Any protective agent that is able to prevent damage to the heart.
| Member | Definition | Class |
|---|
| (E)-2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucoside | A stilbenoid that is trans-stilbene which has been substituted by hydroxy groups at positions 2, 3, 5, and 4', and in which the hydroxy group at positon 2 has then been converted to the corresponding the beta-D-glucoside. | (E)-2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucoside |
| 3-(2,2,2-trimethylhydrazine)propionate | An ammonium betaine that is beta-alaninate in which one of the amino hydrogens is replaced by a trimethylamino group. A clinically used cardioprotective drug that is used for treatment of heart failure, myocardial infarction, arrhythmia, atherosclerosis and diabetes. | meldonium |
| 5-methoxytryptamine | A member of the class of tryptamines that is the methyl ether derivative of serotonin. | 5-methoxytryptamine |
| angiotensin i | A nine amino acid peptide which is formed when angiotensin converting enzyme 2 (ACE2) hydrolyzes the carboxy terminal leucine from angiotensin I. It is a anti-cardiac hypertrophy agent. | angiotensin (1-9) dizwitterion; angiotensin (1-9) |
| angiotensin i | A peptide zwitterion that is the dizwitterionic form of angiotensin (1-9) having both carboxy groups deprotonated and the aspartyl amino group and arginine side-chain protonated. It is the major species at pH 7.3. | angiotensin (1-9) dizwitterion; angiotensin (1-9) |
| baicalin | The glycosyloxyflavone which is the 7-O-glucuronide of baicalein. It is an active ingredient of Chinese herbal medicine Scutellaria baicalensis. | baicalin |
| bay 60-6583 | A member of the class of cyanopyridines that is 6-amino-3,5-dicyano-4-(4-hydroxyphenyl)-2-sulfanylpyridine in which the hydroxy and sulfanyl hydrogens are replaced by cyclopropylmethyl and carboxamidomethyl groups respectively. | BAY 60-6583 |
| dilazep | A member of the class of diazepanes that is 1,4-diazepane substituted by 3-[(3,4,5-trimethoxybenzoyl)oxy]propyl groups at positions 1 and 4. It is a potent adenosine uptake inhibitor that exhibits antiplatelet, antianginal and vasodilator properties. | dilazep |
| diosmetin | A monomethoxyflavone that is the 4'-methyl ether derivative of luteolin. It is a natural product isolated from citrus fruits which exhibits a range of pharmacological activities. | diosmetin |
| ferulic acid | A ferulic acid consisting of trans-cinnamic acid bearing methoxy and hydroxy substituents at positions 3 and 4 respectively on the phenyl ring. | ferulic acid |
| ginsenoside rb3 | A ginsenoside found in Panax species that is dammarane which is substituted by hydroxy groups at the 3beta, 12beta and 20 pro-S positions, in which the hydroxy groups at positions 3 and 20 have been converted to the corresponding beta-D-glucopyranosyl-(1->2)-beta-D-glucopyranoside and beta-D-xylopyranosyl-(1->6)-beta-D-glucopyranoside respectively, and in which a double bond has been introduced at the 24-25 position. | ginsenoside Rb3 |
| ginsenoside rg2 | A ginsenoside found in Panax species that is dammarane which is substituted by hydroxy groups at the 3beta, 6alpha, 12beta and 20 pro-S positions, in which the hydroxy group at position 6 has been converted to the corresponding alpha-L-rhamnopyranosyl-(1->2)-beta-D-glucopyranoside, and in which a double bond has been introduced at the 24-25 position. | ginsenoside Rg2 |
| ginsenoside rh2 | A ginsenoside found in Panax species that is dammarane which is substituted by hydroxy groups at the 3beta, 12beta and 20 pro-S positions, in which the hydroxy group at position 3 has been converted to the corresponding beta-D-glucopyranoside, and in which a double bond has been introduced at the 24-25 position. | (20S)-ginsenoside Rh2 |
| jq1 compound | A member of the class of thienotriazolodiazepines that is the tert-butyl ester of [(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetic acid. An inhibitor of bromodomain-containing protein 4 that exhibits anti-cancer and cardioprotective properties. | JQ1 |
| jte 607 | The dihydrochloride salt of JTE-607. It is a cytokine inhibitor which suppresses the production of proinflammatory cytokines such as interleukin (IL-1beta), IL-6, IL-8, granulocyte macrophage colony stimulating factor (GM-CSF), and tumor necrosis factor (TNF-alpha). It acts as a pro-drug which is cleaved by carboxylesterase 1 (CES1) to its active free acid form, which then binds to cleavage and polyadenylation specificity factor 3 (CPSF3). | JTE-607 dihydrochloride |
| lasofoxifene | A member of the class of tetralins that is 5,6,7,8-tetrahydronaphthalen-2-ol in which the hydrogens at positions 5 and 6 are replaced by 4-[2-(pyrrolidin-1-yl)ethoxy]phenyl and phenyl groups, respectively (the 5R,6S-stereoisomer). It is a selective estrogen receptor modulator indicated for the prevention and treatment of osteoporosis in post-menopausal women. | lasofoxifene |
| liproxstatin-1 | An azaspiro compound that is 1'H-spiro[piperidine-4,2'-quinoxaline] in which the hydrogen at position 3' is replaced by a (3-chlorobenzyl)amino group. It is a potent inhibitor of ferroptosis. | liproxstatin-1 |
| methylene blue | An organic chloride salt having 3,7-bis(dimethylamino)phenothiazin-5-ium as the counterion. A commonly used dye that also exhibits antioxidant, antimalarial, antidepressant and cardioprotective properties. | methylene blue |
| mocetinostat | A benzamide obtained by formal condensation of the carboxy group of 4-({[4-(pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzoic acid with one of the amino groups of benzene-1,2-diamine. It is an orally active and isotype-selective HDAC inhibitor which exhibits antitumour activity (IC50 = 0.15, 0.29, 1.66 and 0.59 muM for HDAC1, HDAC2, HDAC3 and HDAC11). | mocetinostat |
