Page last updated: 2024-08-05 15:12:01
histological dye
A dye used in microscopic or electron microscopic examination of cells and tissues to give contrast and to highlight particular features of interest, such as nuclei and cytoplasm.
ChEBI ID: 77178
Members (53)
| Member | Definition | Class |
|---|---|---|
| 3,3'-diaminobenzidine | A member of the class of biphenyls that is benzidine in which one of the hydrogens ortho to each of the amino groups has been replaced by an amino group. | 3,3'-diaminobenzidine |
| acridine orange | A member of the class of aminoacridines that is acridine carrying two dimethylamino substituents at positions 3 and 6. The hydrochloride salt is the fluorescent dye 'acridine orange', used for cell cycle determination. | acridine orange free base |
| acriflavine chloride | The 10-methochloride salt of 3,6-diaminoacridine. Note that a mixture of this compound with 3,6-diaminoacridine (proflavine) is known as acriflavine or neutral acriflavine. | 3,6-diamino-10-methylacridinium chloride |
| alcian yellow | An organic chloride salt composed of {diazenediylbis[(4,1-phenylene)(6-methyl-1,3-benzothiazole-2,5-diyl)methylenesulfanediyl]}bis[(dimethylamino)-N,N-dimethylmethaniminium] and chloride ions in a 1:2 ratio. | alcian yellow |
| alizarin red s | An organic sodium salt having 3,4-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-sulfonate as the counterion. It is commonly used to stain embryo skeletons in cleared whole mounts, usually of small mammals. | alizarin red S |
| aurintricarboxylic acid | A member of the class of quinomethanes that is 3-methylidene-6-oxocyclohexa-1,4-diene-1-carboxylic acid in which the methylidene hydrogens are replaced by 4-carboxy-3-hydroxyphenyl groups. The trisodium salt is the biological stain 'chrome violet CG' while the triammonium salt is 'aluminon'. | aurintricarboxylic acid |
| azocarmine g | An organic sodium salt having 7-phenyl-5-(4-sulfonatoanilino)benzo[a]phenazin-7-ium-3-sulfonate as the couterion. | azocarmine G |
| basic blue k | An iminium salt composed of 4-{[4-(dimethylamino)phenyl][4-(ethylamino)naphthalen-1-yl]methylidene}-N,N-dimethylcyclohexa-2,5-dien-1-iminium and chloride ions in a 1:1 ratio. | victoria blue R |
| benzophenoneidum | A hydrochloride obtained by combining 4,4'-carbonimidoylbis(N,N-dimethylaniline) with one molar equivalent of hydrogen chloride. A fluorescent stain for demonstrating acid fast organisms in a method similar to the Ziehl Neelsen. It also can be used to make a fluorescent Schiff reagent. | auramine O |
| biebrich scarlet | An organic sodium salt having 2-[(2-hydroxynaphthalen-1-yl)diazenyl]-5-[(4-sulfonatophenyl)diazenyl]benzene-1-sulfonate as the counterion. Used as a plasma stain in Masson's trichrome. | Biebrich scarlet |
| brazilin | A organic heterotetracyclic compound that is a red pigment obtained from the wood of Caesalpinia echinata (Brazil-wood) or Caesalpinia sappan (sappan-wood). | brazilin |
| brilliant crocein | An organic sodium salt that is the disodium salt of 7-hydroxy-8-{[4-(phenyldiazenyl)phenyl]diazenyl}naphthalene-1,3-disulfonic acid. Occasionally used for the demonstration of muscle fibres in conjunction with, or as a replacement for, acid fuchsin. | woodstain scarlet |
| brilliant green | An organic hydrogensulfate salt having 4-{[4-(diethylamino)phenyl](phenyl)methylidene}-N,N-diethylcyclohexa-2,5-dien-1-iminium as the counterion. | brilliant green |
| c.i. direct red 80 | An organic sodium salt resulting from the formal condensation of Sirius red F3B (acid form) with six equivalents of sodium hydroxide. A polyazo dye used principally in staining methods for collagen and amyloid. | Sirius red F3B |
| carmine | A tetrahydroxyanthraquinone that is that is 1,3,4,6-tetrahydroxy-9,10-anthraquinone substituted by a methyl group at position 8, a carboxy group at position 7 and a 1,5-anhydro-D-glucitol moiety at position 2 via a C-glycosidic linkage. It is a natural dye isolated from several insects such as Dactylopius coccus. | carminic acid |
| chromotrope 2r | An organic sodium salt that is the disodium salt of 4,5-dihydroxy-3-(phenyldiazenyl)naphthalene-2,7-disulfonic acid. It is used as the plasma stain in trichrome techniques. | acid red 29 |
| eosine i bluish | An organic sodium salt which is the disodium salt of eosin b diphenol. | eosin b |
| eosine yellowish-(ys) | An organic sodium salt that is 2',4',5',7'-tetrabromofluorescein in which the carboxy group and the phenolic hydroxy group have been deprotonated and the resulting charge is neutralised by two sodium ions. | eosin YS dye |
| ethyl violet | An organic chloride salt that is the monochloride salt of ethyl violet cation. Used for inclusion in mixed dye solutions of the iron resorcin fuchsin type for demonstrating elastic fibres. | ethyl violet |
| evans blue | An organic sodium salt that is the tetrasodium salt of 6,6'-{(3,3'-dimethyl[1,1'-biphenyl]-4,4'-diyl)bis[diazene-2,1-diyl]}bis(4-amino-5-hydroxynaphthalene-1,3-disulfonate). It is sometimes used as a counterstain, especially in fluorescent methods to suppress background autofluorescence. | Evans blue |
| fast blue b | The aromatic diazonium ion formed from diazotisation of 3,3'-dimethoxy[1,1'-biphenyl]-4,4'-diamine. | fast blue B |
| fast green fcf | An organic sodium salt having 2-{(4-{ethyl[(3-sulfonatophenyl)methyl]amino}phenyl)[4-{ethyl[(3-sulfonatophenyl)methyl]iminio}cyclohexa-2,5-dien-1-ylidene]methyl}-5-hydroxybenzene-1-sulfonate as the counterion. Used as a substitute for Light green SF yellowish in Masson's trichrome as it is less likely to fade, and is more brilliant in colour. Also used as a food colouring agent. | Fast green FCF |
| gallein | A xanthene dye that is fluoran carrying four hydroxy substituents at positions 3', 4', 5' and 6'. | gallein |
