603 | 3 | 20 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 29.6764 | 1 | 16 |
| Glycoprotein hormones alpha chain | Homo sapiens (human) | Potency | 2.8184 | 1 | 1 |
| GTP-binding nuclear protein Ran isoform 1 | Homo sapiens (human) | Potency | 0.8199 | 1 | 1 |
| Guanine nucleotide-binding protein G | Homo sapiens (human) | Potency | 15.4464 | 2 | 3 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 40.8710 | 1 | 2 |
| hemoglobin subunit beta | Homo sapiens (human) | Potency | 7.7872 | 5 | 19 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 39.8107 | 1 | 9 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 20.5151 | 1 | 7 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 40.6081 | 2 | 32 |
| histone-lysine N-methyltransferase 2A isoform 2 precursor | Homo sapiens (human) | Potency | 14.1254 | 1 | 1 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 16.7299 | 1 | 7 |
| huntingtin isoform 2 | Homo sapiens (human) | Potency | 1.9953 | 1 | 1 |
| hypothetical protein, conserved | Trypanosoma brucei | Potency | 14.1254 | 1 | 1 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 32.4638 | 1 | 2 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 4.7641 | 2 | 4 |
| IDH1 | Homo sapiens (human) | Potency | 3.4122 | 1 | 13 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 56.5110 | 2 | 2 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 16.7299 | 1 | 14 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 19.7020 | 1 | 2 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 7.3341 | 1 | 5 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 7.3341 | 1 | 5 |
| Interferon beta | Homo sapiens (human) | Potency | 17.2780 | 2 | 10 |
| interleukin 8 | Homo sapiens (human) | Potency | 68.3553 | 1 | 7 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 3.9398 | 2 | 28 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 56.3623 | 2 | 3 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 41.1766 | 1 | 4 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 22.7570 | 2 | 14 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 16.6945 | 2 | 3 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 11.0355 | 2 | 5 |
| muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 61.8527 | 1 | 3 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 5.0119 | 1 | 1 |
| NFKB1 protein, partial | Homo sapiens (human) | Potency | 1.9783 | 2 | 4 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 2.2247 | 1 | 3 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 19.4886 | 3 | 42 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 6.5597 | 2 | 16 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 0.0871 | 1 | 1 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 15.9803 | 1 | 4 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 7.1963 | 2 | 4 |
| nuclear receptor subfamily 1, group I, member 2 | Rattus norvegicus (Norway rat) | Potency | 19.9740 | 1 | 2 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 7.1933 | 3 | 60 |
| P53 | Homo sapiens (human) | Potency | 56.2341 | 1 | 1 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| Parkin | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |
| peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 35.5293 | 2 | 4 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 10.1442 | 2 | 13 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 33.3561 | 1 | 5 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 15.9072 | 4 | 18 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 30.6985 | 4 | 7 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 58.1891 | 1 | 8 |
| PINK1 | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 3.4720 | 1 | 11 |
| polyprotein | Zika virus | Potency | 14.7540 | 1 | 9 |
| polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | Potency | 25.5154 | 1 | 2 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| PPM1D protein | Homo sapiens (human) | Potency | 18.5569 | 1 | 2 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 30.6993 | 3 | 17 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 48.0224 | 1 | 2 |
| progesterone receptor | Homo sapiens (human) | Potency | 17.7950 | 2 | 9 |
| pyruvate kinase PKM isoform a | Homo sapiens (human) | Potency | 39.8107 | 2 | 2 |
| Rap guanine nucleotide exchange factor 3 | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 15.4853 | 2 | 33 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 1.0000 | 1 | 1 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 25.3255 | 1 | 2 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 22.3393 | 3 | 41 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 19.4781 | 3 | 28 |