| molsidomine | A member of the class of oxadiazoles that is 1,2,3-oxadiazole substituted by morpholin-4-yl and (ethoxycarbonyl)azanidyl groups at positions 3 and 5, respectively. It is used as a vasodilator drug for the treatment of myocardial ischemic syndrome and congestive heart failure. | 1-ethoxy-N-[3-(4-morpholinyl)-5-oxadiazol-3-iumyl]methanimidate; molsidomine |
| molsidomine | A member of the class of oxadiazoles that is 1,2,3-oxadiazole substituted by morpholin-4-yl and (ethoxycarbonyl)azanidyl groups at positions 3 and 5, respectively. It is used as a vasodilator drug for the treatment of myocardial ischemic syndrome and congestive heart failure. | 1-ethoxy-N-[3-(4-morpholinyl)-5-oxadiazol-3-iumyl]methanimidate; molsidomine |
| mor-14 | A hydroxypiperidine that is duvoglustat in which the amino hydrogen is replaced by a methyl group. It is an inhibitor of alpha-glucosidase, an agonist of the glucose sensor SGLT3 and exhibits anti-HIV activity. | N-methyl-1-deoxynojirimycin |
| nsc 664704 | An indolobenzazepine that is paullone in which the hydrogen at position 9 is replaced by a bromo substituent. It is an ATP-competitive inhibitor of cyclin-dependent kinases (CDKs) and glycogen synthase kinase 3beta (GSK3beta). | kenpaullone |
| pioglitazone | A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity. | pioglitazone |
| pj-34 | A member of the class of phenanthridines that is 5,6-dihydrophenanthridine substituted at positions 2 and 6 by (N,N-dimethylglycyl)amino and oxo groups, respectively. It is a potent inhibitor of poly(ADP-ribose) polymerases PARP1 and PARP2 (IC50 of 110 nM and 86 nM, respectively) and exhibits anti-cancer, cardioprotective and neuroprotective properties. | PJ34 |
| ramipril | A dipeptide that is the prodrug for ramiprilat, the active metabolite obtained by hydrolysis of the ethyl ester group. An angiotensin-converting enzyme (ACE) inhibitor, used to treat high blood pressure and congestive heart failure. | ramipril |
| ramiprilat | A dipeptide that is the active metabolite of ramipril. An angiotensin-converting enzyme (ACE) inhibitor, used to treat high blood pressure and congestive heart failure. | ramiprilat |
| rosuvastatin | A dihydroxy monocarboxylic acid that is (6E)-7-{4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-(propan-2-yl)pyrimidin-5-yl} hept-6-enoic acid carrying two hydroxy substituents at positions 3 and 5 (the 3R,5S-diastereomer). | rosuvastatin |
| rosuvastatin calcium | An organic calcium salt that is the hemicalcium salt of rosuvastatin. | rosuvastatin calcium |
| salvianolic acid B | A member of the class of 1-benzofurans that is an antioxidant and free radical scavenging compound extracted from S. miltiorrhiza | salvianolic acid B |
| thymoquinone | A member of the class of 1,4-benzoquinones that is 1,4-bezoquinone in which the hydrogens at positions 2 and 5 are replaced by methyl and isopropyl groups, respectively. It is a natural compound isolated from Nigella sativa which has demonstrated promising chemotherapeutic activity. | thymoquinone |
| ursodoxicoltaurine | A bile acid taurine conjugate derived from ursoodeoxycholic acid. | tauroursodeoxycholic acid |
| zofenopril | A proline derivative that is 4-(phenylsulfanyl)-L-proline in which the amine proton is replaced by a (2S)-3-(benzoylsulfanyl)-2-methylpropanoyl group. A prodrug for zofenoprilat. | zofenopril |
| zofenoprilate | A proline derivative that is 4-(phenylsulfanyl)-L-proline in which the amine proton is replaced by a (2S)-2-methyl-3-sulfanylpropanoyl group. The active metabolite of zofenopril. | zofenoprilat |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 67.9K protein | Vaccinia virus | Potency | 12.4664 | 2 | 3 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 3.3766 | 4 | 8 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 0.4364 | 1 | 1 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 22.0164 | 1 | 2 |
| Alpha-synuclein | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 7.0597 | 7 | 14 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 4.9957 | 2 | 4 |
| arylsulfatase A | Homo sapiens (human) | Potency | 21.3313 | 1 | 1 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 10.0741 | 3 | 3 |
| Ataxin-2 | Homo sapiens (human) | Potency | 21.0612 | 2 | 3 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 18.9718 | 2 | 2 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 11.0604 | 2 | 3 |
| atrial natriuretic peptide receptor 1 precursor | Homo sapiens (human) | Potency | 37.9330 | 1 | 1 |
| atrial natriuretic peptide receptor 2 precursor | Homo sapiens (human) | Potency | 14.6892 | 1 | 1 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 28.8185 | 2 | 5 |
| BRCA1 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 55.3026 | 1 | 2 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 10.8707 | 1 | 1 |
| caspase-3 | Homo sapiens (human) | Potency | 10.8707 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 11.9895 | 2 | 3 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 19.7830 | 2 | 2 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 31.0378 | 1 | 3 |
| Chain A, ATP-DEPENDENT DNA HELICASE Q1 | Homo sapiens (human) | Potency | 23.7358 | 2 | 2 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 28.5991 | 2 | 2 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 39.8107 | 1 | 2 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 28.3708 | 2 | 2 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 47.3936 | 1 | 2 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 12.4961 | 1 | 3 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 22.3342 | 1 | 1 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 28.0500 | 2 | 3 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| chaperonin-containing TCP-1 beta subunit homolog | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 78.1171 | 2 | 2 |