| gardenia yellow | A diester that is crocetin in which both of the carboxy groups have been converted to their gentiobiosyl esters. It is one of the water-soluble yellow-red pigments of saffron and is used as a spice for flavouring and colouring food. Note that in India, the term 'Crocin' is also used by GlaxoSmithKline as a brand-name for paracetamol. | crocin-1 |
| gentian violet | An organic chloride salt that is the monochloride salt of crystal violet cation. It has been used in creams for the topical treatment of bacterial and fungal infections, being effective against some Gram-positive bacteria (notably Staphylococcus species) and some pathogenic fungi (including Candida species) but use declined following reports of animal carcinogenicity. It has also been used for dying wood, silk, and paper, as well as a histological stain. | crystal violet |
| hematoxylin | An organic heterotetracyclic compound 7,11b-dihydroindeno[2,1-c]chromene carrying five hydroxy substituents at positions 3, 4, 6a, 9 and 10. The most important and most used dye in histology, histochemistry, histopathology and in cytology. | haematoxylin |
| iodonitrotetrazolium | An organic chloride salt having iodonitrotetrazolium as the counterion. | iodonitrotetrazolium chloride |
| light green sf | An organic sodium salt having 3-[(ethyl{4-[(4-{ethyl[(3-sulfonatophenyl)methyl]amino}phenyl)(4-sulfonatophenyl)methylidene]cyclohexa-2,5-dien-1-ylidene}azaniumyl)methyl]benzene-1-sulfonate as the counterion. It is the standard dye in North American for staining collagen and is also used extensively in plant histology. | acid green 5 |
| lissamine rhodamine b | An organic sodium salt having 4-[3,6-bis(diethylamino)xanthenium-9-yl]benzene-1,3-disulfonate as the counterion. | lissamine rhodamine |
| malachite green | An organic chloride salt that is the monochloride salt of malachite green cation. Used as a green-coloured dye, as a counter-stain in histology, and for its anti-fungal properties in aquaculture. | malachite green |
| metanil yellow | An organic sodium salt having 3-[(4-anilinophenyl)diazenyl]benzene-1-sulfonate as the counterion. Used in one variant of Masson's trichrome to stain collagen yellow in contrast to the red muscle, but is not in common used. | metanil yellow |
| methylene blue | An organic chloride salt having 3,7-bis(dimethylamino)phenothiazin-5-ium as the counterion. A commonly used dye that also exhibits antioxidant, antimalarial, antidepressant and cardioprotective properties. | methylene blue |
| methylene green | An organic chloride salt having 3,7-bis(dimethylamino)-4-nitrophenothiazin-5-ium as the counterion. It stains nuclei green and is sometimes used as a counterstain to red or purple primary stains. | methylene green |
| naphthol yellow | A naphthalenesulfonic acid that is naphthalene-2-sulfonic acid substituted by nitro groups at positions 5 and 7 as well as a hydroxy group at position 8. The disodium salt is the biological stain 'naphthol yellow S'. | flavianic acid |
| new fuchsin | A hydrochloride that is the monohydrochloride of 4-[(4-aminophenyl)(4-iminocyclohexa-2,5-dien-1-ylidene)methyl]-2-methylaniline. One of the minor constituents of Basic fuchsin, together with pararosanilin, rosanilin and magenta II. | new fuchsin |
| nile red | An organic heterotetracyclic compound that is 5H-benzo[a]phenoxazin-5-one substituted at position 9 by a diethylamino group. | nile red |
| nuclear fast red | An organic sodium salt that is the monosodium salt of 4-amino-1,3-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-sulfonic acid. It forms bright red lakes with calcium and is a useful red nuclear staining lake with aluminum. | nuclear fast red |
| osmium tetroxide | An osmium coordination entity consisting of four oxygen atoms bound to a central osmium atom via covalent double bonds. | osmium tetroxide |
| phenosafranine | An organic chloride salt having 3,7-diamino-5-phenylphenazin-5-ium as the counterion. It is commonly used for staining Gram negative bacteria red in smears to contrast with the blue Gram positive organisms. | phenosafranine |
| ponceau s | An organic sodium salt that is the tetrasodium salt of 3-hydroxy-4-({2-sulfo-4-[(4-sulfophenyl)diazenyl]phenyl}diazenyl)naphthalene-2,7-disulfonic acid. | Ponceau S |
| primuline | An organic sodium salt having 2'-(4-aminophenyl)-6-methyl[2,6'-bi-1,3-benzothiazole]-7-sulfonate as the counterion. | primuline |
| purpurin | A trihydroxyanthraquinone derived from anthracene by substitution with oxo groups at C-9 and C-10 and with hydroxy groups at C-1, C-2 and C-4. | purpurin |
| pyronine | An organic chloride salt having 6-(dimethylamino)-N,N-dimethyl-3H-xanthen-3-iminium as the cation. Used with methyl green to selectively demonstrate RNA (red) in contrast to DNA (green) with the Unna-Pappenheim method. | pyronin Y |
| pyronine b | An organic chloride salt having 6-(diethylamino)-N,N-diethyl-3H-xanthen-3-iminium as the cation. Depending on the mode of manufacture, pyronin B also exists in the form of an FeCl3 complex. | pyronin B |
| red 2g | An organic sodium salt that is the disodium salt of 5-acetamido-4-hydroxy-3-(phenyldiazenyl)naphthalene-2,7-disulfonic acid. | azophloxine |
| rhodamine b | An organic chloride salt having N-[9-(2-carboxyphenyl)-6-(diethylamino)-3H-xanthen-3-ylidene]-N-ethylethanaminium as the counterion. An amphoteric dye commonly used as a fluorochrome. | rhodamine B |
| safranine t | An organic chloride salt having 3,7-diamino-2,8-dimethyl-5-phenylphenazin-5-ium as the counterion. It is commonly used for staining Gram negative bacteria. | safranin O |
