8-hydroxy-2-(di-n-propylamino)tetralin has been researched along with Pain in 40 studies
8-Hydroxy-2-(di-n-propylamino)tetralin: A serotonin 1A-receptor agonist that is used experimentally to test the effects of serotonin.
8-OH-DPAT : A tetralin substituted at positions 1 and 7 by hydroxy and dipropylamino groups respectively
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The present study was undertaken to evaluate the potential role of 5-HT(1A) receptors and opioids receptors in the analgesic effect of tramadol in neuropathic pain." | 7.74 | Role of serotonin 5-HT1A and opioid receptors in the antiallodynic effect of tramadol in the chronic constriction injury model of neuropathic pain in rats. ( Berrocoso, E; De Benito, MD; Mico, JA, 2007) |
| "The present study was undertaken to evaluate the potential role of 5-HT(1A) receptors and opioids receptors in the analgesic effect of tramadol in neuropathic pain." | 3.74 | Role of serotonin 5-HT1A and opioid receptors in the antiallodynic effect of tramadol in the chronic constriction injury model of neuropathic pain in rats. ( Berrocoso, E; De Benito, MD; Mico, JA, 2007) |
| "We hypothesized that hyperalgesia of 6-OHDA rats may be related to increased excitability of SDH neurons, and functional change of 5-HT3 receptor may reverse the hyperalgesia of 6-OHDA lesioned rats and decrease cell excitability of SDH neurons." | 1.72 | Inhibition of Spinal 5-HT3 Receptor and Spinal Dorsal Horn Neuronal Excitability Alleviates Hyperalgesia in a Rat Model of Parkinson's Disease. ( An, MQ; Dai, YP; Dong, LG; Gu, HY; Li, CJ; Liu, CF; Liu, LB; Mao, CJ; Wang, F; Zhang, LG, 2022) |
| "Ventilatory depression is a serious side-effect of opioid analgesics." | 1.39 | Effects of cholinesterase inhibitors and serotonin-1A receptor agonists on morphine-induced ventilatory depression and antinociception in rats. ( Haji, A; Kimura, S; Ohi, Y, 2013) |
| "(B) Fentanyl was administered in situ to investigate the interaction with 8-OH-DPAT on phrenic nerve activity and nociceptive CFR." | 1.35 | The counteraction of opioid-induced ventilatory depression by the serotonin 1A-agonist 8-OH-DPAT does not antagonize antinociception in rats in situ and in vivo. ( Dutschmann, M; Guenther, U; Hoeft, A; Manzke, T; Putensen, C; Wrigge, H; Zinserling, J, 2009) |
| " pretreatment (25 min) with morphine sulfate, 8-OH-DPAT, buspirone and 5-CT shifted the morphine sulfate dose-response curve 3- to 5-fold to the right." | 1.29 | Differential roles of 5-hydroxytryptamine1A and 5-hydroxytryptamine1B receptor subtypes in modulating spinal nociceptive transmission in mice. ( Alhaider, AA; Wilcox, GL, 1993) |
| "Procaine was shown to elicit theta at a mean latency of 52 s and for a mean duration of 21." | 1.29 | Pharmacological suppression of the median raphe nucleus with serotonin1A agonists, 8-OH-DPAT and buspirone, produces hippocampal theta rhythm in the rat. ( Fortin, WJ; Kinney, GG; Kocsis, B; Vertes, RP, 1994) |
| "We conclude that serotonin produces hyperalgesia by a direct action on the primary afferent neuron via the 5-HT1A subset of serotonin receptors." | 1.28 | Serotonin is a directly-acting hyperalgesic agent in the rat. ( Levine, JD; Taiwo, YO, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (12.50) | 18.7374 |