| ClpP | Bacillus subtilis | Potency | 19.9526 | 1 | 1 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 11.8961 | 1 | 2 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 10.0000 | 1 | 3 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 6.3837 | 1 | 5 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 10.9006 | 1 | 3 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 0.3981 | 1 | 1 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 8.9206 | 2 | 9 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 7.9934 | 1 | 5 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 6.8206 | 1 | 3 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 3.2641 | 1 | 1 |
| DNA dC->dU-editing enzyme APOBEC-3F isoform a | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| DNA dC->dU-editing enzyme APOBEC-3G isoform 1 | Homo sapiens (human) | Potency | 23.7150 | 1 | 1 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| DNA polymerase eta isoform 1 | Homo sapiens (human) | Potency | 56.2341 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 51.6252 | 1 | 2 |
| dopamine D1 receptor | Homo sapiens (human) | Potency | 18.3564 | 1 | 1 |
| endonuclease IV | Escherichia coli | Potency | 8.1548 | 1 | 2 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 25.3422 | 8 | 23 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 11.8832 | 1 | 1 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 1.8580 | 10 | 17 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 50.0427 | 1 | 3 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 4.8719 | 4 | 14 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 12.3221 | 2 | 3 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 10.1493 | 1 | 3 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 27.5020 | 1 | 2 |
| G | Vesicular stomatitis virus | Potency | 6.3837 | 1 | 5 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 9.2875 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 9.2875 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 9.2875 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 9.2875 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 9.2875 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 9.2875 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 9.2875 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 9.2875 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 9.2875 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 9.2875 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 9.2875 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 9.2875 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 9.2875 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 9.2875 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 9.2875 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 9.2875 | 1 | 5 |
| geminin | Homo sapiens (human) | Potency | 8.4966 | 4 | 7 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 8.1765 | 3 | 8 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 6.3096 | 1 | 1 |
| GLS protein | Homo sapiens (human) | Potency | 20.3632 | 2 | 3 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 9.9146 | 2 | 3 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 23.4962 | 1 | 3 |
| Glycoprotein hormones alpha chain | Homo sapiens (human) | Potency | 0.5012 | 1 | 1 |
| Guanine nucleotide-binding protein G | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | Homo sapiens (human) | Potency | 0.0521 | 1 | 1 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 58.2929 | 2 | 2 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 12.3260 | 2 | 13 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 2 |
| histone deacetylase 9 isoform 3 | Homo sapiens (human) | Potency | 12.3066 | 2 | 4 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 11.5301 | 2 | 4 |
| histone-lysine N-methyltransferase 2A isoform 2 precursor | Homo sapiens (human) | Potency | 32.3105 | 1 | 2 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 6.3837 | 1 | 5 |
| huntingtin isoform 2 | Homo sapiens (human) | Potency | 4.5943 | 3 | 4 |
| hypothetical protein, conserved | Trypanosoma brucei | Potency | 19.9526 | 1 | 1 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 42.2707 | 2 | 3 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 2.4865 | 2 | 6 |
| IDH1 | Homo sapiens (human) | Potency | 16.9939 | 1 | 3 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 6.3837 | 1 | 10 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 16.8090 | 1 | 2 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| Interferon beta | Homo sapiens (human) | Potency | 10.9977 | 3 | 19 |
| isocitrate dehydrogenase 1, partial | Homo sapiens (human) | Potency | 52.1194 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 4.6428 | 1 | 3 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 17.0830 | 3 | 4 |
| luciferase | Photuris pensylvanica (Pennsylania firefly) | Potency | 10.0000 | 1 | 1 |
| luteinizing hormone receptor | Homo sapiens (human) | Potency | 84.9214 | 1 | 1 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 10.4111 | 2 | 3 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 19.3512 | 2 | 2 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 7.5114 | 1 | 2 |
| muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 2.8184 | 1 | 1 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 7.3749 | 3 | 4 |
| NFKB1 protein, partial | Homo sapiens (human) | Potency | 3.5036 | 2 | 4 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 0.3162 | 1 | 1 |
| NPC intracellular cholesterol transporter 1 precursor | Homo sapiens (human) | Potency | 0.5174 | 1 | 1 |
| Nrf2 | Homo sapiens (human) | Potency | 18.3564 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 5.5315 | 2 | 6 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 6.2510 | 1 | 2 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 54.9410 | 1 | 1 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 25.1189 | 1 | 1 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 4.1558 | 3 | 7 |