| scarlet red | A bis(azo) compound that is 2-naphthol substituted at position 1 by a {2-methyl-4-[(2-methylphenyl)diazenyl]phenyl}diazenyl group. A fat-soluble dye predominantly used for demonstrating triglycerides in frozen sections, but which may also stain some protein bound lipids in paraffin sections. | Sudan IV |
| sudan black b | A member of the class of perimidines that is 2,2-dimethyl-2,3-dihydro-1H-perimidine carrying a [4-(phenyldiazenyl)naphthalen-1-yl]diazenyl substituent at position 6. A fat-soluble dye predominantly used for demonstrating triglycerides in frozen sections and for staining of protein bound lipids in paraffin sections. | Sudan black B |
| sudan iii | A bis(azo) compound that is 2-naphthol substituted at position 1 by a 4-{[(2-methylphenyl)diazenyl]phenyl}diazenyl group. A fat-soluble dye predominantly used for demonstrating triglycerides in frozen sections, but which may also stain some protein bound lipids in paraffin sections. | Sudan III |
| thioflavin t | An organic chloride salt having 2-[4-(dimethylamino)phenyl]-3,6-dimethyl-1,3-benzothiazol-3-ium as the counterion. It is widely used to visualise and quantify the presence of amyloids, both in vitro and in vivo. | thioflavine T |
| victoria blue 4r | An iminium salt composed of 4-([4-(dimethylamino)phenyl]{4-[methyl(phenyl)amino]naphthalen-1-yl}methylidene)-N,N-dimethylcyclohexa-2,5-dien-1-iminium and chloride ions in a 1:1 ratio. It binds to nucleic acids and can be used in standardised staining techniques suitable for automated cell-pattern recognition. | victoria blue 4R |
| victoria blue b | An iminium salt composed of 4-{(4-anilinonaphthalen-1-yl)[4-(dimethylamino)phenyl]methylidene}-N,N-dimethylcyclohexa-2,5-dien-1-iminium and chloride ions in a 1:1 ratio. It binds to nucleic acids and can be used in standardised staining techniques suitable for automated cell-pattern recognition. | victoria blue B |
Research
Studies (29,038)
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 6,808 (23.45) | 18.7374 |
| 1990's | 4,320 (14.88) | 18.2507 |
| 2000's | 5,959 (20.52) | 29.6817 |
| 2010's | 8,557 (29.47) | 24.3611 |
| 2020's | 3,394 (11.69) | 2.80 |
Study Types
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 600 (1.79%) | 5.53% |
| Reviews | 796 (2.38%) | 6.00% |
| Case Studies | 1,299 (3.88%) | 4.05% |
| Observational | 40 (0.12%) | 0.25% |
| Other | 30,765 (91.84%) | 84.16% |
Protein Targets (378)
Potency Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 11.6746 | 1 | 6 |
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 6.6330 | 1 | 6 |
| 2,3-bisphosphoglycerate-independent phosphoglycerate mutase | Leishmania major strain Friedlin | Potency | 30.1313 | 1 | 1 |
| 67.9K protein | Vaccinia virus | Potency | 11.1687 | 2 | 15 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 34.4934 | 4 | 32 |
| acid sphingomyelinase | Homo sapiens (human) | Potency | 24.9054 | 1 | 2 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 25.5421 | 1 | 5 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 25.6297 | 1 | 7 |
| alpha synuclein, partial | Homo sapiens (human) | Potency | 0.1515 | 1 | 1 |
| Alpha-synuclein | Homo sapiens (human) | Potency | 8.6006 | 1 | 5 |
| apical membrane antigen 1, AMA1 | Plasmodium falciparum 3D7 | Potency | 10.1866 | 1 | 4 |
| AR protein | Homo sapiens (human) | Potency | 20.1709 | 10 | 99 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 5.3257 | 2 | 20 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 7.2796 | 3 | 5 |
| Ataxin-2 | Homo sapiens (human) | Potency | 10.7704 | 1 | 7 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 8.3152 | 5 | 7 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 8.7033 | 2 | 9 |
| beta-amyloid peptide, A beta {N-terminal} [human, cerebrospinal fluid, conditioned medium of mixed-brain cell cultures, Peptide Partial, 33 aa] | Homo sapiens (human) | Potency | 0.1500 | 1 | 1 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 11.9758 | 4 | 9 |
| BRCA1 | Homo sapiens (human) | Potency | 1.4433 | 1 | 2 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 25.8051 | 1 | 5 |
| C-terminal-binding protein 1 | Homo sapiens (human) | Potency | 3.3814 | 1 | 1 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 14.1615 | 1 | 7 |
| caspase-1 isoform alpha precursor | Homo sapiens (human) | Potency | 3.9811 | 1 | 1 |
| caspase-3 | Cricetulus griseus (Chinese hamster) | Potency | 6.3829 | 1 | 4 |
| caspase-3 | Homo sapiens (human) | Potency | 14.1615 | 1 | 7 |
| Caspase-7 | Cricetulus griseus (Chinese hamster) | Potency | 6.3829 | 1 | 4 |
| Caspase-7 | Homo sapiens (human) | Potency | 3.1623 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 23.7676 | 3 | 19 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 17.7994 | 2 | 5 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 20.5589 | 1 | 9 |
| Chain A, ATP-DEPENDENT DNA HELICASE Q1 | Homo sapiens (human) | Potency | 14.7323 | 4 | 12 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 8.9125 | 2 | 2 |
| Chain A, Breast cancer type 1 susceptibility protein | Homo sapiens (human) | Potency | 21.8637 | 2 | 5 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 22.1777 | 2 | 6 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 43.2541 | 2 | 5 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 4.5186 | 2 | 6 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 25.8603 | 1 | 8 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 12.2230 | 3 | 16 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 18.4876 | 1 | 8 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 7.3463 | 2 | 15 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 4.5186 | 2 | 6 |
| chaperonin-containing TCP-1 beta subunit homolog | Homo sapiens (human) | Potency | 46.5909 | 1 | 2 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 18.3261 | 2 | 8 |
| ClpP | Bacillus subtilis | Potency | 21.6712 | 1 | 1 |