| 1990's | 21 (52.50) | 18.2507 |
| 2000's | 10 (25.00) | 29.6817 |
| 2010's | 3 (7.50) | 24.3611 |
| 2020's | 1 (2.50) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, H | 1 |
| Altenbach, RJ | 1 |
| Carr, TL | 1 |
| Chandran, P | 1 |
| Hsieh, GC | 1 |
| Lewis, LG | 1 |
| Manelli, AM | 1 |
| Milicic, I | 1 |
| Marsh, KC | 1 |
| Miller, TR | 1 |
| Strakhova, MI | 1 |
| Vortherms, TA | 1 |
| Wakefield, BD | 1 |
| Wetter, JM | 1 |
| Witte, DG | 1 |
| Honore, P | 1 |
| Esbenshade, TA | 1 |
| Brioni, JD | 1 |
| Cowart, MD | 1 |
| Valhondo, M | 1 |
| Marco, I | 1 |
| Martín-Fontecha, M | 1 |
| Vázquez-Villa, H | 1 |
| Ramos, JA | 1 |
| Berkels, R | 1 |
| Lauterbach, T | 1 |
| Benhamú, B | 1 |
| López-Rodríguez, ML | 1 |
| Li, CJ | 1 |
| Zhang, LG | 1 |
| Liu, LB | 1 |
| An, MQ | 1 |
| Dong, LG | 1 |
| Gu, HY | 1 |
| Dai, YP | 1 |
| Wang, F | 1 |
| Mao, CJ | 1 |
| Liu, CF | 1 |
| Kimura, S | 1 |
| Ohi, Y | 1 |
| Haji, A | 1 |
| Wei, H | 1 |
| Ma, A | 1 |
| Wang, YX | 1 |
| Pertovaara, A | 1 |
| Guenther, U | 1 |
| Manzke, T | 1 |
| Wrigge, H | 1 |
| Dutschmann, M | 1 |
| Zinserling, J | 1 |
| Putensen, C | 1 |
| Hoeft, A | 1 |
| Charkhpour, M | 1 |
| Nayebi, AR | 1 |
| Doustar, Y | 1 |
| Hassanzadeh, K | 1 |
| Bardin, L | 2 |
| Colpaert, FC | 2 |
| Harte, SE | 1 |
| Kender, RG | 1 |
| Borszcz, GS | 1 |
| Berrocoso, E | 1 |
| De Benito, MD | 1 |
| Mico, JA | 1 |
| Alhaider, AA | 1 |
| Wilcox, GL | 1 |
| Ali, Z | 1 |
| Wu, G | 2 |
| Kozlov, A | 1 |
| Barasi, S | 1 |
| Vertes, RP | 1 |
| Kinney, GG | 1 |
| Kocsis, B | 1 |
| Fortin, WJ | 1 |
| Korneyev, AY | 1 |
| Seredenin, SB | 1 |
| Lucas, JJ | 1 |
| Mellström, B | 1 |
| Colado, MI | 1 |
| Naranjo, JR | 1 |
| Abbott, FV | 1 |
| Hong, Y | 1 |
| Blier, P | 1 |
| Sanchez, A | 1 |
| Niedbala, B | 1 |
| Feria, M | 1 |
| Laporte, AM | 1 |
| Doyen, C | 1 |
| Nevo, IT | 1 |
| Chauveau, J | 1 |
| Hauw, JJ | 1 |
| Hamon, M | 1 |
| Gjerstad, J | 1 |
| Tjolsen, A | 1 |
| Hole, K | 7 |
| Roychowdhury, SM | 1 |
| Heinricher, MM | 1 |
| Galeotti, N | 1 |
| Ghelardini, C | 1 |
| Bartolini, A | 1 |
| Ormazábal, MJ | 1 |
| Goicoechea, C | 1 |
| Alfaro, MJ | 1 |
| Sánchez, E | 1 |
| Martín, MI | 1 |
| Shannon, HE | 1 |
| Lutz, EA | 1 |
| Zhang, Y | 1 |
| Yang, Z | 1 |
| Gao, X | 1 |
| Tarayre, JP | 1 |
| Koek, W | 1 |
| Sasaki, M | 1 |
| Ishizaki, K | 1 |
| Obata, H | 1 |
| Goto, F | 1 |
| Taiwo, YO | 2 |
| Heller, PH | 1 |
| Levine, JD | 2 |
| Mjellem, N | 1 |
| Lund, A | 1 |
| Eide, PK | 6 |
| Størkson, R | 1 |
| Tjølsen, A | 1 |
| Bell, J | 1 |
| Zhang, XN | 1 |
| Whitaker-Azmitia, PM | 1 |
| Carli, M | 1 |
| Tranchina, S | 1 |
| Samanin, R | 1 |
| Kavaliers, M | 1 |
| Colwell, DD | 1 |
| Joly, NM | 1 |
| Fasmer, OB | 2 |
| Berge, OG | 3 |
| Post, C | 1 |
| Broch, OJ | 1 |
| el-Yassir, N | 1 |
| Fleetwood-Walker, SM | 1 |
| Mitchell, R | 1 |
| Ogren, SO | 1 |
40 other studies available for 8-hydroxy-2-(di-n-propylamino)tetralin and Pain
| Article | Year |
|---|---|
cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzofurans; Carrageenan; Disease Models, Animal; | 2008 |
New serotonin 5-HT1A receptor agonists endowed with antinociceptive activity in vivo.
