A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act.
| Member | Definition | Class |
|---|
| 6,6-dimethyl-2-methylenebicyclo(3.1.1)heptan-3-ol | A pinane monoterpenoid that is a bicyclo[3.1.1]heptane substituted by two methyl groups at position 6, a methylidene group at position 2 and a hydroxy group at position 3. | pinocarveol |
| alpha-asarone | The trans-isomer of asarone. | alpha-asarone |
| beta-asarone | The cis-isomer of asarone. | beta-asarone |
| brexanolone | A 3-hydroxy-5alpha-pregnan-20-one in which the hydroxy group at position 3 has alpha-configuration. It is a metabolite of the sex hormone progesterone and used for the treatment of postpartum depression in women. | brexanolone |
| chlorazepate | A 1,4-benzodiazepinone in which the oxo group is at position 2, and which is substituted at positions 3, 5, and 7 by carboxy, phenyl and chloro groups, respectively. | clorazepic acid |
| clobazam | 7-Chloro-1H-1,5-benzodiazepine-2,4(3H,5H)-dione in which the hydrogen attached to the nitrogen at position 1 is substituted by a methyl group, whilst that attached to the other nitrogen is substituted by a phenyl group. It is used for the short-term management of acute anxiety and as an adjunct in the treatment of epilepsy in association with other antiepileptics. | clobazam |
| clonazepam | 1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus and associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation. | clonazepam |
| clorazepate dipotassium | The compound of monopotassium clorazepate with potassium hydroxide. It is used for the management of anxiety disorders, for the short-term relief of anxiety, as adjunctive therapy in the management of epilepsy, and for the symptomatic relief of acute alcohol withdrawal. | dipotassium clorazepate |
| estazolam | A triazolo[4,3-a][1,4]benzodiazepine having a phenyl group at position 6 and a chloro substituent at position 8. A short-acting benzodiazepine with general properties similar to diazepam, it is given by mouth as a hypnotic in the short-term management of insomnia. | estazolam |
| isoliquiritigenin | A member of the class of chalcones that is trans-chalcone hydroxylated at C-2', -4 and -4'. | isoliquiritigenin |
| nimetazepam | A nitrazepam which is substituted at positions 1 by a methyl group. It is used as an anticonvulsant and as a hypnotic for the short-term management of insomnia. | nimetazepam |
| nitrazepam | A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one which is substituted at positions 5 and 7 by phenyl and nitro groups, respectively. It is used as a hypnotic for the short-term management of insomnia and for the treatment of epileptic spasms in infants (West's syndrome). | nitrazepam |
| nordazepam | A 1,4-benzodiazepinone having phenyl and chloro substituents at positions 5 and 7 respectively; it has anticonvulsant, anxiolytic, muscle relaxant and sedative properties but is used primarily in the treatment of anxiety. | nordazepam |
| secobarbital | A member of the class of barbiturates that is barbituric acid in which the hydrogens at position 5 are substituted by prop-2-en-1-yl and pentan-2-yl groups. | secobarbital |
| valerenic acid | A monocarboxylic acid that is 2-methylprop-2-enoic acid which is substituted at position 3 by a 3,7-dimethyl-2,4,5,6,7,7a-hexahydro-1H-inden-4-yl group. A bicyclic sesquiterpenoid constituent of the essential oil of the Valerian plant. | valerenic acid |
| verruculogen | An organic heterohexacyclic compound that is a mycotoxic indole alkaloid isolated from Penicillium and Aspergillus species. | verruculogen |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 26.6514 | 1 | 2 |
| 2,3-bisphosphoglycerate-independent phosphoglycerate mutase | Leishmania major strain Friedlin | Potency | 37.9330 | 1 | 1 |
| 67.9K protein | Vaccinia virus | Potency | 16.8037 | 2 | 2 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 17.7828 | 1 | 1 |
| Alpha-synuclein | Homo sapiens (human) | Potency | 32.6427 | 1 | 1 |
| Amyloid-beta precursor protein | Homo sapiens (human) | Potency | 16.3601 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 19.5805 | 7 | 12 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 10.9845 | 4 | 4 |
| Ataxin-2 | Homo sapiens (human) | Potency | 17.8549 | 2 | 2 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 6.0120 | 1 | 1 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 13.3722 | 2 | 2 |
| atrial natriuretic peptide receptor 1 precursor | Homo sapiens (human) | Potency | 30.1313 | 1 | 1 |