| Ornithine decarboxylase | Rattus norvegicus (Norway rat) | Potency | 3.1623 | 1 | 1 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 12.5925 | 1 | 3 |
| Parkin | Homo sapiens (human) | Potency | 4.1988 | 2 | 2 |
| peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 55.4170 | 2 | 3 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 19.3152 | 2 | 2 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 0.1346 | 1 | 1 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 43.6412 | 1 | 1 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 36.7195 | 1 | 1 |
| phosphoglycerate kinase | Trypanosoma brucei brucei TREU927 | Potency | 17.7828 | 1 | 1 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 79.0420 | 3 | 3 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 5.0910 | 1 | 2 |
| polyprotein | Zika virus | Potency | 27.5020 | 1 | 2 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 17.5594 | 1 | 2 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| PPM1D protein | Homo sapiens (human) | Potency | 9.5058 | 1 | 8 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 11.2076 | 2 | 3 |
| progesterone receptor | Homo sapiens (human) | Potency | 51.0406 | 1 | 2 |
| pyruvate kinase | Leishmania mexicana mexicana | Potency | 6.3096 | 2 | 2 |
| pyruvate kinase PKM isoform a | Homo sapiens (human) | Potency | 39.8107 | 2 | 2 |
| pyruvate kinase PKM isoform b | Homo sapiens (human) | Potency | 3.1623 | 2 | 2 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 8.9623 | 2 | 5 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 0.3663 | 1 | 1 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 16.1295 | 1 | 2 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 20.6032 | 3 | 12 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 27.0627 | 2 | 4 |
| serine-protein kinase ATM isoform a | Homo sapiens (human) | Potency | 13.0258 | 4 | 4 |
| serine/threonine-protein kinase mTOR isoform 1 | Homo sapiens (human) | Potency | 16.5111 | 3 | 3 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 6.7400 | 1 | 1 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 6.7400 | 1 | 1 |
| Smad3 | Homo sapiens (human) | Potency | 3.8932 | 3 | 5 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 25.5154 | 1 | 2 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 10.5385 | 1 | 5 |
| T cell receptor, partial | Homo sapiens (human) | Potency | 6.2841 | 1 | 1 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 17.5019 | 2 | 15 |
| thioredoxin glutathione reductase | Schistosoma mansoni | Potency | 31.6228 | 1 | 1 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 27.7794 | 3 | 5 |
| Thrombopoietin | Homo sapiens (human) | Potency | 0.1585 | 2 | 2 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 16.8542 | 2 | 6 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 40.9811 | 2 | 4 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 19.6430 | 7 | 14 |
| TSHR protein | Homo sapiens (human) | Potency | 15.5035 | 2 | 2 |
| tyrosine-protein kinase Yes | Homo sapiens (human) | Potency | 1.7291 | 1 | 1 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 5.0910 | 1 | 2 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 5.0910 | 1 | 2 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 8.1966 | 2 | 4 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 23.9145 | 1 | 1 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 23.4962 | 1 | 3 |
| Vpr | Human immunodeficiency virus 1 | Potency | 39.8107 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Homo sapiens (human) | IC50 | 0.0045 | 3 | 3 |
| 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Homo sapiens (human) | Ki | 35.5004 | 2 | 2 |
| 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Rattus norvegicus (Norway rat) | IC50 | 1.1315 | 8 | 8 |
| 5-hydroxytryptamine receptor 1A | Homo sapiens (human) | Ki | 0.0032 | 1 | 1 |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | Ki | 0.0048 | 5 | 5 |
| 5-hydroxytryptamine receptor 1B | Homo sapiens (human) | Ki | 0.0035 | 1 | 1 |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | Ki | 0.2015 | 3 | 4 |
| 5-hydroxytryptamine receptor 1D | Homo sapiens (human) | Ki | 0.0054 | 1 | 1 |
| 5-hydroxytryptamine receptor 1D | Rattus norvegicus (Norway rat) | Ki | 0.0020 | 1 | 1 |
| 5-hydroxytryptamine receptor 1F | Rattus norvegicus (Norway rat) | Ki | 0.0020 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | IC50 | 15.0000 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | Ki | 0.1524 | 2 | 2 |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | Ki | 0.5571 | 7 | 7 |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | Ki | 0.5571 | 7 | 7 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | Ki | 0.0450 | 1 | 1 |
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | Ki | 0.5500 | 8 | 8 |
| 5-hydroxytryptamine receptor 4 | Homo sapiens (human) | Ki | 0.1362 | 2 | 2 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | Ki | 0.0690 | 2 | 2 |
| 5-hydroxytryptamine receptor 7 | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| 5-hydroxytryptamine receptor 7 | Homo sapiens (human) | Ki | 0.0035 | 2 | 2 |
| 5-hydroxytryptamine receptor 7 | Rattus norvegicus (Norway rat) | Ki | 0.0009 | 1 | 1 |
| Acetylcholinesterase | Electrophorus electricus (electric eel) | IC50 | 100.0000 | 3 | 3 |
| Acetylcholinesterase | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Adenosine receptor A1 | Rattus norvegicus (Norway rat) | Ki | 9.9033 | 3 | 3 |
| Adenosine receptor A2a | Rattus norvegicus (Norway rat) | Ki | 8.4200 | 2 | 2 |
