Page last updated: 2024-10-29

iohexol and Pain

iohexol has been researched along with Pain in 31 studies

Iohexol: An effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality.
iohexol : A benzenedicarboxamide compound having N-(2,3-dihydroxypropyl)carbamoyl groups at the 1- and 3-positions, iodo substituents at the 2-, 4- and 6-positions and an N-(2,3-dihydroxypropyl)acetamido group at the 5-position.

Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.

Research Excerpts

ExcerptRelevanceReference
"Two low-osmolality contrast agents, ioxaglate meglumine/sodium and iohexol were compared with diatrizoate meglumine/sodium in a controlled double blind study of 126 patients undergoing arteriography for peripheral vascular disease to determine which caused the least pain."5.06Pain in peripheral arteriography: an assessment of conventional versus ionic and non-ionic low-osmolality contrast agents. ( Campbell, DR; Fraser, DB; Murphy, G, 1988)
"Comparing iohexol 240 mg I/ml, iohexol 300 mg I/ml and meglumine-Ca metrizoate 200 mg I/ml in phlebography of the leg in patients on or without anticoagulants, no sign of post-phlebographic thrombosis was found using the 125I-fibrinogen uptake test and repeat phlebography."5.05Iohexol in phlebography of the leg. A comparative investigation with meglumine metrizoate. ( Andrew, E; Enge, I; Gjølberg, T, 1983)
"Two non-ionic contrast media, iohexol and metrizamide, were compared in a double-blind clinical trial which included 50 patients who underwent lumbar myelography for disc herniation or spinal stenosis."5.05Lumbar myelography with iohexol and metrizamide. A double-blind clinical trial. ( Ekholm, SE; Hindmarsh, T; Kido, DK; Sahler, L; Sands, M, 1984)
"), elicit a pain response comparable to that caused by bradykinin (BK) or capsaicin (CAP)."3.68Mechanism of pain induced by radiocontrast media. ( Antunes, E; Ballejo, G; Corrado, AP; de Nucci, G, 1992)
"Lumbar myelography with iohexol (Omnipaque) was performed in 103 consecutive adult patients with low back pain or sciatica."3.67Lumbar myelography with Omnipaque (iohexol). ( Bach-Gansmo, T; Lilleås, F; Weber, H, 1986)
"Heat and pain were scored on visual analog scales."2.68Iohexol vs. ioxaglate in lower extremity angiography: a comparative randomized double-blind study in 80 patients. ( Guit, GL; Krouwels, MM; Overbosch, EH, 1996)
" Safety was assessed by monitoring vital signs (blood pressure, pulse and respiration), clinical laboratory studies and observation of adverse effects prior to and after injection of contrast medium."2.67A double blind clinical study comparing the safety, tolerance and efficacy of ioversol 240 and iohexol 240 (Omnipaque 240) in ascending venography. ( Spinks, BC; Wilkins, RA, 1990)
"Iohexol was well tolerated in renal and visceral angiography."2.65Iohexol in lower extremity, renal and visceral angiography. Survey and present state. ( Kolbenstvedt, A, 1983)
"The incidence of post-myelogram headache was similar to that reported for inpatients."1.28Outpatient myelography: an acceptable and cost-effective technique. ( Barber, CJ; Choudhri, AH; Johnson, J; Rowlands, PC; Stevens, JM, 1989)