| atrial natriuretic peptide receptor 2 precursor | Homo sapiens (human) | Potency | 26.1216 | 1 | 1 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 50.1187 | 2 | 2 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 10.3546 | 1 | 2 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 112.2020 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 7.6110 | 1 | 2 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 62.3032 | 2 | 2 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 3.9811 | 1 | 1 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 7.9433 | 1 | 1 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 43.6486 | 1 | 1 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 6.9906 | 2 | 4 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 13.8029 | 1 | 2 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 4.2765 | 1 | 3 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 85.8943 | 1 | 3 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| endonuclease IV | Escherichia coli | Potency | 0.6310 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 34.5733 | 7 | 8 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 71.1083 | 1 | 1 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 35.4548 | 7 | 10 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 44.2348 | 1 | 3 |
| Fatty-acid amide hydrolase 1 | Rattus norvegicus (Norway rat) | Potency | 19.9526 | 1 | 1 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 8.4368 | 1 | 1 |
| G | Vesicular stomatitis virus | Potency | 43.6486 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 6.9906 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 6.9906 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 6.9906 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 6.9906 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 6.9906 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 6.9906 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 6.9906 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 6.9906 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 6.9906 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 6.9906 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 6.9906 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 6.9906 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 6.9906 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 6.9906 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 6.9906 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 6.9906 | 1 | 2 |
| geminin | Homo sapiens (human) | Potency | 13.0472 | 4 | 6 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 40.1510 | 2 | 2 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 17.6316 | 2 | 2 |
| GLS protein | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 11.2637 | 6 | 9 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 4.4866 | 4 | 7 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 63.3753 | 1 | 1 |
| heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | Homo sapiens (human) | Potency | 23.7996 | 1 | 2 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 58.0918 | 2 | 2 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 7.9433 | 1 | 3 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| histone-lysine N-methyltransferase 2A isoform 2 precursor | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 43.6486 | 1 | 1 |
| IDH1 | Homo sapiens (human) | Potency | 25.9290 | 1 | 1 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 43.6486 | 1 | 2 |
| Interferon beta | Homo sapiens (human) | Potency | 45.8718 | 2 | 4 |
| interleukin 8 | Homo sapiens (human) | Potency | 74.9780 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 8.4168 | 1 | 4 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 10.6910 | 1 | 1 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 9.7121 | 1 | 5 |
| muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 15.8489 | 1 | 1 |
| Nrf2 | Homo sapiens (human) | Potency | 16.5928 | 2 | 2 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 68.9281 | 3 | 3 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 37.5780 | 1 | 1 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 12.5941 | 2 | 6 |
| nuclear receptor subfamily 1, group I, member 2 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 1 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 63.3753 | 1 | 1 |
| P53 | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 21.3313 | 1 | 1 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 15.1014 | 1 | 1 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 56.9772 | 1 | 1 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 31.9143 | 4 | 4 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 3.9811 | 1 | 1 |
