Glanders

A contagious disease of horses that can be transmitted to humans. It is caused by BURKHOLDERIA MALLEI and characterized by ulceration of the respiratory mucosa and an eruption of nodules on the skin.

Synonym
Glanders

Excerpt	Reference
"Melioidosis and glanders are caused by the closely related species Burkholderia pseudomallei and Burkholderia mallei, respectively."	( Bell, DL; Eley, SM; Ellis, J; Green, M; Kenny, DJ; Russell, P; Titball, RW, 2000)
"Glanders is a zoonotic infection inducing acute forms of the disease (pneumonia, sepsis) in humans and animals under certain conditions, which even with the use of modern chemotherapy have unfavourable prognosis."	( Iliukhin, VI; Korol', EV; Kulikova, AS; Nekhezina, MO; Plekhanova, NG; Rotov, KA; Senina, TV; Shubnikova, EV; Snatenkov, EA; Tikhonov, SN, 2012)
"Equine glanders is an infectious and notifiable bacterial disease caused by Burkholderia mallei."	( Agarwal, SK; Arora, R; Baalasundaram, SK; Bhatt, L; Dubey, P; Gulati, BR; Gupta, S; Kanani, A; Kanwar, P; Khasa, V; Khurana, SK; Limaye, V; Malik, P; Mandal, BN; Mital, A; Parnam, S; Saini, S; Sangha, S; Shah, N; Shanmugasundaram, K; Sharma, H; Singha, H; Tapase, J; Tripathi, BN; Virmani, N, 2020)
"Glanders is a highly contagious and fatal infection of equids caused by the bacteria known as Burkholderia mallei."	( Saini, S; Shanmugasundaram, K; Singha, H; Tripathi, BN, 2021)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	13 (34.21)	23.3326
1990's	4 (10.53)	12.5806
2000's	4 (10.53)	18.1394
2010's	12 (31.58)	28.8240
2020's	5 (13.16)	9.53

Drug	Relationship Strength	Studies
glycerol	low	1
toluene	low	1
chloroquine	low	1
ciprofloxacin	low	4
gentamicin	low	1
nalidixic acid	low	1
norfloxacin	low	1
ofloxacin	low	2
sulfadiazine	low	2
sulfanilamide	low	2
chloramphenicol	low	1
kanamycin a	low	1
streptomycin	low	4
gold	low	2
imipenem, anhydrous	low	1
cyclopropanol	low	1
beta-lactams	low	1
levofloxacin	low	1
moxifloxacin	low	1
trimethoprim, sulfamethoxazole drug combination	low	5
meropenem	low	2
zithromax	low	1
amoxicillin-potassium clavulanate combination	low	1
glycolipids	low	1
heme	low	1
ascorbic acid	low	1
novobiocin	low	1
tetracycline	low	1
minocycline	low	1
methacycline	low	1
agar	low	1
lactoferrin	low	1