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-199015 (48.39)18.7374
1990's14 (45.16)18.2507
2000's1 (3.23)29.6817
2010's1 (3.23)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kok, M1
Mihl, C1
Hendriks, BM1
Altintas, S1
Eijsvoogel, NG1
Kietselaer, BL1
Wildberger, JE1
Das, M1
D'Onofrio, M1
Caffarri, S1
Zamboni, G1
Falconi, M1
Mansueto, G1
Valk, J1
Crezée, F1
Olislagers-de Slegte, RG1
Kolbenstvedt, A1
Cronqvist, S1
Wolf, GL1
Lea Thomas, M1
Briggs, GM1
Keeling, FP1
Gjølberg, T1
Andrew, E1
Enge, I1
Sackett, JF1
Bergsjordet, B1
Seeger, JF1
Kieffer, SA1
Hindmarsh, T1
Ekholm, SE1
Kido, DK2
Sahler, L1
Sands, M1
Morris, TW1
Ekholm, S1
Plassche, W1
Erickson, JL1
Nyman, U1
Nilsson, P1
Westergren, A1
Krause, W1
Press, WR1
Frenzel, T1
Harding, JR1
Bertazzoli, M1
Spinazzi, A1
Shinomiya, K1
Nakao, K1
Shindoh, S1
Mochida, K1
Furuya, K1
Krouwels, MM1
Overbosch, EH1
Guit, GL1
Cohan, RH1
Bullard, MA1
Ellis, JH1
Jan, SC1
Francis, IR1
Garner, WL1
Dunnick, NR1
Corrado, AP1
Ballejo, G1
Antunes, E1
de Nucci, G1
Rieser, R1
Beinborn, W1
Ney, N1
Wang, H1
Kumar, AJ1
Zinreich, SJ1
Higgins, YM1
Long, DM1
Bryan, RN1
Tallroth, K1
Soini, J1
Antti-Poika, I1
Konttinen, YT1
Honkanen, V1
Yrjönen, T1
Lindequist, S1
Justesen, P1
Larsen, C1
Rasmussen, F1
Ida, M1
Kurabayashi, T1
Ohbayashi, N1
Honda, E1
Sasaki, T1
Berde, CB1
Sethna, NF1
Fisher, DE1
Kahn, CH1
Chandler, P1
Grier, HE1
Wilkins, RA1
Spinks, BC1
Billström, A1
Hietala, SO1
Sunnegårdh, O1
Sjödin, JG1
Wirell, S1
Choudhri, AH1
Rowlands, PC1
Barber, CJ1
Johnson, J1
Stevens, JM1
Murphy, G1
Campbell, DR1
Fraser, DB1
Sovak, M1
Halkovich, CA1
Foster, SJ1
Tajima, N1
Lilleås, F1
Bach-Gansmo, T1
Weber, H1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Can Contrast Infused Sonography Using Air Bubbles Replace Hysterosalpingogram as the Diagnostic Evaluation of Fallopian Tube Patency Following Hysteroscopic Sterilization Using Essure[NCT02628873]21 participants (Actual)Interventional2015-12-31Terminated (stopped due to Essure no longer sold in the US after Dec 2018; Sponsor requested trial be ended)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Physician Evaluation of Uterine Cavity

"Observed image of uterus (normal or not normal). Assessor commented on uterine cavity to determine whether cavity was normal versus abnormal, e.g., bicornuate uterus or any notable uterine deformity. Data were coded as normal' or not normal." (NCT02628873)
Timeframe: At time of HyCoSy procedure

InterventionParticipants (Count of Participants)
Arm 1 (HyCoSy Followed by HSG)13
Arm 2 (HSG Followed by HyCoSy)6

Fallopian Tube Patency - HyCoSy vs HSG

Observed flow of fluid/bubbles through fallopian tubes. (NCT02628873)
Timeframe: At time of procedure

,
Interventionfallopian tubes observed to be closed (Count of Units)
Number of tubes closed per first procedureNumber of tubes closed per second procedure
Arm 1 (HyCoSy Followed by HSG)2425
Arm 2 (HSG Followed by HyCoSy)1212

Pain Scores

Patient reported pain scale score on visual pain scale (rated 0 for no pain to 10 for severe pain with corresponding faces) (NCT02628873)
Timeframe: At time of procedures

,
Interventionunits on a scale (Mean)
HSG post procedure pain scoreHyCoSy post procedure pain score
Arm 1 (HyCoSy Followed by HSG)1.42.4
Arm 2 (HSG Followed by HyCoSy)1.82.3

Trials

18 trials available for iohexol and Pain

ArticleYear
Patient Comfort During Contrast Media Injection in Coronary Computed Tomographic Angiography Using Varying Contrast Media Concentrations and Flow Rates: Results From the EICAR Trial.
    Investigative radiology, 2016, Volume: 51, Issue:12

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Computed Tomography Angiography; Contrast Media; Coronar

2016
Comparison of iohexol 300 mg I/ml and Hexabrix 320 mg I/ml in central angiography. A double-blind trial.
    Neuroradiology, 1984, Volume: 26, Issue:3

    Topics: Adult; Blood Pressure; Cerebral Angiography; Clinical Trials as Topic; Contrast Media; Double-Blind