| core-binding factor subunit beta isoform 2 | Homo sapiens (human) | Potency | 4.8608 | 2 | 2 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 13.1289 | 1 | 5 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 17.3045 | 1 | 4 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 20.2495 | 2 | 14 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 10.8041 | 2 | 7 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 23.7053 | 1 | 17 |
| Disintegrin and metalloproteinase domain-containing protein 17 | Homo sapiens (human) | Potency | 10.1945 | 1 | 3 |
| DNA dC->dU-editing enzyme APOBEC-3F isoform a | Homo sapiens (human) | Potency | 14.3331 | 2 | 5 |
| DNA dC->dU-editing enzyme APOBEC-3G isoform 1 | Homo sapiens (human) | Potency | 20.5962 | 1 | 1 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 10.5485 | 1 | 5 |
| DNA polymerase eta isoform 1 | Homo sapiens (human) | Potency | 35.3652 | 2 | 11 |
| DNA polymerase III, partial | Bacillus subtilis | Potency | 3.3587 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 32.6605 | 2 | 13 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 23.3203 | 2 | 19 |
| endonuclease IV | Escherichia coli | Potency | 1.4733 | 2 | 2 |
| Endothelin receptor type B | Rattus norvegicus (Norway rat) | Potency | 12.3807 | 1 | 2 |
| Endothelin-1 receptor | Rattus norvegicus (Norway rat) | Potency | 12.3807 | 1 | 2 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 22.0710 | 12 | 126 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 44.4379 | 2 | 11 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 16.4590 | 7 | 87 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 15.9620 | 1 | 11 |
| eyes absent homolog 2 isoform a | Homo sapiens (human) | Potency | 46.1888 | 2 | 4 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 36.0960 | 4 | 15 |
| Fatty-acid amide hydrolase 1 | Rattus norvegicus (Norway rat) | Potency | 44.6684 | 1 | 1 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 32.0013 | 3 | 16 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 17.7828 | 1 | 1 |
| G | Vesicular stomatitis virus | Potency | 13.1289 | 1 | 5 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 20.2495 | 1 | 7 |
| galactokinase | Homo sapiens (human) | Potency | 14.1254 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 20.2495 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 20.2495 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 20.2495 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 20.2495 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 20.2495 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 20.2495 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 20.2495 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 20.2495 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 20.2495 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 20.2495 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 20.2495 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 20.2495 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 20.2495 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 20.2495 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 20.2495 | 1 | 7 |
| geminin | Homo sapiens (human) | Potency | 12.4619 | 3 | 12 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 11.3801 | 3 | 23 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 5.8223 | 1 | 4 |
| GLS protein | Homo sapiens (human) | Potency | 8.7524 | 2 | 5 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 20.4030 | 6 | 8 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 22.1357 | 4 | 18 |
| glucokinase regulatory protein | Homo sapiens (human) | Potency | 10.6992 | 3 | 3 |
| Glutamate receptor 1 | Rattus norvegicus (Norway rat) | Potency | 3.1829 | 1 | 2 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 21.0384 | 2 | 18 |
| Glutamate receptor 3 | Rattus norvegicus (Norway rat) | Potency | 3.1829 | 1 | 2 |
| Glutamate receptor 4 | Rattus norvegicus (Norway rat) | Potency | 3.1829 | 1 | 2 |
| Glutamate receptor ionotropic, kainate 1 | Rattus norvegicus (Norway rat) | Potency | 0.1515 | 1 | 1 |
| Glutamate receptor ionotropic, kainate 2 | Rattus norvegicus (Norway rat) | Potency | 0.1515 | 1 | 1 |
| Glutamate receptor ionotropic, kainate 3 | Rattus norvegicus (Norway rat) | Potency | 0.1515 | 1 | 1 |
| Glutamate receptor ionotropic, kainate 4 | Rattus norvegicus (Norway rat) | Potency | 0.1515 | 1 | 1 |
| Glutamate receptor ionotropic, kainate 5 | Rattus norvegicus (Norway rat) | Potency | 0.1515 | 1 | 1 |
| Glycoprotein hormones alpha chain | Homo sapiens (human) | Potency | 16.9320 | 1 | 4 |
| GTP-binding nuclear protein Ran isoform 1 | Homo sapiens (human) | Potency | 16.4131 | 1 | 2 |
| Guanine nucleotide-binding protein G | Homo sapiens (human) | Potency | 24.4917 | 2 | 7 |
| guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1 | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 29.6385 | 2 | 10 |
| hemoglobin subunit beta | Homo sapiens (human) | Potency | 12.2155 | 3 | 3 |
| hexokinase-4 isoform 1 | Homo sapiens (human) | Potency | 10.6992 | 3 | 3 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 16.7051 | 2 | 11 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 16.6811 | 1 | 7 |
| histone deacetylase 9 isoform 3 | Homo sapiens (human) | Potency | 22.6170 | 2 | 21 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 42.8083 | 2 | 32 |
| histone-lysine N-methyltransferase 2A isoform 2 precursor | Homo sapiens (human) | Potency | 20.9722 | 1 | 4 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 13.1289 | 1 | 5 |
| huntingtin isoform 2 | Homo sapiens (human) | Potency | 9.0187 | 1 | 3 |
| hypothetical protein, conserved | Trypanosoma brucei | Potency | 16.9783 | 3 | 8 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 31.4771 | 2 | 11 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 13.6758 | 3 | 3 |