Protein Targets (477)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, Hyaluronidase, phage associated	0	1	0	1
acetylcholinesterase	2	0	0	2
RAR-related orphan receptor gamma	2	0	0	2
GLI family zinc finger 3	6	0	0	6
AR protein	7	0	0	7
thioredoxin glutathione reductase	1	0	0	1
cytochrome P450 family 3 subfamily A polypeptide 4	4	0	0	4
glucocorticoid receptor [Homo sapiens]	4	0	0	4
retinoic acid nuclear receptor alpha variant 1	6	0	0	6
estrogen-related nuclear receptor alpha	7	0	0	7
estrogen nuclear receptor alpha	10	0	0	10
vitamin D (1,25- dihydroxyvitamin D3) receptor	3	0	0	3
IDH1	2	0	0	2
euchromatic histone-lysine N-methyltransferase 2	10	0	0	10
chromobox protein homolog 1	5	0	0	5
nuclear factor erythroid 2-related factor 2 isoform 2	2	0	0	2
thyroid hormone receptor beta isoform 2	5	0	0	5
nuclear factor erythroid 2-related factor 2 isoform 1	6	0	0	6
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
geminin	6	0	0	6
lethal factor (plasmid)	5	0	0	5
lamin isoform A-delta10	8	0	0	8
Polyphenol oxidase 2	0	1	0	1
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	1	0	1
Urease	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	1	0	1
Alpha-2B adrenergic receptor	0	1	1	2
Spike glycoprotein	5	1	1	7
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
interleukin 8	4	0	0	4
TDP1 protein	11	0	0	11
aldehyde dehydrogenase 1 family, member A1	7	0	0	7
EWS/FLI fusion protein	9	0	0	9
farnesoid X nuclear receptor	1	0	0	1
pregnane X nuclear receptor	4	0	0	4
G	2	0	0	2
cytochrome P450 2D6	1	0	0	1
peroxisome proliferator activated receptor gamma	2	0	0	2
aryl hydrocarbon receptor	2	0	0	2
activating transcription factor 6	3	0	0	3
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	1	0	0	1
heat shock protein beta-1	1	0	0	1
DNA polymerase iota isoform a (long)	1	0	0	1
streptokinase A precursor	0	0	5	5
Dihydroxyacetone phosphate acyltransferase	0	0	0	2
ATP-binding cassette sub-family C member 3	0	14	0	14
Multidrug resistance-associated protein 4	0	14	0	14
Bile salt export pump	0	18	0	18
Interferon beta	4	0	0	4
HLA class I histocompatibility antigen, B alpha chain	2	0	0	2
30S ribosomal protein S6	0	3	0	3
30S ribosomal protein S7	0	3	0	3
50S ribosomal protein L15	0	3	0	3
Cellular tumor antigen p53	4	0	0	4
Cytochrome P450 3A4	0	5	0	5
50S ribosomal protein L10	0	3	0	3
50S ribosomal protein L11	0	3	0	3
50S ribosomal protein L7/L12	0	3	0	3
50S ribosomal protein L19	0	3	0	3
50S ribosomal protein L1	0	3	0	3
50S ribosomal protein L20	0	3	0	3
50S ribosomal protein L27	0	3	0	3
50S ribosomal protein L28	0	3	0	3
50S ribosomal protein L29	0	3	0	3
50S ribosomal protein L31	0	3	0	3
50S ribosomal protein L31 type B	0	3	0	3
50S ribosomal protein L32	0	3	0	3
50S ribosomal protein L33	0	3	0	3
50S ribosomal protein L34	0	3	0	3
50S ribosomal protein L35	0	3	0	3
50S ribosomal protein L36	0	3	0	3
30S ribosomal protein S10	0	3	0	3
30S ribosomal protein S11	0	3	0	3
30S ribosomal protein S12	0	3	0	3
30S ribosomal protein S13	0	3	0	3
30S ribosomal protein S16	0	3	0	3
30S ribosomal protein S18	0	3	0	3
30S ribosomal protein S19	0	3	0	3
30S ribosomal protein S20	0	3	0	3
30S ribosomal protein S2	0	3	0	3
30S ribosomal protein S3	0	3	0	3
30S ribosomal protein S4	0	3	0	3
30S ribosomal protein S5	0	3	0	3
30S ribosomal protein S8	0	3	0	3
30S ribosomal protein S9	0	3	0	3
50S ribosomal protein L13	0	3	0	3
50S ribosomal protein L14	0	3	0	3
50S ribosomal protein L16	0	3	0	3
50S ribosomal protein L23	0	3	0	3
30S ribosomal protein S15	0	3	0	3
50S ribosomal protein L17	0	3	0	3
50S ribosomal protein L21	0	3	0	3
50S ribosomal protein L30	0	3	0	3
50S ribosomal protein L6	0	3	0	3
30S ribosomal protein S14	0	3	0	3
30S ribosomal protein S17	0	3	0	3
30S ribosomal protein S1	0	3	0	3
50S ribosomal protein L18	0	3	0	3
50S ribosomal protein L2	0	3	0	3
50S ribosomal protein L3	0	3	0	3
50S ribosomal protein L24	0	3	0	3
50S ribosomal protein L4	0	3	0	3
50S ribosomal protein L22	0	3	0	3
50S ribosomal protein L5	0	3	0	3
30S ribosomal protein S21	0	3	0	3
50S ribosomal protein L25	0	3	0	3
50S ribosomal protein L36 2	0	3	0	3
