agmatine has been researched along with Pain in 18 studies
Agmatine: Decarboxylated arginine, isolated from several plant and animal sources, e.g., pollen, ergot, herring sperm, octopus muscle.
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The present study examined the anti-hypernociceptive effects of agmatine (AGM) in acute and chronic models of behavioural pain in mice." | 7.74 | Anti-hypernociceptive properties of agmatine in persistent inflammatory and neuropathic models of pain in mice. ( Calixto, JB; Gadotti, VM; Paszcuk, AF; Quintão, NL; Rodrigues, AL; Santos, AR; Tibola, D, 2007) |
| "Effect of agmatine (10-400 mg/kg) on neuropathic pain in a rat model produced by loose ligatures around the common sciatic nerve was studied." | 7.72 | Agmatine attenuates neuropathic pain in rats: possible mediation of nitric oxide and noradrenergic activity in the brainstem and cerebellum. ( Delen, Y; Onal, A; Soykan, N; Ulker, S, 2003) |
| "Intraspinal injection of the AMPA/metabotropic receptor agonist quisqualic acid (QUIS) results in a pathophysiology that leads to excessive grooming behavior, which has been proposed as a model of spontaneous at-level pain after spinal cord injury (SCI)." | 7.72 | Effects of agmatine, interleukin-10, and cyclosporin on spontaneous pain behavior after excitotoxic spinal cord injury in rats. ( Fairbanks, CA; Wilcox, GL; Yezierski, RP; Yu, CG, 2003) |
| "Agmatine is an endogenous neuromodulator that has been previously implicated in the regulation of reward and pain processing." | 5.91 | Agmatine reduces alcohol drinking and produces antinociceptive effects in rodent models of alcohol use disorder. ( Becker, HC; Cucinello-Ragland, JA; Davis, EC; Edwards, S; Lopez, MF; Regunathan, S, 2023) |
| "Agmatine is a polycationic amine synthesized from L-arginine by arginine decarboxylase in brain and several tissues." | 5.32 | Effect of agmatine on acute and mononeuropathic pain. ( Aricioglu, F; Bozkurt, A; Korcegez, E; Ozyalcin, S, 2003) |
| "Painful reaction of rats to intraperitoneal injections of L-arginine, Nw-nitro-L-arginine, and agmatine was studied on the model of formalin-induced inflammation." | 3.74 | Effects of NO-modulating agents on the development of acute painful reaction in rats. ( Dyuizen, IV; Lamash, NE, 2008) |
| "Agmatine, an endogenous cationic amine resulting from the decarboxylation of L-arginine, produces antihyperalgesic and antiallodynic effects in animal models of chronic neuropathic and inflammatory pain." | 3.74 | Agmatine induces antihyperalgesic effects in diabetic rats and a superadditive interaction with R(-)-3-(2-carboxypiperazine-4-yl)-propyl-1-phosphonic acid, a N-methyl-D-aspartate-receptor antagonist. ( Courteix, C; Eschalier, A; Fialip, J; Hernandez, A; Pélissier, T; Privat, AM, 2007) |
| "The present study examined the anti-hypernociceptive effects of agmatine (AGM) in acute and chronic models of behavioural pain in mice." | 3.74 | Anti-hypernociceptive properties of agmatine in persistent inflammatory and neuropathic models of pain in mice. ( Calixto, JB; Gadotti, VM; Paszcuk, AF; Quintão, NL; Rodrigues, AL; Santos, AR; Tibola, D, 2007) |
| "Effect of agmatine (10-400 mg/kg) on neuropathic pain in a rat model produced by loose ligatures around the common sciatic nerve was studied." | 3.72 | Agmatine attenuates neuropathic pain in rats: possible mediation of nitric oxide and noradrenergic activity in the brainstem and cerebellum. ( Delen, Y; Onal, A; Soykan, N; Ulker, S, 2003) |
| "Intraspinal injection of the AMPA/metabotropic receptor agonist quisqualic acid (QUIS) results in a pathophysiology that leads to excessive grooming behavior, which has been proposed as a model of spontaneous at-level pain after spinal cord injury (SCI)." | 3.72 | Effects of agmatine, interleukin-10, and cyclosporin on spontaneous pain behavior after excitotoxic spinal cord injury in rats. ( Fairbanks, CA; Wilcox, GL; Yezierski, RP; Yu, CG, 2003) |