| serine/threonine-protein kinase mTOR isoform 1 | Homo sapiens (human) | Potency | 8.8453 | 4 | 8 |
| serine/threonine-protein kinase PLK1 | Homo sapiens (human) | Potency | 29.9349 | 1 | 1 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 49.9420 | 2 | 2 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 49.9420 | 2 | 2 |
| Smad3 | Homo sapiens (human) | Potency | 6.1475 | 4 | 9 |
| snurportin-1 | Homo sapiens (human) | Potency | 56.5110 | 2 | 2 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 6.6578 | 2 | 15 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 10.6204 | 1 | 22 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 20.5436 | 1 | 4 |
| TDP1 protein | Homo sapiens (human) | Potency | 7.9887 | 2 | 110 |
| thioredoxin glutathione reductase | Schistosoma mansoni | Potency | 20.4434 | 1 | 3 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 21.6172 | 4 | 22 |
| Thrombopoietin | Homo sapiens (human) | Potency | 6.3010 | 2 | 4 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 9.2085 | 3 | 46 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 395.3634 | 4 | 6 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 15.6167 | 4 | 18 |
| transcriptional regulator ERG isoform 3 | Homo sapiens (human) | Potency | 22.9090 | 1 | 4 |
| tyrosine-protein kinase Yes | Homo sapiens (human) | Potency | 41.0704 | 1 | 2 |
| ubiquitin carboxyl-terminal hydrolase 2 isoform a | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 3.4720 | 1 | 11 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 3.4720 | 1 | 11 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 28.2580 | 2 | 2 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 27.2017 | 1 | 3 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 18.0704 | 3 | 7 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 52.8769 | 1 | 4 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 29.6764 | 1 | 16 |
| Vpr | Human immunodeficiency virus 1 | Potency | 10.0000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Homo sapiens (human) | IC50 | 4.0000 | 1 | 1 |
| 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Homo sapiens (human) | Ki | 0.0235 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | IC50 | 0.1106 | 2 | 2 |
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | IC50 | 0.0146 | 2 | 2 |
| 6-phosphogluconate dehydrogenase, decarboxylating | Homo sapiens (human) | Ki | 136.7000 | 1 | 1 |
| Adenosine deaminase | Homo sapiens (human) | Ki | 0.0001 | 8 | 8 |
| Adenosine deaminase | Bos taurus (cattle) | Ki | 0.0000 | 2 | 3 |
| Adenosine deaminase | Plasmodium falciparum (malaria parasite P. falciparum) | Ki | 0.0041 | 2 | 2 |
| Adenosine kinase | Homo sapiens (human) | IC50 | 1,292,888.1240 | 4 | 5 |
| Adenosine receptor A1 | Rattus norvegicus (Norway rat) | IC50 | 3,235,940.0000 | 1 | 1 |
| Adenosine receptor A1 | Homo sapiens (human) | Ki | 7.4100 | 2 | 2 |
| Adenosine receptor A1 | Mus musculus (house mouse) | Ki | 4.4300 | 1 | 1 |
| Adenosine receptor A1 | Rattus norvegicus (Norway rat) | Ki | 9.8133 | 3 | 3 |
| Adenosine receptor A2a | Rattus norvegicus (Norway rat) | IC50 | 3,235,940.0000 | 1 | 1 |
| Adenosine receptor A2a | Homo sapiens (human) | Ki | 7.4100 | 1 | 1 |
| Adenosine receptor A2b | Rattus norvegicus (Norway rat) | IC50 | 3,235,940.0000 | 1 | 1 |
| Adenosine receptor A3 | Homo sapiens (human) | IC50 | 21.6870 | 1 | 1 |
| Adenosine receptor A3 | Rattus norvegicus (Norway rat) | IC50 | 3,235,940.0000 | 1 | 1 |
| Adenosine receptor A3 | Homo sapiens (human) | Ki | 9.8340 | 2 | 2 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 21.6870 | 1 | 1 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 12.2580 | 1 | 1 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 21.6870 | 1 | 1 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 12.2580 | 1 | 1 |
| Apoptosis regulator Bcl-2 | Homo sapiens (human) | GI50 | 147.0000 | 1 | 1 |
| Aromatase | Homo sapiens (human) | IC50 | 2.8150 | 2 | 2 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 17 |
| ATP-binding cassette sub-family C member 3 | Rattus norvegicus (Norway rat) | Ki | 90.0000 | 1 | 1 |
| Bcl-2-like protein 1 | Homo sapiens (human) | GI50 | 183.0000 | 1 | 1 |
| Bifunctional dihydrofolate reductase-thymidylate synthase | Plasmodium falciparum K1 | IC50 | 0.0840 | 1 | 1 |
| Bifunctional dihydrofolate reductase-thymidylate synthase | Toxoplasma gondii | IC50 | 4.8493 | 32 | 54 |
| Bifunctional dihydrofolate reductase-thymidylate synthase | Trypanosoma cruzi | IC50 | 0.1100 | 1 | 1 |
| Bifunctional dihydrofolate reductase-thymidylate synthase | Leishmania major | Ki | 0.0001 | 1 | 1 |
| Bifunctional purine biosynthesis protein ATIC | Homo sapiens (human) | IC50 | 6.6933 | 2 | 3 |