Inositol hexakisphosphate kinase 1	2	0	0	2
Methionine--tRNA ligase, mitochondrial	0	0	1	1
cytochrome P450 2C9, partial	2	0	0	2
thioredoxin reductase	3	0	0	3
PPM1D protein	2	0	0	2
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0	1	0	1
Spike glycoprotein	0	1	1	2
Replicase polyprotein 1ab	0	2	1	3
glucose-6-phosphate 1-dehydrogenase isoform b	0	1	0	1
flap endonuclease 1	2	0	0	2
Transmembrane protease serine 2	0	1	1	2
Dihydrofolate reductase	0	2	0	2
DNA ligase	0	1	0	1
Riboflavin-binding protein	0	0	1	1
Major prion protein	0	0	1	1
Amyloid-beta precursor protein	0	1	0	1
Histidine-rich protein PFHRP-II	0	1	0	2
Procathepsin L	0	1	1	2
Muscarinic acetylcholine receptor M2	0	2	0	2
Muscarinic acetylcholine receptor M4	0	1	0	1
Muscarinic acetylcholine receptor M5	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Replicase polyprotein 1a	0	1	1	2
Replicase polyprotein 1ab	0	1	1	2
Replicase polyprotein 1ab	0	2	1	3
Spike glycoprotein	0	1	0	1
Replicase polyprotein 1ab	0	2	1	3
Muscarinic acetylcholine receptor M1	0	1	0	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	1	0	1
Alpha-2C adrenergic receptor	0	1	0	1
DNA ligase 1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	1	0	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Beta-secretase 1	0	1	0	1
Calcium-dependent protein kinase 1	0	0	1	1
MO15-related protein kinase Pfmrk	0	1	0	1
DNA ligase A	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	11	0	14
Sigma intracellular receptor 2	0	1	0	1
Phosphoethanolamine N-methyltransferase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	13	0	13
Ataxin-2	1	0	0	1
Sigma non-opioid intracellular receptor 1	0	1	0	1
Angiotensin-converting enzyme 2	0	1	1	2
Cysteine proteinase falcipain 2a	0	1	0	1
Cysteine proteinase falcipain 2a	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	4	0	0	4
Chain A, HADH2 protein	4	0	0	4
Chain B, HADH2 protein	4	0	0	4
Chain A, 2-oxoglutarate Oxygenase	4	0	0	4
Chain A, Cruzipain	1	0	0	1
cytochrome P450 2C9 precursor	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	3	0	0	3
Gamma-aminobutyric acid receptor subunit pi	2	3	0	5
Cytochrome P450 1A2	0	1	0	1
DNA gyrase subunit B	0	2	0	2
DNA gyrase subunit A	0	2	0	2
DNA gyrase subunit B	0	5	0	7
DNA gyrase subunit A	0	8	0	13
DNA gyrase subunit B	0	8	1	13
DNA topoisomerase 4 subunit A	0	2	0	2
DNA topoisomerase 4 subunit B	0	2	0	3
DNA topoisomerase 4 subunit A	0	5	0	6
Cytochrome P450 2D6	0	1	0	1
DNA topoisomerase 2-alpha	0	2	0	7
Cytochrome P450 2C9	0	4	0	4
Gamma-aminobutyric acid receptor subunit beta-1	2	3	0	5
Gamma-aminobutyric acid receptor subunit delta	2	3	0	5
Gamma-aminobutyric acid receptor subunit gamma-2	2	3	0	5
Gamma-aminobutyric acid receptor subunit alpha-5	2	3	0	5
Gamma-aminobutyric acid receptor subunit alpha-3	2	3	0	5
DNA gyrase subunit A	0	5	0	7
Gamma-aminobutyric acid receptor subunit gamma-1	2	3	0	5
Gamma-aminobutyric acid receptor subunit alpha-2	2	3	0	5
Gamma-aminobutyric acid receptor subunit alpha-4	2	3	0	5
Gamma-aminobutyric acid receptor subunit gamma-3	2	3	0	5
Gamma-aminobutyric acid receptor subunit alpha-6	2	3	0	5
Cytochrome P450 2C19	0	1	0	1
Multidrug resistance protein MdtK	0	0	2	2
Histamine H2 receptor	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	2	3	0	5
Gamma-aminobutyric acid receptor subunit beta-3	2	3	0	5
Gamma-aminobutyric acid receptor subunit beta-2	2	3	0	5
DNA gyrase subunit B	0	5	0	7
DNA gyrase subunit A	0	6	0	8
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	0	0	2
DNA topoisomerase 4 subunit A	0	2	0	2
DNA topoisomerase 4 subunit B	0	2	0	2
Integrase	0	2	0	2
GABA theta subunit	2	3	0	5
Gamma-aminobutyric acid receptor subunit epsilon	2	3	0	5
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E	0	0	1	1
retinoid X nuclear receptor alpha	5	0	0	5
peroxisome proliferator-activated receptor delta	4	0	0	4
thyroid hormone receptor beta isoform a	2	0	0	2
Beta-lactamase	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	1
GLS protein	2	0	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	2
arylsulfatase A	2	0	0	2