| IDH1 | Homo sapiens (human) | Potency | 8.0026 | 1 | 6 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 39.0826 | 2 | 5 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 13.1289 | 1 | 10 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 9.2601 | 2 | 8 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 22.1060 | 1 | 2 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 22.1060 | 1 | 2 |
| Interferon beta | Homo sapiens (human) | Potency | 22.2018 | 3 | 13 |
| interleukin 8 | Homo sapiens (human) | Potency | 66.8242 | 1 | 1 |
| isocitrate dehydrogenase 1, partial | Homo sapiens (human) | Potency | 24.2836 | 1 | 3 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 20.0850 | 1 | 2 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 12.8127 | 1 | 3 |
| lethal(3)malignant brain tumor-like protein 1 isoform I | Homo sapiens (human) | Potency | 16.3190 | 1 | 5 |
| Leukotriene B4 receptor 1 | Homo sapiens (human) | Potency | 0.1800 | 1 | 1 |
| Leukotriene B4 receptor 2 | Homo sapiens (human) | Potency | 0.1800 | 1 | 1 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 27.3965 | 3 | 25 |
| luciferase | Photuris pensylvanica (Pennsylania firefly) | Potency | 9.2004 | 1 | 3 |
| luteinizing hormone receptor | Homo sapiens (human) | Potency | 84.9214 | 1 | 1 |
| lysosomal alpha-glucosidase preproprotein | Homo sapiens (human) | Potency | 3.1623 | 1 | 1 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 0.2078 | 1 | 2 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 15.5502 | 3 | 18 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 15.4881 | 2 | 11 |
| muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 1.3972 | 1 | 3 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 3.1824 | 3 | 3 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 4.4668 | 1 | 1 |
| NPC intracellular cholesterol transporter 1 precursor | Homo sapiens (human) | Potency | 0.5623 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 15.4731 | 4 | 28 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 11.7006 | 2 | 8 |
| nuclear factor NF-kappa-B p105 subunit isoform 1 | Homo sapiens (human) | Potency | 40.5174 | 1 | 3 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 42.6930 | 1 | 5 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 3.8395 | 1 | 2 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 13.3539 | 2 | 9 |
| nuclear receptor subfamily 1, group I, member 2 | Rattus norvegicus (Norway rat) | Potency | 5.0119 | 1 | 1 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 28.0181 | 3 | 44 |
| Ornithine decarboxylase | Rattus norvegicus (Norway rat) | Potency | 0.1585 | 1 | 1 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 29.8816 | 1 | 2 |
| peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 28.9541 | 4 | 10 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 4.9487 | 2 | 4 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 67.4555 | 1 | 1 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 30.0030 | 5 | 17 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 36.2068 | 5 | 17 |
| phosphoglycerate kinase | Trypanosoma brucei brucei TREU927 | Potency | 14.6383 | 3 | 9 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 62.2386 | 3 | 6 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 1.5855 | 1 | 3 |
| Platelet-activating factor receptor | Homo sapiens (human) | Potency | 39.8107 | 1 | 2 |
| polyprotein | Zika virus | Potency | 17.7828 | 1 | 1 |
| polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | Potency | 15.4637 | 1 | 3 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 17.0262 | 1 | 4 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 12.8127 | 1 | 3 |
| PPM1D protein | Homo sapiens (human) | Potency | 30.0503 | 1 | 4 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 8.7636 | 3 | 13 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 19.6493 | 1 | 3 |
| progesterone receptor | Homo sapiens (human) | Potency | 36.9070 | 2 | 15 |
| pyruvate kinase | Leishmania mexicana mexicana | Potency | 12.3807 | 2 | 4 |
| pyruvate kinase PKM isoform a | Homo sapiens (human) | Potency | 39.8107 | 2 | 2 |
| pyruvate kinase PKM isoform b | Homo sapiens (human) | Potency | 0.1585 | 2 | 2 |
| Rap guanine nucleotide exchange factor 3 | Homo sapiens (human) | Potency | 55.3068 | 2 | 8 |
| Rap guanine nucleotide exchange factor 4 | Homo sapiens (human) | Potency | 70.3796 | 2 | 5 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 18.5527 | 2 | 29 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 3.3727 | 1 | 2 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 46.4564 | 1 | 5 |
| relaxin receptor 1 isoform 1 | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 16.1667 | 3 | 36 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 14.5412 | 4 | 21 |
| RGS12 | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| runt-related transcription factor 1 isoform AML1b | Homo sapiens (human) | Potency | 4.8608 | 2 | 2 |
| serine-protein kinase ATM isoform a | Homo sapiens (human) | Potency | 17.5169 | 4 | 5 |
| serine/threonine-protein kinase PLK1 | Homo sapiens (human) | Potency | 15.8764 | 1 | 6 |
| Single-stranded DNA cytosine deaminase | Homo sapiens (human) | Potency | 79.3735 | 2 | 4 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 32.8274 | 2 | 10 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 32.8274 | 2 | 10 |
| Smad3 | Homo sapiens (human) | Potency | 14.0460 | 1 | 5 |
| snurportin-1 | Homo sapiens (human) | Potency | 39.0826 | 2 | 5 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 20.6542 | 1 | 4 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 8.4494 | 1 | 7 |
| T cell receptor, partial | Homo sapiens (human) | Potency | 4.0276 | 1 | 2 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 13.2520 | 1 | 5 |