| Bifunctional purine biosynthesis protein ATIC | Homo sapiens (human) | Ki | 100.4400 | 1 | 2 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 380.5429 | 5 | 35 |
| Bile salt export pump | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 4 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 17 |
| Canalicular multispecific organic anion transporter 1 | Rattus norvegicus (Norway rat) | Ki | 341.3333 | 3 | 3 |
| Carbonic anhydrase 1 | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| Carbonic anhydrase 2 | Homo sapiens (human) | Ki | 19.0000 | 2 | 2 |
| Carbonic anhydrase 4 | Homo sapiens (human) | Ki | 113.0000 | 1 | 1 |
| Carbonic anhydrase 5A, mitochondrial | Homo sapiens (human) | Ki | 15.5654 | 2 | 2 |
| Carbonic anhydrase 9 | Homo sapiens (human) | Ki | 23.0000 | 1 | 1 |
| Carnitine O-palmitoyltransferase 1, muscle isoform | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| cGMP-dependent 3',5'-cyclic phosphodiesterase | Homo sapiens (human) | IC50 | 3.1200 | 1 | 1 |
| Chain A, DEOXYNUCLEOSIDE KINASE | Drosophila melanogaster (fruit fly) | IC50 | 0.7600 | 1 | 1 |
| Chain A, N-methyl-D-aspartate Receptor Subunit 1 | Rattus norvegicus (Norway rat) | Ki | 241.0000 | 1 | 3 |
| Chain A, Purine nucleoside phosphorylase | Escherichia coli | Ki | 120.0000 | 1 | 1 |
| Chain A, Purine nucleoside phosphorylase DeoD-type | Escherichia coli O157:H7 | Ki | 120.0000 | 1 | 1 |
| Chain A, Thymidylate Synthase | Escherichia coli | Ki | 0.1090 | 1 | 2 |
| Chain A, Thymidylate Synthase | Homo sapiens (human) | Ki | 0.1090 | 1 | 1 |
| Chain A, Uracil Phosphoribosyltransferase | Toxoplasma gondii | Ki | 25.0000 | 1 | 1 |
| Chain E, Purine nucleoside phosphorylase | Homo sapiens (human) | Ki | 90.0000 | 1 | 1 |
| Cytidine deaminase | Homo sapiens (human) | Ki | 190.0000 | 1 | 1 |
| Cytochrome P450 11B1, mitochondrial | Homo sapiens (human) | IC50 | 0.0181 | 10 | 10 |
| Cytochrome P450 11B1, mitochondrial | Rattus norvegicus (Norway rat) | IC50 | 4.7357 | 3 | 3 |
| Cytochrome P450 11B1, mitochondrial | Bos taurus (cattle) | IC50 | 1.3060 | 3 | 6 |
| Cytochrome P450 11B2, mitochondrial | Homo sapiens (human) | IC50 | 0.0838 | 9 | 9 |
| Cytochrome P450 1A2 | Homo sapiens (human) | IC50 | 4.8000 | 2 | 2 |
| Cytochrome P450 2C19 | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| Cytochrome P450 2C8 | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Cytochrome P450 2D6 | Homo sapiens (human) | IC50 | 4.6000 | 1 | 1 |
| Cytochrome P450 2J2 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 2.8659 | 2 | 2 |
| Cytochrome P450 3A4 | Homo sapiens (human) | Ki | 190.0000 | 1 | 1 |
| D-alanine--D-alanine ligase | Enterococcus faecalis V583 | IC50 | 262.0000 | 1 | 1 |
| Delta-type opioid receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0030 | 1 | 1 |
| Deoxycytidine kinase | Homo sapiens (human) | Ki | 680.0000 | 2 | 2 |
| Deoxynucleoside kinase | Drosophila melanogaster (fruit fly) | IC50 | 5,319.0000 | 2 | 2 |
| Dihydrofolate reductase | Enterococcus faecium | IC50 | 0.0014 | 1 | 1 |
| Dihydrofolate reductase | Escherichia coli K-12 | IC50 | 103.1313 | 24 | 46 |
| Dihydrofolate reductase | Gallus gallus (chicken) | IC50 | 0.0545 | 2 | 2 |
| Dihydrofolate reductase | Homo sapiens (human) | IC50 | 2.4307 | 82 | 112 |
| Dihydrofolate reductase | Lacticaseibacillus casei | IC50 | 20.3740 | 29 | 34 |
| Dihydrofolate reductase | Mus musculus (house mouse) | IC50 | 0.0331 | 11 | 11 |
| Dihydrofolate reductase | Mycobacterium tuberculosis H37Rv | IC50 | 0.0174 | 3 | 3 |
| Dihydrofolate reductase | Pneumocystis carinii | IC50 | 16.4952 | 12 | 14 |
| Dihydrofolate reductase | Rattus norvegicus (Norway rat) | IC50 | 0.0047 | 10 | 11 |
| Dihydrofolate reductase | Escherichia coli K-12 | Ki | 34.5460 | 5 | 5 |
| Dihydrofolate reductase | Homo sapiens (human) | Ki | 0.2961 | 15 | 15 |
| Dihydrofolate reductase | Lacticaseibacillus casei | Ki | 0.0000 | 1 | 1 |
| Dihydrofolate reductase | Mus musculus (house mouse) | Ki | 0.2347 | 18 | 19 |
| Dihydrofolate reductase | Pneumocystis carinii | Ki | 0.0000 | 1 | 1 |
| Dihydrofolate reductase | Staphylococcus aureus | Ki | 0.0005 | 2 | 2 |
| Dihydrofolate reductase | Bacillus anthracis | IC50 | 0.0136 | 1 | 2 |
| Dihydrofolate reductase | Bos taurus (cattle) | IC50 | 722.1480 | 11 | 11 |
| Dihydroorotate dehydrogenase | Schistosoma mansoni | IC50 | 20.0000 | 2 | 2 |
| Dihydroorotate dehydrogenase (quinone), mitochondrial | Homo sapiens (human) | IC50 | 0.0115 | 26 | 26 |
| Dihydroorotate dehydrogenase (quinone), mitochondrial | Rattus norvegicus (Norway rat) | IC50 | 0.2042 | 4 | 5 |
| Dihydroorotate dehydrogenase (quinone), mitochondrial | Homo sapiens (human) | Ki | 0.0120 | 2 | 2 |