Topics: Analgesics; Animals; Binding, Competitive; Cyclic AMP; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP | 2013 |
Inhibition of Spinal 5-HT3 Receptor and Spinal Dorsal Horn Neuronal Excitability Alleviates Hyperalgesia in a Rat Model of Parkinson's Disease.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Dopamine; Hyperalgesia; Ondansetron; Oxidopamine; P | 2022 |
Effects of cholinesterase inhibitors and serotonin-1A receptor agonists on morphine-induced ventilatory depression and antinociception in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analgesia; Animals; Buspirone; Cholinesterase Inhibitors; Do | 2013 |
Role of spinal 5-HT receptors in cutaneous hypersensitivity induced by REM sleep deprivation.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Injections, Spinal; Male; Microinjections; Pain; Pa | 2008 |
The counteraction of opioid-induced ventilatory depression by the serotonin 1A-agonist 8-OH-DPAT does not antagonize antinociception in rats in situ and in vivo.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analgesics, Opioid; Animals; Dose-Response Relationship, Dru | 2009 |
8-OH-DPAT prevents morphine-induced apoptosis in rat dorsal raphe nucleus: a possible mechanism for attenuating morphine tolerance.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analgesics, Opioid; Animals; Apoptosis; Disease Models, Anim | 2010 |
Role of spinal 5-HT(1A) receptors in morphine analgesia and tolerance in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Afferent Pathways; Analgesics, Opioid; Animals; Dose-Respons | 2004 |
Activation of 5-HT1A and 5-HT7 receptors in the parafascicular nucleus suppresses the affective reaction of rats to noxious stimulation.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Affect; Analysis of Variance; Animals; Behavior, Animal; Dop | 2005 |
Role of serotonin 5-HT1A and opioid receptors in the antiallodynic effect of tramadol in the chronic constriction injury model of neuropathic pain in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analgesics, Opioid; Animals; Chronic Disease; Disease Models | 2007 |
Differential roles of 5-hydroxytryptamine1A and 5-hydroxytryptamine1B receptor subtypes in modulating spinal nociceptive transmission in mice.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Buspirone; Male; Mice; Morphine; | 1993 |
The actions of 5-HT1 agonists and antagonists on nociceptive processing in the rat spinal cord: results from behavioural and electrophysiological studies.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Injections, Spinal; Male; Neurons; Pain; Piperazine | 1994 |
Pharmacological suppression of the median raphe nucleus with serotonin1A agonists, 8-OH-DPAT and buspirone, produces hippocampal theta rhythm in the rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Buspirone; Electroencephalography; Hippocampus; Mal | 1994 |
Effect of 5-HT-1A receptor agonists on paw licking reaction on hot plate and unpunished drinking in rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Buspirone; Drinking Behavior; Indoles; Male; Pain; | 1993 |
Molecular mechanisms of pain: serotonin1A receptor agonists trigger transactivation by c-fos of the prodynorphin gene in spinal cord neurons.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Afferent Pathways; Animals; Base Sequence; Cells, Cultured; | 1993 |
Activation of 5-HT2A receptors potentiates pain produced by inflammatory mediators.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Dinoprostone; Dose-Response Relat | 1996 |
Modulation of neuropathic pain in rats by intrathecally injected serotonergic agonists.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Injections, Spinal; Male; Pain; Piperazines; Rats; | 1995 |
Autoradiographic mapping of serotonin 5-HT1A, 5-HT1D, 5-HT2A and 5-HT3 receptors in the aged human spinal cord.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aged; Aged, 80 and over; Aging; Autoradiography; Humans; Ket | 1996 |
The effect of 5-HT1A receptor stimulation on nociceptive dorsal horn neurones in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Female; Nerve Fibers; Neurons; Pain; Piperazines; P | 1996 |
Effects of iontophoretically applied serotonin on three classes of physiologically characterized putative pain modulating neurons in the rostral ventromedial medulla of lightly anesthetized rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Anesthesia, General; Animals; Evoked Potentials; Iontophores | 1997 |