| TDP1 protein | Homo sapiens (human) | Potency | 11.4908 | 2 | 36 |
| thioredoxin glutathione reductase | Schistosoma mansoni | Potency | 29.5216 | 1 | 3 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 26.3288 | 2 | 8 |
| Thrombopoietin | Homo sapiens (human) | Potency | 3.1623 | 2 | 2 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 22.6752 | 3 | 39 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 32.1544 | 4 | 11 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 31.3277 | 7 | 63 |
| thyrotropin-releasing hormone receptor | Homo sapiens (human) | Potency | 16.2315 | 3 | 8 |
| transcriptional regulator ERG isoform 3 | Homo sapiens (human) | Potency | 18.1930 | 1 | 3 |
| TSHR protein | Homo sapiens (human) | Potency | 15.5035 | 2 | 2 |
| tumor necrosis factor | Homo sapiens (human) | Potency | 42.1632 | 1 | 1 |
| tumor susceptibility gene 101 protein | Homo sapiens (human) | Potency | 33.6365 | 3 | 8 |
| ubiquitin carboxyl-terminal hydrolase 2 isoform a | Homo sapiens (human) | Potency | 7.8837 | 3 | 7 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 1.5855 | 1 | 3 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 1.5855 | 1 | 3 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 36.1438 | 2 | 11 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 18.7587 | 2 | 17 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 31.7793 | 3 | 12 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 30.8507 | 1 | 12 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 23.2703 | 1 | 16 |
| Vpr | Human immunodeficiency virus 1 | Potency | 22.3143 | 1 | 7 |
| WRN | Homo sapiens (human) | Potency | 29.1669 | 2 | 8 |
Inhibition Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 10 kDa chaperonin | Escherichia coli | IC50 | 5.8245 | 2 | 8 |
| 10 kDa heat shock protein, mitochondrial | Homo sapiens (human) | IC50 | 8.0425 | 1 | 4 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | IC50 | 2.6270 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | Ki | 0.7510 | 1 | 1 |
| 60 kDa chaperonin | Escherichia coli K-12 | IC50 | 227.7500 | 1 | 4 |
| 60 kDa chaperonin | Escherichia coli | IC50 | 5.8245 | 2 | 8 |
| 60 kDa heat shock protein, mitochondrial | Homo sapiens (human) | IC50 | 8.0425 | 1 | 4 |
| Acetylcholinesterase | Homo sapiens (human) | IC50 | 5.8470 | 1 | 1 |
| Adenosine receptor A2a | Homo sapiens (human) | IC50 | 3.3650 | 1 | 1 |
| Adenosine receptor A2a | Homo sapiens (human) | Ki | 1.8890 | 1 | 1 |
| Adenosine receptor A3 | Homo sapiens (human) | IC50 | 4.1660 | 1 | 1 |
| Adenosine receptor A3 | Homo sapiens (human) | Ki | 2.3550 | 1 | 1 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 2.3330 | 2 | 2 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 2.3550 | 1 | 1 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 2.3330 | 2 | 2 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 2.3550 | 1 | 1 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | IC50 | 1.9800 | 1 | 1 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.5000 | 1 | 1 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | Ki | 0.9730 | 1 | 1 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | IC50 | 0.5360 | 1 | 1 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | Ki | 0.2010 | 1 | 1 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | IC50 | 1.2580 | 1 | 1 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | Ki | 0.5740 | 1 | 1 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | IC50 | 1.8840 | 1 | 1 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | Ki | 0.2740 | 1 | 1 |
| Amine oxidase [flavin-containing] A | Homo sapiens (human) | IC50 | 30.9267 | 6 | 6 |
| Amine oxidase [flavin-containing] A | Homo sapiens (human) | Ki | 0.4220 | 1 | 1 |
| Amine oxidase [flavin-containing] B | Homo sapiens (human) | IC50 | 62.0500 | 4 | 4 |
| Amyloid-beta precursor protein | Homo sapiens (human) | IC50 | 0.5500 | 2 | 2 |
| Amyloid-beta precursor protein | Homo sapiens (human) | Ki | 0.9633 | 6 | 6 |
| Androgen receptor | Rattus norvegicus (Norway rat) | IC50 | 5.5700 | 1 | 1 |
| Androgen receptor | Rattus norvegicus (Norway rat) | Ki | 3.7130 | 1 | 1 |
| Apoptotic peptidase activating factor 1 | Homo sapiens (human) | IC50 | 49.8750 | 2 | 4 |
| B1 bradykinin receptor | Homo sapiens (human) | IC50 | 59.6400 | 1 | 1 |
| bcr | Homo sapiens (human) | IC50 | 35.0700 | 1 | 1 |
| Beta lactamase (plasmid) | Pseudomonas aeruginosa | IC50 | 35.2225 | 2 | 2 |
| caspase recruitment domain family, member 15 | Homo sapiens (human) | IC50 | 10.8950 | 1 | 1 |
| caspase-3 isoform a preproprotein | Homo sapiens (human) | IC50 | 16.9000 | 1 | 2 |
| caspase-9 isoform alpha precursor | Homo sapiens (human) | IC50 | 16.9000 | 1 | 2 |
| Chain A, RNA-directed RNA polymerase NS5 | Dengue virus 2 16681-PDK53 | IC50 | 17.3600 | 1 | 1 |
| Chain E, Fibrin beta chain | Homo sapiens (human) | IC50 | 46.2885 | 2 | 4 |
| Cholinesterase | Homo sapiens (human) | Ki | 0.8000 | 1 | 1 |
| Complement component C9 | Homo sapiens (human) | IC50 | 0.5000 | 1 | 1 |
| core protein, partial | IC50 | 49.7510 | 1 | 1 | |
| Cruzipain | Trypanosoma cruzi | IC50 | 55.2500 | 4 | 4 |
| Cystathionine beta-synthase | Homo sapiens (human) | IC50 | 181.8000 | 4 | 4 |
| Cystathionine gamma-lyase | Homo sapiens (human) | IC50 | 94.5000 | 10 | 10 |
| Cystathionine gamma-lyase | Mus musculus (house mouse) | IC50 | 43.2000 | 1 | 1 |
| Cystathionine gamma-lyase | Homo sapiens (human) | Ki | 0.6000 | 1 | 1 |
| Cysteine protease ATG4B | Homo sapiens (human) | IC50 | 10.4750 | 4 | 4 |
| Cytochrome P450 1A1 | Homo sapiens (human) | IC50 | 5.5000 | 1 | 1 |
| Cytochrome P450 1B1 | Homo sapiens (human) | IC50 | 2.2000 | 1 | 1 |
| Cytochrome P450 1B1 | Homo sapiens (human) | Ki | 0.7000 | 1 | 1 |