| Dihydropyrimidine dehydrogenase [NADP(+)] | Homo sapiens (human) | IC50 | 0.2200 | 1 | 1 |
| DNA polymerase beta | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| E3 ubiquitin-protein ligase Mdm2 | Homo sapiens (human) | IC50 | 0.0200 | 1 | 1 |
| Enoyl-[acyl-carrier-protein] reductase [NADH] | Francisella tularensis subsp. tularensis SCHU S4 | IC50 | 59.0000 | 1 | 1 |
| Epidermal growth factor receptor | Homo sapiens (human) | IC50 | 0.3200 | 1 | 1 |
| Equilibrative nucleoside transporter 1 | Homo sapiens (human) | IC50 | 0.1900 | 1 | 1 |
| exodeoxyribonuclease V subunit RecB | Escherichia coli str. K-12 substr. MG1655 | IC50 | 77.4898 | 2 | 4 |
| exodeoxyribonuclease V subunit RecC | Escherichia coli str. K-12 substr. MG1655 | IC50 | 77.4897 | 2 | 4 |
| exodeoxyribonuclease V subunit RecD | Escherichia coli str. K-12 substr. MG1655 | IC50 | 77.4898 | 2 | 4 |
| Fatty acid synthase | Gallus gallus (chicken) | IC50 | 13.0000 | 1 | 1 |
| Fatty acid synthase | Homo sapiens (human) | IC50 | 13.5533 | 3 | 3 |
| Fatty-acid amide hydrolase 1 | Mus musculus (house mouse) | IC50 | 0.0800 | 1 | 1 |
| Folate receptor alpha | Homo sapiens (human) | IC50 | 0.2936 | 6 | 12 |
| Folate receptor beta | Homo sapiens (human) | IC50 | 0.2185 | 6 | 10 |
| Folylpolyglutamate synthase, mitochondrial | Homo sapiens (human) | IC50 | 3.2000 | 1 | 1 |
| Folylpolyglutamate synthase, mitochondrial | Mus musculus (house mouse) | Ki | 166.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Homo sapiens (human) | Ki | 113.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Homo sapiens (human) | Ki | 113.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Homo sapiens (human) | Ki | 113.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Homo sapiens (human) | Ki | 113.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Homo sapiens (human) | Ki | 113.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Homo sapiens (human) | Ki | 113.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Homo sapiens (human) | Ki | 113.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Homo sapiens (human) | Ki | 113.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Homo sapiens (human) | Ki | 113.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit delta | Homo sapiens (human) | Ki | 113.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit epsilon | Homo sapiens (human) | Ki | 113.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Homo sapiens (human) | Ki | 113.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Homo sapiens (human) | Ki | 113.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Homo sapiens (human) | Ki | 113.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit pi | Homo sapiens (human) | Ki | 113.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit theta | Homo sapiens (human) | Ki | 113.0000 | 1 | 2 |
| Genome polyprotein | Human rhinovirus sp. | IC50 | 2,500.0000 | 1 | 1 |
| Glucose-6-phosphate 1-dehydrogenase | Homo sapiens (human) | Ki | 91.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 1 | Rattus norvegicus (Norway rat) | IC50 | 4.8350 | 2 | 2 |
| Glutamate receptor ionotropic, NMDA 2A | Rattus norvegicus (Norway rat) | IC50 | 2.3000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2B | Rattus norvegicus (Norway rat) | IC50 | 2.3000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2C | Rattus norvegicus (Norway rat) | IC50 | 2.3000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2D | Rattus norvegicus (Norway rat) | IC50 | 2.3000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3A | Rattus norvegicus (Norway rat) | IC50 | 2.3000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3B | Rattus norvegicus (Norway rat) | IC50 | 2.3000 | 1 | 1 |
| Histamine H3 receptor | Cavia porcellus (domestic guinea pig) | IC50 | 8.6900 | 1 | 1 |
| Histidine decarboxylase | Rattus norvegicus (Norway rat) | IC50 | 0.0014 | 1 | 1 |
| Histone-lysine N-methyltransferase, H3 lysine-79 specific | Homo sapiens (human) | IC50 | 44.0000 | 1 | 1 |
| Janus kinase 2 (a protein tyrosine kinase) | Homo sapiens (human) | IC50 | 6.7980 | 1 | 1 |
| Kappa-type opioid receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0030 | 1 | 1 |
| Mitogen-activated protein kinase 3 | Homo sapiens (human) | IC50 | 5.5160 | 1 | 1 |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0030 | 1 | 1 |
| Multidrug resistance associated protein | Homo sapiens (human) | Ki | 1,200.0000 | 1 | 1 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 17 |
| Myeloperoxidase | Homo sapiens (human) | IC50 | 2.8100 | 1 | 1 |
| NADH-cytochrome b5 reductase 3 | Homo sapiens (human) | IC50 | 279.4000 | 1 | 1 |