| "Agmatine is an endogenous neuromodulator that, based on animal studies, has the potential for new drug development." | 2.44 | Agmatine : metabolic pathway and spectrum of activity in brain. ( Halaris, A; Plietz, J, 2007) |
| "Agmatine is an amine that is formed by decarboxylation of L-arginine by the enzyme arginine decarboxylase (ADC) and hydrolyzed by the enzyme agmatinase to putrescine." | 2.43 | Agmatine: biological role and therapeutic potentials in morphine analgesia and dependence. ( Regunathan, S, 2006) |
| "Agmatine is an endogenous neuromodulator that has been previously implicated in the regulation of reward and pain processing." | 1.91 | Agmatine reduces alcohol drinking and produces antinociceptive effects in rodent models of alcohol use disorder. ( Becker, HC; Cucinello-Ragland, JA; Davis, EC; Edwards, S; Lopez, MF; Regunathan, S, 2023) |
| "treatment with histamine increased the phosphorylation of the NR1 subunit of N-methyl-D-aspartate (NMDA) receptors." | 1.37 | Involvement of glial cells in the nociceptive behaviors induced by a high-dose of histamine administered intrathecally. ( Iwata, Y; Katsuyama, S; Komatsu, T; Mizoguchi, H; Onodera, K; Orito, T; Sakurada, S; Sakurada, T; Watanabe, C; Watanabe, H; Yonezawa, A, 2011) |
| "Agmatine is a polycationic amine synthesized from L-arginine by arginine decarboxylase in brain and several tissues." | 1.32 | Effect of agmatine on acute and mononeuropathic pain. ( Aricioglu, F; Bozkurt, A; Korcegez, E; Ozyalcin, S, 2003) |
| "Agmatine alone did not produce any significant change on radiant tail-flick latencies, but it potentiated significantly and dose-dependently morphine-induced (1 mg/kg) analgesia." | 1.31 | Agmatine potentiates the analgesic effect of morphine by an alpha(2)-adrenoceptor-mediated mechanism in mice. ( Uzbay, IT; Yeşilyurt, O, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 15 (83.33) | 29.6817 |
| 2010's | 2 (11.11) | 24.3611 |
| 2020's | 1 (5.56) | 2.80 |
| Authors | Studies |
|---|---|
| Lopez, MF | 1 |
| Davis, EC | 1 |
| Cucinello-Ragland, JA | 1 |
| Regunathan, S | 3 |
| Edwards, S | 1 |
| Becker, HC | 1 |
| Dyuizen, IV | 1 |
| Lamash, NE | 1 |
| Mizoguchi, H | 1 |
| Komatsu, T | 1 |
| Iwata, Y | 1 |
| Watanabe, C | 1 |
| Watanabe, H | 1 |
| Orito, T | 1 |
| Katsuyama, S | 1 |
| Yonezawa, A | 1 |
| Onodera, K | 1 |
| Sakurada, T | 1 |
| Sakurada, S | 1 |
| Li, JX | 1 |
| Zhang, Y | 1 |
| Winter, JC | 1 |
| Onal, A | 1 |
| Delen, Y | 1 |
| Ulker, S | 1 |
| Soykan, N | 1 |
| Yu, CG | 2 |
| Fairbanks, CA | 3 |
| Wilcox, GL | 2 |
| Yezierski, RP | 2 |
| Aricioglu, F | 1 |
| Korcegez, E | 1 |
| Bozkurt, A | 1 |
| Ozyalcin, S | 1 |
| Ruiz-Durantez, E | 1 |
| Llorente, J | 1 |
| Ulibarri, I | 1 |
| Pineda, J | 1 |
| Ugedo, L | 1 |
| Gadotti, VM | 2 |
| Tibola, D | 2 |
| Paszcuk, AF | 2 |
| Rodrigues, AL | 2 |
| Calixto, JB | 2 |
| Santos, AR | 2 |
| Tan-No, K | 1 |
| Esashi, A | 1 |
| Nakagawasai, O | 1 |
| Niijima, F | 1 |
| Furuta, S | 1 |
| Sato, T | 1 |
| Satoh, S | 1 |
| Yasuhara, H | 1 |
| Tadano, T | 1 |
| Horvath, G | 1 |
| Kekesi, G | 1 |
| Tuboly, G | 1 |
| Benedek, G | 1 |
| Goracke-Postle, CJ | 1 |
| Overland, AC | 1 |
| Riedl, MS | 1 |
| Stone, LS | 2 |
| Courteix, C | 1 |
| Privat, AM | 1 |
| Pélissier, T | 1 |
| Hernandez, A | 1 |
| Eschalier, A | 1 |
| Fialip, J | 1 |
| Quintão, NL | 1 |
| Halaris, A | 1 |
| Plietz, J | 1 |
| Schreiber, KL | 1 |
| Brewer, KL | 1 |
| Kitto, KF | 1 |
| Nguyen, HO | 1 |
| Grocholski, BM | 1 |
| Shoeman, DW | 1 |
| Kehl, LJ | 1 |
| Reis, DJ | 1 |
| Yeşilyurt, O | 1 |
| Uzbay, IT | 1 |
2 reviews available for agmatine and Pain
| Article | Year |
|---|---|
Agmatine: biological role and therapeutic potentials in morphine analgesia and dependence.