| Cytochrome P450 2D6 | Homo sapiens (human) | IC50 | 0.8244 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 3.6337 | 1 | 1 |
| D(1A) dopamine receptor | Homo sapiens (human) | IC50 | 3.1020 | 1 | 1 |
| D(1A) dopamine receptor | Homo sapiens (human) | Ki | 1.5510 | 1 | 1 |
| D(2) dopamine receptor | Homo sapiens (human) | IC50 | 3.1780 | 1 | 1 |
| D(2) dopamine receptor | Homo sapiens (human) | Ki | 1.0590 | 1 | 1 |
| D(3) dopamine receptor | Homo sapiens (human) | IC50 | 0.8310 | 1 | 1 |
| D(3) dopamine receptor | Homo sapiens (human) | Ki | 0.2820 | 1 | 1 |
| Delta-type opioid receptor | Rattus norvegicus (Norway rat) | IC50 | 1.8000 | 1 | 1 |
| Dihydrolipoyl dehydrogenase | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 1,000.0000 | 1 | 1 |
| Dihydrolipoyl dehydrogenase, mitochondrial | Sus scrofa (pig) | IC50 | 1,000.0000 | 1 | 1 |
| DNA dC->dU-editing enzyme APOBEC-3G isoform 1 | Homo sapiens (human) | IC50 | 0.4600 | 1 | 1 |
| DNA polymerase eta | Homo sapiens (human) | IC50 | 0.0750 | 1 | 1 |
| DNA polymerase iota | Homo sapiens (human) | IC50 | 0.0750 | 1 | 1 |
| DNA repair protein RAD52 homolog | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| DNA-(apurinic or apyrimidinic site) endonuclease | Homo sapiens (human) | IC50 | 3.3700 | 3 | 3 |
| DNA-3-methyladenine glycosylase | Homo sapiens (human) | IC50 | 0.2000 | 1 | 1 |
| Dual specificity mitogen-activated protein kinase kinase 3 | Homo sapiens (human) | IC50 | 14.0600 | 1 | 1 |
| Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 | Homo sapiens (human) | IC50 | 0.9220 | 1 | 1 |
| Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 | Homo sapiens (human) | Ki | 0.8240 | 1 | 1 |
| Epidermal growth factor receptor | Homo sapiens (human) | IC50 | 0.4730 | 1 | 1 |
| Female germline-specific tumor suppressor gld-1 | Caenorhabditis elegans | IC50 | 6.6880 | 1 | 1 |
| glucose-6-phosphate 1-dehydrogenase isoform b | Homo sapiens (human) | IC50 | 55.6000 | 1 | 2 |
| glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase | Plasmodium berghei | IC50 | 21.0233 | 3 | 6 |
| Glutathione reductase | Plasmodium falciparum 3D7 | IC50 | 6.4000 | 1 | 1 |
| Glutathione reductase, mitochondrial | Homo sapiens (human) | IC50 | 16.2000 | 2 | 2 |
| Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | Homo sapiens (human) | IC50 | 0.2000 | 1 | 1 |
| Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | Homo sapiens (human) | IC50 | 0.2000 | 1 | 1 |
| Histamine H2 receptor | Homo sapiens (human) | IC50 | 1.1550 | 1 | 1 |
| Histamine H2 receptor | Homo sapiens (human) | Ki | 1.1360 | 1 | 1 |
| Hypoxia-inducible factor 1-alpha | Homo sapiens (human) | IC50 | 1.0000 | 1 | 1 |
| Inhibitor of nuclear factor kappa-B kinase subunit beta | Homo sapiens (human) | IC50 | 5.4000 | 1 | 1 |
| integrase, partial | Human immunodeficiency virus 1 | IC50 | 19.2405 | 2 | 2 |
| Kappa-type opioid receptor | Cavia porcellus (domestic guinea pig) | IC50 | 282.9000 | 1 | 1 |
| Kappa-type opioid receptor | Homo sapiens (human) | IC50 | 1.5400 | 1 | 1 |
| Kappa-type opioid receptor | Homo sapiens (human) | Ki | 0.6160 | 1 | 1 |
| large T antigen | Betapolyomavirus macacae | IC50 | 3.2950 | 1 | 2 |
| lens epithelium-derived growth factor p75 | Homo sapiens (human) | IC50 | 19.2405 | 2 | 2 |
| Luciferin 4-monooxygenase | Photinus pyralis (common eastern firefly) | IC50 | 11.0400 | 5 | 5 |
| major prion protein preproprotein Prp precursor | Homo sapiens (human) | IC50 | 13.9560 | 1 | 1 |
| matrix metalloproteinase-14 preproprotein | Homo sapiens (human) | IC50 | 43.3667 | 2 | 3 |
| Mcl-1 | Homo sapiens (human) | IC50 | 3.4393 | 1 | 1 |
| metallo beta-lactamase | Pseudomonas aeruginosa | IC50 | 59.6400 | 1 | 1 |
| metallo-beta-lactamase IMP-1 | Pseudomonas aeruginosa | IC50 | 59.6400 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | IC50 | 9.4250 | 4 | 4 |
| MPI protein | Homo sapiens (human) | IC50 | 26.3740 | 1 | 1 |
| Mu-type opioid receptor | Homo sapiens (human) | IC50 | 2.1450 | 1 | 1 |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | IC50 | 3.3000 | 1 | 1 |
| Mu-type opioid receptor | Homo sapiens (human) | Ki | 0.8710 | 1 | 1 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | IC50 | 1.0950 | 1 | 1 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | Ki | 500.1320 | 2 | 2 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | IC50 | 1.4300 | 1 | 1 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | Ki | 0.5080 | 1 | 1 |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | IC50 | 4.3300 | 1 | 1 |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | Ki | 0.9180 | 1 | 1 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | IC50 | 1.0050 | 1 | 1 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | Ki | 0.1400 | 1 | 1 |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | IC50 | 0.5350 | 1 | 1 |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | Ki | 0.3840 | 1 | 1 |
| Myc proto-oncogene protein | Homo sapiens (human) | IC50 | 14.0600 | 1 | 1 |
| neutrophil cytosol factor 1 | Homo sapiens (human) | IC50 | 0.3900 | 1 | 1 |
| nonstructural protein 1 | Influenza A virus (A/California/07/2009(H1N1)) | IC50 | 13.8235 | 1 | 2 |
| nuclear receptor corepressor 2 isoform 2 | Homo sapiens (human) | IC50 | 1.0250 | 1 | 1 |
| peroxisome proliferator-activated receptor gamma isoform 2 | Homo sapiens (human) | IC50 | 1.0250 | 1 | 1 |
| Phosphoglycerate mutase 1 | Homo sapiens (human) | IC50 | 2.3000 | 1 | 1 |
| phospholipase A2, group III | Homo sapiens (human) | IC50 | 40.5870 | 1 | 1 |
| photoreceptor-specific nuclear receptor | Homo sapiens (human) | IC50 | 39.8410 | 1 | 2 |
| Polyphenol oxidase 2 | Agaricus bisporus | IC50 | 140.0000 | 1 | 1 |
| putative polyprotein | IC50 | 16.6695 | 2 | 2 | |