| Nicotinamide N-methyltransferase | Homo sapiens (human) | IC50 | 3.6200 | 1 | 1 |
| NPC1-like intracellular cholesterol transporter 1 | Homo sapiens (human) | IC50 | 0.3700 | 1 | 1 |
| NPC1-like intracellular cholesterol transporter 1 | Rattus norvegicus (Norway rat) | Ki | 0.2000 | 1 | 1 |
| nuclear receptor coactivator 1 isoform 1 [Homo sapiens] | Homo sapiens (human) | IC50 | 32.4483 | 2 | 3 |
| nuclear receptor coactivator 3 isoform a | Homo sapiens (human) | IC50 | 14.5410 | 2 | 3 |
| Nuclear receptor ROR-gamma | Mus musculus (house mouse) | IC50 | 11.1000 | 1 | 1 |
| Orotidine 5'-phosphate decarboxylase | Methanothermobacter thermautotrophicus str. Delta H | Ki | 8.6000 | 1 | 2 |
| Orotidine 5'-phosphate decarboxylase | Saccharomyces cerevisiae S288C | Ki | 0.0640 | 1 | 1 |
| Phosphatidylinositol 4-kinase alpha | Homo sapiens (human) | IC50 | 341.6000 | 1 | 1 |
| Phosphatidylinositol 4-kinase alpha | Homo sapiens (human) | Ki | 235.4000 | 1 | 1 |
| Phosphatidylinositol 4-kinase beta | Homo sapiens (human) | IC50 | 341.6000 | 1 | 1 |
| Phosphatidylinositol 4-kinase beta | Homo sapiens (human) | Ki | 235.4000 | 1 | 1 |
| Phosphatidylinositol 4-kinase type 2-alpha | Homo sapiens (human) | IC50 | 341.6000 | 1 | 1 |
| Phosphatidylinositol 4-kinase type 2-alpha | Homo sapiens (human) | Ki | 235.4000 | 1 | 1 |
| Phosphatidylinositol 4-kinase type 2-beta | Homo sapiens (human) | IC50 | 341.6000 | 1 | 1 |
| Phosphatidylinositol 4-kinase type 2-beta | Homo sapiens (human) | Ki | 235.4000 | 1 | 1 |
| Polyphenol oxidase 2 | Agaricus bisporus | IC50 | 1,000.0000 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15 | Oryctolagus cuniculus (rabbit) | IC50 | 16.1590 | 1 | 1 |
| Programmed cell death protein 4 | Homo sapiens (human) | IC50 | 0.8800 | 1 | 1 |
| Prostaglandin G/H synthase 1 | Homo sapiens (human) | IC50 | 8.4215 | 1 | 2 |
| Protease | Human immunodeficiency virus 1 | IC50 | 10.5090 | 4 | 5 |
| Protein kinase C beta type | Homo sapiens (human) | IC50 | 150.0000 | 1 | 1 |
| Protein kinase C epsilon type | Homo sapiens (human) | IC50 | 150.0000 | 1 | 1 |
| Protein-arginine deiminase type-4 | Homo sapiens (human) | IC50 | 9,050.0000 | 1 | 2 |
| Proton-coupled amino acid transporter 1 | Homo sapiens (human) | Ki | 4,400.0000 | 1 | 1 |
| Proton-coupled folate transporter | Homo sapiens (human) | IC50 | 0.0516 | 5 | 8 |
| Proton-coupled folate transporter | Homo sapiens (human) | Ki | 0.6776 | 7 | 7 |
| Pteridine reductase 1 | Leishmania major | Ki | 0.1095 | 2 | 2 |
| Purine nucleoside phosphorylase | Homo sapiens (human) | Ki | 135.5000 | 2 | 2 |
| Reduced folate transporter | Homo sapiens (human) | IC50 | 0.0611 | 5 | 8 |
| Reduced folate transporter | Homo sapiens (human) | Ki | 3.5000 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | IC50 | 18.4000 | 4 | 4 |
| Reverse transcriptase/RNaseH | Human immunodeficiency virus 1 | IC50 | 15.8631 | 25 | 26 |
| Reverse transcriptase/RNaseH | Human immunodeficiency virus 1 | Ki | 0.0510 | 1 | 1 |
| Ribonucleoside-diphosphate reductase large subunit | Homo sapiens (human) | IC50 | 997.0000 | 1 | 1 |
| RNA-directed RNA polymerase | | IC50 | 15.4000 | 2 | 2 |
| Serine hydroxymethyltransferase, cytosolic | Homo sapiens (human) | Ki | 79.2333 | 3 | 3 |
| Shiga toxin subunit A | Shigella dysenteriae | IC50 | 23.9000 | 1 | 1 |
| Sodium/bile acid cotransporter | Homo sapiens (human) | Ki | 25.0000 | 1 | 1 |
| Sodium/nucleoside cotransporter 2 | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| Solute carrier family 15 member 1 | Homo sapiens (human) | IC50 | 12,210.0000 | 1 | 1 |
| Solute carrier family 22 member 20 | Mus musculus (house mouse) | Ki | 599.7800 | 1 | 2 |
| Solute carrier family 22 member 6 | Mus musculus (house mouse) | Ki | 896.1255 | 1 | 2 |
| Steroid 17-alpha-hydroxylase/17,20 lyase | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Sterol 14-alpha demethylase | Trypanosoma cruzi strain CL Brener | IC50 | 100.0000 | 1 | 1 |
| Thymidine kinase | Human alphaherpesvirus 1 (Herpes simplex virus type 1) | IC50 | 561.0000 | 2 | 2 |
| Thymidine kinase | Human alphaherpesvirus 1 strain SC16 | IC50 | 1,000.0000 | 1 | 1 |
| Thymidine kinase | Human herpesvirus 3 strain Dumas | IC50 | 1,000.0000 | 2 | 2 |
| Thymidine kinase | Ureaplasma parvum serovar 3 str. ATCC 700970 | IC50 | 12.5000 | 1 | 1 |
| Thymidine kinase | Human alphaherpesvirus 2 | IC50 | 200.0000 | 1 | 1 |
| Thymidine kinase | Macacine alphaherpesvirus 1 | IC50 | 501.0000 | 1 | 2 |
| Thymidine kinase | Staphylococcus aureus | Ki | 944.0000 | 1 | 1 |
| Thymidine kinase 2 | Rattus norvegicus (Norway rat) | Ki | 3,250.0000 | 1 | 1 |
| Thymidine kinase 2, mitochondrial | Homo sapiens (human) | IC50 | 1,000.0000 | 2 | 2 |