| PPM1D protein | Homo sapiens (human) | Potency | 46.6128 | 1 | 2 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 25.1555 | 2 | 4 |
| progesterone receptor | Homo sapiens (human) | Potency | 28.3087 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 30.4108 | 2 | 2 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 47.4618 | 3 | 3 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| serine/threonine-protein kinase mTOR isoform 1 | Homo sapiens (human) | Potency | 26.1216 | 1 | 1 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 41.2140 | 2 | 2 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 41.2140 | 2 | 2 |
| Smad3 | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 19.3429 | 2 | 5 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 34.8728 | 2 | 2 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 32.0194 | 2 | 5 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 39.8107 | 2 | 2 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 62.0506 | 1 | 2 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 14.3120 | 1 | 1 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 49.1648 | 3 | 3 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 66.7820 | 1 | 3 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 63.3753 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 17-beta-hydroxysteroid dehydrogenase type 1 | Homo sapiens (human) | IC50 | 2.8300 | 1 | 1 |
| 17-beta-hydroxysteroid dehydrogenase type 2 | Homo sapiens (human) | IC50 | 0.3600 | 1 | 1 |
| 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Homo sapiens (human) | IC50 | 2.9482 | 2 | 2 |
| 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Schizosaccharomyces pombe 972h- | IC50 | 2,488.0000 | 1 | 1 |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | IC50 | 0.0380 | 1 | 1 |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | Ki | 73.0000 | 1 | 1 |
| 72 kDa type IV collagenase | Homo sapiens (human) | IC50 | 0.0100 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Homo sapiens (human) | IC50 | 0.3200 | 1 | 1 |
| Amine oxidase [flavin-containing] A | Rattus norvegicus (Norway rat) | IC50 | 15.6000 | 2 | 2 |
| Amine oxidase [flavin-containing] B | Rattus norvegicus (Norway rat) | IC50 | 47.2000 | 1 | 1 |
| Amyloid-beta precursor protein | Homo sapiens (human) | IC50 | 19.7000 | 1 | 1 |
| Aromatase | Homo sapiens (human) | IC50 | 3.8000 | 1 | 1 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| Beta-secretase 1 | Homo sapiens (human) | IC50 | 42.2500 | 2 | 2 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 133.6667 | 2 | 3 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| Cholecystokinin receptor type A | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 2 | 2 |
| Collagenase 3 | Homo sapiens (human) | IC50 | 0.0140 | 1 | 1 |
| Cytochrome P450 1A2 | Homo sapiens (human) | IC50 | 0.2690 | 1 | 1 |
| Cytochrome P450 2D6 | Homo sapiens (human) | IC50 | 0.2690 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 0.2690 | 1 | 1 |
| Estrogen receptor | Homo sapiens (human) | IC50 | 1.8700 | 1 | 1 |
| Estrogen receptor beta | Homo sapiens (human) | IC50 | 0.2690 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | IC50 | 0.0501 | 6 | 8 |
| Gamma-aminobutyric acid | Mus musculus (house mouse) | IC50 | 0.0000 | 1 | 1 |
| Gamma-aminobutyric acid | Mus musculus (house mouse) | Ki | 73.0000 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Bos taurus (cattle) | IC50 | 0.0380 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Homo sapiens (human) | IC50 | 190,579.5055 | 2 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Mus musculus (house mouse) | IC50 | 0.0370 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | IC50 | 0.0501 | 6 | 8 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Bos taurus (cattle) | Ki | 0.0008 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Homo sapiens (human) | Ki | 0.0008 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Mus musculus (house mouse) | Ki | 73.0000 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Bos taurus (cattle) | IC50 | 0.0380 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Homo sapiens (human) | IC50 | 190,579.5055 | 2 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Mus musculus (house mouse) | IC50 | 0.