| Pyruvate kinase PKLR | Homo sapiens (human) | IC50 | 0.2000 | 1 | 1 |
| Pyruvate kinase PKM | Homo sapiens (human) | IC50 | 340.0000 | 1 | 1 |
| rac GTPase-activating protein 1 isoform a | Homo sapiens (human) | IC50 | 36.4833 | 2 | 3 |
| receptor-interacting serine/threonine-protein kinase 2 isoform 1 | Homo sapiens (human) | IC50 | 10.8950 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | IC50 | 4.9800 | 1 | 1 |
| Rev | Human immunodeficiency virus 1 | IC50 | 75.4340 | 1 | 1 |
| Reverse transcriptase/RNaseH | Human immunodeficiency virus 1 | IC50 | 200.0000 | 1 | 1 |
| rho GTPase-activating protein 1 | Homo sapiens (human) | IC50 | 22.0800 | 1 | 1 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | IC50 | 4.0690 | 1 | 1 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | Ki | 3.2330 | 1 | 1 |
| Substance-K receptor | Homo sapiens (human) | IC50 | 1.6790 | 1 | 1 |
| Substance-K receptor | Homo sapiens (human) | Ki | 0.5600 | 1 | 1 |
| Tat | Human immunodeficiency virus 1 | IC50 | 11.6960 | 1 | 1 |
| Telomerase reverse transcriptase | Homo sapiens (human) | IC50 | 12.2000 | 3 | 3 |
| Thioredoxin reductase 1, cytoplasmic | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |
| Thiosulfate sulfurtransferase | Homo sapiens (human) | IC50 | 31.7500 | 1 | 4 |
| Transthyretin | Homo sapiens (human) | IC50 | 11.5000 | 1 | 2 |
| Tyrosine-protein kinase Fyn | Homo sapiens (human) | IC50 | 2.1480 | 1 | 1 |
| Tyrosine-protein phosphatase 1 | Saccharomyces cerevisiae S288C | IC50 | 24.6000 | 1 | 2 |
| Tyrosine-protein phosphatase non-receptor type 1 | Homo sapiens (human) | IC50 | 20.6500 | 1 | 2 |
| Tyrosyl-DNA phosphodiesterase 1 | Homo sapiens (human) | IC50 | 0.0170 | 2 | 2 |
| Vesicular glutamate transporter 3 | Rattus norvegicus (Norway rat) | Ki | 0.0400 | 1 | 1 |
| Vif | Human immunodeficiency virus 1 | IC50 | 0.4600 | 1 | 1 |
Activation Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Albumin | Homo sapiens (human) | Kd | 2.5000 | 1 | 1 |
| alkaline phosphatase, germ cell type preproprotein | Homo sapiens (human) | EC50 | 60.4000 | 1 | 1 |
| alkaline phosphatase, intestinal | Homo sapiens (human) | EC50 | 50.0000 | 1 | 1 |
| alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein | Homo sapiens (human) | EC50 | 85.7000 | 1 | 1 |
| Cystathionine gamma-lyase | Homo sapiens (human) | Kd | 3.4000 | 1 | 1 |
| endoribonuclease toxin MazF | Escherichia coli str. K-12 substr. MG1655 | EC50 | 44.3333 | 2 | 3 |
| G-protein coupled receptor 55 | Homo sapiens (human) | EC50 | 0.5000 | 1 | 1 |
| insulin-degrading enzyme isoform 1 | Homo sapiens (human) | EC50 | 54.7295 | 2 | 4 |
| intestinal alkaline phosphatase precursor | Mus musculus (house mouse) | EC50 | 62.1000 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | EC50 | 0.3600 | 2 | 2 |
| POsterior Segregation | Caenorhabditis elegans | EC50 | 186.6810 | 1 | 1 |
| recombinase A | Mycobacterium tuberculosis H37Rv | EC50 | 78.6500 | 2 | 2 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | EC50 | 113.8860 | 1 | 1 |
| Zinc finger protein mex-5 | Caenorhabditis elegans | EC50 | 113.8860 | 1 | 1 |
Other Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Albumin | Bos taurus (cattle) | Kdiss | 2.9000 | 1 | 1 |
| aryl hydrocarbon receptor nuclear translocator | Homo sapiens (human) | AC50 | 0.7340 | 1 | 1 |
| Caspase 6, apoptosis-related cysteine peptidase | Homo sapiens (human) | AC50 | 1.6000 | 1 | 1 |
| CDK5 | Homo sapiens (human) | AC50 | 14.9150 | 1 | 2 |
| Cell death-related nuclease 4 | Caenorhabditis elegans | INH | 100.0000 | 1 | 1 |
| Cyclin-dependent kinase 5, regulatory subunit 1 (p35) | Homo sapiens (human) | AC50 | 14.9150 | 1 | 2 |
| Cystathionine gamma-lyase | Homo sapiens (human) | alphaKi | 4.2000 | 1 | 1 |
| cystic fibrosis transmembrane conductance regulator ATP-binding cassette sub-family C member 7 | Homo sapiens (human) | AC50 | 2.9600 | 1 | 1 |
| Dihydrolipoyl dehydrogenase | Plasmodium falciparum (malaria parasite P. falciparum) | Km | 49.0000 | 1 | 1 |
| Dihydrolipoyl dehydrogenase, mitochondrial | Sus scrofa (pig) | Km | 28.0000 | 1 | 1 |
| DNA repair protein RAD52 homolog isoform a | Homo sapiens (human) | AC50 | 0.9360 | 1 | 1 |
| FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | Mycobacterium tuberculosis H37Rv | AC50 | 2.7300 | 1 | 1 |
| Glucocorticoid receptor | Homo sapiens (human) | Kis | 453.0000 | 1 | 1 |
| Glutathione reductase, mitochondrial | Homo sapiens (human) | Km | 6.3000 | 1 | 1 |
| H3 histone acetyltransferase | Candida albicans SC5314 | AC50 | 6.0800 | 1 | 1 |
| heat shock protein 90, putative | Plasmodium falciparum 3D7 | AC50 | 0.7350 | 1 | 1 |
| heat shock protein HSP 90-alpha isoform 2 | Homo sapiens (human) | AC50 | 0.5700 | 1 | 1 |
| histone-lysine N-methyltransferase NSD2 isoform 1 | Homo sapiens (human) | AC50 | 10.5050 | 1 | 2 |
| HSP40, subfamily A [Plasmodium falciparum 3D7] | Plasmodium falciparum 3D7 | AbsAC1000_uM | 1.0030 | 1 | 1 |
| hypothetical protein CAALFM_CR05890CA | Candida albicans SC5314 | AC50 | 6.0800 | 1 | 1 |
| LANA | Human gammaherpesvirus 8 | AC50 | 5.8193 | 3 | 3 |
| Microtubule-associated protein tau | Homo sapiens (human) | 2nd Test Concentration | 0.7200 | 1 | 1 |
| Nuclear factor NF-kappa-B p105 subunit | Homo sapiens (human) | Concentration | 100.0000 | 1 | 1 |
| protein AF-9 isoform a | Homo sapiens (human) | AC50 | 2.1165 | 1 | 2 |
| replicative DNA helicase | Mycobacterium tuberculosis H37Rv | AC50 | 58.1800 | 2 | 2 |
| Ribonuclease T | Escherichia coli K-12 | INH | 10.0000 | 1 | 1 |
| Solute carrier family 22 member 1 | Homo sapiens (human) | Activity | 7.7000 | 1 | 1 |
| Thioredoxin reductase 1, cytoplasmic | Homo sapiens (human) | Km | 95.0000 | 1 | 1 |
| transforming acidic coiled-coil-containing protein 3 | Homo sapiens (human) | AC50 | 0.7340 | 1 | 1 |