| Thymidine kinase, cytosolic | Homo sapiens (human) | IC50 | 667.6667 | 3 | 3 |
| Thymidine kinase, cytosolic | Homo sapiens (human) | Ki | 205.8267 | 4 | 6 |
| Thymidine kinase, cytosolic | Rattus norvegicus (Norway rat) | Ki | 1,700.0000 | 1 | 1 |
| Thymidylate kinase | Homo sapiens (human) | Ki | 214.0000 | 1 | 1 |
| Thymidylate kinase | Mycobacterium tuberculosis H37Rv | Ki | 124.3333 | 4 | 6 |
| Thymidylate synthase | Escherichia coli K-12 | IC50 | 11.4303 | 3 | 12 |
| Thymidylate synthase | Homo sapiens (human) | IC50 | 24.5031 | 28 | 43 |
| Thymidylate synthase | Lacticaseibacillus casei | IC50 | 121.2143 | 14 | 14 |
| Thymidylate synthase | Mus musculus (house mouse) | IC50 | 6.4061 | 16 | 22 |
| Thymidylate synthase | Homo sapiens (human) | Ki | 0.2356 | 4 | 4 |
| Thymidylate synthase | Lacticaseibacillus casei | Ki | 0.5500 | 1 | 1 |
| Thymidylate synthase | Mus musculus (house mouse) | Ki | 22.6700 | 2 | 2 |
| Thymidylate synthase | Escherichia coli | IC50 | 110.6812 | 13 | 16 |
| Thymidylate synthase | Escherichia coli LF82 | IC50 | 47.0000 | 1 | 2 |
| Thymidylate synthase | Rattus norvegicus (Norway rat) | IC50 | 20.0000 | 1 | 1 |
| Thyroid peroxidase | Homo sapiens (human) | IC50 | 3.3800 | 1 | 1 |
| Toll-like receptor 4 | Homo sapiens (human) | IC50 | 1.0400 | 1 | 1 |
| TPA: protein transporter TIM23 | Saccharomyces cerevisiae S288C | IC50 | 14.0000 | 1 | 1 |
| transactivating tegument protein VP16 [Human herpesvirus 1] | Human alphaherpesvirus 1 (Herpes simplex virus type 1) | IC50 | 29.3350 | 2 | 3 |
| Transcriptional activator protein LasR | Pseudomonas aeruginosa PAO1 | IC50 | 0.6400 | 1 | 1 |
| Trifunctional purine biosynthetic protein adenosine-3 | Homo sapiens (human) | IC50 | 6.2726 | 7 | 8 |
| Trifunctional purine biosynthetic protein adenosine-3 | Mus musculus (house mouse) | IC50 | 20.0000 | 5 | 5 |
| Trifunctional purine biosynthetic protein adenosine-3 | Homo sapiens (human) | Ki | 0.6113 | 4 | 4 |
| UDP-glucose 6-dehydrogenase | Rattus norvegicus (Norway rat) | Ki | 288.0000 | 1 | 1 |
| UDP-glucose 6-dehydrogenase | Streptococcus pyogenes | Ki | 199.5000 | 2 | 2 |
| UDP-glucuronosyltransferase 1A1 | Rattus norvegicus (Norway rat) | Ki | 100.0000 | 1 | 1 |
| UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase | Staphylococcus epidermidis RP62A | IC50 | 300.0000 | 1 | 1 |
| Urease subunit alpha | Helicobacter pylori 26695 | IC50 | 100.0000 | 1 | 1 |
| Urease subunit beta | Helicobacter pylori 26695 | IC50 | 100.0000 | 1 | 1 |
| Uridine 5'-monophosphate synthase | Homo sapiens (human) | Ki | 0.0170 | 1 | 1 |
| Voltage-dependent calcium channel subunit alpha-2/delta-1 | Mus musculus (house mouse) | Ki | 0.1024 | 1 | 2 |
| Voltage-dependent L-type calcium channel subunit alpha-1C | Homo sapiens (human) | IC50 | 622.5000 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1D | Homo sapiens (human) | IC50 | 622.5000 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1F | Homo sapiens (human) | IC50 | 622.5000 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1S | Homo sapiens (human) | IC50 | 622.5000 | 1 | 1 |
| Xanthine dehydrogenase/oxidase | Bos taurus (cattle) | IC50 | 13.7520 | 42 | 42 |
| Xanthine dehydrogenase/oxidase | Homo sapiens (human) | IC50 | 17.4356 | 40 | 42 |
| Xanthine dehydrogenase/oxidase | Bos taurus (cattle) | Ki | 1.8000 | 2 | 2 |
| Xanthine dehydrogenase/oxidase | Homo sapiens (human) | Ki | 2.8917 | 6 | 6 |
| Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase | Rattus norvegicus (Norway rat) | IC50 | 9.3177 | 3 | 3 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | Escherichia coli K-12 | Kd | 18.0000 | 1 | 1 |
| Adenosine receptor A2a | Homo sapiens (human) | Kd | 77.0000 | 1 | 1 |
| Albumin | Homo sapiens (human) | Kd | 44.0000 | 1 | 4 |
| Angiotensin-converting enzyme 2 | Homo sapiens (human) | EC50 | 38.5533 | 1 | 3 |
| C-X-C chemokine receptor type 4 | Homo sapiens (human) | EC50 | 0.0880 | 1 | 1 |
| Carbonic anhydrase 2 | Homo sapiens (human) | EC50 | 0.0010 | 1 | 1 |
| Chain A, Calmodulin-sensitive adenylate cyclase | Bacillus anthracis | Kd | 130.0000 | 1 | 1 |
| Chain A, RIO-type serine/threonine-protein kinase Rio1 | Archaeoglobus fulgidus | Kd | 0.0400 | 1 | 1 |
| Chain B, DIHYDROFOLATE REDUCTASE | Escherichia coli | Kd | 0.1344 | 1 | 5 |
| Cyclin-dependent kinase 2 | Homo sapiens (human) | EC50 | 0.0010 | 1 | 1 |
| Dihydrofolate reductase | Escherichia coli K-12 | EC50 | 0.0010 | 1 | 1 |
| Dihydrofolate reductase | Escherichia coli K-12 | Kd | 0.3062 | 10 | 10 |
| Dihydroorotate dehydrogenase (quinone), mitochondrial | Homo sapiens (human) | EC50 | 0.0550 | 1 | 1 |
| Estrogen receptor | Rattus norvegicus (Norway rat) | EC50 | 150.0000 | 1 | 2 |