Metallo-beta-lactamase type 2	0	0	1	3
Metallo-beta-lactamase VIM-11	0	0	0	2
Metallo-beta-lactamase VIM-2	0	0	0	2
Beta-lactamase	0	1	0	1
Metallo-beta-lactamase VIM-19	0	0	0	2
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	1	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	2
Beta-lactamase SHV-1	0	0	0	2
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase type 2	0	0	0	1
Kappa-type opioid receptor	0	0	0	1
Beta-lactamase TEM	0	0	0	2
B2 metallo-beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-13	0	0	0	2
Metallo-beta-lactamase VIM-2	0	0	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	1	3
Beta-lactamase	0	0	0	1
Metallo-b-lactamase	0	0	0	2
Beta-lactamase IMP-1	0	0	0	2
BlaVIM-1	0	0	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	2
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	2
Histamine H3 receptor	0	0	0	2
Beta-lactamase class B VIM-2	0	0	1	3
Beta-lactamase	0	0	0	2
Beta-lactamase VIM-1	0	0	0	2
3-oxoacyl-[acyl-carrier-protein] synthase 3	0	1	0	1
Gap junction alpha-1 protein	0	1	0	1
Gap junction beta-2 protein	0	1	0	1
Acyl-protein thioesterase 1	0	1	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	1	0	0	1
CAAX prenyl protease 2 isoform 2	0	0	0	1
DNA polymerase beta	2	0	0	2
histone acetyltransferase KAT2A isoform 1	4	0	0	4
Bile salt export pump	0	2	0	2
Tubulin beta-4A chain	0	1	0	1
Tubulin beta chain	0	1	0	1
ATP-dependent translocase ABCB1	0	0	0	1
Tubulin alpha-3C chain	0	1	0	1
Tubulin alpha-1B chain	0	1	0	1
Tubulin alpha-4A chain	0	1	0	1
Tubulin beta-4B chain	0	1	0	1
Fatty-acid amide hydrolase 1	0	2	0	2
DNA primase	0	1	0	1
Tubulin beta-3 chain	0	1	0	1
Tubulin beta-2A chain	0	1	0	1
Tubulin beta-8 chain	0	1	0	1
Tubulin alpha-3E chain	0	1	0	1
Tubulin alpha-1A chain	0	1	0	1
Multidrug and toxin extrusion protein 1	0	1	0	1
Tubulin alpha-1C chain	0	1	0	1
Tubulin beta-6 chain	0	1	0	1
Tubulin beta-2B chain	0	1	0	1
Tubulin beta-1 chain	0	1	0	1
nuclear receptor subfamily 1, group I, member 3	3	0	0	3
Multidrug transporter MdfA	0	3	0	3
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
Albumin	0	0	3	3
Stromelysin-1	0	2	0	2
Matrilysin	0	1	0	1
Matrix metalloproteinase-9	0	1	0	1
Cytochrome P450 2J2	0	3	0	3
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
Protein-arginine deiminase type-4	0	7	0	7
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	2	0	2
DNA gyrase subunit B	0	2	0	2
Potassium voltage-gated channel subfamily E member 1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Potassium voltage-gated channel subfamily KQT member 1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	3	0	3
Sodium channel protein type 5 subunit alpha	0	1	0	1
SMAD family member 2	1	0	0	1
SMAD family member 3	1	0	0	1
nonstructural protein 1	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	1	0	0	1
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	2	0	0	2
thyroid stimulating hormone receptor	2	0	0	2
Caspase-7	1	0	0	1
caspase-3	1	0	0	1
importin subunit beta-1 isoform 1	1	0	0	1
snurportin-1	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
nuclear receptor ROR-gamma isoform 1	1	0	0	1
muscleblind-like protein 1 isoform 1	1	0	0	1
Pyruvate kinase PKM	0	1	0	1
USP1 protein, partial	1	0	0	1
thyroid stimulating hormone receptor	6	0	0	6
huntingtin isoform 2	1	0	0	1
neuropeptide S receptor isoform A	1	0	0	1
Chain A, Gyrase	0	0	1	1
Genome polyprotein	0	1	1	2
DNA gyrase subunit B	0	1	0	1
interferon gamma precursor	0	0	0	1
Heat shock protein HSP 90-alpha	0	0	2	2
Heat shock protein HSP 90-beta	0	1	2	4
DNA gyrase subunit B	0	1	0	1
Cell division inhibitor SulA	0	0	0	1
Heat shock protein HSP 90	0	1	0	1
Angiotensin-converting enzyme	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	1
DNA topoisomerase	0	1	0	1
Microtubule-associated proteins 1A/1B light chain 3B	0	2	1	3
Microtubule-associated proteins 1A/1B light chain 3A	0	2	1	3
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	1
Chain A, Ferritin light chain	1	0	0	1
STE24	0	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
CAAX prenyl protease	0	0	0	1
Trypsin	0	0	0	1