1984
Iohexol in lower extremity, renal and visceral angiography. Survey and present state.
    Acta radiologica. Supplementum, 1983, Volume: 366

    Topics: Angiography; Blood Pressure; Clinical Trials as Topic; Contrast Media; Heart Rate; Humans; Iodobenzo

1983
Iohexol in cerebral angiography. Survey and present state.
    Acta radiologica. Supplementum, 1983, Volume: 366

    Topics: Blood Pressure; Central Nervous System Diseases; Cerebral Angiography; Clinical Trials as Topic; Con

1983
Adult peripheral angiography. Results from four North American randomized clinical trials of ionic media versus iohexol.
    Acta radiologica. Supplementum, 1983, Volume: 366

    Topics: Angiography; Blood Pressure; Clinical Trials as Topic; Contrast Media; Diatrizoate; Diatrizoate Megl

1983
Iohexol and meglumine iothalamate in phlebography of the leg. Comparison of the tolerance.
    Acta radiologica. Supplementum, 1983, Volume: 366

    Topics: Adult; Aged; Clinical Trials as Topic; Contrast Media; Double-Blind Method; Drug Tolerance; Edema; F

1983
Iohexol in phlebography of the leg. A comparative investigation with meglumine metrizoate.
    Acta radiologica. Supplementum, 1983, Volume: 366

    Topics: Adult; Aged; Anticoagulants; Clinical Trials as Topic; Contrast Media; Drug Tolerance; Female; Human

1983
Digital subtraction angiography. Comparison of meglumine-Na diatrizoate with iohexol.
    Acta radiologica. Supplementum, 1983, Volume: 366

    Topics: Adult; Aged; Angiography; Carotid Arteries; Clinical Trials as Topic; Contrast Media; Diatrizoate; D

1983
Lumbar myelography with iohexol and metrizamide. A double-blind clinical trial.
    Acta radiologica: diagnosis, 1984, Volume: 25, Issue:5

    Topics: Adolescent; Adult; Aged; Contrast Media; Double-Blind Method; Drug Evaluation; Female; Headache; Hum

1984
Pain and hemodynamic effects in aortofemoral angiography. Clinical comparison of iohexol, ioxaglate and metrizamide.
    Acta radiologica: diagnosis, 1982, Volume: 23, Issue:4

    Topics: Aged; Aortography; Blood Pressure; Contrast Media; Female; Femoral Artery; Heart Rate; Hemodynamics;

1982
A randomized, double-blind, parallel group trial of iomeprol, iohexol and iopamidol in intravenous urography.
    The British journal of radiology, 1995, Volume: 68, Issue:811

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Contrast Media; Double-Blind Method; Female; Humans; Inj

1995
Iohexol vs. ioxaglate in lower extremity angiography: a comparative randomized double-blind study in 80 patients.
    European journal of radiology, 1996, Volume: 22, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Angiography; Contrast Media; Double-Blind Method; Female; Humans; Io

1996
A double-blind comparative study on the contrast quality, tolerance and safety of ioversol 300 versus iohexol 300 in central venous angiography (C.V. DSA).
    Annales de radiologie, 1992, Volume: 35, Issue:4 Pt 2

    Topics: Adult; Aged; Aged, 80 and over; Angiography; Contrast Media; Double-Blind Method; Female; Humans; Hy

1992
Diagnostic quality and complications of hysterosalpingography: oil- versus water-soluble contrast media--a randomized prospective study.
    Radiology, 1991, Volume: 179, Issue:1

    Topics: Contrast Media; Diatrizoate Meglumine; Ethiodized Oil; Extravasation of Diagnostic and Therapeutic M

1991
Radiographic quality and patient discomfort in sialography: comparison of iohexol with iothalamate.
    Dento maxillo facial radiology, 1991, Volume: 20, Issue:2

    Topics: Adult; Chi-Square Distribution; Contrast Media; Double-Blind Method; Female; Humans; Iohexol; Iothal

1991
A double blind clinical study comparing the safety, tolerance and efficacy of ioversol 240 and iohexol 240 (Omnipaque 240) in ascending venography.
    Clinical radiology, 1990, Volume: 41, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Contrast Media; Double-Blind Method; Female; Hot Temperature; Humans

1990
Contrast media and pain in patients with acute ureteral stone obstruction. A comparative study with iohexol and metrizoate.
    Acta radiologica (Stockholm, Sweden : 1987), 1990, Volume: 31, Issue:5