| Estrogen receptor beta | Rattus norvegicus (Norway rat) | EC50 | 150.0000 | 1 | 2 |
| Genome polyprotein | Human enterovirus 71 (strain BRCR) | EC50 | 100.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 1 | Rattus norvegicus (Norway rat) | EC50 | 2.9500 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2A | Rattus norvegicus (Norway rat) | EC50 | 2.9500 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2B | Rattus norvegicus (Norway rat) | EC50 | 2.9500 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2C | Rattus norvegicus (Norway rat) | EC50 | 10.5250 | 2 | 2 |
| Glutamate receptor ionotropic, NMDA 2D | Rattus norvegicus (Norway rat) | EC50 | 2.9500 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3A | Rattus norvegicus (Norway rat) | EC50 | 2.9500 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3B | Rattus norvegicus (Norway rat) | EC50 | 2.9500 | 1 | 1 |
| glycogen synthase kinase-3 beta isoform 1 | Homo sapiens (human) | EC50 | 300.0000 | 1 | 2 |
| Heat shock cognate 71 kDa protein | Homo sapiens (human) | Kd | 59.3462 | 1 | 4 |
| heat shock protein 90 | Candida albicans | EC50 | 150.0000 | 1 | 1 |
| High mobility group protein B1 | Homo sapiens (human) | Kd | 0.2620 | 2 | 2 |
| Histamine H1 receptor | Cavia porcellus (domestic guinea pig) | EC50 | 46.0000 | 1 | 1 |
| Hsf1 protein | Mus musculus (house mouse) | EC50 | 3.0570 | 1 | 1 |
| NS5 | Zika virus | EC50 | 5.2000 | 5 | 5 |
| Nuclear hormone receptor family member daf-12 | Caenorhabditis elegans | EC50 | 67.5260 | 1 | 1 |
| oxysterols receptor LXR-beta isoform 1 | Homo sapiens (human) | EC50 | 67.5260 | 1 | 1 |
| Polymerase acidic protein | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) | EC50 | 21.2667 | 3 | 3 |
| Polymerase basic protein 2 | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) | EC50 | 20.0000 | 2 | 2 |
| Procathepsin L | Homo sapiens (human) | EC50 | 38.5533 | 1 | 3 |
| Protease | Human immunodeficiency virus 1 | EC50 | 0.1260 | 1 | 1 |
| Purine nucleoside phosphorylase | Mycobacterium tuberculosis H37Rv | Kd | 364.0073 | 1 | 3 |
| Replicase polyprotein 1a | Severe acute respiratory syndrome-related coronavirus | EC50 | 38.5533 | 1 | 3 |
| Replicase polyprotein 1ab | Betacoronavirus England 1 | EC50 | 38.5533 | 1 | 3 |
| Replicase polyprotein 1ab | Human coronavirus 229E | EC50 | 38.5533 | 1 | 3 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | EC50 | 38.5533 | 1 | 3 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | EC50 | 38.5533 | 1 | 3 |
| Reverse transcriptase/RNaseH | Human immunodeficiency virus 1 | EC50 | 0.9665 | 25 | 27 |
| Reverse transcriptase/RNaseH | Human immunodeficiency virus 1 | Kd | 0.0054 | 1 | 1 |
| RNA-directed RNA polymerase | | EC50 | 46.0000 | 1 | 1 |
| RNA-directed RNA polymerase catalytic subunit | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) | EC50 | 21.2667 | 3 | 3 |
| Serine hydroxymethyltransferase, cytosolic | Homo sapiens (human) | Kd | 16.9000 | 1 | 1 |
| Spike glycoprotein | Betacoronavirus England 1 | EC50 | 38.5533 | 1 | 3 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | EC50 | 38.5533 | 1 | 3 |
| streptokinase A precursor | Streptococcus pyogenes M1 GAS | EC50 | 51.8590 | 2 | 3 |
| Stromelysin-1 | Homo sapiens (human) | Kd | 25,000.0000 | 1 | 1 |
| SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2, isoform CRA_a | Homo sapiens (human) | EC50 | 91.1700 | 1 | 1 |
| Taste receptor type 2 member 38 | Homo sapiens (human) | EC50 | 2.0000 | 1 | 1 |
| Transmembrane protease serine 2 | Homo sapiens (human) | EC50 | 38.5533 | 1 | 3 |
| Tyrosine-protein kinase ABL1 | Homo sapiens (human) | EC50 | 0.0010 | 1 | 1 |
| Xanthine dehydrogenase/oxidase | Bos taurus (cattle) | Kd | 0.0005 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | ID50 | 0.0500 | 1 | 1 |
| AAA family ATPase | Staphylococcus aureus | Km | 192.0000 | 1 | 1 |
| Adenosylhomocysteinase | Homo sapiens (human) | Kinact | 266.0000 | 1 | 1 |
| Adenosylhomocysteinase | Homo sapiens (human) | KR | 407.0000 | 1 | 1 |
| ATP-binding cassette sub-family C member 11 | Homo sapiens (human) | Km | 957.0000 | 1 | 1 |
| ATP-binding cassette sub-family C member 3 | Rattus norvegicus (Norway rat) | Km | 8.1000 | 2 | 2 |
| Broad substrate specificity ATP-binding cassette transporter ABCG2 | Homo sapiens (human) | Km | 2,560.0000 | 3 | 3 |
| Canalicular multispecific organic anion transporter 1 | Rattus norvegicus (Norway rat) | Km | 296.0000 | 1 | 1 |
| Carbonic anhydrase 2 | Homo sapiens (human) | Kinact | 28.0000 | 1 | 1 |
| Carbonic anhydrase 9 | Homo sapiens (human) | Kinact | 23.0000 | 1 | 1 |
| Cytidine deaminase | Homo sapiens (human) | Km | 359.3333 | 6 | 6 |