5-HT1A agonists induce central cholinergic antinociception.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Buspirone; GTP-Binding Proteins; Male; Mice; Motor | 1997 |
Study of mechanisms of calcitonin analgesia in mice. Involvement of 5-HT3 receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analgesics; Animals; Brain Chemistry; Calcitonin; Dose-Respo | 1999 |
Yohimbine produces antinociception in the formalin test in rats: involvement of serotonin(1A) receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Antagonists; Animals; Benzofurans; Bridged | 2000 |
The role of 5-hydroxytryptamine1A and 5-hydroxytryptamine1B receptors in modulating spinal nociceptive transmission in normal and carrageenan-injected rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Carrageenan; Electric Stimulation; Electrophysiolog | 2001 |
In the formalin model of tonic nociceptive pain, 8-OH-DPAT produces 5-HT1A receptor-mediated, behaviorally specific analgesia.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analgesia; Animals; Behavior, Animal; Dose-Response Relation | 2001 |
Effects of 5-HT2 and 5-HT3 receptors on the modulation of nociceptive transmission in rat spinal cord according to the formalin test.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Dose-Response Relationship, Drug; For | 2001 |
Mediation of serotonin hyperalgesia by the cAMP second messenger system.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; 8-Hydroxy- | 1992 |
The role of 5-HT1A and 5-HT1B receptors in spinal nociceptive transmission and in the modulation of NMDA induced behaviour.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Dose-Response Relationship, Drug; | 1992 |
Stimulation of 5-HT1 receptors in the spinal cord changes substance P-induced behaviour.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Analgesia; Animals; Indoles; Injections, Spina | 1992 |
Serotonin is a directly-acting hyperalgesic agent in the rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Dose-Response Relationship, Drug; Hydroxyurea; Hype | 1992 |
5-HT3 receptor-active drugs alter development of spinal serotonergic innervation: lack of effect of other serotonergic agents.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Biguanides; Female; Fenfluramine; Hypoglycem | 1992 |
8-Hydroxy-2-(di-n-propylamino)tetralin, a 5-HT1A receptor agonist, impairs performance in a passive avoidance task.
Topics: 5,7-Dihydroxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Avoidance Learning; Electr | 1992 |
Interactions between serotonin and substance P in the spinal regulation of nociception.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analgesics; Animals; Indoles; Injections, Spinal; Male; Mete | 1991 |
Sex differences in opioid and non-opioid mediated predator-induced analgesia in mice.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analgesia; Animals; Cats; Female; Guinea Pigs; Male; Mice; N | 1991 |
The role of spinal cord 5-HT1A and 5-HT1B receptors in the modulation of a spinal nociceptive reflex.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Indoles; Injections, Spinal; Male; Methoxydimethylt | 1990 |
Subsensitivity of serotonin and substance P receptors involved in nociception after repeated administration of a serotonin receptor agonist.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analgesics; Animals; Male; Methoxydimethyltryptamines; Mice; | 1989 |
Effects of the putative 5-HT1A receptor agonist 8-OH-2-(di-n-propylamino)tetralin on nociceptive sensitivity in mice.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Dose-Response Relationship, Drug; Injections, Intra | 1986 |
5-HT depletion with 5,7-DHT, PCA and PCPA in mice: differential effects on the sensitivity to 5-MeODMT, 8-OH-DPAT and 5-HTP as measured by two nociceptive tests.
Topics: 5-Hydroxytryptophan; 5,7-Dihydroxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; | 1988 |
Heterogeneous effects of serotonin in the dorsal horn of rat: the involvement of 5-HT1 receptor subtypes.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Action Potentials; Animals; Indoles; Ketanserin; Male; Neuro | 1988 |
The putative serotonin receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin antagonizes the antinociceptive effect of morphine.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Central Nervous System; Male; Mice; Morphine; Napht | 1985 |