| Aldo-keto reductase family 1 member B1 | Homo sapiens (human) | IC50 | 147.3000 | 1 | 1 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.2820 | 2 | 2 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.2820 | 2 | 2 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.2820 | 2 | 2 |
| Alpha-glucosidase MAL12 | Saccharomyces cerevisiae S288C | IC50 | 251.4000 | 1 | 1 |
| Alpha-mannosidase 2 | Rattus norvegicus (Norway rat) | Ki | 50.0000 | 1 | 1 |
| Alpha-synuclein | Homo sapiens (human) | IC50 | 0.7500 | 1 | 1 |
| Amine oxidase [flavin-containing] A | Homo sapiens (human) | IC50 | 17.5695 | 2 | 2 |
| Amine oxidase [flavin-containing] A | Rattus norvegicus (Norway rat) | Ki | 0.2708 | 1 | 1 |
| Amine oxidase [flavin-containing] B | Homo sapiens (human) | IC50 | 0.2980 | 2 | 2 |
| Amine oxidase [flavin-containing] B | Homo sapiens (human) | Ki | 0.3234 | 3 | 3 |
| Amine oxidase [flavin-containing] B | Rattus norvegicus (Norway rat) | Ki | 0.8567 | 3 | 3 |
| Amyloid-beta precursor protein | Homo sapiens (human) | IC50 | 108.9100 | 3 | 3 |
| Angiotensin-converting enzyme | Oryctolagus cuniculus (rabbit) | IC50 | 0.2530 | 2 | 2 |
| Angiotensin-converting enzyme | Rattus norvegicus (Norway rat) | IC50 | 0.0080 | 1 | 1 |
| Angiotensin-converting enzyme | Oryctolagus cuniculus (rabbit) | Ki | 0.0004 | 1 | 1 |
| Angiotensin-converting enzyme | Homo sapiens (human) | IC50 | 0.0022 | 1 | 2 |
| Apoptotic peptidase activating factor 1 | Homo sapiens (human) | IC50 | 57.7500 | 2 | 2 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 114.3250 | 1 | 4 |
| Aurora kinase B | Homo sapiens (human) | IC50 | 8.0250 | 1 | 2 |
| Beta-carbonic anhydrase 1 | Mycobacterium tuberculosis H37Rv | Ki | 3.6633 | 1 | 3 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 44.5580 | 6 | 9 |
| Bile salt export pump | Rattus norvegicus (Norway rat) | IC50 | 2.0000 | 1 | 1 |
| Bromodomain testis-specific protein | Homo sapiens (human) | IC50 | 0.1902 | 13 | 13 |
| Bromodomain-containing protein 1 | Homo sapiens (human) | IC50 | 44.5000 | 1 | 1 |
| Bromodomain-containing protein 2 | Homo sapiens (human) | IC50 | 0.0959 | 22 | 22 |
| Bromodomain-containing protein 2 | Homo sapiens (human) | Ki | 0.0128 | 4 | 4 |
| Bromodomain-containing protein 3 | Homo sapiens (human) | IC50 | 0.0573 | 18 | 18 |
| Bromodomain-containing protein 3 | Homo sapiens (human) | Ki | 0.0078 | 4 | 4 |
| Bromodomain-containing protein 4 | Homo sapiens (human) | IC50 | 0.8257 | 119 | 119 |
| Bromodomain-containing protein 4 | Homo sapiens (human) | Ki | 0.0193 | 8 | 8 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 112.2500 | 2 | 4 |
| Canalicular multispecific organic anion transporter 1 | Rattus norvegicus (Norway rat) | Ki | 7.9500 | 1 | 1 |
| Carbonic anhydrase 1 | Homo sapiens (human) | Ki | 206.9633 | 2 | 3 |
| Carbonic anhydrase 12 | Homo sapiens (human) | Ki | 9.7800 | 2 | 2 |
| Carbonic anhydrase 13 | Mus musculus (house mouse) | Ki | 12.2000 | 2 | 2 |
| Carbonic anhydrase 14 | Homo sapiens (human) | Ki | 9.4300 | 2 | 2 |
| Carbonic anhydrase 2 | Homo sapiens (human) | IC50 | 3.2770 | 2 | 2 |
| Carbonic anhydrase 2 | Homo sapiens (human) | Ki | 206.8000 | 2 | 3 |
| Carbonic anhydrase 2 | Mycobacterium tuberculosis H37Rv | Ki | 3.6633 | 1 | 3 |
| Carbonic anhydrase 3 | Homo sapiens (human) | Ki | 11.1000 | 1 | 1 |
| Carbonic anhydrase 4 | Homo sapiens (human) | Ki | 10.8000 | 1 | 1 |
| Carbonic anhydrase 5A, mitochondrial | Homo sapiens (human) | IC50 | 8.8600 | 1 | 1 |
| Carbonic anhydrase 5A, mitochondrial | Homo sapiens (human) | Ki | 7.0400 | 1 | 1 |
| Carbonic anhydrase 5B, mitochondrial | Homo sapiens (human) | Ki | 10.5000 | 1 | 1 |
| Carbonic anhydrase 6 | Homo sapiens (human) | Ki | 8.4500 | 1 | 1 |
| Carbonic anhydrase 7 | Homo sapiens (human) | Ki | 7.4100 | 1 | 1 |
| Carbonic anhydrase 9 | Homo sapiens (human) | IC50 | 9.3900 | 1 | 1 |
| Carbonic anhydrase 9 | Homo sapiens (human) | Ki | 9.8700 | 1 | 1 |
| Carnitine O-palmitoyltransferase 1, liver isoform | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Carnitine O-palmitoyltransferase 2, mitochondrial | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Carnitine O-palmitoyltransferase 2, mitochondrial | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| Casein kinase I isoform alpha | Sus scrofa (pig) | IC50 | 10.0000 | 1 | 1 |
| Casein kinase II subunit alpha | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| Caspase-1 | Homo sapiens (human) | IC50 | 1.0800 | 1 | 1 |
| caspase-3 isoform a preproprotein | Homo sapiens (human) | IC50 | 17.0000 | 1 | 1 |
| caspase-9 isoform alpha precursor | Homo sapiens (human) | IC50 | 17.0000 | 1 | 1 |
| CDGSH iron-sulfur domain-containing protein 1 | Homo sapiens (human) | IC50 | 8.6500 | 1 | 1 |
| CDGSH iron-sulfur domain-containing protein 1 | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 1 |
| CDGSH iron-sulfur domain-containing protein 1 | Homo sapiens (human) | Ki | 0.3700 | 1 | 1 |
| CDGSH iron-sulfur domain-containing protein 2 | Homo sapiens (human) | IC50 | 4.8000 | 1 | 1 |
| Chain A, Cytosol aminopeptidase | Bos taurus (cattle) | Ki | 0.8000 | 1 | 1 |
| Chain A, Exotoxin A | Pseudomonas aeruginosa | Ki | 0.1400 | 1 | 1 |
| Chain E, Fibrin beta chain | Homo sapiens (human) | IC50 | 46.2655 | 2 | 2 |
| Cholecystokinin receptor type A | Homo sapiens (human) | Ki | 0.3020 | 1 | 1 |
| Cholinesterase | Equus caballus (horse) | IC50 | 100.0000 | 1 | 1 |
| Cholinesterase | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| CREB-binding protein | Homo sapiens (human) | IC50 | 9.7153 | 3 | 3 |
| Cruzipain | Trypanosoma cruzi | IC50 | 70.0000 | 2 | 2 |
| Cyclin-A1 | Homo sapiens (human) | IC50 | 0.7300 | 2 | 2 |
| Cyclin-A2 | Homo sapiens (human) | IC50 | 0.7300 | 2 | 2 |
| Cyclin-dependent kinase 1 | Homo sapiens (human) | IC50 | 1.6691 | 11 | 11 |
| Cyclin-dependent kinase 1 | Oryzias latipes (Japanese medaka) | IC50 | 0.4243 | 2 | 6 |
| Cyclin-dependent kinase 2 | Homo sapiens (human) | IC50 | 0.7300 | 2 | 2 |