mitogen-activated protein kinase 1	1	0	0	1
Angiotensin-converting enzyme	0	2	0	2
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
vitamin D3 receptor isoform VDRA	1	0	0	1
glp-1 receptor, partial	2	0	0	2
transcriptional regulator ERG isoform 3	1	0	0	1
peripheral myelin protein 22	2	0	0	2
Aurora kinase A	0	1	0	1
Carbonic anhydrase 1	0	3	0	4
Carbonic anhydrase 2	0	3	1	5
Carbonic anhydrase 6	0	3	0	3
cytochrome P450 2C19 precursor	2	0	0	2
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	1	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 12	0	1	0	1
Voltage-dependent calcium channel gamma-2 subunit	1	0	0	1
Carbonic anhydrase 2	0	1	1	2
Cholinesterase	0	1	0	1
Carbonic anhydrase 3	0	1	0	1
5-hydroxytryptamine receptor 2C	0	1	0	1
5-hydroxytryptamine receptor 2A	0	2	0	2
Glutamate receptor 2	1	0	0	1
Acetylcholinesterase	0	2	0	2
Carbonic anhydrase 4	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
5-hydroxytryptamine receptor 2B	0	2	0	2
Delta-type opioid receptor	0	1	0	1
Delta-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	2	0	3
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 7	0	1	0	1
Carbonic anhydrase	0	1	0	1
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Carbonic anhydrase	0	1	0	1
Mu-type opioid receptor	0	2	0	2
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase 9	0	2	0	2
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Delta carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
Carbonic anhydrase 4	0	1	0	1
Carbonic anhydrase 15	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
Protein argonaute-2	0	0	1	1
Carbonic anhydrase 14	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	1	0	2
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
Histone H2A.x	1	0	0	1
estrogen receptor beta isoform 1	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	1	0	1
tyrosine-protein phosphatase non-receptor type 7 isoform 2	0	1	0	1
Tetracycline resistance protein, class B	0	0	0	1
72 kDa type IV collagenase	0	1	0	1
Alpha-1B adrenergic receptor	0	1	0	1
Neutrophil collagenase	0	1	0	1
Alpha-1D adrenergic receptor	0	1	0	1
Alpha-synuclein	0	1	0	1
Alpha-1A adrenergic receptor	0	1	0	1
Collagenase 3	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
Solute carrier family 22 member 8	0	0	0	1
P2Y purinoceptor 12	0	1	0	1
Solute carrier family 22 member 11	0	0	0	1
Solute carrier family 22 member 7	0	0	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
Endolysin	0	0	1	1
Chain A, Dihydrofolate Reductase	0	0	1	1
Chain A, Dihydrofolate reductase	0	1	0	1
Chain A, dihydrofolate reductase (DHFR)	0	1	0	1
Chain A, Dihydrofolate reductase	0	1	0	1
Chain A, Dihydrofolate reductase	0	1	0	1
endonuclease IV	1	0	0	1
dopamine D1 receptor	1	0	0	1
ATAD5 protein, partial	1	0	0	1
NFKB1 protein, partial	1	0	0	1
estrogen receptor 2 (ER beta)	1	0	0	1
progesterone receptor	1	0	0	1
67.9K protein	1	0	0	1
Bloom syndrome protein isoform 1	1	0	0	1
cytochrome P450 3A4 isoform 1	2	0	0	2
muscarinic acetylcholine receptor M1	1	0	0	1
Solute carrier family 22 member 1	0	1	0	1
Dihydrofolate reductase	0	1	0	2
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase type 1	0	1	0	2
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Dihydrofolate reductase	0	1	0	1
NH(3)-dependent NAD(+) synthetase	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Dihydrofolate reductase type 1 from Tn4003	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Metabotropic glutamate receptor 5	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Trace amine-associated receptor 5	0	0	1	1
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	2
Dihydrofolate reductase	0	1	0	1
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
twin arginine protein translocation system - TatA protein	0	0	0	1
Nuclear receptor ROR-gamma	1	0	0	1
TAR DNA-binding protein 43	1	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Research

Studies (38)

Protein Targets (477)

Glanders

Synonyms(1)

Research Excerpts

Overview

Research

Studies (38)

Drugs Studied (38)

Protein Targets (477)