    Topics: Adult; Aged; Female; Humans; Iohexol; Male; Metrizoic Acid; Middle Aged; Pain; Radiography; Ureteral

1990
Pain in peripheral arteriography: an assessment of conventional versus ionic and non-ionic low-osmolality contrast agents.
    Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes, 1988, Volume: 39, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Angiography; Clinical Trials as Topic; Contrast Media; Diatrizoate M

1988

Other Studies

13 other studies available for iohexol and Pain

ArticleYear
Contrast-enhanced ultrasonography in the characterization of pancreatic mucinous cystadenoma.
    Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine, 2004, Volume: 23, Issue:8

    Topics: Adult; Contrast Media; Cystadenoma, Mucinous; Diagnosis, Differential; Female; Humans; Iohexol; Micr

2004
Comparison of iohexol and meglumine-Na diatrizoate in cerebral angiography.
    Acta radiologica. Supplementum, 1983, Volume: 366

    Topics: Blood Pressure; Cerebral Angiography; Contrast Media; Diatrizoate; Diatrizoate Meglumine; Double-Bli

1983
Preclinical testing of iopromide. 1st communication: pharmacological evaluation.
    Arzneimittel-Forschung, 1994, Volume: 44, Issue:10

    Topics: Animals; Bleeding Time; Complement Activation; Contrast Media; Dogs; Erythrocytes; Hemolysis; Histam

1994
Evaluation of cervical diskography in pain origin and provocation.
    Journal of spinal disorders, 1993, Volume: 6, Issue:5

    Topics: Adult; Aged; Atrophy; Cervical Vertebrae; Contrast Media; Epidural Space; Female; Humans; Interverte

1993
Local reactions after injection of iodinated contrast material: detection, management, and outcome.
    Academic radiology, 1997, Volume: 4, Issue:11

    Topics: Blister; Catheterization; Contrast Media; Diatrizoate; Diatrizoate Meglumine; Equipment Design; Extr

1997
Mechanism of pain induced by radiocontrast media.
    Toxicology letters, 1992, Volume: 64-65 Spec No

    Topics: Animals; Bradykinin; Contrast Media; Dogs; Female; Iohexol; Iothalamic Acid; Male; Pain; Ruthenium R

1992
Iohexol cervical myelography in adult outpatients.
    Spine, 1991, Volume: 16, Issue:12

    Topics: Ambulatory Care; Cervical Vertebrae; Evaluation Studies as Topic; Female; Headache; Humans; Incidenc

1991
Premedication and short term complications in iohexol discography.
    Annales chirurgiae et gynaecologiae, 1991, Volume: 80, Issue:1

    Topics: Adult; Back Pain; Diazepam; Female; Glycopyrrolate; Headache; Humans; Injections, Spinal; Interverte

1991
Celiac plexus blockade for a 3-year-old boy with hepatoblastoma and refractory pain.
    Pediatrics, 1990, Volume: 86, Issue:5

    Topics: Bupivacaine; Carcinoma, Hepatocellular; Celiac Plexus; Child, Preschool; Ethanol; Humans; Iohexol; L

1990
Outpatient myelography: an acceptable and cost-effective technique.
    The British journal of radiology, 1989, Volume: 62, Issue:735

    Topics: Adult; Aged; Back Pain; Female; Headache; Humans; Iohexol; Male; Middle Aged; Myelography; Nausea; O

1989
Current contrast media and ioxilan. Comparative evaluation of vascular pain by aversion conditioning.
    Investigative radiology, 1988, Volume: 23 Suppl 1

    Topics: Animals; Conditioning, Psychological; Contrast Media; Female; Iohexol; Iopamidol; Osmolar Concentrat

1988
[Experimental and clinical studies of non-ionic isoosmolality contrast medium (iohexol 140)--II. IADSA in clinical practice].
    Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica, 1986, Apr-25, Volume: 46, Issue:4

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Angiography; Child; Contrast Media; Drug Evaluation; Hem

1986
Lumbar myelography with Omnipaque (iohexol).
    Neuroradiology, 1986, Volume: 28, Issue:4

    Topics: Electroencephalography; Headache; Humans; Iohexol; Lumbar Vertebrae; Myelography; Pain

1986