| Cyclin-dependent kinase 5 activator 1 | Homo sapiens (human) | IC50 | 0.6314 | 7 | 11 |
| Cyclin-dependent kinase 9 | Homo sapiens (human) | IC50 | 0.0640 | 1 | 1 |
| Cyclin-dependent-like kinase 5 | Homo sapiens (human) | IC50 | 0.6314 | 7 | 11 |
| Cyclin-T1 | Homo sapiens (human) | IC50 | 0.0640 | 1 | 1 |
| Cytochrome P450 1A1 | Homo sapiens (human) | IC50 | 0.1400 | 1 | 1 |
| Cytochrome P450 1A1 | Homo sapiens (human) | Ki | 0.0890 | 1 | 1 |
| Cytochrome P450 1A2 | Homo sapiens (human) | IC50 | 1.6285 | 2 | 2 |
| Cytochrome P450 1B1 | Homo sapiens (human) | IC50 | 0.0290 | 1 | 1 |
| Cytochrome P450 1B1 | Homo sapiens (human) | Ki | 0.0160 | 2 | 2 |
| Cytochrome P450 2C19 | Homo sapiens (human) | IC50 | 0.1020 | 1 | 1 |
| Cytochrome P450 2D6 | Homo sapiens (human) | IC50 | 0.1020 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 0.2252 | 3 | 3 |
| D(2) dopamine receptor | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 1 | 1 |
| Delta-type opioid receptor | Mus musculus (house mouse) | IC50 | 14.7200 | 1 | 1 |
| Dihydrolipoyl dehydrogenase | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 1,000.0000 | 1 | 1 |
| Dihydrolipoyl dehydrogenase, mitochondrial | Sus scrofa (pig) | IC50 | 1,000.0000 | 1 | 1 |
| Dihydroorotate dehydrogenase | Leishmania major | IC50 | 405.7535 | 1 | 2 |
| Dipeptidyl peptidase 4 | Homo sapiens (human) | IC50 | 225.0000 | 1 | 1 |
| DNA topoisomerase 1 | Homo sapiens (human) | IC50 | 250.0000 | 1 | 1 |
| DNA topoisomerase 2-alpha | Homo sapiens (human) | IC50 | 250.0000 | 1 | 1 |
| Dual specificity protein kinase CLK1 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Dual specificity tyrosine-phosphorylation-regulated kinase 1A | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 1 | 1 |
| Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 | Homo sapiens (human) | IC50 | 10.3000 | 1 | 1 |
| Enoyl-[acyl-carrier-protein] reductase [NADH] | Francisella tularensis subsp. tularensis SCHU S4 | IC50 | 79.0000 | 1 | 1 |
| Equilibrative nucleoside transporter 1 | Homo sapiens (human) | IC50 | 0.0059 | 3 | 3 |
| Equilibrative nucleoside transporter 2 | Rattus norvegicus (Norway rat) | IC50 | 8.8000 | 1 | 1 |
| Estrogen receptor | Homo sapiens (human) | IC50 | 0.0046 | 8 | 10 |
| Estrogen receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0112 | 1 | 2 |
| Estrogen receptor 1 | Homo sapiens (human) | IC50 | 24.6739 | 1 | 1 |
| Estrogen receptor beta | Homo sapiens (human) | IC50 | 0.0077 | 8 | 10 |
| Estrogen receptor beta | Rattus norvegicus (Norway rat) | IC50 | 0.0112 | 1 | 2 |
| Fatty-acid amide hydrolase 1 | Rattus norvegicus (Norway rat) | Ki | 0.0269 | 1 | 1 |
| G2/mitotic-specific cyclin-B | Marthasterias glacialis (spiny starfish) | IC50 | 0.4243 | 2 | 6 |
| G2/mitotic-specific cyclin-B1 | Homo sapiens (human) | IC50 | 1.7960 | 10 | 10 |
| G2/mitotic-specific cyclin-B2 | Homo sapiens (human) | IC50 | 0.4000 | 6 | 6 |
| G2/mitotic-specific cyclin-B3 | Homo sapiens (human) | IC50 | 0.4000 | 6 | 6 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Ki | 0.0032 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Homo sapiens (human) | Ki | 77.6247 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Ki | 0.0032 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Homo sapiens (human) | Ki | 77.6247 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Ki | 0.0032 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Homo sapiens (human) | Ki | 77.6247 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Ki | 0.0032 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Homo sapiens (human) | Ki | 77.6247 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Ki | 0.0032 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Homo sapiens (human) | Ki | 77.6247 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Ki | 0.0032 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Homo sapiens (human) | Ki | 77.6247 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Ki | 0.0032 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Homo sapiens (human) | Ki | 77.6247 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Ki | 0.0032 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Homo sapiens (human) | Ki | 77.6247 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Ki | 0.0032 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Homo sapiens (human) | Ki | 77.6247 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Ki | 0.0032 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit delta | Homo sapiens (human) | Ki | 77.6247 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Ki | 0.0032 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit epsilon | Homo sapiens (human) | Ki | 77.6247 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Ki | 0.0032 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Homo sapiens (human) | Ki | 77.6247 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Ki | 0.0032 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Homo sapiens (human) | Ki | 77.6247 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Ki | 0.0032 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Homo sapiens (human) | Ki | 77.6247 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Ki | 0.0032 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit pi | Homo sapiens (human) | Ki | 77.6247 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Ki | 0.0032 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit theta | Homo sapiens (human) | Ki | 77.6247 | 1 | 1 |
| Gamma-butyrobetaine dioxygenase | Homo sapiens (human) | IC50 | 62.0000 | 1 | 1 |
| Gamma-butyrobetaine dioxygenase | Homo sapiens (human) | Ki | 16.0000 | 1 | 1 |
| Gastrin/cholecystokinin type B receptor | Homo sapiens (human) | Ki | 0.3020 | 1 | 1 |
| Glutathione reductase | Plasmodium falciparum 3D7 | IC50 | 6.4000 | 1 | 1 |