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | IC50 | 0.0501 | 6 | 8 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Bos taurus (cattle) | Ki | 0.0008 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Homo sapiens (human) | Ki | 0.0008 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Mus musculus (house mouse) | Ki | 73.0000 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Bos taurus (cattle) | IC50 | 0.0380 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Homo sapiens (human) | IC50 | 190,579.5055 | 2 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Mus musculus (house mouse) | IC50 | 0.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | IC50 | 0.0501 | 6 | 8 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Bos taurus (cattle) | Ki | 0.0008 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Homo sapiens (human) | Ki | 0.0008 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Mus musculus (house mouse) | Ki | 73.0000 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Bos taurus (cattle) | IC50 | 0.0380 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Homo sapiens (human) | IC50 | 190,579.5055 | 2 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Mus musculus (house mouse) | IC50 | 0.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | IC50 | 0.0501 | 6 | 8 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Bos taurus (cattle) | Ki | 0.0008 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Homo sapiens (human) | Ki | 0.0008 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Mus musculus (house mouse) | Ki | 73.0000 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Homo sapiens (human) | IC50 | 190,579.5055 | 2 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Mus musculus (house mouse) | IC50 | 0.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | IC50 | 0.0501 | 6 | 8 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Homo sapiens (human) | Ki | 0.0008 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Mus musculus (house mouse) | Ki | 73.0000 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Homo sapiens (human) | IC50 | 190,579.5055 | 2 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Mus musculus (house mouse) | IC50 | 0.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | IC50 | 0.0501 | 6 | 8 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Homo sapiens (human) | Ki | 0.0008 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Mus musculus (house mouse) | Ki | 73.0000 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Bos taurus (cattle) | IC50 | 0.0380 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Homo sapiens (human) | IC50 | 190,579.5055 | 2 | 4 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Mus musculus (house mouse) | IC50 | 0.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | IC50 | 0.0501 | 6 | 8 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Bos taurus (cattle) | Ki | 0.0008 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Homo sapiens (human) | Ki | 0.0008 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Mus musculus (house mouse) | Ki | 73.0000 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Homo sapiens (human) | IC50 | 190,579.5055 | 2 | 4 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | IC50 | 0.0501 | 6 | 8 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Homo sapiens (human) | Ki | 0.0008 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Homo sapiens (human) | IC50 | 190,579.5055 | 2 | 4 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Mus musculus (house mouse) | IC50 | 0.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | IC50 | 0.0501 | 6 | 8 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Homo sapiens (human) | Ki | 0.0008 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Mus musculus (house mouse) | Ki | 73.0000 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit delta | Homo sapiens (human) | IC50 | 190,579.5055 | 2 | 4 |
| Gamma-aminobutyric acid receptor subunit delta | Mus musculus (house mouse) | IC50 | 0.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | IC50 | 0.0501 | 6 | 8 |
| Gamma-aminobutyric acid receptor subunit delta | Homo sapiens (human) | Ki | 0.0008 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit delta | Mus musculus (house mouse) | Ki | 73.0000 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit epsilon | Homo sapiens (human) | IC50 | 190,579.5055 | 2 | 4 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | IC50 | 0.0501 | 6 | 8 |