| Deoxycytidine kinase | Homo sapiens (human) | Km | 2.1967 | 3 | 3 |
| Dihydrofolate reductase | Homo sapiens (human) | IC80 | 1.4400 | 1 | 1 |
| Dihydrofolate reductase | Lacticaseibacillus casei | ID50 | 0.0130 | 5 | 5 |
| Dihydrofolate reductase | Mus musculus (house mouse) | ID50 | 0.0171 | 6 | 6 |
| Ectonucleoside triphosphate diphosphohydrolase 1 | Bos taurus (cattle) | Km | 2.9000 | 1 | 1 |
| Folylpolyglutamate synthase, mitochondrial | Mus musculus (house mouse) | Concentration | 47.0000 | 1 | 2 |
| Folylpolyglutamate synthase, mitochondrial | Homo sapiens (human) | Km | 71.3333 | 3 | 3 |
| Folylpolyglutamate synthase, mitochondrial | Mus musculus (house mouse) | Km | 165.0000 | 1 | 1 |
| Folylpolyglutamate synthase, mitochondrial | Homo sapiens (human) | Vmax | 0.8200 | 1 | 1 |
| Hsf1 protein | Mus musculus (house mouse) | AC50 | 6.8310 | 2 | 2 |
| HSP40, subfamily A [Plasmodium falciparum 3D7] | Plasmodium falciparum 3D7 | AbsAC1000_uM | 6.2810 | 1 | 2 |
| Hypoxanthine-guanine phosphoribosyltransferase | Homo sapiens (human) | Km | 38.0929 | 2 | 7 |
| interferon gamma precursor | Homo sapiens (human) | AC50 | 0.3460 | 1 | 1 |
| Liver carboxylesterase 1 | Homo sapiens (human) | Km | 1,300.0000 | 1 | 1 |
| LMP1 [Human herpesvirus 4] | human gammaherpesvirus 4 (Epstein-Barr virus) | AbsAC35_uM | 7.2400 | 1 | 1 |
| LMP1 [Human herpesvirus 4] | human gammaherpesvirus 4 (Epstein-Barr virus) | AC50 | 1.1180 | 2 | 4 |
| Microphthalmia-associated transcription factor | Homo sapiens (human) | AC50 | 0.8750 | 3 | 3 |
| MSH | Drosophila melanogaster (fruit fly) | AC50 | 3.9800 | 1 | 1 |
| Multidrug resistance associated protein | Homo sapiens (human) | Km | 768.6667 | 3 | 3 |
| Multidrug resistance-associated protein 1 | Homo sapiens (human) | Km | 1,540.0000 | 2 | 2 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | Km | 1,300.0000 | 1 | 1 |
| PAX8 | Homo sapiens (human) | AC50 | 0.5667 | 3 | 3 |
| POU domain, class 2, transcription factor 2 | Homo sapiens (human) | Km | 94.0000 | 1 | 1 |
| Probable deoxycytidylate deaminase | Caenorhabditis elegans | Km | 160.0000 | 1 | 1 |
| Proton-coupled folate transporter | Homo sapiens (human) | K | 0.1570 | 2 | 2 |
| Reverse transcriptase/RNaseH | Human immunodeficiency virus 1 | CC50 | 67.0000 | 1 | 2 |
| Reverse transcriptase/RNaseH | Human immunodeficiency virus 1 | CD50 | 70.0000 | 1 | 1 |
| Reverse transcriptase/RNaseH | Human immunodeficiency virus 1 | ED50 | 0.0267 | 3 | 3 |
| Reverse transcriptase/RNaseH | Human immunodeficiency virus 1 | IC90 | 0.1000 | 1 | 1 |
| Skn7p | Saccharomyces cerevisiae (brewer's yeast) | AbsAC40_uM | 5.1010 | 1 | 2 |
| Solute carrier family 22 member 1 | Homo sapiens (human) | Km | 151.2000 | 1 | 1 |
| Solute carrier family 22 member 11 | Homo sapiens (human) | Km | 84.8000 | 2 | 2 |
| Solute carrier family 22 member 6 | Homo sapiens (human) | Km | 445.2500 | 3 | 4 |
| Solute carrier family 22 member 6 | Rattus norvegicus (Norway rat) | Km | 155.0000 | 1 | 2 |
| Solute carrier family 22 member 7 | Homo sapiens (human) | Km | 26.8000 | 1 | 1 |
| Solute carrier family 22 member 7 | Rattus norvegicus (Norway rat) | Km | 1,513.0000 | 1 | 2 |
| Solute carrier family 22 member 8 | Homo sapiens (human) | Km | 237.2750 | 4 | 4 |
| Solute carrier family 22 member 8 | Mus musculus (house mouse) | Km | 2.0319 | 1 | 2 |
| Solute carrier organic anion transporter family member 1A3 | Rattus norvegicus (Norway rat) | Km | 29.1000 | 4 | 5 |
| Solute carrier organic anion transporter family member 1B3 | Homo sapiens (human) | Km | 24.7000 | 1 | 1 |
| Taste receptor type 2 member 38 | Homo sapiens (human) | Activity | 0.3000 | 1 | 1 |
| Thymidine kinase | Ureaplasma parvum serovar 3 str. ATCC 700970 | Km | 2.7000 | 1 | 1 |
| Thymidine kinase | Vaccinia virus WR | Km | 71.5000 | 1 | 2 |
| Thymidine kinase | Staphylococcus aureus | Km | 11.6000 | 1 | 1 |
| Thymidine kinase, cytosolic | Homo sapiens (human) | Km | 24.3500 | 6 | 6 |
| Thymidine kinase, cytosolic | Rattus norvegicus (Norway rat) | Phosphorylation rate | 4.0000 | 1 | 1 |
| Thymidine phosphorylase | Homo sapiens (human) | Km | 516.6667 | 1 | 3 |
| Thymidylate synthase | Mus musculus (house mouse) | ED50 | 0.0300 | 1 | 1 |
| Thymidylate synthase | Mus musculus (house mouse) | ID50 | 0.0350 | 1 | 1 |
| UDP-glucuronosyltransferase 1A1 | Homo sapiens (human) | Km | 64.0000 | 1 | 1 |
| UDP-glucuronosyltransferase 1A3 | Homo sapiens (human) | Km | 42.0000 | 1 | 1 |
| UDP-glucuronosyltransferase 2B7 | Homo sapiens (human) | Km | 395.5000 | 1 | 2 |
| Uridine phosphorylase 1 | Homo sapiens (human) | Km | 6,000.0000 | 1 | 1 |
| Xanthine dehydrogenase/oxidase | Bos taurus (cattle) | Km | 58.3750 | 4 | 4 |