| Glutathione reductase, mitochondrial | Homo sapiens (human) | IC50 | 16.2000 | 2 | 2 |
| Glycogen synthase kinase 3 | Plasmodium falciparum 3D7 | IC50 | 10.0000 | 1 | 1 |
| Glycogen synthase kinase-3 alpha | Homo sapiens (human) | IC50 | 0.0230 | 1 | 1 |
| Glycogen synthase kinase-3 beta | Homo sapiens (human) | IC50 | 0.0657 | 9 | 9 |
| Glycogen synthase kinase-3 beta | Rattus norvegicus (Norway rat) | IC50 | 0.4243 | 2 | 6 |
| Histone acetyltransferase p300 | Homo sapiens (human) | IC50 | 19.4000 | 1 | 1 |
| Histone deacetylase 1 | Homo sapiens (human) | IC50 | 2.4107 | 18 | 28 |
| Histone deacetylase 1 | Homo sapiens (human) | Ki | 0.0090 | 1 | 1 |
| Histone deacetylase 11 | Homo sapiens (human) | IC50 | 4.6258 | 5 | 14 |
| Histone deacetylase 2 | Homo sapiens (human) | IC50 | 3.3966 | 10 | 19 |
| Histone deacetylase 2 | Homo sapiens (human) | Ki | 0.0324 | 1 | 1 |
| Histone deacetylase 3 | Homo sapiens (human) | IC50 | 3.2758 | 12 | 22 |
| Histone deacetylase 3 | Homo sapiens (human) | Ki | 0.2650 | 1 | 1 |
| Histone deacetylase 4 | Homo sapiens (human) | IC50 | 5.8576 | 6 | 16 |
| Histone deacetylase 5 | Homo sapiens (human) | IC50 | 6.8654 | 6 | 15 |
| Histone deacetylase 6 | Homo sapiens (human) | IC50 | 8.1860 | 10 | 20 |
| Histone deacetylase 7 | Homo sapiens (human) | IC50 | 6.8654 | 6 | 15 |
| Histone deacetylase 8 | Homo sapiens (human) | IC50 | 11.0577 | 8 | 17 |
| Histone deacetylase 9 | Homo sapiens (human) | IC50 | 0.2910 | 1 | 1 |
| Hyaluronidase-1 | Homo sapiens (human) | IC50 | 2,000.0000 | 1 | 1 |
| Ileal sodium/bile acid cotransporter | Homo sapiens (human) | Ki | 28.0000 | 1 | 1 |
| Inositol hexakisphosphate kinase 2 | Homo sapiens (human) | IC50 | 0.9000 | 1 | 1 |
| Inositol polyphosphate multikinase | Homo sapiens (human) | IC50 | 7.2000 | 1 | 1 |
| Insulin receptor | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Integrase | Human immunodeficiency virus 1 | IC50 | 100.0000 | 1 | 1 |
| integrase, partial | Human immunodeficiency virus 1 | IC50 | 19.2405 | 2 | 2 |
| Integrin alpha-4 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Integrin beta-1 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Kappa-type opioid receptor | Cavia porcellus (domestic guinea pig) | IC50 | 250.0000 | 1 | 1 |
| Lactase-phlorizin hydrolase | Rattus norvegicus (Norway rat) | IC50 | 4.4000 | 1 | 1 |
| lens epithelium-derived growth factor p75 | Homo sapiens (human) | IC50 | 19.2405 | 2 | 2 |
| Leukotriene A-4 hydrolase | Homo sapiens (human) | IC50 | 10.0000 | 2 | 2 |
| Lysine-specific histone demethylase 1A | Homo sapiens (human) | IC50 | 6.2817 | 6 | 6 |
| Lysosomal acid glucosylceramidase | Homo sapiens (human) | IC50 | 75.5000 | 1 | 2 |
| Lysosomal alpha-glucosidase | Homo sapiens (human) | Ki | 0.0590 | 1 | 1 |
| Maltase-glucoamylase, intestinal | Homo sapiens (human) | IC50 | 0.1200 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | IC50 | 9.4250 | 4 | 4 |
| Mitogen-activated protein kinase 1 | Homo sapiens (human) | IC50 | 9.0000 | 1 | 1 |
| Mitogen-activated protein kinase 10 | Homo sapiens (human) | IC50 | 25.9000 | 1 | 2 |
| Mitogen-activated protein kinase 14 | Homo sapiens (human) | IC50 | 25.9000 | 1 | 2 |
| Mitogen-activated protein kinase 3 | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| MO15-related protein kinase Pfmrk | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 15.0000 | 2 | 2 |
| Multidrug resistance-associated protein 1 | Homo sapiens (human) | IC50 | 3.0000 | 1 | 1 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 72.4600 | 2 | 5 |
| Multidrug resistance-associated protein 5 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| NAD-dependent protein deacetylase sirtuin-2 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| neutrophil cytosol factor 1 | Homo sapiens (human) | IC50 | 0.3900 | 1 | 1 |
| Nuclear receptor corepressor 1 | Homo sapiens (human) | IC50 | 0.0220 | 1 | 1 |
| Nuclear receptor corepressor 2 | Homo sapiens (human) | IC50 | 0.0450 | 1 | 1 |
| nuclear receptor subfamily 0 group B member 1 | Homo sapiens (human) | IC50 | 0.8335 | 1 | 1 |
| P2Y purinoceptor 12 | Homo sapiens (human) | Ki | 36.4000 | 1 | 1 |
| Peroxisome proliferator-activated receptor alpha | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Peroxisome proliferator-activated receptor alpha | Mus musculus (house mouse) | IC50 | 1.1500 | 1 | 1 |
| Peroxisome proliferator-activated receptor gamma | Homo sapiens (human) | IC50 | 5.4081 | 8 | 8 |
| Peroxisome proliferator-activated receptor gamma | Mus musculus (house mouse) | IC50 | 0.7000 | 1 | 1 |
| Peroxisome proliferator-activated receptor gamma | Rattus norvegicus (Norway rat) | IC50 | 0.7000 | 1 | 1 |
| Peroxisome proliferator-activated receptor gamma | Homo sapiens (human) | Ki | 0.5761 | 8 | 8 |
| Poly [ADP-ribose] polymerase 1 | Homo sapiens (human) | IC50 | 0.1096 | 13 | 17 |
| Poly [ADP-ribose] polymerase 2 | Homo sapiens (human) | IC50 | 0.1687 | 3 | 5 |
| Poly [ADP-ribose] polymerase 2 | Mus musculus (house mouse) | IC50 | 0.0405 | 1 | 2 |
| Poly [ADP-ribose] polymerase tankyrase-1 | Homo sapiens (human) | IC50 | 1.1077 | 4 | 6 |
| Poly [ADP-ribose] polymerase tankyrase-2 | Homo sapiens (human) | IC50 | 1.2683 | 3 | 5 |
| Polyamine deacetylase HDAC10 | Homo sapiens (human) | IC50 | 0.2910 | 1 | 1 |
| Polyphenol oxidase 2 | Agaricus bisporus | IC50 | 350.0000 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15 | Oryctolagus cuniculus (rabbit) | IC50 | 3.9750 | 1 | 1 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | IC50 | 30.0000 | 2 | 2 |
| Prolyl endopeptidase | Homo sapiens (human) | IC50 | 12.1500 | 2 | 2 |
| Protein mono-ADP-ribosyltransferase PARP10 | Homo sapiens (human) | IC50 | 6.3123 | 2 | 4 |
| Protein mono-ADP-ribosyltransferase PARP12 | Homo sapiens (human) | IC50 | 0.2269 | 1 | 2 |