Topics: Agmatine; Analgesia; Analgesics, Opioid; Animals; Drug Tolerance; Morphine; Morphine Dependence; Pai | 2006 |
Agmatine : metabolic pathway and spectrum of activity in brain.
Topics: Agmatine; Animals; Brain; Central Nervous System Agents; Humans; Mental Disorders; Pain; Synaptic Tr | 2007 |
16 other studies available for agmatine and Pain
| Article | Year |
|---|---|
Agmatine reduces alcohol drinking and produces antinociceptive effects in rodent models of alcohol use disorder.
Topics: Agmatine; Alcohol Drinking; Alcoholism; Analgesics; Animals; Ethanol; Female; Hyperalgesia; Male; Mi | 2023 |
Effects of NO-modulating agents on the development of acute painful reaction in rats.
Topics: Agmatine; Animals; Arginine; Behavior, Animal; Formaldehyde; Inflammation; Injections, Intraperitone | 2008 |
Involvement of glial cells in the nociceptive behaviors induced by a high-dose of histamine administered intrathecally.
Topics: Agmatine; Animals; Behavior, Animal; Blotting, Western; Dizocilpine Maleate; Dose-Response Relations | 2011 |
Morphine-induced antinociception in the rat: supra-additive interactions with imidazoline I₂ receptor ligands.
Topics: Adrenergic alpha-2 Receptor Antagonists; Agmatine; Analgesics; Analgesics, Opioid; Animals; Benzofur | 2011 |
Agmatine attenuates neuropathic pain in rats: possible mediation of nitric oxide and noradrenergic activity in the brainstem and cerebellum.
Topics: Agmatine; Analgesics; Animals; Brain Stem; Cerebellum; Chromatography, High Pressure Liquid; Dose-Re | 2003 |
Effects of agmatine, interleukin-10, and cyclosporin on spontaneous pain behavior after excitotoxic spinal cord injury in rats.
Topics: Agmatine; Animals; Cyclosporine; Disease Models, Animal; Excitatory Amino Acid Agonists; Grooming; I | 2003 |
Effect of agmatine on acute and mononeuropathic pain.
Topics: Agmatine; Analgesics; Animals; Male; Motor Activity; Pain; Pain Measurement; Rats; Rats, Wistar; Sci | 2003 |
Agmatine-morphine interaction on nociception in mice.
Topics: Agmatine; Analgesia; Analgesics, Opioid; Animals; Drug Interactions; Enzyme Inhibitors; Mice; Morphi | 2003 |
Contribution of spinal glutamatergic receptors to the antinociception caused by agmatine in mice.
Topics: Agmatine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analgesics; Animals; Cycloleucin | 2006 |
Intrathecally administered D-cycloserine produces nociceptive behavior through the activation of N-methyl-D-aspartate receptor ion-channel complex acting on the glycine recognition site.
Topics: 2-Amino-5-phosphonovalerate; Agmatine; Animals; Cycloserine; Dizocilpine Maleate; Dose-Response Rela | 2007 |
Antinociceptive interactions of triple and quadruple combinations of endogenous ligands at the spinal level.
Topics: Adenosine; Agmatine; Analgesics; Animals; Area Under Curve; Disease Models, Animal; Drug Combination | 2007 |
Potassium- and capsaicin-induced release of agmatine from spinal nerve terminals.
Topics: Afferent Pathways; Agmatine; Animals; Capsaicin; Male; Nerve Fibers, Unmyelinated; Nociceptors; Pain | 2007 |
Agmatine induces antihyperalgesic effects in diabetic rats and a superadditive interaction with R(-)-3-(2-carboxypiperazine-4-yl)-propyl-1-phosphonic acid, a N-methyl-D-aspartate-receptor antagonist.
Topics: Agmatine; Animals; Anticonvulsants; Diabetes Mellitus, Experimental; Drug Interactions; Excitatory A | 2007 |
Anti-hypernociceptive properties of agmatine in persistent inflammatory and neuropathic models of pain in mice.
Topics: Agmatine; Analgesics; Analysis of Variance; Animals; Behavior, Animal; Cytokines; Disease Models, An | 2007 |
Agmatine reverses pain induced by inflammation, neuropathy, and spinal cord injury.
Topics: Agmatine; Analgesics; Animals; Immunohistochemistry; Inflammation; Male; Mice; N-Methylaspartate; Pa | 2000 |
Agmatine potentiates the analgesic effect of morphine by an alpha(2)-adrenoceptor-mediated mechanism in mice.
Topics: Adrenergic alpha-Antagonists; Agmatine; Analgesics, Opioid; Animals; Central Nervous System; Dose-Re | 2001 |