| Gamma-aminobutyric acid receptor subunit epsilon | Homo sapiens (human) | Ki | 0.0008 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Homo sapiens (human) | IC50 | 190,579.5055 | 2 | 4 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Mus musculus (house mouse) | IC50 | 0.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | IC50 | 0.0501 | 6 | 8 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Homo sapiens (human) | Ki | 0.0008 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Mus musculus (house mouse) | Ki | 73.0000 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Bos taurus (cattle) | IC50 | 0.0380 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Homo sapiens (human) | IC50 | 190,579.5055 | 2 | 4 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Mus musculus (house mouse) | IC50 | 0.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | IC50 | 0.0501 | 6 | 8 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Bos taurus (cattle) | Ki | 0.0008 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Homo sapiens (human) | Ki | 0.0008 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Mus musculus (house mouse) | Ki | 73.0000 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Homo sapiens (human) | IC50 | 190,579.5055 | 2 | 4 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Mus musculus (house mouse) | IC50 | 0.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | IC50 | 0.0501 | 6 | 8 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Homo sapiens (human) | Ki | 0.0008 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Mus musculus (house mouse) | Ki | 73.0000 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit pi | Homo sapiens (human) | IC50 | 190,579.5055 | 2 | 4 |
| Gamma-aminobutyric acid receptor subunit pi | Mus musculus (house mouse) | IC50 | 0.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | IC50 | 0.0501 | 6 | 8 |
| Gamma-aminobutyric acid receptor subunit pi | Homo sapiens (human) | Ki | 0.0008 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit pi | Mus musculus (house mouse) | Ki | 73.0000 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit theta | Homo sapiens (human) | IC50 | 190,579.5055 | 2 | 4 |
| Gamma-aminobutyric acid receptor subunit theta | Mus musculus (house mouse) | IC50 | 0.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit theta | Homo sapiens (human) | Ki | 0.0008 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit theta | Mus musculus (house mouse) | Ki | 73.0000 | 1 | 3 |
| Gastrin/cholecystokinin type B receptor | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| Glucose-6-phosphate 1-dehydrogenase | Homo sapiens (human) | IC50 | 66.0000 | 1 | 1 |
| Integrase | Human immunodeficiency virus 1 | IC50 | 100.0000 | 2 | 2 |
| Interstitial collagenase | Homo sapiens (human) | IC50 | 0.0160 | 1 | 1 |
| Lysine-specific demethylase 4C | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| Lysine-specific demethylase 4C | Homo sapiens (human) | Ki | 200.0000 | 1 | 1 |
| Matrilysin | Homo sapiens (human) | IC50 | 0.0080 | 1 | 1 |
| Matrix metalloproteinase-9 | Homo sapiens (human) | IC50 | 1.3265 | 2 | 2 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| NACHT, LRR and PYD domains-containing protein 3 | Homo sapiens (human) | IC50 | 5.8200 | 2 | 2 |
| Neuronal acetylcholine receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Ki | 0.0008 | 1 | 1 |
| Neuronal acetylcholine receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Ki | 0.0008 | 1 | 1 |
| Nuclear factor NF-kappa-B p100 subunit | Homo sapiens (human) | IC50 | 32.0000 | 1 | 1 |
| Nuclear factor NF-kappa-B p105 subunit | Homo sapiens (human) | IC50 | 32.0000 | 1 | 1 |
| Polyunsaturated fatty acid 5-lipoxygenase | Rattus norvegicus (Norway rat) | IC50 | 35.0000 | 1 | 1 |
| Proteasome subunit beta type-5 | Homo sapiens (human) | IC50 | 4.8800 | 1 | 1 |
| Protein disulfide-isomerase | Homo sapiens (human) | Ki | 36.1000 | 1 | 1 |
| Sodium- and chloride-dependent betaine transporter | Rattus norvegicus (Norway rat) | IC50 | 0.0910 | 1 | 1 |
| Sodium- and chloride-dependent GABA transporter 1 | Rattus norvegicus (Norway rat) | IC50 | 0.0910 | 1 | 1 |
| Sodium- and chloride-dependent GABA transporter 2 | Rattus norvegicus (Norway rat) | IC50 | 0.0910 | 1 | 1 |
| Sodium- and chloride-dependent GABA transporter 3 | Rattus norvegicus (Norway rat) | IC50 | 0.0910 | 1 | 1 |
| Stromelysin-1 | Homo sapiens (human) | IC50 | 0.0810 | 1 | 1 |
| Transcription factor p65 | Homo sapiens (human) | IC50 | 32.0000 | 1 | 1 |
| Translocator protein | Homo sapiens (human) | IC50 | 254,106.0000 | 1 | 3 |
| Translocator protein | Bos taurus (cattle) | Ki | 0.0008 | 1 | 1 |
| Tyrosine-protein phosphatase non-receptor type 1 | Homo sapiens (human) | IC50 | 55.0000 | 2 | 2 |
| Tyrosyl-DNA phosphodiesterase 1 | Homo sapiens (human) | IC50 | 55.0000 | 1 | 1 |
| Xanthine dehydrogenase/oxidase | Bos taurus (cattle) | IC50 | 47.3000 | 1 | 1 |