| Protein mono-ADP-ribosyltransferase PARP14 | Homo sapiens (human) | IC50 | 4.1843 | 1 | 2 |
| Protein mono-ADP-ribosyltransferase PARP15 | Homo sapiens (human) | IC50 | 8.9563 | 1 | 2 |
| Protein mono-ADP-ribosyltransferase PARP3 | Homo sapiens (human) | IC50 | 1.4377 | 1 | 2 |
| Protein mono-ADP-ribosyltransferase PARP4 | Homo sapiens (human) | IC50 | 0.7586 | 1 | 1 |
| Protein-lysine 6-oxidase | Homo sapiens (human) | IC50 | 75.5000 | 1 | 2 |
| Proto-oncogene tyrosine-protein kinase Src | Homo sapiens (human) | IC50 | 15.0000 | 1 | 1 |
| Pyruvate kinase PKM | Homo sapiens (human) | IC50 | 11.4000 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | IC50 | 5.5920 | 5 | 6 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | IC50 | 6.4100 | 1 | 1 |
| Serine/threonine-protein kinase PLK1 | Homo sapiens (human) | IC50 | 35.2633 | 3 | 3 |
| Serine/threonine-protein kinase PLK2 | Homo sapiens (human) | IC50 | 14.7200 | 1 | 1 |
| Serine/threonine-protein kinase PLK3 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| steroidogenic factor 1 | Homo sapiens (human) | IC50 | 67.5180 | 1 | 1 |
| Steryl-sulfatase | Homo sapiens (human) | IC50 | 0.8000 | 1 | 1 |
| Sucrase-isomaltase, intestinal | Rattus norvegicus (Norway rat) | IC50 | 2.2200 | 2 | 2 |
| Thioredoxin reductase 1, cytoplasmic | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |
| Transient receptor potential cation channel subfamily M member 8 | Homo sapiens (human) | IC50 | 12.0000 | 2 | 2 |
| Trehalase | Rattus norvegicus (Norway rat) | IC50 | 28.0000 | 1 | 1 |
| Trypsin-1 | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| Trypsin-2 | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| Trypsin-3 | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| Tyrosinase | Mus musculus (house mouse) | Ki | 2,800.0000 | 3 | 3 |
| Tyrosine-protein kinase Lck | Homo sapiens (human) | IC50 | 0.4700 | 1 | 1 |
| Tyrosine-protein phosphatase non-receptor type 1 | Homo sapiens (human) | IC50 | 135.0000 | 2 | 2 |
| Vascular endothelial growth factor receptor 2 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Xanthine dehydrogenase/oxidase | Bos taurus (cattle) | IC50 | 8.2000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Homo sapiens (human) | Kd | 0.0170 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | EC50 | 0.0005 | 1 | 1 |
| Adenosine receptor A2b | Homo sapiens (human) | EC50 | 0.0310 | 1 | 1 |
| Bromodomain testis-specific protein | Homo sapiens (human) | Kd | 0.1786 | 7 | 7 |
| Bromodomain-containing protein 2 | Homo sapiens (human) | Kd | 0.0827 | 12 | 12 |
| Bromodomain-containing protein 3 | Homo sapiens (human) | Kd | 0.0599 | 10 | 10 |
| Bromodomain-containing protein 4 | Homo sapiens (human) | EC50 | 0.1203 | 3 | 3 |
| Bromodomain-containing protein 4 | Homo sapiens (human) | Kd | 0.0912 | 31 | 57 |
| Chain A, Bromodomain testis-specific protein | Homo sapiens (human) | Kd | 0.1901 | 1 | 1 |
| Chain A, Bromodomain-containing protein 4 | Homo sapiens (human) | Kd | 0.0490 | 1 | 1 |
| CREB-binding protein | Homo sapiens (human) | Kd | 9.6000 | 1 | 1 |
| Free fatty acid receptor 1 | Homo sapiens (human) | EC50 | 812.8310 | 1 | 1 |
| G-protein coupled bile acid receptor 1 | Homo sapiens (human) | EC50 | 61.8833 | 3 | 3 |
| Glutamate receptor ionotropic, NMDA 1 | Rattus norvegicus (Norway rat) | Kd | 10.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2A | Rattus norvegicus (Norway rat) | Kd | 10.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2B | Rattus norvegicus (Norway rat) | Kd | 10.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2C | Rattus norvegicus (Norway rat) | Kd | 10.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2D | Rattus norvegicus (Norway rat) | Kd | 10.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3A | Rattus norvegicus (Norway rat) | Kd | 10.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3B | Rattus norvegicus (Norway rat) | Kd | 10.0000 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | EC50 | 0.3600 | 2 | 2 |
| Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | EC50 | 0.5500 | 1 | 2 |
| Muscarinic acetylcholine receptor M2 | Rattus norvegicus (Norway rat) | EC50 | 0.5500 | 1 | 2 |
| Muscarinic acetylcholine receptor M3 | Rattus norvegicus (Norway rat) | EC50 | 0.5500 | 1 | 2 |
| Muscarinic acetylcholine receptor M4 | Rattus norvegicus (Norway rat) | EC50 | 0.5500 | 1 | 2 |
| Muscarinic acetylcholine receptor M5 | Rattus norvegicus (Norway rat) | EC50 | 0.5500 | 1 | 2 |
| Peroxisome proliferator-activated receptor alpha | Homo sapiens (human) | EC50 | 6.6867 | 3 | 3 |
| Peroxisome proliferator-activated receptor gamma | Homo sapiens (human) | EC50 | 0.8027 | 36 | 36 |
| Peroxisome proliferator-activated receptor gamma | Mus musculus (house mouse) | EC50 | 0.6200 | 2 | 2 |
| Peroxisome proliferator-activated receptor gamma | Homo sapiens (human) | Kd | 0.8710 | 1 | 1 |
| Phospholipase A2 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| Poly [ADP-ribose] polymerase 1 | Homo sapiens (human) | EC50 | 0.0200 | 1 | 1 |
| Poly [ADP-ribose] polymerase 1 | Homo sapiens (human) | Kd | 0.1100 | 1 | 1 |
| POsterior Segregation | Caenorhabditis elegans | EC50 | 186.6810 | 1 | 1 |
| Protein mono-ADP-ribosyltransferase PARP3 | Homo sapiens (human) | Kd | 0.7000 | 1 | 1 |
| recombinase A | Mycobacterium tuberculosis H37Rv | EC50 | 78.6500 | 2 | 2 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | EC50 | 10.2700 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | Kd | 11.9500 | 2 | 2 |
| Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | Homo sapiens (human) | Kd | 1.2500 | 1 | 1 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | EC50 | 113.8860 | 1 | 1 |
| Transporter | Rattus norvegicus (Norway rat) | EC50 | 0.0005 | 1 | 1 |
| Zinc finger protein mex-5 | Caenorhabditis elegans | EC50 | 113.8860 | 1 | 1 |